ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	surfactant homeostasis (GO:0043129)	9.67218583
2	chemical homeostasis within a tissue (GO:0048875)	7.65624704
3	positive regulation of endothelial cell differentiation (GO:0045603)	6.39122881
4	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	5.73618708
5	regulation of endothelial cell differentiation (GO:0045601)	5.42085346
6	cellular response to nitric oxide (GO:0071732)	5.32455386
7	plasma membrane fusion (GO:0045026)	5.22728980
8	regulation of cardioblast differentiation (GO:0051890)	4.84176159
9	positive regulation of gastrulation (GO:2000543)	4.73174366
10	fusion of sperm to egg plasma membrane (GO:0007342)	4.66332012
11	sperm motility (GO:0030317)	4.60900094
12	acrosome reaction (GO:0007340)	4.57269376
13	positive regulation of action potential (GO:0045760)	4.41337940
14	glomerulus development (GO:0032835)	4.32576273
15	regulation of hippo signaling (GO:0035330)	4.22289996
16	regulation of integrin-mediated signaling pathway (GO:2001044)	4.03462643
17	endothelial cell chemotaxis (GO:0035767)	3.95572930
18	respiratory gaseous exchange (GO:0007585)	3.89459504
19	regulation of glomerular filtration (GO:0003093)	3.77779925
20	cellular response to reactive nitrogen species (GO:1902170)	3.77497298
21	regulation of vasculogenesis (GO:2001212)	3.77313106
22	atrioventricular valve morphogenesis (GO:0003181)	3.76304211
23	cellular response to electrical stimulus (GO:0071257)	3.68964270
24	lymphangiogenesis (GO:0001946)	3.63974222
25	artery development (GO:0060840)	3.55694993
26	sexual reproduction (GO:0019953)	3.52945498
27	response to BMP (GO:0071772)	3.47654897
28	cellular response to BMP stimulus (GO:0071773)	3.47654897
29	head development (GO:0060322)	3.47152078
30	multicellular organismal movement (GO:0050879)	3.42725359
31	musculoskeletal movement (GO:0050881)	3.42725359
32	sperm capacitation (GO:0048240)	3.41920742
33	negative regulation of Rho protein signal transduction (GO:0035024)	3.40765466
34	response to nitric oxide (GO:0071731)	3.33296735
35	tachykinin receptor signaling pathway (GO:0007217)	3.29192094
36	regulation of p38MAPK cascade (GO:1900744)	3.27361214
37	cell migration involved in sprouting angiogenesis (GO:0002042)	3.20054488
38	spermatid development (GO:0007286)	3.18135771
39	negative regulation of axon guidance (GO:1902668)	3.17809317
40	myoblast fusion (GO:0007520)	3.17490832
41	positive regulation of digestive system process (GO:0060456)	3.17178241
42	single strand break repair (GO:0000012)	3.14590364
43	spinal cord association neuron differentiation (GO:0021527)	3.11399102
44	RNA destabilization (GO:0050779)	3.10977090
45	positive regulation of protein kinase C signaling (GO:0090037)	3.10198893
46	lymph vessel development (GO:0001945)	3.09792168
47	cilium or flagellum-dependent cell motility (GO:0001539)	3.08732984
48	regulation of axon guidance (GO:1902667)	2.98838752
49	syncytium formation by plasma membrane fusion (GO:0000768)	2.96160584
50	camera-type eye morphogenesis (GO:0048593)	2.96063602
51	negative regulation of complement activation (GO:0045916)	2.89697685
52	reproduction (GO:0000003)	2.87207584
53	axon extension involved in axon guidance (GO:0048846)	2.84439940
54	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.84439940
55	neuron remodeling (GO:0016322)	2.82316988
56	endothelial cell differentiation (GO:0045446)	2.81224187
57	regulation of transcription involved in cell fate commitment (GO:0060850)	2.79826328
58	glomerular basement membrane development (GO:0032836)	2.79551151
59	extracellular matrix assembly (GO:0085029)	2.78985241
60	metanephric epithelium development (GO:0072207)	2.78742551
61	outflow tract septum morphogenesis (GO:0003148)	2.77749432
62	multicellular organism reproduction (GO:0032504)	2.77018620
63	positive regulation of vasculogenesis (GO:2001214)	2.76939432
