ADAMTS7P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)6.95993727
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.95993727
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.51610143
4positive regulation of gamma-delta T cell activation (GO:0046645)5.87112014
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.31980164
6tolerance induction (GO:0002507)5.21416826
7regulation of gamma-delta T cell differentiation (GO:0045586)5.00311700
8antigen processing and presentation of endogenous antigen (GO:0019883)4.94298081
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.85181268
10regulation of gamma-delta T cell activation (GO:0046643)4.82399096
11response to interleukin-15 (GO:0070672)4.80749259
12negative T cell selection (GO:0043383)4.80665468
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.75930776
14negative thymic T cell selection (GO:0045060)4.74924945
15leukocyte aggregation (GO:0070486)4.68859191
16cellular response to interleukin-15 (GO:0071350)4.39650111
17negative regulation of lymphocyte mediated immunity (GO:0002707)4.20491800
18positive regulation by symbiont of host defense response (GO:0052509)4.13872072
19modulation by symbiont of host defense response (GO:0052031)4.13872072
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.13872072
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.13872072
22positive regulation by organism of defense response of other organism involved in symbiotic interact4.13872072
23modulation by symbiont of host immune response (GO:0052553)4.13872072
24activated T cell proliferation (GO:0050798)4.12720441
25regulation of B cell receptor signaling pathway (GO:0050855)4.04494815
26positive thymic T cell selection (GO:0045059)3.94226192
27T cell selection (GO:0045058)3.91425429
28positive T cell selection (GO:0043368)3.86343208
29detection of bacterium (GO:0016045)3.83954016
30thymic T cell selection (GO:0045061)3.82494556
31regulation of T cell tolerance induction (GO:0002664)3.80650509
32detection of other organism (GO:0098543)3.76158410
33negative regulation of leukocyte mediated immunity (GO:0002704)3.67336499
34regulation of tolerance induction (GO:0002643)3.63722588
35negative regulation of T cell mediated immunity (GO:0002710)3.57353299
36positive regulation of tolerance induction (GO:0002645)3.55754307
37signal complex assembly (GO:0007172)3.53505178
38negative regulation of cAMP-mediated signaling (GO:0043951)3.48157012
39positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.42434189
40macrophage activation involved in immune response (GO:0002281)3.34010088
41regulation of T cell mediated cytotoxicity (GO:0001914)3.29118969
42negative regulation of erythrocyte differentiation (GO:0045647)3.27301799
43histone H3-K36 demethylation (GO:0070544)3.25525198
44regulation of interferon-beta biosynthetic process (GO:0045357)3.09762168
45regulation of ARF GTPase activity (GO:0032312)3.08080735
46T cell migration (GO:0072678)3.07645026
47cellular extravasation (GO:0045123)3.06997610
48regulation of natural killer cell mediated immunity (GO:0002715)3.03614129
49regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.03614129
50positive regulation of T cell mediated cytotoxicity (GO:0001916)3.03364985
51B cell receptor signaling pathway (GO:0050853)3.01664725
52regulation of regulatory T cell differentiation (GO:0045589)3.01033837
53regulation of alpha-beta T cell proliferation (GO:0046640)2.98199763
54regulation of ARF protein signal transduction (GO:0032012)2.95760491
55positive regulation of T cell differentiation in thymus (GO:0033089)2.95374546
56regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.94133316
57neutrophil activation involved in immune response (GO:0002283)2.92350199
58positive regulation of histone deacetylation (GO:0031065)2.90105519
59negative regulation of interleukin-6 production (GO:0032715)2.89432344
60negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.89224655
61T cell homeostasis (GO:0043029)2.88877051
62positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.86457200
63negative regulation of phagocytosis (GO:0050765)2.85879449
64natural killer cell differentiation (GO:0001779)2.84250679
