ADAMTS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease, a member of the procollagen aminopropeptidase subfamily of proteins, may play a role in the processing of type II fibrillar collagen in articular cartilage. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.48618284
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.45760212
3locomotory exploration behavior (GO:0035641)5.29251415
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.17979772
5synaptic vesicle maturation (GO:0016188)5.02894409
6neuronal action potential propagation (GO:0019227)4.92535091
7presynaptic membrane assembly (GO:0097105)4.87634388
8dendritic spine morphogenesis (GO:0060997)4.72916508
9membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.70123054
10regulation of long-term neuronal synaptic plasticity (GO:0048169)4.68722649
11regulation of synapse structural plasticity (GO:0051823)4.59821011
12vocalization behavior (GO:0071625)4.50951522
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.48485919
14synaptic transmission, glutamatergic (GO:0035249)4.44935927
15protein localization to synapse (GO:0035418)4.36299896
16regulation of glutamate receptor signaling pathway (GO:1900449)4.35887682
17regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.29187721
18positive regulation of male gonad development (GO:2000020)4.28397472
19neuronal ion channel clustering (GO:0045161)4.28028671
20synaptic vesicle docking involved in exocytosis (GO:0016081)4.27587988
21regulation of neuronal synaptic plasticity (GO:0048168)4.26611868
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.19143776
23neuron-neuron synaptic transmission (GO:0007270)4.12865926
24presynaptic membrane organization (GO:0097090)4.09711518
25negative regulation of cytosolic calcium ion concentration (GO:0051481)4.07486449
26synaptic vesicle exocytosis (GO:0016079)4.04722973
27axonal fasciculation (GO:0007413)4.00492546
28prepulse inhibition (GO:0060134)4.00156663
29neurotransmitter-gated ion channel clustering (GO:0072578)3.89178935
30exploration behavior (GO:0035640)3.87006702
31otic vesicle formation (GO:0030916)3.86432592
32regulation of synaptic vesicle exocytosis (GO:2000300)3.74968973
33mitotic sister chromatid cohesion (GO:0007064)3.74498471
34glutamate receptor signaling pathway (GO:0007215)3.69754523
35positive regulation of neurotransmitter transport (GO:0051590)3.66624350
36synaptic transmission, dopaminergic (GO:0001963)3.65398820
37long-term memory (GO:0007616)3.64456300
38layer formation in cerebral cortex (GO:0021819)3.63079362
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.61161449
40limb bud formation (GO:0060174)3.59621154
41striatum development (GO:0021756)3.58184317
42glutamate secretion (GO:0014047)3.56840867
43regulation of male gonad development (GO:2000018)3.53373869
44dopamine receptor signaling pathway (GO:0007212)3.52101437
45neurotransmitter secretion (GO:0007269)3.50620358
46regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.50160637
47replication fork processing (GO:0031297)3.49562014
48positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.49307401
49innervation (GO:0060384)3.48870360
50neuron recognition (GO:0008038)3.48819973
51auditory behavior (GO:0031223)3.47395355
52positive regulation of membrane potential (GO:0045838)3.46606379
53regulation of synaptic vesicle transport (GO:1902803)3.45910669
54regulation of postsynaptic membrane potential (GO:0060078)3.45130226
55regulation of dendritic spine morphogenesis (GO:0061001)3.44155081
56resolution of meiotic recombination intermediates (GO:0000712)3.43288309
57regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.43001376
58protein localization to kinetochore (GO:0034501)3.42898541
59positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.42527216
60positive regulation of neurotransmitter secretion (GO:0001956)3.40587964
61behavioral defense response (GO:0002209)3.34841194
62behavioral fear response (GO:0001662)3.34841194
63nuclear pore complex assembly (GO:0051292)3.30986764
64positive regulation of synaptic transmission, GABAergic (GO:0032230)3.30422132
65G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.29545841
66lateral sprouting from an epithelium (GO:0060601)3.28987718
67regulation of penile erection (GO:0060405)3.28666721
68CENP-A containing nucleosome assembly (GO:0034080)3.28322996
69neuromuscular process controlling balance (GO:0050885)3.26298385
70negative regulation of vascular permeability (GO:0043116)3.26152099
71kinetochore organization (GO:0051383)3.25538758
72dendritic spine organization (GO:0097061)3.24978668
73neuron cell-cell adhesion (GO:0007158)3.24054185
74membrane hyperpolarization (GO:0060081)3.23459639
75regulation of synaptic plasticity (GO:0048167)3.23153103
76regulation of voltage-gated calcium channel activity (GO:1901385)3.21819191
77adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.21175310
78membrane depolarization during action potential (GO:0086010)3.19511509
79chromatin remodeling at centromere (GO:0031055)3.18833369
80regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.18156388
81regulation of synaptic transmission, glutamatergic (GO:0051966)3.17825812
82negative regulation of dendrite development (GO:2000171)3.16456130
83sister chromatid segregation (GO:0000819)3.13389274
84postsynaptic membrane organization (GO:0001941)3.13188522
85mitotic chromosome condensation (GO:0007076)3.12737811
86cAMP catabolic process (GO:0006198)3.12297770
87response to auditory stimulus (GO:0010996)3.09907984
88retinal ganglion cell axon guidance (GO:0031290)3.06943738
89negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05943904
90cellular potassium ion homeostasis (GO:0030007)3.04726107
91DNA double-strand break processing (GO:0000729)3.02010434
92cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.01241081
93DNA topological change (GO:0006265)2.99941669
94metaphase plate congression (GO:0051310)2.98734623
95visual learning (GO:0008542)2.98444106
96central nervous system projection neuron axonogenesis (GO:0021952)2.97436486
97behavioral response to cocaine (GO:0048148)2.96737104
98membrane depolarization (GO:0051899)2.96652957
99cell communication by electrical coupling (GO:0010644)2.96649877
100fear response (GO:0042596)2.95940328
101mitotic metaphase plate congression (GO:0007080)2.95012051
102G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.94834411
103sodium ion export (GO:0071436)2.94678278