64	induction of positive chemotaxis (GO:0050930)	2.75022069
65	cell differentiation in spinal cord (GO:0021515)	2.73941142
66	endocardial cushion development (GO:0003197)	2.73627709
67	regulation of action potential (GO:0098900)	2.73044234
68	peptide catabolic process (GO:0043171)	2.72592257
69	regulation of cardioblast proliferation (GO:0003264)	2.71568018
70	regulation of secondary heart field cardioblast proliferation (GO:0003266)	2.71568018
71	cerebral cortex neuron differentiation (GO:0021895)	2.71086418
72	spermatid nucleus differentiation (GO:0007289)	2.70711329
73	response to vitamin A (GO:0033189)	2.69246614
74	cellular response to vascular endothelial growth factor stimulus (GO:0035924)	2.68765409
75	hormone catabolic process (GO:0042447)	2.66166264
76	syncytium formation (GO:0006949)	2.65550330
77	metanephric mesenchyme development (GO:0072075)	2.65374469
78	vascular endothelial growth factor signaling pathway (GO:0038084)	2.63813695
79	DNA packaging (GO:0006323)	2.61713576
80	metanephric nephron epithelium development (GO:0072243)	2.60784657
81	embryonic viscerocranium morphogenesis (GO:0048703)	2.59921914
82	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	2.58411361
83	chromosome condensation (GO:0030261)	2.57769096
84	one-carbon compound transport (GO:0019755)	2.56400796
85	embryonic foregut morphogenesis (GO:0048617)	2.56254595
86	negative regulation of chondrocyte differentiation (GO:0032331)	2.54635810
87	response to pheromone (GO:0019236)	2.54528601
88	trivalent inorganic anion homeostasis (GO:0072506)	2.53928929
89	phosphate ion homeostasis (GO:0055062)	2.53928929
90	coronary vasculature morphogenesis (GO:0060977)	2.53091541
91	protein targeting to Golgi (GO:0000042)	2.52832107
92	endothelial cell morphogenesis (GO:0001886)	2.52695639
93	microtubule depolymerization (GO:0007019)	2.51963279
94	establishment of protein localization to Golgi (GO:0072600)	2.51513610
95	microtubule severing (GO:0051013)	2.51329457
96	sequestering of actin monomers (GO:0042989)	2.50871936
97	negative regulation of protein localization to cell surface (GO:2000009)	2.50581864
98	blood vessel remodeling (GO:0001974)	2.50567410
99	regulation of axon extension involved in axon guidance (GO:0048841)	2.50334217
100	negative regulation of protein activation cascade (GO:2000258)	2.49885107

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	2.83300073
2	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.42177331
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.34938649
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.33066295
5	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.28714465
6	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.04369704
7	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	2.03340999
8	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.94962712
9	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.86195234
10	DROSHA_22980978_ChIP-Seq_HELA_Human	1.85694082
11	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.69911760
12	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.66190446
13	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.65792561
14	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.63451448
15	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.62302645
16	CTCF_27219007_Chip-Seq_Bcells_Human	1.57074129
17	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.57057529
18	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.57057529
19	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.56017003
20	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.55328906
21	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.55187517
22	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.55072702
23	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.53642813
