ADAMTS5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)7.26158236
2collagen fibril organization (GO:0030199)6.53455409
3glomerular basement membrane development (GO:0032836)5.70642848
4chondrocyte proliferation (GO:0035988)5.54265050
5retina vasculature morphogenesis in camera-type eye (GO:0061299)5.11404305
6regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)5.03750376
7neuron projection extension involved in neuron projection guidance (GO:1902284)4.96948249
8axon extension involved in axon guidance (GO:0048846)4.96948249
9regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.71823407
10sequestering of extracellular ligand from receptor (GO:0035581)4.70953285
11bone trabecula formation (GO:0060346)4.64514412
12negative regulation of muscle hypertrophy (GO:0014741)4.58487002
13prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.36535025
14lung lobe morphogenesis (GO:0060463)4.31952969
15regulation of muscle hypertrophy (GO:0014743)4.21017116
16collagen metabolic process (GO:0032963)4.20430194
17glomerular visceral epithelial cell development (GO:0072015)4.14640066
18vascular endothelial growth factor signaling pathway (GO:0038084)4.12766792
19collagen catabolic process (GO:0030574)4.10805571
20metanephric mesenchyme development (GO:0072075)4.09405723
21multicellular organismal macromolecule metabolic process (GO:0044259)4.07665540
22low-density lipoprotein particle clearance (GO:0034383)4.05718585
23mesenchymal-epithelial cell signaling (GO:0060638)4.05621717
24endodermal cell differentiation (GO:0035987)4.05273560
25lung vasculature development (GO:0060426)4.02981754
26basement membrane organization (GO:0071711)3.99751743
27positive regulation of endothelial cell apoptotic process (GO:2000353)3.98820690
28negative regulation of cardiac muscle tissue growth (GO:0055022)3.92984248
29negative regulation of heart growth (GO:0061117)3.92984248
30multicellular organismal metabolic process (GO:0044236)3.91869675
31organ induction (GO:0001759)3.87472030
32kidney mesenchyme development (GO:0072074)3.86824721
33regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.86624897
34skin morphogenesis (GO:0043589)3.86091230
35response to gravity (GO:0009629)3.84908579
36dermatan sulfate biosynthetic process (GO:0030208)3.84873258
37regulation of cardiac muscle hypertrophy (GO:0010611)3.82324923
38multicellular organismal catabolic process (GO:0044243)3.81776592
39cellular response to vitamin (GO:0071295)3.80548198
40glomerular filtration (GO:0003094)3.78275119
41extracellular fibril organization (GO:0043206)3.75247498
42glomerular epithelial cell development (GO:0072310)3.69598430
43regulation of cardiac muscle cell differentiation (GO:2000725)3.68208023
44renal filtration (GO:0097205)3.65947366
45negative regulation of chondrocyte differentiation (GO:0032331)3.64491438
46apoptotic cell clearance (GO:0043277)3.63622646
47negative regulation of cardiac muscle hypertrophy (GO:0010614)3.50872877
48dermatan sulfate metabolic process (GO:0030205)3.50725475
49negative regulation of gluconeogenesis (GO:0045721)3.50179740
50negative regulation of fatty acid transport (GO:2000192)3.48264849
51barbed-end actin filament capping (GO:0051016)3.46760909
52negative regulation of nitric-oxide synthase activity (GO:0051001)3.46531886
53ovulation from ovarian follicle (GO:0001542)3.45265663
54negative regulation of cartilage development (GO:0061037)3.43796048
55fibril organization (GO:0097435)3.39933932
56lymphangiogenesis (GO:0001946)3.39132487
57cell adhesion mediated by integrin (GO:0033627)3.37990938
58positive regulation of fatty acid oxidation (GO:0046321)3.37725674
59extracellular matrix assembly (GO:0085029)3.36698688
60insulin-like growth factor receptor signaling pathway (GO:0048009)3.36237956
61lymph vessel development (GO:0001945)3.35716757
62* extracellular matrix disassembly (GO:0022617)3.34827661
63negative regulation of protein localization to cell surface (GO:2000009)3.34786697
64negative regulation of cardiac muscle tissue development (GO:0055026)3.33060842
65epoxygenase P450 pathway (GO:0019373)3.31452939
66smooth muscle tissue development (GO:0048745)3.29643492
67regulation of integrin-mediated signaling pathway (GO:2001044)3.29429682
68chondroitin sulfate catabolic process (GO:0030207)3.26302485
69keratan sulfate catabolic process (GO:0042340)3.26076051
70positive regulation of fatty acid beta-oxidation (GO:0032000)3.26042966
71white fat cell differentiation (GO:0050872)3.24347249
72exocrine pancreas development (GO:0031017)3.23872932
73positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.23067859
74negative regulation of nitric oxide biosynthetic process (GO:0045019)3.17948694
75embryonic cranial skeleton morphogenesis (GO:0048701)3.17405998
76branching involved in prostate gland morphogenesis (GO:0060442)3.17017472
77protein localization to cell surface (GO:0034394)3.15269035