65negative regulation of innate immune response (GO:0045824)2.83279724
66response to muramyl dipeptide (GO:0032495)2.80917358
67cilium or flagellum-dependent cell motility (GO:0001539)2.79389997
68negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.77818091
69detection of external biotic stimulus (GO:0098581)2.77194384
70regulation of T-helper 2 cell differentiation (GO:0045628)2.75048442
71negative regulation of interleukin-12 production (GO:0032695)2.74502787
72motile cilium assembly (GO:0044458)2.73217497
73positive regulation of Rap GTPase activity (GO:0032854)2.71629506
74regulation of leukocyte mediated cytotoxicity (GO:0001910)2.67771052
75leukocyte migration involved in inflammatory response (GO:0002523)2.67561886
76positive regulation of granulocyte differentiation (GO:0030854)2.67118945
77response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.66385777
78response to host immune response (GO:0052572)2.66385777
79mast cell activation (GO:0045576)2.66031799
80negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.64907271
81myeloid cell activation involved in immune response (GO:0002275)2.63994397
82neutrophil activation (GO:0042119)2.63958081
83mannose metabolic process (GO:0006013)2.63818002
84regulation of platelet aggregation (GO:0090330)2.61265331
85T cell receptor signaling pathway (GO:0050852)2.60765482
86germinal center formation (GO:0002467)2.59454538
87positive regulation of Cdc42 GTPase activity (GO:0043089)2.58648035
88response to host (GO:0075136)2.57187273
89response to host defenses (GO:0052200)2.57187273
90response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.57187273
91regulation of B cell differentiation (GO:0045577)2.57004237
92Peyers patch development (GO:0048541)2.55880944
93mucosal-associated lymphoid tissue development (GO:0048537)2.55880944
94antigen receptor-mediated signaling pathway (GO:0050851)2.55540891
95regulation of mast cell degranulation (GO:0043304)2.55310020
96positive regulation of mast cell activation (GO:0033005)2.55273000
97regulation of defense response to virus by virus (GO:0050690)2.54961982
98leukocyte degranulation (GO:0043299)2.52146962
99protein targeting to Golgi (GO:0000042)2.48933898
100regulation of granulocyte differentiation (GO:0030852)2.48783176

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.36272408
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.30308020
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.12791973
4RUNX_20019798_ChIP-Seq_JUKART_Human2.95985639
5KDM2B_26808549_Chip-Seq_SUP-B15_Human2.66520306
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.56538158
7MAF_26560356_Chip-Seq_TH1_Human2.42233420
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.40565630
9KDM2B_26808549_Chip-Seq_DND41_Human2.38604174
10VDR_21846776_ChIP-Seq_THP-1_Human2.35323968
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.33658863
12E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.29381497
13UTX_26944678_Chip-Seq_JUKART_Human2.24034134
14MYC_22102868_ChIP-Seq_BL_Human2.22500314
15TCF7_22412390_ChIP-Seq_EML_Mouse2.22085012
16DROSHA_22980978_ChIP-Seq_HELA_Human2.21098686
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.20798793
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.14153345
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.13973203
20LXR_22292898_ChIP-Seq_THP-1_Human2.10713376
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.03147549
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.99166455
23KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.98628643
24SPI1_23127762_ChIP-Seq_K562_Human1.94780918
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.94385836
26MAF_26560356_Chip-Seq_TH2_Human1.92366711
27VDR_24763502_ChIP-Seq_THP-1_Human1.85898879
28MYB_26560356_Chip-Seq_TH2_Human1.85181103
29KDM2B_26808549_Chip-Seq_JURKAT_Human1.84761909
30SCL_19346495_ChIP-Seq_HPC-7_Human1.84470368
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.79594229
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78226157
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.76571520
34GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.72745640
35MYB_26560356_Chip-Seq_TH1_Human1.63517699
