ADAMTS19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS16, another family member. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)5.69835128
2regulation of cardioblast differentiation (GO:0051890)5.10317012
3regulation of gene silencing by RNA (GO:0060966)4.68313327
4regulation of posttranscriptional gene silencing (GO:0060147)4.68313327
5regulation of gene silencing by miRNA (GO:0060964)4.68313327
6myofibril assembly (GO:0030239)4.60132433
7pre-miRNA processing (GO:0031054)4.47265389
8atrial septum morphogenesis (GO:0060413)4.42120482
9regulation of transforming growth factor beta2 production (GO:0032909)4.37950470
10chromatin remodeling at centromere (GO:0031055)4.31121421
11endocardial cushion morphogenesis (GO:0003203)4.29788812
12establishment of integrated proviral latency (GO:0075713)4.25252661
13mesenchyme morphogenesis (GO:0072132)4.25121711
14negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.17218071
15CENP-A containing nucleosome assembly (GO:0034080)4.13570445
16lung-associated mesenchyme development (GO:0060484)4.04264448
17lateral sprouting from an epithelium (GO:0060601)3.99887766
18regulation of heart morphogenesis (GO:2000826)3.95019372
19bone trabecula formation (GO:0060346)3.88992215
20negative regulation of potassium ion transmembrane transport (GO:1901380)3.86137352
21endocardial cushion development (GO:0003197)3.85181638
22cardiac muscle cell development (GO:0055013)3.81885459
23paraxial mesoderm development (GO:0048339)3.79877389
24cardiac cell development (GO:0055006)3.78522454
25outflow tract septum morphogenesis (GO:0003148)3.76448656
26planar cell polarity pathway involved in neural tube closure (GO:0090179)3.76413053
27heterochromatin organization (GO:0070828)3.75989432
28extracellular fibril organization (GO:0043206)3.74056395
29positive regulation of SMAD protein import into nucleus (GO:0060391)3.71489109
30histone exchange (GO:0043486)3.66486118
31regulation of centriole replication (GO:0046599)3.62109236
32regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.55235220
33cardiac right ventricle morphogenesis (GO:0003215)3.54305485
34protein localization to kinetochore (GO:0034501)3.52643799
35regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.52082345
36regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.49545009
37DNA replication-independent nucleosome assembly (GO:0006336)3.49016519
38DNA replication-independent nucleosome organization (GO:0034724)3.49016519
39regulation of secondary heart field cardioblast proliferation (GO:0003266)3.47834301
40regulation of cardioblast proliferation (GO:0003264)3.47834301
41ventricular cardiac muscle cell development (GO:0055015)3.45997005
42negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.44427486
43regulation of cell fate specification (GO:0042659)3.44126416
44insulin-like growth factor receptor signaling pathway (GO:0048009)3.43959620
45regulation of helicase activity (GO:0051095)3.41170451
46DNA replication checkpoint (GO:0000076)3.40227766
47L-serine metabolic process (GO:0006563)3.38620060
48anterior/posterior axis specification, embryo (GO:0008595)3.37270841
49heart trabecula formation (GO:0060347)3.36999523
50sarcomere organization (GO:0045214)3.35801724
51dorsal/ventral axis specification (GO:0009950)3.35670648
52cardiac muscle cell proliferation (GO:0060038)3.35237355
53heart valve formation (GO:0003188)3.32202834
54trabecula formation (GO:0060343)3.32069728
55positive regulation of cardiac muscle cell proliferation (GO:0060045)3.31658930
56heart morphogenesis (GO:0003007)3.28658544
57negative regulation of striated muscle cell apoptotic process (GO:0010664)3.27829270
58regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.26215963
59cardiac muscle hypertrophy (GO:0003300)3.26156121
60muscle filament sliding (GO:0030049)3.25890650
61actin-myosin filament sliding (GO:0033275)3.25890650
62nuclear pore complex assembly (GO:0051292)3.24568620
63ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.23358988
64protein complex localization (GO:0031503)3.22978728
65establishment of apical/basal cell polarity (GO:0035089)3.22030861
66regulation of sarcomere organization (GO:0060297)3.20812405
67regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.19573847
68regulation of mitotic spindle checkpoint (GO:1903504)3.19573847
69IMP biosynthetic process (GO:0006188)3.19056242
70cardiac muscle tissue morphogenesis (GO:0055008)3.18848262
71mesenchyme development (GO:0060485)3.18840575
72regulation of somitogenesis (GO:0014807)3.18191219
73adult heart development (GO:0007512)3.13679534
74mitotic metaphase plate congression (GO:0007080)3.13378425
75regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.13197848
76nuclear pore organization (GO:0006999)3.13177220
77Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.13039699
78negative regulation of catenin import into nucleus (GO:0035414)3.12253741
79non-canonical Wnt signaling pathway (GO:0035567)3.11735161
80hippo signaling (GO:0035329)3.10311413
81negative regulation of chondrocyte differentiation (GO:0032331)3.09544171
82negative regulation of translation, ncRNA-mediated (GO:0040033)3.07990608
83regulation of translation, ncRNA-mediated (GO:0045974)3.07990608
84negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.07990608
85notochord development (GO:0030903)3.07717653
86actomyosin structure organization (GO:0031032)3.04567162
87cochlea morphogenesis (GO:0090103)3.04382221
88regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.04273973
89striated muscle hypertrophy (GO:0014897)3.04239220
90negative regulation of chromosome segregation (GO:0051985)3.03875246
91negative regulation of mitotic sister chromatid separation (GO:2000816)3.03366366
92negative regulation of sister chromatid segregation (GO:0033046)3.03366366
93negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.03366366
94negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.03366366
95negative regulation of mitotic sister chromatid segregation (GO:0033048)3.03366366
96gastrulation with mouth forming second (GO:0001702)3.03343772
97establishment of tissue polarity (GO:0007164)3.03320195
98establishment of planar polarity (GO:0001736)3.03320195
99positive regulation of cardiac muscle tissue growth (GO:0055023)3.02695759
100establishment of viral latency (GO:0019043)3.01748491