104chondrocyte development (GO:0002063)2.94481509
105regulation of rhodopsin mediated signaling pathway (GO:0022400)2.94394256
106activation of protein kinase A activity (GO:0034199)2.94226346
107response to amphetamine (GO:0001975)2.94102774
108positive regulation of synapse maturation (GO:0090129)2.93814503
109nuclear pore organization (GO:0006999)2.93781764
110regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.93514976
111regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.93514976
112gamma-aminobutyric acid transport (GO:0015812)2.91987630
113DNA replication checkpoint (GO:0000076)2.89344906
114dendrite morphogenesis (GO:0048813)2.88803199
115notochord development (GO:0030903)2.88733343
116axon extension involved in axon guidance (GO:0048846)2.88468441
117neuron projection extension involved in neuron projection guidance (GO:1902284)2.88468441
118regulation of clathrin-mediated endocytosis (GO:2000369)2.88454810
119chemosensory behavior (GO:0007635)2.87340478
120maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.85923251
121learning (GO:0007612)2.85774938
122protein localization to chromosome, centromeric region (GO:0071459)2.84798407
123rhodopsin mediated signaling pathway (GO:0016056)2.84028363
124histone exchange (GO:0043486)2.83640657
125response to histamine (GO:0034776)2.82967324
126regulation of neurotransmitter secretion (GO:0046928)2.82133761
127negative regulation of axon extension involved in axon guidance (GO:0048843)2.81741313
128transmission of nerve impulse (GO:0019226)2.81643191
129DNA replication-independent nucleosome assembly (GO:0006336)2.81311620
130DNA replication-independent nucleosome organization (GO:0034724)2.81311620
131mitotic sister chromatid segregation (GO:0000070)2.80768574
132mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.80174603
133establishment of nucleus localization (GO:0040023)2.79657232
134regulation of female receptivity (GO:0045924)2.78099859
135ganglion development (GO:0061548)2.77859657
136cell communication involved in cardiac conduction (GO:0086065)2.77445824
137visual behavior (GO:0007632)2.77114227
138hindbrain development (GO:0030902)2.76993477
139negative chemotaxis (GO:0050919)2.76515630
140C4-dicarboxylate transport (GO:0015740)2.75316985
141proximal/distal pattern formation (GO:0009954)2.74059599
142negative regulation of axon guidance (GO:1902668)2.70665263
143DNA replication-dependent nucleosome assembly (GO:0006335)2.70345158
144DNA replication-dependent nucleosome organization (GO:0034723)2.70345158
145L-serine metabolic process (GO:0006563)2.66227187
146protein localization to chromosome (GO:0034502)2.63239692
147regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.59118443
148regulation of mitotic metaphase/anaphase transition (GO:0030071)2.59118443
149kinetochore assembly (GO:0051382)2.58738969
150paraxial mesoderm development (GO:0048339)2.58493711
151spindle checkpoint (GO:0031577)2.58089756
152DNA unwinding involved in DNA replication (GO:0006268)2.57235563
153negative regulation of protein localization to cell surface (GO:2000009)2.55786476
154mesenchymal-epithelial cell signaling (GO:0060638)2.53050165
155centriole replication (GO:0007099)2.52462132
156negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.51481658
157negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.51481658
158negative regulation of mitotic sister chromatid segregation (GO:0033048)2.51481658
159negative regulation of mitotic sister chromatid separation (GO:2000816)2.51481658
160negative regulation of sister chromatid segregation (GO:0033046)2.51481658
161regulation of DNA endoreduplication (GO:0032875)2.51082527
162axis elongation (GO:0003401)2.49366506
163outer ear morphogenesis (GO:0042473)2.47997316
164negative regulation of chromosome segregation (GO:0051985)2.47729233
165negative regulation of DNA recombination (GO:0045910)2.46251717
166negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.45400591
167lens fiber cell development (GO:0070307)2.44693975
168mitotic cytokinesis (GO:0000281)2.42090969
169branch elongation of an epithelium (GO:0060602)2.41698570
170spindle assembly checkpoint (GO:0071173)2.41544961
171mitotic spindle checkpoint (GO:0071174)2.40754727
172mitotic spindle assembly checkpoint (GO:0007094)2.40413642
173regulation of centriole replication (GO:0046599)2.40403519
174regulation of sister chromatid segregation (GO:0033045)2.40066668
175regulation of mitotic sister chromatid separation (GO:0010965)2.40066668
176regulation of mitotic sister chromatid segregation (GO:0033047)2.40066668
177cellular response to cholesterol (GO:0071397)2.40033285
178retina vasculature morphogenesis in camera-type eye (GO:0061299)2.38629462
179establishment of chromosome localization (GO:0051303)2.36076422
180cholesterol biosynthetic process (GO:0006695)2.35952927
181meiotic chromosome segregation (GO:0045132)2.33907904
182mitotic nuclear envelope disassembly (GO:0007077)2.33081562
183negative regulation of mitosis (GO:0045839)2.33024796
184regulation of chromosome segregation (GO:0051983)2.32958847
185developmental induction (GO:0031128)2.31970856
186olfactory bulb development (GO:0021772)2.31454178
187positive regulation of chondrocyte differentiation (GO:0032332)2.29901897
188dorsal/ventral axis specification (GO:0009950)2.29356622
189cell-cell signaling involved in cell fate commitment (GO:0045168)2.27825275
190mechanosensory behavior (GO:0007638)2.25651801
191microtubule depolymerization (GO:0007019)2.25599125
192retinal rod cell development (GO:0046548)2.24337236
193appendage development (GO:0048736)2.24159459
194limb development (GO:0060173)2.24159459

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.21379058
2E2F7_22180533_ChIP-Seq_HELA_Human5.15843686
3GBX2_23144817_ChIP-Seq_PC3_Human3.62629416
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.42006262
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.11764606
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.03005779
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98734988
8DROSHA_22980978_ChIP-Seq_HELA_Human2.95371147
9* RARB_27405468_Chip-Seq_BRAIN_Mouse2.84878039
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.84378808
11* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.84378808
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.72143213
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.64188806
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.60451628
