ADAMTS9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. Members of the ADAMTS family have been implicated in the cleavage of proteoglycans, the control of organ shape during development, and the inhibition of angiogenesis. This gene is localized to chromosome 3p14.3-p14.2, an area known to be lost in hereditary renal tumors. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)6.76271586
2daunorubicin metabolic process (GO:0044597)6.76271586
3polyketide metabolic process (GO:0030638)6.76271586
4cell proliferation involved in metanephros development (GO:0072203)4.48004435
5polarized epithelial cell differentiation (GO:0030859)4.42641761
6bone trabecula formation (GO:0060346)4.30827803
7aminoglycoside antibiotic metabolic process (GO:0030647)4.24071370
8endothelium development (GO:0003158)4.20827289
9cardiac myofibril assembly (GO:0055003)4.14899634
10notochord development (GO:0030903)4.08669881
11cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.01611376
12paraxial mesoderm development (GO:0048339)3.93465351
13retina vasculature morphogenesis in camera-type eye (GO:0061299)3.87797884
14myofibril assembly (GO:0030239)3.74687803
15basement membrane organization (GO:0071711)3.72141129
16cell proliferation involved in kidney development (GO:0072111)3.69346686
17regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.63067054
18establishment of apical/basal cell polarity (GO:0035089)3.59885469
19cell communication by electrical coupling (GO:0010644)3.59285132
20mesenchyme morphogenesis (GO:0072132)3.56404387
21sequestering of extracellular ligand from receptor (GO:0035581)3.54820282
22regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.53320891
23interleukin-6-mediated signaling pathway (GO:0070102)3.52156537
24negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.51294072
25regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.46706753
26regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.45702298
27coronary vasculature morphogenesis (GO:0060977)3.45431513
28mesenchymal cell proliferation (GO:0010463)3.43787602
29regulation of cardioblast differentiation (GO:0051890)3.38248974
30branching involved in salivary gland morphogenesis (GO:0060445)3.37049070
31negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.36978049
32vascular endothelial growth factor signaling pathway (GO:0038084)3.36015039
33positive regulation of astrocyte differentiation (GO:0048711)3.34549088
34positive regulation of p38MAPK cascade (GO:1900745)3.34341190
35glomerular filtration (GO:0003094)3.34221269
36ovulation from ovarian follicle (GO:0001542)3.34042030
37pericardium development (GO:0060039)3.28546216
38negative regulation of epidermis development (GO:0045683)3.27372253
39somite rostral/caudal axis specification (GO:0032525)3.26465536
40hippo signaling (GO:0035329)3.23369195
41negative regulation of hormone biosynthetic process (GO:0032353)3.23194817
42cardiac muscle hypertrophy (GO:0003300)3.18078758
43negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.16522119
44regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.16008343
45endocardial cushion morphogenesis (GO:0003203)3.15507450
46regulation of relaxation of muscle (GO:1901077)3.15263370
47embryonic foregut morphogenesis (GO:0048617)3.15120454
48primitive streak formation (GO:0090009)3.14679929
49lateral sprouting from an epithelium (GO:0060601)3.10844123
50planar cell polarity pathway involved in neural tube closure (GO:0090179)3.10454404
51renal filtration (GO:0097205)3.08171703
52cell migration involved in heart development (GO:0060973)3.05038266
53Notch signaling involved in heart development (GO:0061314)3.04855716
54positive regulation of DNA-dependent DNA replication (GO:2000105)3.02357229
55cellular response to epinephrine stimulus (GO:0071872)3.01345086
56nuclear pore complex assembly (GO:0051292)3.01261712
57regulation of telomere maintenance via telomerase (GO:0032210)3.00557717
58establishment or maintenance of monopolar cell polarity (GO:0061339)3.00182942
59establishment of monopolar cell polarity (GO:0061162)3.00182942
60relaxation of cardiac muscle (GO:0055119)3.00110370
61striated muscle hypertrophy (GO:0014897)2.99994927
62bundle of His cell to Purkinje myocyte communication (GO:0086069)2.98032456
63blood vessel maturation (GO:0001955)2.97808536
64mammary gland development (GO:0030879)2.97663457
65regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.96908551
66regulation of p38MAPK cascade (GO:1900744)2.96402537
67branching involved in mammary gland duct morphogenesis (GO:0060444)2.94510188
68axon extension involved in axon guidance (GO:0048846)2.93935855
69neuron projection extension involved in neuron projection guidance (GO:1902284)2.93935855
70glomerular basement membrane development (GO:0032836)2.92939902
71regulation of cardiac muscle cell contraction (GO:0086004)2.89403320
72regulation of hippo signaling (GO:0035330)2.89072646
73regulation of transforming growth factor beta2 production (GO:0032909)2.88305774
74sarcomere organization (GO:0045214)2.85913470
75lymphangiogenesis (GO:0001946)2.85777939
76positive regulation of odontogenesis (GO:0042482)2.85118419
77muscle hypertrophy (GO:0014896)2.84020483
78fibroblast migration (GO:0010761)2.82120345
79cartilage morphogenesis (GO:0060536)2.81436589
80cell migration involved in gastrulation (GO:0042074)2.79925807
81regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.79084582
82artery development (GO:0060840)2.78736809
83regulation of nuclear cell cycle DNA replication (GO:0033262)2.78011560
84cardiac chamber formation (GO:0003207)2.77977592
85negative regulation of hormone metabolic process (GO:0032351)2.77930305
86regulation of cardiac muscle hypertrophy (GO:0010611)2.77294209
87protein heterotrimerization (GO:0070208)2.76614948