101gap junction assembly (GO:0016264)3.01315657
102regulation of establishment of planar polarity (GO:0090175)3.00985066
103prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.00635461
104mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.00564994
105DNA strand elongation involved in DNA replication (GO:0006271)2.99009866
106glucocorticoid receptor signaling pathway (GO:0042921)2.97457526
107muscle tissue morphogenesis (GO:0060415)2.96977721
108actin-mediated cell contraction (GO:0070252)2.96691929
109anatomical structure regression (GO:0060033)2.96613357
110outer ear morphogenesis (GO:0042473)2.96304033
111L-alpha-amino acid transmembrane transport (GO:1902475)2.95934390
112heart valve morphogenesis (GO:0003179)2.93141684
113mitotic sister chromatid cohesion (GO:0007064)2.91939926
114IMP metabolic process (GO:0046040)2.91556562
115extracellular matrix assembly (GO:0085029)2.91135228
116ATP-dependent chromatin remodeling (GO:0043044)2.91084932
117cardiac muscle adaptation (GO:0014887)2.90345936
118cardiac muscle hypertrophy in response to stress (GO:0014898)2.90345936
119muscle hypertrophy in response to stress (GO:0003299)2.90345936
120branching involved in salivary gland morphogenesis (GO:0060445)2.89614185
121cell migration involved in heart development (GO:0060973)2.89233214
122fibril organization (GO:0097435)2.88286970
123negative regulation of DNA-dependent DNA replication (GO:2000104)2.87527155
124protein heterotrimerization (GO:0070208)2.86446108
125embryonic foregut morphogenesis (GO:0048617)2.86313693
126regulation of non-canonical Wnt signaling pathway (GO:2000050)2.86254056
127DNA strand elongation (GO:0022616)2.85543243
128epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.85230438
129cell proliferation involved in metanephros development (GO:0072203)2.83147802
130somatic diversification of immune receptors via somatic mutation (GO:0002566)2.83004329
131somatic hypermutation of immunoglobulin genes (GO:0016446)2.83004329
132spindle checkpoint (GO:0031577)2.82187423
133cardiac muscle contraction (GO:0060048)2.81641218
134sequestering of extracellular ligand from receptor (GO:0035581)2.81499025
135DNA replication-dependent nucleosome assembly (GO:0006335)2.81100067
136DNA replication-dependent nucleosome organization (GO:0034723)2.81100067
137positive regulation of cardiac muscle tissue development (GO:0055025)2.81028951
138muscle cell proliferation (GO:0033002)2.80539889
139head development (GO:0060322)2.80280456
140DNA unwinding involved in DNA replication (GO:0006268)2.78894534
141mitotic spindle checkpoint (GO:0071174)2.78844573
142establishment of monopolar cell polarity (GO:0061162)2.78759927
143establishment or maintenance of monopolar cell polarity (GO:0061339)2.78759927
144regulation of cardiac muscle tissue growth (GO:0055021)2.78218727
145DNA ligation (GO:0006266)2.77875548
146female gonad development (GO:0008585)2.77793877
147organ formation (GO:0048645)2.77094134
148convergent extension (GO:0060026)2.76986286
149midgut development (GO:0007494)2.76009224
150striated muscle cell proliferation (GO:0014855)2.74716415
151regulation of cardiac muscle cell proliferation (GO:0060043)2.74158406
152regulation of chromosome segregation (GO:0051983)2.73713712
153regulation of nuclear cell cycle DNA replication (GO:0033262)2.73512496
154gonadal mesoderm development (GO:0007506)2.73444973
155regulation of potassium ion transmembrane transporter activity (GO:1901016)2.72958424
156double-strand break repair via nonhomologous end joining (GO:0006303)2.72641971
157non-recombinational repair (GO:0000726)2.72641971
158negative regulation of cartilage development (GO:0061037)2.72146957
159purine nucleobase biosynthetic process (GO:0009113)2.71434621
160mesenchymal cell differentiation involved in renal system development (GO:2001012)2.71201184
161mesenchymal cell differentiation involved in kidney development (GO:0072161)2.71201184
162regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.71000653
163positive regulation of catenin import into nucleus (GO:0035413)2.70649913
164negative regulation of embryonic development (GO:0045992)2.70450454
165cell surface receptor signaling pathway involved in heart development (GO:0061311)2.70205423
166establishment of nucleus localization (GO:0040023)2.70042134
167DNA double-strand break processing (GO:0000729)2.69653146
168polarized epithelial cell differentiation (GO:0030859)2.69427729
169negative regulation of DNA repair (GO:0045738)2.68212382
170negative regulation of androgen receptor signaling pathway (GO:0060766)2.67836538
171negative regulation of cell fate specification (GO:0009996)2.67519363
172negative regulation of mitosis (GO:0045839)2.66227574
173regulation of mitotic sister chromatid separation (GO:0010965)2.65703644
174regulation of mitotic sister chromatid segregation (GO:0033047)2.65703644
175regulation of sister chromatid segregation (GO:0033045)2.65703644
176regulation of mitotic metaphase/anaphase transition (GO:0030071)2.64752477
177regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.64752477
178regulation of histone H3-K9 methylation (GO:0051570)2.64337259
179bundle of His cell to Purkinje myocyte communication (GO:0086069)2.63773847
180regulation of centrosome cycle (GO:0046605)2.63743392
181regulation of cell fate commitment (GO:0010453)2.63247179
182metaphase plate congression (GO:0051310)2.63178047
183mitotic G2/M transition checkpoint (GO:0044818)2.63038525
184mitotic spindle assembly checkpoint (GO:0007094)2.62526668
185protein localization to chromosome, centromeric region (GO:0071459)2.61428700
186regulation of stem cell maintenance (GO:2000036)2.61386575
187negative regulation of cell fate commitment (GO:0010454)2.61176274
188telomere maintenance via semi-conservative replication (GO:0032201)2.60771076
189regulation of gene silencing (GO:0060968)2.58759156
190nucleobase biosynthetic process (GO:0046112)2.58259476
191DNA damage response, detection of DNA damage (GO:0042769)2.57415413

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.22093119
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.60353932
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.50339738
4EP300_21415370_ChIP-Seq_HL-1_Mouse3.46727019
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.37135922