36ELF1_20517297_ChIP-Seq_JURKAT_Human1.62412584
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.60614726
38STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.59816858
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.58840971
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57994913
41SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.57698759
42GATA3_27048872_Chip-Seq_THYMUS_Human1.56092769
43BCL6_27268052_Chip-Seq_Bcells_Human1.55203034
44SMC4_20622854_ChIP-Seq_HELA_Human1.54107423
45GATA1_19941827_ChIP-Seq_MEL_Mouse1.53279141
46P68_20966046_ChIP-Seq_HELA_Human1.51104188
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51045618
48KDM2B_26808549_Chip-Seq_K562_Human1.48631107
49SA1_27219007_Chip-Seq_ERYTHROID_Human1.45806442
50EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.41083698
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.36856246
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36379931
53VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.34779632
54NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34597128
55BCOR_27268052_Chip-Seq_Bcells_Human1.34492518
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32556614
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31048548
58EZH2_22144423_ChIP-Seq_EOC_Human1.30130039
59SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.30108511
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28798703
61SPI1_23547873_ChIP-Seq_NB4_Human1.27182494
62PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.25366837
63CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24825807
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24812189
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23249155
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.22205756
67MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21794754
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20102409
69CTCF_27219007_Chip-Seq_Bcells_Human1.19040650
70DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18556369
71GATA1_19941826_ChIP-Seq_K562_Human1.18150413
72OCT4_19829295_ChIP-Seq_ESCs_Human1.16735301
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13793029
74PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11973331
75GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10334283
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10329939
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08594450
78SPI1_20517297_ChIP-Seq_HL60_Human1.08094487
79PHF8_20622854_ChIP-Seq_HELA_Human1.06919278
80STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06584099
81SA1_27219007_Chip-Seq_Bcells_Human1.05666732
82TP63_22573176_ChIP-Seq_HFKS_Human1.05124814
83P300_27268052_Chip-Seq_Bcells_Human1.03503841
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03397181
85CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01642855
86E2F1_20622854_ChIP-Seq_HELA_Human1.00916233
87ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00492793
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99507859
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97889990
90KLF4_19829295_ChIP-Seq_ESCs_Human0.97790545
91VDR_24787735_ChIP-Seq_THP-1_Human0.95848512
92GATA3_26560356_Chip-Seq_TH2_Human0.94524214
93ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91849543
94CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90570222
95YY1_22570637_ChIP-Seq_MALME-3M_Human0.89818340
96CTCF_21964334_ChIP-Seq_BJAB-B_Human0.89057830
97TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.88098838
98CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86742975
99RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86627337
100CTCF_20526341_ChIP-Seq_ESCs_Human0.86555674

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.20541158
2MP0003724_increased_susceptibility_to3.50824356
3MP0003763_abnormal_thymus_physiology3.50804743
4MP0003828_pulmonary_edema3.08913569
5MP0001800_abnormal_humoral_immune2.58438783
6MP0003303_peritoneal_inflammation2.41435715
7MP0005671_abnormal_response_to2.40731962
8MP0003191_abnormal_cellular_cholesterol2.38731086
9MP0004510_myositis2.34838288
10MP0005387_immune_system_phenotype2.26794571