88regulation of apoptotic process involved in morphogenesis (GO:1902337)2.75953048
89phagocytosis, recognition (GO:0006910)2.75244691
90nuclear pore organization (GO:0006999)2.74102553
91cell migration involved in sprouting angiogenesis (GO:0002042)2.73279907
92gap junction assembly (GO:0016264)2.73180314
93response to epinephrine (GO:0071871)2.73115976
94regulation of actin filament-based movement (GO:1903115)2.72735687
95regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.71536611
96smooth muscle tissue development (GO:0048745)2.70465512
97cell communication involved in cardiac conduction (GO:0086065)2.69315392
98cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.68957732
99positive regulation of macrophage cytokine production (GO:0060907)2.68748050
100cardiac epithelial to mesenchymal transition (GO:0060317)2.68575669
101negative regulation of cell cycle G2/M phase transition (GO:1902750)2.68091569
102endothelial cell morphogenesis (GO:0001886)2.67953936
103regulation of cardiac muscle cell differentiation (GO:2000725)2.67681549
104endocardial cushion development (GO:0003197)2.67635952
105hemidesmosome assembly (GO:0031581)2.67460137
106lymph vessel development (GO:0001945)2.67106874
107regulation of muscle hypertrophy (GO:0014743)2.66498443
108positive regulation of muscle hypertrophy (GO:0014742)2.66094726
109positive regulation of cardiac muscle hypertrophy (GO:0010613)2.66094726
110embryonic heart tube development (GO:0035050)2.65547710
111positive regulation of glomerulus development (GO:0090193)2.64579527
112cardiac ventricle formation (GO:0003211)2.64381877
113regulation of endothelial cell differentiation (GO:0045601)2.64375087
114organ formation (GO:0048645)2.63975688
115regulation of the force of heart contraction (GO:0002026)2.62431569
116positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.61297348
117heart morphogenesis (GO:0003007)2.60608041
118actin-myosin filament sliding (GO:0033275)2.59925122
119muscle filament sliding (GO:0030049)2.59925122
120cardiac muscle cell proliferation (GO:0060038)2.59672487
121cardiac muscle tissue morphogenesis (GO:0055008)2.58568418
122atrioventricular valve morphogenesis (GO:0003181)2.58271009
123anterior/posterior axis specification (GO:0009948)2.57721108
124regulation of SMAD protein import into nucleus (GO:0060390)2.57666671
125cardiac muscle cell development (GO:0055013)2.57174028
126insulin-like growth factor receptor signaling pathway (GO:0048009)2.57113705
127morphogenesis of an epithelial sheet (GO:0002011)2.56789206
128regulation of mammary gland epithelial cell proliferation (GO:0033599)2.56770175
129trabecula formation (GO:0060343)2.56672373
130cardiac cell development (GO:0055006)2.56365106
131muscle organ morphogenesis (GO:0048644)2.56095942
132regulation of axon extension involved in axon guidance (GO:0048841)2.55903487
133regulation of posttranscriptional gene silencing (GO:0060147)2.55461268
134regulation of gene silencing by miRNA (GO:0060964)2.55461268
135regulation of gene silencing by RNA (GO:0060966)2.55461268
136vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.54720545
137negative regulation of cell fate commitment (GO:0010454)2.54663784
138negative regulation of chondrocyte differentiation (GO:0032331)2.54154564
139histone H4-K8 acetylation (GO:0043982)2.53926252
140histone H4-K5 acetylation (GO:0043981)2.53926252
141histone H4-K12 acetylation (GO:0043983)2.53867004
142head development (GO:0060322)2.52986889
143maintenance of protein location in nucleus (GO:0051457)2.52646514
144substrate adhesion-dependent cell spreading (GO:0034446)2.52547378
145regulation of steroid hormone biosynthetic process (GO:0090030)2.51690847
146renal system development (GO:0072001)2.51227487
147negative chemotaxis (GO:0050919)2.51197649
148regulation of response to osmotic stress (GO:0047484)2.51158023
149negative regulation of catenin import into nucleus (GO:0035414)2.50207404
150ventricular trabecula myocardium morphogenesis (GO:0003222)2.50136586
151embryonic skeletal joint morphogenesis (GO:0060272)2.49544145
152establishment of endothelial barrier (GO:0061028)2.48217983
153adult heart development (GO:0007512)2.48125680
154anterior/posterior axis specification, embryo (GO:0008595)2.47480230
155regulation of cardioblast proliferation (GO:0003264)2.47381666
156regulation of secondary heart field cardioblast proliferation (GO:0003266)2.47381666
157patterning of blood vessels (GO:0001569)2.47073096
158regulation of non-canonical Wnt signaling pathway (GO:2000050)2.46832577
159endothelial cell differentiation (GO:0045446)2.46698725
160regulation of muscle adaptation (GO:0043502)2.46525847
161pathway-restricted SMAD protein phosphorylation (GO:0060389)2.45723478
162positive regulation of cardiac muscle cell differentiation (GO:2000727)2.45666006
163cell surface receptor signaling pathway involved in heart development (GO:0061311)2.45185289
164metanephric mesenchyme development (GO:0072075)2.45182499
165cell fate commitment involved in formation of primary germ layer (GO:0060795)2.43598578
166anatomical structure regression (GO:0060033)2.43525182
167positive regulation of smoothened signaling pathway (GO:0045880)2.43157905
168endoderm formation (GO:0001706)2.43148960
169collagen fibril organization (GO:0030199)2.43095695
170chondrocyte proliferation (GO:0035988)2.42972482
171actin-mediated cell contraction (GO:0070252)2.42855936
172regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.42638970
173regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.42482258
174actomyosin structure organization (GO:0031032)2.42417621
175heart valve formation (GO:0003188)2.42242579
176lung vasculature development (GO:0060426)2.41992397
177lung lobe morphogenesis (GO:0060463)2.41246250

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.50676105
