ADAMTS6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Expression of this gene may be regulated by the cytokine TNF-alpha. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1definitive hemopoiesis (GO:0060216)8.32755027
2positive regulation of gamma-delta T cell activation (GO:0046645)5.01455941
3megakaryocyte development (GO:0035855)4.91487680
4regulation of interleukin-12 biosynthetic process (GO:0045075)4.53813380
5hemidesmosome assembly (GO:0031581)4.40950284
6lymphangiogenesis (GO:0001946)4.37693494
7negative T cell selection (GO:0043383)4.31887439
8negative thymic T cell selection (GO:0045060)4.23581707
9negative regulation of chondrocyte differentiation (GO:0032331)4.11259364
10insulin-like growth factor receptor signaling pathway (GO:0048009)3.96773878
11positive regulation by host of viral transcription (GO:0043923)3.94417915
12bone trabecula formation (GO:0060346)3.85858619
13negative regulation of phagocytosis (GO:0050765)3.80207555
14kidney mesenchyme development (GO:0072074)3.79775148
15metanephric mesenchyme development (GO:0072075)3.65284402
16negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.64383279
17negative regulation of fatty acid transport (GO:2000192)3.61093568
18retina vasculature morphogenesis in camera-type eye (GO:0061299)3.60747025
19regulation of gamma-delta T cell activation (GO:0046643)3.59848751
20regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.54829420
21nuclear pore organization (GO:0006999)3.54732673
22artery development (GO:0060840)3.54624089
23negative regulation of T-helper cell differentiation (GO:0045623)3.53252772
24negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.53252772
25embryonic process involved in female pregnancy (GO:0060136)3.53094666
26positive thymic T cell selection (GO:0045059)3.51420736
27regulation of isotype switching to IgG isotypes (GO:0048302)3.43660630
28positive T cell selection (GO:0043368)3.39586603
29cell adhesion mediated by integrin (GO:0033627)3.39461017
30mRNA splice site selection (GO:0006376)3.37214921
31sequestering of extracellular ligand from receptor (GO:0035581)3.36332977
32trabecula formation (GO:0060343)3.35628326
33regulation of transforming growth factor beta2 production (GO:0032909)3.34795769
34paraxial mesoderm development (GO:0048339)3.33587231
35pericardium development (GO:0060039)3.33392747
36positive regulation of osteoblast proliferation (GO:0033690)3.33090155
37endodermal cell differentiation (GO:0035987)3.31341378
38regulation of gamma-delta T cell differentiation (GO:0045586)3.30220075
39negative regulation of cartilage development (GO:0061037)3.29622609
40T cell selection (GO:0045058)3.28590300
41positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.27181004
42negative regulation of axon extension involved in axon guidance (GO:0048843)3.26065183
43chondrocyte proliferation (GO:0035988)3.25391913
44thymic T cell selection (GO:0045061)3.22981371
45lung lobe morphogenesis (GO:0060463)3.15072897
46alternative mRNA splicing, via spliceosome (GO:0000380)3.14624060
47embryonic camera-type eye morphogenesis (GO:0048596)3.12271349
48substrate-dependent cell migration (GO:0006929)3.11701669
49regulation of alpha-beta T cell proliferation (GO:0046640)3.11492388
50wound healing, spreading of epidermal cells (GO:0035313)3.10360357
51hippo signaling (GO:0035329)3.08701030
52regulation of regulatory T cell differentiation (GO:0045589)3.08289029
53negative regulation of axon guidance (GO:1902668)3.07425373
54heart trabecula formation (GO:0060347)3.06196856
55skin morphogenesis (GO:0043589)3.03628079
56positive regulation of keratinocyte differentiation (GO:0045618)3.03164858
57antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.02629878
58antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.02629878
59mesodermal cell differentiation (GO:0048333)3.02059735
60regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.01516122
61positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.00133919
62protein heterotrimerization (GO:0070208)3.00001678
63cell migration involved in sprouting angiogenesis (GO:0002042)2.98767472
64regulation of T cell tolerance induction (GO:0002664)2.95838333
65negative regulation of DNA repair (GO:0045738)2.95804813
66dermatan sulfate biosynthetic process (GO:0030208)2.94949673
67positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.93832763
68extracellular fibril organization (GO:0043206)2.93421196
69mitotic sister chromatid cohesion (GO:0007064)2.93247205
70negative chemotaxis (GO:0050919)2.92604108
71regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.89658710
72regulation of integrin-mediated signaling pathway (GO:2001044)2.89238394
73notochord development (GO:0030903)2.88189988
74negative regulation of alpha-beta T cell activation (GO:0046636)2.86229991
75interferon-gamma production (GO:0032609)2.84119756
76regulation of vitamin D biosynthetic process (GO:0060556)2.81648444
77positive regulation of macrophage activation (GO:0043032)2.81123369
78cochlea morphogenesis (GO:0090103)2.80808277
79negative regulation of T cell mediated immunity (GO:0002710)2.80722174
80negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.79024451
81neural crest cell development (GO:0014032)2.78975375
82regulation of osteoblast proliferation (GO:0033688)2.77550518
83pathway-restricted SMAD protein phosphorylation (GO:0060389)2.76228215
84cardiac epithelial to mesenchymal transition (GO:0060317)2.75616295
85substrate adhesion-dependent cell spreading (GO:0034446)2.74912732
86plasma membrane repair (GO:0001778)2.74741358
87regulation of histone deacetylation (GO:0031063)2.74237800
88cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.74222365
89negative regulation of stem cell proliferation (GO:2000647)2.72397573
90mammary gland development (GO:0030879)2.71030379
91regulation of cartilage development (GO:0061035)2.70801289
92dermatan sulfate metabolic process (GO:0030205)2.70666578
93regulation of chondrocyte differentiation (GO:0032330)2.70021944
