ADAMTS18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may regulate hemostatic balance and function as a tumor suppressor. Mutations in this gene may be associated with microcornea, myopic chorioretinal atrophy, and telecanthus (MMCAT) and cone-rod dystrophy in human patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lens development in camera-type eye (GO:0002088)8.07911811
2lens fiber cell development (GO:0070307)6.73706729
3epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)5.12807277
4lymphangiogenesis (GO:0001946)4.23820738
5cerebellar granule cell differentiation (GO:0021707)4.21832702
6lens fiber cell differentiation (GO:0070306)4.16526370
7sulfation (GO:0051923)4.08118817
8positive regulation of cardiac muscle cell differentiation (GO:2000727)3.90331882
9retina vasculature morphogenesis in camera-type eye (GO:0061299)3.77411622
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.76555444
11cardiac epithelial to mesenchymal transition (GO:0060317)3.76279396
12gamma-aminobutyric acid transport (GO:0015812)3.68083896
13spinal cord development (GO:0021510)3.64458248
14positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.62121182
15positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.61328101
16positive regulation of odontogenesis (GO:0042482)3.53499312
17positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.51057317
18mesenchymal cell development (GO:0014031)3.49968571
19negative regulation of axon guidance (GO:1902668)3.46587217
20artery smooth muscle contraction (GO:0014824)3.39869824
21central nervous system projection neuron axonogenesis (GO:0021952)3.39158194
22neuron projection extension involved in neuron projection guidance (GO:1902284)3.35209938
23axon extension involved in axon guidance (GO:0048846)3.35209938
24response to pheromone (GO:0019236)3.34793888
25embryonic retina morphogenesis in camera-type eye (GO:0060059)3.34218683
26negative chemotaxis (GO:0050919)3.33840261
27artery development (GO:0060840)3.31995547
28layer formation in cerebral cortex (GO:0021819)3.29036118
29positive regulation of heart rate (GO:0010460)3.27745011
30positive regulation of catenin import into nucleus (GO:0035413)3.26492064
31neuron remodeling (GO:0016322)3.23168744
32regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.22640497
33ganglion development (GO:0061548)3.22532891
34regulation of endothelial cell differentiation (GO:0045601)3.21916040
35lens morphogenesis in camera-type eye (GO:0002089)3.20480081
36planar cell polarity pathway involved in neural tube closure (GO:0090179)3.19846703
37glomerular filtration (GO:0003094)3.18783229
38regulation of vasculogenesis (GO:2001212)3.14856221
39regulation of non-canonical Wnt signaling pathway (GO:2000050)3.13858013
40branching involved in labyrinthine layer morphogenesis (GO:0060670)3.13742706
41presynaptic membrane assembly (GO:0097105)3.13338810
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.12163119
43lateral sprouting from an epithelium (GO:0060601)3.10818502
44neuronal stem cell maintenance (GO:0097150)3.08583706
45axonal fasciculation (GO:0007413)3.04864549
46potassium ion import (GO:0010107)3.04202898
47positive regulation of vesicle fusion (GO:0031340)3.00529795
48blood vessel maturation (GO:0001955)2.99833211
49tonic smooth muscle contraction (GO:0014820)2.97897061
50negative regulation of keratinocyte proliferation (GO:0010839)2.97706265
51negative regulation of cartilage development (GO:0061037)2.97136991
52lymph vessel development (GO:0001945)2.94726344
53negative regulation of smooth muscle cell differentiation (GO:0051151)2.93961337
54regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.92360898
55positive regulation of digestive system process (GO:0060456)2.89967505
56purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.89471157
573-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.89471157
58negative regulation of hormone biosynthetic process (GO:0032353)2.87136438
59negative regulation of hormone metabolic process (GO:0032351)2.87136438
60cyclic nucleotide catabolic process (GO:0009214)2.84432209
61cAMP catabolic process (GO:0006198)2.83495637
62dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.83483177
63endothelial cell differentiation (GO:0045446)2.83234696
64cell differentiation in hindbrain (GO:0021533)2.82997243
65negative regulation of systemic arterial blood pressure (GO:0003085)2.82621690
66peripheral nervous system neuron development (GO:0048935)2.82462079
67proximal/distal pattern formation (GO:0009954)2.81708649
68collecting duct development (GO:0072044)2.81075546
69cerebral cortex radially oriented cell migration (GO:0021799)2.80085886
70glomerulus development (GO:0032835)2.79929805
71pharyngeal system development (GO:0060037)2.78614188
72negative regulation of cytosolic calcium ion concentration (GO:0051481)2.78196194
73stem cell development (GO:0048864)2.77925314
74transmission of nerve impulse (GO:0019226)2.77200967
75dendritic spine morphogenesis (GO:0060997)2.76482349
76body morphogenesis (GO:0010171)2.75241948
77regulation of cardioblast proliferation (GO:0003264)2.74171696
78regulation of secondary heart field cardioblast proliferation (GO:0003266)2.74171696
79innervation (GO:0060384)2.73712302
80cell differentiation involved in metanephros development (GO:0072202)2.73378071
81synaptic vesicle endocytosis (GO:0048488)2.73146755
82camera-type eye development (GO:0043010)2.70626928
83presynaptic membrane organization (GO:0097090)2.69591553
84kidney mesenchyme development (GO:0072074)2.69435863
85negative regulation of multicellular organism growth (GO:0040015)2.68762912
86non-canonical Wnt signaling pathway (GO:0035567)2.68469061
87wound healing, spreading of epidermal cells (GO:0035313)2.68347938
88negative regulation of Rho protein signal transduction (GO:0035024)2.67840034
