ADAMTSL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) and ADAMTS-like protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene lacks the protease domain, and is therefore of a member of the the ADAMTS-like protein subfamily. It is a secreted glycoprotein that binds the cell surface and extracellular matrix; it also interacts with latent transforming growth factor beta binding protein 1. Mutations in this gene have been associated with geleophysic dysplasia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)5.40915448
2peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)5.18828292
3myofibril assembly (GO:0030239)4.61295479
4sarcomere organization (GO:0045214)4.60415294
5negative regulation of cytosolic calcium ion concentration (GO:0051481)4.09941759
6glucocorticoid biosynthetic process (GO:0006704)4.08089699
7regulation of actin filament-based movement (GO:1903115)3.81785269
8actin-myosin filament sliding (GO:0033275)3.78324789
9muscle filament sliding (GO:0030049)3.78324789
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.75832135
11heart trabecula formation (GO:0060347)3.73924695
12cardiac muscle contraction (GO:0060048)3.68852487
13surfactant homeostasis (GO:0043129)3.67465318
14membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.64393293
15blood vessel maturation (GO:0001955)3.62738040
16lymph vessel development (GO:0001945)3.59586585
17cardiac muscle hypertrophy (GO:0003300)3.59263563
18venous blood vessel morphogenesis (GO:0048845)3.55162458
19striated muscle hypertrophy (GO:0014897)3.54195719
20regulation of sarcomere organization (GO:0060297)3.53411487
21exogenous drug catabolic process (GO:0042738)3.51121707
22chemical homeostasis within a tissue (GO:0048875)3.49240662
23regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.45874531
24drug catabolic process (GO:0042737)3.44730259
25retina vasculature morphogenesis in camera-type eye (GO:0061299)3.42985507
26cardiac muscle tissue morphogenesis (GO:0055008)3.42555417
27plasma membrane repair (GO:0001778)3.36906654
28synaptic vesicle docking involved in exocytosis (GO:0016081)3.33981025
29actomyosin structure organization (GO:0031032)3.33371160
30negative regulation of complement activation (GO:0045916)3.31742412
31regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.29027270
32reverse cholesterol transport (GO:0043691)3.27498127
33vascular endothelial growth factor signaling pathway (GO:0038084)3.26528970
34negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.25518826
35regulation of relaxation of muscle (GO:1901077)3.23178646
36regulation of endothelial cell differentiation (GO:0045601)3.21391912
37ventricular cardiac muscle cell action potential (GO:0086005)3.20721418
38actin-mediated cell contraction (GO:0070252)3.20327181
39muscle hypertrophy (GO:0014896)3.19586164
40atrioventricular valve morphogenesis (GO:0003181)3.16111455
41negative regulation of heart growth (GO:0061117)3.15896627
42negative regulation of cardiac muscle tissue growth (GO:0055022)3.15896627
43ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.15153348
44regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.14813001
45dendritic spine morphogenesis (GO:0060997)3.14548082
46negative regulation of potassium ion transmembrane transport (GO:1901380)3.11152037
47cellular ketone body metabolic process (GO:0046950)3.09407141
48negative regulation of protein activation cascade (GO:2000258)3.09314382
49cardiac muscle cell development (GO:0055013)3.09311169
50epoxygenase P450 pathway (GO:0019373)3.09041957
51lymphangiogenesis (GO:0001946)3.08627213
52glucocorticoid metabolic process (GO:0008211)3.08044065
53oxygen transport (GO:0015671)3.08033349
54muscle tissue morphogenesis (GO:0060415)3.05735633
55regulation of skeletal muscle contraction (GO:0014819)3.03912898
56synaptic vesicle maturation (GO:0016188)3.00844418
57regulation of cardiac muscle cell contraction (GO:0086004)2.99659047
58complement activation, classical pathway (GO:0006958)2.98109505
59regulation of cell communication by electrical coupling (GO:0010649)2.97679134
60bundle of His cell to Purkinje myocyte communication (GO:0086069)2.96570709
61cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.96081179
62oxidative demethylation (GO:0070989)2.95032370
63positive regulation of endothelial cell differentiation (GO:0045603)2.94097929
64regulation of cardiac muscle cell differentiation (GO:2000725)2.94008143
65striated muscle contraction (GO:0006941)2.92803467
66neurotransmitter-gated ion channel clustering (GO:0072578)2.92653673
67endocardial cushion morphogenesis (GO:0003203)2.91407193
68glomerular basement membrane development (GO:0032836)2.90727623
69trabecula formation (GO:0060343)2.89845016
70cardiac cell development (GO:0055006)2.88757908
71auditory receptor cell stereocilium organization (GO:0060088)2.88075782
72adult heart development (GO:0007512)2.85251709
73high-density lipoprotein particle remodeling (GO:0034375)2.84445706
74regulation of cardioblast differentiation (GO:0051890)2.83826738
75positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.83468557
76regulation of synapse maturation (GO:0090128)2.81248616
77regulation of the force of heart contraction (GO:0002026)2.80799098
78regulation of apoptotic cell clearance (GO:2000425)2.79342542
79cGMP biosynthetic process (GO:0006182)2.78946240
80regulation of striated muscle contraction (GO:0006942)2.77383899
81gamma-aminobutyric acid transport (GO:0015812)2.77090217
82tricarboxylic acid cycle (GO:0006099)2.76641823
83regulation of cholesterol esterification (GO:0010872)2.76111912
84regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.76078662
85regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.74504163