24	TAF15_26573619_Chip-Seq_HEK293_Human	1.52231163
25	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.51461425
26	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.50462265
27	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.49978574
28	AHR_22903824_ChIP-Seq_MCF-7_Human	1.49650709
29	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.49174209
30	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.48777330
31	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.48730676
32	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.47499977
33	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.45633183
34	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.45588336
35	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.41486576
36	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.37704687
37	CJUN_26792858_Chip-Seq_BT549_Human	1.37352202
38	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.35268685
39	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.34046488
40	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.33268805
41	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.32967156
42	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.30841076
43	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.28811683
44	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.26125983
45	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.23230387
46	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23230387
47	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.22073339
48	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.21481859
49	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.20323865
50	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.19061594
51	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.18584359
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.18584359
53	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.17551021
54	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.16295690
55	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.15221079
56	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.14487138
57	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.13577255
58	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.12918891
59	LXR_22292898_ChIP-Seq_THP-1_Human	1.09628995
60	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.08553712
61	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.07286924
62	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.03927760
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.03692015
64	ISL1_27105846_Chip-Seq_CPCs_Mouse	1.03431697
65	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	1.02335194
66	GATA1_22025678_ChIP-Seq_K562_Human	1.01469749
67	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.00867288
68	SMAD4_21799915_ChIP-Seq_A2780_Human	1.00332644
69	FUS_26573619_Chip-Seq_HEK293_Human	0.99999018
70	KDM2B_26808549_Chip-Seq_SUP-B15_Human	0.99952679
71	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.99935670
72	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.99235682
73	TP53_18474530_ChIP-ChIP_U2OS_Human	0.96278372
74	KDM2B_26808549_Chip-Seq_REH_Human	0.95563956
75	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.95095543
76	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.94726306
77	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.94468504
78	KLF5_25053715_ChIP-Seq_YYC3_Human	0.94188877
79	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.93300793
80	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.92719091
81	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.92635991
82	TP53_22127205_ChIP-Seq_IMR90_Human	0.91365047
83	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.91182839
84	KDM2B_26808549_Chip-Seq_K562_Human	0.91132952
85	ERA_21632823_ChIP-Seq_H3396_Human	0.91098244