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58302596
16* EZH2_27304074_Chip-Seq_ESCs_Mouse2.56435792
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.55132106
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47839023
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44554145
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42631067
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.40517560
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.37398838
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.35074430
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.34853164
25FUS_26573619_Chip-Seq_HEK293_Human2.30932843
26AR_21909140_ChIP-Seq_LNCAP_Human2.25954229
27REST_21632747_ChIP-Seq_MESCs_Mouse2.23904059
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.23071658
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.19368300
30* EWS_26573619_Chip-Seq_HEK293_Human2.19035071
31AR_21572438_ChIP-Seq_LNCaP_Human2.17097383
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.15208711
33SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14357938
34EZH2_27294783_Chip-Seq_ESCs_Mouse2.11901663
35KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.04761798
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.96051624
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.93954315
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91884769
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.91191109
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86034946
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.83403094
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.81519202
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.74522175
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73268515
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72038804
46* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66230828
47HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.65131976
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.59756017
49ELK1_19687146_ChIP-ChIP_HELA_Human1.58589992
50* SMAD4_21799915_ChIP-Seq_A2780_Human1.55305323
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.55301104
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.54586817
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53291474
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52163139
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51929413
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44670206
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.44493788
58SOX9_26525672_Chip-Seq_HEART_Mouse1.44014547
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43308809
60AR_19668381_ChIP-Seq_PC3_Human1.40211619
61* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39634328
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.37881881
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.37341708
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.37279890
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37184852
66VDR_22108803_ChIP-Seq_LS180_Human1.36684066
67KDM2B_26808549_Chip-Seq_K562_Human1.34735073
68TAF15_26573619_Chip-Seq_HEK293_Human1.32133174
69* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.31813746
70KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.31713988
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31007559
72ESR1_20079471_ChIP-ChIP_T-47D_Human1.30609964
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30193292
74KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.29494950
75STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.27245797
76E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26649265
77* STAT3_23295773_ChIP-Seq_U87_Human1.25624907
78RING1B_27294783_Chip-Seq_NPCs_Mouse1.25068196
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.24609596
80TP53_18474530_ChIP-ChIP_U2OS_Human1.23528068
81TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23369823
82TBX3_20139965_ChIP-Seq_ESCs_Mouse1.22857835
83TBX3_20139965_ChIP-Seq_MESCs_Mouse1.22489766
84RNF2_27304074_Chip-Seq_NSC_Mouse1.21641162
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20003789
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20003789
87* P300_19829295_ChIP-Seq_ESCs_Human1.19590073
88CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19586529
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18757141
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18302737
91E2F1_21310950_ChIP-Seq_MCF-7_Human1.18028311
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.16910544
93VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16776432
94TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.15939556
95JUN_21703547_ChIP-Seq_K562_Human1.15610301
96P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15253528
97ZNF274_21170338_ChIP-Seq_K562_Hela1.15013862
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14512470
99* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14343217
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14100931
101ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12646512
102LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12483649
103NANOG_16153702_ChIP-ChIP_HESCs_Human1.12470935
104* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12168597
105DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11561923
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11297365
107NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11294496
108EP300_21415370_ChIP-Seq_HL-1_Mouse1.11287051
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09990976
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09564827
111SMAD3_21741376_ChIP-Seq_HESCs_Human1.09474308
112SOX2_16153702_ChIP-ChIP_HESCs_Human1.07713727
113EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07582054
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07432846
115CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07355549
116DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07112364
117AHR_22903824_ChIP-Seq_MCF-7_Human1.06626894
118ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05972118
119NANOG_18555785_Chip-Seq_ESCs_Mouse1.05858206
120* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05818761
121GATA1_26923725_Chip-Seq_HPCs_Mouse1.05586126
122* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05439194
123* TP53_16413492_ChIP-PET_HCT116_Human1.05109992
124PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04020390
125PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03589069
126AR_25329375_ChIP-Seq_VCAP_Human1.03587882
127NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03348797
128NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03348797
129SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03291978
130RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03253984
131GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02805542
132* TCF4_23295773_ChIP-Seq_U87_Human1.02757167
133CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02636966
134GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01958596
135NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01423867
136RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01008395
137ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00716993
138PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00412096
139OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00369857
140FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.00050826
141ER_23166858_ChIP-Seq_MCF-7_Human0.99624358
142SMAD3_21741376_ChIP-Seq_ESCs_Human0.99329481
143* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98675516
144MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98642141
145* PIAS1_25552417_ChIP-Seq_VCAP_Human0.98591393
146PRDM14_20953172_ChIP-Seq_ESCs_Human0.98447234
147IGF1R_20145208_ChIP-Seq_DFB_Human0.97689682
148NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96552772
149PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96437097
150* RUNX2_22187159_ChIP-Seq_PCA_Human0.96288784
151SMAD4_21741376_ChIP-Seq_HESCs_Human0.95882995
152POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.95060942
153SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94457743
154YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93683890
155* CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91209794
156TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90171827
157SMAD_19615063_ChIP-ChIP_OVARY_Human0.89357484
158CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87199345
159CTCF_27219007_Chip-Seq_Bcells_Human0.86811638

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.50133057
2MP0002822_catalepsy4.80914394
3MP0003880_abnormal_central_pattern4.02399680
4MP0003635_abnormal_synaptic_transmissio3.89532048
5MP0003136_yellow_coat_color3.28369353
6MP0004270_analgesia3.21339159
7MP0002063_abnormal_learning/memory/cond3.10918626
8MP0009745_abnormal_behavioral_response2.96516406
9MP0005423_abnormal_somatic_nervous2.70829023
10MP0002064_seizures2.45297082
11MP0005171_absent_coat_pigmentation2.44663256
12MP0002572_abnormal_emotion/affect_behav2.37039361
13MP0001968_abnormal_touch/_nociception2.30949139
14MP0005551_abnormal_eye_electrophysiolog2.30357473
15MP0001486_abnormal_startle_reflex2.29681562
16MP0003937_abnormal_limbs/digits/tail_de2.26476108
17MP0009046_muscle_twitch2.23347854
18MP0002272_abnormal_nervous_system2.19291100
19MP0003941_abnormal_skin_development2.14743675
20MP0000566_synostosis2.09854103
21MP0002734_abnormal_mechanical_nocicepti2.05956188
22MP0002735_abnormal_chemical_nociception1.93564519
23MP0010094_abnormal_chromosome_stability1.92086772
24MP0002909_abnormal_adrenal_gland1.82719225
25MP0003385_abnormal_body_wall1.81037924
26MP0009780_abnormal_chondrocyte_physiolo1.79726000
27MP0008058_abnormal_DNA_repair1.79573747
28MP0008569_lethality_at_weaning1.78387279
29MP0002184_abnormal_innervation1.77302429
30MP0003755_abnormal_palate_morphology1.73559201
31MP0001188_hyperpigmentation1.72620390
32MP0000778_abnormal_nervous_system1.70736701
33MP0004957_abnormal_blastocyst_morpholog1.70718258
34MP0000428_abnormal_craniofacial_morphol1.69944719
35MP0000516_abnormal_urinary_system1.69389502
36MP0005367_renal/urinary_system_phenotyp1.69389502
37MP0010030_abnormal_orbit_morphology1.68606333
38MP0005386_behavior/neurological_phenoty1.67180655
39MP0004924_abnormal_behavior1.67180655
40MP0003890_abnormal_embryonic-extraembry1.66734102
41MP0008932_abnormal_embryonic_tissue1.65445800
42MP0002233_abnormal_nose_morphology1.64555120
43MP0009250_abnormal_appendicular_skeleto1.62931992
44MP0000751_myopathy1.61788786
45MP0004272_abnormal_basement_membrane1.61415209
46MP0001529_abnormal_vocalization1.61169963
47MP0005646_abnormal_pituitary_gland1.57277171
48MP0004811_abnormal_neuron_physiology1.56815758
49MP0000049_abnormal_middle_ear1.51702145
50MP0000955_abnormal_spinal_cord1.50908545
51MP0009697_abnormal_copulation1.50693731
52MP0002736_abnormal_nociception_after1.49326020
53MP0002067_abnormal_sensory_capabilities1.48763299
54MP0009053_abnormal_anal_canal1.47770465
55MP0001293_anophthalmia1.46853860
56MP0005248_abnormal_Harderian_gland1.46109608
57MP0003111_abnormal_nucleus_morphology1.45669858
58MP0006072_abnormal_retinal_apoptosis1.44492632
59MP0002882_abnormal_neuron_morphology1.44415964
60MP0001970_abnormal_pain_threshold1.43802531
61MP0004233_abnormal_muscle_weight1.41719304
62MP0003935_abnormal_craniofacial_develop1.41296874
63MP0001286_abnormal_eye_development1.40875158
64MP0002557_abnormal_social/conspecific_i1.40110147
65MP0001299_abnormal_eye_distance/1.39949435
66MP0004215_abnormal_myocardial_fiber1.39550650
67MP0001501_abnormal_sleep_pattern1.38766546
68MP0002733_abnormal_thermal_nociception1.37890601
69MP0002938_white_spotting1.37419942
70MP0003718_maternal_effect1.37154482
71MP0004885_abnormal_endolymph1.36302335
72MP0003646_muscle_fatigue1.33832677
73MP0003137_abnormal_impulse_conducting1.30079276
74MP0002084_abnormal_developmental_patter1.28846042
75MP0003077_abnormal_cell_cycle1.28201769
76MP0002697_abnormal_eye_size1.28065247
77MP0002653_abnormal_ependyma_morphology1.27670257
78MP0000462_abnormal_digestive_system1.27606729
79MP0003119_abnormal_digestive_system1.27461649
80MP0005253_abnormal_eye_physiology1.25619998
81MP0004085_abnormal_heartbeat1.25579325
82MP0004858_abnormal_nervous_system1.23891561
83MP0008789_abnormal_olfactory_epithelium1.21421344
84MP0000579_abnormal_nail_morphology1.20875035
85MP0000569_abnormal_digit_pigmentation1.20102116
86MP0003283_abnormal_digestive_organ1.19748772
87MP0002111_abnormal_tail_morphology1.19280845
88MP0003879_abnormal_hair_cell1.18512366
89MP0001440_abnormal_grooming_behavior1.17065899
90MP0000647_abnormal_sebaceous_gland1.16018873
91MP0002066_abnormal_motor_capabilities/c1.15888836
92MP0003315_abnormal_perineum_morphology1.15866670
93MP0002085_abnormal_embryonic_tissue1.15696876
94MP0004084_abnormal_cardiac_muscle1.14170758