86regulation of female receptivity (GO:0045924)2.73376438
87complement activation (GO:0006956)2.73303764
88ethanol oxidation (GO:0006069)2.72511961
89cardiac muscle adaptation (GO:0014887)2.72483336
90cardiac muscle hypertrophy in response to stress (GO:0014898)2.72483336
91muscle hypertrophy in response to stress (GO:0003299)2.72483336
92cell communication involved in cardiac conduction (GO:0086065)2.72375333
93L-phenylalanine catabolic process (GO:0006559)2.71720823
94erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.71720823
95omega-hydroxylase P450 pathway (GO:0097267)2.70875039
96ketone body metabolic process (GO:1902224)2.70811668
97auditory behavior (GO:0031223)2.70580631
98triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.70403726
99toxin metabolic process (GO:0009404)2.68415816
100positive regulation of vasculogenesis (GO:2001214)2.67755410
101protein activation cascade (GO:0072376)2.66784538
102glyoxylate metabolic process (GO:0046487)2.66205632
103opsonization (GO:0008228)2.63893829
104negative regulation of synaptic transmission, GABAergic (GO:0032229)2.63290689
105negative regulation of cardiac muscle hypertrophy (GO:0010614)2.62897775
106glomerular filtration (GO:0003094)2.61010150
107aromatic amino acid family catabolic process (GO:0009074)2.60057792
108regulation of complement activation (GO:0030449)2.58836974
109macroautophagy (GO:0016236)2.57976578
110lysine metabolic process (GO:0006553)2.57722921
111lysine catabolic process (GO:0006554)2.57722921
112actin filament-based movement (GO:0030048)2.57059047
113endocardial cushion development (GO:0003197)2.56269983
114regulation of protein activation cascade (GO:2000257)2.55264145
115neuronal action potential propagation (GO:0019227)2.54409213
116regulation of beta-amyloid formation (GO:1902003)2.54249524
117axon ensheathment in central nervous system (GO:0032291)2.53687547
118central nervous system myelination (GO:0022010)2.53687547
119glutamate secretion (GO:0014047)2.53344271
120cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.52584550
121regulation of membrane repolarization (GO:0060306)2.52251837
122plasma lipoprotein particle remodeling (GO:0034369)2.52230436
123protein-lipid complex remodeling (GO:0034368)2.52230436
124macromolecular complex remodeling (GO:0034367)2.52230436
125cardiac conduction (GO:0061337)2.51470528
126detection of calcium ion (GO:0005513)2.51370837
127regulation of vasculogenesis (GO:2001212)2.50908357
128indole-containing compound catabolic process (GO:0042436)2.49690653
129indolalkylamine catabolic process (GO:0046218)2.49690653
130tryptophan catabolic process (GO:0006569)2.49690653
131proline transport (GO:0015824)2.49349850
132membrane depolarization during action potential (GO:0086010)2.48858962
133regulation of cardiac muscle contraction (GO:0055117)2.48293285
134positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.47435448
135vocalization behavior (GO:0071625)2.47327041
136cell communication by electrical coupling (GO:0010644)2.47044416
137positive regulation of fatty acid oxidation (GO:0046321)2.46847406
138mesenchyme morphogenesis (GO:0072132)2.46550638
139cardiac chamber formation (GO:0003207)2.46425080
140negative regulation of protein localization to cell surface (GO:2000009)2.46060012
141homocysteine metabolic process (GO:0050667)2.45902169
142outflow tract septum morphogenesis (GO:0003148)2.44370517
143gas transport (GO:0015669)2.44040320
144neurotransmitter secretion (GO:0007269)2.43942760
145cellular sodium ion homeostasis (GO:0006883)2.42711261
146alanine transport (GO:0032328)2.42372618
147nitric oxide mediated signal transduction (GO:0007263)2.41247940
148fatty acid transmembrane transport (GO:1902001)2.41132901
149cardiac muscle cell action potential (GO:0086001)2.40851500
150positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.40206558
151positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.38105220
152glycerophospholipid catabolic process (GO:0046475)2.37927628
153positive regulation of synapse maturation (GO:0090129)2.37844134
154primary amino compound metabolic process (GO:1901160)2.37605168
155carnitine shuttle (GO:0006853)2.36021773
156renal filtration (GO:0097205)2.35788427
157phenylpropanoid metabolic process (GO:0009698)2.35719020
158complement activation, alternative pathway (GO:0006957)2.35413221
159nephron tubule morphogenesis (GO:0072078)2.34063388
160nephron epithelium morphogenesis (GO:0072088)2.34063388
161regulation of heart rate (GO:0002027)2.34062242
162cardiac muscle cell action potential involved in contraction (GO:0086002)2.34048068
163cGMP metabolic process (GO:0046068)2.33636832
1642-oxoglutarate metabolic process (GO:0006103)2.33366631
165regulation of triglyceride biosynthetic process (GO:0010866)2.33292553
166female mating behavior (GO:0060180)2.32533784
167response to misfolded protein (GO:0051788)2.32135596
168regulation of glucokinase activity (GO:0033131)2.31772940
169regulation of hexokinase activity (GO:1903299)2.31772940
170potassium ion import (GO:0010107)2.30346613
171S-adenosylmethionine metabolic process (GO:0046500)2.29581146
172response to dietary excess (GO:0002021)2.28584776
173postsynaptic membrane organization (GO:0001941)2.27864564
174potassium ion export (GO:0071435)2.27155017
175atrial cardiac muscle cell action potential (GO:0086014)2.27105718
176benzene-containing compound metabolic process (GO:0042537)2.26127962
177regulation of short-term neuronal synaptic plasticity (GO:0048172)2.26103668
178triglyceride homeostasis (GO:0070328)2.26097925
179acylglycerol homeostasis (GO:0055090)2.26097925
180renal tubule morphogenesis (GO:0061333)2.25378555