89negative regulation of synaptic transmission, GABAergic (GO:0032229)2.67524111
90Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.67214867
91renal filtration (GO:0097205)2.66538634
92anterior/posterior axis specification, embryo (GO:0008595)2.64956708
93patterning of blood vessels (GO:0001569)2.64740285
94cardiac right ventricle morphogenesis (GO:0003215)2.63899057
95hindlimb morphogenesis (GO:0035137)2.63841631
96lung-associated mesenchyme development (GO:0060484)2.63677209
97cerebellar Purkinje cell differentiation (GO:0021702)2.63150928
98cardiac muscle hypertrophy in response to stress (GO:0014898)2.62720582
99muscle hypertrophy in response to stress (GO:0003299)2.62720582
100cardiac muscle adaptation (GO:0014887)2.62720582
101regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.62385646
102endothelium development (GO:0003158)2.62188759
103positive regulation of synaptic transmission, GABAergic (GO:0032230)2.61550047
104negative regulation of axon extension involved in axon guidance (GO:0048843)2.60830193
105nephron tubule formation (GO:0072079)2.58646097
106regulation of axon guidance (GO:1902667)2.58089221
107positive regulation of cGMP biosynthetic process (GO:0030828)2.57044160
108renal tubule morphogenesis (GO:0061333)2.56951521
109generation of neurons (GO:0048699)2.56887358
110endothelial cell proliferation (GO:0001935)2.56650452
111neuron recognition (GO:0008038)2.55410728
112regulation of glomerulus development (GO:0090192)2.55195066
113limb development (GO:0060173)2.55148695
114appendage development (GO:0048736)2.55148695
115positive regulation of fatty acid oxidation (GO:0046321)2.54766429
116neuron fate specification (GO:0048665)2.54223885
117neural crest cell development (GO:0014032)2.54061628
118regulation of timing of cell differentiation (GO:0048505)2.53978212
119atrioventricular valve morphogenesis (GO:0003181)2.53474045
120synaptic transmission, glutamatergic (GO:0035249)2.53197770
121regulation of development, heterochronic (GO:0040034)2.53071505
122ovulation from ovarian follicle (GO:0001542)2.52813934
123central nervous system neuron axonogenesis (GO:0021955)2.52797501
124regulation of establishment of planar polarity (GO:0090175)2.52772718
125response to BMP (GO:0071772)2.52585269
126cellular response to BMP stimulus (GO:0071773)2.52585269
127Notch signaling involved in heart development (GO:0061314)2.51745909
128cardiac ventricle morphogenesis (GO:0003208)2.51186187
129clathrin coat assembly (GO:0048268)2.51123758
130dorsal/ventral axis specification (GO:0009950)2.51037346
131respiratory tube development (GO:0030323)2.51024038
132endocardial cushion morphogenesis (GO:0003203)2.50923398
133somite development (GO:0061053)2.50759181
134cell migration involved in heart development (GO:0060973)2.50636406
135regulation of cell proliferation involved in kidney development (GO:1901722)2.50503959
136regulation of phospholipid biosynthetic process (GO:0071071)2.50231821
137hindbrain development (GO:0030902)2.50028306
138positive regulation of synapse maturation (GO:0090129)2.49932417
139cell migration in hindbrain (GO:0021535)2.49094859
140cGMP biosynthetic process (GO:0006182)2.48876052
141mesenchymal cell differentiation (GO:0048762)2.47830320
142regulation of short-term neuronal synaptic plasticity (GO:0048172)2.47727483
143organ formation (GO:0048645)2.47544355
144locomotory exploration behavior (GO:0035641)2.46827107
145retinal cone cell development (GO:0046549)2.46634512
146membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.46541040
147positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.46195516
148gamma-aminobutyric acid signaling pathway (GO:0007214)2.45976345
149dentate gyrus development (GO:0021542)2.45732211
150aorta morphogenesis (GO:0035909)2.45632843
151regulation of cardiac muscle cell contraction (GO:0086004)2.45073474
152cell surface receptor signaling pathway involved in heart development (GO:0061311)2.44846074
153nephron tubule morphogenesis (GO:0072078)2.44703877
154nephron epithelium morphogenesis (GO:0072088)2.44703877
155positive regulation of cAMP-mediated signaling (GO:0043950)2.43937200
156head development (GO:0060322)2.43846410
157vocalization behavior (GO:0071625)2.43237855
158glial cell proliferation (GO:0014009)2.42584530
159cerebellum development (GO:0021549)2.42462766
160protein localization to synapse (GO:0035418)2.42338744
161dendritic spine organization (GO:0097061)2.42216334
162insulin-like growth factor receptor signaling pathway (GO:0048009)2.42191267
163outflow tract septum morphogenesis (GO:0003148)2.42110510
164regulation of cardiac muscle cell differentiation (GO:2000725)2.41658922
165limb bud formation (GO:0060174)2.40773883
166lung morphogenesis (GO:0060425)2.40103775
167positive regulation of endothelial cell differentiation (GO:0045603)2.39906896
168apical protein localization (GO:0045176)2.39799847
169lung lobe morphogenesis (GO:0060463)2.39721579
170cochlea development (GO:0090102)2.37898181
171morphogenesis of an epithelial sheet (GO:0002011)2.37378214
172positive regulation of synapse assembly (GO:0051965)2.36678346
173regulation of axon extension involved in axon guidance (GO:0048841)2.35971594
174heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.35510455
175glutamate secretion (GO:0014047)2.34277494
176negative regulation of JUN kinase activity (GO:0043508)2.33856838
177glucocorticoid receptor signaling pathway (GO:0042921)2.33113675
178* eye development (GO:0001654)2.31243808
179growth hormone secretion (GO:0030252)2.31174243
180neurotransmitter secretion (GO:0007269)2.30925952
181dendrite morphogenesis (GO:0048813)2.30329754
182suckling behavior (GO:0001967)2.29673873
183establishment of nucleus localization (GO:0040023)2.29476685
184mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.29235968
185mesenchyme morphogenesis (GO:0072132)2.29029186
