ADAMTS4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.81778759
2ensheathment of neurons (GO:0007272)7.51321858
3axon ensheathment (GO:0008366)7.51321858
4myelination (GO:0042552)7.50161497
5negative regulation of neurotransmitter secretion (GO:0046929)5.69406841
6long-chain fatty acid biosynthetic process (GO:0042759)5.66611581
7behavioral response to nicotine (GO:0035095)5.33453682
8cholesterol biosynthetic process (GO:0006695)4.87455318
9oligodendrocyte differentiation (GO:0048709)4.77038254
10glycerophospholipid catabolic process (GO:0046475)4.70129151
11negative regulation of neurotransmitter transport (GO:0051589)4.64650113
12myelination in peripheral nervous system (GO:0022011)4.59837688
13peripheral nervous system axon ensheathment (GO:0032292)4.59837688
14adhesion of symbiont to host cell (GO:0044650)4.57057668
15virion attachment to host cell (GO:0019062)4.57057668
16myelin maintenance (GO:0043217)4.55495786
17negative regulation of peptidyl-threonine phosphorylation (GO:0010801)4.46981504
18peptidyl-tyrosine autophosphorylation (GO:0038083)4.40462409
19astrocyte development (GO:0014002)4.39409092
20eye photoreceptor cell differentiation (GO:0001754)4.38738480
21photoreceptor cell differentiation (GO:0046530)4.38738480
22substantia nigra development (GO:0021762)4.31715913
23regulation of collateral sprouting (GO:0048670)4.31264321
24sterol biosynthetic process (GO:0016126)4.28769480
25response to redox state (GO:0051775)4.18891483
26presynaptic membrane assembly (GO:0097105)4.18416422
27creatine metabolic process (GO:0006600)4.12962005
28presynaptic membrane organization (GO:0097090)4.08569821
29L-amino acid import (GO:0043092)4.01057464
30tryptophan catabolic process (GO:0006569)3.98061620
31indole-containing compound catabolic process (GO:0042436)3.98061620
32indolalkylamine catabolic process (GO:0046218)3.98061620
33kynurenine metabolic process (GO:0070189)3.97831574
34negative regulation of protein localization to cell surface (GO:2000009)3.94404494
35gamma-aminobutyric acid transport (GO:0015812)3.93957841
36long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.90215273
37asymmetric protein localization (GO:0008105)3.88709391
38positive regulation of chemokine secretion (GO:0090197)3.86888261
39negative regulation of macrophage differentiation (GO:0045650)3.76697758
40import into cell (GO:0098657)3.75521409
41transmission of nerve impulse (GO:0019226)3.70567099
42isoprenoid biosynthetic process (GO:0008299)3.70439286
43amyloid precursor protein metabolic process (GO:0042982)3.65494936
44apical protein localization (GO:0045176)3.60618083
45cellular response to epinephrine stimulus (GO:0071872)3.57701792
46indolalkylamine metabolic process (GO:0006586)3.57432437
47L-fucose catabolic process (GO:0042355)3.57335080
48fucose catabolic process (GO:0019317)3.57335080
49L-fucose metabolic process (GO:0042354)3.57335080
50response to lipoprotein particle (GO:0055094)3.53125901
51adhesion of symbiont to host (GO:0044406)3.52685724
52tryptophan metabolic process (GO:0006568)3.52021970
53negative regulation of axonogenesis (GO:0050771)3.51880961
54long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.48025779
55neuronal ion channel clustering (GO:0045161)3.48018633
56positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.47255979
57response to hepatocyte growth factor (GO:0035728)3.41913887
58cellular response to hepatocyte growth factor stimulus (GO:0035729)3.41913887
59positive regulation of action potential (GO:0045760)3.41311424
60establishment of mitochondrion localization (GO:0051654)3.37429843
61positive regulation of oligodendrocyte differentiation (GO:0048714)3.35790287
62fatty-acyl-CoA biosynthetic process (GO:0046949)3.35301469
63amine catabolic process (GO:0009310)3.33808598
64cellular biogenic amine catabolic process (GO:0042402)3.33808598
65detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.33424484
66regulation of posttranscriptional gene silencing (GO:0060147)3.31744598
67regulation of gene silencing by miRNA (GO:0060964)3.31744598
68regulation of gene silencing by RNA (GO:0060966)3.31744598
69regulation of endothelial cell differentiation (GO:0045601)3.31517625
70leukocyte migration involved in inflammatory response (GO:0002523)3.28844975
71protein palmitoylation (GO:0018345)3.26592117
72limb bud formation (GO:0060174)3.25711465
73magnesium ion transport (GO:0015693)3.25392186
74negative regulation of axon extension (GO:0030517)3.24384505
75positive regulation of macrophage activation (GO:0043032)3.20926743
76positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.20808424
77cerebral cortex radially oriented cell migration (GO:0021799)3.19371476
78positive regulation of sodium ion transmembrane transport (GO:1902307)3.17353005
79Rap protein signal transduction (GO:0032486)3.17104848
80regulation of hippo signaling (GO:0035330)3.15839684
81response to methylmercury (GO:0051597)3.15001319
82peripheral nervous system development (GO:0007422)3.13335367
83cellular response to sterol (GO:0036315)3.10705513
84regulation of chemokine secretion (GO:0090196)3.07946305
85negative regulation of mast cell activation (GO:0033004)3.07574324
86cAMP catabolic process (GO:0006198)3.07442073
87response to epinephrine (GO:0071871)3.05021113
88indole-containing compound metabolic process (GO:0042430)3.04591011
89lymphangiogenesis (GO:0001946)3.04163822
90membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.03716612
91membrane tubulation (GO:0097320)3.03509328
92adult walking behavior (GO:0007628)3.02179826
93cellular response to ATP (GO:0071318)3.01310545
94interleukin-6-mediated signaling pathway (GO:0070102)2.99304620
95fatty-acyl-CoA metabolic process (GO:0035337)2.98884771
96positive regulation of actin filament depolymerization (GO:0030836)2.96928797
97endocrine hormone secretion (GO:0060986)2.96580618
98amino acid import (GO:0043090)2.96228515
99membrane assembly (GO:0071709)2.95275010
100nephron tubule morphogenesis (GO:0072078)2.95166255
101nephron epithelium morphogenesis (GO:0072088)2.95166255