78regulation of chondrocyte differentiation (GO:0032330)3.14720171
79negative regulation of androgen receptor signaling pathway (GO:0060766)3.13157819
80type B pancreatic cell proliferation (GO:0044342)3.12284505
81negative regulation of BMP signaling pathway (GO:0030514)3.12280185
82blood vessel maturation (GO:0001955)3.11562684
83endothelial cell morphogenesis (GO:0001886)3.10425857
84cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.10357211
85wound healing, spreading of epidermal cells (GO:0035313)3.10166854
86cardiac epithelial to mesenchymal transition (GO:0060317)3.09033449
87positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.06221127
88positive regulation of extracellular matrix organization (GO:1903055)3.06208928
89positive regulation of cardiac muscle hypertrophy (GO:0010613)3.06127289
90positive regulation of muscle hypertrophy (GO:0014742)3.06127289
91regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.05585827
92regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.05366091
93cell migration involved in sprouting angiogenesis (GO:0002042)3.05110173
94chondrocyte development (GO:0002063)3.04058019
95extracellular negative regulation of signal transduction (GO:1900116)3.02457118
96extracellular regulation of signal transduction (GO:1900115)3.02457118
97cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.02225311
98craniofacial suture morphogenesis (GO:0097094)3.00756240
99regulation of organ formation (GO:0003156)2.98838401
100regulation of cartilage development (GO:0061035)2.98360201
101epithelial cell-cell adhesion (GO:0090136)2.96079655
102regulation of muscle adaptation (GO:0043502)2.94439874
103* extracellular matrix organization (GO:0030198)2.94404278
104* extracellular structure organization (GO:0043062)2.93218960
105positive regulation of glycolytic process (GO:0045821)2.90876346
106hippo signaling (GO:0035329)2.90195857
107membrane raft organization (GO:0031579)2.88970381
108regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.88885763
109cell proliferation involved in metanephros development (GO:0072203)2.86473770
110cell migration involved in heart development (GO:0060973)2.85173681
111plasma membrane repair (GO:0001778)2.83495367
112lung secretory cell differentiation (GO:0061140)2.83159685
113blood vessel remodeling (GO:0001974)2.82395429
114negative regulation of smooth muscle cell migration (GO:0014912)2.81772697
115peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.81230101
116regulation of tight junction assembly (GO:2000810)2.81219348
117negative regulation of catenin import into nucleus (GO:0035414)2.80349023
118regulation of transforming growth factor beta2 production (GO:0032909)2.78595805
119protein retention in ER lumen (GO:0006621)2.77853005
120omega-hydroxylase P450 pathway (GO:0097267)2.77552900
121vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.76610398
122platelet-derived growth factor receptor signaling pathway (GO:0048008)2.75664397
123positive regulation of smooth muscle cell migration (GO:0014911)2.74856751
124mammary gland development (GO:0030879)2.74520934
125substrate adhesion-dependent cell spreading (GO:0034446)2.73555923
126stress fiber assembly (GO:0043149)2.73353311
127peptide cross-linking (GO:0018149)2.72738012
128fibroblast migration (GO:0010761)2.71622124
129planar cell polarity pathway involved in neural tube closure (GO:0090179)2.67545948
130regulation of sequestering of triglyceride (GO:0010889)2.67384345
131negative regulation of leukocyte chemotaxis (GO:0002689)2.65346742
132pattern specification involved in kidney development (GO:0061004)2.65213688
133substrate-dependent cell migration (GO:0006929)2.65097540
134regulation of smooth muscle cell migration (GO:0014910)2.64951731
135positive regulation of glycogen biosynthetic process (GO:0045725)2.64272447
136iron ion import (GO:0097286)2.64064389
137regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.63976832
138growth hormone receptor signaling pathway (GO:0060396)2.63966605
139middle ear morphogenesis (GO:0042474)2.63096430
140positive regulation of blood vessel endothelial cell migration (GO:0043536)2.62797793
141glomerulus development (GO:0032835)2.62764633
142virion attachment to host cell (GO:0019062)2.62563100
143adhesion of symbiont to host cell (GO:0044650)2.62563100
144regulation of cardiac muscle tissue growth (GO:0055021)2.62207216
145muscle cell cellular homeostasis (GO:0046716)2.61982533
146positive regulation of mesenchymal cell proliferation (GO:0002053)2.61549058
147pathway-restricted SMAD protein phosphorylation (GO:0060389)2.61409967
148regulation of gastrulation (GO:0010470)2.60532556
149gonadal mesoderm development (GO:0007506)2.60253160
150cell proliferation involved in kidney development (GO:0072111)2.59876576
151brown fat cell differentiation (GO:0050873)2.57612481
152positive regulation of epithelial to mesenchymal transition (GO:0010718)2.57197478