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.27193906
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.27193906
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.27193906
5TP63_19390658_ChIP-ChIP_HaCaT_Human3.29905542
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.19067072
7* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.89433650
8NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.80047830
9CDX2_19796622_ChIP-Seq_MESCs_Mouse2.77177218
10HIF1A_21447827_ChIP-Seq_MCF-7_Human2.75299860
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.73786437
12SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.69850483
13EZH2_22144423_ChIP-Seq_EOC_Human2.64898147
14E2F7_22180533_ChIP-Seq_HELA_Human2.60257247
15GBX2_23144817_ChIP-Seq_PC3_Human2.40090705
16ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.38049775
17WT1_19549856_ChIP-ChIP_CCG9911_Human2.18429998
18TCF3_18692474_ChIP-Seq_MEFs_Mouse2.16958688
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.15822818
20TCF3_18692474_ChIP-Seq_MESCs_Mouse2.13219610
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10978392
22NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.09650661
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.06118271
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.06055489
25SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.05115706
26SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.05114538
27SMAD_19615063_ChIP-ChIP_OVARY_Human2.02658941
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.99877370
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.97768454
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.92283573
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.91792710
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.91707160
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91223811
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.88435407
35NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.85082262
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.74596446
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68626113
38WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.67401340
39CDX2_20551321_ChIP-Seq_CACO-2_Human1.65052975
40TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.64779396
41HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.62866689
42ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.62247416
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.60638954
44NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.57405298
45NRF2_20460467_ChIP-Seq_MEFs_Mouse1.57405298
46ZFP281_27345836_Chip-Seq_ESCs_Mouse1.57312111
47SALL4_18804426_ChIP-ChIP_XEN_Mouse1.55942528
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.54991005
49* SMAD4_21799915_ChIP-Seq_A2780_Human1.54766001
50SOX2_18555785_ChIP-Seq_MESCs_Mouse1.50418515
51FOXM1_23109430_ChIP-Seq_U2OS_Human1.50115010
52SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.48956208
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.48322108
54SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.47591193
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46720566
56SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.46055001
57ISL1_27105846_Chip-Seq_CPCs_Mouse1.44636370
58BRD4_25478319_ChIP-Seq_HGPS_Human1.44575632
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43461009
60SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42970646
61FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.41037084
62TP53_16413492_ChIP-PET_HCT116_Human1.40977255
63TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.40897639
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.39875738
65TBX3_20139965_ChIP-Seq_ESCs_Mouse1.39550525
66NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.39524105
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38408612
68CTNNB1_20460455_ChIP-Seq_HCT116_Human1.37600831
69NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.37595934
70* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.37483026
71* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37341731
72* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37152434
73TBX3_20139965_ChIP-Seq_MESCs_Mouse1.36994311
74EP300_21415370_ChIP-Seq_HL-1_Mouse1.35875298
75FOXO3_23340844_ChIP-Seq_DLD1_Human1.35164725
76ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34920350
77CLOCK_20551151_ChIP-Seq_293T_Human1.33196588
78KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32541153
79POU5F1_16518401_ChIP-PET_MESCs_Mouse1.32083412
80* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31723086
81RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31366887
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.31074745
83* ARNT_22903824_ChIP-Seq_MCF-7_Human1.29665757
84* GATA2_21666600_ChIP-Seq_HMVEC_Human1.29128316
85EGR1_19374776_ChIP-ChIP_THP-1_Human1.28915939
86FOXM1_26456572_ChIP-Seq_MCF-7_Human1.28899883
87TP53_20018659_ChIP-ChIP_R1E_Mouse1.28866847
88POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28794270
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27667436
90RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27183900
91JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26958806
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26946184
93SMAD4_21741376_ChIP-Seq_HESCs_Human1.26396554
94TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26160381
95CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.26122064
96* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.25833743
97STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25710631
98* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25607267
99* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.24391976
100LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24227536
101NFIB_24661679_ChIP-Seq_LUNG_Mouse1.24191882
102P300_19829295_ChIP-Seq_ESCs_Human1.23644459
103* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22743943
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22481939
105ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22205230
106FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21941377
107SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.21640824
108ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20716272
109TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20285677
110RING1B_27294783_Chip-Seq_NPCs_Mouse1.19184168
111RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19142962
112RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17475759
113TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16458312
114PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15732002
115PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15524943
116NANOG_16153702_ChIP-ChIP_HESCs_Human1.14928622
117E2F4_17652178_ChIP-ChIP_JURKAT_Human1.14530706
118NANOG_18692474_ChIP-Seq_MESCs_Mouse1.14047620
119TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13648355
120MTF2_20144788_ChIP-Seq_MESCs_Mouse1.13365628
121RNF2_27304074_Chip-Seq_ESCs_Mouse1.12426677
122JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12160860
123NANOG_18692474_ChIP-Seq_MEFs_Mouse1.11267100
124TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11005206
125POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.10369555
126TP53_18474530_ChIP-ChIP_U2OS_Human1.10244123
127ESR1_20079471_ChIP-ChIP_T-47D_Human1.10017632
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09550333
129* STAT3_23295773_ChIP-Seq_U87_Human1.09435952
130* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08250241
131TCF4_18268006_ChIP-ChIP_LS174T_Human1.08219266
132MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.07711315
133MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06589202
134AR_21572438_ChIP-Seq_LNCaP_Human1.06406547
135SMAD3_21741376_ChIP-Seq_HESCs_Human1.06340887
136TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06015727
137* BCAT_22108803_ChIP-Seq_LS180_Human1.05292723
138TAF15_26573619_Chip-Seq_HEK293_Human1.03526663
139* SOX2_21211035_ChIP-Seq_LN229_Gbm1.02933924
140TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02499767
141CJUN_26792858_Chip-Seq_BT549_Human1.02219471
142TP53_22127205_ChIP-Seq_IMR90_Human1.01522057
143TBX20_22328084_ChIP-Seq_HEART_Mouse1.01164183
144TBX20_22080862_ChIP-Seq_HEART_Mouse1.01164183
145CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99472857
146* ELK3_25401928_ChIP-Seq_HUVEC_Human0.98987905
147KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98752306
148SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96639734
149NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95609182
150STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94800442
151PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93597534
152* NANOG_16518401_ChIP-PET_MESCs_Mouse0.93478416
153* AHR_22903824_ChIP-Seq_MCF-7_Human0.92702233
154SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92164576
155RNF2_18974828_ChIP-Seq_MESCs_Mouse0.90690190
156EZH2_18974828_ChIP-Seq_MESCs_Mouse0.90690190
157AR_21909140_ChIP-Seq_LNCAP_Human0.90549211
158STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89265535
159SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89228338
160SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89228338
161* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86677866

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane4.64923144
2MP0004145_abnormal_muscle_electrophysio3.34643752
3MP0003122_maternal_imprinting3.13977576
4MP0008438_abnormal_cutaneous_collagen3.13402316
5MP0003705_abnormal_hypodermis_morpholog2.90176338
6MP0010368_abnormal_lymphatic_system2.72896626
7MP0004215_abnormal_myocardial_fiber2.72103362
8MP0002254_reproductive_system_inflammat2.68993843
9MP0005623_abnormal_meninges_morphology2.62595362
10MP0003950_abnormal_plasma_membrane2.53900160
11MP0003941_abnormal_skin_development2.48381501
12MP0004036_abnormal_muscle_relaxation2.31652040
13MP0000751_myopathy2.29528983
14MP0004264_abnormal_extraembryonic_tissu2.11613956
15MP0003121_genomic_imprinting2.10410546
16MP0005503_abnormal_tendon_morphology2.09175431
17MP0008004_abnormal_stomach_pH2.03091395
18MP0010030_abnormal_orbit_morphology2.01813320
19MP0004510_myositis1.95008895
20MP0003828_pulmonary_edema1.94890224
21MP0006054_spinal_hemorrhage1.86125503
22MP0001661_extended_life_span1.85513695
23MP0005275_abnormal_skin_tensile1.82736738
24MP0003890_abnormal_embryonic-extraembry1.78693044
25MP0003123_paternal_imprinting1.68367533
26MP0004858_abnormal_nervous_system1.65095946
27MP0003935_abnormal_craniofacial_develop1.61861979
28MP0003385_abnormal_body_wall1.60922326
29MP0002127_abnormal_cardiovascular_syste1.60790592
30MP0000462_abnormal_digestive_system1.60323006
31MP0005508_abnormal_skeleton_morphology1.58856383
32MP0000749_muscle_degeneration1.57374930
33MP0005257_abnormal_intraocular_pressure1.56842532
34MP0000049_abnormal_middle_ear1.55069066
35MP0003279_aneurysm1.54499612
36MP0001293_anophthalmia1.53810087
37MP0003300_gastrointestinal_ulcer1.51576312
38MP0004084_abnormal_cardiac_muscle1.49313517
39MP0005620_abnormal_muscle_contractility1.45935129
40MP0002088_abnormal_embryonic_growth/wei1.45410500
41MP0002932_abnormal_joint_morphology1.45386839
42MP0001879_abnormal_lymphatic_vessel1.44817639
43MP0003119_abnormal_digestive_system1.44581786
44MP0002938_white_spotting1.43955050
45MP0003984_embryonic_growth_retardation1.42960620
46MP0002925_abnormal_cardiovascular_devel1.41951860
47MP0003566_abnormal_cell_adhesion1.40815842
48MP0002972_abnormal_cardiac_muscle1.40810824
