ADAMTS8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. Reduced expression of this gene has been observed in multiple human cancers and this gene has been proposed as a potential tumor suppressor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)6.24268625
2cerebellar granule cell differentiation (GO:0021707)5.75232423
3type B pancreatic cell proliferation (GO:0044342)5.52323128
4respiratory tube development (GO:0030323)4.79857049
5dermatan sulfate biosynthetic process (GO:0030208)4.77937193
6bone trabecula formation (GO:0060346)4.59150472
7extracellular matrix assembly (GO:0085029)4.57176210
8negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.50769130
9dermatan sulfate metabolic process (GO:0030205)4.46911953
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.41451377
11establishment of apical/basal cell polarity (GO:0035089)4.28524662
12establishment of monopolar cell polarity (GO:0061162)4.27667158
13establishment or maintenance of monopolar cell polarity (GO:0061339)4.27667158
14glomerular filtration (GO:0003094)4.07626876
15glomerular basement membrane development (GO:0032836)4.06550809
16renal filtration (GO:0097205)4.01839350
17negative regulation of potassium ion transmembrane transport (GO:1901380)3.99874269
18mesenchymal cell differentiation involved in renal system development (GO:2001012)3.98578283
19mesenchymal cell differentiation involved in kidney development (GO:0072161)3.98578283
20cell proliferation involved in metanephros development (GO:0072203)3.88465654
21surfactant homeostasis (GO:0043129)3.75831568
22adhesion of symbiont to host cell (GO:0044650)3.72157387
23virion attachment to host cell (GO:0019062)3.72157387
24lymphangiogenesis (GO:0001946)3.68318859
25galactose catabolic process (GO:0019388)3.60419384
26lung vasculature development (GO:0060426)3.58343983
27cardiac myofibril assembly (GO:0055003)3.55580065
28non-canonical Wnt signaling pathway (GO:0035567)3.55396706
29cell differentiation involved in metanephros development (GO:0072202)3.54278783
30somatic stem cell division (GO:0048103)3.52528387
31metanephric mesenchyme development (GO:0072075)3.51652687
32regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.45488911
33sequestering of extracellular ligand from receptor (GO:0035581)3.45231055
34branching involved in salivary gland morphogenesis (GO:0060445)3.44400993
35regulation of glomerular filtration (GO:0003093)3.42165475
36middle ear morphogenesis (GO:0042474)3.39909627
37blood vessel maturation (GO:0001955)3.36491174
38plasma membrane repair (GO:0001778)3.29701375
39G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.28959274
40negative regulation of androgen receptor signaling pathway (GO:0060766)3.26680535
41chemical homeostasis within a tissue (GO:0048875)3.26325424
42regulation of response to osmotic stress (GO:0047484)3.22704402
43regulation of cell fate specification (GO:0042659)3.22018244
44endothelial cell morphogenesis (GO:0001886)3.21301603
45lens fiber cell development (GO:0070307)3.20616059
46regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.20204599
47tooth mineralization (GO:0034505)3.19166450
48peptide cross-linking (GO:0018149)3.17742581
49kidney mesenchyme development (GO:0072074)3.16540945
50adhesion of symbiont to host (GO:0044406)3.14867671
51regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.14319530
52cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.14030274
53paraxial mesoderm development (GO:0048339)3.13143318
54regulation of cardioblast differentiation (GO:0051890)3.11559845
55cell communication by electrical coupling (GO:0010644)3.11183181
56glutamate secretion (GO:0014047)3.10283065
57neuron projection extension involved in neuron projection guidance (GO:1902284)3.09794689
58axon extension involved in axon guidance (GO:0048846)3.09794689
59glomerular epithelial cell development (GO:0072310)3.09743013
60positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.08696622
61ventricular cardiac muscle cell action potential (GO:0086005)3.08225078
62negative regulation of catenin import into nucleus (GO:0035414)3.06923406
63polarized epithelial cell differentiation (GO:0030859)3.06405830
64cell communication involved in cardiac conduction (GO:0086065)3.04456341
65cell proliferation involved in kidney development (GO:0072111)3.02943521
66regulation of synaptic vesicle exocytosis (GO:2000300)3.02905945
67regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.02051238
68galactose metabolic process (GO:0006012)3.01582098
69regulation of sarcomere organization (GO:0060297)3.00557979
70embryonic foregut morphogenesis (GO:0048617)2.99531872
71mesenchymal-epithelial cell signaling (GO:0060638)2.98705843
72muscle cell cellular homeostasis (GO:0046716)2.97956921
73dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.96775370
74neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.96619777
75sarcomere organization (GO:0045214)2.96001935
76growth hormone secretion (GO:0030252)2.95227585
77lymph vessel development (GO:0001945)2.94390603
78cell migration involved in gastrulation (GO:0042074)2.93965377
79vasculature development (GO:0001944)2.93455181
80artery development (GO:0060840)2.92334975
81negative regulation of vascular permeability (GO:0043116)2.91044705
82regulation of hippo signaling (GO:0035330)2.90620249
83negative regulation of osteoblast proliferation (GO:0033689)2.89844367
84positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.89796130
85positive regulation of SMAD protein import into nucleus (GO:0060391)2.86146847
86regulation of respiratory system process (GO:0044065)2.84347418
87regulation of tight junction assembly (GO:2000810)2.83993354
88regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.83036108
89Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.82624043
90axon extension (GO:0048675)2.81547761
91cytoskeletal anchoring at plasma membrane (GO:0007016)2.79892664
92myofibril assembly (GO:0030239)2.79387937
93cardiac muscle cell proliferation (GO:0060038)2.79309495
94layer formation in cerebral cortex (GO:0021819)2.78190773
95vocalization behavior (GO:0071625)2.77998242
96cardiac muscle cell development (GO:0055013)2.76372937
97negative regulation of cell fate specification (GO:0009996)2.75729487
98regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.73972608
99cell migration involved in heart development (GO:0060973)2.73618315
100renal system process involved in regulation of blood volume (GO:0001977)2.73417218
101cell migration in hindbrain (GO:0021535)2.72364343
102camera-type eye morphogenesis (GO:0048593)2.72246939
103removal of superoxide radicals (GO:0019430)2.72214296
104cellular response to superoxide (GO:0071451)2.72214296
105cellular response to oxygen radical (GO:0071450)2.72214296
106actin-myosin filament sliding (GO:0033275)2.71650706
107muscle filament sliding (GO:0030049)2.71650706
108convergent extension (GO:0060026)2.69025291
109regulation of short-term neuronal synaptic plasticity (GO:0048172)2.68147095
110locomotory exploration behavior (GO:0035641)2.68000564
111keratan sulfate catabolic process (GO:0042340)2.67566064
112retina vasculature morphogenesis in camera-type eye (GO:0061299)2.67137344
113cardiac muscle cell action potential (GO:0086001)2.67080517
114dendritic spine morphogenesis (GO:0060997)2.66891756
115regulation of vasculogenesis (GO:2001212)2.66425475
116positive regulation of endothelial cell apoptotic process (GO:2000353)2.66040926
117regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.65729409
118cardiac cell development (GO:0055006)2.64817943
119cell migration involved in sprouting angiogenesis (GO:0002042)2.64577547
120regulation of endothelial cell differentiation (GO:0045601)2.64065875
121regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.63998135
122synaptic vesicle maturation (GO:0016188)2.63858715
123activation of protein kinase A activity (GO:0034199)2.63355729
124negative regulation of embryonic development (GO:0045992)2.62613373
125cardiac muscle cell action potential involved in contraction (GO:0086002)2.61783893
126regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.61549427
127short-term memory (GO:0007614)2.61508273
128pyrimidine nucleobase catabolic process (GO:0006208)2.61070728
129hippo signaling (GO:0035329)2.60865108
130renal system development (GO:0072001)2.60552718
131exploration behavior (GO:0035640)2.59280145
132regulation of synaptic vesicle transport (GO:1902803)2.59174152
133regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.57810159
134membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.57592408
135asymmetric protein localization (GO:0008105)2.57337987
136actomyosin structure organization (GO:0031032)2.56724684
137lung-associated mesenchyme development (GO:0060484)2.56228382
138chondrocyte proliferation (GO:0035988)2.56025794
139chondroitin sulfate catabolic process (GO:0030207)2.55878877
140bundle of His cell to Purkinje myocyte communication (GO:0086069)2.55721282
141protein heterotrimerization (GO:0070208)2.55226968
142metanephric nephron epithelium development (GO:0072243)2.55120691
143regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.55061974
144establishment of nucleus localization (GO:0040023)2.54750099
145positive regulation of axon extension (GO:0045773)2.54645386
146neuron projection regeneration (GO:0031102)2.54410802
147regulation of establishment of planar polarity (GO:0090175)2.54366897
148regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.53861058
149negative regulation of protein localization to cell surface (GO:2000009)2.52187599
150positive regulation of gastrulation (GO:2000543)2.51983126
151embryonic cranial skeleton morphogenesis (GO:0048701)2.51173539
152cardiac muscle contraction (GO:0060048)2.50289090
153diaphragm development (GO:0060539)2.49927329
154neuron projection extension (GO:1990138)2.49770555
155regulation of potassium ion transmembrane transporter activity (GO:1901016)2.49649671
156stress fiber assembly (GO:0043149)2.49640911
157planar cell polarity pathway involved in neural tube closure (GO:0090179)2.49247760
158G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.49039453
159innervation (GO:0060384)2.48122298
160negative regulation of cell fate commitment (GO:0010454)2.47716752
161pericardium development (GO:0060039)2.47685558
162central nervous system projection neuron axonogenesis (GO:0021952)2.47646270
163regulation of axon guidance (GO:1902667)2.46826476
164membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.46754295
165retinal ganglion cell axon guidance (GO:0031290)2.45173878
166regulation of synapse structural plasticity (GO:0051823)2.44936263
167endocardial cushion morphogenesis (GO:0003203)2.44422381
168regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.43967118
169negative regulation of systemic arterial blood pressure (GO:0003085)2.43667670
170negative regulation of axon guidance (GO:1902668)2.43280791
171basement membrane organization (GO:0071711)2.43276586
172extracellular fibril organization (GO:0043206)2.42286796
173outflow tract septum morphogenesis (GO:0003148)2.42285351
174axonal fasciculation (GO:0007413)2.41879112
175mammary gland development (GO:0030879)2.41757060
176striated muscle cell proliferation (GO:0014855)2.41360767
177desmosome organization (GO:0002934)2.40604221
178cochlea development (GO:0090102)2.39937276
179heart trabecula formation (GO:0060347)2.39127319
180lung epithelium development (GO:0060428)2.38445049