95MP0004145_abnormal_muscle_electrophysio1.13953649
96MP0003122_maternal_imprinting1.10646750
97MP0002090_abnormal_vision1.10549187
98MP0005623_abnormal_meninges_morphology1.07741868
99MP0000762_abnormal_tongue_morphology1.07425898
100MP0002249_abnormal_larynx_morphology1.07269404
101MP0006292_abnormal_olfactory_placode1.06618412
102MP0002638_abnormal_pupillary_reflex1.06049806
103MP0002751_abnormal_autonomic_nervous1.04623392
104MP0005380_embryogenesis_phenotype1.04608183
105MP0001672_abnormal_embryogenesis/_devel1.04608183
106MP0002152_abnormal_brain_morphology1.03677457
107MP0000749_muscle_degeneration1.02400571
108MP0004142_abnormal_muscle_tone1.02126814
109MP0008057_abnormal_DNA_replication1.02037022
110MP0001177_atelectasis0.99390680
111MP0000534_abnormal_ureter_morphology0.99211521
112MP0000631_abnormal_neuroendocrine_gland0.98724725
113MP0000432_abnormal_head_morphology0.98184357
114MP0003121_genomic_imprinting0.97915526
115MP0002229_neurodegeneration0.97330965
116MP0003567_abnormal_fetal_cardiomyocyte0.97151312
117MP0004742_abnormal_vestibular_system0.97035290
118MP0001697_abnormal_embryo_size0.94887174
119MP0001984_abnormal_olfaction0.94716155
120MP0003693_abnormal_embryo_hatching0.94094875
121MP0003984_embryonic_growth_retardation0.93968287
122MP0008872_abnormal_physiological_respon0.92771392
123MP0001502_abnormal_circadian_rhythm0.92362060
124MP0010307_abnormal_tumor_latency0.91913342
125MP0002088_abnormal_embryonic_growth/wei0.91644239
126MP0009703_decreased_birth_body0.90771398
127MP0003011_delayed_dark_adaptation0.89818110
128MP0002752_abnormal_somatic_nervous0.89564383
129MP0008438_abnormal_cutaneous_collagen0.89440763
130MP0003787_abnormal_imprinting0.88209813
131MP0008961_abnormal_basal_metabolism0.88033521
132MP0003115_abnormal_respiratory_system0.87847462
133MP0002089_abnormal_postnatal_growth/wei0.86699796
134MP0002837_dystrophic_cardiac_calcinosis0.86557464
135MP0004484_altered_response_of0.86531313
136MP0002092_abnormal_eye_morphology0.86191385
137MP0002116_abnormal_craniofacial_bone0.85267990
138MP0005076_abnormal_cell_differentiation0.84827510
139MP0005503_abnormal_tendon_morphology0.83692460
140MP0003633_abnormal_nervous_system0.82936388
141MP0009384_cardiac_valve_regurgitation0.81965474
142MP0010368_abnormal_lymphatic_system0.81143981
143MP0008775_abnormal_heart_ventricle0.80683099
144MP0002095_abnormal_skin_pigmentation0.79856904
145MP0003329_amyloid_beta_deposits0.79549163
146MP0005174_abnormal_tail_pigmentation0.79064082
147MP0004197_abnormal_fetal_growth/weight/0.78889239
148MP0003942_abnormal_urinary_system0.78389673
149MP0004036_abnormal_muscle_relaxation0.77878283
150MP0002109_abnormal_limb_morphology0.77318098
151MP0008874_decreased_physiological_sensi0.76730300
152MP0002081_perinatal_lethality0.76223030
153MP0005620_abnormal_muscle_contractility0.74940569
154MP0002102_abnormal_ear_morphology0.74690594
155MP0000383_abnormal_hair_follicle0.74339214
156MP0005409_darkened_coat_color0.73992878
157MP0003634_abnormal_glial_cell0.73504875
158MP0003075_altered_response_to0.73363759
159MP0005394_taste/olfaction_phenotype0.73127157
160MP0005499_abnormal_olfactory_system0.73127157
161MP0000537_abnormal_urethra_morphology0.71215098
162MP0005195_abnormal_posterior_eye0.71000981
163MP0003861_abnormal_nervous_system0.70833344
164MP0002234_abnormal_pharynx_morphology0.68974240
165MP0005187_abnormal_penis_morphology0.65127062
166MP0002282_abnormal_trachea_morphology0.63326412
167MP0003631_nervous_system_phenotype0.63278106
168MP0004134_abnormal_chest_morphology0.62905625
169MP0004133_heterotaxia0.62591605
170MP0001963_abnormal_hearing_physiology0.62452754

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.75678281
2Focal motor seizures (HP:0011153)4.82583706
3Epiphyseal dysplasia (HP:0002656)4.35503564
4Focal seizures (HP:0007359)4.12903501
5Congenital stationary night blindness (HP:0007642)3.71296915
6Central scotoma (HP:0000603)3.67835176
7Small epiphyses (HP:0010585)3.54026734
8Vitreoretinal degeneration (HP:0000655)3.29847592
9Bony spicule pigmentary retinopathy (HP:0007737)3.22290708
10Epileptic encephalopathy (HP:0200134)3.20127889
11Papilledema (HP:0001085)3.11872411
12Ankyloglossia (HP:0010296)3.07671571
13Broad-based gait (HP:0002136)3.02196701
14Coronal craniosynostosis (HP:0004440)2.99932613
15Split foot (HP:0001839)2.97151251
16Scotoma (HP:0000575)2.96741595
17Action tremor (HP:0002345)2.96295725
18Visual hallucinations (HP:0002367)2.88185788
19Cortical dysplasia (HP:0002539)2.85351630
20Mild short stature (HP:0003502)2.84852141
21Progressive cerebellar ataxia (HP:0002073)2.81846230
22Abnormal lung lobation (HP:0002101)2.81654429
23Abnormality of macular pigmentation (HP:0008002)2.77923744
24Aplasia/Hypoplasia of the sternum (HP:0006714)2.72490582
25Poor eye contact (HP:0000817)2.69606273
26Torticollis (HP:0000473)2.69095953
27Partial duplication of thumb phalanx (HP:0009944)2.68272982
28Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.68106474
29Dyschromatopsia (HP:0007641)2.67047810
30Irregular epiphyses (HP:0010582)2.65515922
31Dysdiadochokinesis (HP:0002075)2.65010535
32Aplasia of the phalanges of the hand (HP:0009802)2.60350665
33Aplasia involving bones of the extremities (HP:0009825)2.60350665
34Aplasia involving bones of the upper limbs (HP:0009823)2.60350665
35Febrile seizures (HP:0002373)2.60108255
36Pointed chin (HP:0000307)2.56732722
37Neoplasm of the oral cavity (HP:0100649)2.54479405
38Gaze-evoked nystagmus (HP:0000640)2.51267125
39Increased nuchal translucency (HP:0010880)2.50535934
40Medulloblastoma (HP:0002885)2.49993938
41Hypoplastic ischia (HP:0003175)2.48711753
42True hermaphroditism (HP:0010459)2.47683667
43Abnormal social behavior (HP:0012433)2.47386823
44Impaired social interactions (HP:0000735)2.47386823
45Abnormal rod and cone electroretinograms (HP:0008323)2.43891864
46Scanning speech (HP:0002168)2.41235487
47Spinal muscular atrophy (HP:0007269)2.38896157
48Impaired vibration sensation in the lower limbs (HP:0002166)2.38487626
49Partial duplication of the phalanx of hand (HP:0009999)2.37116448
50Cutaneous finger syndactyly (HP:0010554)2.37032578
51Dysmetric saccades (HP:0000641)2.35675559
52Preaxial foot polydactyly (HP:0001841)2.34771879
53Bifid scrotum (HP:0000048)2.32048685
54Genetic anticipation (HP:0003743)2.31607230
55Ankle clonus (HP:0011448)2.31427814
56Esophageal atresia (HP:0002032)2.31405866
57Depression (HP:0000716)2.30486545
58Stereotypic behavior (HP:0000733)2.30362708