153outer ear morphogenesis (GO:0042473)2.57043236
154cellular response to interferon-alpha (GO:0035457)2.56715683
155trabecula formation (GO:0060343)2.55748532

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.58246084
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.94690075
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.28750083
4CLOCK_20551151_ChIP-Seq_293T_Human3.66616971
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.59405898
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.54450871
7* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.83455967
8* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.75220786
9TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.70820039
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.65961684
11CJUN_26792858_Chip-Seq_BT549_Human2.63501473
12CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.56612242
13WT1_19549856_ChIP-ChIP_CCG9911_Human2.56070059
14* EP300_21415370_ChIP-Seq_HL-1_Mouse2.43976782
15RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.42119379
16NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.14550346
17NRF2_20460467_ChIP-Seq_MEFs_Mouse2.14550346
18ESR1_21235772_ChIP-Seq_MCF-7_Human2.06623405
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.00531214
20BRD4_25478319_ChIP-Seq_HGPS_Human1.99424257
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.92878305
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.85314947
23EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.83183419
24PPAR_26484153_Chip-Seq_NCI-H1993_Human1.82703453
25WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.81641691
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.81138327
27* EED_16625203_ChIP-ChIP_MESCs_Mouse1.77222771
28* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73934819
29* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.73425245
30* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.73425245
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69868722
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.60801152
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.58478371
34PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.57216497
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55290951
36* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.55270677
37* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.55046787
38* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.49388752
39* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.48330741
40TP53_18474530_ChIP-ChIP_U2OS_Human1.46798918
41SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.46403118
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46361835
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44423075
44* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44341009
45TP53_16413492_ChIP-PET_HCT116_Human1.43632111
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.43458370
47SOX9_24532713_ChIP-Seq_HFSC_Mouse1.41589651
48PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.39251205
49NFIB_24661679_ChIP-Seq_LUNG_Mouse1.38702540
50TBX20_22080862_ChIP-Seq_HEART_Mouse1.37427597
51TBX20_22328084_ChIP-Seq_HEART_Mouse1.37427597
52SOX2_20726797_ChIP-Seq_SW620_Human1.36100933
53SMC1_22415368_ChIP-Seq_MEFs_Mouse1.34529447
54* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34388666
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33256884
56SALL4_18804426_ChIP-ChIP_XEN_Mouse1.31734791
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.29872965
58HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.29611191
59* TP53_20018659_ChIP-ChIP_R1E_Mouse1.29507395
60SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.29288817
61SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.29288817
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29242748
63JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25977832
64CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.22925020
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21822727
66JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21652694
67* PIAS1_25552417_ChIP-Seq_VCAP_Human1.21441942
68SMAD4_21799915_ChIP-Seq_A2780_Human1.20911550
69* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.20815335
70* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20639681
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.19337715
72TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.17870425
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17573233
74FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.17097121
75FOXO3_23340844_ChIP-Seq_DLD1_Human1.14856693
76* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.13419844
77* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13176070
78ISL1_27105846_Chip-Seq_CPCs_Mouse1.11014347
79* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09856630
80ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.09716641