181blood coagulation, intrinsic pathway (GO:0007597)2.24879282
182synaptic vesicle exocytosis (GO:0016079)2.24628262
183regulation of heart rate by cardiac conduction (GO:0086091)2.22599543
184sodium-independent organic anion transport (GO:0043252)2.22558483
185neuronal ion channel clustering (GO:0045161)2.22128063
186negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.21669390
187regulation of fibrinolysis (GO:0051917)2.21519994
188potassium ion transmembrane transport (GO:0071805)2.20838181
189cellular potassium ion transport (GO:0071804)2.20838181

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.19114873
2TRIM28_21343339_ChIP-Seq_HEK293_Human2.88387542
3GBX2_23144817_ChIP-Seq_PC3_Human2.70501757
4EP300_21415370_ChIP-Seq_HL-1_Mouse2.66891384
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.51061625
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.27382539
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.21916942
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.20447991
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.19533759
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.17048097
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.16497454
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.12551920
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.12551920
14GATA1_22025678_ChIP-Seq_K562_Human2.09818857
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.08131011
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.02833299
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00928347
18SMAD_19615063_ChIP-ChIP_OVARY_Human1.97072845
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.91114921
20AR_21572438_ChIP-Seq_LNCaP_Human1.90694488
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.88726103
22REST_21632747_ChIP-Seq_MESCs_Mouse1.85494911
23MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85179927
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.81865336
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.77391518
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73241387
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67777197
28LXR_22158963_ChIP-Seq_LIVER_Mouse1.66150106
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.65015602
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.64819486
31DROSHA_22980978_ChIP-Seq_HELA_Human1.63999950
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.63762737
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.60962357
34ESR1_20079471_ChIP-ChIP_T-47D_Human1.56128223
35RXR_22158963_ChIP-Seq_LIVER_Mouse1.55960222
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.54951510
37CLOCK_20551151_ChIP-Seq_293T_Human1.54415037
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.53000551
39* TBX20_22328084_ChIP-Seq_HEART_Mouse1.50487361
40* TBX20_22080862_ChIP-Seq_HEART_Mouse1.50487361
41FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.50422781
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.50209827
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48461471
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48146223
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.47556431
46BCAT_22108803_ChIP-Seq_LS180_Human1.42818163
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.42388132
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.41816059
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39653198
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39377339
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.38965915
52ESR1_21235772_ChIP-Seq_MCF-7_Human1.38909928
53ZNF274_21170338_ChIP-Seq_K562_Hela1.31903446
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31347003
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29693679
56AHR_22903824_ChIP-Seq_MCF-7_Human1.28686235
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23034602
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.22133042
59EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21613795
60PPARA_22158963_ChIP-Seq_LIVER_Mouse1.20230327
61NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18181388
62NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18181388
63CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17844568
64SMAD4_21799915_ChIP-Seq_A2780_Human1.17187626
65RARB_27405468_Chip-Seq_BRAIN_Mouse1.16953103
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15963500
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15402488
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14378583
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14348428
70TAF15_26573619_Chip-Seq_HEK293_Human1.14196397
71TCF4_23295773_ChIP-Seq_U87_Human1.13939867
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10896003
73EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10869739
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10571749
75MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09868766
76CJUN_26792858_Chip-Seq_BT549_Human1.09814049
77CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08782531
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08707737
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08664893
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.06667036
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.05755765
82WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05354491
83TP53_18474530_ChIP-ChIP_U2OS_Human1.05244573
84IGF1R_20145208_ChIP-Seq_DFB_Human1.04942279
85ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04560600
86* CTCF_27219007_Chip-Seq_Bcells_Human1.04416706
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03606384
88STAT3_23295773_ChIP-Seq_U87_Human1.02576692
89RING1B_27294783_Chip-Seq_ESCs_Mouse1.02258866
90POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01226826
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01052322
92VDR_22108803_ChIP-Seq_LS180_Human1.00397626
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00143019
94RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99158078
95TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98854233
96EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98299738
97SMAD4_21741376_ChIP-Seq_HESCs_Human0.98195484
98SOX2_21211035_ChIP-Seq_LN229_Gbm0.97324033
99P300_19829295_ChIP-Seq_ESCs_Human0.97025210
100TP53_16413492_ChIP-PET_HCT116_Human0.96782008
101* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96054885
102* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96054885
103WT1_19549856_ChIP-ChIP_CCG9911_Human0.95840725
104SMAD3_21741376_ChIP-Seq_HESCs_Human0.95719007
105ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95619655
106SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95334901
107CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95287744
108PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94527484
109TCF4_22108803_ChIP-Seq_LS180_Human0.94249373
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92028487
111* RUNX2_22187159_ChIP-Seq_PCA_Human0.91769155
112* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90645052
113AR_25329375_ChIP-Seq_VCAP_Human0.90049385
114SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89797753
115AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89772729
116SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88355348
117SMAD4_21741376_ChIP-Seq_EPCs_Human0.87497825
118* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87421749
119DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86609725
120MYC_19829295_ChIP-Seq_ESCs_Human0.86603677
121KDM2B_26808549_Chip-Seq_REH_Human0.86309965
122ETV2_25802403_ChIP-Seq_MESCs_Mouse0.86188767
123AR_19668381_ChIP-Seq_PC3_Human0.86109903
124MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.86030092
125ISL1_27105846_Chip-Seq_CPCs_Mouse0.85966093
126SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85687296
127FOXA2_19822575_ChIP-Seq_HepG2_Human0.85255618
128EGR1_23403033_ChIP-Seq_LIVER_Mouse0.84086824
129TCF4_18268006_ChIP-ChIP_LS174T_Human0.83638972
130ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83619753
131UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82068425
132TP53_20018659_ChIP-ChIP_R1E_Mouse0.81458310
133SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81084065
134CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.80808311
135CBX2_27304074_Chip-Seq_ESCs_Mouse0.80222476
136TOP2B_26459242_ChIP-Seq_MCF-7_Human0.80157223

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.19687762
2MP0000751_myopathy4.44381720
3MP0004084_abnormal_cardiac_muscle4.20138860
4MP0008438_abnormal_cutaneous_collagen3.77500222
5MP0005503_abnormal_tendon_morphology3.73036647
6MP0010368_abnormal_lymphatic_system3.49069757
7MP0004215_abnormal_myocardial_fiber3.03929320
8MP0004036_abnormal_muscle_relaxation3.00527683
9MP0005275_abnormal_skin_tensile2.99128859
10MP0004272_abnormal_basement_membrane2.91026637
11MP0005330_cardiomyopathy2.75069197
12MP0000749_muscle_degeneration2.71506863
13MP0001958_emphysema2.65244149
14MP0001879_abnormal_lymphatic_vessel2.38765960
15MP0003787_abnormal_imprinting2.33694543
16MP0002972_abnormal_cardiac_muscle2.29898593
17MP0008775_abnormal_heart_ventricle2.28248063
18MP0004484_altered_response_of2.15090581
19MP0006138_congestive_heart_failure2.10964653
20MP0001544_abnormal_cardiovascular_syste2.10959656
21MP0005385_cardiovascular_system_phenoty2.10959656
22MP0004270_analgesia2.08082875
23MP0002138_abnormal_hepatobiliary_system2.05991036
24MP0003646_muscle_fatigue2.04546810
25MP0005620_abnormal_muscle_contractility1.96759612
26MP0005360_urolithiasis1.96347762
27MP0009745_abnormal_behavioral_response1.91389972
28MP0002272_abnormal_nervous_system1.90208596
29MP0004087_abnormal_muscle_fiber1.89125867
30MP0008875_abnormal_xenobiotic_pharmacok1.88505482
31MP0003828_pulmonary_edema1.86805857
32MP0004085_abnormal_heartbeat1.86472771
33MP0005646_abnormal_pituitary_gland1.84125820
34MP0001486_abnormal_startle_reflex1.82845832
35MP0002064_seizures1.77033903
36MP0001501_abnormal_sleep_pattern1.76599892
37MP0004510_myositis1.76464615
38MP0002638_abnormal_pupillary_reflex1.76045546
39MP0001968_abnormal_touch/_nociception1.74226718
40MP0000750_abnormal_muscle_regeneration1.72787866
41MP0002127_abnormal_cardiovascular_syste1.69667462
42MP0002108_abnormal_muscle_morphology1.62515918
43MP0005167_abnormal_blood-brain_barrier1.60033180
44MP0002139_abnormal_hepatobiliary_system1.52939050
45MP0002063_abnormal_learning/memory/cond1.51931187
46MP0002572_abnormal_emotion/affect_behav1.50937689
47MP0003690_abnormal_glial_cell1.49736868
48MP0005085_abnormal_gallbladder_physiolo1.49294577
49MP0010630_abnormal_cardiac_muscle1.49038578
50MP0003137_abnormal_impulse_conducting1.48835139
51MP0005551_abnormal_eye_electrophysiolog1.48739786
52MP0005369_muscle_phenotype1.46662625
53MP0001502_abnormal_circadian_rhythm1.45942808
54MP0002106_abnormal_muscle_physiology1.43498476
55MP0001984_abnormal_olfaction1.42474623
56MP0003279_aneurysm1.41888696
57MP0004043_abnormal_pH_regulation1.39393183
58MP0001485_abnormal_pinna_reflex1.37854901
59MP0005379_endocrine/exocrine_gland_phen1.34807007
60MP0002822_catalepsy1.34654352
61MP0003283_abnormal_digestive_organ1.32446547
62MP0002269_muscular_atrophy1.30848357
63MP0004885_abnormal_endolymph1.30726948
64MP0003705_abnormal_hypodermis_morpholog1.30409210
65MP0001986_abnormal_taste_sensitivity1.28424449
66MP0002734_abnormal_mechanical_nocicepti1.26899351
