ADAMTSL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)6.70415635
2extracellular matrix assembly (GO:0085029)6.42083004
3protein heterotrimerization (GO:0070208)6.30521124
4sequestering of extracellular ligand from receptor (GO:0035581)6.15457155
5chondrocyte proliferation (GO:0035988)5.91026816
6protein localization to cell surface (GO:0034394)5.71233042
7dermatan sulfate biosynthetic process (GO:0030208)5.60540011
8dermatan sulfate metabolic process (GO:0030205)5.23712375
9cell adhesion mediated by integrin (GO:0033627)5.06438747
10induction of positive chemotaxis (GO:0050930)4.79930264
11peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.75969711
12behavioral response to nicotine (GO:0035095)4.67092424
13keratan sulfate catabolic process (GO:0042340)4.55792869
14metanephric mesenchyme development (GO:0072075)4.48248072
15neuron projection extension involved in neuron projection guidance (GO:1902284)4.40660732
16axon extension involved in axon guidance (GO:0048846)4.40660732
17kidney mesenchyme development (GO:0072074)4.37836590
18extracellular fibril organization (GO:0043206)4.29132000
19tryptophan catabolic process (GO:0006569)4.27691777
20indole-containing compound catabolic process (GO:0042436)4.27691777
21indolalkylamine catabolic process (GO:0046218)4.27691777
22smooth muscle tissue development (GO:0048745)4.23944085
23endodermal cell differentiation (GO:0035987)4.15208818
24kynurenine metabolic process (GO:0070189)4.14234718
25collagen metabolic process (GO:0032963)4.05387348
26regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.98808580
27positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.93818916
28retina vasculature morphogenesis in camera-type eye (GO:0061299)3.92749010
29collagen catabolic process (GO:0030574)3.90467234
30indolalkylamine metabolic process (GO:0006586)3.86259720
31regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.86092201
32positive regulation of developmental pigmentation (GO:0048087)3.83451419
33fibril organization (GO:0097435)3.82048533
34multicellular organismal macromolecule metabolic process (GO:0044259)3.78899168
35bone trabecula formation (GO:0060346)3.77394630
36negative regulation of chondrocyte differentiation (GO:0032331)3.76428333
37regulation of pigment cell differentiation (GO:0050932)3.74559766
38cilium or flagellum-dependent cell motility (GO:0001539)3.73263261
39negative regulation of translation, ncRNA-mediated (GO:0040033)3.72720146
40regulation of translation, ncRNA-mediated (GO:0045974)3.72720146
41negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.72720146
42establishment of protein localization to Golgi (GO:0072600)3.67503509
43omega-hydroxylase P450 pathway (GO:0097267)3.65924237
44interkinetic nuclear migration (GO:0022027)3.65914878
45regulation of hippo signaling (GO:0035330)3.65623010
46epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.64857164
47endothelial cell morphogenesis (GO:0001886)3.64763417
48gonadal mesoderm development (GO:0007506)3.64349518
49multicellular organismal metabolic process (GO:0044236)3.62252197
50detection of light stimulus involved in visual perception (GO:0050908)3.60568098
51detection of light stimulus involved in sensory perception (GO:0050962)3.60568098
52tryptophan metabolic process (GO:0006568)3.60566392
53extracellular negative regulation of signal transduction (GO:1900116)3.58580102
54extracellular regulation of signal transduction (GO:1900115)3.58580102
55multicellular organismal catabolic process (GO:0044243)3.56248357
56skin morphogenesis (GO:0043589)3.55402824
57peptidyl-proline hydroxylation (GO:0019511)3.55195397
58regulation of posttranscriptional gene silencing (GO:0060147)3.54418620
59regulation of gene silencing by miRNA (GO:0060964)3.54418620
60regulation of gene silencing by RNA (GO:0060966)3.54418620
61snRNA transcription (GO:0009301)3.53789081
62plasma membrane repair (GO:0001778)3.53705074
63extracellular matrix disassembly (GO:0022617)3.51088173
64oxidative demethylation (GO:0070989)3.45664307
65craniofacial suture morphogenesis (GO:0097094)3.44847895
