ADAMTSL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted protein and member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family. This protein lacks the metalloproteinase and disintegrin-like domains, which are typical of the ADAMTS family, but contains other ADAMTS domains, including the thrombospondin type 1 motif. This protein may have important functions in the extracellular matrix. Alternative splicing results in multiple transcript variants encoding distinct proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)5.04362255
2axon ensheathment in central nervous system (GO:0032291)5.04362255
3endodermal cell differentiation (GO:0035987)4.71296238
4bone trabecula formation (GO:0060346)4.38289334
5axon extension involved in axon guidance (GO:0048846)4.36340406
6neuron projection extension involved in neuron projection guidance (GO:1902284)4.36340406
7myelination in peripheral nervous system (GO:0022011)4.32154099
8peripheral nervous system axon ensheathment (GO:0032292)4.32154099
9substrate-dependent cell migration (GO:0006929)4.24934689
10cell migration involved in heart development (GO:0060973)4.17080157
11regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.01076897
12negative regulation of chondrocyte differentiation (GO:0032331)3.97606214
13protein heterotrimerization (GO:0070208)3.96753907
14collagen fibril organization (GO:0030199)3.96196237
15negative regulation of smooth muscle cell migration (GO:0014912)3.80004412
16cell adhesion mediated by integrin (GO:0033627)3.79357607
17axon ensheathment (GO:0008366)3.75965501
18ensheathment of neurons (GO:0007272)3.75965501
19extracellular matrix assembly (GO:0085029)3.75886254
20myelination (GO:0042552)3.71779867
21cell migration involved in sprouting angiogenesis (GO:0002042)3.67229372
22type B pancreatic cell proliferation (GO:0044342)3.66991642
23positive regulation of blood vessel endothelial cell migration (GO:0043536)3.55663827
24glomerular filtration (GO:0003094)3.54657858
25regulation of plasminogen activation (GO:0010755)3.54120644
26vascular endothelial growth factor signaling pathway (GO:0038084)3.50818743
27regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.41966097
28cellular response to vitamin (GO:0071295)3.41150002
29negative regulation of BMP signaling pathway (GO:0030514)3.36807320
30mesenchymal-epithelial cell signaling (GO:0060638)3.34797432
31wound healing, spreading of epidermal cells (GO:0035313)3.34596642
32regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.34045065
33negative regulation of nitric-oxide synthase activity (GO:0051001)3.32946106
34endothelial cell morphogenesis (GO:0001886)3.32202352
35planar cell polarity pathway involved in neural tube closure (GO:0090179)3.29864131
36axon extension (GO:0048675)3.27140542
37lymphangiogenesis (GO:0001946)3.25784815
38negative regulation of osteoblast proliferation (GO:0033689)3.22170579
39heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.19477099
40sequestering of extracellular ligand from receptor (GO:0035581)3.19356874
41dermatan sulfate metabolic process (GO:0030205)3.18657664
42actin filament depolymerization (GO:0030042)3.13526994
43apical protein localization (GO:0045176)3.12169120
44barbed-end actin filament capping (GO:0051016)3.10728909
45regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.09021070
46camera-type eye morphogenesis (GO:0048593)3.08059394
47negative regulation of protein localization to cell surface (GO:2000009)3.07733518
48renal filtration (GO:0097205)3.06571669
49peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.04886270
50cellular response to vitamin D (GO:0071305)3.02843895
51regulation of chondrocyte differentiation (GO:0032330)3.01091593
52cranial nerve morphogenesis (GO:0021602)2.99638266
53substrate adhesion-dependent cell spreading (GO:0034446)2.98382230
54cell-substrate junction assembly (GO:0007044)2.98260694
55extracellular matrix disassembly (GO:0022617)2.96788925
56positive regulation of cartilage development (GO:0061036)2.94975965
57middle ear morphogenesis (GO:0042474)2.94081768
58extracellular matrix organization (GO:0030198)2.93495112
59chondrocyte proliferation (GO:0035988)2.93320001
60negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.92743253
61lateral sprouting from an epithelium (GO:0060601)2.92719045
62dermatan sulfate biosynthetic process (GO:0030208)2.92583826
63extracellular structure organization (GO:0043062)2.92486843
64regulation of cartilage development (GO:0061035)2.88632069
65positive regulation of axon extension (GO:0045773)2.88453088
66negative regulation of cartilage development (GO:0061037)2.88423300
67myelin maintenance (GO:0043217)2.86981655
68venous blood vessel morphogenesis (GO:0048845)2.86821956
69extracellular negative regulation of signal transduction (GO:1900116)2.86651152
70extracellular regulation of signal transduction (GO:1900115)2.86651152
71protein retention in ER lumen (GO:0006621)2.86499287
72neuron projection extension (GO:1990138)2.85793431
73cochlea morphogenesis (GO:0090103)2.83018005
74glomerular visceral epithelial cell development (GO:0072015)2.82550149
75positive regulation of fibroblast migration (GO:0010763)2.82381822
76dopamine biosynthetic process (GO:0042416)2.82029383
77craniofacial suture morphogenesis (GO:0097094)2.80832413
78extracellular fibril organization (GO:0043206)2.80756154
79dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.80329232
80Golgi transport vesicle coating (GO:0048200)2.78577162