11MP0001790_abnormal_immune_system2.26794571
12MP0005000_abnormal_immune_tolerance2.26761437
13MP0002419_abnormal_innate_immunity2.26620304
14MP0000685_abnormal_immune_system2.24562549
15MP0004084_abnormal_cardiac_muscle2.22820693
16MP0002723_abnormal_immune_serum2.18138862
17MP0002420_abnormal_adaptive_immunity2.17940664
18MP0001819_abnormal_immune_cell2.16263469
19MP0002132_abnormal_respiratory_system2.13147767
20MP0005025_abnormal_response_to2.08490456
21MP0002405_respiratory_system_inflammati2.05047103
22MP0003300_gastrointestinal_ulcer2.01590547
23MP0002452_abnormal_antigen_presenting2.00560344
24MP0001835_abnormal_antigen_presentation1.98016490
25MP0001873_stomach_inflammation1.88360180
26MP0000703_abnormal_thymus_morphology1.77947147
27MP0001533_abnormal_skeleton_physiology1.76944844
28MP0002398_abnormal_bone_marrow1.74849160
29MP0003183_abnormal_peptide_metabolism1.73545339
30MP0006082_CNS_inflammation1.73364042
31MP0004036_abnormal_muscle_relaxation1.70337476
32MP0000716_abnormal_immune_system1.65286301
33MP0004947_skin_inflammation1.63945543
34MP0000465_gastrointestinal_hemorrhage1.61167165
35MP0003172_abnormal_lysosome_physiology1.59088040
36MP0004859_abnormal_synaptic_plasticity1.57746891
37MP0005377_hearing/vestibular/ear_phenot1.54132791
38MP0003878_abnormal_ear_physiology1.54132791
39MP0002933_joint_inflammation1.52797737
40MP0009333_abnormal_splenocyte_physiolog1.47898173
41MP0002722_abnormal_immune_system1.47859079
42MP0009785_altered_susceptibility_to1.45617931
43MP0000689_abnormal_spleen_morphology1.41272686
44MP0005451_abnormal_body_composition1.38650063
45MP0010155_abnormal_intestine_physiology1.37943740
46MP0005310_abnormal_salivary_gland1.36832778
47MP0003866_abnormal_defecation1.36754746
48MP0004130_abnormal_muscle_cell1.34976125
49MP0009840_abnormal_foam_cell1.33936120
50MP0002148_abnormal_hypersensitivity_rea1.31223584
51MP0002009_preneoplasia1.26200818
52MP0004381_abnormal_hair_follicle1.26032187
53MP0008260_abnormal_autophagy1.25442961
54MP0005464_abnormal_platelet_physiology1.22943604
55MP0002998_abnormal_bone_remodeling1.22479413
56MP0002429_abnormal_blood_cell1.21925945
57MP0002127_abnormal_cardiovascular_syste1.17089351
58MP0002396_abnormal_hematopoietic_system1.17073163
59MP0001348_abnormal_lacrimal_gland1.16669789
60MP0004215_abnormal_myocardial_fiber1.15592039
61MP0000749_muscle_degeneration1.14669422
62MP0003279_aneurysm1.13256746
63MP0008004_abnormal_stomach_pH1.12429951
64MP0001845_abnormal_inflammatory_respons1.10424266
65MP0000858_altered_metastatic_potential1.03257386
66MP0005410_abnormal_fertilization1.02845118
67MP0001851_eye_inflammation1.02448037
68MP0001958_emphysema1.00863657
69MP0009278_abnormal_bone_marrow0.98688183
70MP0004484_altered_response_of0.96769538
71MP0002837_dystrophic_cardiac_calcinosis0.90838030
72MP0001879_abnormal_lymphatic_vessel0.90558567
73MP0006138_congestive_heart_failure0.89436233
74MP0002269_muscular_atrophy0.87972293
75MP0001501_abnormal_sleep_pattern0.87669089
76MP0000751_myopathy0.87501504
77MP0003137_abnormal_impulse_conducting0.87421704
78MP0000249_abnormal_blood_vessel0.86632621
79MP0002138_abnormal_hepatobiliary_system0.82925606
80MP0002133_abnormal_respiratory_system0.82518413
81MP0005388_respiratory_system_phenotype0.82518413
82MP0008961_abnormal_basal_metabolism0.81471496
83MP0005666_abnormal_adipose_tissue0.81192737
84MP0008874_decreased_physiological_sensi0.81044992
85MP0008469_abnormal_protein_level0.79499150
86MP0001663_abnormal_digestive_system0.77883893
87MP0003329_amyloid_beta_deposits0.77195806
88MP0005390_skeleton_phenotype0.76616555
89MP0003646_muscle_fatigue0.75111109
90MP0003705_abnormal_hypodermis_morpholog0.74824294
91MP0001986_abnormal_taste_sensitivity0.73876655
92MP0004087_abnormal_muscle_fiber0.73430028
93MP0003879_abnormal_hair_cell0.72116497
94MP0002332_abnormal_exercise_endurance0.70468539
95MP0005623_abnormal_meninges_morphology0.70062509
96MP0000733_abnormal_muscle_development0.69913870
97MP0001544_abnormal_cardiovascular_syste0.69214184
98MP0005385_cardiovascular_system_phenoty0.69214184
99MP0008569_lethality_at_weaning0.68926212
100MP0003690_abnormal_glial_cell0.67062045