59Abnormal EKG (HP:0003115)2.29268707
60Duplication of thumb phalanx (HP:0009942)2.29100807
61Annular pancreas (HP:0001734)2.27884804
62Flat capital femoral epiphysis (HP:0003370)2.26900099
63Colon cancer (HP:0003003)2.25813465
64Gastrointestinal atresia (HP:0002589)2.25702453
65Volvulus (HP:0002580)2.25700804
66Truncal ataxia (HP:0002078)2.25460364
67Absent rod-and cone-mediated responses on ERG (HP:0007688)2.25104794
68Focal dystonia (HP:0004373)2.25019102
69Abnormality of the middle phalanges of the toes (HP:0010183)2.23672125
70Chromosomal breakage induced by crosslinking agents (HP:0003221)2.21978304
71Abnormality of the astrocytes (HP:0100707)2.21268378
72Astrocytoma (HP:0009592)2.21268378
73Flattened epiphyses (HP:0003071)2.19471431
74Aplasia/Hypoplasia of the tibia (HP:0005772)2.16439608
75Septo-optic dysplasia (HP:0100842)2.15559468
76Absent frontal sinuses (HP:0002688)2.14286927
77Short tibia (HP:0005736)2.14141456
78Urinary bladder sphincter dysfunction (HP:0002839)2.13965130
79Chromsome breakage (HP:0040012)2.13654433
80Diaphragmatic weakness (HP:0009113)2.12893371
81Urinary urgency (HP:0000012)2.12616410
82Intestinal atresia (HP:0011100)2.12179263
83Craniofacial dystonia (HP:0012179)2.11897304
84Absence seizures (HP:0002121)2.11657964
85Papillary thyroid carcinoma (HP:0002895)2.11354732
86Abnormality of the ischium (HP:0003174)2.09755223
87Glioma (HP:0009733)2.07458171
88Renal hypoplasia (HP:0000089)2.06594373
89Hemiparesis (HP:0001269)2.06279596
90Aplasia/Hypoplasia of the uvula (HP:0010293)2.05704908
91Primary atrial arrhythmia (HP:0001692)2.04658452
92Abnormality of the lower motor neuron (HP:0002366)2.04653722
93Cutaneous syndactyly (HP:0012725)2.04374297
94Obstructive sleep apnea (HP:0002870)2.03910346
95Meckel diverticulum (HP:0002245)2.03209582
96Lower limb amyotrophy (HP:0007210)2.03026097
97Prolonged QT interval (HP:0001657)2.02740746
98Impaired smooth pursuit (HP:0007772)2.02631135
99Abnormality of oral frenula (HP:0000190)2.02250068
100Alacrima (HP:0000522)2.02096927
101Anxiety (HP:0000739)2.02026286
102Generalized tonic-clonic seizures (HP:0002069)2.01988689
103Insomnia (HP:0100785)2.01946539
104Obsessive-compulsive behavior (HP:0000722)2.01325699
105Oligodactyly (hands) (HP:0001180)2.01164987
106Abnormality of chromosome stability (HP:0003220)2.00425147
107Absent radius (HP:0003974)1.98621459
108Dysmetria (HP:0001310)1.97077636
109Pancreatic fibrosis (HP:0100732)1.96090279
110Bifid tongue (HP:0010297)1.95921847
111Hammertoe (HP:0001765)1.95359629
112Hepatoblastoma (HP:0002884)1.95036699
113Genital tract atresia (HP:0001827)1.95008327
114Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.94838862
115Supraventricular tachycardia (HP:0004755)1.93645798
116Fibular hypoplasia (HP:0003038)1.93377467
117Abnormal tarsal ossification (HP:0008369)1.93365145
118Abnormality of the duodenum (HP:0002246)1.92252359
119Absent forearm bone (HP:0003953)1.92141871
120Aplasia involving forearm bones (HP:0009822)1.92141871
121Neonatal short-limb short stature (HP:0008921)1.91255246
122Small intestinal stenosis (HP:0012848)1.90529256
123Duodenal stenosis (HP:0100867)1.90529256
124Anophthalmia (HP:0000528)1.89731543
125Abnormality of the ileum (HP:0001549)1.88941770
126Optic nerve hypoplasia (HP:0000609)1.88931368
127Vaginal atresia (HP:0000148)1.88857338
128Drooling (HP:0002307)1.87486957
129Excessive salivation (HP:0003781)1.87486957
130Hip contracture (HP:0003273)1.87237263
131Limited hip movement (HP:0008800)1.86338120
132Supraventricular arrhythmia (HP:0005115)1.86319595
133Abnormality of the phalanges of the 2nd finger (HP:0009541)1.86047656
134Decreased lacrimation (HP:0000633)1.85816392
135Broad metatarsal (HP:0001783)1.85671159
136Abnormality of the antihelix (HP:0009738)1.85465345
137Megalencephaly (HP:0001355)1.85224695
138Dialeptic seizures (HP:0011146)1.85102510
139Short 4th metacarpal (HP:0010044)1.83867497
140Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.83867497
141Relative macrocephaly (HP:0004482)1.83439650
142Birth length less than 3rd percentile (HP:0003561)1.83006186
143Shallow orbits (HP:0000586)1.81765004
144Myelomeningocele (HP:0002475)1.81606854
145Triphalangeal thumb (HP:0001199)1.81336345
146Abnormal umbilical cord blood vessels (HP:0011403)1.80212833
147Single umbilical artery (HP:0001195)1.80212833
148Abnormality of the fetal cardiovascular system (HP:0010948)1.80212833
149Absent septum pellucidum (HP:0001331)1.79682302
150Gonadotropin excess (HP:0000837)1.79158740
151Mutism (HP:0002300)1.77960448
152Facial hemangioma (HP:0000329)1.77891837
153Chorioretinal atrophy (HP:0000533)1.77778099
154Hypoplastic labia majora (HP:0000059)1.76444336
155Abnormal sex determination (HP:0012244)1.75954128
156Sex reversal (HP:0012245)1.75954128
157Ulnar bowing (HP:0003031)1.75735444
158Pigmentary retinal degeneration (HP:0001146)1.74981645
159Atrial fibrillation (HP:0005110)1.74806727
160Pendular nystagmus (HP:0012043)1.74488739
161Impaired vibratory sensation (HP:0002495)1.74125014
162Decreased central vision (HP:0007663)1.74079623
163Abnormality of the pubic bones (HP:0003172)1.73405860
164Postural instability (HP:0002172)1.71162388
165Missing ribs (HP:0000921)1.70935066
166Abnormality of ocular smooth pursuit (HP:0000617)1.70807033
167Spinal canal stenosis (HP:0003416)1.70347522
168Type II diabetes mellitus (HP:0005978)1.69199771
169Aqueductal stenosis (HP:0002410)1.68921139
170Atonic seizures (HP:0010819)1.68914446
171Ventricular fibrillation (HP:0001663)1.68122404
172Abnormality of the labia minora (HP:0012880)1.67937292
173Hyperacusis (HP:0010780)1.67785572
174Lower limb asymmetry (HP:0100559)1.67509446
175Irregular vertebral endplates (HP:0003301)1.66803959
176Preaxial hand polydactyly (HP:0001177)1.66603072
177Abnormality of the carotid arteries (HP:0005344)1.62489335
178Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.62239907
179Abnormality of the 4th metacarpal (HP:0010012)1.61636520
180Embryonal renal neoplasm (HP:0011794)1.61588275
181Uterine leiomyosarcoma (HP:0002891)1.61347106
182Leiomyosarcoma (HP:0100243)1.61347106
183Sloping forehead (HP:0000340)1.61226410
184Abnormality of the diencephalon (HP:0010662)1.61115424
185Short middle phalanx of finger (HP:0005819)1.60654928
1862-3 toe syndactyly (HP:0004691)1.60221275
187Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.60180132
188Hemivertebrae (HP:0002937)1.60061252
189Midline defect of the nose (HP:0004122)1.59789965