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.36027431
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.18591103
8TRIM28_21343339_ChIP-Seq_HEK293_Human3.18117187
9CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.95766324
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.93513515
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.88060979
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.88060979
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.88060979
14EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.86610785
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.69136580
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.59041216
17* ISL1_27105846_Chip-Seq_CPCs_Mouse2.46300616
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.41080603
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.38946030
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.36606370
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28335717
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.26957070
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.25678280
24NANOG_16153702_ChIP-ChIP_HESCs_Human2.25586686
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.24401624
26MYC_19030024_ChIP-ChIP_MESCs_Mouse2.22257737
27* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.21914622
28HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.20442131
29TP63_19390658_ChIP-ChIP_HaCaT_Human2.13970110
30ESR1_20079471_ChIP-ChIP_T-47D_Human2.13049315
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.11419267
32* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.11341423
33* SOX2_16153702_ChIP-ChIP_HESCs_Human2.10731469
34POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.07857320
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.01941596
36* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.97992970
37* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.97992970
38NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.97935877
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.96344857
40* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.88996865
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.87039628
42WT1_19549856_ChIP-ChIP_CCG9911_Human1.86114486
43DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.85773688
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.82972537
45EZH2_22144423_ChIP-Seq_EOC_Human1.82694888
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.78471090
47* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.75941742
48* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.75005451
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.74730085
50CLOCK_20551151_ChIP-Seq_293T_Human1.74446941
51ELK1_19687146_ChIP-ChIP_HELA_Human1.74376442
52AR_21909140_ChIP-Seq_LNCAP_Human1.72156999
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71494213
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69504942
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.66955664
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65744192
57FUS_26573619_Chip-Seq_HEK293_Human1.62398298
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62244178
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62043334
60TCF3_18692474_ChIP-Seq_MEFs_Mouse1.61507438
61FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.59707401
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57890989
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57801044
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.56530559
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.55790292
66MYC_18358816_ChIP-ChIP_MESCs_Mouse1.55266269
67TCF3_18692474_ChIP-Seq_MESCs_Mouse1.53583227
68* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.53547109
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53074824
70* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.52238196
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51889217
72SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.49857841
73TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.48666674
74ZFP281_18757296_ChIP-ChIP_E14_Mouse1.48572069
75* RNF2_27304074_Chip-Seq_ESCs_Mouse1.48337689
76KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.47934924
77TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.47927356
78WT1_25993318_ChIP-Seq_PODOCYTE_Human1.44075449
79CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.43937048
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43218332
81TBX20_22080862_ChIP-Seq_HEART_Mouse1.42645601
82TBX20_22328084_ChIP-Seq_HEART_Mouse1.42645601
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40788303
84E2F1_18555785_ChIP-Seq_MESCs_Mouse1.40189752
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40078580
86GATA1_26923725_Chip-Seq_HPCs_Mouse1.39839704
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39801192
88* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.35909898
89MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.33666928
90NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.33197608
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.33182082
92* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32876068
93EGR1_19374776_ChIP-ChIP_THP-1_Human1.32655845
94RING1B_27294783_Chip-Seq_NPCs_Mouse1.32359426
95EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30759321
96JARID2_20075857_ChIP-Seq_MESCs_Mouse1.30561943
97BRD4_25478319_ChIP-Seq_HGPS_Human1.26643642
98TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.25405639
99E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24085906
100ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.23941005
101ETS1_20019798_ChIP-Seq_JURKAT_Human1.23531009
102ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23138906
103PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22903731
104RING1B_27294783_Chip-Seq_ESCs_Mouse1.22444675
105* P300_19829295_ChIP-Seq_ESCs_Human1.22022327
106POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21921646
107ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21814653
108ESR1_21235772_ChIP-Seq_MCF-7_Human1.21389506
109TTF2_22483619_ChIP-Seq_HELA_Human1.21153115
110NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19879185
111CBX2_27304074_Chip-Seq_ESCs_Mouse1.19878249
112THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16567036