86	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.90884960
87	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.90884960
88	VDR_22108803_ChIP-Seq_LS180_Human	0.90867424
89	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.89881206
90	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.89253579
91	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.87255455
92	RXR_22108803_ChIP-Seq_LS180_Human	0.86927564
93	TP63_22573176_ChIP-Seq_HFKS_Human	0.86854148
94	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.86816889
95	AR_21572438_ChIP-Seq_LNCaP_Human	0.86530922
96	STAT3_23295773_ChIP-Seq_U87_Human	0.86297420
97	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.84759037
98	AR_25329375_ChIP-Seq_VCAP_Human	0.84579227
99	TP53_23651856_ChIP-Seq_MEFs_Mouse	0.84295836
100	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.84182413

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004782_abnormal_surfactant_physiolog	6.48698369
2	MP0001958_emphysema	5.08697239
3	MP0008995_early_reproductive_senescence	4.64209987
4	MP0005410_abnormal_fertilization	4.41977270
5	MP0010368_abnormal_lymphatic_system	3.57898797
6	MP0001879_abnormal_lymphatic_vessel	2.46718956
7	MP0001542_abnormal_bone_strength	2.39616096
8	MP0003091_abnormal_cell_migration	2.30478607
9	MP0001986_abnormal_taste_sensitivity	2.21703167
10	MP0008438_abnormal_cutaneous_collagen	2.21341442
11	MP0005388_respiratory_system_phenotype	2.02050127
12	MP0002133_abnormal_respiratory_system	2.02050127
13	MP0006138_congestive_heart_failure	1.94523659
14	MP0005377_hearing/vestibular/ear_phenot	1.84339204
15	MP0003878_abnormal_ear_physiology	1.84339204
16	MP0004272_abnormal_basement_membrane	1.84096069
17	MP0001968_abnormal_touch/_nociception	1.78929512
18	MP0002249_abnormal_larynx_morphology	1.78859811
19	MP0000534_abnormal_ureter_morphology	1.78675076
20	MP0005275_abnormal_skin_tensile	1.76235411
21	MP0005670_abnormal_white_adipose	1.73144839
22	MP0010386_abnormal_urinary_bladder	1.70625885
23	MP0004883_abnormal_blood_vessel	1.69962411
24	MP0003283_abnormal_digestive_organ	1.67322244
25	MP0004084_abnormal_cardiac_muscle	1.66121564
26	MP0005595_abnormal_vascular_smooth	1.65734369
27	MP0003279_aneurysm	1.60558084
28	MP0003950_abnormal_plasma_membrane	1.57676262
29	MP0005083_abnormal_biliary_tract	1.57497377
30	MP0000049_abnormal_middle_ear	1.47986602
31	MP0005167_abnormal_blood-brain_barrier	1.41282874
32	MP0000013_abnormal_adipose_tissue	1.40564139
33	MP0003566_abnormal_cell_adhesion	1.40365966
34	MP0002295_abnormal_pulmonary_circulatio	1.38412365
35	MP0005503_abnormal_tendon_morphology	1.36757601
36	MP0001177_atelectasis	1.36399687
37	MP0008775_abnormal_heart_ventricle	1.32158455
38	MP0001756_abnormal_urination	1.29502566
39	MP0005164_abnormal_response_to	1.29013354
40	MP0002733_abnormal_thermal_nociception	1.27164368
41	MP0004085_abnormal_heartbeat	1.25821635
42	MP0003698_abnormal_male_reproductive	1.25738713
43	MP0003705_abnormal_hypodermis_morpholog	1.25376774
44	MP0003828_pulmonary_edema	1.22248765
45	MP0009384_cardiac_valve_regurgitation	1.21730025
46	MP0000767_abnormal_smooth_muscle	1.20439670
47	MP0002102_abnormal_ear_morphology	1.19237970
48	MP0000751_myopathy	1.18894459
49	MP0003942_abnormal_urinary_system	1.18122550
50	MP0010030_abnormal_orbit_morphology	1.15740577
51	MP0003115_abnormal_respiratory_system	1.13535024
52	MP0001175_abnormal_lung_morphology	1.12086920
53	MP0002736_abnormal_nociception_after	1.11050480
54	MP0008004_abnormal_stomach_pH	1.09506285
55	MP0001485_abnormal_pinna_reflex	1.07468079
56	MP0003879_abnormal_hair_cell	1.06446296
57	MP0002822_catalepsy	1.06304091
58	MP0002925_abnormal_cardiovascular_devel	1.05001325
59	MP0002127_abnormal_cardiovascular_syste	1.01220511
60	MP0001440_abnormal_grooming_behavior	1.00217107
61	MP0001614_abnormal_blood_vessel	0.92797441