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09467478
82NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.08157270
83ESR1_20079471_ChIP-ChIP_T-47D_Human1.07450350
84KDM2B_26808549_Chip-Seq_REH_Human1.07093841
85SA1_22415368_ChIP-Seq_MEFs_Mouse1.06769997
86UBF1/2_26484160_Chip-Seq_HMECs_Human1.06441292
87* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.06202547
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.04526800
89SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.04335318
90TCF4_18268006_ChIP-ChIP_LS174T_Human1.04149433
91* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02882742
92AHR_22903824_ChIP-Seq_MCF-7_Human1.02133897
93GBX2_23144817_ChIP-Seq_PC3_Human1.01929127
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01853660
95AR_21572438_ChIP-Seq_LNCaP_Human1.01125963
96WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00674923
97TBX3_20139965_ChIP-Seq_MESCs_Mouse1.00272271
98TP53_23651856_ChIP-Seq_MEFs_Mouse1.00245992
99TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00134396
100CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99820485
101TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99726582
102TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99074787
103PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99048756
104SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98307532
105TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97900176
106SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97755836
107RXR_22108803_ChIP-Seq_LS180_Human0.96819234
108* JARID2_20064375_ChIP-Seq_MESCs_Mouse0.95816358
109* EZH2_27304074_Chip-Seq_ESCs_Mouse0.94661929
110Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93161208
111BCAT_22108803_ChIP-Seq_LS180_Human0.93044011
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92979136
113SMC3_22415368_ChIP-Seq_MEFs_Mouse0.92977676
114PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92349296
115NANOG_18555785_Chip-Seq_ESCs_Mouse0.88920039
116SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88506417
117RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87292751
118DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87268499
119NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86846382
120ARNT_22903824_ChIP-Seq_MCF-7_Human0.85731503
121TP63_23658742_ChIP-Seq_EP156T_Human0.85144532
122RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.84407120
123STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83262631

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.95475420
2MP0005275_abnormal_skin_tensile5.64291403
3MP0005503_abnormal_tendon_morphology4.91572769
4MP0003705_abnormal_hypodermis_morpholog3.94025494
5MP0004272_abnormal_basement_membrane3.50313885
6MP0003279_aneurysm3.36643462
7MP0001958_emphysema3.30651519
8MP0009384_cardiac_valve_regurgitation2.78447921
9MP0000013_abnormal_adipose_tissue2.53151497
10MP0005623_abnormal_meninges_morphology2.41546541
11MP0005670_abnormal_white_adipose2.32180695
12MP0006054_spinal_hemorrhage2.02983564
13MP0010368_abnormal_lymphatic_system2.01882120
14MP0005508_abnormal_skeleton_morphology1.96641406
15MP0002295_abnormal_pulmonary_circulatio1.93694416
16MP0002060_abnormal_skin_morphology1.92781923
17MP0005666_abnormal_adipose_tissue1.81471988
18MP0002837_dystrophic_cardiac_calcinosis1.79110183
19MP0002108_abnormal_muscle_morphology1.78014119
20MP0005375_adipose_tissue_phenotype1.72618241
21MP0001879_abnormal_lymphatic_vessel1.70720925
22MP0000003_abnormal_adipose_tissue1.70302118
23MP0004185_abnormal_adipocyte_glucose1.70095101
24MP0004130_abnormal_muscle_cell1.68294048
25MP0003566_abnormal_cell_adhesion1.65271552
26MP0005257_abnormal_intraocular_pressure1.56420477
27MP0010386_abnormal_urinary_bladder1.47615901
28MP0003385_abnormal_body_wall1.43270283
29MP0000751_myopathy1.41935135
30MP0003091_abnormal_cell_migration1.40819733
31MP0009250_abnormal_appendicular_skeleto1.37499198
32MP0003045_fibrosis1.31332524
33MP0003724_increased_susceptibility_to1.28565406
34MP0002896_abnormal_bone_mineralization1.28129996
35MP0005023_abnormal_wound_healing1.26405043
36MP0004145_abnormal_muscle_electrophysio1.25228195
37MP0000767_abnormal_smooth_muscle1.20763181
38MP0003941_abnormal_skin_development1.18986434
39MP0002168_other_aberrant_phenotype1.18175779
40MP0004134_abnormal_chest_morphology1.17634647
41MP0001299_abnormal_eye_distance/1.14274322
42MP0001243_abnormal_dermal_layer1.14141191
43MP0000733_abnormal_muscle_development1.13400201
44MP0001542_abnormal_bone_strength1.09226669
45MP0003283_abnormal_digestive_organ1.09156479
46* MP0005390_skeleton_phenotype1.08925345
47MP0003942_abnormal_urinary_system1.07427333
48MP0002282_abnormal_trachea_morphology1.06786791
49* MP0000163_abnormal_cartilage_morphology1.05881542
50MP0002115_abnormal_skeleton_extremities1.05573602
51MP0000750_abnormal_muscle_regeneration1.02833359
52MP0009780_abnormal_chondrocyte_physiolo1.01242630