102negative regulation of systemic arterial blood pressure (GO:0003085)2.93970143
103primary amino compound metabolic process (GO:1901160)2.93835570
104glycosylceramide metabolic process (GO:0006677)2.93461847
105cellular response to cholesterol (GO:0071397)2.92092453
106negative regulation of JUN kinase activity (GO:0043508)2.90449595
107nerve growth factor signaling pathway (GO:0038180)2.88010166
108nucleotide transmembrane transport (GO:1901679)2.87190560
109cellular ketone body metabolic process (GO:0046950)2.85830465
110cyclic nucleotide catabolic process (GO:0009214)2.85817042
111neural nucleus development (GO:0048857)2.85169939
112neuron cell-cell adhesion (GO:0007158)2.84781770
113cerebellar granule cell differentiation (GO:0021707)2.84659112
114serotonin metabolic process (GO:0042428)2.84005445
115behavioral response to ethanol (GO:0048149)2.83012780
116glial cell development (GO:0021782)2.82440294
117cellular response to zinc ion (GO:0071294)2.82028118
118negative regulation of synaptic transmission, GABAergic (GO:0032229)2.81638630
119axon development (GO:0061564)2.76194702
120negative regulation of axon extension involved in axon guidance (GO:0048843)2.75528021
121G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.74175122
122neuronal action potential (GO:0019228)2.73467117
123response to pheromone (GO:0019236)2.73426309
124ear development (GO:0043583)2.73046552
125sulfation (GO:0051923)2.72682333
126detection of light stimulus involved in visual perception (GO:0050908)2.72117429
127detection of light stimulus involved in sensory perception (GO:0050962)2.72117429
128cellular response to monoamine stimulus (GO:0071868)2.70494340
129cellular response to catecholamine stimulus (GO:0071870)2.70494340
130amyloid precursor protein catabolic process (GO:0042987)2.69875107
131very long-chain fatty acid metabolic process (GO:0000038)2.68923745
132positive regulation of protein kinase C signaling (GO:0090037)2.68434931
133peptidyl-cysteine modification (GO:0018198)2.67990787
134negative regulation of translation, ncRNA-mediated (GO:0040033)2.66919539
135regulation of translation, ncRNA-mediated (GO:0045974)2.66919539
136negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.66919539
137Leydig cell differentiation (GO:0033327)2.65861896
138neuron remodeling (GO:0016322)2.65301178
139NAD biosynthetic process (GO:0009435)2.64469932
140UDP-N-acetylglucosamine metabolic process (GO:0006047)2.64440203
141negative regulation of Rho protein signal transduction (GO:0035024)2.63282060
142organ growth (GO:0035265)2.63242323
143platelet dense granule organization (GO:0060155)2.63043741
144Golgi to plasma membrane protein transport (GO:0043001)2.59687460
145acyl-CoA biosynthetic process (GO:0071616)2.58825113
146thioester biosynthetic process (GO:0035384)2.58825113
147glial cell differentiation (GO:0010001)2.58759393
148neurotransmitter catabolic process (GO:0042135)2.58522741
149macroautophagy (GO:0016236)2.56864199
150positive regulation of triglyceride biosynthetic process (GO:0010867)2.56711618
151regulation of mesoderm development (GO:2000380)2.56185476
152enteric nervous system development (GO:0048484)2.55239692
153positive regulation of interleukin-17 production (GO:0032740)2.54755618
154activated T cell proliferation (GO:0050798)2.54738067
155positive regulation of glial cell differentiation (GO:0045687)2.53381443
156peristalsis (GO:0030432)2.53215129
157dermatan sulfate biosynthetic process (GO:0030208)2.52906806
158GPI anchor biosynthetic process (GO:0006506)2.52351206
159kidney morphogenesis (GO:0060993)2.51874699
160positive regulation of neurological system process (GO:0031646)2.51788420
161renal tubule morphogenesis (GO:0061333)2.51531310
162regulation of action potential (GO:0098900)2.50629419
163GPI anchor metabolic process (GO:0006505)2.50106685
164semaphorin-plexin signaling pathway (GO:0071526)2.49690155
165epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.49626685
166ketone body metabolic process (GO:1902224)2.49203773
167glomerular filtration (GO:0003094)2.49050738
168vocalization behavior (GO:0071625)2.48270937
169regulation of T-helper 1 type immune response (GO:0002825)2.47595059
170negative regulation of telomere maintenance (GO:0032205)2.47093647
171negative regulation of axon guidance (GO:1902668)2.46949414
172neuronal action potential propagation (GO:0019227)2.46891551
173regulation of gonadotropin secretion (GO:0032276)2.46071341
174reflex (GO:0060004)2.45089467
175ovulation from ovarian follicle (GO:0001542)2.43655793
176regulation of triglyceride biosynthetic process (GO:0010866)2.43211016
177endoderm formation (GO:0001706)2.38771094
178multicellular organism reproduction (GO:0032504)2.37646426
179cellular response to cadmium ion (GO:0071276)2.37101491
180regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.36262347
181phasic smooth muscle contraction (GO:0014821)2.34557777
182response to caffeine (GO:0031000)2.34472725
183postsynaptic membrane organization (GO:0001941)2.33546757
184negative regulation of smooth muscle cell differentiation (GO:0051151)2.32862358
185ovulation cycle (GO:0042698)2.32637094
186atrial cardiac muscle cell action potential (GO:0086014)2.32606742
187activin receptor signaling pathway (GO:0032924)2.31491291
188urinary tract smooth muscle contraction (GO:0014848)2.30882012
189phosphatidylinositol acyl-chain remodeling (GO:0036149)2.30452034
190neuron maturation (GO:0042551)2.29342166
191cornea development in camera-type eye (GO:0061303)2.29268639
192detection of mechanical stimulus involved in sensory perception (GO:0050974)2.26781068
193central nervous system myelination (GO:0022010)10.2988069
194axon ensheathment in central nervous system (GO:0032291)10.2988069

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.36832928
2ZNF274_21170338_ChIP-Seq_K562_Hela3.02344155
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.82792975
4SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.76510489
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.50928546