186pituitary gland development (GO:0021983)2.28698220
187mesenchymal cell differentiation involved in renal system development (GO:2001012)2.28571987
188mesenchymal cell differentiation involved in kidney development (GO:0072161)2.28571987
189membrane repolarization during action potential (GO:0086011)2.27404932
190positive regulation of gastrulation (GO:2000543)2.27117771
191postsynaptic membrane organization (GO:0001941)2.26082818

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.95113007
2EZH2_22144423_ChIP-Seq_EOC_Human3.69363773
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.85217009
4EZH2_27304074_Chip-Seq_ESCs_Mouse2.73276902
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.73019843
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.67143448
7* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.62208909
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.60864765
9* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60854603
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60277954
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60277954
12* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.58759283
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54087526
14GBX2_23144817_ChIP-Seq_PC3_Human2.51182820
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32418810
16RNF2_27304074_Chip-Seq_ESCs_Mouse2.29832284
17TAF15_26573619_Chip-Seq_HEK293_Human2.19213613
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.16543566
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.11311510
20PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.10609505
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.10021127
22CBX2_27304074_Chip-Seq_ESCs_Mouse2.07334766
23* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05342383
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95279107
25RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.89954493
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89942461
27* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.88861579
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.87646987
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.84300842
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83933898
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.83066133
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.80510770
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79667641
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79318171
35DROSHA_22980978_ChIP-Seq_HELA_Human1.75899337
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73221680
37VDR_22108803_ChIP-Seq_LS180_Human1.72280334
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69007396
39ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.64455807
40EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.60141070
41RING1B_27294783_Chip-Seq_NPCs_Mouse1.58964361
42* EWS_26573619_Chip-Seq_HEK293_Human1.50340199
43RNF2_27304074_Chip-Seq_NSC_Mouse1.49969922
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.49852534
45RING1B_27294783_Chip-Seq_ESCs_Mouse1.49600369
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47250302
47AHR_22903824_ChIP-Seq_MCF-7_Human1.44348115
48GATA2_21666600_ChIP-Seq_HMVEC_Human1.44091525
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43338433
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41843158
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.41067033
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40357134
53* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39218209
54TRIM28_21343339_ChIP-Seq_HEK293_Human1.38056453
55SMAD4_21799915_ChIP-Seq_A2780_Human1.37822075
56AR_21572438_ChIP-Seq_LNCaP_Human1.36887228
57FUS_26573619_Chip-Seq_HEK293_Human1.36821685
58* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.36203264
59REST_21632747_ChIP-Seq_MESCs_Mouse1.36088869
60* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34212186
61* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34114521
62ISL1_27105846_Chip-Seq_CPCs_Mouse1.33221209
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32347341
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.31929125
65* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.30955870
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30715230
67P300_19829295_ChIP-Seq_ESCs_Human1.27009955
68KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.26954964
69NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26927568
70TP53_16413492_ChIP-PET_HCT116_Human1.24868303
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23921617
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23791873
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.23761868
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23408658
75TP53_20018659_ChIP-ChIP_R1E_Mouse1.23159678
76* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.21884665
77DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20400180
78ER_23166858_ChIP-Seq_MCF-7_Human1.19404080
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18775129
80HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18553369
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17742503
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16716689
83* AR_19668381_ChIP-Seq_PC3_Human1.16613304
84ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16139657
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.15404723
86TBX3_20139965_ChIP-Seq_MESCs_Mouse1.15098067
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14659903
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14659903
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14615133
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13620744
91ZNF274_21170338_ChIP-Seq_K562_Hela1.13520748
92TBX3_20139965_ChIP-Seq_ESCs_Mouse1.13431697
93* STAT3_23295773_ChIP-Seq_U87_Human1.13239629
94* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12159833
95RUNX2_22187159_ChIP-Seq_PCA_Human1.12094586
96CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11839334
97* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10622523
98REST_18959480_ChIP-ChIP_MESCs_Mouse1.10516627
99AR_25329375_ChIP-Seq_VCAP_Human1.10249134
100KDM2B_26808549_Chip-Seq_REH_Human1.10245327
101* TCF4_23295773_ChIP-Seq_U87_Human1.10097707
102OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09757279
103TP53_18474530_ChIP-ChIP_U2OS_Human1.09643764
104SMAD3_21741376_ChIP-Seq_HESCs_Human1.08769950
105SMAD4_21741376_ChIP-Seq_EPCs_Human1.08303939
106EP300_21415370_ChIP-Seq_HL-1_Mouse1.07626429
107ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07442984
108CJUN_26792858_Chip-Seq_BT549_Human1.06471220
109NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05353335
110IGF1R_20145208_ChIP-Seq_DFB_Human1.04643902
111* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04528254
112ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04026992
113KDM2B_26808549_Chip-Seq_K562_Human1.03991513
114TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03134987
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02814559
116P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02790480
117SMAD3_21741376_ChIP-Seq_ESCs_Human1.02322176
118BCAT_22108803_ChIP-Seq_LS180_Human1.02210516
119MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01733500
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01567683
121STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01458835
122ESR1_20079471_ChIP-ChIP_T-47D_Human1.00683221
123TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98412907
124* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98225116
125PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98160534
126* SMAD4_21741376_ChIP-Seq_HESCs_Human0.97947378

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002697_abnormal_eye_size3.77845166
2MP0003283_abnormal_digestive_organ3.49640312
3MP0003787_abnormal_imprinting2.86009937
4MP0002138_abnormal_hepatobiliary_system2.79119465
5MP0005167_abnormal_blood-brain_barrier2.74952423
6MP0003941_abnormal_skin_development2.61207980
7MP0001485_abnormal_pinna_reflex2.53480500
8MP0003122_maternal_imprinting2.48475079
9MP0006292_abnormal_olfactory_placode2.48040856
10MP0000566_synostosis2.41335682
11MP0010368_abnormal_lymphatic_system2.39237092
12MP0004859_abnormal_synaptic_plasticity2.26844697
13MP0010030_abnormal_orbit_morphology2.20277366
14MP0002009_preneoplasia2.15268340
15MP0003385_abnormal_body_wall2.15099896
16MP0000778_abnormal_nervous_system2.06038384
17MP0005193_abnormal_anterior_eye2.05545730
18MP0005171_absent_coat_pigmentation2.04939998
19MP0009384_cardiac_valve_regurgitation2.01471585
20MP0002938_white_spotting2.01102472
21MP0000537_abnormal_urethra_morphology1.99612167
22MP0010234_abnormal_vibrissa_follicle1.97587122
23MP0003123_paternal_imprinting1.97254451
24MP0003121_genomic_imprinting1.95679042
25MP0004272_abnormal_basement_membrane1.91236590
26MP0003279_aneurysm1.91162003
27MP0003119_abnormal_digestive_system1.89775334
28MP0008789_abnormal_olfactory_epithelium1.87146979
29MP0009053_abnormal_anal_canal1.84741146
30MP0005367_renal/urinary_system_phenotyp1.84666467
31MP0000516_abnormal_urinary_system1.84666467
32MP0005670_abnormal_white_adipose1.81377805
33MP0000013_abnormal_adipose_tissue1.81048138
34MP0009697_abnormal_copulation1.80090154
35MP0000049_abnormal_middle_ear1.72660443
36MP0005253_abnormal_eye_physiology1.72117493
37MP0002234_abnormal_pharynx_morphology1.71987380
38MP0001177_atelectasis1.66611535
39MP0005248_abnormal_Harderian_gland1.66304502
40MP0005187_abnormal_penis_morphology1.65993401
41MP0001286_abnormal_eye_development1.65704968
42MP0002184_abnormal_innervation1.65042059
43MP0005499_abnormal_olfactory_system1.63880028
44MP0005394_taste/olfaction_phenotype1.63880028
45MP0002233_abnormal_nose_morphology1.59340167
46MP0002295_abnormal_pulmonary_circulatio1.57118219
47MP0003635_abnormal_synaptic_transmissio1.56483893
48MP0001879_abnormal_lymphatic_vessel1.50407632
49MP0001486_abnormal_startle_reflex1.48346563
50MP0000631_abnormal_neuroendocrine_gland1.47910511
51MP0000678_abnormal_parathyroid_gland1.45616659
52MP0005595_abnormal_vascular_smooth1.45355393
53MP0002092_abnormal_eye_morphology1.44850779
54MP0004130_abnormal_muscle_cell1.42847019
55MP0001188_hyperpigmentation1.42224579
56MP0005379_endocrine/exocrine_gland_phen1.39895046
57MP0005623_abnormal_meninges_morphology1.34130843
58MP0009780_abnormal_chondrocyte_physiolo1.34112213
59MP0002177_abnormal_outer_ear1.33026156
60MP0005391_vision/eye_phenotype1.32354389
61MP0003136_yellow_coat_color1.32314472
62MP0001346_abnormal_lacrimal_gland1.32097631
63MP0003880_abnormal_central_pattern1.31961721
64MP0003942_abnormal_urinary_system1.31959292
65MP0002928_abnormal_bile_duct1.31769450
66MP0004270_analgesia1.29406020
67MP0000767_abnormal_smooth_muscle1.28255324
68MP0005645_abnormal_hypothalamus_physiol1.26526330
69MP0002160_abnormal_reproductive_system1.26487019
70MP0005503_abnormal_tendon_morphology1.25722221
71MP0004145_abnormal_muscle_electrophysio1.25571813
72MP0003755_abnormal_palate_morphology1.24674078
73MP0006138_congestive_heart_failure1.24035057
74MP0001502_abnormal_circadian_rhythm1.23350978
75MP0005551_abnormal_eye_electrophysiolog1.21045999
76MP0004085_abnormal_heartbeat1.21035941
77MP0002272_abnormal_nervous_system1.20886910
78MP0000955_abnormal_spinal_cord1.19160514
79MP0005646_abnormal_pituitary_gland1.18235509
80MP0003115_abnormal_respiratory_system1.18190457
81MP0004133_heterotaxia1.17703591
82MP0002557_abnormal_social/conspecific_i1.17440959
83MP0002127_abnormal_cardiovascular_syste1.16701269
84MP0005084_abnormal_gallbladder_morpholo1.16037839
85MP0006054_spinal_hemorrhage1.15608288