53MP0010030_abnormal_orbit_morphology1.01117337
54MP0005595_abnormal_vascular_smooth0.98812294
55MP0005171_absent_coat_pigmentation0.97534397
56MP0001661_extended_life_span0.97100379
57MP0002998_abnormal_bone_remodeling0.93606294
58MP0009115_abnormal_fat_cell0.93498431
59MP0000534_abnormal_ureter_morphology0.93199707
60MP0002254_reproductive_system_inflammat0.90973488
61MP0010352_gastrointestinal_tract_polyps0.90628302
62MP0003115_abnormal_respiratory_system0.90287876
63MP0003448_altered_tumor_morphology0.89788347
64MP0003828_pulmonary_edema0.88862400
65MP0003300_gastrointestinal_ulcer0.87988710
66MP0000538_abnormal_urinary_bladder0.87385604
67MP0006138_congestive_heart_failure0.87069178
68MP0002113_abnormal_skeleton_development0.86666106
69* MP0002933_joint_inflammation0.85878923
70MP0000759_abnormal_skeletal_muscle0.85654732
71MP0002249_abnormal_larynx_morphology0.85195995
72MP0005388_respiratory_system_phenotype0.85058600
73MP0002133_abnormal_respiratory_system0.85058600
74MP0002128_abnormal_blood_circulation0.84824832
75MP0002932_abnormal_joint_morphology0.84508487
76MP0000747_muscle_weakness0.84438987
77MP0000762_abnormal_tongue_morphology0.84284520
78MP0000428_abnormal_craniofacial_morphol0.82147174
79MP0009053_abnormal_anal_canal0.81487726
80MP0003959_abnormal_lean_body0.80885206
81MP0004084_abnormal_cardiac_muscle0.78010616
82MP0004036_abnormal_muscle_relaxation0.77442237
83MP0004233_abnormal_muscle_weight0.76991651
84MP0001614_abnormal_blood_vessel0.74815723
85MP0005076_abnormal_cell_differentiation0.73813200
86MP0004087_abnormal_muscle_fiber0.73412246
87MP0005164_abnormal_response_to0.72850964
88MP0000749_muscle_degeneration0.72737835
89* MP0001533_abnormal_skeleton_physiology0.72204652
90MP0002971_abnormal_brown_adipose0.71801482
91MP0002234_abnormal_pharynx_morphology0.71695348
92MP0001177_atelectasis0.71377840
93MP0004858_abnormal_nervous_system0.70760992
94MP0000432_abnormal_head_morphology0.68047161
95MP0005197_abnormal_uvea_morphology0.67875601
96MP0000462_abnormal_digestive_system0.67332924
97MP0000343_altered_response_to0.66039938
98MP0003950_abnormal_plasma_membrane0.64130201
99MP0002269_muscular_atrophy0.63189367
100MP0002089_abnormal_postnatal_growth/wei0.63152683
101MP0008775_abnormal_heart_ventricle0.62985971
102MP0004883_abnormal_blood_vessel0.62557585
103MP0002114_abnormal_axial_skeleton0.61671461
104MP0001175_abnormal_lung_morphology0.61458908
105MP0002106_abnormal_muscle_physiology0.61215482
106MP0003795_abnormal_bone_structure0.61136360
107MP0000049_abnormal_middle_ear0.60717856
108MP0005620_abnormal_muscle_contractility0.60308695
109MP0003191_abnormal_cellular_cholesterol0.59819407
110MP0009379_abnormal_foot_pigmentation0.59752445
111MP0001544_abnormal_cardiovascular_syste0.59490889
112MP0005385_cardiovascular_system_phenoty0.59490889
113MP0001881_abnormal_mammary_gland0.59363218
114MP0005367_renal/urinary_system_phenotyp0.59127917
115MP0000516_abnormal_urinary_system0.59127917
116MP0001348_abnormal_lacrimal_gland0.58922623
117MP0002166_altered_tumor_susceptibility0.58443934
118MP0003755_abnormal_palate_morphology0.58059368
119MP0005369_muscle_phenotype0.57590203
120MP0000230_abnormal_systemic_arterial0.56098902
121MP0002233_abnormal_nose_morphology0.53044998
122MP0003935_abnormal_craniofacial_develop0.51904531
123MP0002116_abnormal_craniofacial_bone0.51693736
124MP0000467_abnormal_esophagus_morphology0.50292903
125MP0001849_ear_inflammation0.48890195
126MP0001270_distended_abdomen0.47256762
127* MP0002109_abnormal_limb_morphology0.46851389

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.95614388
2Premature rupture of membranes (HP:0001788)7.95173621
3Aortic dissection (HP:0002647)5.38894136
4Ankle contracture (HP:0006466)5.35651180
5Broad metatarsal (HP:0001783)5.15396241
6Aortic aneurysm (HP:0004942)4.98042454
7Soft skin (HP:0000977)4.97956134
8Shallow orbits (HP:0000586)4.75134147
9Cervical subluxation (HP:0003308)4.32920398
10Cerebral aneurysm (HP:0004944)4.29148648
11Dilatation of the ascending aorta (HP:0005111)4.18120854
12Peritonitis (HP:0002586)4.12410916
13Atrophic scars (HP:0001075)4.07197211
14Bladder diverticulum (HP:0000015)3.97434429
15Popliteal pterygium (HP:0009756)3.91099350
16Wrist flexion contracture (HP:0001239)3.78543405
17Fragile skin (HP:0001030)3.73180035
18Vertebral compression fractures (HP:0002953)3.70113999
19Follicular hyperkeratosis (HP:0007502)3.67400081
20Type 2 muscle fiber atrophy (HP:0003554)3.62415069
21Abnormality of dentin (HP:0010299)3.61583354
22Increased connective tissue (HP:0009025)3.59288322
23Mitral valve prolapse (HP:0001634)3.52456500
24Vascular tortuosity (HP:0004948)3.46874948
25Type 1 muscle fiber predominance (HP:0003803)3.43330421
26Spinal rigidity (HP:0003306)3.42476296
27Wormian bones (HP:0002645)3.40700706
28Neonatal short-limb short stature (HP:0008921)3.34946793
29Biconcave vertebral bodies (HP:0004586)3.33716570