113* TP53_20018659_ChIP-ChIP_R1E_Mouse1.16260903
114ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16079237
115GATA4_21415370_ChIP-Seq_HL-1_Mouse1.15386140
116PIAS1_25552417_ChIP-Seq_VCAP_Human1.14274987
117SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13575042
118EWS_26573619_Chip-Seq_HEK293_Human1.12983186
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12821967
120NANOG_21062744_ChIP-ChIP_HESCs_Human1.12036720
121* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11824339
122ARNT_22903824_ChIP-Seq_MCF-7_Human1.11374322
123TBX3_20139965_ChIP-Seq_ESCs_Mouse1.10491034
124MYC_18940864_ChIP-ChIP_HL60_Human1.10392759
125CJUN_26792858_Chip-Seq_BT549_Human1.10288192
126TBX3_20139965_ChIP-Seq_MESCs_Mouse1.09650304
127FLI1_27457419_Chip-Seq_LIVER_Mouse1.08744190
128ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07997221
129SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07654366
130FOXP3_21729870_ChIP-Seq_TREG_Human1.06817189
131NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.05490673
132POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.04771315
133NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04640859
134ZNF274_21170338_ChIP-Seq_K562_Hela1.04328145
135YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03937170
136SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03518184
137NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.02717167
138SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01759867
139SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01433118
140SOX17_20123909_ChIP-Seq_XEN_Mouse1.01412065
141JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.00792952
142XRN2_22483619_ChIP-Seq_HELA_Human1.00076521
143BCAT_22108803_ChIP-Seq_LS180_Human0.99953872
144SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99279688
145ESR2_21235772_ChIP-Seq_MCF-7_Human0.98677166
146TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98279159
147TAF15_26573619_Chip-Seq_HEK293_Human0.97642724
148STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97509956
149AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97445947
150TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.96481956
151HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96297912
152EZH2_27294783_Chip-Seq_ESCs_Mouse0.96025107
153AHR_22903824_ChIP-Seq_MCF-7_Human0.95784058
154KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95262618
155TCF4_18268006_ChIP-ChIP_LS174T_Human0.94883695
156PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94370320
157* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94367137
158* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.94288797
159FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94283527
160SMAD3_21741376_ChIP-Seq_EPCs_Human0.93955262
161PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93810619
162BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93102626
163DCP1A_22483619_ChIP-Seq_HELA_Human0.90966957
164AR_19668381_ChIP-Seq_PC3_Human0.90847698
165RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90824838
166CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90146882
167CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90136549
168IRF1_19129219_ChIP-ChIP_H3396_Human0.90033639
169STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.88121469
170MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.85975968
171NANOG_16518401_ChIP-PET_MESCs_Mouse0.85865539
172PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.83036177
173ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.80348065

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat3.32425173
2MP0003693_abnormal_embryo_hatching3.13459952
3MP0003890_abnormal_embryonic-extraembry3.06354328
4MP0003122_maternal_imprinting2.92584613
5MP0004957_abnormal_blastocyst_morpholog2.87756959
6MP0004084_abnormal_cardiac_muscle2.79651062
7MP0005503_abnormal_tendon_morphology2.69896742
8MP0000537_abnormal_urethra_morphology2.69831406
9MP0003123_paternal_imprinting2.66505725
10MP0008438_abnormal_cutaneous_collagen2.65696134
11MP0008057_abnormal_DNA_replication2.48730624
12MP0010030_abnormal_orbit_morphology2.47471206
13MP0004272_abnormal_basement_membrane2.46825776
14MP0003941_abnormal_skin_development2.43960372
15MP0004264_abnormal_extraembryonic_tissu2.38437341
16MP0002249_abnormal_larynx_morphology2.35734237
17MP0010094_abnormal_chromosome_stability2.32239402
18MP0009672_abnormal_birth_weight2.31870557
19MP0009250_abnormal_appendicular_skeleto2.28432197
20MP0003567_abnormal_fetal_cardiomyocyte2.21769270
21MP0003121_genomic_imprinting2.20942535
22MP0002938_white_spotting2.18535974
23MP0003385_abnormal_body_wall2.12805990
24MP0003115_abnormal_respiratory_system2.12063802
25MP0003111_abnormal_nucleus_morphology2.08908326
26MP0003942_abnormal_urinary_system2.07438807
27MP0005248_abnormal_Harderian_gland2.06359612
28MP0005367_renal/urinary_system_phenotyp2.00655860
29MP0000516_abnormal_urinary_system2.00655860
30MP0002282_abnormal_trachea_morphology2.00571580
31MP0000751_myopathy1.97710483
32MP0009053_abnormal_anal_canal1.95461857
33MP0002697_abnormal_eye_size1.95336216
34MP0003705_abnormal_hypodermis_morpholog1.93391850
35MP0006292_abnormal_olfactory_placode1.89054572
36MP0000049_abnormal_middle_ear1.82192477
37MP0008932_abnormal_embryonic_tissue1.81490694
38MP0002932_abnormal_joint_morphology1.81191120
39MP0003077_abnormal_cell_cycle1.76983168
40MP0000428_abnormal_craniofacial_morphol1.76821637
41MP0009384_cardiac_valve_regurgitation1.74743088
42MP0005623_abnormal_meninges_morphology1.74031027
43MP0004215_abnormal_myocardial_fiber1.73706158
44MP0008058_abnormal_DNA_repair1.73443654
45MP0005275_abnormal_skin_tensile1.71989792
46MP0000534_abnormal_ureter_morphology1.69137928
47MP0005377_hearing/vestibular/ear_phenot1.68377690
48MP0003878_abnormal_ear_physiology1.68377690
49MP0005508_abnormal_skeleton_morphology1.66482635
50MP0006138_congestive_heart_failure1.65994349
51MP0000733_abnormal_muscle_development1.64051301
52MP0003937_abnormal_limbs/digits/tail_de1.63787450
53MP0003935_abnormal_craniofacial_develop1.62959853
54MP0008877_abnormal_DNA_methylation1.62737744
55MP0004036_abnormal_muscle_relaxation1.61101629
56MP0001730_embryonic_growth_arrest1.57280354
57MP0005330_cardiomyopathy1.56898141