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.37667711
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.27490547
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.25885172
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.25281337
10TAF15_26573619_Chip-Seq_HEK293_Human2.21597723
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.17395042
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.10750493
13OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.07048419
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.06836495
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.06836495
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.00296026
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00255506
18EED_16625203_ChIP-ChIP_MESCs_Mouse1.99533004
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.99252697
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.98071116
21AR_21572438_ChIP-Seq_LNCaP_Human1.95299047
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.95209656
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.86042108
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85588463
25DROSHA_22980978_ChIP-Seq_HELA_Human1.83130820
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82915418
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.82259465
28EZH2_22144423_ChIP-Seq_EOC_Human1.81681480
29ER_23166858_ChIP-Seq_MCF-7_Human1.81586447
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79921942
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76693372
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.76238929
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.67934925
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.67791930
35VDR_22108803_ChIP-Seq_LS180_Human1.66715678
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65904217
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62257213
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.58986414
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.56695663
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55946031
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.54397458
42BCAT_22108803_ChIP-Seq_LS180_Human1.53662807
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.52842069
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.52505284
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52173012
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51287352
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.47465471
48STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.47319182
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.47103634
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44083808
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42244017
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37529705
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37464517
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37464517
55EP300_21415370_ChIP-Seq_HL-1_Mouse1.37446019
56AR_25329375_ChIP-Seq_VCAP_Human1.37060332
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36478844
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35440164
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34713591
60PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.33849893
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32102369
62CJUN_26792858_Chip-Seq_BT549_Human1.31917873
63EWS_26573619_Chip-Seq_HEK293_Human1.31484455
64TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30432404
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.29149205
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.29149205
67FUS_26573619_Chip-Seq_HEK293_Human1.28672245
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27064309
69P300_19829295_ChIP-Seq_ESCs_Human1.24161850
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22804830
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22787047
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22685006
73EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22559415
74FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.20657989
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19432045
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.15306801
77IGF1R_20145208_ChIP-Seq_DFB_Human1.14031424
78RARB_27405468_Chip-Seq_BRAIN_Mouse1.13867811
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13526121
80IRF8_22096565_ChIP-ChIP_GC-B_Human1.13475365
81TCF4_22108803_ChIP-Seq_LS180_Human1.13464055
82CBP_20019798_ChIP-Seq_JUKART_Human1.13414997
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13414997
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.13413359
85STAT3_23295773_ChIP-Seq_U87_Human1.13349744
86* SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.11718220
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10656582
88P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10219338
89CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08052546
90* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07919556
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07763729
92NANOG_19829295_ChIP-Seq_ESCs_Human1.07109613
93SOX2_19829295_ChIP-Seq_ESCs_Human1.07109613
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06929050
95ESR1_21235772_ChIP-Seq_MCF-7_Human1.06446546
96BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05973255
97FLI1_21867929_ChIP-Seq_TH2_Mouse1.05669848
98BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01635143
99KDM2B_26808549_Chip-Seq_REH_Human1.00646572
100EOMES_21245162_ChIP-Seq_HESCs_Human0.99809473
101TP53_16413492_ChIP-PET_HCT116_Human0.99756660
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99637172
103RNF2_27304074_Chip-Seq_NSC_Mouse0.98875737
104ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98798125
105GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98548929
106RING1B_27294783_Chip-Seq_NPCs_Mouse0.98488407
107SMAD3_21741376_ChIP-Seq_HESCs_Human0.97861264
108GATA3_21878914_ChIP-Seq_MCF-7_Human0.97757753
109* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97676449