181membrane assembly (GO:0071709)2.38121908
182adherens junction assembly (GO:0034333)2.37980585
183regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.37431112

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.41813524
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.09865406
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.99332035
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.51351495
5* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.31512308
6* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.31512308
7EZH2_22144423_ChIP-Seq_EOC_Human2.30256374
8SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.24440404
9* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.21523895
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.13970960
11* EED_16625203_ChIP-ChIP_MESCs_Mouse2.12353619
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.11694403
13EP300_21415370_ChIP-Seq_HL-1_Mouse2.03894077
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.03173223
15* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.00003835
16ZFP281_18757296_ChIP-ChIP_E14_Mouse1.98476775
17JARID2_20064375_ChIP-Seq_MESCs_Mouse1.96783108
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.94057439
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.93799476
20EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.89726636
21* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.89170224
22ZNF217_24962896_ChIP-Seq_MCF-7_Human1.88599311
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87784193
24ERG_21242973_ChIP-ChIP_JURKAT_Human1.87338497
25WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.87205392
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.86994641
27DNAJC2_21179169_ChIP-ChIP_NT2_Human1.86094953
28* RNF2_27304074_Chip-Seq_ESCs_Mouse1.81798729
29* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.81711817
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.81388933
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.79212815
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.77671945
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75368117
34DROSHA_22980978_ChIP-Seq_HELA_Human1.74962830
35AHR_22903824_ChIP-Seq_MCF-7_Human1.72500111
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.70927649
37SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.65662447
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63813897
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.59726532
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.59507922
41* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.58006877
42RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.54684181
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54051479
44ZNF263_19887448_ChIP-Seq_K562_Human1.52129243
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51212027
46* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51166910
47RING1B_27294783_Chip-Seq_ESCs_Mouse1.50379679
48HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.47835246
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.47720045
50SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.47693127
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.47541262
52ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.47234879
53* CTCF_27219007_Chip-Seq_Bcells_Human1.47066391
54TP53_20018659_ChIP-ChIP_R1E_Mouse1.46400490
55RING1B_27294783_Chip-Seq_NPCs_Mouse1.41821788
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.41376382
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40356799
58NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.39063950
59KDM2B_26808549_Chip-Seq_K562_Human1.38890302
60RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38629130
61CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.35220731
62ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.34405716
63GBX2_23144817_ChIP-Seq_PC3_Human1.34306118
64TET1_21490601_ChIP-Seq_MESCs_Mouse1.33309153
65* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32535740
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30917183
67ISL1_27105846_Chip-Seq_CPCs_Mouse1.30544180
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29765104
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.29445971
70TCF3_18692474_ChIP-Seq_MEFs_Mouse1.29224857
71* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28174121
72* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27214168
73OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.26142510
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25329626
75* LXR_22292898_ChIP-Seq_THP-1_Human1.24904831
76EGR1_19032775_ChIP-ChIP_M12_Human1.21931099
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21424793
78CDX2_20551321_ChIP-Seq_CACO-2_Human1.21043467
79CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.17897363
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17309925
81WT1_19549856_ChIP-ChIP_CCG9911_Human1.17165630
82RARB_27405468_Chip-Seq_BRAIN_Mouse1.16577143
83* SMAD3_21741376_ChIP-Seq_HESCs_Human1.16340843
84KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.15215900
85KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.15215900
86KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.15215900
87TP53_18474530_ChIP-ChIP_U2OS_Human1.14573009
88NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13785295
89TBX20_22328084_ChIP-Seq_HEART_Mouse1.11830757
90TBX20_22080862_ChIP-Seq_HEART_Mouse1.11830757
91STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.11208226
92TCF4_18268006_ChIP-ChIP_LS174T_Human1.09650033
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08680818
94NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08449515