58MP0000579_abnormal_nail_morphology1.55412473
59MP0009703_decreased_birth_body1.54879870
60MP0002972_abnormal_cardiac_muscle1.53433900
61MP0000566_synostosis1.52421533
62MP0001286_abnormal_eye_development1.49265820
63MP0010630_abnormal_cardiac_muscle1.48969145
64MP0003119_abnormal_digestive_system1.46086150
65MP0008775_abnormal_heart_ventricle1.44885100
66MP0010368_abnormal_lymphatic_system1.44469077
67MP0003718_maternal_effect1.40969759
68MP0006054_spinal_hemorrhage1.40225464
69MP0002127_abnormal_cardiovascular_syste1.38727348
70MP0001293_anophthalmia1.38312311
71MP0002233_abnormal_nose_morphology1.37948783
72MP0003755_abnormal_palate_morphology1.37894664
73MP0003137_abnormal_impulse_conducting1.36113962
74MP0004133_heterotaxia1.35868057
75MP0000762_abnormal_tongue_morphology1.33892835
76MP0001697_abnormal_embryo_size1.30778950
77MP0000383_abnormal_hair_follicle1.30492627
78MP0005385_cardiovascular_system_phenoty1.27802917
79MP0001544_abnormal_cardiovascular_syste1.27802917
80MP0004087_abnormal_muscle_fiber1.27185369
81MP0002837_dystrophic_cardiac_calcinosis1.26541292
82MP0002116_abnormal_craniofacial_bone1.26292194
83MP0005187_abnormal_penis_morphology1.24637158
84MP0002751_abnormal_autonomic_nervous1.24617812
85MP0003828_pulmonary_edema1.22233240
86MP0001485_abnormal_pinna_reflex1.21794447
87MP0010678_abnormal_skin_adnexa1.18855826
88MP0004197_abnormal_fetal_growth/weight/1.17552411
89MP0001958_emphysema1.15547237
90MP0002109_abnormal_limb_morphology1.14792994
91MP0002111_abnormal_tail_morphology1.12999511
92MP0005620_abnormal_muscle_contractility1.11144911
93MP0000432_abnormal_head_morphology1.10224267
94MP0000163_abnormal_cartilage_morphology1.09567282
95MP0003315_abnormal_perineum_morphology1.09065095
96MP0010307_abnormal_tumor_latency1.08821675
97MP0001188_hyperpigmentation1.05162974
98MP0001177_atelectasis1.04988510
99MP0001529_abnormal_vocalization1.04902442
100MP0010352_gastrointestinal_tract_polyps1.04381694
101MP0002092_abnormal_eye_morphology1.04215901
102MP0000350_abnormal_cell_proliferation1.03893553
103MP0002234_abnormal_pharynx_morphology1.03885672
104MP0003861_abnormal_nervous_system1.03389421
105MP0003566_abnormal_cell_adhesion1.03222789
106MP0004145_abnormal_muscle_electrophysio1.02943361
107MP0002796_impaired_skin_barrier1.02770138
108MP0000462_abnormal_digestive_system1.02225074
109MP0003136_yellow_coat_color1.01992463
110MP0002115_abnormal_skeleton_extremities1.01973682
111MP0002085_abnormal_embryonic_tissue1.01013038
112MP0002080_prenatal_lethality1.00049859
113MP0000266_abnormal_heart_morphology0.99944972
114MP0000647_abnormal_sebaceous_gland0.99836578
115MP0002114_abnormal_axial_skeleton0.99701612
116MP0002102_abnormal_ear_morphology0.99521493
117MP0002108_abnormal_muscle_morphology0.99142054
118MP0002925_abnormal_cardiovascular_devel0.97400015
119MP0002086_abnormal_extraembryonic_tissu0.95104220
120MP0002088_abnormal_embryonic_growth/wei0.95004897
121MP0002098_abnormal_vibrissa_morphology0.93749074
122MP0000767_abnormal_smooth_muscle0.93394234
123MP0001849_ear_inflammation0.93290632
124MP0002084_abnormal_developmental_patter0.93083020
125MP0003938_abnormal_ear_development0.92253011
126MP0003984_embryonic_growth_retardation0.91788869
127MP0000026_abnormal_inner_ear0.91384365
128MP0003279_aneurysm0.91053935
129MP0001175_abnormal_lung_morphology0.91036902
130MP0003879_abnormal_hair_cell0.90490159
131MP0005076_abnormal_cell_differentiation0.89914558
132MP0004484_altered_response_of0.89609172
133MP0002106_abnormal_muscle_physiology0.89276418
134MP0005380_embryogenesis_phenotype0.89189551
135MP0001672_abnormal_embryogenesis/_devel0.89189551
136MP0004233_abnormal_muscle_weight0.89100967
137MP0003221_abnormal_cardiomyocyte_apopto0.86227512
138MP0008007_abnormal_cellular_replicative0.85868422
139MP0001299_abnormal_eye_distance/0.85299400
140MP0005369_muscle_phenotype0.84096652
141MP0002736_abnormal_nociception_after0.83605151
142MP0009697_abnormal_copulation0.82283022
143MP0003283_abnormal_digestive_organ0.79282524
144MP0003936_abnormal_reproductive_system0.76194734
145MP0006072_abnormal_retinal_apoptosis0.75613251
146MP0005391_vision/eye_phenotype0.73121840
147MP0001145_abnormal_male_reproductive0.70418425
148MP0001340_abnormal_eyelid_morphology0.67930041
149MP0002210_abnormal_sex_determination0.66343238
150MP0003787_abnormal_imprinting0.64296609

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)4.26651505
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.26651505
3Abnormal lung lobation (HP:0002101)3.68798524
4Choanal stenosis (HP:0000452)3.58132584
5Bell-shaped thorax (HP:0001591)3.54579956
6Midline defect of the nose (HP:0004122)3.48243811
7Abnormality of the 4th metacarpal (HP:0010012)3.46681634
8Sudden death (HP:0001699)3.41554664
9Subaortic stenosis (HP:0001682)3.40638224
10Abnormality of the left ventricular outflow tract (HP:0011103)3.40638224
11Subacute progressive viral hepatitis (HP:0006572)3.34992996
12Renal duplication (HP:0000075)3.23942318
13Nephroblastoma (Wilms tumor) (HP:0002667)3.19546177
14Abnormality of the labia minora (HP:0012880)3.19246322
15Type 1 muscle fiber predominance (HP:0003803)3.16669161
16Ankle contracture (HP:0006466)3.15812973
17Bicornuate uterus (HP:0000813)3.12525623
18Epiphyseal dysplasia (HP:0002656)3.08773730
19Chromosomal breakage induced by crosslinking agents (HP:0003221)3.07095923
20Protrusio acetabuli (HP:0003179)3.05668828
21Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.00775386
22Chromsome breakage (HP:0040012)2.96003392
23Shallow orbits (HP:0000586)2.94128922
24Vitreoretinal degeneration (HP:0000655)2.92870485
25Septo-optic dysplasia (HP:0100842)2.90217586
26Hypoplastic ischia (HP:0003175)2.89155456
27Intestinal atresia (HP:0011100)2.81370958
28Meckel diverticulum (HP:0002245)2.73681885
29Periauricular skin pits (HP:0100277)2.68346600
30Preauricular pit (HP:0004467)2.68346600
31Anophthalmia (HP:0000528)2.67302013
32Broad metatarsal (HP:0001783)2.65611179
33Abnormality of the ileum (HP:0001549)2.62598445
34Scapular winging (HP:0003691)2.59767961
35Abnormality of the ischium (HP:0003174)2.55935844
36Stenosis of the external auditory canal (HP:0000402)2.55617664
37Abnormality of the pubic bones (HP:0003172)2.48299284
38Pulmonary artery stenosis (HP:0004415)2.47531297
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.44981745