110SMAD4_21799915_ChIP-Seq_A2780_Human0.97023218
111TAL1_26923725_Chip-Seq_HPCs_Mouse0.96722689
112TCF4_23295773_ChIP-Seq_U87_Human0.96662816
113CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96118072
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95118851
115LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94465903
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94403217
117* CMYC_18555785_Chip-Seq_ESCs_Mouse0.94224256
118MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92408621
119EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92363272
120* NANOG_18555785_Chip-Seq_ESCs_Mouse0.92306123
121LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92302655
122AHR_22903824_ChIP-Seq_MCF-7_Human0.92301974
123NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90811863
124HTT_18923047_ChIP-ChIP_STHdh_Human0.89933794
125TBL1_22424771_ChIP-Seq_293T_Human0.89785713
126* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89526239
127TP53_18474530_ChIP-ChIP_U2OS_Human0.89456299
128ARNT_22903824_ChIP-Seq_MCF-7_Human0.88556759
129RING1B_27294783_Chip-Seq_ESCs_Mouse0.88419340
130PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88312756
131* REST_21632747_ChIP-Seq_MESCs_Mouse0.88227922
132* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88100212
133HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87843751
134PRDM14_20953172_ChIP-Seq_ESCs_Human0.86642248
135ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85683147
136RUNX2_22187159_ChIP-Seq_PCA_Human0.85339330
137UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85143138
138SMAD4_21741376_ChIP-Seq_EPCs_Human0.85121505
139SOX2_21211035_ChIP-Seq_LN229_Gbm0.84806591

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.69794013
2MP0003880_abnormal_central_pattern3.69716897
3MP0003690_abnormal_glial_cell3.56734426
4MP0004270_analgesia3.40801193
5MP0005670_abnormal_white_adipose3.32454714
6MP0003950_abnormal_plasma_membrane3.30465309
7MP0004885_abnormal_endolymph2.96485536
8MP0003011_delayed_dark_adaptation2.83373747
9MP0004742_abnormal_vestibular_system2.71115155
10MP0005171_absent_coat_pigmentation2.68331571
11MP0001879_abnormal_lymphatic_vessel2.63172079
12MP0003329_amyloid_beta_deposits2.62744189
13MP0003136_yellow_coat_color2.52656227
14MP0001485_abnormal_pinna_reflex2.48801209
15MP0001501_abnormal_sleep_pattern2.47742349
16MP0005167_abnormal_blood-brain_barrier2.46879800
17MP0003634_abnormal_glial_cell2.46582428
18MP0008438_abnormal_cutaneous_collagen2.39324649
19MP0003646_muscle_fatigue2.37093804
20MP0001529_abnormal_vocalization2.37067131
21MP0002272_abnormal_nervous_system2.33700065
22MP0001486_abnormal_startle_reflex2.31610395
23MP0001905_abnormal_dopamine_level2.28269975
24MP0000778_abnormal_nervous_system2.27442250
25MP0000462_abnormal_digestive_system2.15724106
26MP0005409_darkened_coat_color2.14719429
27MP0010368_abnormal_lymphatic_system2.04420502
28MP0003632_abnormal_nervous_system2.03139964
29MP0004859_abnormal_synaptic_plasticity2.02692921
30MP0000383_abnormal_hair_follicle1.97943886
31MP0004142_abnormal_muscle_tone1.93532299
32MP0005187_abnormal_penis_morphology1.90771438
33MP0010678_abnormal_skin_adnexa1.89863507
34MP0005451_abnormal_body_composition1.88642965
35* MP0002064_seizures1.86699579
36MP0002735_abnormal_chemical_nociception1.82538466
37MP0002876_abnormal_thyroid_physiology1.78260857
38MP0004215_abnormal_myocardial_fiber1.75992347
39MP0002254_reproductive_system_inflammat1.74801741
40MP0005595_abnormal_vascular_smooth1.70257562
41MP0002229_neurodegeneration1.70253086
42MP0001968_abnormal_touch/_nociception1.70028029
43MP0002653_abnormal_ependyma_morphology1.69004768
44MP0009046_muscle_twitch1.67786694
45MP0001299_abnormal_eye_distance/1.64198400
46MP0005623_abnormal_meninges_morphology1.62457926
47MP0008877_abnormal_DNA_methylation1.61239397
48MP0008872_abnormal_physiological_respon1.58953519
49MP0008775_abnormal_heart_ventricle1.57639691
50MP0004134_abnormal_chest_morphology1.55026036
51MP0002734_abnormal_mechanical_nocicepti1.54380303
52MP0000569_abnormal_digit_pigmentation1.51869322
53MP0002102_abnormal_ear_morphology1.51784102
54MP0001986_abnormal_taste_sensitivity1.50262818
55MP0003724_increased_susceptibility_to1.47543899
56MP0003635_abnormal_synaptic_transmissio1.45020116
57MP0002638_abnormal_pupillary_reflex1.44279938
58MP0004147_increased_porphyrin_level1.43705924
59MP0000955_abnormal_spinal_cord1.41355070
60MP0005084_abnormal_gallbladder_morpholo1.39851245
61MP0005410_abnormal_fertilization1.38971289
62MP0004130_abnormal_muscle_cell1.37908734
63MP0004272_abnormal_basement_membrane1.37325243
64MP0000230_abnormal_systemic_arterial1.36034258
65MP0002837_dystrophic_cardiac_calcinosis1.33559634
66MP0002882_abnormal_neuron_morphology1.33153695
67MP0000604_amyloidosis1.32311177
68* MP0009745_abnormal_behavioral_response1.30625160
69MP0005551_abnormal_eye_electrophysiolog1.30372396
70MP0001346_abnormal_lacrimal_gland1.30022349
71MP0001440_abnormal_grooming_behavior1.25607178
72MP0003279_aneurysm1.24421197
73MP0002295_abnormal_pulmonary_circulatio1.24361172
74MP0004381_abnormal_hair_follicle1.23710637
75MP0001851_eye_inflammation1.22691734
76MP0003631_nervous_system_phenotype1.22507363
77MP0004084_abnormal_cardiac_muscle1.21476876
78MP0000747_muscle_weakness1.20427048
79MP0000566_synostosis1.19349556
80MP0002736_abnormal_nociception_after1.17486474
81MP0005423_abnormal_somatic_nervous1.17129966
82MP0008875_abnormal_xenobiotic_pharmacok1.13157560
83MP0001661_extended_life_span1.12227963
84MP0001963_abnormal_hearing_physiology1.11997985
85* MP0002066_abnormal_motor_capabilities/c1.11431914
86MP0002752_abnormal_somatic_nervous1.11428338
87MP0003937_abnormal_limbs/digits/tail_de1.10775540
88MP0006054_spinal_hemorrhage1.09869935
89MP0000647_abnormal_sebaceous_gland1.08198350
90MP0003938_abnormal_ear_development1.07395123
91MP0002572_abnormal_emotion/affect_behav1.05130549
92MP0005448_abnormal_energy_balance1.05046593
93MP0001177_atelectasis1.04769042
94MP0005645_abnormal_hypothalamus_physiol1.04697471