66epoxygenase P450 pathway (GO:0019373)3.44516809
67regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.44465612
68mesenchymal-epithelial cell signaling (GO:0060638)3.44346027
69fucose catabolic process (GO:0019317)3.43082503
70L-fucose metabolic process (GO:0042354)3.43082503
71L-fucose catabolic process (GO:0042355)3.43082503
72extracellular matrix organization (GO:0030198)3.42420289
73extracellular structure organization (GO:0043062)3.40920825
74positive regulation of extracellular matrix organization (GO:1903055)3.38944912
75protein targeting to plasma membrane (GO:0072661)3.37473950
76cranial suture morphogenesis (GO:0060363)3.32688559
77protein K48-linked deubiquitination (GO:0071108)3.31885329
78neural tube formation (GO:0001841)3.28344914
79negative regulation of cytosolic calcium ion concentration (GO:0051481)3.24117582
80positive regulation of blood vessel endothelial cell migration (GO:0043536)3.20730791
81gamma-aminobutyric acid transport (GO:0015812)3.20508991
82regulation of tight junction assembly (GO:2000810)3.20482199
83indole-containing compound metabolic process (GO:0042430)3.19596801
84serotonin metabolic process (GO:0042428)3.18462282
85regulation of establishment of cell polarity (GO:2000114)3.17464442
86chondroitin sulfate biosynthetic process (GO:0030206)3.16716731
87basement membrane organization (GO:0071711)3.13639519
88primary amino compound metabolic process (GO:1901160)3.13563622
89negative regulation of cartilage development (GO:0061037)3.13515784
90detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.13201504
91negative regulation of fatty acid transport (GO:2000192)3.13050953
92negative regulation of sodium ion transport (GO:0010766)3.12631400
93negative regulation of systemic arterial blood pressure (GO:0003085)3.12373632
94glomerular basement membrane development (GO:0032836)3.11333230
95monoubiquitinated protein deubiquitination (GO:0035520)3.11325697
96negative regulation of protein localization to cell surface (GO:2000009)3.11256425
97signal peptide processing (GO:0006465)3.11244228
98lymphangiogenesis (GO:0001946)3.10965250
99neuronal action potential (GO:0019228)3.10913778
100cell proliferation involved in kidney development (GO:0072111)3.10520230
101cell migration involved in heart development (GO:0060973)3.08470567
102epithelial cell-cell adhesion (GO:0090136)3.08319125
103negative regulation of stem cell proliferation (GO:2000647)3.07745476
104middle ear morphogenesis (GO:0042474)3.07387485
105endocardial cushion development (GO:0003197)3.04427061
106membrane depolarization during action potential (GO:0086010)3.02183868
107cellular ketone body metabolic process (GO:0046950)3.01078830
108protein retention in ER lumen (GO:0006621)3.00936092
109blood vessel maturation (GO:0001955)3.00843512
110mesodermal cell differentiation (GO:0048333)3.00526246
111wound healing, spreading of epidermal cells (GO:0035313)3.00443866
112insulin-like growth factor receptor signaling pathway (GO:0048009)2.99297313
113maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.99073143
114protein hydroxylation (GO:0018126)2.99060268
115vascular endothelial growth factor signaling pathway (GO:0038084)2.98865513
116membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.97575999
117regulation of establishment or maintenance of cell polarity (GO:0032878)2.96388251
118vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.95986098
119chondrocyte development (GO:0002063)2.95174302
120substrate-dependent cell migration (GO:0006929)2.93527553
121chondroitin sulfate catabolic process (GO:0030207)2.92425588
122sulfation (GO:0051923)2.91175963
123protein K11-linked deubiquitination (GO:0035871)2.90788278
124apoptotic cell clearance (GO:0043277)2.90239519
125notochord development (GO:0030903)2.89251076
126cell-matrix adhesion (GO:0007160)2.89004775
127photoreceptor cell maintenance (GO:0045494)2.87389018
128positive regulation of endothelial cell apoptotic process (GO:2000353)2.87021496
129substrate adhesion-dependent cell spreading (GO:0034446)2.86289556