81COPI coating of Golgi vesicle (GO:0048205)2.78577162
82asymmetric protein localization (GO:0008105)2.78157522
83wound healing, spreading of cells (GO:0044319)2.76597771
84negative regulation of fatty acid transport (GO:2000192)2.76591834
85vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.76035958
86negative regulation of catenin import into nucleus (GO:0035414)2.75628989
87negative regulation of neurotransmitter transport (GO:0051589)2.73300222
88glycerophospholipid catabolic process (GO:0046475)2.73237831
89cardiac epithelial to mesenchymal transition (GO:0060317)2.73179569
90basement membrane organization (GO:0071711)2.72086705
91glial cell migration (GO:0008347)2.71284970
92maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.71159134
93negative chemotaxis (GO:0050919)2.70686745
94sprouting angiogenesis (GO:0002040)2.69363594
95regulation of osteoblast proliferation (GO:0033688)2.69056007
96plasma membrane repair (GO:0001778)2.67852554
97generation of neurons (GO:0048699)2.67701967
98neuron remodeling (GO:0016322)2.67652255
99facial nerve structural organization (GO:0021612)2.67258657
100smooth muscle tissue development (GO:0048745)2.65318707
101photoreceptor cell differentiation (GO:0046530)2.62182175
102eye photoreceptor cell differentiation (GO:0001754)2.62182175
103astrocyte development (GO:0014002)2.61434618
104axonal fasciculation (GO:0007413)2.61367161
105oligodendrocyte differentiation (GO:0048709)2.61190670
106cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.60805725
107negative regulation of axon extension involved in axon guidance (GO:0048843)2.60630886
108adhesion of symbiont to host cell (GO:0044650)2.59849492
109virion attachment to host cell (GO:0019062)2.59849492
110regulation of non-canonical Wnt signaling pathway (GO:2000050)2.58217799
111collagen metabolic process (GO:0032963)2.58180333
112retina vasculature morphogenesis in camera-type eye (GO:0061299)2.57179869
113collagen catabolic process (GO:0030574)2.55372209
114negative regulation of Rho protein signal transduction (GO:0035024)2.55226336
115limb bud formation (GO:0060174)2.53462885
116regulation of transforming growth factor beta2 production (GO:0032909)2.53395457
117metanephric mesenchyme development (GO:0072075)2.53246224
118long-chain fatty acid biosynthetic process (GO:0042759)2.52306027
119muscle cell migration (GO:0014812)2.52271486
120multicellular organismal macromolecule metabolic process (GO:0044259)2.49082160
121cranial suture morphogenesis (GO:0060363)2.44966188
122prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.43246595
123multicellular organismal metabolic process (GO:0044236)2.42591430
124face morphogenesis (GO:0060325)2.42447127
125kidney mesenchyme development (GO:0072074)2.42353331
126regulation of cardioblast differentiation (GO:0051890)2.41842796
127platelet-derived growth factor receptor signaling pathway (GO:0048008)2.40062837
128negative regulation of neurotransmitter secretion (GO:0046929)2.39403247
129blood vessel maturation (GO:0001955)2.38600874
130regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.37416827
131trabecula formation (GO:0060343)2.36662801
132multicellular organismal catabolic process (GO:0044243)2.34364995
133neuron recognition (GO:0008038)2.34331614
134regulation of axon extension involved in axon guidance (GO:0048841)2.32798231
135enteric nervous system development (GO:0048484)2.31097803
136import into cell (GO:0098657)2.30274257
137chondrocyte development (GO:0002063)2.30212946
138skin morphogenesis (GO:0043589)2.29675263
139organ growth (GO:0035265)2.29657485
140glomerular basement membrane development (GO:0032836)2.28736189
141short-term memory (GO:0007614)2.25159451
142negative regulation of embryonic development (GO:0045992)2.24582789
143G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.22509188
144negative regulation of epithelial to mesenchymal transition (GO:0010719)2.21342335
145negative regulation of JUN kinase activity (GO:0043508)2.21160906
146negative regulation of axon guidance (GO:1902668)2.20540135
147regulation of somitogenesis (GO:0014807)2.19980940
148embryonic forelimb morphogenesis (GO:0035115)2.18919396
149forelimb morphogenesis (GO:0035136)2.18279825
150microtubule severing (GO:0051013)2.14527930
151fatty acid elongation (GO:0030497)2.14381160
152cell proliferation involved in kidney development (GO:0072111)2.14194822
153keratan sulfate catabolic process (GO:0042340)2.14065873
154regulation of catenin import into nucleus (GO:0035412)2.12729951
155fibril organization (GO:0097435)2.12511634
156neuron cell-cell adhesion (GO:0007158)2.12271958
157embryonic cranial skeleton morphogenesis (GO:0048701)2.11952742
158negative regulation of adherens junction organization (GO:1903392)2.11784912
159negative regulation of focal adhesion assembly (GO:0051895)2.11784912
160negative regulation of cell junction assembly (GO:1901889)2.11784912
161mesodermal cell differentiation (GO:0048333)2.10776205
162cell proliferation involved in metanephros development (GO:0072203)2.10412520
163regulation of axon guidance (GO:1902667)2.10131587
164presynaptic membrane organization (GO:0097090)2.08407177
165negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.08144960

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RARG_19884340_ChIP-ChIP_MEFs_Mouse4.48148167
2EZH2_22144423_ChIP-Seq_EOC_Human3.19505484
3* BRD4_25478319_ChIP-Seq_HGPS_Human3.06339038