95MP0004924_abnormal_behavior1.04121287
96MP0005386_behavior/neurological_phenoty1.04121287
97MP0009764_decreased_sensitivity_to1.04088623
98MP0005174_abnormal_tail_pigmentation1.00905941
99MP0003195_calcinosis1.00814412
100MP0003283_abnormal_digestive_organ1.00568985
101MP0002067_abnormal_sensory_capabilities0.99559077
102MP0000427_abnormal_hair_cycle0.99362788
103MP0003137_abnormal_impulse_conducting0.97387653
104MP0000762_abnormal_tongue_morphology0.96856703
105MP0001502_abnormal_circadian_rhythm0.96770676
106MP0002277_abnormal_respiratory_mucosa0.96731034
107MP0005195_abnormal_posterior_eye0.96604635
108MP0002108_abnormal_muscle_morphology0.95528565
109MP0008569_lethality_at_weaning0.95364324
110MP0002063_abnormal_learning/memory/cond0.94878641
111MP0005503_abnormal_tendon_morphology0.94443729
112MP0005377_hearing/vestibular/ear_phenot0.93392091
113MP0003878_abnormal_ear_physiology0.93392091
114MP0000467_abnormal_esophagus_morphology0.92929574
115MP0005408_hypopigmentation0.91404365
116MP0004145_abnormal_muscle_electrophysio0.88707689
117MP0000631_abnormal_neuroendocrine_gland0.88086347
118MP0010329_abnormal_lipoprotein_level0.87881523
119MP0005646_abnormal_pituitary_gland0.86907014
120MP0003787_abnormal_imprinting0.85012614
121MP0001727_abnormal_embryo_implantation0.84849090
122MP0003633_abnormal_nervous_system0.84740223
123MP0004085_abnormal_heartbeat0.81281408
124MP0006276_abnormal_autonomic_nervous0.81194941
125MP0009250_abnormal_appendicular_skeleto0.79817478
126MP0000026_abnormal_inner_ear0.78821130
127MP0000343_altered_response_to0.78703799
128MP0002557_abnormal_social/conspecific_i0.78653212
129MP0002160_abnormal_reproductive_system0.78197728
130MP0001970_abnormal_pain_threshold0.77928273
131MP0002152_abnormal_brain_morphology0.77464554
132MP0002090_abnormal_vision0.77138975
133MP0002138_abnormal_hepatobiliary_system0.76934703
134MP0005388_respiratory_system_phenotype0.76923409
135MP0002133_abnormal_respiratory_system0.76923409
136MP0000049_abnormal_middle_ear0.76022099
137MP0004043_abnormal_pH_regulation0.75352486
138MP0004185_abnormal_adipocyte_glucose0.75310530
139MP0001348_abnormal_lacrimal_gland0.74201388
140MP0003806_abnormal_nucleotide_metabolis0.73073161
141MP0005058_abnormal_lysosome_morphology0.72600860
142MP0000767_abnormal_smooth_muscle0.71554677
143MP0003119_abnormal_digestive_system0.70873528
144MP0002938_white_spotting0.70608660
145MP0009384_cardiac_valve_regurgitation0.70264033
146MP0005620_abnormal_muscle_contractility0.69626341
147MP0006072_abnormal_retinal_apoptosis0.69330809
148MP0002733_abnormal_thermal_nociception0.68225746
149MP0008260_abnormal_autophagy0.67438872
150MP0000733_abnormal_muscle_development0.67295910
151MP0004133_heterotaxia0.67276463
152MP0000579_abnormal_nail_morphology0.64051934
153MP0005253_abnormal_eye_physiology0.62472788
154MP0003385_abnormal_body_wall0.61254033
155MP0000003_abnormal_adipose_tissue0.59916618
156MP0002933_joint_inflammation0.57468496
157MP0001340_abnormal_eyelid_morphology0.56528430
158MP0002184_abnormal_innervation0.54324698

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.93532021
2Degeneration of the lateral corticospinal tracts (HP:0002314)6.93532021
3Sensory axonal neuropathy (HP:0003390)5.96365476
4Neurofibrillary tangles (HP:0002185)5.81033900
5Parakeratosis (HP:0001036)5.14442428
6Abnormality of the corticospinal tract (HP:0002492)5.13794979
7Congenital, generalized hypertrichosis (HP:0004540)4.47073437
8Congenital stationary night blindness (HP:0007642)4.42118557
9Pancreatic cysts (HP:0001737)4.36933865
10Peripheral hypomyelination (HP:0007182)4.19879800
11Cerebral inclusion bodies (HP:0100314)4.10085830
12Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.99519747
13Pancreatic fibrosis (HP:0100732)3.92616179
14Nephronophthisis (HP:0000090)3.84793351
15True hermaphroditism (HP:0010459)3.79039223
16Abnormality of midbrain morphology (HP:0002418)3.77223741
17Molar tooth sign on MRI (HP:0002419)3.77223741
18Birth length less than 3rd percentile (HP:0003561)3.74165575
19Onion bulb formation (HP:0003383)3.72854584
20Akinesia (HP:0002304)3.67323577
21Cerebral hypomyelination (HP:0006808)3.62507980
22Spastic gait (HP:0002064)3.58810231
23Abnormality of the renal medulla (HP:0100957)3.47315915
24Abnormality of alanine metabolism (HP:0010916)3.46152772
25Hyperalaninemia (HP:0003348)3.46152772
26Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.46152772
27Tubular atrophy (HP:0000092)3.42589210
28Hyperventilation (HP:0002883)3.39902204
29Large for gestational age (HP:0001520)3.38156207
30Alacrima (HP:0000522)3.31495835
31Genetic anticipation (HP:0003743)3.29186284
32Increased corneal curvature (HP:0100692)3.28660176
33Keratoconus (HP:0000563)3.28660176
34Intention tremor (HP:0002080)3.24705772
35Supranuclear gaze palsy (HP:0000605)3.22279552
36Premature skin wrinkling (HP:0100678)3.16611936
37Insidious onset (HP:0003587)3.15306619
38Termporal pattern (HP:0011008)3.15306619
39Dysmetria (HP:0001310)3.05294281
40Follicular hyperkeratosis (HP:0007502)3.01297080
41Protruding tongue (HP:0010808)2.93587277
42Inability to walk (HP:0002540)2.89611101
43Type II lissencephaly (HP:0007260)2.89428942
44Abnormal auditory evoked potentials (HP:0006958)2.87802410
45Abnormality of the renal cortex (HP:0011035)2.87335535
46Progressive cerebellar ataxia (HP:0002073)2.85316385
47Congenital ichthyosiform erythroderma (HP:0007431)2.84515506
48Slow saccadic eye movements (HP:0000514)2.80234547
49Cystic liver disease (HP:0006706)2.78870489
50Attenuation of retinal blood vessels (HP:0007843)2.78494054
51Abolished electroretinogram (ERG) (HP:0000550)2.75721820
52Anteriorly placed anus (HP:0001545)2.72267799
53Coronal craniosynostosis (HP:0004440)2.71687679
54Spastic paraparesis (HP:0002313)2.70703022
55Decreased central vision (HP:0007663)2.66721553
56Chronic hepatic failure (HP:0100626)2.66099796
57Aplasia involving bones of the extremities (HP:0009825)2.62712444
58Aplasia involving bones of the upper limbs (HP:0009823)2.62712444
59Aplasia of the phalanges of the hand (HP:0009802)2.62712444