30Genu recurvatum (HP:0002816)3.33640081
31Blue sclerae (HP:0000592)3.29158544
32Overgrowth (HP:0001548)3.23790625
33Muscle fiber atrophy (HP:0100295)3.15605397
34Abnormality of the neuromuscular junction (HP:0003398)3.01734944
35Fatigable weakness (HP:0003473)3.01734944
36Hyperextensible skin (HP:0000974)2.88634194
37Increased variability in muscle fiber diameter (HP:0003557)2.87851106
38Mitral stenosis (HP:0001718)2.84317589
39Arterial tortuosity (HP:0005116)2.79860660
40Aneurysm (HP:0002617)2.79363110
41Bowel diverticulosis (HP:0005222)2.73498640
42Ovoid vertebral bodies (HP:0003300)2.68082783
43Slender build (HP:0001533)2.66147928
44Aortic valve stenosis (HP:0001650)2.65155705
45Joint laxity (HP:0001388)2.60665613
46Ectopia lentis (HP:0001083)2.58787869
47Bell-shaped thorax (HP:0001591)2.55823626
48Gowers sign (HP:0003391)2.54138729
49Abnormal delivery (HP:0001787)2.53877947
50Infantile muscular hypotonia (HP:0008947)2.47858847
51Abnormality of the acetabulum (HP:0003170)2.47661038
52Abnormality of skeletal muscle fiber size (HP:0012084)2.47517881
53Venous abnormality (HP:0002624)2.46927488
54Thin bony cortex (HP:0002753)2.44697267
55Wide anterior fontanel (HP:0000260)2.42941051
56Buphthalmos (HP:0000557)2.42751777
57Venous insufficiency (HP:0005293)2.41597543
58Decreased muscle mass (HP:0003199)2.41420820
59Hypoplastic ischia (HP:0003175)2.40566980
60Keratoconus (HP:0000563)2.39523153
61Increased corneal curvature (HP:0100692)2.39523153
62Elbow flexion contracture (HP:0002987)2.38228502
63Weak cry (HP:0001612)2.35276014
64Nonimmune hydrops fetalis (HP:0001790)2.33635910
65Mildly elevated creatine phosphokinase (HP:0008180)2.33138515
66Hypoplasia of the iris (HP:0007676)2.32479836
67Camptodactyly of toe (HP:0001836)2.31565269
68Mitral regurgitation (HP:0001653)2.30516840
69Muscle fiber splitting (HP:0003555)2.30324493
70Acanthosis nigricans (HP:0000956)2.26632188
71Easy fatigability (HP:0003388)2.26363901
72Striae distensae (HP:0001065)2.25931801
73Amniotic constriction ring (HP:0009775)2.24940798
74Abnormality of placental membranes (HP:0011409)2.24940798
75Osteolytic defects of the hand bones (HP:0009699)2.24812985
76Osteolytic defects of the phalanges of the hand (HP:0009771)2.24812985
77Round ear (HP:0100830)2.22645179
78Broad ribs (HP:0000885)2.20996601
79Osteoarthritis (HP:0002758)2.20354246
80Aplasia of the musculature (HP:0100854)2.19997602
81Syringomyelia (HP:0003396)2.19610275
82Spinal cord lesions (HP:0100561)2.19610275
83Knee flexion contracture (HP:0006380)2.19176513
84Abnormality of the ischium (HP:0003174)2.18883338
85Spondylolisthesis (HP:0003302)2.18250795
86Abnormality of the anterior chamber (HP:0000593)2.13526532
87Pterygium (HP:0001059)2.09496329
88Absent phalangeal crease (HP:0006109)2.07864333
89Microglossia (HP:0000171)2.06225489
90Coxa vara (HP:0002812)2.04471035
91Hip contracture (HP:0003273)2.03163415
92Abnormal finger flexion creases (HP:0006143)2.00789401
93Mesangial abnormality (HP:0001966)1.99801415
94Abnormality of the peritoneum (HP:0002585)1.98614685
95Oligomenorrhea (HP:0000876)1.97516276
96Cardiovascular calcification (HP:0011915)1.96826976
97Osteopenia (HP:0000938)1.96761342
98Thin ribs (HP:0000883)1.96423924
99Nemaline bodies (HP:0003798)1.96232589
100Lymphangioma (HP:0100764)1.94607000
101Inguinal hernia (HP:0000023)1.94038463
102Tibial bowing (HP:0002982)1.92535881
103Breech presentation (HP:0001623)1.92451142
104Congenital glaucoma (HP:0001087)1.91713420
105Mesomelia (HP:0003027)1.91133943
106Delayed closure of the anterior fontanelle (HP:0001476)1.90308529
107Corneal dystrophy (HP:0001131)1.89024942
108Short nail (HP:0001799)1.88889286
109Pulmonary artery stenosis (HP:0004415)1.87270999
110Aortic regurgitation (HP:0001659)1.86701714
111Mild short stature (HP:0003502)1.84986353
112Disproportionate tall stature (HP:0001519)1.84078884
113Deviation of the hallux (HP:0010051)1.83645085
114Coronal craniosynostosis (HP:0004440)1.80708650
115Scapular winging (HP:0003691)1.79381409
116Joint stiffness (HP:0001387)1.79021773
117Joint contractures involving the joints of the feet (HP:0100492)1.79009158
118Flexion contracture of toe (HP:0005830)1.79009158
119Thin skin (HP:0000963)1.78728363
120Difficulty running (HP:0009046)1.78368752
121Spinal cord compression (HP:0002176)1.78194113
122Asymmetry of the thorax (HP:0001555)1.77907636
123Flat cornea (HP:0007720)1.76852421
124Hallux valgus (HP:0001822)1.76418799
125Delayed gross motor development (HP:0002194)1.75829317
126Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.75643217
127Absent frontal sinuses (HP:0002688)1.74714606
128Limited hip movement (HP:0008800)1.72901170
129Hypoventilation (HP:0002791)1.71927929
130Broad long bones (HP:0005622)1.70666465
131Generalized amyotrophy (HP:0003700)1.70108965
132Platyspondyly (HP:0000926)1.70037762
133Protruding ear (HP:0000411)1.69035252
134Lipoatrophy (HP:0100578)1.68067640