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.86447846
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.82988446
6RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.79764573
7* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.71881508
8GBX2_23144817_ChIP-Seq_PC3_Human2.46140007
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.42629546
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39062577
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39062577
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.28502655
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.25192727
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.17222346
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14147876
16AR_21572438_ChIP-Seq_LNCaP_Human2.13025874
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.11705861
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.10651859
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09578612
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.09231001
21* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.01281820
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.97218686
23CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.97208672
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.96074921
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.93080002
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.85907975
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.85130195
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82676888
29* EP300_21415370_ChIP-Seq_HL-1_Mouse1.82609643
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.76749131
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75517587
32RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.73647688
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.73239483
34* GATA2_21666600_ChIP-Seq_HMVEC_Human1.70983127
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70385051
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.69188323
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67500130
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63645998
39TP53_22127205_ChIP-Seq_IMR90_Human1.63309799
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63112539
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60370837
42CLOCK_20551151_ChIP-Seq_293T_Human1.59963079
43SMC1_22415368_ChIP-Seq_MEFs_Mouse1.59873201
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.58676355
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.56904177
46* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.55912461
47* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55824380
48JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51818754
49JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51532343
50HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.50849226
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.50341409
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.49594540
53P300_27058665_Chip-Seq_ZR-75-30cells_Human1.49486466
54* TP53_23651856_ChIP-Seq_MEFs_Mouse1.48535817
55TAF15_26573619_Chip-Seq_HEK293_Human1.47731754
56EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.47633291
57* CJUN_26792858_Chip-Seq_BT549_Human1.46641837
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46264155
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45771823
60SA1_22415368_ChIP-Seq_MEFs_Mouse1.43667330
61NFIB_24661679_ChIP-Seq_LUNG_Mouse1.42723578
62* CBX2_27304074_Chip-Seq_ESCs_Mouse1.42096643
63* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41904588
64CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.39691421
65TP53_16413492_ChIP-PET_HCT116_Human1.39630338
66SMC3_22415368_ChIP-Seq_MEFs_Mouse1.38640193
67SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.37491560
68SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.37491560
69MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.35798024
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35685082
71SOX9_24532713_ChIP-Seq_HFSC_Mouse1.34336803
72DROSHA_22980978_ChIP-Seq_HELA_Human1.33458307
73* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32798577
74* FUS_26573619_Chip-Seq_HEK293_Human1.31911389
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31594242
76SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.31246948
77HIF1A_21447827_ChIP-Seq_MCF-7_Human1.30372603
78* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29761229
79PPAR_26484153_Chip-Seq_NCI-H1993_Human1.28917274
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27083867
81* SMAD4_21799915_ChIP-Seq_A2780_Human1.26945228
82* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25875371
83AHR_22903824_ChIP-Seq_MCF-7_Human1.25727817
84ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.25473545
85UBF1/2_26484160_Chip-Seq_HMECs_Human1.24855926
86ESR1_20079471_ChIP-ChIP_T-47D_Human1.24130928
87WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23864243
88* TP53_18474530_ChIP-ChIP_U2OS_Human1.23796112
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.23447154
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22970455
91* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22201240
92UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21519136
93STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21341818
94* TBX20_22328084_ChIP-Seq_HEART_Mouse1.19922045
95* TBX20_22080862_ChIP-Seq_HEART_Mouse1.19922045
96ISL1_27105846_Chip-Seq_CPCs_Mouse1.18766639
97* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18560281
98NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17245535
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17245535
100* P300_19829295_ChIP-Seq_ESCs_Human1.16618803
101RNF2_27304074_Chip-Seq_NSC_Mouse1.16052308
102TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15934213
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15422414
104* STAT3_23295773_ChIP-Seq_U87_Human1.15058462
105STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14193984
106* SMAD3_21741376_ChIP-Seq_EPCs_Human1.14034370
107* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12626138
108RING1B_27294783_Chip-Seq_NPCs_Mouse1.12370552
109* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12044079
110RING1B_27294783_Chip-Seq_ESCs_Mouse1.10188211
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09459332
112SALL1_21062744_ChIP-ChIP_HESCs_Human1.09310173
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08962206
114ESR2_21235772_ChIP-Seq_MCF-7_Human1.08959951
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06723669
116MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06701187
117MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05478364
118ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05360178
119NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04917612
120ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03807397
121NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.03361268
122PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01493154
123NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01372638
124ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99866292
125KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99001681
126KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98979480
127TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98840776
128CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98463802
129TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97966436
130MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96035481
131* SOX2_21211035_ChIP-Seq_LN229_Gbm0.95859034
132GATA1_26923725_Chip-Seq_HPCs_Mouse0.95202759
133TP53_20018659_ChIP-ChIP_R1E_Mouse0.95172994
134FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94292909
135AR_19668381_ChIP-Seq_PC3_Human0.93944560
136TCF4_23295773_ChIP-Seq_U87_Human0.93566617
137LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93411590
138ESR1_21235772_ChIP-Seq_MCF-7_Human0.92395436
139AR_25329375_ChIP-Seq_VCAP_Human0.91992901
140* RUNX2_22187159_ChIP-Seq_PCA_Human0.91311800
141ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91233132
142* SMAD4_21741376_ChIP-Seq_HESCs_Human0.91204278
143* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90846673
144* KDM2B_26808549_Chip-Seq_REH_Human0.90471016
145NFI_21473784_ChIP-Seq_ESCs_Mouse0.90203129
146ER_23166858_ChIP-Seq_MCF-7_Human0.90190887
147TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.85494607
148PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.85313718
149SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.85123919
150POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83602346
151SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.82145507

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.83937212
2MP0005503_abnormal_tendon_morphology5.01750944
3MP0005275_abnormal_skin_tensile4.11198600
4MP0004272_abnormal_basement_membrane3.01691966
5MP0005623_abnormal_meninges_morphology2.33191326
6MP0009384_cardiac_valve_regurgitation2.31927292
7MP0003566_abnormal_cell_adhesion2.28409747
8MP0009250_abnormal_appendicular_skeleto2.22910483
9MP0003122_maternal_imprinting2.18019253
10MP0005171_absent_coat_pigmentation2.16253706
11MP0003950_abnormal_plasma_membrane2.09723495
12MP0001958_emphysema2.05914119
13MP0003385_abnormal_body_wall2.03108757
14MP0002108_abnormal_muscle_morphology1.94887950
15MP0005508_abnormal_skeleton_morphology1.90174324
16MP0000534_abnormal_ureter_morphology1.88386731
17MP0003279_aneurysm1.82583257
18MP0000920_abnormal_myelination1.74866617
19MP0000462_abnormal_digestive_system1.72436752
20MP0001299_abnormal_eye_distance/1.71393448
21MP0005257_abnormal_intraocular_pressure1.68988716
22MP0002295_abnormal_pulmonary_circulatio1.68926493
23MP0005023_abnormal_wound_healing1.67509115
24MP0000013_abnormal_adipose_tissue1.64506617
25MP0003937_abnormal_limbs/digits/tail_de1.64128715
26MP0004145_abnormal_muscle_electrophysio1.62795336
27MP0002249_abnormal_larynx_morphology1.59656153
28MP0009780_abnormal_chondrocyte_physiolo1.58533401
29MP0000751_myopathy1.55638602
30MP0003942_abnormal_urinary_system1.53975872
31MP0003121_genomic_imprinting1.49217467
32MP0004270_analgesia1.46249327
33MP0000749_muscle_degeneration1.42895358
34MP0001879_abnormal_lymphatic_vessel1.42346246
35MP0004134_abnormal_chest_morphology1.42192204
36MP0010386_abnormal_urinary_bladder1.42130643
37MP0010030_abnormal_orbit_morphology1.41286739
38MP0002932_abnormal_joint_morphology1.39728029
39MP0003755_abnormal_palate_morphology1.37786330
40MP0000733_abnormal_muscle_development1.36384470
41MP0001346_abnormal_lacrimal_gland1.33493838
42MP0004858_abnormal_nervous_system1.29326454
43MP0001529_abnormal_vocalization1.25601750
44MP0003123_paternal_imprinting1.24640087
45MP0001177_atelectasis1.22381983
46MP0001243_abnormal_dermal_layer1.21130292
47MP0000566_synostosis1.19558004
48MP0000778_abnormal_nervous_system1.18304164