94positive regulation of blood vessel endothelial cell migration (GO:0043536)2.68702603
95positive regulation of mRNA catabolic process (GO:0061014)2.68299824
96V(D)J recombination (GO:0033151)2.65093108
97regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.65069223
98homeostasis of number of cells within a tissue (GO:0048873)2.65064154
99multicellular organismal movement (GO:0050879)2.64882537
100musculoskeletal movement (GO:0050881)2.64882537
101lymph node development (GO:0048535)2.64830290
102heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.64051410
103T cell receptor signaling pathway (GO:0050852)2.63863923
104positive regulation of cartilage development (GO:0061036)2.63182127
105regulation of interleukin-2 biosynthetic process (GO:0045076)2.62768533
106positive regulation of mesenchymal cell proliferation (GO:0002053)2.62618468
107embryonic cranial skeleton morphogenesis (GO:0048701)2.62499117
108smooth muscle tissue development (GO:0048745)2.62360527
109embryonic hemopoiesis (GO:0035162)2.62225410
110cell migration involved in heart development (GO:0060973)2.60831849
111regulation of extracellular matrix disassembly (GO:0010715)2.60692293
112limb bud formation (GO:0060174)2.60297601
113negative regulation of keratinocyte proliferation (GO:0010839)2.57877793
114glomerular basement membrane development (GO:0032836)2.56318061
115protein polyglutamylation (GO:0018095)2.56083355
116cell-substrate junction assembly (GO:0007044)2.55521994
117regulation of T cell receptor signaling pathway (GO:0050856)2.54573095
118regulation of hippo signaling (GO:0035330)2.54330252
119nephron tubule morphogenesis (GO:0072078)2.52840899
120nephron epithelium morphogenesis (GO:0072088)2.52840899
121heart morphogenesis (GO:0003007)2.52019363
122antigen receptor-mediated signaling pathway (GO:0050851)2.51262183
123T cell homeostasis (GO:0043029)2.50917880
124positive regulation of humoral immune response (GO:0002922)2.50568335
125nuclear pore complex assembly (GO:0051292)2.50124609
126positive regulation of interleukin-2 production (GO:0032743)2.49411779
127regulation of mesenchymal cell proliferation (GO:0010464)2.49355217
128DNA topological change (GO:0006265)2.48549421
129antigen processing and presentation of endogenous antigen (GO:0019883)2.48500348
130cytoplasmic mRNA processing body assembly (GO:0033962)2.47962958
131regulation of plasminogen activation (GO:0010755)2.47204556
132outflow tract septum morphogenesis (GO:0003148)2.46989441
133protein K11-linked deubiquitination (GO:0035871)2.46832308
134tyrosine phosphorylation of STAT protein (GO:0007260)2.46735930
135lateral sprouting from an epithelium (GO:0060601)2.46386278
136regulation of gonadotropin secretion (GO:0032276)2.46241268
137peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.46209680
138positive regulation of histone deacetylation (GO:0031065)2.46208659
139positive regulation of alpha-beta T cell proliferation (GO:0046641)2.45927596
140anterior/posterior axis specification, embryo (GO:0008595)2.45191053
141embryonic placenta development (GO:0001892)2.45171544
142negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.45115328
143positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)2.44999453
144wound healing, spreading of cells (GO:0044319)2.44468777
145heparin metabolic process (GO:0030202)2.44386107
146heparin biosynthetic process (GO:0030210)2.44386107
147positive regulation of tolerance induction (GO:0002645)2.44385041
148positive regulation of mRNA metabolic process (GO:1903313)2.44117188
149negative regulation of osteoblast proliferation (GO:0033689)2.41953109
150extracellular regulation of signal transduction (GO:1900115)2.41416179
151extracellular negative regulation of signal transduction (GO:1900116)2.41416179
152regulation of axon extension involved in axon guidance (GO:0048841)2.41302760
153negative regulation of BMP signaling pathway (GO:0030514)2.41073858
154renal tubule morphogenesis (GO:0061333)2.40421293
155histone H3-K36 demethylation (GO:0070544)2.40128961
156T cell costimulation (GO:0031295)2.39981650
157regulation of axon guidance (GO:1902667)2.39213756
158negative regulation of alpha-beta T cell differentiation (GO:0046639)2.39203819
159blood vessel maturation (GO:0001955)2.39086856
160positive regulation of RNA splicing (GO:0033120)2.38662838
161valine metabolic process (GO:0006573)2.38600045
162positive regulation of T cell chemotaxis (GO:0010820)2.38318159
163regulation of T cell chemotaxis (GO:0010819)2.38318159
164extracellular matrix organization (GO:0030198)2.37414275
165axon extension involved in axon guidance (GO:0048846)2.37079772
166neuron projection extension involved in neuron projection guidance (GO:1902284)2.37079772
167extracellular structure organization (GO:0043062)2.36883687
168regulation of fibroblast migration (GO:0010762)2.36401729
169sprouting angiogenesis (GO:0002040)2.36333965
170positive regulation of lipid kinase activity (GO:0090218)2.36292951
171collagen metabolic process (GO:0032963)2.36263897
172tongue development (GO:0043586)2.35015157
173negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.34936325
174mesenchymal cell development (GO:0014031)2.34546113
175negative regulation of adaptive immune response (GO:0002820)2.34206679
176growth hormone receptor signaling pathway (GO:0060396)2.34091741
177acrosome reaction (GO:0007340)2.34078991
178collagen fibril organization (GO:0030199)2.34070225
179positive regulation of muscle hypertrophy (GO:0014742)2.33582199
180positive regulation of cardiac muscle hypertrophy (GO:0010613)2.33582199
181lymphocyte costimulation (GO:0031294)2.33402650
182regulation of vitamin metabolic process (GO:0030656)2.33043257
183face development (GO:0060324)2.32960772
184regulation of non-canonical Wnt signaling pathway (GO:2000050)2.32579285
185lung vasculature development (GO:0060426)2.32204132
186mesenchyme morphogenesis (GO:0072132)2.32191004
187cellular response to nicotine (GO:0071316)2.32132848
188mesenchymal-epithelial cell signaling (GO:0060638)2.32082856