95REST_21632747_ChIP-Seq_MESCs_Mouse1.08378893
96AR_21572438_ChIP-Seq_LNCaP_Human1.08153014
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07891854
98TP63_17297297_ChIP-ChIP_HaCaT_Human1.07364186
99TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07260250
100* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.06612412
101SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06065913
102NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05819374
103RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05620536
104CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04824427
105MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04821276
106NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.04664701
107TP53_16413492_ChIP-PET_HCT116_Human1.03010706
108NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.01655789
109* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01511543
110* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01427486
111TCF3_18692474_ChIP-Seq_MESCs_Mouse1.00663709
112ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00480065
113YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00335353
114* SMAD4_21741376_ChIP-Seq_HESCs_Human0.98499653
115PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98119327
116TP53_23651856_ChIP-Seq_MEFs_Mouse0.97660678
117CJUN_26792858_Chip-Seq_BT549_Human0.97399747
118SMAD_19615063_ChIP-ChIP_OVARY_Human0.97376714
119STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97260397
120PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96899744
121RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96810455
122CLOCK_20551151_ChIP-Seq_293T_Human0.96508095
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95898346
124* SOX2_21211035_ChIP-Seq_LN229_Gbm0.95799496
125* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95796211
126SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95728395
127GATA2_21666600_ChIP-Seq_HMVEC_Human0.95696083
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94677834
129* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.94542800
130TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.93962272
131KDM2B_26808549_Chip-Seq_DND41_Human0.93322874
132RACK7_27058665_Chip-Seq_MCF-7_Human0.92807521
133CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92565000
134SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87864480
135TBX3_20139965_ChIP-Seq_MESCs_Mouse0.86982983
136TBX3_20139965_ChIP-Seq_ESCs_Mouse0.86190841
137SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.80268010
138SA1_27219007_Chip-Seq_ERYTHROID_Human0.80203697
139KLF4_19829295_ChIP-Seq_ESCs_Human0.80202894
140* SA1_22415368_ChIP-Seq_MEFs_Mouse0.78876248

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology4.23624627
2MP0004084_abnormal_cardiac_muscle3.55442239
3MP0005623_abnormal_meninges_morphology3.21084883
4MP0004272_abnormal_basement_membrane3.11523276
5MP0000751_myopathy3.00805331
6MP0003941_abnormal_skin_development2.85408317
7MP0010368_abnormal_lymphatic_system2.67911154
8MP0002837_dystrophic_cardiac_calcinosis2.63227295
9MP0009780_abnormal_chondrocyte_physiolo2.43571121
10MP0006054_spinal_hemorrhage2.39665723
11MP0004036_abnormal_muscle_relaxation2.37503954
12MP0004215_abnormal_myocardial_fiber2.31691021
13MP0004859_abnormal_synaptic_plasticity2.25846221
14MP0005330_cardiomyopathy2.24370750
15MP0010386_abnormal_urinary_bladder2.17151367
16MP0001299_abnormal_eye_distance/2.16560864
17MP0000049_abnormal_middle_ear2.12413420
18MP0001879_abnormal_lymphatic_vessel2.10659171
19MP0002972_abnormal_cardiac_muscle2.10622376
20MP0005508_abnormal_skeleton_morphology2.08618659
21MP0001958_emphysema2.03685752
22MP0003122_maternal_imprinting1.93401085
23MP0004883_abnormal_blood_vessel1.92222858
24MP0003137_abnormal_impulse_conducting1.85710690
25MP0005620_abnormal_muscle_contractility1.84142113
26MP0003950_abnormal_plasma_membrane1.82029602
27MP0003705_abnormal_hypodermis_morpholog1.81792883
28MP0006138_congestive_heart_failure1.81378408
29MP0003828_pulmonary_edema1.81068634
30MP0004087_abnormal_muscle_fiber1.74528816
31MP0004484_altered_response_of1.71595347
32MP0004085_abnormal_heartbeat1.68376108
33MP0003566_abnormal_cell_adhesion1.67620257
34MP0000750_abnormal_muscle_regeneration1.64008121
35MP0003938_abnormal_ear_development1.63339510
36MP0001986_abnormal_taste_sensitivity1.62979599
37MP0000428_abnormal_craniofacial_morphol1.62884772
38MP0005167_abnormal_blood-brain_barrier1.62396064
39MP0008260_abnormal_autophagy1.60989910
40MP0005385_cardiovascular_system_phenoty1.60810514
41MP0001544_abnormal_cardiovascular_syste1.60810514
42MP0009250_abnormal_appendicular_skeleto1.60071922
43MP0004858_abnormal_nervous_system1.57612925
44MP0003091_abnormal_cell_migration1.54995141
45MP0010630_abnormal_cardiac_muscle1.53785620
46MP0004270_analgesia1.48538119
47MP0004145_abnormal_muscle_electrophysio1.47786843
48MP0005257_abnormal_intraocular_pressure1.46616871
49MP0000534_abnormal_ureter_morphology1.46513971
50MP0002127_abnormal_cardiovascular_syste1.46335607
51MP0008775_abnormal_heart_ventricle1.44773095
52MP0000537_abnormal_urethra_morphology1.42321124
53MP0000749_muscle_degeneration1.40150962
54MP0004233_abnormal_muscle_weight1.36142385
55MP0003880_abnormal_central_pattern1.34210041
56MP0002332_abnormal_exercise_endurance1.31380092
57MP0003635_abnormal_synaptic_transmissio1.30175926
58MP0003283_abnormal_digestive_organ1.30096942
59MP0008004_abnormal_stomach_pH1.26268249
60MP0003279_aneurysm1.25616548
61MP0004885_abnormal_endolymph1.25511205
62MP0005023_abnormal_wound_healing1.24092688
63MP0002295_abnormal_pulmonary_circulatio1.22684744
64MP0005076_abnormal_cell_differentiation1.20430102
65MP0000778_abnormal_nervous_system1.20254461