49MP0000762_abnormal_tongue_morphology1.17490349
50MP0002282_abnormal_trachea_morphology1.17433305
51MP0002877_abnormal_melanocyte_morpholog1.15996845
52MP0010368_abnormal_lymphatic_system1.14720932
53MP0000767_abnormal_smooth_muscle1.13849772
54MP0003705_abnormal_hypodermis_morpholog1.13222880
55MP0000579_abnormal_nail_morphology1.08558613
56MP0005451_abnormal_body_composition1.06848183
57MP0003091_abnormal_cell_migration1.05247177
58MP0001486_abnormal_startle_reflex1.05004046
59MP0002233_abnormal_nose_morphology1.04453110
60MP0000163_abnormal_cartilage_morphology1.04005700
61MP0003283_abnormal_digestive_organ1.03419001
62MP0002938_white_spotting1.02316557
63MP0002109_abnormal_limb_morphology1.00449503
64MP0010678_abnormal_skin_adnexa1.00376144
65MP0002116_abnormal_craniofacial_bone0.98978071
66MP0006054_spinal_hemorrhage0.98695204
67MP0002115_abnormal_skeleton_extremities0.98210764
68MP0003329_amyloid_beta_deposits0.98190148
69MP0010352_gastrointestinal_tract_polyps0.97780436
70MP0006138_congestive_heart_failure0.97278457
71MP0003115_abnormal_respiratory_system0.96938515
72MP0003935_abnormal_craniofacial_develop0.96872880
73MP0001849_ear_inflammation0.96836523
74MP0003045_fibrosis0.95975717
75MP0005367_renal/urinary_system_phenotyp0.95880529
76MP0000516_abnormal_urinary_system0.95880529
77MP0003632_abnormal_nervous_system0.95214047
78MP0001348_abnormal_lacrimal_gland0.94978997
79MP0005390_skeleton_phenotype0.93745340
80MP0002168_other_aberrant_phenotype0.93694479
81MP0003880_abnormal_central_pattern0.93437427
82MP0004084_abnormal_cardiac_muscle0.93392162
83MP0002060_abnormal_skin_morphology0.93258883
84MP0004885_abnormal_endolymph0.91462282
85MP0002114_abnormal_axial_skeleton0.91116619
86MP0000003_abnormal_adipose_tissue0.89355746
87MP0000747_muscle_weakness0.89231691
88MP0000428_abnormal_craniofacial_morphol0.87786114
89MP0003941_abnormal_skin_development0.86388847
90MP0005388_respiratory_system_phenotype0.85160184
91MP0002133_abnormal_respiratory_system0.85160184
92MP0000432_abnormal_head_morphology0.85154594
93MP0005248_abnormal_Harderian_gland0.84582684
94MP0005369_muscle_phenotype0.84441835
95MP0002128_abnormal_blood_circulation0.83349802
96MP0005595_abnormal_vascular_smooth0.82985285
97MP0004036_abnormal_muscle_relaxation0.81052265
98MP0001340_abnormal_eyelid_morphology0.80965411
99MP0002653_abnormal_ependyma_morphology0.80663043
100MP0001614_abnormal_blood_vessel0.80183305
101MP0000383_abnormal_hair_follicle0.79890670
102MP0000049_abnormal_middle_ear0.79308063
103MP0004859_abnormal_synaptic_plasticity0.78953689
104MP0000759_abnormal_skeletal_muscle0.77179811
105MP0000955_abnormal_spinal_cord0.76569074
106MP0002734_abnormal_mechanical_nocicepti0.76395512
107MP0000537_abnormal_urethra_morphology0.76136724
108MP0001851_eye_inflammation0.75820450
109MP0005620_abnormal_muscle_contractility0.75513923
110MP0004484_altered_response_of0.75480678
111MP0003938_abnormal_ear_development0.74908903
112MP0001542_abnormal_bone_strength0.73526600
113MP0004233_abnormal_muscle_weight0.73470412
114MP0005197_abnormal_uvea_morphology0.73261085
115MP0001485_abnormal_pinna_reflex0.71860101
116MP0005408_hypopigmentation0.71840327
117MP0004087_abnormal_muscle_fiber0.71774917
118MP0009053_abnormal_anal_canal0.71761858
119MP0002896_abnormal_bone_mineralization0.71691865
120MP0000613_abnormal_salivary_gland0.71396043
121MP0002113_abnormal_skeleton_development0.70714297
122MP0002925_abnormal_cardiovascular_devel0.69063365
123MP0001175_abnormal_lung_morphology0.67593975
124MP0000750_abnormal_muscle_regeneration0.64959076
125MP0001270_distended_abdomen0.63027784
126MP0002933_joint_inflammation0.61685557
127MP0000538_abnormal_urinary_bladder0.60351048
128MP0002177_abnormal_outer_ear0.57321560
129MP0005193_abnormal_anterior_eye0.56840711
130MP0000467_abnormal_esophagus_morphology0.52431834
131MP0008789_abnormal_olfactory_epithelium0.52105084
132MP0000569_abnormal_digit_pigmentation0.51111489
133MP0005360_urolithiasis0.49334769
134MP0005164_abnormal_response_to0.47696562
135MP0003795_abnormal_bone_structure0.47489614
136MP0000266_abnormal_heart_morphology0.47410886

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.48380668
2Protrusio acetabuli (HP:0003179)5.09977009
3Aortic dissection (HP:0002647)4.73593173
4Shallow orbits (HP:0000586)4.27433399
5Broad metatarsal (HP:0001783)4.09375179
6Cervical subluxation (HP:0003308)4.01493625
7Abnormality of dentin (HP:0010299)3.57432490
8Ankle contracture (HP:0006466)3.48634028
9Muscle fiber splitting (HP:0003555)3.47316038
10Soft skin (HP:0000977)3.35902509
11Type 1 muscle fiber predominance (HP:0003803)3.22444959
12Aortic aneurysm (HP:0004942)3.17610144
13Biconcave vertebral bodies (HP:0004586)3.10557664
14Atrophic scars (HP:0001075)3.01784973
15Vascular tortuosity (HP:0004948)3.01735417
16Bowel diverticulosis (HP:0005222)2.99655105
17Vertebral compression fractures (HP:0002953)2.95936642
18Arterial tortuosity (HP:0005116)2.95369852
19Joint stiffness (HP:0001387)2.84848546
20Infantile muscular hypotonia (HP:0008947)2.79550712
21Round ear (HP:0100830)2.75016856
22Aortic valve stenosis (HP:0001650)2.70856361
23Hypoplasia of the iris (HP:0007676)2.67629095
24Mitral regurgitation (HP:0001653)2.66126110
25Follicular hyperkeratosis (HP:0007502)2.63888442
26Bladder diverticulum (HP:0000015)2.62225316
27Coronal craniosynostosis (HP:0004440)2.60721464
28Mitral valve prolapse (HP:0001634)2.60311762
29Neurofibrillary tangles (HP:0002185)2.57540804