60Cerebral hemorrhage (HP:0001342)2.62013899
61Furrowed tongue (HP:0000221)2.61122726
62Scanning speech (HP:0002168)2.61011954
63Abnormality of glycolysis (HP:0004366)2.59038497
64Increased serum pyruvate (HP:0003542)2.59038497
65Stridor (HP:0010307)2.58267968
66Decreased lacrimation (HP:0000633)2.57094411
67Pendular nystagmus (HP:0012043)2.56319883
68Progressive inability to walk (HP:0002505)2.54262914
69Congenital hepatic fibrosis (HP:0002612)2.50793695
70Leukodystrophy (HP:0002415)2.50593084
71Thickened helices (HP:0000391)2.49013144
72Infantile muscular hypotonia (HP:0008947)2.47848204
73Congenital sensorineural hearing impairment (HP:0008527)2.47000755
74Short hallux (HP:0010109)2.45753627
75Hemiparesis (HP:0001269)2.45391565
76Chorioretinal atrophy (HP:0000533)2.44991363
77Abnormal drinking behavior (HP:0030082)2.44685044
78Polydipsia (HP:0001959)2.44685044
79Increased circulating renin level (HP:0000848)2.44591053
80Decreased circulating renin level (HP:0003351)2.42279305
81Hypoplastic pelvis (HP:0008839)2.39793498
82Cupped ear (HP:0000378)2.37276877
83Retinal dysplasia (HP:0007973)2.36925394
84Split foot (HP:0001839)2.36807294
85Absent septum pellucidum (HP:0001331)2.36760187
86Gaze-evoked nystagmus (HP:0000640)2.35809756
87Autoamputation (HP:0001218)2.32616464
88Adrenal hypoplasia (HP:0000835)2.32149199
89Focal seizures (HP:0007359)2.32053898
90Ulnar claw (HP:0001178)2.29652973
91Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.29254882
92Synostosis involving the elbow (HP:0003938)2.27676953
93Humeroradial synostosis (HP:0003041)2.27676953
94Prominent supraorbital ridges (HP:0000336)2.26864755
95Sclerocornea (HP:0000647)2.25915522
96Male pseudohermaphroditism (HP:0000037)2.25618808
97Broad-based gait (HP:0002136)2.25284001
98Aplasia/Hypoplasia of the hallux (HP:0008362)2.24496096
99Esophageal atresia (HP:0002032)2.24207221
100Increased neuronal autofluorescent lipopigment (HP:0002074)2.22927148
101Hypoplasia of the iris (HP:0007676)2.21394426
102Small epiphyses (HP:0010585)2.21301330
103Decreased electroretinogram (ERG) amplitude (HP:0000654)2.20881661
104Partial agenesis of the corpus callosum (HP:0001338)2.20766140
105Premature rupture of membranes (HP:0001788)2.20112268
106Medial flaring of the eyebrow (HP:0010747)2.19900904
107Patellar aplasia (HP:0006443)2.19384103
108Clumsiness (HP:0002312)2.19315660
109Muscle fiber splitting (HP:0003555)2.17890598
110Hypoplastic ischia (HP:0003175)2.17096919
111Abnormality of the phalanges of the 2nd finger (HP:0009541)2.16979175
112Aplasia/Hypoplasia of the tongue (HP:0010295)2.14969767
113Atonic seizures (HP:0010819)2.14697241
114Ankle clonus (HP:0011448)2.14071381
115Concave nail (HP:0001598)2.13472559
116Breast hypoplasia (HP:0003187)2.12978464
117Bell-shaped thorax (HP:0001591)2.08266307
118White forelock (HP:0002211)2.08013853
119Mesangial abnormality (HP:0001966)2.06896791
120Febrile seizures (HP:0002373)2.06862769
121Aplasia/Hypoplasia of the patella (HP:0006498)2.06860856
122Tachypnea (HP:0002789)2.06150958
123Hypomagnesemia (HP:0002917)2.04737215
124Steppage gait (HP:0003376)2.04193722
125CNS hypomyelination (HP:0003429)2.03960033
126Patchy hypopigmentation of hair (HP:0011365)2.03523766
127Anomalous pulmonary venous return (HP:0010772)2.03333055
128Relative macrocephaly (HP:0004482)2.02986541
129Aplasia/Hypoplasia of the tibia (HP:0005772)2.02328734
130Morphological abnormality of the inner ear (HP:0011390)2.00988342
131Lower limb muscle weakness (HP:0007340)2.00342308
132Abnormality of the septum pellucidum (HP:0007375)1.99738616
133Polyuria (HP:0000103)1.99409848
134Myokymia (HP:0002411)1.99240949
135Pigmentary retinal degeneration (HP:0001146)1.99200570
136Hepatosplenomegaly (HP:0001433)1.98914890
137Chin dimple (HP:0010751)1.97782621
138Megalencephaly (HP:0001355)1.97682118
139Bulbous nose (HP:0000414)1.96868822
140Pheochromocytoma (HP:0002666)1.95270692
141Barrel-shaped chest (HP:0001552)1.95095925
142Anencephaly (HP:0002323)1.90740070
143Abnormal biliary tract physiology (HP:0012439)1.90199741
144Bile duct proliferation (HP:0001408)1.90199741
145Erythroderma (HP:0001019)1.89850431
146Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89509448
147Cerebellar dysplasia (HP:0007033)1.89348179
148Small hand (HP:0200055)1.87849546
149Absent/shortened dynein arms (HP:0200106)1.87720879
150Dynein arm defect of respiratory motile cilia (HP:0012255)1.87720879
151Abnormality of the middle phalanges of the toes (HP:0010183)1.86183409
152Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.85917982
153Fair hair (HP:0002286)1.85606787
154Abnormality of the ischium (HP:0003174)1.85570934
155Partial duplication of thumb phalanx (HP:0009944)1.84255650
156Abnormality of the pons (HP:0007361)1.84051478
157Tubulointerstitial fibrosis (HP:0005576)1.83625424
158Hypophosphatemic rickets (HP:0004912)1.83198084
159Segmental peripheral demyelination/remyelination (HP:0003481)1.82264756
160Occipital encephalocele (HP:0002085)1.81934819
161Diminished movement (HP:0002374)1.81785570
162Adactyly (HP:0009776)1.81170639
163Bowel incontinence (HP:0002607)1.81158895
164Hammertoe (HP:0001765)1.80382731
165Stomach cancer (HP:0012126)1.78705823
166Abnormality of the pulmonary veins (HP:0011718)1.78533270
167Metabolic alkalosis (HP:0200114)1.78375093
168Stage 5 chronic kidney disease (HP:0003774)1.78153757
169Round ear (HP:0100830)1.77615390
170Paraparesis (HP:0002385)1.77417572
171Bone cyst (HP:0012062)1.77143977
172Broad metatarsal (HP:0001783)1.76026081
173Long nose (HP:0003189)1.75207503
174Gait imbalance (HP:0002141)1.74972638
175Anterior segment dysgenesis (HP:0007700)1.74827169
176Optic nerve hypoplasia (HP:0000609)1.74668913
177Poor speech (HP:0002465)1.74459630
178Macular degeneration (HP:0000608)1.73789896
179Abnormal rod and cone electroretinograms (HP:0008323)1.73753439
180Decreased motor nerve conduction velocity (HP:0003431)1.73215609
181Methylmalonic acidemia (HP:0002912)1.73181714
182Action tremor (HP:0002345)1.73078496
183Neuroendocrine neoplasm (HP:0100634)1.72422679