135Decreased skull ossification (HP:0004331)1.66337351

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK9.38844698
2DDR25.04685037
3TRIB34.42635003
4SIK13.36022199
5TTN3.35078742
6PDGFRA3.33552435
7EPHB22.91368838
8LATS12.87478417
9CAMK1D2.79680164
10TGFBR22.62262470
11LATS22.50569723
12ERN12.44512988
13AKT32.35995686
14FER2.33152403
15RIPK12.12213717
16CAMK1G2.06553885
17KDR1.98990536
18TIE11.96645139
19PKN21.82226718
20FRK1.79622544
21PIK3CA1.77601040
22MYLK1.69808532
23EPHA31.66065508
24PAK21.60716375
25PTK2B1.43449659
26TRPM71.39189927
27NEK91.38606093
28DMPK1.34838917
29PTK61.20603187
30MAP3K121.20134539
31PDGFRB1.19663790
32JAK11.15598472
33TAF11.15422702
34FGFR31.15154818
35LMTK21.14531599
36ROCK11.14052459
37PAK31.11490934
38PDK41.09963995
39PDK31.09963995
40FGFR21.09666390
41STK31.03986644
42PTK21.03383589
43WNK40.98753905
44PAK40.97709497
45GRK50.96115629
46BMX0.95478737
47WNK10.94252631
48MTOR0.90155325
49MET0.89994125
50FGFR10.89636452
51PBK0.86054189
52EPHB10.84235176
53PAK60.83715178
54ERBB40.83598655
55MELK0.82491383
56MAP2K10.81691234
57PDK20.81381977
58PRKD20.81307375
59GRK70.78958677
60ILK0.78198627
61MAPK70.78147125
62TGFBR10.75867251
63LRRK20.75053489
64PRKD30.74416370
65STK380.74179714
66PRKCH0.73804022
67MAP3K60.72729332
68STK38L0.72609493
69PRKD10.71864074
70PRKAA20.69640435
71MAP3K30.67729851
72ERBB30.67636649
73CDK80.67025430
74RET0.66997304
75NUAK10.65699271
76MARK20.64973670
77MAP3K70.61647159
78INSR0.61594908
79MST1R0.61546105
80FGFR40.61429517
81MARK10.59606978
82ROCK20.58878742
83MOS0.57903054
84MAPKAPK50.57095870
85BCKDK0.56551290
86NTRK10.55920204
87CDK90.53853594
88PNCK0.52221161
89RPS6KA40.52173433
90LIMK10.51987246
91PIM20.51576833
92TYK20.51479247
93IGF1R0.51464485
94STK390.50969403
95KIT0.50476435
96SRC0.49885649
97GRK10.49137515
98MAPKAPK30.48337128
99ADRBK10.48239664
100PLK20.48031724
101ICK0.47080003
102CAMKK20.46968155
103SGK20.46647691
104ABL20.46593193
105OBSCN0.45022427
106NLK0.45003335
107CDK60.44457190
108GSK3A0.42016577
109SGK30.41185631
110PRKG20.41008069
111PHKG10.40249344
112PHKG20.40249344
113EIF2AK30.39332830
114PIK3CG0.39062001
115MAP3K100.38733067
116CAMK2G0.37921232
117PRKCE0.37649619
118JAK30.36742176
119FLT30.35407445
120IRAK10.32976846
121CAMK2D0.32946976
122CSK0.29780521
123RPS6KA20.28628678
124MAPK40.28563895
125RPS6KB10.27196280
126PRKG10.27136597
127CAMK2B0.26878458
128CAMK40.25665086
129SGK4940.24899776
130SGK2230.24899776
131EEF2K0.23897252
132TESK10.23114046
133MAPKAPK20.22962142
134CDC42BPA0.22043505
135ABL10.21714812
136MAPK10.21478442
137INSRR0.19939734
138DAPK30.18214353
139ZAK0.18050096

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.61777644
2Focal adhesion_Homo sapiens_hsa045103.21566556
3Regulation of lipolysis in adipocytes_Homo sapiens_hsa049233.12180304
4Protein digestion and absorption_Homo sapiens_hsa049742.73107833
5AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.36563157
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.31440588
7Amoebiasis_Homo sapiens_hsa051462.25851462
8Fatty acid biosynthesis_Homo sapiens_hsa000612.18412605
9Malaria_Homo sapiens_hsa051442.14146666
10Proteoglycans in cancer_Homo sapiens_hsa052052.07464551
11PPAR signaling pathway_Homo sapiens_hsa033201.99948631
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.97931476
13Dilated cardiomyopathy_Homo sapiens_hsa054141.96202479
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.90984954
15Small cell lung cancer_Homo sapiens_hsa052221.84658812
16TGF-beta signaling pathway_Homo sapiens_hsa043501.82022286
17Adherens junction_Homo sapiens_hsa045201.74243705
18PI3K-Akt signaling pathway_Homo sapiens_hsa041511.70143530
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.63023305
20Caffeine metabolism_Homo sapiens_hsa002321.55724279
21Melanoma_Homo sapiens_hsa052181.47340254
22Basal cell carcinoma_Homo sapiens_hsa052171.43098306
23Hippo signaling pathway_Homo sapiens_hsa043901.37210674
24AMPK signaling pathway_Homo sapiens_hsa041521.34521407
25Adipocytokine signaling pathway_Homo sapiens_hsa049201.32233453
26Propanoate metabolism_Homo sapiens_hsa006401.31325631
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.30609645
28Viral myocarditis_Homo sapiens_hsa054161.28604167
29Fatty acid metabolism_Homo sapiens_hsa012121.21941870
30Bladder cancer_Homo sapiens_hsa052191.21831947
31MicroRNAs in cancer_Homo sapiens_hsa052061.14968505
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.13725718
33Regulation of actin cytoskeleton_Homo sapiens_hsa048101.11815124
34Pathways in cancer_Homo sapiens_hsa052001.07596604
35Axon guidance_Homo sapiens_hsa043601.06399342
36Hedgehog signaling pathway_Homo sapiens_hsa043401.05582856
37Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04373067
38Platelet activation_Homo sapiens_hsa046111.03124292
39Rap1 signaling pathway_Homo sapiens_hsa040151.02427959
40Chronic myeloid leukemia_Homo sapiens_hsa052201.01631391