49MP0004087_abnormal_muscle_fiber1.39027161
50MP0001672_abnormal_embryogenesis/_devel1.38732820
51MP0005380_embryogenesis_phenotype1.38732820
52MP0000428_abnormal_craniofacial_morphol1.38129419
53MP0004484_altered_response_of1.37985192
54MP0009250_abnormal_appendicular_skeleto1.37508614
55MP0000767_abnormal_smooth_muscle1.37226738
56MP0003942_abnormal_urinary_system1.36742773
57MP0005330_cardiomyopathy1.33123797
58MP0005248_abnormal_Harderian_gland1.32605725
59MP0002086_abnormal_extraembryonic_tissu1.31837743
60MP0000566_synostosis1.30580471
61MP0003937_abnormal_limbs/digits/tail_de1.29611986
62MP0000537_abnormal_urethra_morphology1.29501164
63MP0000762_abnormal_tongue_morphology1.27237493
64MP0000465_gastrointestinal_hemorrhage1.26578389
65MP0010352_gastrointestinal_tract_polyps1.26096733
66MP0003755_abnormal_palate_morphology1.24438506
67MP0002295_abnormal_pulmonary_circulatio1.22978426
68MP0000432_abnormal_head_morphology1.22881056
69MP0006138_congestive_heart_failure1.22639999
70MP0005595_abnormal_vascular_smooth1.22433336
71MP0009384_cardiac_valve_regurgitation1.22149509
72MP0002249_abnormal_larynx_morphology1.21896177
73MP0004197_abnormal_fetal_growth/weight/1.21647129
74MP0002108_abnormal_muscle_morphology1.21409116
75MP0002106_abnormal_muscle_physiology1.20955047
76MP0002332_abnormal_exercise_endurance1.20107416
77MP0001849_ear_inflammation1.18703078
78MP0000733_abnormal_muscle_development1.17526228
79MP0003567_abnormal_fetal_cardiomyocyte1.16843730
80MP0002233_abnormal_nose_morphology1.16783258
81MP0005369_muscle_phenotype1.16170776
82MP0000516_abnormal_urinary_system1.14459044
83MP0005367_renal/urinary_system_phenotyp1.14459044
84MP0006292_abnormal_olfactory_placode1.14130685
85MP0000747_muscle_weakness1.13318245
86MP0003115_abnormal_respiratory_system1.12667296
87MP0005187_abnormal_penis_morphology1.12372747
88MP0000534_abnormal_ureter_morphology1.12229298
89MP0008775_abnormal_heart_ventricle1.10529263
90MP0004085_abnormal_heartbeat1.10281930
91MP0010630_abnormal_cardiac_muscle1.10071192
92MP0000750_abnormal_muscle_regeneration1.09463886
93MP0001299_abnormal_eye_distance/1.09312795
94MP0002084_abnormal_developmental_patter1.08872777
95MP0002085_abnormal_embryonic_tissue1.08577527
96MP0002092_abnormal_eye_morphology1.08486078
97MP0005385_cardiovascular_system_phenoty1.07690088
98MP0001544_abnormal_cardiovascular_syste1.07690088
99MP0002116_abnormal_craniofacial_bone1.05837675
100MP0003283_abnormal_digestive_organ1.04694500
101MP0005167_abnormal_blood-brain_barrier1.04068189
102MP0002697_abnormal_eye_size1.03874963
103MP0002269_muscular_atrophy1.00899991
104MP0005165_increased_susceptibility_to1.00229904
105MP0001614_abnormal_blood_vessel0.99903067
106MP0000759_abnormal_skeletal_muscle0.99085892
107MP0000678_abnormal_parathyroid_gland0.98874530
108MP0000383_abnormal_hair_follicle0.97930223
109MP0003045_fibrosis0.96433908
110MP0000266_abnormal_heart_morphology0.95948715
111MP0004133_heterotaxia0.94539724
112MP0000013_abnormal_adipose_tissue0.94470257
113MP0001958_emphysema0.93676528
114MP0002098_abnormal_vibrissa_morphology0.92680510
115MP0001915_intracranial_hemorrhage0.92571801
116MP0002114_abnormal_axial_skeleton0.92055418
117MP0000163_abnormal_cartilage_morphology0.91575917
118MP0002822_catalepsy0.91518550
119MP0009703_decreased_birth_body0.90554231
120MP0002128_abnormal_blood_circulation0.90334159
121MP0003091_abnormal_cell_migration0.90116490
122* MP0002109_abnormal_limb_morphology0.88016046
123MP0004957_abnormal_blastocyst_morpholog0.87528665
124MP0008057_abnormal_DNA_replication0.86177124
125MP0001286_abnormal_eye_development0.86121480
126MP0001177_atelectasis0.85316413
127MP0005670_abnormal_white_adipose0.83739614
128MP0002896_abnormal_bone_mineralization0.82829012
129MP0002111_abnormal_tail_morphology0.82526526
130MP0005409_darkened_coat_color0.82073621
131MP0002638_abnormal_pupillary_reflex0.81687219
132MP0010678_abnormal_skin_adnexa0.81275808
133MP0002168_other_aberrant_phenotype0.80594910
134MP0001175_abnormal_lung_morphology0.80503707
135MP0005076_abnormal_cell_differentiation0.80469022
136MP0004130_abnormal_muscle_cell0.79669044
137MP0001784_abnormal_fluid_regulation0.78732440
138MP0005023_abnormal_wound_healing0.78239123
139MP0009053_abnormal_anal_canal0.76330305
140MP0002133_abnormal_respiratory_system0.72107815
141MP0005388_respiratory_system_phenotype0.72107815
142MP0004233_abnormal_muscle_weight0.71996605
143MP0002009_preneoplasia0.70106101

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)4.85850783
2Abnormality of the calf musculature (HP:0001430)4.18303726
3Hepatoblastoma (HP:0002884)4.09393655
4Right ventricular cardiomyopathy (HP:0011663)3.90868878
5Limited hip movement (HP:0008800)3.79574060
6Arterial tortuosity (HP:0005116)3.73115002
7Vascular tortuosity (HP:0004948)3.52877473
8Protrusio acetabuli (HP:0003179)3.34538238
9Bundle branch block (HP:0011710)3.34225542
10Increased connective tissue (HP:0009025)3.15690329
11Sudden death (HP:0001699)3.10338795
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.10193651
13Short 4th metacarpal (HP:0010044)3.10193651
14Cerebral aneurysm (HP:0004944)3.07371437
15Premature rupture of membranes (HP:0001788)3.01576346
16Broad metatarsal (HP:0001783)2.92047692
17Shallow orbits (HP:0000586)2.90192828
18Renal duplication (HP:0000075)2.79936638
19Preauricular pit (HP:0004467)2.77460614
20Periauricular skin pits (HP:0100277)2.77460614
21Hypoplasia of the iris (HP:0007676)2.77025591
22Ankle contracture (HP:0006466)2.70415728
23Atrial fibrillation (HP:0005110)2.68687666
24Lymphangioma (HP:0100764)2.66536593
25Nephroblastoma (Wilms tumor) (HP:0002667)2.60752785
26Vitreoretinal degeneration (HP:0000655)2.60572630
27Abnormality of the distal phalanx of the thumb (HP:0009617)2.60543479
28Embryonal renal neoplasm (HP:0011794)2.56399147