67MP0001661_extended_life_span1.24804198
68MP0005595_abnormal_vascular_smooth1.24793872
69MP0004130_abnormal_muscle_cell1.24309624
70MP0005423_abnormal_somatic_nervous1.23898586
71MP0002733_abnormal_thermal_nociception1.22087220
72MP0000767_abnormal_smooth_muscle1.21327552
73MP0002557_abnormal_social/conspecific_i1.20974309
74MP0003045_fibrosis1.20639193
75MP0005365_abnormal_bile_salt1.19388041
76MP0005165_increased_susceptibility_to1.18937154
77MP0000747_muscle_weakness1.18138660
78MP0001970_abnormal_pain_threshold1.17568490
79MP0004145_abnormal_muscle_electrophysio1.16734068
80MP0003633_abnormal_nervous_system1.15774603
81MP0006276_abnormal_autonomic_nervous1.15668155
82MP0002254_reproductive_system_inflammat1.14455718
83MP0008004_abnormal_stomach_pH1.14075367
84MP0008872_abnormal_physiological_respon1.13663495
85MP0003329_amyloid_beta_deposits1.11562816
86MP0000639_abnormal_adrenal_gland1.10452859
87MP0003221_abnormal_cardiomyocyte_apopto1.09697232
88MP0000759_abnormal_skeletal_muscle1.09046986
89MP0000230_abnormal_systemic_arterial1.07798656
90MP0009780_abnormal_chondrocyte_physiolo1.07712910
91MP0003252_abnormal_bile_duct1.05975102
92MP0005386_behavior/neurological_phenoty1.03953199
93MP0004924_abnormal_behavior1.03953199
94MP0002295_abnormal_pulmonary_circulatio1.03048176
95MP0004233_abnormal_muscle_weight0.99707066
96MP0002332_abnormal_exercise_endurance0.98340578
97MP0004782_abnormal_surfactant_physiolog0.97796264
98MP0002078_abnormal_glucose_homeostasis0.97140625
99MP0003122_maternal_imprinting0.96440027
100MP0005448_abnormal_energy_balance0.95806467
101MP0003724_increased_susceptibility_to0.95275169
102MP0005623_abnormal_meninges_morphology0.95250135
103MP0005535_abnormal_body_temperature0.95052196
104MP0009840_abnormal_foam_cell0.94731419
105MP0002933_joint_inflammation0.93330980
106MP0002090_abnormal_vision0.91588042
107MP0002735_abnormal_chemical_nociception0.91173453
108MP0003172_abnormal_lysosome_physiology0.90886212
109MP0003950_abnormal_plasma_membrane0.90138364
110MP0003880_abnormal_central_pattern0.89068443
111MP0010329_abnormal_lipoprotein_level0.88618041
112MP0000013_abnormal_adipose_tissue0.88388529
113MP0004019_abnormal_vitamin_homeostasis0.87601063
114MP0002128_abnormal_blood_circulation0.86706275
115MP0000343_altered_response_to0.86645784
116MP0003631_nervous_system_phenotype0.85531834
117MP0002693_abnormal_pancreas_physiology0.85377336
118MP0005332_abnormal_amino_acid0.83942537
119MP0002229_neurodegeneration0.82985369
120MP0005171_absent_coat_pigmentation0.81287149
121MP0002133_abnormal_respiratory_system0.80819287
122MP0005388_respiratory_system_phenotype0.80819287
123MP0003878_abnormal_ear_physiology0.80242251
124MP0005377_hearing/vestibular/ear_phenot0.80242251
125MP0008877_abnormal_DNA_methylation0.78705289
126MP0003191_abnormal_cellular_cholesterol0.78677796
127MP0000266_abnormal_heart_morphology0.78190057
128MP0002971_abnormal_brown_adipose0.77347172
129MP0002067_abnormal_sensory_capabilities0.77311879
130MP0003136_yellow_coat_color0.76582816
131MP0003567_abnormal_fetal_cardiomyocyte0.73928470
132MP0005083_abnormal_biliary_tract0.72070985
133MP0000249_abnormal_blood_vessel0.69217314
134MP0005508_abnormal_skeleton_morphology0.67555233
135MP0003566_abnormal_cell_adhesion0.65079882
136MP0001756_abnormal_urination0.62207307
137MP0003195_calcinosis0.61769873
138MP0004883_abnormal_blood_vessel0.61307780
139MP0008874_decreased_physiological_sensi0.59956148
140MP0002089_abnormal_postnatal_growth/wei0.59602122
141MP0001765_abnormal_ion_homeostasis0.56846151
142MP0005670_abnormal_white_adipose0.55964215
143MP0002060_abnormal_skin_morphology0.54654756
144MP0003635_abnormal_synaptic_transmissio0.54265302
145MP0002925_abnormal_cardiovascular_devel0.54246213
146MP0010386_abnormal_urinary_bladder0.53831267
147MP0002118_abnormal_lipid_homeostasis0.53636044
148MP0003115_abnormal_respiratory_system0.52934153
149MP0003879_abnormal_hair_cell0.51976044
150MP0002234_abnormal_pharynx_morphology0.51925981
151MP0000534_abnormal_ureter_morphology0.51421341
152MP0002876_abnormal_thyroid_physiology0.51256260
153MP0004859_abnormal_synaptic_plasticity0.48614073
154MP0002909_abnormal_adrenal_gland0.48311645
155MP0009046_muscle_twitch0.47578477

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.27271675
2Glomerulonephritis (HP:0000099)5.83732718
3Abnormality of complement system (HP:0005339)4.95095298
4Muscle fiber splitting (HP:0003555)4.64898926
5Ventricular tachycardia (HP:0004756)4.63621833
6Atrial fibrillation (HP:0005110)4.63038688
7Abnormality of the calf musculature (HP:0001430)4.57294418
8Right ventricular cardiomyopathy (HP:0011663)4.47108775
9Calf muscle hypertrophy (HP:0008981)4.40368641
10Exercise-induced muscle cramps (HP:0003710)4.32290374
11Primary atrial arrhythmia (HP:0001692)4.26835845
12Broad metatarsal (HP:0001783)4.15202886
13Supraventricular arrhythmia (HP:0005115)4.05096312
14Supraventricular tachycardia (HP:0004755)4.04567501
15Lipoatrophy (HP:0100578)4.00211970
16Muscle hypertrophy of the lower extremities (HP:0008968)3.99532882
17Exercise-induced myalgia (HP:0003738)3.94485568
18Polycythemia (HP:0001901)3.87381012
19Increased connective tissue (HP:0009025)3.71689448
20Hyporeflexia of lower limbs (HP:0002600)3.67193285
21Syncope (HP:0001279)3.59785838
22EMG: myopathic abnormalities (HP:0003458)3.54293343
23Nephritis (HP:0000123)3.43114295
24Dilated cardiomyopathy (HP:0001644)3.20413956
25Prolonged QT interval (HP:0001657)3.14553508
26Hyperactive renin-angiotensin system (HP:0000841)3.04777292
27Prolonged partial thromboplastin time (HP:0003645)3.01815972
28Hematochezia (HP:0002573)2.99569926
29Hyperinsulinemic hypoglycemia (HP:0000825)2.98880654