130reflex (GO:0060004)2.86195121
131endothelial cell proliferation (GO:0001935)2.85621716
132embryonic cranial skeleton morphogenesis (GO:0048701)2.85513095
133lymph vessel development (GO:0001945)2.85093588
134endosome to pigment granule transport (GO:0043485)2.84975381
135endosome to melanosome transport (GO:0035646)2.84975381
136regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.82650087
137cardiovascular system development (GO:0072358)2.81057525
138camera-type eye morphogenesis (GO:0048593)2.80174506
139limb development (GO:0060173)2.78517231
140appendage development (GO:0048736)2.78517231
141flavonoid metabolic process (GO:0009812)2.78470274
142lipid translocation (GO:0034204)2.77612294
143phospholipid translocation (GO:0045332)2.77612294
144response to pheromone (GO:0019236)2.77457169
145interleukin-6-mediated signaling pathway (GO:0070102)2.75078861
146behavioral response to ethanol (GO:0048149)2.74888034
147ketone body metabolic process (GO:1902224)2.74871554
148neural crest cell development (GO:0014032)2.74381094
149G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.73754766
150regulation of sarcomere organization (GO:0060297)2.73701596
151response to fluid shear stress (GO:0034405)2.72973271
152mesonephric tubule development (GO:0072164)2.71922521
153thyroid hormone metabolic process (GO:0042403)2.71740941
154mesenchymal cell proliferation (GO:0010463)2.71428926
155protein polyglutamylation (GO:0018095)2.71352478
156cilium movement (GO:0003341)2.71291402
157regulation of integrin-mediated signaling pathway (GO:2001044)2.70779237
158cell-substrate adhesion (GO:0031589)2.68567644
159mesonephric epithelium development (GO:0072163)2.68520701
160cellular response to vitamin (GO:0071295)2.67715009
161epithelial cilium movement (GO:0003351)2.67484369
162regulation of positive chemotaxis (GO:0050926)2.67305563
163regulation of macrophage cytokine production (GO:0010935)2.66922865
164NAD biosynthetic process (GO:0009435)2.66836296
165positive regulation of positive chemotaxis (GO:0050927)2.66378057
166regulation of superoxide metabolic process (GO:0090322)2.65335881
167glomerular visceral epithelial cell development (GO:0072015)2.64999294
168drug catabolic process (GO:0042737)2.64628058
169axoneme assembly (GO:0035082)2.64435419
170regulation of mesenchymal cell proliferation (GO:0010464)2.62031907
171regulation of action potential (GO:0098900)2.61308520
172protein K63-linked deubiquitination (GO:0070536)2.61120839
173cilium organization (GO:0044782)2.60452011
174transmission of nerve impulse (GO:0019226)2.58470155
175cellular biogenic amine catabolic process (GO:0042402)2.57127634
176amine catabolic process (GO:0009310)2.57127634
177cilium assembly (GO:0042384)2.56544664
178spinal cord motor neuron differentiation (GO:0021522)2.54729626
179ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.54648506
180nonmotile primary cilium assembly (GO:0035058)2.52963883
181cilium morphogenesis (GO:0060271)2.52401839
182negative regulation of mast cell activation (GO:0033004)2.51542903
183cAMP catabolic process (GO:0006198)2.50405649
184synaptic vesicle docking involved in exocytosis (GO:0016081)2.49895872
185protein targeting to vacuole (GO:0006623)2.49307724
186protein targeting to lysosome (GO:0006622)2.49307724
187establishment of protein localization to vacuole (GO:0072666)2.49307724
188retina layer formation (GO:0010842)2.49094675
189regulation of short-term neuronal synaptic plasticity (GO:0048172)2.48684023
190positive regulation of action potential (GO:0045760)2.47128932
191retinal cone cell development (GO:0046549)2.46535218
192kidney morphogenesis (GO:0060993)2.43219518
193histone H3-K9 methylation (GO:0051567)2.41655084
194positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.41253861
195tachykinin receptor signaling pathway (GO:0007217)2.39988341
196pericardium development (GO:0060039)2.38956088
197cellular response to sterol (GO:0036315)2.37492305
198benzene-containing compound metabolic process (GO:0042537)2.37109220
199protein targeting to Golgi (GO:0000042)2.36659222