29Hyporeflexia of lower limbs (HP:0002600)2.47213646
30Follicular hyperkeratosis (HP:0007502)2.46686223
31Abnormality of the 4th metacarpal (HP:0010012)2.45045518
32Muscle fiber splitting (HP:0003555)2.44925318
33Abnormality of the lacrimal duct (HP:0011481)2.44913029
34Nasolacrimal duct obstruction (HP:0000579)2.44049801
35Midline defect of the nose (HP:0004122)2.40636194
36Lipoatrophy (HP:0100578)2.40118240
37Disproportionate tall stature (HP:0001519)2.39494175
38Overgrowth (HP:0001548)2.38772024
39Preaxial foot polydactyly (HP:0001841)2.38676419
40Supraventricular arrhythmia (HP:0005115)2.38474589
41Rib fusion (HP:0000902)2.38220938
42Abnormal atrioventricular conduction (HP:0005150)2.37979939
43Fused cervical vertebrae (HP:0002949)2.37513686
44Complement deficiency (HP:0004431)2.36604660
45Skin pits (HP:0100276)2.36153423
46Aortic dissection (HP:0002647)2.35487862
47Abnormality of the nasolacrimal system (HP:0000614)2.34642603
48Shawl scrotum (HP:0000049)2.34609621
49Mildly elevated creatine phosphokinase (HP:0008180)2.34288608
50Knee flexion contracture (HP:0006380)2.33387752
51Heart block (HP:0012722)2.33262115
52Mitral valve prolapse (HP:0001634)2.28101502
53Primary atrial arrhythmia (HP:0001692)2.27523154
54Vertebral clefting (HP:0008428)2.25800309
55Hypochromic microcytic anemia (HP:0004840)2.24569105
56Atrophic scars (HP:0001075)2.23993133
57Bicuspid aortic valve (HP:0001647)2.21576504
58Partial duplication of the phalanx of hand (HP:0009999)2.20170329
59Rectal fistula (HP:0100590)2.19823592
60Rectovaginal fistula (HP:0000143)2.19823592
61Papillary thyroid carcinoma (HP:0002895)2.19166300
62Cutaneous syndactyly (HP:0012725)2.18459503
63Mesomelia (HP:0003027)2.17465618
64Bifid tongue (HP:0010297)2.16871053
65Supernumerary ribs (HP:0005815)2.16407930
66Partial duplication of thumb phalanx (HP:0009944)2.16273356
67Abnormality of the pubic bones (HP:0003172)2.16014444
68Pulmonary artery stenosis (HP:0004415)2.12317240
69Short humerus (HP:0005792)2.11558281
70Supraventricular tachycardia (HP:0004755)2.11531867
71Ectopia lentis (HP:0001083)2.08408158
72Abnormality of the phalanges of the 2nd finger (HP:0009541)2.08288123
73Hypoalphalipoproteinemia (HP:0003233)2.06076891
74Skull defect (HP:0001362)2.06050738
75Intestinal fistula (HP:0100819)2.05897259
76Wide anterior fontanel (HP:0000260)2.05156400
77Aplasia involving bones of the extremities (HP:0009825)2.04973815
78Aplasia involving bones of the upper limbs (HP:0009823)2.04973815
79Aplasia of the phalanges of the hand (HP:0009802)2.04973815
80Vertebral arch anomaly (HP:0008438)2.00340928
81Neoplasm of the heart (HP:0100544)2.00108965
82Dilatation of the ascending aorta (HP:0005111)1.99604517
83Ependymoma (HP:0002888)1.98852429
84Aplasia/hypoplasia of the humerus (HP:0006507)1.97761372
85Multiple enchondromatosis (HP:0005701)1.95460988
86Neoplasm of striated muscle (HP:0009728)1.95147019
87Short 5th finger (HP:0009237)1.94873550
88Calf muscle hypertrophy (HP:0008981)1.93208433
89Ventricular tachycardia (HP:0004756)1.92305272
90Abnormal lung lobation (HP:0002101)1.91989517
91Syncope (HP:0001279)1.90717969
92Esophageal varix (HP:0002040)1.90258301
93Abnormality of complement system (HP:0005339)1.90200094
94Broad toe (HP:0001837)1.90187494
95Bladder diverticulum (HP:0000015)1.89986215
96Abnormal pancreas size (HP:0012094)1.88368207
97Coronal craniosynostosis (HP:0004440)1.88355764
98Mitral regurgitation (HP:0001653)1.87457334
99Chromosomal breakage induced by crosslinking agents (HP:0003221)1.87391992
100Supernumerary bones of the axial skeleton (HP:0009144)1.87265883
101Aortic aneurysm (HP:0004942)1.86780085
102Striae distensae (HP:0001065)1.85678996
103Aplasia cutis congenita (HP:0001057)1.84412785
104Rectal prolapse (HP:0002035)1.83744114
105Cervical subluxation (HP:0003308)1.82445633
106Bell-shaped thorax (HP:0001591)1.81930418
107Aneurysm (HP:0002617)1.80430285
108Broad thumb (HP:0011304)1.80133322
109Broad palm (HP:0001169)1.78953151
110Muscular dystrophy (HP:0003560)1.77699209
111Neonatal short-limb short stature (HP:0008921)1.77373563
112Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.75528328
113Abnormality of the phalanges of the hallux (HP:0010057)1.75494443
114Metatarsus adductus (HP:0001840)1.75056512
115Abnormality of the aortic arch (HP:0012303)1.75012286
116Soft skin (HP:0000977)1.72994770
117Bicornuate uterus (HP:0000813)1.72538830
118Spinal rigidity (HP:0003306)1.72493610
119Ulnar deviation of finger (HP:0009465)1.72491304
120Abnormality of the parietal bone (HP:0002696)1.72047228
121Visceral angiomatosis (HP:0100761)1.71768828
122Vaginal fistula (HP:0004320)1.71574615
123Dilated cardiomyopathy (HP:0001644)1.71320708
124Subacute progressive viral hepatitis (HP:0006572)1.70632960
125Increased variability in muscle fiber diameter (HP:0003557)1.70590936
126Joint laxity (HP:0001388)1.69421792
127Ventricular arrhythmia (HP:0004308)1.69318718
128Short middle phalanx of the 5th finger (HP:0004220)1.68546637
129Sprengel anomaly (HP:0000912)1.67548113
130Hemangiomatosis (HP:0007461)1.67454718
131Osteolytic defects of the hand bones (HP:0009699)1.67349285
132Osteolytic defects of the phalanges of the hand (HP:0009771)1.67349285
133Abnormality of dentin (HP:0010299)1.67094743
134Skin tags (HP:0010609)1.67070875
135Aplasia/Hypoplasia of the sternum (HP:0006714)1.66609664
136Abnormality of the astrocytes (HP:0100707)1.66343734
137Astrocytoma (HP:0009592)1.66343734
138Muscle hypertrophy of the lower extremities (HP:0008968)1.66172682
139Type 1 muscle fiber predominance (HP:0003803)1.66153468
140Hypoplastic ischia (HP:0003175)1.66056908
141Ulnar bowing (HP:0003031)1.66052530
142Capillary hemangiomas (HP:0005306)1.65263940
143Hypoventilation (HP:0002791)1.64619871
144Exotropia (HP:0000577)1.64577034