86MP0002063_abnormal_learning/memory/cond1.15251464
87MP0002933_joint_inflammation1.15181142
88MP0004885_abnormal_endolymph1.14738877
89MP0003705_abnormal_hypodermis_morpholog1.14555887
90MP0002734_abnormal_mechanical_nocicepti1.14242239
91MP0004215_abnormal_myocardial_fiber1.13924500
92MP0003935_abnormal_craniofacial_develop1.13550097
93MP0000534_abnormal_ureter_morphology1.13288812
94MP0009250_abnormal_appendicular_skeleto1.11502572
95MP0000026_abnormal_inner_ear1.09813956
96MP0002249_abnormal_larynx_morphology1.09463307
97MP0001299_abnormal_eye_distance/1.09267140
98MP0009379_abnormal_foot_pigmentation1.08716475
99MP0004858_abnormal_nervous_system1.07926829
100MP0003943_abnormal_hepatobiliary_system1.07076227
101MP0003861_abnormal_nervous_system1.06288026
102MP0006072_abnormal_retinal_apoptosis1.05986956
103MP0003828_pulmonary_edema1.05837988
104MP0002932_abnormal_joint_morphology1.05649004
105MP0002735_abnormal_chemical_nociception1.04449179
106MP0002116_abnormal_craniofacial_bone1.03649757
107MP0005195_abnormal_posterior_eye1.02929797
108MP0001963_abnormal_hearing_physiology1.01063784
109MP0003938_abnormal_ear_development0.99968434
110MP0002064_seizures0.98000901
111MP0001340_abnormal_eyelid_morphology0.96753997
112MP0003937_abnormal_limbs/digits/tail_de0.95854001
113MP0000003_abnormal_adipose_tissue0.95225647
114MP0009046_muscle_twitch0.95167965
115MP0008995_early_reproductive_senescence0.95164318
116MP0005197_abnormal_uvea_morphology0.94768958
117MP0006276_abnormal_autonomic_nervous0.93158324
118MP0002572_abnormal_emotion/affect_behav0.92469662
119MP0008872_abnormal_physiological_respon0.91717339
120MP0000372_irregular_coat_pigmentation0.91375899
121MP0002733_abnormal_thermal_nociception0.91105843
122MP0003950_abnormal_plasma_membrane0.90791981
123MP0002108_abnormal_muscle_morphology0.90489923
124MP0010678_abnormal_skin_adnexa0.90028827
125MP0001614_abnormal_blood_vessel0.88871128
126MP0004742_abnormal_vestibular_system0.88640902
127MP0002638_abnormal_pupillary_reflex0.88320935
128MP0008569_lethality_at_weaning0.88012237
129MP0002152_abnormal_brain_morphology0.87885660
130MP0005423_abnormal_somatic_nervous0.87729805
131MP0000613_abnormal_salivary_gland0.87312888
132MP0001293_anophthalmia0.84724820
133MP0002925_abnormal_cardiovascular_devel0.84584239
134MP0002067_abnormal_sensory_capabilities0.84085549
135MP0000428_abnormal_craniofacial_morphol0.83836752
136MP0000462_abnormal_digestive_system0.82844590
137MP0003890_abnormal_embryonic-extraembry0.82833138
138MP0002128_abnormal_blood_circulation0.82137367
139MP0002139_abnormal_hepatobiliary_system0.81565011
140MP0002098_abnormal_vibrissa_morphology0.81150543
141MP0002882_abnormal_neuron_morphology0.80343954
142MP0002109_abnormal_limb_morphology0.79924803
143MP0001968_abnormal_touch/_nociception0.79342676
144MP0009745_abnormal_behavioral_response0.79102954
145MP0003638_abnormal_response/metabolism_0.78488560
146MP0000579_abnormal_nail_morphology0.78138030
147MP0000762_abnormal_tongue_morphology0.77201552
148MP0000230_abnormal_systemic_arterial0.76535023
149MP0000163_abnormal_cartilage_morphology0.76433558
150MP0003252_abnormal_bile_duct0.75808949
151MP0005508_abnormal_skeleton_morphology0.73577767
152MP0001905_abnormal_dopamine_level0.73269932
153MP0002752_abnormal_somatic_nervous0.72847483
154MP0005620_abnormal_muscle_contractility0.72643492

Predicted human phenotypes

RankGene SetZ-score
1Short hallux (HP:0010109)4.99996164
2Aplasia/Hypoplasia of the hallux (HP:0008362)4.63874320
3Amblyopia (HP:0000646)3.58333104
4Corneal dystrophy (HP:0001131)3.57159864
5Stenosis of the external auditory canal (HP:0000402)3.55453320
6Hemiplegia (HP:0002301)3.44801497
7Arterial tortuosity (HP:0005116)3.39389321
8Anterior segment dysgenesis (HP:0007700)3.36935817
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.33713896
10Short 4th metacarpal (HP:0010044)3.33713896
11Preaxial foot polydactyly (HP:0001841)3.30456401
12Congenital cataract (HP:0000519)3.19425085
13Hepatoblastoma (HP:0002884)3.17452117
14Short phalanx of the thumb (HP:0009660)3.09894777
15Ectopic kidney (HP:0000086)3.08766130
16Absent eyebrow (HP:0002223)2.97379780
17Fused cervical vertebrae (HP:0002949)2.95127172
18Keratoconus (HP:0000563)2.92252029
19Increased corneal curvature (HP:0100692)2.92252029
20Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.87007405
21Vascular tortuosity (HP:0004948)2.83961867
22Shallow orbits (HP:0000586)2.82521726
23Pendular nystagmus (HP:0012043)2.82047425
24Congenital, generalized hypertrichosis (HP:0004540)2.81695225
25Progressive cerebellar ataxia (HP:0002073)2.81059732
26Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.70078788
27Short 1st metacarpal (HP:0010034)2.70078788
28Genetic anticipation (HP:0003743)2.64167801
29Abnormality of the phalanges of the 2nd finger (HP:0009541)2.58789389
30Gaze-evoked nystagmus (HP:0000640)2.57055964
31Vitreoretinal degeneration (HP:0000655)2.54041826
32Papillary thyroid carcinoma (HP:0002895)2.49172092
33Congenital sensorineural hearing impairment (HP:0008527)2.45088752
34Chorioretinal atrophy (HP:0000533)2.44853421
35Neoplasm of the oral cavity (HP:0100649)2.44574175
36Vertebral fusion (HP:0002948)2.44144414
37Renal hypoplasia (HP:0000089)2.42583318
38Disproportionate short-trunk short stature (HP:0003521)2.38444879
39Abnormality of the renal collecting system (HP:0004742)2.38440177
40Abnormality of the 1st metacarpal (HP:0010009)2.36654611
41Absent eyelashes (HP:0000561)2.33536962
42Cutaneous finger syndactyly (HP:0010554)2.29663412
43Renal duplication (HP:0000075)2.29649468
44Hematochezia (HP:0002573)2.29039335
45Abnormality of the 4th metacarpal (HP:0010012)2.28412990
46Midline defect of the nose (HP:0004122)2.26639618
47Hypoplastic ischia (HP:0003175)2.24787180
48* Microcornea (HP:0000482)2.23643776
49Absent toe (HP:0010760)2.22903974