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.97434574
2Recurrent abscess formation (HP:0002722)4.26603220
3Recurrent bacterial skin infections (HP:0005406)4.08122364
4Myositis (HP:0100614)4.06423431
5Stomatitis (HP:0010280)3.84266991
6Nasal polyposis (HP:0100582)3.71202741
7Elevated erythrocyte sedimentation rate (HP:0003565)3.58721192
8Increased IgE level (HP:0003212)3.58573135
9Recurrent fungal infections (HP:0002841)3.53233387
10Orchitis (HP:0100796)3.41286876
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.28177105
12Gastrointestinal infarctions (HP:0005244)3.23208740
13Abnormality of the nasal mucosa (HP:0000433)3.21323267
14Spontaneous hematomas (HP:0007420)3.19173323
15Panhypogammaglobulinemia (HP:0003139)3.17633652
16Optic neuritis (HP:0100653)3.15390717
17Retrobulbar optic neuritis (HP:0100654)3.15390717
18Papilledema (HP:0001085)3.11308085
19Recurrent gram-negative bacterial infections (HP:0005420)3.10716582
20Abnormality of macrophages (HP:0004311)3.03306621
21Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.03133465
22Dynein arm defect of respiratory motile cilia (HP:0012255)2.99391757
23Absent/shortened dynein arms (HP:0200106)2.99391757
24Meningitis (HP:0001287)2.87726614
25Chronic obstructive pulmonary disease (HP:0006510)2.79874570
26Obstructive lung disease (HP:0006536)2.79874570
27Aortic aneurysm (HP:0004942)2.74704604
28Recurrent skin infections (HP:0001581)2.74434073
29T lymphocytopenia (HP:0005403)2.73589128
30Pustule (HP:0200039)2.73451585
31Encephalitis (HP:0002383)2.69145701
32Recurrent cutaneous fungal infections (HP:0011370)2.67659766
33Chronic mucocutaneous candidiasis (HP:0002728)2.67659766
34Ventricular tachycardia (HP:0004756)2.66752468
35Prolonged bleeding time (HP:0003010)2.65487397
36Cellulitis (HP:0100658)2.63741397
37Mediastinal lymphadenopathy (HP:0100721)2.62515994
38Chest pain (HP:0100749)2.60464384
39Gingivitis (HP:0000230)2.60145940
40Recurrent sinusitis (HP:0011108)2.58428097
41Abnormal ciliary motility (HP:0012262)2.54762134
42Abnormal respiratory motile cilium morphology (HP:0005938)2.50958165
43Abnormal respiratory epithelium morphology (HP:0012253)2.50958165
44Gastrointestinal inflammation (HP:0004386)2.49800438
45Hypochromic microcytic anemia (HP:0004840)2.49245829
46Inflammation of the large intestine (HP:0002037)2.48148799
47Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.48106072
48Hypochromic anemia (HP:0001931)2.47364974
49Abnormality of T cell number (HP:0011839)2.47262694
50Abnormal respiratory motile cilium physiology (HP:0012261)2.47158661
51Obstructive sleep apnea (HP:0002870)2.46363465
52Severe combined immunodeficiency (HP:0004430)2.42583711
53Lymphopenia (HP:0001888)2.40914808
54Sudden death (HP:0001699)2.37911602
55Vasculitis (HP:0002633)2.36221130
56Exercise-induced myalgia (HP:0003738)2.32576277
57Abnormality of T cells (HP:0002843)2.25935544
58Peritonitis (HP:0002586)2.24223257
59Leukocytosis (HP:0001974)2.22367409
60Bronchiectasis (HP:0002110)2.21806136
61Abnormality of cells of the lymphoid lineage (HP:0012140)2.18120793
62Asymmetric septal hypertrophy (HP:0001670)2.16052262
63Papilloma (HP:0012740)2.15501765
64Verrucae (HP:0200043)2.15501765
65Colitis (HP:0002583)2.14800459
66Infertility (HP:0000789)2.14379623
67Abnormality of the fingertips (HP:0001211)2.13495184
68Annular pancreas (HP:0001734)2.12822111
69Hemoptysis (HP:0002105)2.10740930
70Keratoconjunctivitis sicca (HP:0001097)2.07862229
71Keratoconjunctivitis (HP:0001096)2.07845926
72Metaphyseal cupping (HP:0003021)2.05526725
73Difficulty running (HP:0009046)2.04220131
74Episodic fever (HP:0001954)2.03216938
75Muscle fiber splitting (HP:0003555)2.02788919
76Recurrent otitis media (HP:0000403)2.00717576
77Hemiplegia (HP:0002301)2.00316601
78Gastrointestinal stroma tumor (HP:0100723)1.97515594
79Hematochezia (HP:0002573)1.97492865
80Slow saccadic eye movements (HP:0000514)1.96684707
81Epistaxis (HP:0000421)1.95811320
82Neoplasm of the heart (HP:0100544)1.95264362
83Granulocytopenia (HP:0001913)1.95199117
84Asymmetry of the thorax (HP:0001555)1.94425950
85Easy fatigability (HP:0003388)1.93758705
86Global brain atrophy (HP:0002283)1.93667454
87Urticaria (HP:0001025)1.92899421