189cell proliferation involved in metanephros development (GO:0072203)2.31876302
190regulation of mRNA catabolic process (GO:0061013)2.31027080
191establishment of planar polarity (GO:0001736)2.30643609

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.59935715
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.02536199
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.41684385
4SALL1_21062744_ChIP-ChIP_HESCs_Human4.14867707
5GATA1_22025678_ChIP-Seq_K562_Human4.02875738
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.77849772
7TP63_19390658_ChIP-ChIP_HaCaT_Human3.59609239
8GBX2_23144817_ChIP-Seq_PC3_Human2.92060054
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.80412867
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.76737279
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.74285067
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.62146693
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.60020470
14* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.52589200
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.46866691
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.44796441
17WT1_19549856_ChIP-ChIP_CCG9911_Human2.44236826
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37589745
19RUNX_20019798_ChIP-Seq_JUKART_Human2.33438920
20TP53_18474530_ChIP-ChIP_U2OS_Human2.31132420
21* GATA2_21666600_ChIP-Seq_HMVEC_Human2.24403439
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.23198254
23TP53_16413492_ChIP-PET_HCT116_Human2.19857621
24TRIM28_21343339_ChIP-Seq_HEK293_Human2.14839179
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.08129915
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.97307746
27CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.94155130
28* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.90119495
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.89977457
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.89158613
31E2F7_22180533_ChIP-Seq_HELA_Human1.82455170
32* P300_19829295_ChIP-Seq_ESCs_Human1.82344142
33CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.81459125
34* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.79589947
35MYC_22102868_ChIP-Seq_BL_Human1.76677627
36ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.76272938
37* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.76244342
38NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.75791235
39NRF2_20460467_ChIP-Seq_MEFs_Mouse1.75791235
40MYB_26560356_Chip-Seq_TH1_Human1.67032215
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61603992
42* TAF15_26573619_Chip-Seq_HEK293_Human1.60500086
43MYB_26560356_Chip-Seq_TH2_Human1.57243735
44* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55268453
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52472843
46SCL_19346495_ChIP-Seq_HPC-7_Human1.47333283
47AR_21572438_ChIP-Seq_LNCaP_Human1.47258396
48* BRD4_25478319_ChIP-Seq_HGPS_Human1.46097928
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45801604
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45354672
51* STAT3_23295773_ChIP-Seq_U87_Human1.45301160
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44746513
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44173889
54TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.42716820
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.42189184
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41743945
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.41565652
58CJUN_26792858_Chip-Seq_BT549_Human1.40964405
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39723197
60* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.38971352
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37496221
62DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.37341559
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.36704638
64AHR_22903824_ChIP-Seq_MCF-7_Human1.35734283
65AR_25329375_ChIP-Seq_VCAP_Human1.35169885
66EP300_21415370_ChIP-Seq_HL-1_Mouse1.32009432
67* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31771122
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31450022
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30310384
70EED_16625203_ChIP-ChIP_MESCs_Mouse1.30049639
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29677104
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28378655
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.27898522
74BCAT_22108803_ChIP-Seq_LS180_Human1.27649284
75ER_23166858_ChIP-Seq_MCF-7_Human1.26847009
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26780884
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.26607984
78HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26512102
79MAF_26560356_Chip-Seq_TH1_Human1.24854965
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23150183
81FUS_26573619_Chip-Seq_HEK293_Human1.22241674
82* SOX9_26525672_Chip-Seq_HEART_Mouse1.21646333
83SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21627257
84* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20216667
85KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19721607
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19519896
87DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19355647
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.16861465
89TP63_23658742_ChIP-Seq_EP156T_Human1.16738804
90KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14956416
91* CBP_20019798_ChIP-Seq_JUKART_Human1.14319213
92* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14319213
93RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13613499
94RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12683162
95UTX_26944678_Chip-Seq_JUKART_Human1.12323517
96GATA3_27048872_Chip-Seq_THYMUS_Human1.12177826
97CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11613926
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09077024
99TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07304723
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06948649
101* TCF4_23295773_ChIP-Seq_U87_Human1.06616032