184Morphological abnormality of the pyramidal tract (HP:0002062)1.72368391
185Global brain atrophy (HP:0002283)1.72081907
186Mixed hearing impairment (HP:0000410)1.71266223
187Septo-optic dysplasia (HP:0100842)1.71261529
188Gowers sign (HP:0003391)1.71260755
189Bronchomalacia (HP:0002780)1.70901564
190Lissencephaly (HP:0001339)1.70229157
191Abnormality of the parathyroid morphology (HP:0011766)1.69522345
192Conical tooth (HP:0000698)1.69479538
193Hemiplegia (HP:0002301)1.69439692
194Renal Fanconi syndrome (HP:0001994)1.69284621
195Ketoacidosis (HP:0001993)1.68034921
196Severe muscular hypotonia (HP:0006829)1.66950202

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.63989095
2INSRR5.73109144
3FRK5.58197348
4OXSR14.74792285
5EPHB13.94607855
6TNIK3.65459372
7ADRBK23.33140773
8ACVR1B3.26828012
9BCR2.93118300
10CDK192.72741762
11MET2.62530134
12WNK42.53808054
13GRK12.45284424
14ICK2.43001261
15PKN12.35276293
16PRPF4B2.24502162
17NEK62.13381820
18FGFR22.12848404
19PBK2.06679275
20WNK12.02720831
21UHMK11.81309083
22WNK31.75828842
23DAPK21.74808116
24CSNK1G31.73850840
25CSNK1A1L1.70311423
26TGFBR11.69823082
27ADRBK11.62926165
28MAP4K21.62194778
29LIMK11.56744891
30TAOK31.56575984
31NTRK11.54404166
32MAPKAPK51.54078996
33ROCK21.53833067
34FGR1.53122527
35PNCK1.49390171
36CAMKK21.45950495
37TLK11.45674520
38MST41.45581117
39ZAK1.41200449
40PAK61.40627075
41CSNK1G11.38637795
42PINK11.38056190
43TYRO31.35794670
44EPHA31.30662904
45CLK11.30120670
46CSNK1G21.26883199
47KIT1.22161822
48MKNK21.22109364
49CAMK2B1.19836046
50CASK1.16675616
51EPHA41.14921355
52NTRK31.14389244
53CAMK2D1.06977689
54PAK30.99941175
55PRKCG0.97313202
56AKT30.93899330
57NLK0.90829116
58CDK140.87386556
59MARK20.86067702
60IRAK20.86024132
61ERBB40.85114222
62PRKCQ0.84964934
63SGK2230.84222813
64SGK4940.84222813
65TESK20.82015244
66MAPKAPK30.79804015
67CDK50.75805799
68CAMK2G0.74463345
69CHUK0.74145040
70CDK150.73221495
71IKBKB0.72600667
72MAPK150.72492598
73PRKAA20.71468087
74MUSK0.70866508
75DYRK20.69728032
76CDK180.68100208
77MAP2K10.68065349
78CAMK2A0.67328571
79MAP3K40.67276959
80CAMK10.67152495
81CDK11A0.65845675
82DMPK0.64337079
83CAMK1D0.64215887
84MARK10.63730923
85FER0.63325053
86LATS20.62861710
87STK38L0.62470982
88DDR20.61402337
89TXK0.60335701
90FYN0.60214884
91MAP3K30.60189399
92IRAK10.59761141
93MAP2K60.59441113
94PDGFRB0.58878735
95PRKCE0.58845186
96STK30.57403758
97PRKD10.57401022
98MAPK130.56816781
99TEC0.56786633
100BMX0.56590932
101CAMKK10.55386530
102PDPK10.54960976
103FES0.52517583
104EPHB20.51743745
105MAP3K70.50195743
106ARAF0.48951755
107PLK20.48797249
108SGK20.48262282
109PTK2B0.48081968
110PIK3CG0.47216063
111ROCK10.46740802
112DYRK1A0.46602881
113CSK0.46149713
114MYLK0.43702089
115GSK3A0.42079138
116STK110.41929106
117CSNK1D0.41918552
118RPS6KA50.41440189
119BMPR1B0.41172838
120PRKG10.40597044
121CAMK1G0.40402936
122IGF1R0.40210922
123ERBB20.39872103
124FLT30.39720751
125TGFBR20.39016383
126RPS6KA60.38759599
127PAK10.37745780
128TRPM70.37066121
129INSR0.36563855
130PRKAA10.36487510
131MKNK10.35824249
132PRKCH0.34852097
133ABL20.34386286
134PRKCA0.33769946
135MELK0.33740194
136CSNK1A10.33082090
137MAP3K130.31679461
138NEK20.31665068
139GRK50.30876705
140MAPK40.30713031
141CAMK40.29628490
142BRSK20.29343863
143STK380.29036792
144PIK3CA0.28889703
145TIE10.28465906
146PHKG20.28313545
147PHKG10.28313545
148PRKACB0.26901576
149MOS0.26783015
150MAPK70.26379497
151NUAK10.24230193
152PAK20.24010338
153PTK20.23301264
154NTRK20.22754440
155PRKACA0.21926778
156ABL10.21920340
157SRC0.21142817
158MAP3K20.20865334
159ITK0.19884645
160OBSCN0.19844057

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.65085789
2Steroid biosynthesis_Homo sapiens_hsa001004.87656751
3Fatty acid elongation_Homo sapiens_hsa000624.23780762
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.67440985
5Ether lipid metabolism_Homo sapiens_hsa005653.11521222
6Nitrogen metabolism_Homo sapiens_hsa009102.73408615
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.64466042
8Axon guidance_Homo sapiens_hsa043602.48431666
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.46311577
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.16421012
11ABC transporters_Homo sapiens_hsa020101.99814236
12Sulfur metabolism_Homo sapiens_hsa009201.97156711
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.96330560
14Tryptophan metabolism_Homo sapiens_hsa003801.91126587
15Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.84093082
16Sphingolipid metabolism_Homo sapiens_hsa006001.83906707
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.77806018
18Protein export_Homo sapiens_hsa030601.74773377
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.66603162
20Taste transduction_Homo sapiens_hsa047421.58387346
21Selenocompound metabolism_Homo sapiens_hsa004501.58038146
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.53719352
23Olfactory transduction_Homo sapiens_hsa047401.50927066
24Oxidative phosphorylation_Homo sapiens_hsa001901.50599477
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.48703176
26Renal cell carcinoma_Homo sapiens_hsa052111.45713851
27Linoleic acid metabolism_Homo sapiens_hsa005911.42807333
28Calcium signaling pathway_Homo sapiens_hsa040201.36983002
29Butanoate metabolism_Homo sapiens_hsa006501.35105322
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.35031634
31Caffeine metabolism_Homo sapiens_hsa002321.33236253
32Serotonergic synapse_Homo sapiens_hsa047261.30973341
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.29100944
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.29066587
35Glutamatergic synapse_Homo sapiens_hsa047241.28220221
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26756250
37Chemical carcinogenesis_Homo sapiens_hsa052041.22262635
38GABAergic synapse_Homo sapiens_hsa047271.18136164
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17787932
40ECM-receptor interaction_Homo sapiens_hsa045121.17498402
41Tight junction_Homo sapiens_hsa045301.14754096
42Vitamin B6 metabolism_Homo sapiens_hsa007501.13811043