66MP0000569_abnormal_digit_pigmentation1.20062495
67MP0002249_abnormal_larynx_morphology1.19364311
68MP0002653_abnormal_ependyma_morphology1.19152544
69MP0009384_cardiac_valve_regurgitation1.19093276
70MP0009379_abnormal_foot_pigmentation1.18316355
71MP0002736_abnormal_nociception_after1.16840104
72MP0009745_abnormal_behavioral_response1.15933663
73MP0010030_abnormal_orbit_morphology1.15762809
74MP0003115_abnormal_respiratory_system1.15660262
75MP0005275_abnormal_skin_tensile1.15305485
76MP0002733_abnormal_thermal_nociception1.14432353
77MP0003123_paternal_imprinting1.12801307
78MP0003942_abnormal_urinary_system1.11996483
79MP0001968_abnormal_touch/_nociception1.11208684
80MP0005595_abnormal_vascular_smooth1.11163100
81MP0002272_abnormal_nervous_system1.08892788
82MP0000762_abnormal_tongue_morphology1.08506522
83MP0002925_abnormal_cardiovascular_devel1.06511007
84MP0001849_ear_inflammation1.05481713
85MP0002106_abnormal_muscle_physiology1.05292477
86MP0004133_heterotaxia1.02765603
87MP0003937_abnormal_limbs/digits/tail_de1.02753841
88MP0002734_abnormal_mechanical_nocicepti1.01778734
89MP0000462_abnormal_digestive_system0.99855240
90MP0003119_abnormal_digestive_system0.98809879
91MP0002063_abnormal_learning/memory/cond0.97309339
92MP0002116_abnormal_craniofacial_bone0.97174977
93MP0000266_abnormal_heart_morphology0.96894974
94MP0000163_abnormal_cartilage_morphology0.96753097
95MP0003385_abnormal_body_wall0.96733088
96MP0002933_joint_inflammation0.96108886
97MP0000759_abnormal_skeletal_muscle0.95874567
98MP0003329_amyloid_beta_deposits0.94955549
99MP0003633_abnormal_nervous_system0.94213328
100MP0005390_skeleton_phenotype0.94143611
101MP0000733_abnormal_muscle_development0.93447701
102MP0008438_abnormal_cutaneous_collagen0.93394429
103MP0001970_abnormal_pain_threshold0.93244654
104MP0010352_gastrointestinal_tract_polyps0.93077927
105MP0002064_seizures0.92803722
106MP0002133_abnormal_respiratory_system0.92465042
107MP0005388_respiratory_system_phenotype0.92465042
108MP0005369_muscle_phenotype0.91893141
109MP0000767_abnormal_smooth_muscle0.91240889
110MP0003879_abnormal_hair_cell0.91002838
111MP0001486_abnormal_startle_reflex0.90372912
112MP0000955_abnormal_spinal_cord0.90130105
113MP0002108_abnormal_muscle_morphology0.88397826
114MP0005164_abnormal_response_to0.88366944
115MP0002735_abnormal_chemical_nociception0.87882522
116MP0001501_abnormal_sleep_pattern0.86795838
117MP0002115_abnormal_skeleton_extremities0.86528990
118MP0002234_abnormal_pharynx_morphology0.86522534
119MP0000747_muscle_weakness0.86335223
120MP0002572_abnormal_emotion/affect_behav0.86277384
121MP0001542_abnormal_bone_strength0.85442044
122MP0000613_abnormal_salivary_gland0.84847409
123MP0004782_abnormal_surfactant_physiolog0.83911560
124MP0000681_abnormal_thyroid_gland0.83655155
125MP0002269_muscular_atrophy0.83573731
126MP0002896_abnormal_bone_mineralization0.83301144
127MP0002184_abnormal_innervation0.82219776
128MP0008961_abnormal_basal_metabolism0.82069981
129MP0002060_abnormal_skin_morphology0.81343784
130MP0000467_abnormal_esophagus_morphology0.80848301
131MP0002254_reproductive_system_inflammat0.79423518
132MP0001177_atelectasis0.79025986
133MP0001502_abnormal_circadian_rhythm0.78662965
134MP0000432_abnormal_head_morphology0.78213628
135MP0005187_abnormal_penis_morphology0.77863431
136MP0003634_abnormal_glial_cell0.77638967
137MP0002282_abnormal_trachea_morphology0.76573615
138MP0002697_abnormal_eye_size0.76308232
139MP0003567_abnormal_fetal_cardiomyocyte0.75637623
140MP0001175_abnormal_lung_morphology0.75386463
141MP0000566_synostosis0.75236717
142MP0001905_abnormal_dopamine_level0.75121955
143MP0005165_increased_susceptibility_to0.74824026
144MP0001440_abnormal_grooming_behavior0.74476091
145MP0001243_abnormal_dermal_layer0.74354229
146MP0003935_abnormal_craniofacial_develop0.74349907
147MP0001346_abnormal_lacrimal_gland0.74266083
148MP0002128_abnormal_blood_circulation0.72370252
149MP0002233_abnormal_nose_morphology0.71195469
150MP0008569_lethality_at_weaning0.70123030
151MP0008995_early_reproductive_senescence0.69567632
152MP0000538_abnormal_urinary_bladder0.68599870
153MP0001529_abnormal_vocalization0.68169293
154MP0001270_distended_abdomen0.67148550
155MP0000013_abnormal_adipose_tissue0.67110327

Predicted human phenotypes

RankGene SetZ-score
1Fibular aplasia (HP:0002990)4.96649495
2Sudden death (HP:0001699)4.42083294
3Synostosis involving the elbow (HP:0003938)4.40643352
4Humeroradial synostosis (HP:0003041)4.40643352
5Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.01810043
6Broad metatarsal (HP:0001783)3.93409684
7Type 1 muscle fiber predominance (HP:0003803)3.88121028
8Cervical subluxation (HP:0003308)3.67996531
9Ankle contracture (HP:0006466)3.61652660
10Split foot (HP:0001839)3.60421877
11Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.53663282
12Shallow orbits (HP:0000586)3.49748093
13Myokymia (HP:0002411)3.39842876
14Abnormality of the pubic bones (HP:0003172)3.31635539
15Hyporeflexia of lower limbs (HP:0002600)3.27391772
16Mildly elevated creatine phosphokinase (HP:0008180)3.23456884
17Coronal craniosynostosis (HP:0004440)3.18771759
18Arterial tortuosity (HP:0005116)3.16653820
19Soft skin (HP:0000977)3.14954986
20Aortic aneurysm (HP:0004942)3.11182647
21Right ventricular cardiomyopathy (HP:0011663)3.07592436
22Ventricular tachycardia (HP:0004756)3.06979086
23Abnormality of the calf musculature (HP:0001430)3.06692996
24Papilledema (HP:0001085)2.97748266
25Muscle fiber splitting (HP:0003555)2.91140697
26Increased connective tissue (HP:0009025)2.89925527
27Abnormal finger flexion creases (HP:0006143)2.82352548
28Cerebral aneurysm (HP:0004944)2.74596560
29Hydroureter (HP:0000072)2.72851538
30Tarsal synostosis (HP:0008368)2.72499859