190Abnormality of the septum pellucidum (HP:0007375)1.58770594
191Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.58669146
192Supernumerary spleens (HP:0009799)1.58163213
193Aplasia/Hypoplasia of the fibula (HP:0006492)1.55206983

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.02176825
2KSR14.31625329
3CASK4.01739765
4SIK34.01034508
5NTRK33.96192607
6NTRK13.90378039
7NTRK23.30621170
8MARK12.93768465
9MAP3K92.91430816
10PBK2.88277198
11TTK2.73159515
12PNCK2.68175028
13MKNK22.63602846
14WEE12.53027017
15MAP3K42.52835998
16MINK12.52380919
17CDC72.44019718
18BMPR1B2.35035978
19EIF2AK12.28318317
20PLK42.28096086
21KSR22.27045195
22FGFR22.16704102
23MKNK12.08315451
24TNIK2.00738377
25PRKD31.92675522
26CCNB11.91391315
27DAPK21.90727156
28BUB11.87258413
29LATS11.85490146
30EPHB21.77690662
31CAMKK11.71669831
32BCR1.64453271
33PAK61.64256713
34TAOK11.63513400
35MAP2K71.56569833
36NUAK11.45628061
37BRSK21.44062776
38CDK51.40811975
39PLK31.35716181
40SIK11.32398096
41BRD41.27764440
42FGFR11.26974991
43PLK11.26016232
44ERBB31.25749657
45SRPK11.25420278
46SIK21.23932580
47DAPK11.22259832
48EIF2AK31.18742291
49WNK31.17736829
50STK381.11003237
51ERBB21.09583401
52SGK21.09462673
53RAF11.08525112
54CHEK21.08390339
55TRIM281.05240691
56MAP3K21.04416377
57STK38L1.02599806
58TSSK61.02442396
59SGK31.00855664
60ERBB40.99768983
61DDR20.99751542
62CDK180.98172062
63NEK90.97446513
64MAP2K40.96694422
65CSNK1G10.95441416
66RIPK40.95023496
67LATS20.94689708
68FRK0.94660347
69FES0.94478545
70CAMKK20.93774610
71MAPK130.92219515
72MET0.91394325
73YES10.91384217
74SGK2230.91373611
75SGK4940.91373611
76CLK10.90134186
77STK30.88673967
78MAP3K130.88200087
79TGFBR10.87409818
80ATM0.86036103
81CSNK1G30.80962780
82PLK20.77093619
83NEK10.75741868
84PHKG10.75621697
85PHKG20.75621697
86CDK150.75557988
87PRKCG0.74648047
88ROCK10.73839296
89CAMK10.73725230
90ATR0.73135362
91CSNK1A1L0.72813217
92RET0.72765183
93SGK10.72514624
94MARK20.72242121
95PRPF4B0.71623665
96PINK10.71585943
97STK110.71326745
98MST40.71065568
99INSRR0.70607960
100DMPK0.69979080
101TYRO30.69845130
102CDK140.69005296
103RIPK10.68982245
104ALK0.68538855
105CAMK2A0.66866453
106PDGFRA0.66720295
107PRKCH0.66057107
108CDK11A0.64594007
109STK390.64493446
110CHEK10.63232253
111ACVR1B0.60850158
112EIF2AK20.59531498
113CAMK1G0.59503952
114GRK10.58650181
115RPS6KA40.56680910
116LMTK20.55086134
117CDK10.54474511
118AKT30.53949573
119MAP3K70.53595599
120DYRK20.53558236
121ZAK0.53461280
122AURKB0.52325525
123NEK20.52212981
124ICK0.50487251
125NEK60.50467271
126CDK80.50220335
127CDK30.50050900
128PAK20.49343166
129FYN0.49052661
130MAP3K100.48804877
131PRKCZ0.48466310
132MOS0.48354527
133RPS6KA30.48313419
134MATK0.48087073
135ROCK20.47716217
136MAPK100.47002251
137WNK10.46998122
138PRKDC0.45449393
139SCYL20.44375655
140CAMK40.43309735
141CDK70.43002634
142PDK20.42480471
143FER0.42071885
144PKN10.40657504
145UHMK10.39898042
146MAP3K10.39188702
147PTK2B0.38535257
148TRIB30.37881096
149CSNK1G20.37769188
150MAP3K80.37641647
151DYRK1A0.37563580
152MAP3K60.36716624
153CSNK1E0.36443087
154BRSK10.36069559
155CDK20.35863422
156MAPK80.35510067
157PDK10.34780933
158PRKCB0.34746849
159BRAF0.34724388
160VRK10.33862344
161CDC42BPA0.31670481
162CDK190.31242670
163GSK3B0.29587624
164MUSK0.28901377
165MAPK90.28642370
166PAK30.28361956
167SRC0.28331201
168GRK50.27328719
169CAMK1D0.26489105
170MAPK120.26271930
171CAMK2B0.25446094
172MAP2K10.25065767
173PRKCE0.24943349

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.67544183
2Steroid biosynthesis_Homo sapiens_hsa001003.66872439
3Olfactory transduction_Homo sapiens_hsa047402.99941428
4Nicotine addiction_Homo sapiens_hsa050332.88334076
5Circadian entrainment_Homo sapiens_hsa047132.74955161
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.70902579
7Mismatch repair_Homo sapiens_hsa034302.47314270
8Long-term potentiation_Homo sapiens_hsa047202.41091332
9Fanconi anemia pathway_Homo sapiens_hsa034602.39812950
10Morphine addiction_Homo sapiens_hsa050322.35571163
11Glutamatergic synapse_Homo sapiens_hsa047242.34401374
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28562994
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.25959594
14GABAergic synapse_Homo sapiens_hsa047272.23558033
15Amphetamine addiction_Homo sapiens_hsa050312.22742904
16Cell cycle_Homo sapiens_hsa041102.22027596
17Synaptic vesicle cycle_Homo sapiens_hsa047212.21630056
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.21489176
19Propanoate metabolism_Homo sapiens_hsa006402.16884175
20DNA replication_Homo sapiens_hsa030302.08188898
21Dopaminergic synapse_Homo sapiens_hsa047282.07215225
22Homologous recombination_Homo sapiens_hsa034402.04994266
23Cholinergic synapse_Homo sapiens_hsa047252.01473387
24Salivary secretion_Homo sapiens_hsa049701.95285319
25Non-homologous end-joining_Homo sapiens_hsa034501.94065921
26Cocaine addiction_Homo sapiens_hsa050301.86834671
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79673926
28Oxytocin signaling pathway_Homo sapiens_hsa049211.74497339
29Basal transcription factors_Homo sapiens_hsa030221.72791451
30Protein export_Homo sapiens_hsa030601.69248300
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67323650
32Calcium signaling pathway_Homo sapiens_hsa040201.63830463
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62662239
34Hedgehog signaling pathway_Homo sapiens_hsa043401.62164117
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.61015446
36Renin secretion_Homo sapiens_hsa049241.59465886
37Vitamin B6 metabolism_Homo sapiens_hsa007501.58198785
38Insulin secretion_Homo sapiens_hsa049111.57837448
39Long-term depression_Homo sapiens_hsa047301.55072987
40Glioma_Homo sapiens_hsa052141.55035736
41Nucleotide excision repair_Homo sapiens_hsa034201.53960907
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.50492217
43One carbon pool by folate_Homo sapiens_hsa006701.46869877
44Gastric acid secretion_Homo sapiens_hsa049711.46563297
45Pyruvate metabolism_Homo sapiens_hsa006201.45341767
46Gap junction_Homo sapiens_hsa045401.42894836
47RNA transport_Homo sapiens_hsa030131.42544171
48cAMP signaling pathway_Homo sapiens_hsa040241.39548856
49GnRH signaling pathway_Homo sapiens_hsa049121.38046275
50Serotonergic synapse_Homo sapiens_hsa047261.33684725
51Adherens junction_Homo sapiens_hsa045201.32122758
52ErbB signaling pathway_Homo sapiens_hsa040121.30882589
53Type II diabetes mellitus_Homo sapiens_hsa049301.29774575
54TGF-beta signaling pathway_Homo sapiens_hsa043501.26871767