200histone H3-K4 trimethylation (GO:0080182)2.36087784

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.80381611
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.43896157
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.18391181
4EZH2_22144423_ChIP-Seq_EOC_Human3.95269397
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.16684031
6CJUN_26792858_Chip-Seq_BT549_Human3.01770007
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.92879238
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.88967619
9VDR_22108803_ChIP-Seq_LS180_Human2.87854127
10CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.78041563
11* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.77588056
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.74867203
13ZNF274_21170338_ChIP-Seq_K562_Hela2.71224770
14CLOCK_20551151_ChIP-Seq_293T_Human2.68895519
15NRF2_20460467_ChIP-Seq_MEFs_Mouse2.61467028
16NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.61467028
17RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.52454126
18CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.49853163
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.46617666
20WT1_19549856_ChIP-ChIP_CCG9911_Human2.46268829
21EP300_21415370_ChIP-Seq_HL-1_Mouse2.38726828
22ESR1_21235772_ChIP-Seq_MCF-7_Human2.37316362
23TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.33463546
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.28533933
25GBX2_23144817_ChIP-Seq_PC3_Human2.24360734
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.23556420
27POU3F2_20337985_ChIP-ChIP_501MEL_Human2.15118858
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.13936952
29TAF15_26573619_Chip-Seq_HEK293_Human2.12534356
30RBPJ_22232070_ChIP-Seq_NCS_Mouse2.11765007
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04755153
32IGF1R_20145208_ChIP-Seq_DFB_Human2.04241072
33SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.97039874
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.96210157
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95943673
36TP53_18474530_ChIP-ChIP_U2OS_Human1.93569044
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93567551
38BRD4_25478319_ChIP-Seq_HGPS_Human1.93280906
39P300_19829295_ChIP-Seq_ESCs_Human1.92529122
40STAT3_23295773_ChIP-Seq_U87_Human1.90841492
41NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.83994824
42SMAD4_21799915_ChIP-Seq_A2780_Human1.82070338
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.82055687
44ER_23166858_ChIP-Seq_MCF-7_Human1.80049818
45FUS_26573619_Chip-Seq_HEK293_Human1.78389785
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.77504526
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.76734086
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.76461080
49DROSHA_22980978_ChIP-Seq_HELA_Human1.75836729
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74301302
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74280325
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.74280325
53EWS_26573619_Chip-Seq_HEK293_Human1.73045023
54EZH2_18974828_ChIP-Seq_MESCs_Mouse1.70757265
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.70757265
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.70175600
57TCF4_23295773_ChIP-Seq_U87_Human1.69625991
58SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.68624410
59TP53_16413492_ChIP-PET_HCT116_Human1.65529316
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.63894008
61EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.63036046
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62430580
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.60417641
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.60392827
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.56271592
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55539549
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.55340597
68TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.54799614
69SALL4_18804426_ChIP-ChIP_XEN_Mouse1.52833032
70SMC1_22415368_ChIP-Seq_MEFs_Mouse1.51672409