31Neoplasm of the heart (HP:0100544)2.71811726
32Mesomelia (HP:0003027)2.57474666
33Follicular hyperkeratosis (HP:0007502)2.57184997
34Achilles tendon contracture (HP:0001771)2.55946223
35Synostosis involving bones of the feet (HP:0009140)2.53413341
36Synostosis involving bones of the lower limbs (HP:0009138)2.53413341
37Primary atrial arrhythmia (HP:0001692)2.53150021
38Visual hallucinations (HP:0002367)2.53054015
39Aortic dissection (HP:0002647)2.52662541
40Myotonia (HP:0002486)2.52192313
41Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.51928063
42Short 4th metacarpal (HP:0010044)2.51928063
43Turricephaly (HP:0000262)2.51329325
44Increased variability in muscle fiber diameter (HP:0003557)2.50806888
45Supraventricular arrhythmia (HP:0005115)2.50351884
46Oligodactyly (hands) (HP:0001180)2.49981807
47Atrial fibrillation (HP:0005110)2.48564703
48Interstitial pulmonary disease (HP:0006530)2.46701720
49Aplasia involving bones of the upper limbs (HP:0009823)2.46435292
50Aplasia of the phalanges of the hand (HP:0009802)2.46435292
51Aplasia involving bones of the extremities (HP:0009825)2.46435292
52Breech presentation (HP:0001623)2.40522779
53Syncope (HP:0001279)2.40420119
54Distal lower limb muscle weakness (HP:0009053)2.39460561
55Supraventricular tachycardia (HP:0004755)2.39307324
56Joint laxity (HP:0001388)2.37251133
57Bronchomalacia (HP:0002780)2.36997544
58Slender build (HP:0001533)2.36140725
59Hypoplastic pelvis (HP:0008839)2.31752539
60Wrist flexion contracture (HP:0001239)2.30929082
61Hepatoblastoma (HP:0002884)2.30509148
62Bell-shaped thorax (HP:0001591)2.29664652
63Annular pancreas (HP:0001734)2.28348535
64Exercise-induced myalgia (HP:0003738)2.28144105
65Symphalangism affecting the phalanges of the hand (HP:0009773)2.26315541
66Exercise-induced muscle cramps (HP:0003710)2.24390564
67Adactyly (HP:0009776)2.22916204
68EMG: myopathic abnormalities (HP:0003458)2.22179115
69Choanal stenosis (HP:0000452)2.20906615
70Ventricular arrhythmia (HP:0004308)2.20785102
71Mesangial abnormality (HP:0001966)2.19712552
72Abnormality of dentin (HP:0010299)2.18548746
73Difficulty running (HP:0009046)2.17230003
74Round ear (HP:0100830)2.15985230
75Vertebral compression fractures (HP:0002953)2.15664924
76Lower limb amyotrophy (HP:0007210)2.15327736
77Abnormality of skeletal muscle fiber size (HP:0012084)2.14211791
78Abnormality of the Achilles tendon (HP:0005109)2.13840300
79Ependymoma (HP:0002888)2.13354209
80Bowed forearm bones (HP:0003956)2.12528615
81Bowing of the arm (HP:0006488)2.12528615
82Muscle fiber inclusion bodies (HP:0100299)2.12380663
83Ventricular fibrillation (HP:0001663)2.12175431
84Pulmonary artery stenosis (HP:0004415)2.11941330
85Subaortic stenosis (HP:0001682)2.11909620
86Abnormality of the left ventricular outflow tract (HP:0011103)2.11909620
87Mitral regurgitation (HP:0001653)2.10653732
88Emphysema (HP:0002097)2.08582544
89Facial diplegia (HP:0001349)2.07816260
90EMG: neuropathic changes (HP:0003445)2.06616635
91Lymphangioma (HP:0100764)2.05825487
92Hypoplastic left heart (HP:0004383)2.04711611
93Abnormal delivery (HP:0001787)2.03782735
94Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.03499245
95Hip contracture (HP:0003273)2.02622325
96Hyperextensible skin (HP:0000974)2.02126405
97Premature skin wrinkling (HP:0100678)2.01227613
98Neonatal short-limb short stature (HP:0008921)1.99853878
99Difficulty climbing stairs (HP:0003551)1.99541411
100Wormian bones (HP:0002645)1.98778070
101Radial bowing (HP:0002986)1.98586526
102Blue sclerae (HP:0000592)1.98409403
103Abnormality of the humeroradial joint (HP:0100744)1.97940912
104Urethral obstruction (HP:0000796)1.97765124
105Patent foramen ovale (HP:0001655)1.97165707
106Fragile skin (HP:0001030)1.96825725
107Hemangiomatosis (HP:0007461)1.96713655
108Focal seizures (HP:0007359)1.95585828
109Abnormality of the 4th metacarpal (HP:0010012)1.95313873
110Cutaneous syndactyly (HP:0012725)1.95099985
111Aortic valve stenosis (HP:0001650)1.94989125
112Action tremor (HP:0002345)1.94902107
113Bowel diverticulosis (HP:0005222)1.94670367
114Scapular winging (HP:0003691)1.94122949
115Lipoatrophy (HP:0100578)1.93756893
116Abnormality of cochlea (HP:0000375)1.93688648
117Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.93169383
118Abnormality of the middle phalanges of the toes (HP:0010183)1.92642762
119Midline defect of the nose (HP:0004122)1.92208868
120Focal motor seizures (HP:0011153)1.91792640
121Spinal rigidity (HP:0003306)1.90378160
122Aneurysm (HP:0002617)1.89541343
123Abnormality of the humerus (HP:0003063)1.88450927
124Asymmetric septal hypertrophy (HP:0001670)1.88222885
125Premature rupture of membranes (HP:0001788)1.87881838
126Visceral angiomatosis (HP:0100761)1.86820292
127Torticollis (HP:0000473)1.86800323
128Shawl scrotum (HP:0000049)1.86041376
129Athetosis (HP:0002305)1.85852511
130Partial duplication of thumb phalanx (HP:0009944)1.85789491
131Long toe (HP:0010511)1.85747188
132Hypoplasia of the odontoid process (HP:0003311)1.84616767
133Aplasia/Hypoplasia of the fibula (HP:0006492)1.84183950
134Atonic seizures (HP:0010819)1.83531285
135Prolonged QT interval (HP:0001657)1.83035306
136Skin nodule (HP:0200036)1.82964600
137Atelectasis (HP:0100750)1.82588142
138Camptodactyly of toe (HP:0001836)1.79291599
139Duplication of thumb phalanx (HP:0009942)1.79245117
140Bundle branch block (HP:0011710)1.78851710
141Overgrowth (HP:0001548)1.77900111
142Abnormality of the upper arm (HP:0001454)1.77845504
143Septo-optic dysplasia (HP:0100842)1.77778269
144Rectal prolapse (HP:0002035)1.77746771
145Atrophic scars (HP:0001075)1.76796002
146Distal arthrogryposis (HP:0005684)1.74640008
147Subacute progressive viral hepatitis (HP:0006572)1.73043252