50Reticulocytopenia (HP:0001896)2.22118395
51Pancreatic cysts (HP:0001737)2.21672088
52Abnormality of the ischium (HP:0003174)2.20418178
53Duplicated collecting system (HP:0000081)2.16991032
54Bilateral microphthalmos (HP:0007633)2.16164970
55Spontaneous hematomas (HP:0007420)2.12609899
56Hypoplastic nipples (HP:0002557)2.10653580
57Scotoma (HP:0000575)2.10229364
58Down-sloping shoulders (HP:0200021)2.10209349
59Dysdiadochokinesis (HP:0002075)2.09419707
60High anterior hairline (HP:0009890)2.06942891
61Pancreatic islet-cell hyperplasia (HP:0004510)2.06432688
62Anophthalmia (HP:0000528)2.04640915
63Atrophic scars (HP:0001075)2.04216147
64Abnormality of the fovea (HP:0000493)2.04180454
65Abnormality of the vitreous humor (HP:0004327)2.03980213
66Sclerocornea (HP:0000647)2.03257163
67Chromosomal breakage induced by crosslinking agents (HP:0003221)2.02972476
68Aplasia/Hypoplasia of the fovea (HP:0008060)2.02656412
69Hypoplasia of the fovea (HP:0007750)2.02656412
70Prominent supraorbital ridges (HP:0000336)2.02459398
71Short humerus (HP:0005792)2.01820710
72Abnormality of the labia majora (HP:0012881)2.01718707
73Abnormality of the anterior chamber (HP:0000593)2.00549932
74Nuclear cataract (HP:0100018)12.5772135
75Zonular cataract (HP:0010920)11.4735770
76Pancreatic fibrosis (HP:0100732)1.99646735
77Shawl scrotum (HP:0000049)1.99537785
78Congenital stationary night blindness (HP:0007642)1.99056909
79Cutaneous syndactyly (HP:0012725)1.96525185
80* Polar cataract (HP:0010696)1.96020757
81Synostosis involving the elbow (HP:0003938)1.91890570
82Humeroradial synostosis (HP:0003041)1.91890570
83Pigmentary retinal degeneration (HP:0001146)1.91311664
84Focal motor seizures (HP:0011153)1.91226391
85Severe Myopia (HP:0011003)1.90800592
86Bifid tongue (HP:0010297)1.89862894
87Tubular atrophy (HP:0000092)1.89838749
88Diplopia (HP:0000651)1.88929823
89Abnormality of binocular vision (HP:0011514)1.88929823
90Abnormality of the hepatic vasculature (HP:0006707)1.88768156
91Synostosis of carpal bones (HP:0005048)1.86523211
92Diastasis recti (HP:0001540)1.86238133
93Action tremor (HP:0002345)1.86092021
94Confusion (HP:0001289)1.85669363
95Morphological abnormality of the middle ear (HP:0008609)1.85630286
96Myelomeningocele (HP:0002475)1.85566415
97Wide intermamillary distance (HP:0006610)1.85179850
98Aplasia/Hypoplasia of the lens (HP:0008063)1.84646326
99Trigonocephaly (HP:0000243)1.84386055
100Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82702703
101Omphalocele (HP:0001539)1.81135530
102Agitation (HP:0000713)1.80538946
103Porencephaly (HP:0002132)1.80080746
104Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79831228
105Broad hallux (HP:0010055)1.79597508
106Anteriorly placed anus (HP:0001545)1.78249931
107Mesomelia (HP:0003027)1.78207389
108Benign neoplasm of the central nervous system (HP:0100835)1.77956477
109Cerebral hemorrhage (HP:0001342)1.77045774
110Large for gestational age (HP:0001520)1.76714027
111Abolished electroretinogram (ERG) (HP:0000550)1.76603480
112True hermaphroditism (HP:0010459)1.75899389
113Anal stenosis (HP:0002025)1.73881279
114Absent thumb (HP:0009777)1.73782473
115Portal hypertension (HP:0001409)1.73662150
116Long nose (HP:0003189)1.72989992
117Iris coloboma (HP:0000612)1.71960677
118Symphalangism affecting the phalanges of the hand (HP:0009773)1.71657579
119Skull defect (HP:0001362)1.70529928
120Neoplasm of the heart (HP:0100544)1.70430416
121Aplasia/hypoplasia of the humerus (HP:0006507)1.70014621
122Bone cyst (HP:0012062)1.69299148
123Focal seizures (HP:0007359)1.69278779
124Abnormality of the middle phalanges of the toes (HP:0010183)1.69096820
125Abnormality of chromosome segregation (HP:0002916)1.68977628
126Choanal stenosis (HP:0000452)1.68483051
127Proximal tubulopathy (HP:0000114)1.67981958
128Abnormal drinking behavior (HP:0030082)1.67491162
129Polydipsia (HP:0001959)1.67491162
130Overgrowth (HP:0001548)1.66377267
131Embryonal renal neoplasm (HP:0011794)1.66152150
132Abnormality of the distal phalanx of the thumb (HP:0009617)1.65798479
133Genital tract atresia (HP:0001827)1.65273238
134Abnormality of the parietal bone (HP:0002696)1.64588779
135Vaginal atresia (HP:0000148)1.64394025
136Febrile seizures (HP:0002373)1.64339156
137Abnormality of the pubic bones (HP:0003172)1.63714092
138Hypoplastic labia majora (HP:0000059)1.63289737
139Nephroblastoma (Wilms tumor) (HP:0002667)1.63273582
140Broad metatarsal (HP:0001783)1.63174545
141Abnormality of the nasolacrimal system (HP:0000614)1.62813701
142Aplasia/Hypoplasia of the sternum (HP:0006714)1.62687104
143Osteomalacia (HP:0002749)1.60042775
144Visual hallucinations (HP:0002367)1.59169063
145Abnormality of the lacrimal duct (HP:0011481)1.58599924
146Abnormality of the aortic arch (HP:0012303)1.58309877
147Milia (HP:0001056)1.57624174
148Long clavicles (HP:0000890)1.56827913
149Ectopic anus (HP:0004397)1.55824139
150Microglossia (HP:0000171)1.55043035
151Scanning speech (HP:0002168)1.54349250
152Occipital encephalocele (HP:0002085)1.53530059
153Split foot (HP:0001839)1.53108784
154Exotropia (HP:0000577)1.52622077
155Thyroid carcinoma (HP:0002890)1.51952428
156Aplasia/Hypoplasia of the macula (HP:0008059)1.51811337
157Bell-shaped thorax (HP:0001591)1.51275469
158Rib fusion (HP:0000902)1.51103389
159Abnormal pancreas size (HP:0012094)1.50671379
160Abnormality of the diencephalon (HP:0010662)1.49208376
161Congenital primary aphakia (HP:0007707)1.48969444
162Renovascular hypertension (HP:0100817)1.48714788
163Dental malocclusion (HP:0000689)1.48096499
164Bronchomalacia (HP:0002780)1.47788567
165Absent hair (HP:0002298)1.47313390
166Hemiparesis (HP:0001269)1.46717912
167Onycholysis (HP:0001806)1.45779419
168Abnormality of the labia minora (HP:0012880)1.45069110
169Abnormality of the nasal septum (HP:0000419)1.44844540
170Labial hypoplasia (HP:0000066)1.44774064