88Combined immunodeficiency (HP:0005387)1.89468690
89Hyporeflexia of lower limbs (HP:0002600)1.89280830
90Cerebral aneurysm (HP:0004944)1.88193509
91Increased variability in muscle fiber diameter (HP:0003557)1.87238677
92Emphysema (HP:0002097)1.86699935
93Pulmonary infiltrates (HP:0002113)1.83748629
94Recurrent bronchitis (HP:0002837)1.83551843
95Postural instability (HP:0002172)1.82214230
96Aneurysm (HP:0002617)1.81604611
97Thoracic kyphosis (HP:0002942)1.81171399
98Abnormality of the endocardium (HP:0004306)1.80626286
99Diplopia (HP:0000651)1.79518008
100Abnormality of binocular vision (HP:0011514)1.79518008

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.31304670
2RIPK43.03795077
3PRPF4B2.68233044
4FES2.57626970
5TYK22.43155918
6TNK22.10279982
7CSK2.06008160
8MAP2K32.01132148
9ZAP701.96124205
10TRIB31.93023272
11GRK61.87445421
12CDC42BPA1.83626436
13SIK21.80578614
14EPHB11.78898572
15HCK1.75851563
16ERN11.67888529
17SMG11.66939241
18JAK31.64388242
19INSRR1.63679425
20IRAK41.61964234
21MAP3K111.60947642
22BLK1.54005271
23MARK21.52329491
24TAOK11.50368190
25MAP3K101.47503798
26JAK11.46867939
27MAP3K131.46547530
28PTK2B1.44377145
29BTK1.39222445
30TAOK31.38241842
31KSR21.37881525
32PTK61.36298723
33CSF1R1.32384724
34RIPK11.31765816
35CAMKK11.30301215
36MAP3K31.29230450
37PRKD21.28180256
38DYRK1B1.24107656
39SYK1.22632728
40PRKD31.19901796
41PRKG21.18853984
42MAPK121.17367989
43FGR1.16090743
44ITK1.14415083
45PDK11.11293384
46FGFR41.08920718
47CDK191.08728261
48UHMK11.08504602
49LCK1.07427266
50CDK121.04724549
51TYRO31.04684006
52MAP3K71.03647705
53EPHA41.01125981
54SIK30.99962307
55HIPK20.98081798
56TXK0.95327891
57JAK20.94043024
58TBK10.94031370
59STK110.91800459
60PDPK10.91174861
61STK380.90539010
62PRKCH0.88771164
63ICK0.86494782
64MAP3K50.86215056
65IKBKE0.84609771
66MAP3K10.80717357
67LYN0.80699472
68MAPK70.77930779
69PASK0.76964072
70RET0.75933982
71MAP2K20.73182479
72TIE10.72991083
73BRD40.70871700
74MAPK150.68802669
75DAPK20.66730962
76NLK0.66048154
77SIK10.65447345
78PRKCQ0.60943601
79BMX0.59159112
80FGFR30.57887166
81PAK60.57801992
82CAMKK20.56260652
83FYN0.53869914
84MARK30.52440154
85TAOK20.52315510
86CDK40.49996007
87RPS6KA20.48968993
88STK100.48142572
89PDGFRB0.48013539
90KDR0.46038243
91CAMK40.44267783
92MELK0.43012712
93SGK30.42335242
94NTRK20.40822480
95TTN0.38879477
96ROCK10.38555411
97TEC0.38154855
98MAPK110.38035639
99RPS6KC10.37893471
100RPS6KL10.37893471

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.58883422
2Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.14423485
3Osteoclast differentiation_Homo sapiens_hsa043802.08255236
4T cell receptor signaling pathway_Homo sapiens_hsa046601.96066726
5B cell receptor signaling pathway_Homo sapiens_hsa046621.91085216
6Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.86242592
7Acute myeloid leukemia_Homo sapiens_hsa052211.75957121
8VEGF signaling pathway_Homo sapiens_hsa043701.61298185
9Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.60825126
10Graft-versus-host disease_Homo sapiens_hsa053321.51796378
11Non-small cell lung cancer_Homo sapiens_hsa052231.50348303
12Leishmaniasis_Homo sapiens_hsa051401.46362906
13Chemokine signaling pathway_Homo sapiens_hsa040621.43159023
14Notch signaling pathway_Homo sapiens_hsa043301.42648117
15Phosphatidylinositol signaling system_Homo sapiens_hsa040701.40134409
16Allograft rejection_Homo sapiens_hsa053301.40033059
17Leukocyte transendothelial migration_Homo sapiens_hsa046701.33344133
18Autoimmune thyroid disease_Homo sapiens_hsa053201.31338234
19Viral myocarditis_Homo sapiens_hsa054161.31151180
20Platelet activation_Homo sapiens_hsa046111.29523415
21Phospholipase D signaling pathway_Homo sapiens_hsa040721.27608637
22Measles_Homo sapiens_hsa051621.26071334
23Choline metabolism in cancer_Homo sapiens_hsa052311.21518320
24Chronic myeloid leukemia_Homo sapiens_hsa052201.18655099
25Inositol phosphate metabolism_Homo sapiens_hsa005621.16314706
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.15031151
27Tuberculosis_Homo sapiens_hsa051521.13755762
28Hematopoietic cell lineage_Homo sapiens_hsa046401.13198265
29Long-term potentiation_Homo sapiens_hsa047201.12154571