62	MP0003786_premature_aging	0.92779032
63	MP0000249_abnormal_blood_vessel	0.92315912
64	MP0002128_abnormal_blood_circulation	0.90737740
65	MP0003122_maternal_imprinting	0.90673834
66	MP0000026_abnormal_inner_ear	0.89886068
67	MP0000749_muscle_degeneration	0.89850023
68	MP0002933_joint_inflammation	0.85284615
69	MP0005171_absent_coat_pigmentation	0.85035901
70	MP0005248_abnormal_Harderian_gland	0.83626839
71	MP0000955_abnormal_spinal_cord	0.81871591
72	MP0000678_abnormal_parathyroid_gland	0.80353277
73	MP0003385_abnormal_body_wall	0.80131521
74	MP0003137_abnormal_impulse_conducting	0.76125714
75	MP0003252_abnormal_bile_duct	0.75955096
76	MP0002161_abnormal_fertility/fecundity	0.75452278
77	MP0001299_abnormal_eye_distance/	0.73436539
78	MP0001544_abnormal_cardiovascular_syste	0.73116188
79	MP0005385_cardiovascular_system_phenoty	0.73116188
80	MP0005423_abnormal_somatic_nervous	0.72795378
81	MP0005330_cardiomyopathy	0.72539266
82	MP0001929_abnormal_gametogenesis	0.72124990
83	MP0005620_abnormal_muscle_contractility	0.71558719
84	MP0001963_abnormal_hearing_physiology	0.67237525
85	MP0001851_eye_inflammation	0.67051460
86	MP0002972_abnormal_cardiac_muscle	0.67012437
87	MP0002282_abnormal_trachea_morphology	0.66548116
88	MP0004036_abnormal_muscle_relaxation	0.66505728
89	MP0002108_abnormal_muscle_morphology	0.66488878
90	MP0000566_synostosis	0.65872535
91	MP0005023_abnormal_wound_healing	0.65482148
92	MP0004215_abnormal_myocardial_fiber	0.64244232
93	MP0004742_abnormal_vestibular_system	0.61687069
94	MP0009250_abnormal_appendicular_skeleto	0.61661621
95	MP0001784_abnormal_fluid_regulation	0.61495070
96	MP0002332_abnormal_exercise_endurance	0.60851740
97	MP0008789_abnormal_olfactory_epithelium	0.60120233
98	MP0002557_abnormal_social/conspecific_i	0.59539760
99	MP0002138_abnormal_hepatobiliary_system	0.58142915
100	MP0001943_abnormal_respiration	0.58095216

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Interstitial pulmonary disease (HP:0006530)	9.76108789
2	Respiratory distress (HP:0002098)	4.43977105
3	Tachypnea (HP:0002789)	4.37439338
4	Aplasia of the musculature (HP:0100854)	3.56239512
5	Tubulointerstitial fibrosis (HP:0005576)	3.55860930
6	Genetic anticipation (HP:0003743)	3.49712483
7	Decreased circulating renin level (HP:0003351)	3.36720869
8	Abnormality of the fingertips (HP:0001211)	3.18665195
9	Patent foramen ovale (HP:0001655)	3.15248323
10	Thin ribs (HP:0000883)	3.03787222
11	Popliteal pterygium (HP:0009756)	3.00567011
12	Asymmetric septal hypertrophy (HP:0001670)	3.00330244
13	Tubulointerstitial abnormality (HP:0001969)	2.82884872
14	Pulmonary artery stenosis (HP:0004415)	2.81268663
15	Aortic aneurysm (HP:0004942)	2.77537144
16	Shawl scrotum (HP:0000049)	2.76906512
17	Mesangial abnormality (HP:0001966)	2.76512487
18	Bell-shaped thorax (HP:0001591)	2.74553778
19	Horizontal nystagmus (HP:0000666)	2.70015120
20	Chronic hepatic failure (HP:0100626)	2.67394039
21	Alveolar cell carcinoma (HP:0006519)	2.66803901
22	Ulnar claw (HP:0001178)	2.60949773
23	Pulmonary hypertension (HP:0002092)	2.59069283
24	Hypoplastic heart (HP:0001961)	2.48390297
25	Hyperkalemia (HP:0002153)	2.44839880
26	Clumsiness (HP:0002312)	2.39758472
27	Adactyly (HP:0009776)	2.38914155
28	Abnormality of the renal collecting system (HP:0004742)	2.38214371
29	Neoplasm of the tracheobronchial system (HP:0100552)	2.37132948
30	Abnormality of the ischium (HP:0003174)	2.35442032
31	Occipital encephalocele (HP:0002085)	2.35372767
32	Abnormality of the hepatic vasculature (HP:0006707)	2.34931257
33	Bronchomalacia (HP:0002780)	2.34271925
34	Portal hypertension (HP:0001409)	2.34088031
35	Flat capital femoral epiphysis (HP:0003370)	2.27615567
36	Camptodactyly of toe (HP:0001836)	2.26957183
37	Stage 5 chronic kidney disease (HP:0003774)	2.25643562
38	Progressive cerebellar ataxia (HP:0002073)	2.25438743