102PU_27001747_Chip-Seq_BMDM_Mouse1.05908831
103ESR1_20079471_ChIP-ChIP_T-47D_Human1.05731929
104POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05448803
105KDM2B_26808549_Chip-Seq_REH_Human1.05280625
106CBX2_27304074_Chip-Seq_ESCs_Mouse1.05232303
107P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05128446
108CIITA_25753668_ChIP-Seq_RAJI_Human1.04995587
109EWS_26573619_Chip-Seq_HEK293_Human1.04919964
110* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04590194
111* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04590194
112CDX2_22108803_ChIP-Seq_LS180_Human1.04519704
113* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.04206669
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03765829
115TBL1_22424771_ChIP-Seq_293T_Human1.03076500
116* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02881080
117TCF7_22412390_ChIP-Seq_EML_Mouse1.02864677
118* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02520509
119* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02502029
120PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02497582
121* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.01919283
122E2F1_18555785_Chip-Seq_ESCs_Mouse1.01836794
123SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01536247
124* RUNX2_22187159_ChIP-Seq_PCA_Human1.00724759
125PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99498396
126SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.99198409
127CLOCK_20551151_ChIP-Seq_293T_Human0.97470889
128* ELK1_19687146_ChIP-ChIP_HELA_Human0.97441921
129* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96523350
130E2F4_17652178_ChIP-ChIP_JURKAT_Human0.95204619
131KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94828973
132NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93542374
133TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89826982
134* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88949134
135FLI1_27457419_Chip-Seq_LIVER_Mouse0.87785325
136FOXO3_23340844_ChIP-Seq_DLD1_Human0.87660945
137ISL1_27105846_Chip-Seq_CPCs_Mouse0.87652520
138TP63_17297297_ChIP-ChIP_HaCaT_Human0.87264707
139SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86298561
140SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85921098
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85737956
142MYB_21317192_ChIP-Seq_ERMYB_Mouse0.83613601
143EZH2_27294783_Chip-Seq_NPCs_Mouse0.82244274
144KDM2B_26808549_Chip-Seq_DND41_Human0.81219978
145* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.81043264
146PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80916081
147E2F1_21310950_ChIP-Seq_MCF-7_Human0.80566005
148TCF4_18268006_ChIP-ChIP_LS174T_Human0.79972283
149NFE2_27457419_Chip-Seq_LIVER_Mouse0.79770370
150FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.79501652
151VDR_24787735_ChIP-Seq_THP-1_Human0.79174862
152JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79041391
153FOXM1_26456572_ChIP-Seq_MCF-7_Human0.78222579
154JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77813994
155KDM2B_26808549_Chip-Seq_JURKAT_Human0.77058334
156RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.76022021
157HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.74855956
158SMAD4_21799915_ChIP-Seq_A2780_Human0.74344684
159NFIB_24661679_ChIP-Seq_LUNG_Mouse0.73996800
160SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.73080075

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.96943075
2MP0005503_abnormal_tendon_morphology3.95673324
3MP0003279_aneurysm3.59382467
4MP0003950_abnormal_plasma_membrane3.47104788
5MP0003787_abnormal_imprinting3.28358361
6MP0010030_abnormal_orbit_morphology2.94642712
7MP0003763_abnormal_thymus_physiology2.83636745
8MP0002396_abnormal_hematopoietic_system2.60832586
9MP0003121_genomic_imprinting2.47470849
10MP0003941_abnormal_skin_development2.29008821
11MP0006054_spinal_hemorrhage2.23992707
12MP0004808_abnormal_hematopoietic_stem2.16086904
13MP0005275_abnormal_skin_tensile2.11939906
14MP0000569_abnormal_digit_pigmentation2.11516709
15MP0004510_myositis2.07706619
16MP0001958_emphysema1.99123857
17MP0009053_abnormal_anal_canal1.98324256
18MP0005257_abnormal_intraocular_pressure1.94549212
19MP0002938_white_spotting1.88480832
20MP0008007_abnormal_cellular_replicative1.83095650
21MP0005623_abnormal_meninges_morphology1.80051681
22MP0003943_abnormal_hepatobiliary_system1.74606841
23MP0000767_abnormal_smooth_muscle1.72619669
24MP0003300_gastrointestinal_ulcer1.69408982
25MP0000762_abnormal_tongue_morphology1.66242558
26MP0000465_gastrointestinal_hemorrhage1.66211852
27MP0005409_darkened_coat_color1.65290351
28MP0002234_abnormal_pharynx_morphology1.64943838
29MP0003942_abnormal_urinary_system1.63731973
30MP0002166_altered_tumor_susceptibility1.63635227
31MP0010352_gastrointestinal_tract_polyps1.61516964
32MP0000534_abnormal_ureter_morphology1.61277303
33MP0009697_abnormal_copulation1.61193566
34MP0005671_abnormal_response_to1.58618868
35MP0009384_cardiac_valve_regurgitation1.57707388
36MP0000685_abnormal_immune_system1.55425711
37MP0010368_abnormal_lymphatic_system1.52939015
38MP0010630_abnormal_cardiac_muscle1.51858151
39MP0001177_atelectasis1.51777137
40MP0003122_maternal_imprinting1.51464310
41MP0005508_abnormal_skeleton_morphology1.50712699
42MP0003183_abnormal_peptide_metabolism1.47930871
43MP0002295_abnormal_pulmonary_circulatio1.47902976
44MP0003385_abnormal_body_wall1.46450134
45MP0009780_abnormal_chondrocyte_physiolo1.43221213
46MP0003755_abnormal_palate_morphology1.41210580
47MP0000428_abnormal_craniofacial_morphol1.40826600
48MP0003937_abnormal_limbs/digits/tail_de1.39994047
49MP0003123_paternal_imprinting1.39442400
50MP0000733_abnormal_muscle_development1.31880253
51MP0003091_abnormal_cell_migration1.28982042
52MP0002933_joint_inflammation1.28580434
53MP0002128_abnormal_blood_circulation1.27781298
54MP0002006_tumorigenesis1.27053918
55MP0000703_abnormal_thymus_morphology1.26474990
56MP0003935_abnormal_craniofacial_develop1.25710280
57MP0004272_abnormal_basement_membrane1.22173897