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51186668
72SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.50293539
73* AR_25329375_ChIP-Seq_VCAP_Human1.49756404
74* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49633376
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.49148456
76REST_21632747_ChIP-Seq_MESCs_Mouse1.48982044
77SOX2_20726797_ChIP-Seq_SW620_Human1.48811915
78GATA2_21666600_ChIP-Seq_HMVEC_Human1.48186250
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47551636
80CBP_20019798_ChIP-Seq_JUKART_Human1.47551636
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46865715
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46754255
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43998572
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42150010
85SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.42025091
86SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.42025091
87SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41646536
88AR_21572438_ChIP-Seq_LNCaP_Human1.39988101
89* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38724133
90* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37746232
91FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35890729
92* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34183836
93HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33834585
94CBX2_27304074_Chip-Seq_ESCs_Mouse1.32860999
95* RUNX2_22187159_ChIP-Seq_PCA_Human1.30237700
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30039437
97EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29163584
98* ARNT_22903824_ChIP-Seq_MCF-7_Human1.29107532
99TCF4_22108803_ChIP-Seq_LS180_Human1.29074175
100SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.29042217
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28746011
102* AHR_22903824_ChIP-Seq_MCF-7_Human1.27833296
103SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27576008
104* PRDM14_20953172_ChIP-Seq_ESCs_Human1.25450929
105CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.24398716
106PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23576724
107BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23360435
108SMAD4_21741376_ChIP-Seq_EPCs_Human1.20415339
109IRF1_19129219_ChIP-ChIP_H3396_Human1.19895905
110SA1_22415368_ChIP-Seq_MEFs_Mouse1.19863155
111MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.19639211
112RNF2_27304074_Chip-Seq_NSC_Mouse1.19350211
113TP53_20018659_ChIP-ChIP_R1E_Mouse1.18760765
114FLI1_21867929_ChIP-Seq_TH2_Mouse1.17904556
115JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17629603
116SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17504540
117GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17153092
118ESR1_20079471_ChIP-ChIP_T-47D_Human1.16437709
119* SOX2_21211035_ChIP-Seq_LN229_Gbm1.16068093
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14708661
121BCAT_22108803_ChIP-Seq_LS180_Human1.13651561
122KDM2B_26808549_Chip-Seq_REH_Human1.13403861
123MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13203630
124UBF1/2_26484160_Chip-Seq_HMECs_Human1.12920781
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12833601
126TBX20_22328084_ChIP-Seq_HEART_Mouse1.12772202
127TBX20_22080862_ChIP-Seq_HEART_Mouse1.12772202
128* PIAS1_25552417_ChIP-Seq_VCAP_Human1.12749465
129EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12742311
130ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.12366299
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11901502
132* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11447546
133EZH2_27294783_Chip-Seq_NPCs_Mouse1.08529802
134SMAD3_21741376_ChIP-Seq_ESCs_Human1.08355657
135BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08052767
136CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07158322
137MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06285686
138TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06220152
139NANOG_18555785_Chip-Seq_ESCs_Mouse1.06032283
140EZH2_27304074_Chip-Seq_ESCs_Mouse1.05718694
141CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05503290