145Glioma (HP:0009733)1.63590553
146Asymmetry of the thorax (HP:0001555)1.63379196
147Difficulty running (HP:0009046)1.63360702
148Hip contracture (HP:0003273)1.62739826
149Chromsome breakage (HP:0040012)1.62477500
150Facial shape deformation (HP:0011334)1.61752679
151Potter facies (HP:0002009)1.61752679
152Trismus (HP:0000211)1.61680293
153Hematochezia (HP:0002573)1.61662854
154Atresia of the external auditory canal (HP:0000413)1.61135927
155Preauricular skin tag (HP:0000384)1.61134423
156Blue sclerae (HP:0000592)1.60878766
157Cutaneous finger syndactyly (HP:0010554)1.60792304
158Trigonocephaly (HP:0000243)1.59553875
159Large earlobe (HP:0009748)1.59205653
160Wrist flexion contracture (HP:0001239)1.58683525
161Portal hypertension (HP:0001409)1.58666452
162Pancreatic islet-cell hyperplasia (HP:0004510)1.58318578
163Turricephaly (HP:0000262)1.57719483
164Inguinal hernia (HP:0000023)1.57631433
165Spondylolisthesis (HP:0003302)1.57576834
166Anterior segment dysgenesis (HP:0007700)1.57465883
167Abnormality of the nasal septum (HP:0000419)1.57112128
168Abnormality of the salivary glands (HP:0010286)1.56496737
169Abnormality of the ischium (HP:0003174)1.56250222
170Wormian bones (HP:0002645)1.56214926
171Ectopic anus (HP:0004397)1.54746461

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.14755855
2TIE13.54463957
3TGFBR23.53109270
4LATS13.29705794
5ERN12.71042647
6GRK52.65032389
7RIPK12.42412913
8PDGFRA2.11247750
9GRK12.00838523
10TYRO31.90618806
11PAK41.79986188
12SIK11.79634543
13MAPK71.77732252
14STK101.74591695
15DDR21.72205926
16LATS21.65633632
17RET1.58728264
18WNK11.57694349
19TTK1.57179552
20FGFR31.55482126
21KDR1.54408950
22EPHA21.48503389
23EPHB21.45981657
24ADRBK21.44407330
25TRPM71.43025235
26TGFBR11.42016493
27STK38L1.35919644
28CDK71.33854951
29DMPK1.32929043
30STK31.32861409
31CSF1R1.30982230
32FER1.30911195
33GRK61.25185131
34AKT31.21403400
35CAMK41.20119422
36MATK1.18038895
37CAMK1D1.17099745
38TTN1.16837537
39PTK21.13865975
40PRKG21.12740512
41SGK21.12316024
42FGFR21.08615551
43MTOR1.07780358
44GRK71.06229181
45TRIB31.05250682
46NEK91.03317315
47EEF2K1.00102725
48CDK80.98175904
49PKN20.96422242
50BMPR1B0.96028853
51PTK60.93630554
52EIF2AK20.92148115
53MAP3K100.91443783
54EPHA30.90495244
55FRK0.88086607
56MELK0.86993061
57ERBB40.84083227
58AKT20.83789308
59ROCK10.83448286
60CDC42BPA0.82506059
61SGK2230.79065760
62SGK4940.79065760
63SGK30.78038520
64FGFR10.77874772
65PDGFRB0.76652685
66ADRBK10.76583113
67SIK30.76512090
68MOS0.76441552
69CASK0.76278734
70CHUK0.75772541
71CHEK20.75027674
72MAP3K60.74944350
73RPS6KB20.74666336
74STK390.74155156
75ZAK0.74115162
76TNIK0.72939001
77EPHB10.71044727
78STK380.70314795
79MAP3K70.69686575
80ERBB20.66892340
81JAK10.66651529
82MARK20.66357226
83PAK20.63126429
84CDK40.61775177
85IGF1R0.61412809
86PLK40.60108363
87MET0.60003003
88CSK0.57471868
89PRKCE0.54147395
90OBSCN0.53588479
91ROCK20.53187885
92INSRR0.52572651
93BRD40.52322366
94PLK10.52316628
95MARK30.51577948
96NLK0.50796944
97GSK3A0.50058699
98NTRK30.49930987
99CAMK1G0.49449876
100PDK20.49380713
101CHEK10.49354266
102MAPK120.48907480
103IRAK10.48413866
104MYLK0.48289458
105INSR0.47736921
106ERBB30.47709310
107CAMK10.47003872
108LMTK20.45312238
109PTK2B0.45101962
110FGFR40.43806067
111NUAK10.43676934
112NEK60.43468914
113NTRK10.43064402
114ACVR1B0.42270099
115EPHA40.42172043
116ATM0.42169991
117PRKD30.42118722
118CSNK1G10.41877254
119PRKAA10.41513130
120PRKAA20.41457554
121MAPK10.41374278
122BMX0.41057680
123STK240.38456192
124CDK60.38447056
125FLT30.38343494
126PNCK0.38331521
127KSR10.37711266
128CLK10.37387848
129AKT10.36814947
130CDK90.36033935
131PIK3CA0.36025817
132PRKD10.35034956
133ICK0.34999700
134BCR0.34974718
135PRKG10.33734115
136MAPK100.33164919
137MKNK10.31540507
138JAK20.31503787
139SRPK10.30944428
140CAMK2A0.30058040
141MAPK150.29098933
142MKNK20.28601863
143SRC0.27979149

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.46103560
2Basal cell carcinoma_Homo sapiens_hsa052172.75351921
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.71988816
4Adherens junction_Homo sapiens_hsa045202.71974515
5Small cell lung cancer_Homo sapiens_hsa052222.44987681
6Focal adhesion_Homo sapiens_hsa045102.43560348
7Protein digestion and absorption_Homo sapiens_hsa049742.40564789
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.23554307
9Hippo signaling pathway_Homo sapiens_hsa043902.18301410
10Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.08185794
11Hedgehog signaling pathway_Homo sapiens_hsa043402.06560019
12TGF-beta signaling pathway_Homo sapiens_hsa043501.88323750
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.87508777
14Dilated cardiomyopathy_Homo sapiens_hsa054141.84688575
15Proteoglycans in cancer_Homo sapiens_hsa052051.76822081
16Notch signaling pathway_Homo sapiens_hsa043301.75349881
17MicroRNAs in cancer_Homo sapiens_hsa052061.74087982
18Pathways in cancer_Homo sapiens_hsa052001.71369675
19PI3K-Akt signaling pathway_Homo sapiens_hsa041511.58377081
20Tight junction_Homo sapiens_hsa045301.49484340
21Amoebiasis_Homo sapiens_hsa051461.47984972
22Complement and coagulation cascades_Homo sapiens_hsa046101.42556532
23Wnt signaling pathway_Homo sapiens_hsa043101.40843528
24Rap1 signaling pathway_Homo sapiens_hsa040151.39930544
25Thyroid cancer_Homo sapiens_hsa052161.39862696
26AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.39141074
27Leukocyte transendothelial migration_Homo sapiens_hsa046701.35122644
28Lysine degradation_Homo sapiens_hsa003101.30785176
29Regulation of actin cytoskeleton_Homo sapiens_hsa048101.30611533
30Toxoplasmosis_Homo sapiens_hsa051451.30177800
31Vitamin B6 metabolism_Homo sapiens_hsa007501.29449774
32Viral myocarditis_Homo sapiens_hsa054161.26786979
33Circadian rhythm_Homo sapiens_hsa047101.25648838