40Facial cleft (HP:0002006)2.44870286
41Abnormality of the calf musculature (HP:0001430)2.44027424
42Lymphangioma (HP:0100764)2.42896630
43Morphological abnormality of the middle ear (HP:0008609)2.42515137
44Abnormality of the lacrimal duct (HP:0011481)2.41911598
45Aortic dissection (HP:0002647)2.40762578
46Abnormality of the nasolacrimal system (HP:0000614)2.40324050
47Skin pits (HP:0100276)2.39046971
48Myelomeningocele (HP:0002475)2.38566619
49Asymmetry of the thorax (HP:0001555)2.36051677
50Abnormality of chromosome stability (HP:0003220)2.35512815
51High anterior hairline (HP:0009890)2.34714782
52Rectal prolapse (HP:0002035)2.33490796
53Triphalangeal thumb (HP:0001199)2.33230478
54Atrial fibrillation (HP:0005110)2.31636140
55Right ventricular cardiomyopathy (HP:0011663)2.29465671
56Absent radius (HP:0003974)2.28236304
57Sprengel anomaly (HP:0000912)2.27493335
58Ventricular tachycardia (HP:0004756)2.27459582
59Clitoromegaly (HP:0000057)2.22921019
60Cutaneous finger syndactyly (HP:0010554)2.22822219
61Bicuspid aortic valve (HP:0001647)2.19565269
62Mesomelia (HP:0003027)2.18983868
63Hepatoblastoma (HP:0002884)2.17987720
64Birth length less than 3rd percentile (HP:0003561)2.16266341
65Abnormality of the duodenum (HP:0002246)2.16144833
66Bladder diverticulum (HP:0000015)2.15885798
67Renovascular hypertension (HP:0100817)2.15615746
68Reticulocytopenia (HP:0001896)2.15455728
69Exostoses (HP:0100777)2.13529317
70Premature rupture of membranes (HP:0001788)2.13195692
71Lipoatrophy (HP:0100578)2.12921194
72Mildly elevated creatine phosphokinase (HP:0008180)2.12887503
73Primary atrial arrhythmia (HP:0001692)2.12757523
74Maternal diabetes (HP:0009800)2.12468836
75Pancreatic islet-cell hyperplasia (HP:0004510)2.12210182
76Selective tooth agenesis (HP:0001592)2.11381482
77Absent forearm bone (HP:0003953)2.10061092
78Aplasia involving forearm bones (HP:0009822)2.10061092
79Absent hair (HP:0002298)2.09789393
80Partial duplication of thumb phalanx (HP:0009944)2.09304272
81Duodenal stenosis (HP:0100867)2.09196576
82Small intestinal stenosis (HP:0012848)2.09196576
83Breast carcinoma (HP:0003002)2.08621584
84Abnormality of the septum pellucidum (HP:0007375)2.08201243
85Rhabdomyosarcoma (HP:0002859)2.08013048
86Cutaneous syndactyly (HP:0012725)2.07464334
87Hyperglycinuria (HP:0003108)2.07284465
88Hyperglycinemia (HP:0002154)2.05699630
89Arterial tortuosity (HP:0005116)2.03677375
90Supraventricular arrhythmia (HP:0005115)2.03285302
91Multiple enchondromatosis (HP:0005701)2.01756086
92Mild short stature (HP:0003502)2.01566134
93Supraventricular tachycardia (HP:0004755)2.00641080
94Absent septum pellucidum (HP:0001331)2.00507643
95Esophageal atresia (HP:0002032)2.00218589
96Hip contracture (HP:0003273)1.99585082
97Skull defect (HP:0001362)1.99484998
98Severe Myopia (HP:0011003)1.99097415
99Gastrointestinal atresia (HP:0002589)1.97919041
100Spinal rigidity (HP:0003306)1.97387239
101Renal hypoplasia (HP:0000089)1.96562043
102Flat cornea (HP:0007720)1.95385926
103Ventricular arrhythmia (HP:0004308)1.95349762
104Abnormality of methionine metabolism (HP:0010901)1.95069008
105Short hallux (HP:0010109)1.95023955
106Abnormality of the preputium (HP:0100587)1.94652353
107Wide anterior fontanel (HP:0000260)1.93995501
108Absent eyebrow (HP:0002223)1.93854730
109Abnormality of the clitoris (HP:0000056)1.93419325
110Mixed hearing impairment (HP:0000410)1.92069766
111Bilateral microphthalmos (HP:0007633)1.90468622
112Gastrointestinal carcinoma (HP:0002672)1.90307693
113Malignant gastrointestinal tract tumors (HP:0006749)1.90307693
114Broad toe (HP:0001837)1.90082936
115Hyperacusis (HP:0010780)1.89933695
116Overriding aorta (HP:0002623)1.88443962
117Cupped ear (HP:0000378)1.88142044
118Aqueductal stenosis (HP:0002410)1.87420187
119Decreased lacrimation (HP:0000633)1.87208657
120Tracheal stenosis (HP:0002777)1.85495123
121Bifid tongue (HP:0010297)1.85376392
122Cerebral aneurysm (HP:0004944)1.85071176
123Duplication of thumb phalanx (HP:0009942)1.84840772
124Embryonal renal neoplasm (HP:0011794)1.84306969
125Preaxial foot polydactyly (HP:0001841)1.83600872
126Aortic aneurysm (HP:0004942)1.83193930
127Partial duplication of the phalanx of hand (HP:0009999)1.83133934
128Aplasia/Hypoplasia of the hallux (HP:0008362)1.83062339
129Ependymoma (HP:0002888)1.82829533
130Alacrima (HP:0000522)1.82651092
131Homocystinuria (HP:0002156)1.81895286
132Abnormality of homocysteine metabolism (HP:0010919)1.81895286
133Medulloblastoma (HP:0002885)1.81245546
134Patent foramen ovale (HP:0001655)1.81145182
135Uterine neoplasm (HP:0010784)1.81073568
136Mitral valve prolapse (HP:0001634)1.80482934
137Vaginal atresia (HP:0000148)1.80245264
138Short middle phalanx of the 5th finger (HP:0004220)1.80135112
139Missing ribs (HP:0000921)1.80004584
140Partial agenesis of the corpus callosum (HP:0001338)1.79851640
141Aplasia/Hypoplasia of the sacrum (HP:0008517)1.79448229
142Ectopic anus (HP:0004397)1.79397422
143Vascular tortuosity (HP:0004948)1.79331694
144Elfin facies (HP:0004428)1.78948236
145Increased variability in muscle fiber diameter (HP:0003557)1.78387307
146Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78142263
147Abnormality of the shoulder girdle musculature (HP:0001435)1.78107707
148Absent eyelashes (HP:0000561)1.77440962
149Curly hair (HP:0002212)1.77382500
150Colon cancer (HP:0003003)1.77146661
151Hypoplastic left heart (HP:0004383)1.76909637
152Omphalocele (HP:0001539)1.76861522
153Increased nuchal translucency (HP:0010880)1.76722557
154Abnormality of serine family amino acid metabolism (HP:0010894)1.76609314
155Abnormality of glycine metabolism (HP:0010895)1.76609314
156Abnormality of the parietal bone (HP:0002696)1.76580733
157Ectopic kidney (HP:0000086)1.76481687
158Spastic diplegia (HP:0001264)1.75798909
159Biliary tract neoplasm (HP:0100574)1.75749948
160Prolonged QT interval (HP:0001657)1.75388212
161Aplasia/Hypoplasia of the sternum (HP:0006714)1.75009179
162Broad thumb (HP:0011304)1.73696760
163Abnormality of the phalanges of the 2nd finger (HP:0009541)1.73439807
164Ventricular fibrillation (HP:0001663)1.72915247
165Scrotal hypoplasia (HP:0000046)1.72837719
166Atresia of the external auditory canal (HP:0000413)1.72687598
167Hypoplastic labia majora (HP:0000059)1.72686837
168Limited hip movement (HP:0008800)1.72580475