142RNF2_27304074_Chip-Seq_ESCs_Mouse1.05430606
143NFE2_27457419_Chip-Seq_LIVER_Mouse1.05025928
144FOXO3_23340844_ChIP-Seq_DLD1_Human1.04932453
145EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03974573
146TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03470550
147AR_19668381_ChIP-Seq_PC3_Human1.02652837
148SMAD3_21741376_ChIP-Seq_HESCs_Human1.02409330
149SOX2_19829295_ChIP-Seq_ESCs_Human1.02321504
150NANOG_19829295_ChIP-Seq_ESCs_Human1.02321504
151EZH2_27294783_Chip-Seq_ESCs_Mouse1.02309117
152TP53_23651856_ChIP-Seq_MEFs_Mouse1.01952592
153SMC3_22415368_ChIP-Seq_MEFs_Mouse1.01747950
154TP63_23658742_ChIP-Seq_EP156T_Human1.01689823
155TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00581322
156NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99788708
157PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99181173
158NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98174855
159RXR_22108803_ChIP-Seq_LS180_Human0.97775159
160SMAD4_21741376_ChIP-Seq_HESCs_Human0.97479579
161P53_22387025_ChIP-Seq_ESCs_Mouse0.97402404
162* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94868997
163SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93796459
164STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91523863
165OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91231208
166JARID2_20064375_ChIP-Seq_MESCs_Mouse0.90897286
167NFI_21473784_ChIP-Seq_ESCs_Mouse0.90473147
168ELK3_25401928_ChIP-Seq_HUVEC_Human0.90348142
169PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.90244079
170P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90047392
171* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88690846
172RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.87482381
173ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86047591
174JUN_21703547_ChIP-Seq_K562_Human0.85139304
175SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81331248
176NR3C1_23031785_ChIP-Seq_PC12_Mouse0.81257909
177PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.80545061
178ISL1_27105846_Chip-Seq_CPCs_Mouse0.78586683

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.89600907
2MP0005503_abnormal_tendon_morphology5.84231484
3MP0005275_abnormal_skin_tensile5.79795192
4MP0001958_emphysema5.11221514
5MP0003705_abnormal_hypodermis_morpholog4.82818315
6MP0003279_aneurysm4.29195515
7MP0000569_abnormal_digit_pigmentation3.90313703
8MP0009384_cardiac_valve_regurgitation3.29202008
9MP0003195_calcinosis3.16864146
10MP0003646_muscle_fatigue3.05056626
11MP0004272_abnormal_basement_membrane2.76928733
12MP0002295_abnormal_pulmonary_circulatio2.64289422
13MP0005551_abnormal_eye_electrophysiolog2.49452736
14MP0009046_muscle_twitch2.46779932
15MP0008057_abnormal_DNA_replication2.45897017
16MP0003787_abnormal_imprinting2.44761097
17MP0004043_abnormal_pH_regulation2.44216280
18MP0005257_abnormal_intraocular_pressure2.36447931
19MP0008877_abnormal_DNA_methylation2.33199782
20MP0001968_abnormal_touch/_nociception2.28314018
21MP0003136_yellow_coat_color2.18973420
22MP0005508_abnormal_skeleton_morphology2.16536955
23MP0001879_abnormal_lymphatic_vessel2.09892797
24MP0001501_abnormal_sleep_pattern2.00676792
25MP0009745_abnormal_behavioral_response1.98096666
26MP0000427_abnormal_hair_cycle1.95596742
27MP0010030_abnormal_orbit_morphology1.92865499
28MP0002060_abnormal_skin_morphology1.92717039
29MP0010368_abnormal_lymphatic_system1.92415624
30MP0006054_spinal_hemorrhage1.87678703
31MP0002108_abnormal_muscle_morphology1.86283228
32MP0002272_abnormal_nervous_system1.84723283
33MP0006276_abnormal_autonomic_nervous1.83389023
34MP0005623_abnormal_meninges_morphology1.81869885
35MP0004142_abnormal_muscle_tone1.80635749
36MP0003890_abnormal_embryonic-extraembry1.76434312
37MP0001486_abnormal_startle_reflex1.76428841
38MP0002735_abnormal_chemical_nociception1.75127866
39MP0004883_abnormal_blood_vessel1.69623114
40MP0006292_abnormal_olfactory_placode1.68487532
41MP0002736_abnormal_nociception_after1.67127682
42MP0004145_abnormal_muscle_electrophysio1.65289788