39	Exertional dyspnea (HP:0002875)	2.23111260
40	Increased connective tissue (HP:0009025)	2.22651818
41	Potter facies (HP:0002009)	2.20926727
42	Facial shape deformation (HP:0011334)	2.20926727
43	Mitral valve prolapse (HP:0001634)	2.20119357
44	Malignant hyperthermia (HP:0002047)	2.19001312
45	Neonatal respiratory distress (HP:0002643)	2.15685792
46	Short 4th metacarpal (HP:0010044)	2.15527525
47	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.15527525
48	Bicornuate uterus (HP:0000813)	2.14210033
49	Shallow orbits (HP:0000586)	2.11781365
50	Tubulointerstitial nephritis (HP:0001970)	2.11575793
51	Lymphangioma (HP:0100764)	2.09028427
52	Polycythemia (HP:0001901)	2.08423735
53	Cerebral palsy (HP:0100021)	2.07398626
54	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.07318868
55	Vascular tortuosity (HP:0004948)	2.05505453
56	Segmental peripheral demyelination/remyelination (HP:0003481)	2.04805250
57	Cerebral aneurysm (HP:0004944)	2.04602657
58	Thyroid-stimulating hormone excess (HP:0002925)	2.03299559
59	Myotonia (HP:0002486)	2.02556971
60	Absent hand (HP:0004050)	1.97257853
61	Fetal akinesia sequence (HP:0001989)	1.97150622
62	Attenuation of retinal blood vessels (HP:0007843)	1.95289596
63	Rectal prolapse (HP:0002035)	1.93764310
64	Bradycardia (HP:0001662)	1.93658156
65	Protrusio acetabuli (HP:0003179)	1.88374871
66	Renal dysplasia (HP:0000110)	1.87056637
67	Ulnar deviation of the wrist (HP:0003049)	1.85921094
68	Morphological abnormality of the middle ear (HP:0008609)	1.84755986
69	Hypoplastic ischia (HP:0003175)	1.84018248
70	Abnormality of the aortic arch (HP:0012303)	1.83469025
71	Sprengel anomaly (HP:0000912)	1.82443431
72	Type 2 muscle fiber atrophy (HP:0003554)	1.81463534
73	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.81006680
74	Neoplasm of the heart (HP:0100544)	1.80951466
75	Focal segmental glomerulosclerosis (HP:0000097)	1.80634553
76	Joint stiffness (HP:0001387)	1.80614702
77	Annular pancreas (HP:0001734)	1.77239829
78	Amniotic constriction ring (HP:0009775)	1.77007837
79	Abnormality of placental membranes (HP:0011409)	1.77007837
80	Disproportionate tall stature (HP:0001519)	1.76733227
81	Absent epiphyses (HP:0010577)	1.76079788
82	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.76079788
83	Abnormal pancreas size (HP:0012094)	1.73651299
84	Bony spicule pigmentary retinopathy (HP:0007737)	1.73624757
85	Flexion contracture of toe (HP:0005830)	1.73423942
86	Joint contractures involving the joints of the feet (HP:0100492)	1.73423942
87	Esophageal varix (HP:0002040)	1.71674082
88	Midline defect of the nose (HP:0004122)	1.71246867
89	Rib fusion (HP:0000902)	1.71234239
90	Aortic dissection (HP:0002647)	1.70807308
91	Abnormality of the left ventricular outflow tract (HP:0011103)	1.69732249
92	Subaortic stenosis (HP:0001682)	1.69732249
93	Muscle fiber splitting (HP:0003555)	1.69439201
94	Abnormality of the neuromuscular junction (HP:0003398)	1.69361740
95	Fatigable weakness (HP:0003473)	1.69361740
96	Dysdiadochokinesis (HP:0002075)	1.68991889
97	Arterial tortuosity (HP:0005116)	1.68489270
98	Ectopia lentis (HP:0001083)	1.68319913
99	Aplasia of the phalanges of the hand (HP:0009802)	1.64676686
100	Aplasia involving bones of the extremities (HP:0009825)	1.64676686

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TIE1	4.29200932
2	MAPK15	3.56148226
3	DDR2	3.50491987
4	PLK4	3.27710788
5	TGFBR2	2.67203100
6	TESK1	2.65820359
7	STK38L	2.30199607
8	RPS6KA2	2.24881642
9	RIPK1	2.23378353
10	STK38	2.16799725
11	LATS1	2.13913035
12	MARK2	2.03815969
13	AKT3	1.98810943
14	KDR	1.96957503
15	DYRK1B	1.79045229
16	BCR	1.75842763
17	TNIK	1.67146145
18	MARK1	1.65856786
19	EPHB1	1.46612098
20	NEK9	1.41716231
21	SGK223	1.41491802
22	SGK494	1.41491802
23	SGK2	1.36124208
24	DAPK2	1.35152064
25	MAP4K2	1.32242601
26	RPS6KL1	1.31749141