30Spontaneous hematomas (HP:0007420)2.97370113
31Subaortic stenosis (HP:0001682)2.97184794
32Abnormality of the left ventricular outflow tract (HP:0011103)2.97184794
33Ventricular arrhythmia (HP:0004308)2.92095416
34Distal lower limb muscle weakness (HP:0009053)2.91024214
35Asymmetric septal hypertrophy (HP:0001670)2.80302611
36Focal seizures (HP:0007359)2.76927724
37Deep venous thrombosis (HP:0002625)2.75715585
38Protrusio acetabuli (HP:0003179)2.72819971
39Pulmonary artery stenosis (HP:0004415)2.69318310
40Abnormality of aromatic amino acid family metabolism (HP:0004338)2.68363166
41Hyperglycemia (HP:0003074)2.67526885
42Cerebral hemorrhage (HP:0001342)2.67098609
43Bundle branch block (HP:0011710)2.63002032
44Increased variability in muscle fiber diameter (HP:0003557)2.59925476
45Type 1 muscle fiber predominance (HP:0003803)2.59195477
46Febrile seizures (HP:0002373)2.58807860
47Palpitations (HP:0001962)2.56258756
48Late onset (HP:0003584)2.55841488
49Hyperventilation (HP:0002883)2.54801370
50Xanthomatosis (HP:0000991)2.54331899
51Large for gestational age (HP:0001520)2.54177571
52Complement deficiency (HP:0004431)2.54099796
53Abnormal drinking behavior (HP:0030082)2.50262313
54Polydipsia (HP:0001959)2.50262313
55Increased circulating renin level (HP:0000848)2.49521447
56Myoglobinuria (HP:0002913)2.48933873
57Skin nodule (HP:0200036)2.47017862
58Enlarged penis (HP:0000040)2.47000422
59Myokymia (HP:0002411)2.41801161
60Joint hemorrhage (HP:0005261)2.38875695
61Limb-girdle muscle atrophy (HP:0003797)2.38649008
62Action tremor (HP:0002345)2.37521770
63Hypokalemia (HP:0002900)2.34609443
64Abnormality of skeletal muscle fiber size (HP:0012084)2.32253347
65Hemiparesis (HP:0001269)2.31543817
66Esophageal varix (HP:0002040)2.29561305
67Muscular dystrophy (HP:0003560)2.29525905
68Mesangial abnormality (HP:0001966)2.29412294
69Progressive cerebellar ataxia (HP:0002073)2.29120309
70Heart block (HP:0012722)2.28210184
71Decreased circulating renin level (HP:0003351)2.27191167
72Ventricular fibrillation (HP:0001663)2.27151892
73Abnormality of potassium homeostasis (HP:0011042)2.26390617
74Central scotoma (HP:0000603)2.23736099
75Atrioventricular block (HP:0001678)2.23163281
76Visceral angiomatosis (HP:0100761)2.22864921
77Abnormal atrioventricular conduction (HP:0005150)2.22485132
78Ketoacidosis (HP:0001993)2.22480934
79Ankle contracture (HP:0006466)2.20915072
80Insulin-resistant diabetes mellitus (HP:0000831)2.18895109
81Renal salt wasting (HP:0000127)2.18438917
82Mildly elevated creatine phosphokinase (HP:0008180)2.18147118
83Abnormal urine output (HP:0012590)2.17545452
84Hypoglycemic seizures (HP:0002173)2.13582658
85Tubular atrophy (HP:0000092)2.12654366
86Cavernous hemangioma (HP:0001048)2.12400590
87Nephronophthisis (HP:0000090)2.10998945
88Gaze-evoked nystagmus (HP:0000640)2.10594962
89Abnormal EKG (HP:0003115)2.10379836
90Postural instability (HP:0002172)2.10330399
91Type II lissencephaly (HP:0007260)2.09673787
92Myotonia (HP:0002486)2.08853648
93Fair hair (HP:0002286)2.08797961
94Epileptiform EEG discharges (HP:0011182)2.08784680
95Retinal atrophy (HP:0001105)2.07509483
96EEG with generalized epileptiform discharges (HP:0011198)2.06821555
97Congenital sensorineural hearing impairment (HP:0008527)2.06697219
98Polyuria (HP:0000103)2.05232270
99Hypoglycemic coma (HP:0001325)2.04964552
100Arthropathy (HP:0003040)2.04205237
101Potter facies (HP:0002009)2.03872832
102Facial shape deformation (HP:0011334)2.03872832
103Epileptic encephalopathy (HP:0200134)2.03751720
104Hypoplastic ischia (HP:0003175)2.03481717
105Spinal rigidity (HP:0003306)2.03406153
106Hypsarrhythmia (HP:0002521)2.01502703
107Hypokalemic alkalosis (HP:0001949)2.01411479
108Abnormality of renin-angiotensin system (HP:0000847)2.01349218
109Lymphangioma (HP:0100764)2.00235150
110Cerebral palsy (HP:0100021)1.98923544
111Dysdiadochokinesis (HP:0002075)1.98016161
112Conjunctival telangiectasia (HP:0000524)1.95854390
113Double outlet right ventricle (HP:0001719)1.95773598
114Congenital malformation of the right heart (HP:0011723)1.95773598
115Hyperaldosteronism (HP:0000859)1.95549508
116Abnormality of renal excretion (HP:0011036)1.93991189
117Abnormality of the renal cortex (HP:0011035)1.93502047
118Gout (HP:0001997)1.93335715
119Abnormality of the renal medulla (HP:0100957)1.92962214
120Hemangiomatosis (HP:0007461)1.92099761
121Abnormality of fatty-acid metabolism (HP:0004359)1.89668583
122Hip contracture (HP:0003273)1.89543934
123Congenital stationary night blindness (HP:0007642)1.89266600
124Ketosis (HP:0001946)1.88725751
125Distal lower limb amyotrophy (HP:0008944)1.88593357
126Ankle clonus (HP:0011448)1.86177499
127Metabolic alkalosis (HP:0200114)1.86014061
128Abnormality of monocarboxylic acid metabolism (HP:0010996)1.85873638
129Premature rupture of membranes (HP:0001788)1.85853172
130* Congestive heart failure (HP:0001635)1.85730469
131Bulbar palsy (HP:0001283)1.85274215
132Systemic lupus erythematosus (HP:0002725)1.85187871
133Obstructive sleep apnea (HP:0002870)1.84841334
134Intention tremor (HP:0002080)1.82977007
135Left ventricular hypertrophy (HP:0001712)1.82027090
136Generalized muscle weakness (HP:0003324)1.81717718
137Hyperkalemia (HP:0002153)1.81483754
138Tachypnea (HP:0002789)1.81097161
139Difficulty running (HP:0009046)1.81037487
140Spontaneous abortion (HP:0005268)1.80183064
141Hypomagnesemia (HP:0002917)1.80026456
142Difficulty climbing stairs (HP:0003551)1.79785997
143Abnormality of the ischium (HP:0003174)1.79493581
144Sleep apnea (HP:0010535)1.79148560
145Sudden cardiac death (HP:0001645)1.78637775
146Generalized hypopigmentation of hair (HP:0011358)1.78633416
147* Mitral stenosis (HP:0001718)1.77965849