171Coronal craniosynostosis (HP:0004440)1.42862526
172Lower limb amyotrophy (HP:0007210)1.42397206
173Long toe (HP:0010511)1.41809841
174Intestinal atresia (HP:0011100)1.40825397
175Aplasia involving bones of the upper limbs (HP:0009823)1.40545004
176Aplasia of the phalanges of the hand (HP:0009802)1.40545004
177Aplasia involving bones of the extremities (HP:0009825)1.40545004
178Abnormality of the metopic suture (HP:0005556)1.40117721
179Menstrual irregularities (HP:0000858)1.39808652
180Scrotal hypoplasia (HP:0000046)1.39603598
181Septo-optic dysplasia (HP:0100842)1.39571830
182Obstructive sleep apnea (HP:0002870)1.38637238
183Hyperglycemia (HP:0003074)1.38146155

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.15612414
2EPHB23.80826232
3STK393.65756151
4NTRK33.65110365
5AKT33.26484460
6TNIK3.16755561
7ERBB33.09394977
8WNK32.85337864
9OXSR12.73656839
10GRK12.66717287
11MAPK152.38996127
12MARK12.10453245
13SGK22.02802291
14PRPF4B1.97123133
15ADRBK21.92967343
16TGFBR21.89751109
17PTK2B1.86737986
18PIK3CG1.81630705
19SGK2231.64050846
20SGK4941.64050846
21MAPK131.61937251
22INSRR1.60475322
23LATS21.51302553
24MAP2K71.48506349
25PNCK1.46054932
26SGK31.45450448
27PLK41.44317421
28PIK3CA1.43310234
29VRK11.40863805
30LATS11.40801350
31MAP3K141.36548046
32PINK11.35426930
33TAF11.34353523
34SGK11.32780391
35PLK31.27479900
36MKNK11.24525416
37PLK21.22321352
38BCR1.21908366
39UHMK11.20224066
40WNK11.19881206
41PRKD31.18688835
42BMPR1B1.15030880
43VRK21.14515998
44ZAK1.11800236
45NTRK21.10628369
46MAP3K91.09380392
47PTK61.09297991
48FGFR21.06383387
49NUAK11.02264823
50MKNK21.00249350
51CAMKK20.99604721
52EPHA40.98269785
53SIK30.98105597
54MINK10.97146478
55DYRK1A0.96345428
56RIPK10.96253066
57MET0.95583107
58NLK0.95441717
59YES10.95184721
60STK240.93144970
61MAP2K10.91460754
62FER0.90619152
63MAP3K40.88560498
64CSNK1A1L0.87392764
65MAP3K100.87046245
66EPHA20.86859075
67KSR10.85323222
68MAPKAPK50.84876533
69DYRK30.84613763
70BMPR20.82968969
71MAP2K60.82580774
72DAPK20.82157965
73PTK20.80948946
74ACVR1B0.79497099
75CDK30.78307711
76NEK60.76738862
77PHKG20.75870472
78PHKG10.75870472
79HIPK20.75810270
80ERBB20.74493819
81EIF2AK20.73169214
82PRKCG0.72795808
83GRK50.72352112
84CASK0.71484749
85FES0.68147210
86PDGFRB0.67940912
87TGFBR10.67226999
88PRKCH0.67138412
89CDK90.66412458
90PRKG10.63034842
91ADRBK10.61052454
92TYRO30.60894977
93CAMKK10.58908676
94MST40.58530858
95CHUK0.58120007
96STK38L0.56928199
97SRPK10.56226772
98PASK0.54975199
99BRSK20.54404185
100PRKG20.54356130
101CLK10.53918172
102CSNK1G30.53321031
103STK110.52683290
104MAP2K40.52159244
105FLT30.52124219
106FGFR10.51508975
107TSSK60.51091918
108TIE10.50556116
109BRSK10.50491085
110PRKCE0.50095768
111STK380.49578382
112CSNK1G10.48739365
113CDC42BPA0.48283040
114MAPK90.48051344
115MAPK70.46347008
116SIK10.46143855
117MAP3K120.45788789
118DDR20.45511557
119WNK40.44859622
120KIT0.44512405
121PKN10.44032491
122GSK3A0.43509602
123CAMK40.42917108
124ROCK20.42498987
125MAPK80.41745562
126PRKCZ0.41698579
127PAK20.41517820
128DAPK30.40849974
129RPS6KA20.40824685
130CAMK10.40432813
131PAK60.40333601
132CSNK1G20.40324136
133CDK50.39514617
134PRKCB0.39422189
135DYRK20.39410303
136MAPK100.39239522
137PDGFRA0.38892645
138PAK40.37972216
139TLK10.37876092
140GSK3B0.37875033
141RPS6KA30.37717814
142PAK30.36201991
143CDC70.36129798
144CSNK1A10.35900814
145NTRK10.35096282
146NEK20.34698171
147ROCK10.33443061
148WEE10.33362547
149CSNK1D0.32826666
150CAMK2A0.31827488
151PRKD10.29947478
152PRKAA20.29586708
153TAOK30.27628869

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.11950319
2Basal cell carcinoma_Homo sapiens_hsa052172.60086166
3Nicotine addiction_Homo sapiens_hsa050332.49387735
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.20274314
5Hedgehog signaling pathway_Homo sapiens_hsa043402.05128196
6Axon guidance_Homo sapiens_hsa043602.04947314
7Glutamatergic synapse_Homo sapiens_hsa047242.04103123
8Insulin secretion_Homo sapiens_hsa049112.00356688
9Circadian entrainment_Homo sapiens_hsa047131.99988157
10Amphetamine addiction_Homo sapiens_hsa050311.98463372
11GABAergic synapse_Homo sapiens_hsa047271.88099922
12Melanogenesis_Homo sapiens_hsa049161.83460920
13Taste transduction_Homo sapiens_hsa047421.82463901
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.80965434
15Long-term potentiation_Homo sapiens_hsa047201.80711528
16Wnt signaling pathway_Homo sapiens_hsa043101.79154182
17Morphine addiction_Homo sapiens_hsa050321.63698366
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.60327741
19Dopaminergic synapse_Homo sapiens_hsa047281.59767878
20Hippo signaling pathway_Homo sapiens_hsa043901.57414107
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53695637
22Synaptic vesicle cycle_Homo sapiens_hsa047211.52434934
23Long-term depression_Homo sapiens_hsa047301.44784056
24Cholinergic synapse_Homo sapiens_hsa047251.44340022
25Fatty acid biosynthesis_Homo sapiens_hsa000611.42665103
26Cocaine addiction_Homo sapiens_hsa050301.40162095
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.39709462
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.37126787
29Type II diabetes mellitus_Homo sapiens_hsa049301.36430059
30Adherens junction_Homo sapiens_hsa045201.33236942
31Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.31079289
32Serotonergic synapse_Homo sapiens_hsa047261.29256609
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28597013
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26434783
35Selenocompound metabolism_Homo sapiens_hsa004501.25062205
36Estrogen signaling pathway_Homo sapiens_hsa049151.24916168
37Gastric acid secretion_Homo sapiens_hsa049711.22545677
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22117826
39Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.20898554
40Endometrial cancer_Homo sapiens_hsa052131.17176681