27	RPS6KC1	1.31749141
28	MAP3K7	1.29163318
29	PRKD3	1.28893144
30	WNK1	1.26215310
31	DYRK3	1.24096836
32	RPS6KA6	1.22582412
33	PDPK1	1.18456812
34	MAP3K6	1.16833337
35	MYLK	1.14904152
36	CDK12	1.09918037
37	BRD4	1.07792191
38	CDC42BPA	1.06475165
39	MAP3K4	1.06162502
40	PRKD2	0.98515521
41	PKN2	0.97211377
42	PDGFRA	0.96702719
43	LATS2	0.96036303
44	FGFR4	0.96029442
45	INSRR	0.95912598
46	NME1	0.95790942
47	PIK3CG	0.93998335
48	PRKD1	0.88773857
49	SGK3	0.84408902
50	CAMK1G	0.77795070
51	MTOR	0.75852055
52	MET	0.72703886
53	EPHA3	0.72681155
54	ROCK1	0.70850547
55	MAPK7	0.70698925
56	NTRK1	0.69856952
57	CAMK1D	0.69796198
58	RPS6KA1	0.69458205
59	PRKG1	0.66189660
60	PDGFRB	0.65724410
61	EPHB2	0.62998771
62	DYRK2	0.62918603
63	PLK2	0.62800115
64	MAPK1	0.62123614
65	SIK1	0.61771244
66	MUSK	0.60590066
67	MST1R	0.60220427
68	WNK4	0.59521371
69	UHMK1	0.58932522
70	PRKCE	0.58307079
71	TRIB3	0.57470580
72	CDK3	0.57116229
73	CAMK4	0.57052614
74	MAP3K10	0.56909256
75	OBSCN	0.56859981
76	PAK4	0.56046824
77	TRPM7	0.52342364
78	ZAP70	0.51343970
79	MAPK13	0.50482798
80	SRPK1	0.49078514
81	MAPK8	0.46883043
82	PTK2B	0.46867154
83	MAPK4	0.46530357
84	TRIM28	0.42812052
85	BLK	0.42598024
86	NLK	0.41003901
87	FLT3	0.40786730
88	PRKACB	0.40533751
89	TYRO3	0.40437678
90	CHUK	0.39964581
91	ICK	0.38841494
92	BMX	0.38736269
93	AKT1	0.38280365
94	PAK2	0.38120989
95	MAPK12	0.37528939
96	GSK3A	0.37351500
97	PRKCZ	0.36681568
98	FGFR2	0.36422349
99	FER	0.35726278
100	NEK2	0.34950445

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	ECM-receptor interaction_Homo sapiens_hsa04512	3.29072406
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.75916543
3	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	2.53348487
4	Selenocompound metabolism_Homo sapiens_hsa00450	2.28077822
5	Dilated cardiomyopathy_Homo sapiens_hsa05414	2.21003858
6	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	2.16097086
7	Taste transduction_Homo sapiens_hsa04742	2.06427113
8	ABC transporters_Homo sapiens_hsa02010	2.03474529
9	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.97671627
10	Basal cell carcinoma_Homo sapiens_hsa05217	1.95549062
11	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.94921553
12	Circadian rhythm_Homo sapiens_hsa04710	1.89844638
13	Adherens junction_Homo sapiens_hsa04520	1.82370872
14	Focal adhesion_Homo sapiens_hsa04510	1.81575445
15	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.81228829
16	Protein digestion and absorption_Homo sapiens_hsa04974	1.77767778
17	Pertussis_Homo sapiens_hsa05133	1.72664643
18	Tight junction_Homo sapiens_hsa04530	1.64163455
19	Hippo signaling pathway_Homo sapiens_hsa04390	1.51807211
20	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.51655646
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.48262909
22	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.47242745
23	Complement and coagulation cascades_Homo sapiens_hsa04610	1.44032687
24	Glutamatergic synapse_Homo sapiens_hsa04724	1.42505570
25	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.39264716
26	Renin secretion_Homo sapiens_hsa04924	1.37848515
27	Notch signaling pathway_Homo sapiens_hsa04330	1.37764551
28	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.31315433
29	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.28910570
30	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.24889140
31	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.23614644
32	Axon guidance_Homo sapiens_hsa04360	1.23209861
33	Gap junction_Homo sapiens_hsa04540	1.17874049
34	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.11806552
35	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.11402558
36	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.03505604
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.03049898
38	Melanogenesis_Homo sapiens_hsa04916	1.01805827