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00377859
42Insulin resistance_Homo sapiens_hsa049310.99736461
43Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94344527
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91187086
45Glioma_Homo sapiens_hsa052140.90568686
46Sulfur metabolism_Homo sapiens_hsa009200.90514722
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88974394
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88647130
49Toxoplasmosis_Homo sapiens_hsa051450.88014529
50ABC transporters_Homo sapiens_hsa020100.87603351
51Prostate cancer_Homo sapiens_hsa052150.87431756
52Pertussis_Homo sapiens_hsa051330.86779050
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86747798
54Tight junction_Homo sapiens_hsa045300.85756036
55Wnt signaling pathway_Homo sapiens_hsa043100.85217546
56Insulin signaling pathway_Homo sapiens_hsa049100.83729313
57Pancreatic cancer_Homo sapiens_hsa052120.80939313
58Glycerolipid metabolism_Homo sapiens_hsa005610.79668652
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79447865
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76855597
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75385789
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.74437517
63Ovarian steroidogenesis_Homo sapiens_hsa049130.73939469
64Circadian rhythm_Homo sapiens_hsa047100.72892629
65Long-term depression_Homo sapiens_hsa047300.72080761
66Renin-angiotensin system_Homo sapiens_hsa046140.71171297
67Dorso-ventral axis formation_Homo sapiens_hsa043200.67322086
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.66851654
69Melanogenesis_Homo sapiens_hsa049160.66721746
70Fatty acid degradation_Homo sapiens_hsa000710.66577469
71HIF-1 signaling pathway_Homo sapiens_hsa040660.66406758
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65716368
73mTOR signaling pathway_Homo sapiens_hsa041500.64013478
74Phagosome_Homo sapiens_hsa041450.61982817
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61887029
76Ras signaling pathway_Homo sapiens_hsa040140.61870773
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.61126446
78HTLV-I infection_Homo sapiens_hsa051660.60963413
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60679374
80TNF signaling pathway_Homo sapiens_hsa046680.58618734
81Renin secretion_Homo sapiens_hsa049240.57228592
82N-Glycan biosynthesis_Homo sapiens_hsa005100.56536654
83MAPK signaling pathway_Homo sapiens_hsa040100.56056570
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54893026
85Calcium signaling pathway_Homo sapiens_hsa040200.54810572
86Renal cell carcinoma_Homo sapiens_hsa052110.51852533
87Shigellosis_Homo sapiens_hsa051310.51586723
88Complement and coagulation cascades_Homo sapiens_hsa046100.51395276
89Endocytosis_Homo sapiens_hsa041440.51363193
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.50399788
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49202185
92Oxytocin signaling pathway_Homo sapiens_hsa049210.49102865
93Gap junction_Homo sapiens_hsa045400.48726283
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47988751
95Notch signaling pathway_Homo sapiens_hsa043300.46210087
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46204073
97Lysosome_Homo sapiens_hsa041420.45560937
98Cocaine addiction_Homo sapiens_hsa050300.45070029
99Selenocompound metabolism_Homo sapiens_hsa004500.44959509
100Colorectal cancer_Homo sapiens_hsa052100.44188696
101Thyroid hormone synthesis_Homo sapiens_hsa049180.44044102
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43524583
103Pyruvate metabolism_Homo sapiens_hsa006200.42254331
104FoxO signaling pathway_Homo sapiens_hsa040680.42120973
105Endometrial cancer_Homo sapiens_hsa052130.41760621
106Glucagon signaling pathway_Homo sapiens_hsa049220.41183384
107Prion diseases_Homo sapiens_hsa050200.40443656
108Estrogen signaling pathway_Homo sapiens_hsa049150.39884482
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.37621268
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37579301
111Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37459876
112p53 signaling pathway_Homo sapiens_hsa041150.37350597
113Arachidonic acid metabolism_Homo sapiens_hsa005900.36629194
114Hepatitis B_Homo sapiens_hsa051610.35821124
115Salmonella infection_Homo sapiens_hsa051320.35820654
116Acute myeloid leukemia_Homo sapiens_hsa052210.35363711
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35348786
118Other glycan degradation_Homo sapiens_hsa005110.34590958
119Sphingolipid metabolism_Homo sapiens_hsa006000.33998680
120cAMP signaling pathway_Homo sapiens_hsa040240.33435927
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32909290
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32293501
123VEGF signaling pathway_Homo sapiens_hsa043700.32282807
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26183969
125Choline metabolism in cancer_Homo sapiens_hsa052310.25620515

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