58MP0001879_abnormal_lymphatic_vessel1.21466379
59MP0009250_abnormal_appendicular_skeleto1.20790172
60MP0001348_abnormal_lacrimal_gland1.20294673
61MP0003566_abnormal_cell_adhesion1.17316638
62MP0000678_abnormal_parathyroid_gland1.16923295
63MP0002398_abnormal_bone_marrow1.16624846
64MP0001800_abnormal_humoral_immune1.16385719
65MP0001790_abnormal_immune_system1.14874577
66MP0005387_immune_system_phenotype1.14874577
67MP0001293_anophthalmia1.13944150
68MP0001915_intracranial_hemorrhage1.12953991
69MP0003806_abnormal_nucleotide_metabolis1.11869334
70MP0002060_abnormal_skin_morphology1.11613482
71MP0000566_synostosis1.11146228
72MP0005595_abnormal_vascular_smooth1.10658597
73MP0002089_abnormal_postnatal_growth/wei1.10439533
74MP0000432_abnormal_head_morphology1.10408913
75MP0002249_abnormal_larynx_morphology1.10040649
76MP0002896_abnormal_bone_mineralization1.09102956
77MP0002282_abnormal_trachea_morphology1.08979737
78MP0002233_abnormal_nose_morphology1.08230592
79MP0002127_abnormal_cardiovascular_syste1.07857208
80MP0001542_abnormal_bone_strength1.07701049
81MP0001299_abnormal_eye_distance/1.03948738
82MP0001243_abnormal_dermal_layer1.03003938
83MP0004084_abnormal_cardiac_muscle1.02157046
84MP0002405_respiratory_system_inflammati1.01692734
85MP0002168_other_aberrant_phenotype1.01684432
86MP0001346_abnormal_lacrimal_gland0.99945444
87MP0002115_abnormal_skeleton_extremities0.99644608
88MP0002009_preneoplasia0.99526689
89MP0002925_abnormal_cardiovascular_devel0.99447878
90MP0003567_abnormal_fetal_cardiomyocyte0.99137391
91MP0000013_abnormal_adipose_tissue0.97652598
92MP0006138_congestive_heart_failure0.95958414
93MP0003303_peritoneal_inflammation0.95419609
94MP0002697_abnormal_eye_size0.95188266
95MP0005197_abnormal_uvea_morphology0.94831692
96MP0009333_abnormal_splenocyte_physiolog0.94741308
97MP0000049_abnormal_middle_ear0.94671386
98MP0001286_abnormal_eye_development0.94637566
99MP0000537_abnormal_urethra_morphology0.93314148
100MP0003705_abnormal_hypodermis_morpholog0.93286314
101MP0005171_absent_coat_pigmentation0.93283758
102MP0003115_abnormal_respiratory_system0.92126665
103MP0000749_muscle_degeneration0.91865305
104MP0002113_abnormal_skeleton_development0.91575210
105MP0002108_abnormal_muscle_morphology0.91242569
106MP0005410_abnormal_fertilization0.91204196
107MP0001175_abnormal_lung_morphology0.90890320
108MP0000579_abnormal_nail_morphology0.89897753
109MP0005023_abnormal_wound_healing0.89339085
110MP0005000_abnormal_immune_tolerance0.88930916
111MP0002109_abnormal_limb_morphology0.88687430
112MP0008961_abnormal_basal_metabolism0.88469535
113MP0002116_abnormal_craniofacial_bone0.88424457
114MP0002932_abnormal_joint_morphology0.88019305
115MP0000613_abnormal_salivary_gland0.87564377
116MP0000689_abnormal_spleen_morphology0.87519197
117MP0000490_abnormal_crypts_of0.86680518
118MP0000266_abnormal_heart_morphology0.86538287
119MP0004134_abnormal_chest_morphology0.84367586
120MP0010386_abnormal_urinary_bladder0.84172933
121MP0004087_abnormal_muscle_fiber0.84087386
122MP0005390_skeleton_phenotype0.84070920
123MP0000163_abnormal_cartilage_morphology0.83453728
124MP0002102_abnormal_ear_morphology0.83449319
125MP0001614_abnormal_blood_vessel0.83364601
126MP0002998_abnormal_bone_remodeling0.82823635
127MP0001853_heart_inflammation0.82414531
128MP0000003_abnormal_adipose_tissue0.82074545
129MP0000383_abnormal_hair_follicle0.81464098
130MP0002722_abnormal_immune_system0.80697984
131MP0001544_abnormal_cardiovascular_syste0.80017464
132MP0005385_cardiovascular_system_phenoty0.80017464
133MP0002420_abnormal_adaptive_immunity0.79191423
134MP0002452_abnormal_antigen_presenting0.78701691
135MP0004197_abnormal_fetal_growth/weight/0.78584005
136MP0000716_abnormal_immune_system0.77926180
137MP0005369_muscle_phenotype0.76529117
138MP0002114_abnormal_axial_skeleton0.71346146
139MP0002092_abnormal_eye_morphology0.70222778
140MP0005084_abnormal_gallbladder_morpholo0.68947521
141MP0002160_abnormal_reproductive_system0.67225504
142MP0005187_abnormal_penis_morphology0.67126775
143MP0000467_abnormal_esophagus_morphology0.66161559
144MP0002928_abnormal_bile_duct0.65705409
145MP0002084_abnormal_developmental_patter0.63246327
146MP0003283_abnormal_digestive_organ0.62493395
147MP0005395_other_phenotype0.62449358
148MP0000647_abnormal_sebaceous_gland0.62319369
149MP0002085_abnormal_embryonic_tissue0.62207729
150MP0000538_abnormal_urinary_bladder0.60500521
151MP0005391_vision/eye_phenotype0.57722887
152MP0002177_abnormal_outer_ear0.57542210
153MP0003936_abnormal_reproductive_system0.57246367
154MP0008775_abnormal_heart_ventricle0.57195837
155MP0002163_abnormal_gland_morphology0.56414553
156MP0002133_abnormal_respiratory_system0.55701460

Predicted human phenotypes

RankGene SetZ-score
1Arterial tortuosity (HP:0005116)4.08231730
2Absent frontal sinuses (HP:0002688)3.93230595
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.87784897
4Short 4th metacarpal (HP:0010044)3.87784897
5Neonatal short-limb short stature (HP:0008921)3.73454804
6Mesomelia (HP:0003027)3.69573920
7Abnormality of T cell number (HP:0011839)3.48251882
8T lymphocytopenia (HP:0005403)3.38584338
9Abnormal hair whorl (HP:0010721)3.33420323
10Protrusio acetabuli (HP:0003179)3.31883164
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.19542600
12Aortic aneurysm (HP:0004942)3.12947111
13Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.08890824
14Aortic dissection (HP:0002647)3.02858840
15Abnormality of the fingertips (HP:0001211)2.96826082
16Overgrowth (HP:0001548)2.93982002
17Broad metatarsal (HP:0001783)2.88849358
18Fragile skin (HP:0001030)2.86756127
19Dilatation of the ascending aorta (HP:0005111)2.81818822
20Volvulus (HP:0002580)2.81407894
21Premature rupture of membranes (HP:0001788)2.69718483
22Long eyelashes (HP:0000527)2.69485300
23Hypoplasia of the iris (HP:0007676)2.69021586
24Abnormality of the ischium (HP:0003174)2.68051245
25Abnormality of the parietal bone (HP:0002696)2.67132033
26Hypoplastic ischia (HP:0003175)2.59977253
27Abnormality of the 4th metacarpal (HP:0010012)2.53939994