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.01055703
40	Long-term depression_Homo sapiens_hsa04730	0.99341367
41	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.98819338
42	Bile secretion_Homo sapiens_hsa04976	0.97598826
43	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.97107793
44	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.95152525
45	Olfactory transduction_Homo sapiens_hsa04740	0.95105468
46	Phagosome_Homo sapiens_hsa04145	0.94838638
47	MAPK signaling pathway_Homo sapiens_hsa04010	0.93543946
48	Calcium signaling pathway_Homo sapiens_hsa04020	0.92592934
49	Nicotine addiction_Homo sapiens_hsa05033	0.92255658
50	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.90185616
51	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.89411090
52	Circadian entrainment_Homo sapiens_hsa04713	0.89160591
53	Serotonergic synapse_Homo sapiens_hsa04726	0.85758377
54	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.85424475
55	Mineral absorption_Homo sapiens_hsa04978	0.83820354
56	MicroRNAs in cancer_Homo sapiens_hsa05206	0.83794004
57	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.83291416
58	Wnt signaling pathway_Homo sapiens_hsa04310	0.82696465
59	Endocytosis_Homo sapiens_hsa04144	0.82075752
60	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.81676707
61	Proteoglycans in cancer_Homo sapiens_hsa05205	0.80966021
62	Type II diabetes mellitus_Homo sapiens_hsa04930	0.79455144
63	Rap1 signaling pathway_Homo sapiens_hsa04015	0.77574524
64	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.76048840
65	Fatty acid degradation_Homo sapiens_hsa00071	0.76033431
66	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.74634504
67	cAMP signaling pathway_Homo sapiens_hsa04024	0.74200480
68	Estrogen signaling pathway_Homo sapiens_hsa04915	0.72429071
69	Morphine addiction_Homo sapiens_hsa05032	0.70931591
70	Pathways in cancer_Homo sapiens_hsa05200	0.70262397
71	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.69289522
72	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.69160742
73	Phenylalanine metabolism_Homo sapiens_hsa00360	0.67800130
74	FoxO signaling pathway_Homo sapiens_hsa04068	0.65395257
75	Renal cell carcinoma_Homo sapiens_hsa05211	0.64875220
76	PPAR signaling pathway_Homo sapiens_hsa03320	0.63912338
77	Sulfur relay system_Homo sapiens_hsa04122	0.61835539
78	Viral myocarditis_Homo sapiens_hsa05416	0.60577589
79	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.60523558
80	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.60407690
81	Long-term potentiation_Homo sapiens_hsa04720	0.56674942
82	GABAergic synapse_Homo sapiens_hsa04727	0.52993769
83	Small cell lung cancer_Homo sapiens_hsa05222	0.52764849
84	Lysine degradation_Homo sapiens_hsa00310	0.51045259
85	Cholinergic synapse_Homo sapiens_hsa04725	0.49514796
86	Insulin resistance_Homo sapiens_hsa04931	0.49207897
87	Butanoate metabolism_Homo sapiens_hsa00650	0.48107413
88	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.46722298
89	Ras signaling pathway_Homo sapiens_hsa04014	0.46076288
90	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.45126449
91	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.44972596
92	Histidine metabolism_Homo sapiens_hsa00340	0.44691506
93	Tyrosine metabolism_Homo sapiens_hsa00350	0.42159594
94	Amoebiasis_Homo sapiens_hsa05146	0.42106151
95	Cocaine addiction_Homo sapiens_hsa05030	0.41533350
96	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.41420576
97	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.40722782
98	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.39989945
99	Salivary secretion_Homo sapiens_hsa04970	0.39959313
100	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.38954359

ADAMTS7P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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