148Bladder diverticulum (HP:0000015)1.72855303
149Limited hip movement (HP:0008800)1.70918098
150Distal lower limb amyotrophy (HP:0008944)1.68847817
151Neck muscle weakness (HP:0000467)1.68566302
152Protrusio acetabuli (HP:0003179)1.66162975
153Hemiplegia (HP:0002301)1.65209616
154Absence seizures (HP:0002121)1.65041119
155Cutaneous finger syndactyly (HP:0010554)1.64564072
156Abnormality of the labia minora (HP:0012880)1.64535489
157Limb-girdle muscle weakness (HP:0003325)1.63745145
158Rapidly progressive (HP:0003678)1.63340657
159Limb-girdle muscle atrophy (HP:0003797)1.63266366
160Hypoventilation (HP:0002791)1.62971644
161Abnormality of the tricuspid valve (HP:0001702)1.61207469
162Mitral valve prolapse (HP:0001634)1.60173696
163Chin dimple (HP:0010751)1.60001782
164Nemaline bodies (HP:0003798)1.59587931
165Dilatation of the ascending aorta (HP:0005111)1.58353279
166Steppage gait (HP:0003376)1.58002214
167Abnormality of the foot musculature (HP:0001436)1.57289103
168Broad ribs (HP:0000885)1.57030935
169Skull defect (HP:0001362)1.56108526
170Renal duplication (HP:0000075)1.55540442
171Abnormal atrioventricular conduction (HP:0005150)1.52825642
172Truncus arteriosus (HP:0001660)1.51986032
173Vascular tortuosity (HP:0004948)1.51769299

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB24.00915759
2MYLK3.39856810
3ADRBK23.28791973
4MARK13.18069339
5TIE12.91842335
6MAP3K92.69189391
7NTRK12.26559633
8TTN2.18065607
9KSR12.15478190
10PHKG22.13260317
11PHKG12.13260317
12LATS21.93551662
13TGFBR21.90995892
14LMTK21.90263094
15DMPK1.81858227
16RPS6KA21.81747351
17NTRK31.79507275
18ADRBK11.72044050
19BCR1.66342217
20TAOK11.64530098
21AKT31.61379554
22PKN11.59770655
23PRPF4B1.46490672
24MINK11.45932905
25FER1.43859312
26DAPK21.42287240
27PAK61.41650233
28GRK61.40354221
29NTRK21.39593747
30CDC42BPA1.38636715
31LIMK11.37942753
32GRK51.35013614
33PAK21.34442773
34PAK31.34363893
35NEK11.34068208
36CASK1.34058435
37GRK71.33064103
38KSR21.32909333
39SIK31.30313377
40PDGFRA1.27862607
41TRIB31.27377195
42OBSCN1.26832206
43EPHA21.24326378
44ARAF1.21173807
45MAP3K31.18487956
46PRKD21.16408641
47DYRK21.10262674
48PTK2B1.06088962
49DDR21.05714570
50CAMK2B1.05217235
51MAP3K101.01785315
52ABL21.01036453
53PDK41.00861120
54PDK31.00861120
55MAP3K21.00102573
56MAPK150.96340021
57CAMKK10.96045988
58BRSK10.95000220
59ICK0.93589244
60RPS6KC10.93513623
61RPS6KL10.93513623
62TNIK0.92294339
63RPS6KA60.92210563
64MAP2K30.87034686
65PTK20.86843521
66CDK80.86597337
67FGFR20.85678336
68ALK0.85039109
69PKN20.85028525
70ROCK10.83219721
71TESK10.82947442
72CAMK10.82267684
73SIK10.81050016
74UHMK10.80817466
75PINK10.80103198
76MELK0.79836231
77DAPK30.78983607
78ILK0.78676756
79PDK20.78217237
80PDGFRB0.78045214
81RIPK10.77669526
82TYRO30.77576754
83EPHB10.77177341
84PRKG20.76785307
85STK380.76474243
86ERBB20.75102038
87TAOK20.74181656
88PRKCG0.71517068
89FLT30.70889141
90BMX0.67784842
91MAP3K40.67265154
92MAP3K110.66591188
93FGFR10.63800473
94FRK0.63340146
95MAP2K60.63100082
96MAP2K40.63052879
97SGK4940.62899815
98SGK2230.62899815
99KIT0.62486260
100TGFBR10.62283309
101STK30.62058042
102PAK40.62016699
103MAPK70.61520792
104MAPK120.61439917
105LATS10.60979152
106PAK10.60618447
107SMG10.60153224
108PRKCZ0.58046712
109GSK3A0.57824552
110BRAF0.57305697
111PTK60.56981843
112EEF2K0.56610857
113TTK0.56479229
114PDPK10.56035630
115PRKG10.52910585
116PRKCE0.52076451
117MTOR0.51257328
118NUAK10.51238194
119MAP3K70.51211238
120CDK50.51180415
121MAP2K10.51053400
122CDK190.50928203
123ROCK20.50758712
124CAMK1G0.50262249
125PRKD30.50255993
126PIK3CA0.49640659
127EPHA30.49378345
128CAMK2D0.47781266
129MET0.46727393
130CAMK2A0.46067244
131RPS6KA30.44889320
132CAMK2G0.43261725
133PRKD10.42943009
134EPHA40.42657658
135ERBB30.42525761
136RPS6KA10.42422933
137CDK180.41942328
138DAPK10.41184737
139EGFR0.40110296
140MAPK40.39308395
141GRK10.38435074
142FGFR40.38352054
143SRC0.37406876
144ERBB40.35573302
145HIPK20.34405151
146MATK0.34205668
147PRKCI0.34010951
148MARK20.33753493
149MAPKAPK30.33617745
150CDK140.33571308
151PLK20.33218552
152PRKCH0.33208825
153RET0.32185089

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007502.89937422
2Dilated cardiomyopathy_Homo sapiens_hsa054142.58283304
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.37256008
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.24992170
5Axon guidance_Homo sapiens_hsa043601.93666063
6Focal adhesion_Homo sapiens_hsa045101.87110619
7Adherens junction_Homo sapiens_hsa045201.85642157
8Tight junction_Homo sapiens_hsa045301.85575157
9ECM-receptor interaction_Homo sapiens_hsa045121.84139976
10Hippo signaling pathway_Homo sapiens_hsa043901.83150260
11Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.81094799
12Cardiac muscle contraction_Homo sapiens_hsa042601.77764043
13Basal cell carcinoma_Homo sapiens_hsa052171.66520087
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55444195
15Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.54770390
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.54419208
17Circadian entrainment_Homo sapiens_hsa047131.50670274
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50595880
19Renin secretion_Homo sapiens_hsa049241.49932287
20Gastric acid secretion_Homo sapiens_hsa049711.45614591
21GABAergic synapse_Homo sapiens_hsa047271.43814964
22Gap junction_Homo sapiens_hsa045401.43512546
23Oxytocin signaling pathway_Homo sapiens_hsa049211.43148600
24Viral myocarditis_Homo sapiens_hsa054161.39548750
25Melanogenesis_Homo sapiens_hsa049161.38991369
26Cocaine addiction_Homo sapiens_hsa050301.38467140
27Galactose metabolism_Homo sapiens_hsa000521.37886499
28Estrogen signaling pathway_Homo sapiens_hsa049151.37241341
29cGMP-PKG signaling pathway_Homo sapiens_hsa040221.35052595