169Neoplasm of the colon (HP:0100273)1.72162942
170Nasolacrimal duct obstruction (HP:0000579)1.71994774
171Genital tract atresia (HP:0001827)1.71409215
172Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.70033811
173Meningocele (HP:0002435)1.69412147
174Embryonal neoplasm (HP:0002898)1.68906014
175Back pain (HP:0003418)1.68689761
176Breast aplasia (HP:0100783)1.68574118
177Abnormality of the diencephalon (HP:0010662)1.68234042
178Megaloblastic anemia (HP:0001889)1.67592257
179Microglossia (HP:0000171)1.67329225

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.98531464
2LATS13.94247835
3PKN23.93171995
4STK243.47942978
5STK38L3.14347698
6LATS23.09504310
7TNIK2.91016557
8PLK42.67804588
9MYLK2.65660023
10TAF12.55560849
11DMPK2.43270678
12BUB12.37238006
13SRPK12.32381064
14OBSCN2.29018058
15TSSK62.27640221
16NME12.24637207
17TRIB32.19161527
18VRK22.19152337
19PBK2.17564580
20STK31.91423994
21LMTK21.88730386
22PDGFRA1.88171303
23EPHB21.86476773
24WNK31.82935353
25ILK1.78195429
26MAP3K101.74694344
27TTN1.70478162
28MET1.69352373
29TRIM281.62434358
30PNCK1.48517928
31MKNK11.42385217
32OXSR11.42081457
33WEE11.39833613
34PLK11.37645664
35CDC42BPA1.33647161
36PTK61.33331301
37MST41.33283167
38PTK2B1.33078274
39CASK1.32247752
40CDK121.32092903
41BRSK21.29282186
42FGFR11.28185796
43ERBB31.24995803
44PRKD31.21408299
45CDC71.19062038
46VRK11.17496403
47RIPK11.11825776
48NUAK11.11196135
49NEK11.11055682
50CHEK21.07890040
51TGFBR11.07580822
52ACVR1B1.03798007
53PIK3CA1.02795384
54ROCK11.00747798
55FER1.00725462
56DYRK31.00474597
57TTK0.98746439
58PAK20.98142442
59PDK40.94745501
60PDK30.94745501
61STK160.94347027
62MKNK20.93935011
63TRPM70.93916879
64BRD40.92208952
65DYRK20.91124171
66BMPR1B0.89867385
67ATR0.89392639
68SIK10.88519412
69WNK40.88340328
70PDGFRB0.87402944
71EPHA40.85216208
72RET0.84869074
73ALK0.84769398
74LRRK20.84429964
75MTOR0.83672258
76PAK40.83493131
77ERBB20.82744329
78KSR10.80266167
79EEF2K0.78790511
80MUSK0.78725121
81AKT30.78303908
82PLK30.77205191
83EIF2AK30.74555241
84WNK10.73904281
85SMG10.73727161
86CDK80.73151964
87CDK60.72915811
88PLK20.72381319
89RPS6KA40.68253236
90EPHA30.68021724
91PHKG10.66198008
92PHKG20.66198008
93TLK10.66077160
94MELK0.65479585
95CDK190.65438366
96EIF2AK20.62912695
97INSRR0.62892382
98PTK20.61798659
99BMX0.61445413
100STK390.60743132
101PRKD10.59868628
102ICK0.59785233
103FGFR20.59728748
104TIE10.59121185
105PAK30.58575334
106CSNK1A1L0.58071410
107CSNK1E0.57918713
108BRAF0.57812812
109NEK20.57670171
110ROCK20.57413724
111NLK0.56240468
112CLK10.54393997
113UHMK10.54189742
114BCR0.53220970
115FLT30.52621757
116CAMK1G0.52251632
117GRK10.51399337
118DAPK30.51098784
119CDK40.50539715
120ERBB40.50052623
121MAP3K40.48739625
122STK40.48707313
123PRKCE0.47864666
124RPS6KB20.47641287
125TGFBR20.46011763
126PASK0.45099971
127AKT20.44926677
128RPS6KL10.44288325
129RPS6KC10.44288325
130PRKDC0.43986304
131CDK20.42427564
132DYRK1A0.41137562
133MAP3K70.40845985
134ATM0.40845973
135CDK70.40590495
136CSNK1G10.40319262
137CHEK10.40230931
138TYRO30.39947475
139NME20.39166443
140SCYL20.38930462
141KSR20.38082974
142MARK30.37128120
143ZAK0.36924945
144EPHA20.35457201
145CSNK2A10.35362972
146CSNK2A20.34581162
147BRSK10.34205176
148CSNK1D0.33945865
149AURKA0.31739390
150AKT10.31500571
151CDK10.30703465
152AURKB0.30538671
153MAP3K80.30241059
154MAPK10.29944177
155RPS6KA60.28941503
156PRKCG0.28551534
157ADRBK10.28299272
158MAP3K90.26653852
159CDK30.24045277

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.79705439
2Mismatch repair_Homo sapiens_hsa034303.38752676
3DNA replication_Homo sapiens_hsa030303.19833495
4Dilated cardiomyopathy_Homo sapiens_hsa054143.16685694
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.09243895
6ECM-receptor interaction_Homo sapiens_hsa045122.98150767
7Hedgehog signaling pathway_Homo sapiens_hsa043402.93110979
8Hippo signaling pathway_Homo sapiens_hsa043902.81856338
9Non-homologous end-joining_Homo sapiens_hsa034502.77318958
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.68572101
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.56526954
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.31167306
13Adherens junction_Homo sapiens_hsa045202.31012712
14Ribosome_Homo sapiens_hsa030102.30633625
15Homologous recombination_Homo sapiens_hsa034402.28384666
16Proteasome_Homo sapiens_hsa030502.25941898
17Focal adhesion_Homo sapiens_hsa045102.24320559
18Protein digestion and absorption_Homo sapiens_hsa049742.23891515
19TGF-beta signaling pathway_Homo sapiens_hsa043502.17267577
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.07450756
21Wnt signaling pathway_Homo sapiens_hsa043101.95734018
22RNA polymerase_Homo sapiens_hsa030201.93611738
23Cardiac muscle contraction_Homo sapiens_hsa042601.92979914
24Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.86550686
25Proteoglycans in cancer_Homo sapiens_hsa052051.85598771
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.81772491
27Viral myocarditis_Homo sapiens_hsa054161.81345394
28Selenocompound metabolism_Homo sapiens_hsa004501.80140602
29Fanconi anemia pathway_Homo sapiens_hsa034601.79339756
30Base excision repair_Homo sapiens_hsa034101.78270098
31Tight junction_Homo sapiens_hsa045301.72777378
32Steroid biosynthesis_Homo sapiens_hsa001001.71255254
33Nucleotide excision repair_Homo sapiens_hsa034201.69928699
34Basal transcription factors_Homo sapiens_hsa030221.67116994
35One carbon pool by folate_Homo sapiens_hsa006701.58565472
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.54055471
37Small cell lung cancer_Homo sapiens_hsa052221.52792823
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52223866
39Lysine degradation_Homo sapiens_hsa003101.51463836
40Melanogenesis_Homo sapiens_hsa049161.51186880
41Notch signaling pathway_Homo sapiens_hsa043301.44456212
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44279472
43Protein export_Homo sapiens_hsa030601.44194103
44Ovarian steroidogenesis_Homo sapiens_hsa049131.44109401
45Cell cycle_Homo sapiens_hsa041101.43637598
46Pyruvate metabolism_Homo sapiens_hsa006201.39817405
47MicroRNAs in cancer_Homo sapiens_hsa052061.39759536
48Colorectal cancer_Homo sapiens_hsa052101.35678053
49mRNA surveillance pathway_Homo sapiens_hsa030151.35191444
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32040229