30Hyperextensible skin (HP:0000974)2.57435946
31Spinal rigidity (HP:0003306)2.57037025
32Elbow flexion contracture (HP:0002987)2.55345090
33Peritonitis (HP:0002586)2.54744532
34Aplasia involving bones of the upper limbs (HP:0009823)2.54637528
35Aplasia of the phalanges of the hand (HP:0009802)2.54637528
36Aplasia involving bones of the extremities (HP:0009825)2.54637528
37Degeneration of the lateral corticospinal tracts (HP:0002314)2.49512156
38Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.49512156
39Bell-shaped thorax (HP:0001591)2.49002185
40Mitral stenosis (HP:0001718)2.45746117
41Abnormality of the acetabulum (HP:0003170)2.45067173
42Short nail (HP:0001799)2.42033675
43Fragile skin (HP:0001030)2.40735783
44Osteolytic defects of the hand bones (HP:0009699)2.40554393
45Osteolytic defects of the phalanges of the hand (HP:0009771)2.40554393
46Spinal cord lesions (HP:0100561)2.38872398
47Syringomyelia (HP:0003396)2.38872398
48Hypoventilation (HP:0002791)2.37908901
49Deformed tarsal bones (HP:0008119)2.34463340
50Ectopia lentis (HP:0001083)2.33380816
51Cardiovascular calcification (HP:0011915)2.30464405
52Wrist flexion contracture (HP:0001239)2.30126420
53Slender build (HP:0001533)2.29049830
54Wormian bones (HP:0002645)2.28811241
55Aneurysm (HP:0002617)2.28377521
56Increased variability in muscle fiber diameter (HP:0003557)2.28248929
57Thin bony cortex (HP:0002753)2.24826459
58Short hallux (HP:0010109)2.24373465
59Short 4th metacarpal (HP:0010044)2.24118880
60Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.24118880
61Pulmonary artery stenosis (HP:0004415)2.22813356
62Ulnar bowing (HP:0003031)2.22762016
63Genu recurvatum (HP:0002816)2.21267429
64Overgrowth (HP:0001548)2.20361849
65Calcaneovalgus deformity (HP:0001848)2.20146922
66Cerebral aneurysm (HP:0004944)2.19240483
67Narrow nasal bridge (HP:0000446)2.15866476
68Dilatation of the ascending aorta (HP:0005111)2.12576505
69Hip contracture (HP:0003273)2.12125548
70Abnormality of the 4th metacarpal (HP:0010012)2.10738472
71Limited hip movement (HP:0008800)2.09204046
72Abnormality of the phalanges of the 2nd finger (HP:0009541)2.07782882
73Buphthalmos (HP:0000557)2.07287996
74Neonatal short-limb short stature (HP:0008921)2.05481527
75Wide anterior fontanel (HP:0000260)2.05327099
76Flat cornea (HP:0007720)2.05197462
77Alacrima (HP:0000522)2.03034763
78Mesomelia (HP:0003027)2.02521423
79Spondylolisthesis (HP:0003302)2.00404718
80Cerebral inclusion bodies (HP:0100314)1.99958415
81Broad ribs (HP:0000885)1.99635878
82Generalized amyotrophy (HP:0003700)1.98228848
83Abnormality of the corticospinal tract (HP:0002492)1.97884157
84Onion bulb formation (HP:0003383)1.97525195
85Abnormality of the middle phalanges of the toes (HP:0010183)1.96483110
86Blue sclerae (HP:0000592)1.96331815
87Increased connective tissue (HP:0009025)1.96071806
88Aplasia/Hypoplasia of the hallux (HP:0008362)1.95146212
89Disproportionate tall stature (HP:0001519)1.94958074
90Ovoid vertebral bodies (HP:0003300)1.94123059
91Abnormality of skeletal muscle fiber size (HP:0012084)1.93336030
92Deviation of the hallux (HP:0010051)1.92912771
93Camptodactyly of toe (HP:0001836)1.92746854
94Mild short stature (HP:0003502)1.92496823
95Striae distensae (HP:0001065)1.91860293
96Joint laxity (HP:0001388)1.91365542
97Natal tooth (HP:0000695)1.90263012
98Hallux valgus (HP:0001822)1.89896104
99Humeroradial synostosis (HP:0003041)1.89546516
100Synostosis involving the elbow (HP:0003938)1.89546516
101Inguinal hernia (HP:0000023)1.88546337
102Abnormal delivery (HP:0001787)1.88513815
103Flexion contracture of toe (HP:0005830)1.86912015
104Joint contractures involving the joints of the feet (HP:0100492)1.86912015
105Flared iliac wings (HP:0002869)1.84510394
106Microglossia (HP:0000171)1.84447074
107Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.84264565
108Long toe (HP:0010511)1.84092717
109Midline defect of the nose (HP:0004122)1.82634994
110Adrenal hypoplasia (HP:0000835)1.82001195
111Osteoarthritis (HP:0002758)1.81975930
112Abnormality of the 2nd finger (HP:0004100)1.81389219
113Abnormal auditory evoked potentials (HP:0006958)1.81149425
114Morphological abnormality of the middle ear (HP:0008609)1.80379729
115Diastasis recti (HP:0001540)1.80174142
116Tarsal synostosis (HP:0008368)1.78862729
117Entropion (HP:0000621)1.78801167
118Symphalangism affecting the phalanges of the hand (HP:0009773)1.78762886
119Congenital glaucoma (HP:0001087)1.78619264
120Limb-girdle muscle weakness (HP:0003325)1.78244567
121Abnormality of skull ossification (HP:0002703)1.77559222
122Chin dimple (HP:0010751)1.76998262
123Mildly elevated creatine phosphokinase (HP:0008180)1.75407042
124Abnormality of the anterior chamber (HP:0000593)1.74975085
125Reduced subcutaneous adipose tissue (HP:0003758)1.74644708
126Upper limb amyotrophy (HP:0009129)1.73918135
127Distal upper limb amyotrophy (HP:0007149)1.73918135
128Nemaline bodies (HP:0003798)1.73760263
129Absent frontal sinuses (HP:0002688)1.73389591
130Delayed cranial suture closure (HP:0000270)1.72528037
131Protruding ear (HP:0000411)1.72234348
132Breech presentation (HP:0001623)1.71585009
133Sensory axonal neuropathy (HP:0003390)1.70796395
134Hyporeflexia of lower limbs (HP:0002600)1.70593254
135Myelomeningocele (HP:0002475)1.70392451
136Venous abnormality (HP:0002624)1.70154942
137Broad face (HP:0000283)1.70145222
138Venous insufficiency (HP:0005293)1.69752750
139Aortic regurgitation (HP:0001659)1.69516561