148Palmoplantar keratoderma (HP:0000982)1.76898301
149Recurrent gram-negative bacterial infections (HP:0005420)1.76608543
150Abnormal eating behavior (HP:0100738)1.76288957
151Hypoplastic left heart (HP:0004383)1.76061228
152Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.75569325
153Testicular atrophy (HP:0000029)1.75191721
154Centrally nucleated skeletal muscle fibers (HP:0003687)1.74459688
155Torticollis (HP:0000473)1.73148991
156Genetic anticipation (HP:0003743)1.73005593
157Striae distensae (HP:0001065)1.72773452
158Cerebral aneurysm (HP:0004944)1.72539004
159Tongue fasciculations (HP:0001308)1.71421514
160Aneurysm (HP:0002617)1.71245743
161Generalized tonic-clonic seizures (HP:0002069)1.71164566
162Camptodactyly of toe (HP:0001836)1.67644682
163Long toe (HP:0010511)1.67614436
164Cervical subluxation (HP:0003308)1.67480900
165Patent foramen ovale (HP:0001655)1.67137008
166Flat cornea (HP:0007720)1.66672082
167Focal motor seizures (HP:0011153)1.65169039
168Abnormality of the foot musculature (HP:0001436)1.62635735
169Abnormality of the nasal mucosa (HP:0000433)1.62582917
170Cholelithiasis (HP:0001081)1.62008585
171Limited hip movement (HP:0008800)1.61287022
172Hyperlipoproteinemia (HP:0010980)1.61075529

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.70258020
2FRK4.48197843
3CASK3.36081806
4MYLK3.19725092
5TGFBR23.05067860
6OBSCN2.90841716
7KDR2.56438392
8DAPK22.52626324
9TTN2.44896534
10BMPR1B2.14576396
11MARK12.10127703
12PHKG22.02193053
13PHKG12.02193053
14PTK2B1.92928106
15PDGFRA1.84585008
16MAP3K41.74464342
17BCKDK1.68501467
18EPHB21.67287374
19MAP2K61.61523710
20EPHA41.54465465
21STK38L1.53047301
22PIK3CA1.50243131
23WNK31.49808178
24PDK41.49599763
25PDK31.49599763
26NTRK21.46673569
27LMTK21.45445085
28DMPK1.45240646
29ADRBK21.43220339
30TNK21.43201189
31PINK11.42427735
32WNK41.40214156
33INSRR1.39998426
34MAP4K21.37776751
35PRPF4B1.35687911
36RIPK11.34187827
37MAP2K41.29052907
38MAP2K71.28186648
39FER1.24424758
40MAPK121.16845118
41GRK71.14259227
42GRK11.12750256
43NTRK31.12553385
44MAPK131.11015795
45MAP3K121.09811240
46ACVR1B1.07889621
47MAPK151.07052503
48FGFR21.06715433
49DAPK31.04629511
50PRKCH1.04074151
51PDK21.04012187
52MUSK1.03316378
53SIK11.01158836
54UHMK10.98559541
55PLK20.97007923
56ROCK10.96910360
57FGFR40.95444134
58ERBB20.94881711
59TRIB30.93891737
60PRKD10.92632184
61PKN10.92153685
62PAK30.88565939
63STK110.88405476
64MAP3K60.87595579
65CAMK2A0.85986052
66PRKCE0.84444051
67TGFBR10.83235024
68TAOK30.81899281
69AKT30.81299850
70OXSR10.79604348
71STK240.77962006
72CSK0.77923664
73STK390.77393511
74MAPK70.76512020
75CAMK2D0.76306549
76MAP3K50.74986885
77MAP3K70.74669800
78FGFR30.74619968
79ZAK0.73025352
80GRK50.70011482
81CDK50.69207129
82NLK0.67355531
83MST1R0.65723407
84PDGFRB0.65457279
85CDC42BPA0.64729488
86ROCK20.63502447
87PRKG10.62447471
88PRKD30.62261602
89MARK20.61511562
90STK380.61383019
91LATS10.58967783
92DAPK10.58361115
93CAMKK10.56019444
94PKN20.55572183
95CAMK10.55351161
96NME10.55282469
97PRKCZ0.54582893
98PNCK0.54150811
99ITK0.53292204
100PDK10.53048671
101SGK20.52458315
102PRKD20.52386066
103CAMK1G0.51842226
104ADRBK10.51268125
105CAMK40.50655226
106SIK20.49612631
107PRKACB0.48259261
108TRPM70.47570071
109HIPK20.47436555
110PRKG20.47068163
111SGK2230.46940887
112SGK4940.46940887
113SGK30.46923598
114RPS6KA30.45787172
115ILK0.45533795
116PIK3CG0.45328318
117CAMK2B0.45132165
118PRKAA20.45060090
119PAK60.44931663
120PRKACA0.44858373
121EPHA30.43955009
122ERN10.43708097
123PRKCA0.43302805
124PRKCG0.43090351
125DYRK1A0.42943515
126MAP2K10.41270093
127LATS20.40995513
128CCNB10.40648720
129PDPK10.38419528
130JAK10.37704912
131CSNK1A10.35944497
132PRKAA10.35616885
133PRKACG0.34844890
134MINK10.34752649
135SRC0.34479521
136MET0.33420604
137CAMK2G0.33298156
138SGK10.31832024

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.14978525
2Dilated cardiomyopathy_Homo sapiens_hsa054143.03859589
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.93998941
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.73779203
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.41662849
6Cardiac muscle contraction_Homo sapiens_hsa042602.34797926
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.26490322
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.20902021
9Vitamin B6 metabolism_Homo sapiens_hsa007502.06650860
10Linoleic acid metabolism_Homo sapiens_hsa005912.04866778
11Propanoate metabolism_Homo sapiens_hsa006401.85086346
12Fatty acid degradation_Homo sapiens_hsa000711.82492303
13Tryptophan metabolism_Homo sapiens_hsa003801.82182488
14Arginine biosynthesis_Homo sapiens_hsa002201.68811410
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.63572357
16Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.58045757
17Renin secretion_Homo sapiens_hsa049241.52516614
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50039926
19Complement and coagulation cascades_Homo sapiens_hsa046101.49005133
20ECM-receptor interaction_Homo sapiens_hsa045121.48601971
21Retinol metabolism_Homo sapiens_hsa008301.47383025
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.35458784
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34976176
24Pyruvate metabolism_Homo sapiens_hsa006201.28881053
25Fatty acid metabolism_Homo sapiens_hsa012121.27812928
26Viral myocarditis_Homo sapiens_hsa054161.26559529
27Circadian rhythm_Homo sapiens_hsa047101.22785006
28PPAR signaling pathway_Homo sapiens_hsa033201.22737173
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20605408
30Carbon metabolism_Homo sapiens_hsa012001.18184964
31Phenylalanine metabolism_Homo sapiens_hsa003601.15891900
32Circadian entrainment_Homo sapiens_hsa047131.15233173