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.31136755
52Vitamin digestion and absorption_Homo sapiens_hsa049771.30140966
53Endometrial cancer_Homo sapiens_hsa052131.30139473
54Pathways in cancer_Homo sapiens_hsa052001.29681325
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.27491545
56Axon guidance_Homo sapiens_hsa043601.26714124
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25623348
58Dorso-ventral axis formation_Homo sapiens_hsa043201.21509602
59Amoebiasis_Homo sapiens_hsa051461.17695893
60Thyroid hormone signaling pathway_Homo sapiens_hsa049191.16258732
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.15687781
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14843395
63Biosynthesis of amino acids_Homo sapiens_hsa012301.11620752
64Chronic myeloid leukemia_Homo sapiens_hsa052201.09737310
65Oocyte meiosis_Homo sapiens_hsa041141.09535598
66Insulin resistance_Homo sapiens_hsa049311.08265155
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04055514
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03226358
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00689148
70HTLV-I infection_Homo sapiens_hsa051661.00343714
71PI3K-Akt signaling pathway_Homo sapiens_hsa041511.00224138
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97804685
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97153876
74Thyroid cancer_Homo sapiens_hsa052160.96632553
75Vitamin B6 metabolism_Homo sapiens_hsa007500.94721551
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.93797654
77Estrogen signaling pathway_Homo sapiens_hsa049150.93717185
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93293997
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93259759
80Huntingtons disease_Homo sapiens_hsa050160.92759684
81Prostate cancer_Homo sapiens_hsa052150.92687637
82Oxidative phosphorylation_Homo sapiens_hsa001900.90854554
83Pyrimidine metabolism_Homo sapiens_hsa002400.87339031
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83799244
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83281222
86Renal cell carcinoma_Homo sapiens_hsa052110.82123007
87Purine metabolism_Homo sapiens_hsa002300.82091934
88Melanoma_Homo sapiens_hsa052180.81882595
89Parkinsons disease_Homo sapiens_hsa050120.81873745
90p53 signaling pathway_Homo sapiens_hsa041150.80788911
91mTOR signaling pathway_Homo sapiens_hsa041500.79632648
92Insulin signaling pathway_Homo sapiens_hsa049100.78450049
93Glucagon signaling pathway_Homo sapiens_hsa049220.75668998
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.72141207
95Toxoplasmosis_Homo sapiens_hsa051450.71811368
96Pancreatic cancer_Homo sapiens_hsa052120.71559523
97Rap1 signaling pathway_Homo sapiens_hsa040150.70998208
98RNA degradation_Homo sapiens_hsa030180.70434558
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.69733630
100RNA transport_Homo sapiens_hsa030130.67685264
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66089159
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65193023
103Glutathione metabolism_Homo sapiens_hsa004800.64990122
104Oxytocin signaling pathway_Homo sapiens_hsa049210.63994669
105FoxO signaling pathway_Homo sapiens_hsa040680.62285697
106Type II diabetes mellitus_Homo sapiens_hsa049300.61987704
107Glioma_Homo sapiens_hsa052140.59914329
108Fatty acid degradation_Homo sapiens_hsa000710.59788869
109cAMP signaling pathway_Homo sapiens_hsa040240.59280433
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59151724
111HIF-1 signaling pathway_Homo sapiens_hsa040660.59044029
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57508512
113Renin secretion_Homo sapiens_hsa049240.55736822
114Bladder cancer_Homo sapiens_hsa052190.50163675
115ErbB signaling pathway_Homo sapiens_hsa040120.49946167
116Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49661252
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49555931
118AMPK signaling pathway_Homo sapiens_hsa041520.49521441
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49485709
120Gap junction_Homo sapiens_hsa045400.49144082
121Spliceosome_Homo sapiens_hsa030400.48250990
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48069311
123Folate biosynthesis_Homo sapiens_hsa007900.47797351
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47567600
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.45923998
126Arginine and proline metabolism_Homo sapiens_hsa003300.45467840
127N-Glycan biosynthesis_Homo sapiens_hsa005100.45065952
128Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45042836
129Metabolic pathways_Homo sapiens_hsa011000.44495878
130Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43320625
131Alzheimers disease_Homo sapiens_hsa050100.42418298
132Fatty acid metabolism_Homo sapiens_hsa012120.41638517
133Taste transduction_Homo sapiens_hsa047420.40458767
134GnRH signaling pathway_Homo sapiens_hsa049120.40303532
135Platelet activation_Homo sapiens_hsa046110.39612712
136Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37976733
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36011294
138Calcium signaling pathway_Homo sapiens_hsa040200.35569382
139Carbon metabolism_Homo sapiens_hsa012000.35102528
140Alcoholism_Homo sapiens_hsa050340.34879098
141Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34115528
142Viral carcinogenesis_Homo sapiens_hsa052030.32249046
143beta-Alanine metabolism_Homo sapiens_hsa004100.31487276
144Propanoate metabolism_Homo sapiens_hsa006400.30953427
145Phototransduction_Homo sapiens_hsa047440.30554470
146Fatty acid elongation_Homo sapiens_hsa000620.30156276
147Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29838157
148Ether lipid metabolism_Homo sapiens_hsa005650.29307077
149Prolactin signaling pathway_Homo sapiens_hsa049170.28985806
150Non-small cell lung cancer_Homo sapiens_hsa052230.28865569
151MAPK signaling pathway_Homo sapiens_hsa040100.27625132
152VEGF signaling pathway_Homo sapiens_hsa043700.26392389
153Circadian entrainment_Homo sapiens_hsa047130.26155118
154Gastric acid secretion_Homo sapiens_hsa049710.26046691
155Long-term depression_Homo sapiens_hsa047300.24642449
156Fat digestion and absorption_Homo sapiens_hsa049750.23374781
157Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22551894
158alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22365269

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