28Mitral valve prolapse (HP:0001634)2.53681658
29Wrist flexion contracture (HP:0001239)2.50976424
30Hypochromic microcytic anemia (HP:0004840)2.50624395
31Spinal cord lesions (HP:0100561)2.46895269
32Syringomyelia (HP:0003396)2.46895269
33Subacute progressive viral hepatitis (HP:0006572)2.46399005
34Wide anterior fontanel (HP:0000260)2.46289384
35Bowel diverticulosis (HP:0005222)2.44991141
36Increased density of long bones (HP:0006392)2.43806061
37Coronal craniosynostosis (HP:0004440)2.42167531
38Broad face (HP:0000283)2.41231058
39Thin bony cortex (HP:0002753)2.38324849
40Hypoplastic labia majora (HP:0000059)2.36863388
41Shallow orbits (HP:0000586)2.35424080
42Bell-shaped thorax (HP:0001591)2.35257972
43Hepatoblastoma (HP:0002884)2.34232050
44Osteolytic defects of the hand bones (HP:0009699)2.31606448
45Osteolytic defects of the phalanges of the hand (HP:0009771)2.31606448
46Increased corneal curvature (HP:0100692)2.31515509
47Keratoconus (HP:0000563)2.31515509
48Abnormal platelet volume (HP:0011876)2.30846979
49Limited hip movement (HP:0008800)2.29960246
50Hypochromic anemia (HP:0001931)2.27185354
51Infantile muscular hypotonia (HP:0008947)2.27074207
52Protruding tongue (HP:0010808)2.24917129
53Abnormality of the labia majora (HP:0012881)2.24470855
54Follicular hyperkeratosis (HP:0007502)2.23322982
55Mitral regurgitation (HP:0001653)2.21631015
56Aortic regurgitation (HP:0001659)2.21240176
57Atrophic scars (HP:0001075)2.19685411
58Abnormality of the acetabulum (HP:0003170)2.19476388
59Genu recurvatum (HP:0002816)2.18870584
60Abnormality of the frontal sinuses (HP:0002687)2.18860242
61Centrally nucleated skeletal muscle fibers (HP:0003687)2.17133235
62Striae distensae (HP:0001065)2.16858233
63Wormian bones (HP:0002645)2.15428496
64Spondylolisthesis (HP:0003302)2.14030420
65Increased mean platelet volume (HP:0011877)2.13428344
66Narrow palate (HP:0000189)2.12162088
67Acute myeloid leukemia (HP:0004808)2.12034398
68Ankle contracture (HP:0006466)2.09948308
69Abnormality of T cells (HP:0002843)2.09189267
70Limb hypertonia (HP:0002509)2.08239037
71Cerebral aneurysm (HP:0004944)2.06772645
72Hyperextensible skin (HP:0000974)2.04234526
73Anteriorly placed anus (HP:0001545)2.03711592
74Dislocated radial head (HP:0003083)2.02281075
75Abnormality of the distal phalanx of the thumb (HP:0009617)2.00968274
76Aplasia cutis congenita (HP:0001057)2.00539778
77Abnormality of the nasal septum (HP:0000419)1.99243131
78Knee flexion contracture (HP:0006380)1.99121193
79Natal tooth (HP:0000695)1.98700873
80Cardiovascular calcification (HP:0011915)1.98576900
81Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.96032582
82Biconcave vertebral bodies (HP:0004586)1.95233607
83Increased number of teeth (HP:0011069)1.95179235
84Vascular tortuosity (HP:0004948)1.93203487
85Mitral stenosis (HP:0001718)1.92420309
86Chronic mucocutaneous candidiasis (HP:0002728)1.91735273
87Recurrent cutaneous fungal infections (HP:0011370)1.91735273
88Chronic hepatic failure (HP:0100626)1.90304456
89Abnormality of T cell physiology (HP:0011840)1.88992291
90Soft skin (HP:0000977)1.88932717
91Abnormality of the radial head (HP:0003995)1.88566698
92Septate vagina (HP:0001153)1.87440479
93Bladder diverticulum (HP:0000015)1.86196873
94Broad toe (HP:0001837)1.86179210
95Cervical subluxation (HP:0003308)1.85036677
96Prolonged bleeding time (HP:0003010)1.84464012
97Abnormality of the proximal phalanges of the hand (HP:0009834)1.84267638
98Mild short stature (HP:0003502)1.82947236
99Pterygium (HP:0001059)1.82928691
100Slender build (HP:0001533)1.82598609
101Milia (HP:0001056)1.82503049
102Agammaglobulinemia (HP:0004432)1.80003408
103Broad long bones (HP:0005622)1.77858310
104Broad ribs (HP:0000885)1.77339280
105Chronic otitis media (HP:0000389)1.77320741
106Hypoplastic pelvis (HP:0008839)1.76865273
107Oligodontia (HP:0000677)1.75719351
108Entropion (HP:0000621)1.75554469
109Ectopia lentis (HP:0001083)1.75542294
110Abnormality of the nasolacrimal system (HP:0000614)1.75364900
111Spinal rigidity (HP:0003306)1.75056381
112Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.75026574
113Broad palm (HP:0001169)1.74279420
114Type 1 muscle fiber predominance (HP:0003803)1.74221069
115Short nail (HP:0001799)1.73519687
116Aortic valve stenosis (HP:0001650)1.73373798
117Thrombocytosis (HP:0001894)1.73121352
118Nemaline bodies (HP:0003798)1.73042394
119Recurrent viral infections (HP:0004429)1.72912767
120Long clavicles (HP:0000890)1.71371298
121Broad phalanx (HP:0006009)1.71195273
122Blue sclerae (HP:0000592)1.70302170
123Decreased lacrimation (HP:0000633)1.69798433
124Hip contracture (HP:0003273)1.69526885
125Tibial bowing (HP:0002982)1.68874224
126Peritonitis (HP:0002586)1.68868154
127Joint laxity (HP:0001388)1.68729017
128Osteoarthritis (HP:0002758)1.68197535
129Chronic diarrhea (HP:0002028)1.68152448
130Distal lower limb amyotrophy (HP:0008944)1.67552284
131Renal duplication (HP:0000075)1.67308710
132Synostosis of carpal bones (HP:0005048)1.67261427
133IgG deficiency (HP:0004315)1.66979053
134Abnormal delivery (HP:0001787)1.66974234
135Abnormality of dentin (HP:0010299)1.66930500
136Broad finger (HP:0001500)1.66731195
137Lower limb amyotrophy (HP:0007210)1.66073431
138Long palpebral fissure (HP:0000637)1.66020068
139Camptodactyly of toe (HP:0001836)1.65895403
140Aplasia/Hypoplasia of the tongue (HP:0010295)1.65875123
141Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.65811513
142Poikiloderma (HP:0001029)1.64928210
143Lumbar hyperlordosis (HP:0002938)1.64735000
144Broad phalanges of the hand (HP:0009768)1.64188340
145Round ear (HP:0100830)1.62171102
146Elbow flexion contracture (HP:0002987)1.61225549
147Hypoplastic ilia (HP:0000946)1.60502809
148Tubulointerstitial nephritis (HP:0001970)1.59466520
149Bifid tongue (HP:0010297)1.58336243
150Abnormality of the epiphyses of the hand (HP:0005924)1.57646199
151Abnormal ossification of hand bones (HP:0005921)1.56548167
152True hermaphroditism (HP:0010459)1.56419211
153Chorioretinal atrophy (HP:0000533)1.55491261