55MicroRNAs in cancer_Homo sapiens_hsa052061.26667545
56Axon guidance_Homo sapiens_hsa043601.26633073
57cGMP-PKG signaling pathway_Homo sapiens_hsa040221.26466210
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.26310888
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25401879
60Estrogen signaling pathway_Homo sapiens_hsa049151.21518879
61Taste transduction_Homo sapiens_hsa047421.19949972
62Dilated cardiomyopathy_Homo sapiens_hsa054141.18133510
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16569575
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16349363
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16085860
66Butanoate metabolism_Homo sapiens_hsa006501.15323549
67Fatty acid elongation_Homo sapiens_hsa000621.15005601
68Melanogenesis_Homo sapiens_hsa049161.10778590
69Fatty acid metabolism_Homo sapiens_hsa012121.10542017
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07172360
71Oocyte meiosis_Homo sapiens_hsa041141.05780767
72Non-small cell lung cancer_Homo sapiens_hsa052231.05298039
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04265877
74Cysteine and methionine metabolism_Homo sapiens_hsa002701.03664862
75RNA degradation_Homo sapiens_hsa030181.03299864
76Dorso-ventral axis formation_Homo sapiens_hsa043201.03258107
77Phospholipase D signaling pathway_Homo sapiens_hsa040721.03141777
78Spliceosome_Homo sapiens_hsa030401.00594185
79Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00386636
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.99368553
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99193707
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98637061
83Lysine degradation_Homo sapiens_hsa003100.98474489
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98259137
85RNA polymerase_Homo sapiens_hsa030200.97121827
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91301779
87mRNA surveillance pathway_Homo sapiens_hsa030150.90929667
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88306399
89mTOR signaling pathway_Homo sapiens_hsa041500.87507660
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86677919
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.85089774
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85069412
93Base excision repair_Homo sapiens_hsa034100.84525387
94Endometrial cancer_Homo sapiens_hsa052130.84194960
95Choline metabolism in cancer_Homo sapiens_hsa052310.81837967
96p53 signaling pathway_Homo sapiens_hsa041150.81761431
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80811507
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79886550
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78980524
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76139127
101Tight junction_Homo sapiens_hsa045300.76031806
102Chronic myeloid leukemia_Homo sapiens_hsa052200.75262996
103Alcoholism_Homo sapiens_hsa050340.74320285
104MAPK signaling pathway_Homo sapiens_hsa040100.73256718
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72790102
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72574946
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71529475
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70814030
109VEGF signaling pathway_Homo sapiens_hsa043700.70112586
110Prostate cancer_Homo sapiens_hsa052150.69349606
111Rap1 signaling pathway_Homo sapiens_hsa040150.68931121
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67687370
113Melanoma_Homo sapiens_hsa052180.67599289
114Renal cell carcinoma_Homo sapiens_hsa052110.66537809
115Ras signaling pathway_Homo sapiens_hsa040140.65564316
116Cardiac muscle contraction_Homo sapiens_hsa042600.64739552
117Circadian rhythm_Homo sapiens_hsa047100.64344584
118Wnt signaling pathway_Homo sapiens_hsa043100.63834539
119Colorectal cancer_Homo sapiens_hsa052100.63657615
120Thyroid hormone synthesis_Homo sapiens_hsa049180.61914220
121Insulin signaling pathway_Homo sapiens_hsa049100.61096012
122Carbon metabolism_Homo sapiens_hsa012000.60482969
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59994292
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59012991
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58647666
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58491955
127Pathways in cancer_Homo sapiens_hsa052000.57046115
128Pancreatic secretion_Homo sapiens_hsa049720.56509980
129Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55796594
130Chemokine signaling pathway_Homo sapiens_hsa040620.54725907
131Focal adhesion_Homo sapiens_hsa045100.53715224
132Hippo signaling pathway_Homo sapiens_hsa043900.52581216
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.51681284
134Glucagon signaling pathway_Homo sapiens_hsa049220.51253595
135Nitrogen metabolism_Homo sapiens_hsa009100.50235500
136Biosynthesis of amino acids_Homo sapiens_hsa012300.50058550
137Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49536457
138ECM-receptor interaction_Homo sapiens_hsa045120.47442648
139Platelet activation_Homo sapiens_hsa046110.46403842
140Prolactin signaling pathway_Homo sapiens_hsa049170.45602123
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44946104
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.44461433
143Inositol phosphate metabolism_Homo sapiens_hsa005620.44420662
144Ovarian steroidogenesis_Homo sapiens_hsa049130.44307132
145Pancreatic cancer_Homo sapiens_hsa052120.43945812
146Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43487924
147Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42891737
148Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41456904
149Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41163566
150Purine metabolism_Homo sapiens_hsa002300.41157254
151Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40859840
152Basal cell carcinoma_Homo sapiens_hsa052170.40577592
153Proteoglycans in cancer_Homo sapiens_hsa052050.40153495
154Small cell lung cancer_Homo sapiens_hsa052220.39534352
155Selenocompound metabolism_Homo sapiens_hsa004500.38562205
156PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38485486
157Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37863951
158Protein digestion and absorption_Homo sapiens_hsa049740.37385065
159Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36918066
160AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35312252
161Bladder cancer_Homo sapiens_hsa052190.35303433
162Thyroid cancer_Homo sapiens_hsa052160.34868749

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