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17105901
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16603006
43Protein digestion and absorption_Homo sapiens_hsa049741.16161523
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.14141183
45Notch signaling pathway_Homo sapiens_hsa043301.13080792
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12602821
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12584591
48cAMP signaling pathway_Homo sapiens_hsa040241.12574804
49Olfactory transduction_Homo sapiens_hsa047401.11240210
50Circadian rhythm_Homo sapiens_hsa047101.10977129
51Tight junction_Homo sapiens_hsa045301.10458753
52Phototransduction_Homo sapiens_hsa047441.10296638
53Cardiac muscle contraction_Homo sapiens_hsa042601.09980982
54Salivary secretion_Homo sapiens_hsa049701.09681181
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08221502
56Colorectal cancer_Homo sapiens_hsa052101.07396287
57Oxytocin signaling pathway_Homo sapiens_hsa049211.06317865
58ECM-receptor interaction_Homo sapiens_hsa045121.05846843
59TGF-beta signaling pathway_Homo sapiens_hsa043501.05707456
60Thyroid cancer_Homo sapiens_hsa052161.02642114
61Renin secretion_Homo sapiens_hsa049241.02530410
62Gap junction_Homo sapiens_hsa045401.00377302
63Dilated cardiomyopathy_Homo sapiens_hsa054140.99479723
64Histidine metabolism_Homo sapiens_hsa003400.99383770
65Thyroid hormone synthesis_Homo sapiens_hsa049180.98633938
66Sulfur relay system_Homo sapiens_hsa041220.98296371
67Tryptophan metabolism_Homo sapiens_hsa003800.96886242
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95446699
69Nitrogen metabolism_Homo sapiens_hsa009100.93949352
70Focal adhesion_Homo sapiens_hsa045100.93881662
71Calcium signaling pathway_Homo sapiens_hsa040200.91206091
72Vitamin digestion and absorption_Homo sapiens_hsa049770.89780817
73Prostate cancer_Homo sapiens_hsa052150.89168325
74Oocyte meiosis_Homo sapiens_hsa041140.87580308
75ABC transporters_Homo sapiens_hsa020100.87069486
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86684972
77Small cell lung cancer_Homo sapiens_hsa052220.86213129
78GnRH signaling pathway_Homo sapiens_hsa049120.85264311
79ErbB signaling pathway_Homo sapiens_hsa040120.84836906
80Pancreatic secretion_Homo sapiens_hsa049720.84513050
81mRNA surveillance pathway_Homo sapiens_hsa030150.84259839
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82864137
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82315245
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80880820
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80382623
86Proteoglycans in cancer_Homo sapiens_hsa052050.79955926
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79833268
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79330802
89Renin-angiotensin system_Homo sapiens_hsa046140.79316593
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.78651977
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78243221
92Systemic lupus erythematosus_Homo sapiens_hsa053220.77811178
93FoxO signaling pathway_Homo sapiens_hsa040680.76777503
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76668778
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76592491
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.76398697
97Alzheimers disease_Homo sapiens_hsa050100.75973565
98PPAR signaling pathway_Homo sapiens_hsa033200.74730244
99Pathways in cancer_Homo sapiens_hsa052000.74079015
100Glioma_Homo sapiens_hsa052140.72452654
101Chemical carcinogenesis_Homo sapiens_hsa052040.72432822
102Rap1 signaling pathway_Homo sapiens_hsa040150.72421893
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71450942
104MAPK signaling pathway_Homo sapiens_hsa040100.71413110
105Chronic myeloid leukemia_Homo sapiens_hsa052200.69082054
106Ovarian steroidogenesis_Homo sapiens_hsa049130.68661067
107Sulfur metabolism_Homo sapiens_hsa009200.67202499
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67100018
109MicroRNAs in cancer_Homo sapiens_hsa052060.66931142
110HTLV-I infection_Homo sapiens_hsa051660.64621094
111Ras signaling pathway_Homo sapiens_hsa040140.64502250
112Glycerolipid metabolism_Homo sapiens_hsa005610.64481493
113Vibrio cholerae infection_Homo sapiens_hsa051100.61420113
114Folate biosynthesis_Homo sapiens_hsa007900.60907900
115Huntingtons disease_Homo sapiens_hsa050160.59561104
116Alcoholism_Homo sapiens_hsa050340.59005330
117Oxidative phosphorylation_Homo sapiens_hsa001900.58841770
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57595645
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57508619
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56776545
121Dorso-ventral axis formation_Homo sapiens_hsa043200.55996357
122Fanconi anemia pathway_Homo sapiens_hsa034600.55831761
123Propanoate metabolism_Homo sapiens_hsa006400.55039728
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.54161120
125Prolactin signaling pathway_Homo sapiens_hsa049170.53954710
126Amoebiasis_Homo sapiens_hsa051460.53131037
127Ether lipid metabolism_Homo sapiens_hsa005650.53099741
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.53046672
129Pancreatic cancer_Homo sapiens_hsa052120.52994897
130Glucagon signaling pathway_Homo sapiens_hsa049220.52549156
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52462725
132Inositol phosphate metabolism_Homo sapiens_hsa005620.52345975
133beta-Alanine metabolism_Homo sapiens_hsa004100.51854471
134RNA degradation_Homo sapiens_hsa030180.51634807
135Butanoate metabolism_Homo sapiens_hsa006500.49388236
136Parkinsons disease_Homo sapiens_hsa050120.44425292
137Mineral absorption_Homo sapiens_hsa049780.44079997
138Melanoma_Homo sapiens_hsa052180.43495305
139Bile secretion_Homo sapiens_hsa049760.40019192
140Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38556256
141Ribosome_Homo sapiens_hsa030100.38486062

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