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.23146683
35Thyroid hormone signaling pathway_Homo sapiens_hsa049191.19887848
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15959465
37Cell cycle_Homo sapiens_hsa041101.13226052
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.11694413
39Prostate cancer_Homo sapiens_hsa052151.09987422
40Ovarian steroidogenesis_Homo sapiens_hsa049131.09031893
41Axon guidance_Homo sapiens_hsa043601.08142877
42Galactose metabolism_Homo sapiens_hsa000521.06773869
43HTLV-I infection_Homo sapiens_hsa051661.06604293
44Arachidonic acid metabolism_Homo sapiens_hsa005901.06004734
45Melanoma_Homo sapiens_hsa052181.05618830
46mTOR signaling pathway_Homo sapiens_hsa041501.04497723
47Renin secretion_Homo sapiens_hsa049241.02202338
48PPAR signaling pathway_Homo sapiens_hsa033201.00987702
49Colorectal cancer_Homo sapiens_hsa052100.96566611
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96177854
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.95521403
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95045802
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94801510
54Fructose and mannose metabolism_Homo sapiens_hsa000510.92282364
55Dorso-ventral axis formation_Homo sapiens_hsa043200.92210438
56Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91217455
57mRNA surveillance pathway_Homo sapiens_hsa030150.90720787
58Steroid biosynthesis_Homo sapiens_hsa001000.90509899
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89710281
60Insulin resistance_Homo sapiens_hsa049310.84908448
61Pancreatic cancer_Homo sapiens_hsa052120.84259002
62Bladder cancer_Homo sapiens_hsa052190.83896650
63HIF-1 signaling pathway_Homo sapiens_hsa040660.83689195
64Gap junction_Homo sapiens_hsa045400.81289631
65Endometrial cancer_Homo sapiens_hsa052130.80208291
66p53 signaling pathway_Homo sapiens_hsa041150.80043516
67Calcium signaling pathway_Homo sapiens_hsa040200.79864183
68Glioma_Homo sapiens_hsa052140.79775675
69Mineral absorption_Homo sapiens_hsa049780.77610025
70Thyroid hormone synthesis_Homo sapiens_hsa049180.77259250
71Chronic myeloid leukemia_Homo sapiens_hsa052200.75813315
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75343298
73Ras signaling pathway_Homo sapiens_hsa040140.74837515
74Melanogenesis_Homo sapiens_hsa049160.74668759
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.74065542
76Malaria_Homo sapiens_hsa051440.73708751
77Insulin signaling pathway_Homo sapiens_hsa049100.73529023
78Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73117587
79Oxytocin signaling pathway_Homo sapiens_hsa049210.72665572
80AMPK signaling pathway_Homo sapiens_hsa041520.71458872
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68625423
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.67053473
83Renal cell carcinoma_Homo sapiens_hsa052110.65678011
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64354148
85Bile secretion_Homo sapiens_hsa049760.63428547
86Prion diseases_Homo sapiens_hsa050200.62706120
87Propanoate metabolism_Homo sapiens_hsa006400.62413045
88Herpes simplex infection_Homo sapiens_hsa051680.61027630
89Estrogen signaling pathway_Homo sapiens_hsa049150.60192931
90Fanconi anemia pathway_Homo sapiens_hsa034600.60070518
91ABC transporters_Homo sapiens_hsa020100.59530264
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59034082
93TNF signaling pathway_Homo sapiens_hsa046680.58891997
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58532849
95Histidine metabolism_Homo sapiens_hsa003400.56544859
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56105078
97Acute myeloid leukemia_Homo sapiens_hsa052210.55896747
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55468631
99African trypanosomiasis_Homo sapiens_hsa051430.54284270
100Gastric acid secretion_Homo sapiens_hsa049710.53777224
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.53501857
102Platelet activation_Homo sapiens_hsa046110.53300474
103RNA transport_Homo sapiens_hsa030130.52943175
104ErbB signaling pathway_Homo sapiens_hsa040120.52227797
105Circadian entrainment_Homo sapiens_hsa047130.51915275
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48979698
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.48130243
108cAMP signaling pathway_Homo sapiens_hsa040240.48100153
109Choline metabolism in cancer_Homo sapiens_hsa052310.48065727
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47344232
111VEGF signaling pathway_Homo sapiens_hsa043700.47173403
112Pancreatic secretion_Homo sapiens_hsa049720.47156845
113Apoptosis_Homo sapiens_hsa042100.46841226
114Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44049574
115Viral carcinogenesis_Homo sapiens_hsa052030.43573974
116FoxO signaling pathway_Homo sapiens_hsa040680.42224125
117RNA degradation_Homo sapiens_hsa030180.41871652
118Fatty acid biosynthesis_Homo sapiens_hsa000610.41756501
119Glycerolipid metabolism_Homo sapiens_hsa005610.41636658
120Tyrosine metabolism_Homo sapiens_hsa003500.41450423
121Salivary secretion_Homo sapiens_hsa049700.40772234
122NF-kappa B signaling pathway_Homo sapiens_hsa040640.40381569
123Influenza A_Homo sapiens_hsa051640.37819044
124Linoleic acid metabolism_Homo sapiens_hsa005910.37408558
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35612066
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35218379
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34258357
128MAPK signaling pathway_Homo sapiens_hsa040100.34122276
129RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33318032
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31716440
131Jak-STAT signaling pathway_Homo sapiens_hsa046300.31599214
132Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30822131
133Inositol phosphate metabolism_Homo sapiens_hsa005620.29931491

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