140Muscle fiber inclusion bodies (HP:0100299)1.68378920
141Synostosis involving bones of the lower limbs (HP:0009138)1.66396829
142Synostosis involving bones of the feet (HP:0009140)1.66396829
143Scapular winging (HP:0003691)1.64548414
144Knee flexion contracture (HP:0006380)1.64293387
145Increased corneal curvature (HP:0100692)1.62758706
146Keratoconus (HP:0000563)1.62758706
147Cutaneous finger syndactyly (HP:0010554)1.62636019
148Termporal pattern (HP:0011008)1.62467504

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK93.45973629
2LATS13.26163387
3LATS23.20588139
4STK393.19068686
5DDR22.90830808
6TRIB32.57951898
7TGFBR22.40452188
8FLT32.36154192
9DMPK2.34671863
10OXSR12.12259196
11MAPKAPK52.08123798
12MET1.98926778
13TESK11.98313043
14EPHB11.87136285
15FGFR21.85587553
16MAP3K91.81410603
17MUSK1.77089587
18ERBB41.76578836
19MYLK1.76394036
20PAK41.74710927
21PKN11.61852441
22PDGFRA1.58074713
23BCR1.56206990
24PRPF4B1.54889910
25NTRK11.53576246
26MOS1.50207622
27PAK61.50158733
28MAP2K31.46746845
29CASK1.42256394
30EPHB21.41546870
31MAP3K61.40403976
32CSNK1G11.38238843
33CSNK1A1L1.32972567
34WNK11.32923169
35ROCK21.32837841
36TTN1.32455678
37STK38L1.31194698
38MARK21.30930612
39RIPK11.30375512
40PIK3CG1.30130352
41PAK21.26373883
42KSR21.24676961
43CSNK1G31.24202981
44LIMK11.23462575
45EPHA31.22530230
46PAK31.19382571
47NEK61.16503790
48FER1.13170642
49TYRO31.12557925
50PHKG21.12119768
51PHKG11.12119768
52PIK3CA1.10071925
53PRKD31.08483723
54CSNK1G21.07540016
55PKN21.06425696
56TRPM71.06049247
57ERN11.06040287
58PTK2B1.05696293
59SGK2231.04462917
60SGK4941.04462917
61DYRK21.01093635
62ILK1.00424005
63MAP3K40.96438623
64LMTK20.96063232
65FGR0.95491818
66MTOR0.94209097
67CAMK1G0.91978823
68MAP3K130.91796101
69WNK40.90969253
70CDK80.89763689
71PTK20.87394795
72PDGFRB0.87295814
73FRK0.87099638
74AKT30.86751624
75MAPK130.86157777
76ROCK10.84594023
77BMPR1B0.84189427
78CAMK2A0.83200816
79STK30.81543788
80RET0.81321462
81TAOK10.77482009
82PLK20.77262293
83RPS6KA20.75799071
84ABL20.74480364
85EPHA40.73880784
86KSR10.73611499
87PNCK0.71410234
88PRKD20.70230137
89INSRR0.69616356
90MAP3K70.69188479
91NUAK10.68680890
92CDK140.67242729
93CAMK2G0.66290384
94CAMK2B0.65796185
95EEF2K0.65790325
96BRAF0.65059546
97CDK150.64639777
98NTRK20.64194111
99PRKD10.64035871
100MARK10.63321906
101ICK0.62850992
102CDK180.62683875
103PRKG20.62562572
104CAMK2D0.60463259
105CAMK1D0.59639662
106NEK20.58012401
107SIK10.57744860
108DAPK30.55991639
109PRKCE0.55985262
110MELK0.55099661
111ADRBK10.53972807
112CDK11A0.53601050
113MAP3K30.53058066
114GSK3A0.52606631
115STK380.51944901
116CDK120.47448096
117EPHA20.47372406
118CLK10.47063975
119MAP2K10.46389781
120ERBB30.45870887
121CDC42BPA0.45770181
122TGFBR10.45566076
123TIE10.45177467
124TTK0.45049528
125UHMK10.44876133
126ZAP700.44773679
127CDK30.44597228
128RAF10.44579493
129MAPK70.44183991
130PAK10.44125962
131CDK90.43869969
132CDK50.42238597
133PRKCH0.41183036
134DYRK1B0.36894011
135DYRK1A0.35689051
136PIM20.34960941
137MAPKAPK30.34608388
138JAK30.34011151
139SRC0.31239400
140KIT0.28740979
141FGFR40.27043778
142BMX0.26301883
143TAOK20.25016672
144MAPKAPK20.23921823
145RPS6KL10.23432850
146RPS6KC10.23432850
147MST1R0.23356298
148SCYL20.21447003

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.45641831
2ECM-receptor interaction_Homo sapiens_hsa045123.13187379
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.47996436
4Axon guidance_Homo sapiens_hsa043602.16914728
5Focal adhesion_Homo sapiens_hsa045102.06140916
6Dilated cardiomyopathy_Homo sapiens_hsa054141.83103458
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.82831618
8TGF-beta signaling pathway_Homo sapiens_hsa043501.82015225
9Hippo signaling pathway_Homo sapiens_hsa043901.78419651
10Ovarian steroidogenesis_Homo sapiens_hsa049131.75531694
11Protein digestion and absorption_Homo sapiens_hsa049741.71581695
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.70569560
13Basal cell carcinoma_Homo sapiens_hsa052171.69970079
14Hedgehog signaling pathway_Homo sapiens_hsa043401.69912588
15Ether lipid metabolism_Homo sapiens_hsa005651.64635273
16Vascular smooth muscle contraction_Homo sapiens_hsa042701.54155295
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.53927938
18Tight junction_Homo sapiens_hsa045301.50556495
19Wnt signaling pathway_Homo sapiens_hsa043101.47370000
20Renal cell carcinoma_Homo sapiens_hsa052111.47282374
21Cocaine addiction_Homo sapiens_hsa050301.41973172
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.38156222
23Dorso-ventral axis formation_Homo sapiens_hsa043201.37907827
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.36655148
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.31276381
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29774435
27Adherens junction_Homo sapiens_hsa045201.29064024
28Amoebiasis_Homo sapiens_hsa051461.26184251
29MicroRNAs in cancer_Homo sapiens_hsa052061.25349036
30Long-term depression_Homo sapiens_hsa047301.22901346
31Proteoglycans in cancer_Homo sapiens_hsa052051.22667290
32Gap junction_Homo sapiens_hsa045401.21986594
33Vitamin B6 metabolism_Homo sapiens_hsa007501.21132457
34Other glycan degradation_Homo sapiens_hsa005111.20403930
35Melanogenesis_Homo sapiens_hsa049161.18146505
36Regulation of actin cytoskeleton_Homo sapiens_hsa048101.16192407
37Chronic myeloid leukemia_Homo sapiens_hsa052201.15323091
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.14958927
39GnRH signaling pathway_Homo sapiens_hsa049121.13041367