30Dilated cardiomyopathy_Homo sapiens_hsa054141.07528234
31Malaria_Homo sapiens_hsa051441.06415033
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05044071
33Cholinergic synapse_Homo sapiens_hsa047251.03409497
34Pancreatic cancer_Homo sapiens_hsa052121.02778294
35Staphylococcus aureus infection_Homo sapiens_hsa051501.02353565
36Endocytosis_Homo sapiens_hsa041440.99826412
37MAPK signaling pathway_Homo sapiens_hsa040100.99254795
38Toll-like receptor signaling pathway_Homo sapiens_hsa046200.99195378
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98239141
40Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98197688
41GnRH signaling pathway_Homo sapiens_hsa049120.98089446
42Glycerophospholipid metabolism_Homo sapiens_hsa005640.94113152
43NF-kappa B signaling pathway_Homo sapiens_hsa040640.93724215
44Endometrial cancer_Homo sapiens_hsa052130.93716734
45Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93469208
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.92685527
47Gastric acid secretion_Homo sapiens_hsa049710.92540043
48Oxytocin signaling pathway_Homo sapiens_hsa049210.92376331
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92105532
50Antigen processing and presentation_Homo sapiens_hsa046120.91619358
51Circadian entrainment_Homo sapiens_hsa047130.91185667
52Hepatitis B_Homo sapiens_hsa051610.91059887
53Neurotrophin signaling pathway_Homo sapiens_hsa047220.90469904
54Renal cell carcinoma_Homo sapiens_hsa052110.89831304
55Type I diabetes mellitus_Homo sapiens_hsa049400.88755855
56Salivary secretion_Homo sapiens_hsa049700.88390913
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87844289
58Influenza A_Homo sapiens_hsa051640.87329449
59Toxoplasmosis_Homo sapiens_hsa051450.86412544
60Morphine addiction_Homo sapiens_hsa050320.86128507
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85462522
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85407998
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83517533
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83382186
65Colorectal cancer_Homo sapiens_hsa052100.83287627
66Glioma_Homo sapiens_hsa052140.82335541
67Rap1 signaling pathway_Homo sapiens_hsa040150.81837373
68Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.81005732
69TNF signaling pathway_Homo sapiens_hsa046680.80363001
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.80095973
71mTOR signaling pathway_Homo sapiens_hsa041500.79343699
72ErbB signaling pathway_Homo sapiens_hsa040120.77297034
73Pancreatic secretion_Homo sapiens_hsa049720.76938546
74Estrogen signaling pathway_Homo sapiens_hsa049150.76906506
75Herpes simplex infection_Homo sapiens_hsa051680.76143485
76Ras signaling pathway_Homo sapiens_hsa040140.75818902
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75449175
78Calcium signaling pathway_Homo sapiens_hsa040200.75160092
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74683759
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73170269
81FoxO signaling pathway_Homo sapiens_hsa040680.72830637
82Hepatitis C_Homo sapiens_hsa051600.71630769
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70476604
84HTLV-I infection_Homo sapiens_hsa051660.68854892
85cAMP signaling pathway_Homo sapiens_hsa040240.68440186
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65324338
87Apoptosis_Homo sapiens_hsa042100.65084836
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.64654743
89Prolactin signaling pathway_Homo sapiens_hsa049170.64475290
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63413900
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63387854
92African trypanosomiasis_Homo sapiens_hsa051430.63115900
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62982591
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62503830
95Type II diabetes mellitus_Homo sapiens_hsa049300.60589250
96Olfactory transduction_Homo sapiens_hsa047400.58957339
97Focal adhesion_Homo sapiens_hsa045100.57300429
98Melanogenesis_Homo sapiens_hsa049160.57105814
99Dorso-ventral axis formation_Homo sapiens_hsa043200.56932032
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55940063

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