30Synaptic vesicle cycle_Homo sapiens_hsa047211.34269043
31Dorso-ventral axis formation_Homo sapiens_hsa043201.33701198
32Proteoglycans in cancer_Homo sapiens_hsa052051.31548182
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.30581948
34Thyroid hormone synthesis_Homo sapiens_hsa049181.28587800
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.28532379
36Salivary secretion_Homo sapiens_hsa049701.28436346
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.28000283
38Nicotine addiction_Homo sapiens_hsa050331.25046202
39Taste transduction_Homo sapiens_hsa047421.24543652
40Morphine addiction_Homo sapiens_hsa050321.24056443
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22525596
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21682256
43GnRH signaling pathway_Homo sapiens_hsa049121.18419256
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.17005532
45Hedgehog signaling pathway_Homo sapiens_hsa043401.12731783
46Endometrial cancer_Homo sapiens_hsa052131.11735321
47Wnt signaling pathway_Homo sapiens_hsa043101.10240381
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10000471
49Rap1 signaling pathway_Homo sapiens_hsa040151.09972344
50Regulation of actin cytoskeleton_Homo sapiens_hsa048101.07891427
51Amoebiasis_Homo sapiens_hsa051461.07864592
52cAMP signaling pathway_Homo sapiens_hsa040241.07805427
53ErbB signaling pathway_Homo sapiens_hsa040121.05514942
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05075235
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05070004
56Notch signaling pathway_Homo sapiens_hsa043301.04841674
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04766411
58Long-term potentiation_Homo sapiens_hsa047201.04740888
59Bladder cancer_Homo sapiens_hsa052191.04554110
60Glioma_Homo sapiens_hsa052141.04380459
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02987847
62Leukocyte transendothelial migration_Homo sapiens_hsa046701.01940939
63Protein digestion and absorption_Homo sapiens_hsa049741.01563573
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99796278
65Insulin secretion_Homo sapiens_hsa049110.97966979
66Olfactory transduction_Homo sapiens_hsa047400.97059935
67Dopaminergic synapse_Homo sapiens_hsa047280.96017194
68Colorectal cancer_Homo sapiens_hsa052100.95085463
69Selenocompound metabolism_Homo sapiens_hsa004500.94633364
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93652918
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93652303
72Calcium signaling pathway_Homo sapiens_hsa040200.92582501
73Cholinergic synapse_Homo sapiens_hsa047250.92509270
74MicroRNAs in cancer_Homo sapiens_hsa052060.91961519
75Glutamatergic synapse_Homo sapiens_hsa047240.91419703
76Renal cell carcinoma_Homo sapiens_hsa052110.90262554
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.89231143
78mTOR signaling pathway_Homo sapiens_hsa041500.86666604
79Prion diseases_Homo sapiens_hsa050200.86583228
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.85138425
81VEGF signaling pathway_Homo sapiens_hsa043700.83651222
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.82756695
83Oocyte meiosis_Homo sapiens_hsa041140.82355057
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.81299539
85Amphetamine addiction_Homo sapiens_hsa050310.80719439
86Pathways in cancer_Homo sapiens_hsa052000.76232552
87Vibrio cholerae infection_Homo sapiens_hsa051100.74731483
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73659366
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72453669
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71522443
91TGF-beta signaling pathway_Homo sapiens_hsa043500.71036971
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69643777
93Small cell lung cancer_Homo sapiens_hsa052220.67428861
94MAPK signaling pathway_Homo sapiens_hsa040100.67407681
95Melanoma_Homo sapiens_hsa052180.66716852
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66638699
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65460778
98Long-term depression_Homo sapiens_hsa047300.64538583
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.64043494
100Platelet activation_Homo sapiens_hsa046110.64014927
101HIF-1 signaling pathway_Homo sapiens_hsa040660.62396343
102Insulin signaling pathway_Homo sapiens_hsa049100.62331979
103Serotonergic synapse_Homo sapiens_hsa047260.61767728
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60182209
105Complement and coagulation cascades_Homo sapiens_hsa046100.60119877
106Choline metabolism in cancer_Homo sapiens_hsa052310.59725319
107Glucagon signaling pathway_Homo sapiens_hsa049220.59682267
108Ras signaling pathway_Homo sapiens_hsa040140.59309679
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58715215
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57826455
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57259447
112Folate biosynthesis_Homo sapiens_hsa007900.56397076
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56094562
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54484333
115African trypanosomiasis_Homo sapiens_hsa051430.53932790
116Bile secretion_Homo sapiens_hsa049760.53380670
117Ribosome_Homo sapiens_hsa030100.51901742
118Type II diabetes mellitus_Homo sapiens_hsa049300.51789225
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.51464518
120Pancreatic secretion_Homo sapiens_hsa049720.50566136
121Histidine metabolism_Homo sapiens_hsa003400.50291162
122Butanoate metabolism_Homo sapiens_hsa006500.50210238
123Endocytosis_Homo sapiens_hsa041440.49512808
124Mineral absorption_Homo sapiens_hsa049780.49296457
125Prostate cancer_Homo sapiens_hsa052150.43018450
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.41697174

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