40PI3K-Akt signaling pathway_Homo sapiens_hsa041511.12558837
41Malaria_Homo sapiens_hsa051441.11288172
42Ras signaling pathway_Homo sapiens_hsa040141.08491413
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03427096
44Choline metabolism in cancer_Homo sapiens_hsa052311.02148137
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01607210
46Renin secretion_Homo sapiens_hsa049241.01197090
47ErbB signaling pathway_Homo sapiens_hsa040121.01092182
48Serotonergic synapse_Homo sapiens_hsa047261.00951638
49Phospholipase D signaling pathway_Homo sapiens_hsa040721.00542434
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99952735
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98906657
52Linoleic acid metabolism_Homo sapiens_hsa005910.98303807
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98230560
54p53 signaling pathway_Homo sapiens_hsa041150.96154302
55cAMP signaling pathway_Homo sapiens_hsa040240.95939739
56Amphetamine addiction_Homo sapiens_hsa050310.93932739
57Glutamatergic synapse_Homo sapiens_hsa047240.93570311
58Estrogen signaling pathway_Homo sapiens_hsa049150.92650840
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92615004
60Prostate cancer_Homo sapiens_hsa052150.92512375
61Fatty acid elongation_Homo sapiens_hsa000620.92484521
62Salivary secretion_Homo sapiens_hsa049700.92248090
63Pancreatic cancer_Homo sapiens_hsa052120.91460319
64Rap1 signaling pathway_Homo sapiens_hsa040150.91187779
65Oxytocin signaling pathway_Homo sapiens_hsa049210.89528170
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.88690426
67Pathways in cancer_Homo sapiens_hsa052000.85761948
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85661471
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84974721
70Circadian entrainment_Homo sapiens_hsa047130.84686958
71MAPK signaling pathway_Homo sapiens_hsa040100.84445663
72Steroid biosynthesis_Homo sapiens_hsa001000.84379450
73Shigellosis_Homo sapiens_hsa051310.84278010
74Morphine addiction_Homo sapiens_hsa050320.82103097
75Melanoma_Homo sapiens_hsa052180.82009728
76Nicotine addiction_Homo sapiens_hsa050330.81451942
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80944720
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.80934766
79GABAergic synapse_Homo sapiens_hsa047270.80863057
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.80054369
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79397870
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77220092
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76405096
84N-Glycan biosynthesis_Homo sapiens_hsa005100.75696851
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74887969
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73471387
87Dopaminergic synapse_Homo sapiens_hsa047280.73332879
88Glioma_Homo sapiens_hsa052140.72862739
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72823404
90Gastric acid secretion_Homo sapiens_hsa049710.71216717
91Platelet activation_Homo sapiens_hsa046110.71110350
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69480070
93Sphingolipid metabolism_Homo sapiens_hsa006000.68499982
94Circadian rhythm_Homo sapiens_hsa047100.67878503
95mTOR signaling pathway_Homo sapiens_hsa041500.67813107
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67345066
97Endocytosis_Homo sapiens_hsa041440.66841789
98Small cell lung cancer_Homo sapiens_hsa052220.66318425
99Calcium signaling pathway_Homo sapiens_hsa040200.65003878
100Cholinergic synapse_Homo sapiens_hsa047250.64726701
101Lysine degradation_Homo sapiens_hsa003100.64720104
102Bladder cancer_Homo sapiens_hsa052190.63387373
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.62972519
104Prion diseases_Homo sapiens_hsa050200.62564528
105Phototransduction_Homo sapiens_hsa047440.61778044
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61548234
107Notch signaling pathway_Homo sapiens_hsa043300.60554552
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.59632993
109Insulin secretion_Homo sapiens_hsa049110.59292459
110Vibrio cholerae infection_Homo sapiens_hsa051100.59148689
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57703461
112Thyroid hormone synthesis_Homo sapiens_hsa049180.57260515
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57157763
114Arachidonic acid metabolism_Homo sapiens_hsa005900.55776117
115Colorectal cancer_Homo sapiens_hsa052100.53954044
116VEGF signaling pathway_Homo sapiens_hsa043700.53269649
117Oocyte meiosis_Homo sapiens_hsa041140.52561243
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52340003
119Taste transduction_Homo sapiens_hsa047420.52321310
120Arginine and proline metabolism_Homo sapiens_hsa003300.50219717
121Renin-angiotensin system_Homo sapiens_hsa046140.49204771
122HTLV-I infection_Homo sapiens_hsa051660.45823942
123Endometrial cancer_Homo sapiens_hsa052130.45051487
124Prolactin signaling pathway_Homo sapiens_hsa049170.44546738
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40612023
126TNF signaling pathway_Homo sapiens_hsa046680.39488171
127Thyroid cancer_Homo sapiens_hsa052160.39335646
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38497468
129AMPK signaling pathway_Homo sapiens_hsa041520.38194854
130FoxO signaling pathway_Homo sapiens_hsa040680.37915011
131Salmonella infection_Homo sapiens_hsa051320.34229377
132Lysosome_Homo sapiens_hsa041420.33390817
133Glucagon signaling pathway_Homo sapiens_hsa049220.33380585

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