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.12194843
44Malaria_Homo sapiens_hsa051441.07224572
45Insulin secretion_Homo sapiens_hsa049111.06297814
46Long-term depression_Homo sapiens_hsa047301.03523935
47Alzheimers disease_Homo sapiens_hsa050101.03029863
48Vibrio cholerae infection_Homo sapiens_hsa051101.02860280
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99712834
50Arginine and proline metabolism_Homo sapiens_hsa003300.99595071
51Rheumatoid arthritis_Homo sapiens_hsa053230.98612533
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97337900
53Sphingolipid signaling pathway_Homo sapiens_hsa040710.96620151
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.96026299
55Ras signaling pathway_Homo sapiens_hsa040140.94297319
56Morphine addiction_Homo sapiens_hsa050320.94240084
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93558784
58Glycerolipid metabolism_Homo sapiens_hsa005610.91405201
59Endocytosis_Homo sapiens_hsa041440.90695059
60Histidine metabolism_Homo sapiens_hsa003400.88933128
61Parkinsons disease_Homo sapiens_hsa050120.87508119
62Collecting duct acid secretion_Homo sapiens_hsa049660.86987648
63Complement and coagulation cascades_Homo sapiens_hsa046100.86473652
64Dorso-ventral axis formation_Homo sapiens_hsa043200.86145234
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85643168
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82730219
67Ovarian steroidogenesis_Homo sapiens_hsa049130.81990808
68PPAR signaling pathway_Homo sapiens_hsa033200.81368167
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81365991
70Fat digestion and absorption_Homo sapiens_hsa049750.81340077
71ErbB signaling pathway_Homo sapiens_hsa040120.80814670
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80015669
73Retinol metabolism_Homo sapiens_hsa008300.78036970
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.76735251
75Vitamin digestion and absorption_Homo sapiens_hsa049770.76376626
76beta-Alanine metabolism_Homo sapiens_hsa004100.76336029
77Fatty acid metabolism_Homo sapiens_hsa012120.74968443
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74415329
79Circadian rhythm_Homo sapiens_hsa047100.74347563
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74046152
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73143613
82Arachidonic acid metabolism_Homo sapiens_hsa005900.71917775
83Cholinergic synapse_Homo sapiens_hsa047250.70030294
84Autoimmune thyroid disease_Homo sapiens_hsa053200.68544910
85Basal transcription factors_Homo sapiens_hsa030220.68494481
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67509849
87African trypanosomiasis_Homo sapiens_hsa051430.67058941
88Lysosome_Homo sapiens_hsa041420.65805734
89Cocaine addiction_Homo sapiens_hsa050300.64102323
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63394294
91TGF-beta signaling pathway_Homo sapiens_hsa043500.63299275
92Circadian entrainment_Homo sapiens_hsa047130.62244971
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62238720
94Glutathione metabolism_Homo sapiens_hsa004800.61808830
95Phagosome_Homo sapiens_hsa041450.61637196
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61218227
97Homologous recombination_Homo sapiens_hsa034400.60698914
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57653084
99Salivary secretion_Homo sapiens_hsa049700.57141420
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55589572
101Dopaminergic synapse_Homo sapiens_hsa047280.55371503
102Amphetamine addiction_Homo sapiens_hsa050310.53821422
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.52357114
104Focal adhesion_Homo sapiens_hsa045100.51845910
105Sulfur relay system_Homo sapiens_hsa041220.51355067
106Choline metabolism in cancer_Homo sapiens_hsa052310.51064448
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50875266
108Fatty acid biosynthesis_Homo sapiens_hsa000610.50723467
109Hedgehog signaling pathway_Homo sapiens_hsa043400.49749507
110Gap junction_Homo sapiens_hsa045400.49508870
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48514266
112Basal cell carcinoma_Homo sapiens_hsa052170.48391457
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47693281
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46198404
115Cardiac muscle contraction_Homo sapiens_hsa042600.45672862
116Pancreatic secretion_Homo sapiens_hsa049720.45538604
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43208963
118Phototransduction_Homo sapiens_hsa047440.42637052
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42405321
120MAPK signaling pathway_Homo sapiens_hsa040100.42377170
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.42275518
122TNF signaling pathway_Homo sapiens_hsa046680.41965256
123Nicotine addiction_Homo sapiens_hsa050330.41049581
124Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40044911
125Gastric acid secretion_Homo sapiens_hsa049710.39675523
126Melanoma_Homo sapiens_hsa052180.38182657
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37583026
128Synaptic vesicle cycle_Homo sapiens_hsa047210.36419800
129Salmonella infection_Homo sapiens_hsa051320.34324361
130cAMP signaling pathway_Homo sapiens_hsa040240.33297660
131Protein digestion and absorption_Homo sapiens_hsa049740.33228563
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32784172
133Huntingtons disease_Homo sapiens_hsa050160.32776829
134Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32651487
135Leukocyte transendothelial migration_Homo sapiens_hsa046700.32063349
136Peroxisome_Homo sapiens_hsa041460.31701943
137Dilated cardiomyopathy_Homo sapiens_hsa054140.31411411
138Chemokine signaling pathway_Homo sapiens_hsa040620.31187034
139Prion diseases_Homo sapiens_hsa050200.31097432
140Mineral absorption_Homo sapiens_hsa049780.29993606
141Renin secretion_Homo sapiens_hsa049240.29768954
142Oxytocin signaling pathway_Homo sapiens_hsa049210.29380797
143Prostate cancer_Homo sapiens_hsa052150.27950986
144Wnt signaling pathway_Homo sapiens_hsa043100.27423647
145Propanoate metabolism_Homo sapiens_hsa006400.26856378

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