154Rhizomelia (HP:0008905)1.54419610
155Pancreatic fibrosis (HP:0100732)1.53914529
156Abnormality of the anterior chamber (HP:0000593)1.52682322

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B6.80664420
2STK244.78683428
3PNCK4.08550326
4TXK3.42118076
5STK38L3.31064956
6EPHB23.20283831
7TIE13.19421797
8AKT32.73498381
9NEK92.70997332
10PLK42.43377194
11MET2.36110803
12MAP3K142.20424715
13MAP4K12.19777917
14BRSK22.12385042
15MKNK12.07212974
16TEC1.96216495
17FLT31.91801423
18PTK21.91672442
19PIK3CA1.90633600
20STK31.89541290
21PBK1.85789960
22CHUK1.70565666
23ITK1.67871568
24STK381.65520436
25RPS6KA41.60850693
26TTN1.54930201
27ERBB31.54690024
28PLK21.53590711
29MUSK1.51376877
30WNK11.50375046
31FRK1.50001253
32MKNK21.49641351
33TGFBR11.48181365
34TRPM71.45633193
35PRKCH1.44338770
36JAK31.37554336
37MAP3K121.35675291
38WEE11.32856986
39BMPR1B1.31800476
40MST1R1.28033894
41DMPK1.21808058
42PDGFRB1.19862090
43CDC42BPA1.17894310
44PRKD31.16881027
45FGFR31.12649075
46LATS21.11975114
47PRKD21.09867834
48SIK31.09388065
49CDK81.07919226
50TAOK21.06974954
51NTRK11.06191124
52PKN21.06115890
53KIT1.05636650
54WNK31.05103812
55EIF2AK31.03963741
56SGK31.03173489
57IKBKB1.02699252
58ZAP701.02359375
59PASK0.97630416
60PIK3CG0.97330573
61CAMK1G0.96060956
62STK390.93847816
63DDR20.93572426
64ERBB40.93199429
65IKBKE0.92903097
66HCK0.92543773
67SIK10.91851919
68INSRR0.91035393
69WNK40.91028438
70TRIB30.90606126
71STK160.89253077
72LCK0.87260062
73FGFR20.86275282
74CASK0.83004197
75STK100.82116000
76MAPK150.81764196
77PDGFRA0.79422075
78MELK0.76860472
79BTK0.76426306
80BRD40.75035662
81MAPKAPK50.74917243
82EIF2AK10.73266064
83RPS6KA50.73137387
84CLK10.72972713
85SGK20.72226092
86PAK20.72007427
87CDK120.71270182
88PIM10.70967541
89OBSCN0.69857467
90NEK20.69751598
91PRKCE0.66947406
92MAP3K100.66595055
93PRKCQ0.65581951
94ZAK0.65073485
95MOS0.65017600
96TAF10.64132914
97PLK30.62647782
98EEF2K0.62375665
99IGF1R0.62042733
100LRRK20.61241091
101BRSK10.60078785
102TGFBR20.59862725
103ROCK10.59060096
104NEK60.58131345
105FER0.57782162
106INSR0.56526927
107RPS6KB10.56110494
108CSK0.55402383
109ADRBK10.52555752
110AURKB0.50302776
111MAP3K70.50130657
112CHEK20.49926463
113NLK0.49231192
114BCR0.48774873
115LATS10.48537870
116YES10.48534828
117JAK10.48230312
118LYN0.47682257
119RPS6KA60.47451133
120FGFR40.46862754
121MTOR0.46766722
122NEK10.45888193
123FGFR10.45692035
124LIMK10.45127604
125GSK3A0.45069537
126CCNB10.44803038
127ATR0.44638084
128BMPR20.44476373
129MAPK80.44459148
130EPHA20.44377174
131ALK0.44370549
132ILK0.43629426
133PTK60.43615595
134MAPKAPK30.43504873
135PTK2B0.43463925
136CSNK1A1L0.42771388
137MYLK0.42471725
138PAK40.41260193
139PKN10.40919205
140NUAK10.40260544
141VRK10.40176264
142MAPK70.39875750
143TBK10.39098703
144EPHA40.38317945
145PLK10.37935649
146CSNK1D0.37762930
147ATM0.35956286
148FES0.35913311
149CDK60.35493348
150MAPK30.34684999
151PRKG10.34389430
152SRC0.34111749
153PRKD10.33566790
154MAP2K10.33166602
155PRKG20.33085334
156ROCK20.31897293
157PAK30.31320512
158ABL20.30895810
159CHEK10.29817674
160PAK60.26265842
161DAPK30.26003388

Predicted pathways (KEGG)

RankGene SetZ-score
1Hedgehog signaling pathway_Homo sapiens_hsa043403.02154510
2Primary immunodeficiency_Homo sapiens_hsa053402.70366669
3Hippo signaling pathway_Homo sapiens_hsa043902.46732224
4Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.44514460
5T cell receptor signaling pathway_Homo sapiens_hsa046602.44400861
6Measles_Homo sapiens_hsa051622.25278385
7Allograft rejection_Homo sapiens_hsa053302.14509422
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.00551723
9B cell receptor signaling pathway_Homo sapiens_hsa046621.97410092
10Chronic myeloid leukemia_Homo sapiens_hsa052201.80292804
11ECM-receptor interaction_Homo sapiens_hsa045121.79095370
12Graft-versus-host disease_Homo sapiens_hsa053321.78793216
13Viral myocarditis_Homo sapiens_hsa054161.77174733
14Focal adhesion_Homo sapiens_hsa045101.71346078
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.70099766
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.63953319
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.61241532
18Non-homologous end-joining_Homo sapiens_hsa034501.60537453
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.58979341
20Melanoma_Homo sapiens_hsa052181.55493225
21Transcriptional misregulation in cancer_Homo sapiens_hsa052021.55400735
22Dilated cardiomyopathy_Homo sapiens_hsa054141.55278252
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.52024053
24Nucleotide excision repair_Homo sapiens_hsa034201.49296065
25Small cell lung cancer_Homo sapiens_hsa052221.48017375
26Autoimmune thyroid disease_Homo sapiens_hsa053201.43908488
27MicroRNAs in cancer_Homo sapiens_hsa052061.41468960
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.40518565
29Type I diabetes mellitus_Homo sapiens_hsa049401.39854581
30Platelet activation_Homo sapiens_hsa046111.36921681
31Hematopoietic cell lineage_Homo sapiens_hsa046401.35827342
32HTLV-I infection_Homo sapiens_hsa051661.35717229
33Herpes simplex infection_Homo sapiens_hsa051681.35513588
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.35269788
35Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.34822521
36Shigellosis_Homo sapiens_hsa051311.32926686
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.32434489
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.30700185
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30016372
40Toxoplasmosis_Homo sapiens_hsa051451.30008994
41Legionellosis_Homo sapiens_hsa051341.29684439
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28499226
43Leishmaniasis_Homo sapiens_hsa051401.27084869
44Malaria_Homo sapiens_hsa051441.27034279
45Fanconi anemia pathway_Homo sapiens_hsa034601.26720033
46Prostate cancer_Homo sapiens_hsa052151.26222170
47Acute myeloid leukemia_Homo sapiens_hsa052211.25965461
48Antigen processing and presentation_Homo sapiens_hsa046121.25043436
49Axon guidance_Homo sapiens_hsa043601.23398902