33Arachidonic acid metabolism_Homo sapiens_hsa005901.12051205
34Oxidative phosphorylation_Homo sapiens_hsa001901.10727016
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.10152551
36Phototransduction_Homo sapiens_hsa047441.09225337
37Nicotine addiction_Homo sapiens_hsa050331.06141737
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.05291021
39Butanoate metabolism_Homo sapiens_hsa006501.05071191
40Taste transduction_Homo sapiens_hsa047421.04841815
41Focal adhesion_Homo sapiens_hsa045101.04164404
42Morphine addiction_Homo sapiens_hsa050321.04137793
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04023413
44Bile secretion_Homo sapiens_hsa049761.03572969
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03323838
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01250338
47Insulin secretion_Homo sapiens_hsa049111.01055493
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99775668
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99470150
50Serotonergic synapse_Homo sapiens_hsa047260.98764776
51Ether lipid metabolism_Homo sapiens_hsa005650.98562889
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97642371
53Collecting duct acid secretion_Homo sapiens_hsa049660.96219682
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.94997043
55Calcium signaling pathway_Homo sapiens_hsa040200.94150503
56Peroxisome_Homo sapiens_hsa041460.93553212
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92865821
58Caffeine metabolism_Homo sapiens_hsa002320.92814024
59Pancreatic secretion_Homo sapiens_hsa049720.92564833
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91555005
61Oxytocin signaling pathway_Homo sapiens_hsa049210.89140363
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87247531
63Alzheimers disease_Homo sapiens_hsa050100.86414640
64Salivary secretion_Homo sapiens_hsa049700.86259891
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85907864
66GABAergic synapse_Homo sapiens_hsa047270.85812966
67ABC transporters_Homo sapiens_hsa020100.85673773
68Parkinsons disease_Homo sapiens_hsa050120.85253011
69Cocaine addiction_Homo sapiens_hsa050300.84557012
70Dopaminergic synapse_Homo sapiens_hsa047280.83744219
71beta-Alanine metabolism_Homo sapiens_hsa004100.82313834
72Starch and sucrose metabolism_Homo sapiens_hsa005000.81692972
73Synaptic vesicle cycle_Homo sapiens_hsa047210.80807417
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80304231
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80063399
76Fatty acid elongation_Homo sapiens_hsa000620.77543738
77Fat digestion and absorption_Homo sapiens_hsa049750.76269626
78Amoebiasis_Homo sapiens_hsa051460.75021095
79Glucagon signaling pathway_Homo sapiens_hsa049220.73618675
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71984983
81cAMP signaling pathway_Homo sapiens_hsa040240.71808603
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71795509
83Mineral absorption_Homo sapiens_hsa049780.71126342
84Tyrosine metabolism_Homo sapiens_hsa003500.67825253
85Gastric acid secretion_Homo sapiens_hsa049710.66278972
86Thyroid hormone synthesis_Homo sapiens_hsa049180.66156122
87Biosynthesis of amino acids_Homo sapiens_hsa012300.66026438
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65538786
89Amphetamine addiction_Homo sapiens_hsa050310.64383685
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64212025
91GnRH signaling pathway_Homo sapiens_hsa049120.64029788
92Long-term depression_Homo sapiens_hsa047300.62604255
93Nitrogen metabolism_Homo sapiens_hsa009100.62515917
94Glutamatergic synapse_Homo sapiens_hsa047240.62384438
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61555832
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61158397
97Chemical carcinogenesis_Homo sapiens_hsa052040.60779116
98Other glycan degradation_Homo sapiens_hsa005110.58611795
99Arginine and proline metabolism_Homo sapiens_hsa003300.58088739
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57571260
101Insulin resistance_Homo sapiens_hsa049310.57197455
102Prion diseases_Homo sapiens_hsa050200.57158623
103Gap junction_Homo sapiens_hsa045400.56845802
104Axon guidance_Homo sapiens_hsa043600.55729796
105Adherens junction_Homo sapiens_hsa045200.52534152
106Dorso-ventral axis formation_Homo sapiens_hsa043200.52335603
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52300025
108Glycerolipid metabolism_Homo sapiens_hsa005610.51389816
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51297532
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.51283688
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.50784245
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50756058
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50006241
114Long-term potentiation_Homo sapiens_hsa047200.49477973
115Protein digestion and absorption_Homo sapiens_hsa049740.49438714
116Olfactory transduction_Homo sapiens_hsa047400.47958037
117Ovarian steroidogenesis_Homo sapiens_hsa049130.46857480
118Cholinergic synapse_Homo sapiens_hsa047250.46777056
119Lysine degradation_Homo sapiens_hsa003100.46650697
120Histidine metabolism_Homo sapiens_hsa003400.45603463
121Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45529369
122Type II diabetes mellitus_Homo sapiens_hsa049300.44346625
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.44328102
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.44294647
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43525367
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40507351
127Estrogen signaling pathway_Homo sapiens_hsa049150.40453528
128Tight junction_Homo sapiens_hsa045300.39616133
129Staphylococcus aureus infection_Homo sapiens_hsa051500.39499608

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