50Intestinal immune network for IgA production_Homo sapiens_hsa046721.19475588
51Prolactin signaling pathway_Homo sapiens_hsa049171.16833306
52Osteoclast differentiation_Homo sapiens_hsa043801.15539740
53Tight junction_Homo sapiens_hsa045301.13923843
54Pancreatic cancer_Homo sapiens_hsa052121.13730321
55One carbon pool by folate_Homo sapiens_hsa006701.12936269
56TNF signaling pathway_Homo sapiens_hsa046681.12433524
57Proteoglycans in cancer_Homo sapiens_hsa052051.11662814
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.11157275
59N-Glycan biosynthesis_Homo sapiens_hsa005101.10477457
60Influenza A_Homo sapiens_hsa051641.10343563
61Amoebiasis_Homo sapiens_hsa051461.08630090
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.08625157
63PI3K-Akt signaling pathway_Homo sapiens_hsa041511.07419316
64TGF-beta signaling pathway_Homo sapiens_hsa043501.06940534
65Hepatitis B_Homo sapiens_hsa051611.06711620
66Dorso-ventral axis formation_Homo sapiens_hsa043201.05274485
67Adherens junction_Homo sapiens_hsa045201.05217670
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02186621
69Gap junction_Homo sapiens_hsa045401.00644464
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00156695
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98435235
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96075412
73Melanogenesis_Homo sapiens_hsa049160.96041512
74Selenocompound metabolism_Homo sapiens_hsa004500.93274365
75Chemokine signaling pathway_Homo sapiens_hsa040620.87464937
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.86571726
77Basal cell carcinoma_Homo sapiens_hsa052170.86372084
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84363216
79Fatty acid biosynthesis_Homo sapiens_hsa000610.83900846
80Endometrial cancer_Homo sapiens_hsa052130.83571233
81Protein export_Homo sapiens_hsa030600.82469405
82Bladder cancer_Homo sapiens_hsa052190.80842526
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.78962906
84Rap1 signaling pathway_Homo sapiens_hsa040150.78333784
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.78185220
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78146568
87Base excision repair_Homo sapiens_hsa034100.77376731
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75878776
89Viral carcinogenesis_Homo sapiens_hsa052030.75760716
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75388702
91Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72861182
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.72790991
93Renal cell carcinoma_Homo sapiens_hsa052110.72659559
94Pathways in cancer_Homo sapiens_hsa052000.72613233
95Colorectal cancer_Homo sapiens_hsa052100.72152434
96RNA degradation_Homo sapiens_hsa030180.71326037
97MAPK signaling pathway_Homo sapiens_hsa040100.69450859
98HIF-1 signaling pathway_Homo sapiens_hsa040660.67105826
99Epstein-Barr virus infection_Homo sapiens_hsa051690.66379140
100Circadian rhythm_Homo sapiens_hsa047100.66290795
101p53 signaling pathway_Homo sapiens_hsa041150.66189693
102Thyroid cancer_Homo sapiens_hsa052160.65725146
103Wnt signaling pathway_Homo sapiens_hsa043100.65400793
104Non-small cell lung cancer_Homo sapiens_hsa052230.62748664
105RNA transport_Homo sapiens_hsa030130.61371671
106Insulin resistance_Homo sapiens_hsa049310.60288433
107FoxO signaling pathway_Homo sapiens_hsa040680.59987101
108Lysine degradation_Homo sapiens_hsa003100.59400258
109Homologous recombination_Homo sapiens_hsa034400.58899089
110Complement and coagulation cascades_Homo sapiens_hsa046100.58856639
111Ras signaling pathway_Homo sapiens_hsa040140.58502877
112Hepatitis C_Homo sapiens_hsa051600.58450438
113ErbB signaling pathway_Homo sapiens_hsa040120.58146181
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57734666
115Cell cycle_Homo sapiens_hsa041100.57637530
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57570004
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57563595
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57223672
119Apoptosis_Homo sapiens_hsa042100.56494410
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56445550
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54249558
122Glycerolipid metabolism_Homo sapiens_hsa005610.53727598
123Basal transcription factors_Homo sapiens_hsa030220.53647049
124mRNA surveillance pathway_Homo sapiens_hsa030150.53535961
125Choline metabolism in cancer_Homo sapiens_hsa052310.53321525
126Protein digestion and absorption_Homo sapiens_hsa049740.52525186
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52476945
128Glioma_Homo sapiens_hsa052140.51758176
129Alcoholism_Homo sapiens_hsa050340.51239614
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50626406
131Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50534612
132Ovarian steroidogenesis_Homo sapiens_hsa049130.48821179
133cAMP signaling pathway_Homo sapiens_hsa040240.48763010
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.47534144
135Propanoate metabolism_Homo sapiens_hsa006400.47134627
136Mismatch repair_Homo sapiens_hsa034300.45644467
137Calcium signaling pathway_Homo sapiens_hsa040200.44515938
138Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44477635
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41978900
140Thyroid hormone synthesis_Homo sapiens_hsa049180.40767564
141Steroid hormone biosynthesis_Homo sapiens_hsa001400.40053635
142Primary bile acid biosynthesis_Homo sapiens_hsa001200.39988598
143Olfactory transduction_Homo sapiens_hsa047400.38290778
144Serotonergic synapse_Homo sapiens_hsa047260.37114787
145Salivary secretion_Homo sapiens_hsa049700.32384246
146Endocytosis_Homo sapiens_hsa041440.31641627
147Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28826962
148Taste transduction_Homo sapiens_hsa047420.28611512
149Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28155475
150Long-term depression_Homo sapiens_hsa047300.25048340
151ABC transporters_Homo sapiens_hsa020100.23858191
152Steroid biosynthesis_Homo sapiens_hsa001000.23067002
153Purine metabolism_Homo sapiens_hsa002300.22897653

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