43MP0003880_abnormal_central_pattern1.63306684
44MP0005171_absent_coat_pigmentation1.61695465
45MP0005646_abnormal_pituitary_gland1.61149710
46MP0003566_abnormal_cell_adhesion1.59755276
47MP0001542_abnormal_bone_strength1.58683196
48MP0000383_abnormal_hair_follicle1.58174291
49MP0002837_dystrophic_cardiac_calcinosis1.57372679
50MP0002572_abnormal_emotion/affect_behav1.57187864
51MP0004130_abnormal_muscle_cell1.56795323
52MP0008961_abnormal_basal_metabolism1.56580531
53MP0002064_seizures1.55178257
54MP0001485_abnormal_pinna_reflex1.54522759
55MP0003635_abnormal_synaptic_transmissio1.53901847
56MP0003091_abnormal_cell_migration1.52924810
57MP0004924_abnormal_behavior1.52628345
58MP0005386_behavior/neurological_phenoty1.52628345
59MP0005023_abnormal_wound_healing1.51441701
60MP0002638_abnormal_pupillary_reflex1.48909262
61MP0002102_abnormal_ear_morphology1.48298516
62MP0004133_heterotaxia1.47270372
63MP0005253_abnormal_eye_physiology1.43530081
64MP0005645_abnormal_hypothalamus_physiol1.43067820
65MP0009250_abnormal_appendicular_skeleto1.41803596
66MP0004134_abnormal_chest_morphology1.40877412
67MP0002067_abnormal_sensory_capabilities1.40744323
68MP0002557_abnormal_social/conspecific_i1.40643039
69MP0000767_abnormal_smooth_muscle1.40576817
70MP0002876_abnormal_thyroid_physiology1.39811169
71MP0001986_abnormal_taste_sensitivity1.39155856
72MP0001299_abnormal_eye_distance/1.37970410
73MP0008872_abnormal_physiological_respon1.37842862
74MP0000778_abnormal_nervous_system1.37768908
75MP0005174_abnormal_tail_pigmentation1.36945358
76MP0002009_preneoplasia1.36653564
77MP0003385_abnormal_body_wall1.36469827
78MP0002063_abnormal_learning/memory/cond1.36208498
79MP0001970_abnormal_pain_threshold1.35679836
80MP0000631_abnormal_neuroendocrine_gland1.35133859
81MP0002653_abnormal_ependyma_morphology1.33063440
82MP0002733_abnormal_thermal_nociception1.31714714
83MP0002282_abnormal_trachea_morphology1.31278190
84MP0002133_abnormal_respiratory_system1.30792436
85MP0005388_respiratory_system_phenotype1.30792436
86MP0005595_abnormal_vascular_smooth1.26133452
87MP0002933_joint_inflammation1.24301349
88MP0000428_abnormal_craniofacial_morphol1.23632244
89MP0002734_abnormal_mechanical_nocicepti1.20827731
90MP0001243_abnormal_dermal_layer1.20650974
91MP0005423_abnormal_somatic_nervous1.20238763
92MP0001984_abnormal_olfaction1.19443488
93MP0005164_abnormal_response_to1.19395914
94MP0006072_abnormal_retinal_apoptosis1.19053539
95MP0004885_abnormal_endolymph1.17275064
96MP0005377_hearing/vestibular/ear_phenot1.17039452
97MP0003878_abnormal_ear_physiology1.17039452
98MP0005390_skeleton_phenotype1.15711720
99MP0002877_abnormal_melanocyte_morpholog1.14134863
100MP0002896_abnormal_bone_mineralization1.11455052
101MP0002938_white_spotting1.10566112
102MP0000534_abnormal_ureter_morphology1.10553457
103MP0002138_abnormal_hepatobiliary_system1.10194640
104MP0000751_myopathy1.07921843
105MP0005195_abnormal_posterior_eye1.07523063
106MP0000230_abnormal_systemic_arterial1.07276226
107MP0004147_increased_porphyrin_level1.07053259
108MP0000733_abnormal_muscle_development1.05688733
109MP0000749_muscle_degeneration1.04005704
110MP0002184_abnormal_innervation1.03632257
111MP0000163_abnormal_cartilage_morphology1.02689397
112MP0000858_altered_metastatic_potential1.02054537
113MP0002752_abnormal_somatic_nervous1.01378529
114MP0005167_abnormal_blood-brain_barrier1.00189757
115MP0001177_atelectasis1.00161441
116MP0000955_abnormal_spinal_cord0.99266210
117MP0003879_abnormal_hair_cell0.98999051
118MP0002882_abnormal_neuron_morphology0.97691865
119MP0010352_gastrointestinal_tract_polyps0.97397475
120MP0002229_neurodegeneration0.96655287
121MP0005187_abnormal_penis_morphology0.94802993
122MP0001324_abnormal_eye_pigmentation0.94038973
123MP0005197_abnormal_uvea_morphology0.93732673
124MP0000013_abnormal_adipose_tissue0.93600360
125MP0003119_abnormal_digestive_system0.93436498
126MP0003137_abnormal_impulse_conducting0.92734239
127MP0003045_fibrosis0.91611066
128MP0004215_abnormal_myocardial_fiber0.91572662
129MP0004742_abnormal_vestibular_system0.91449575
130MP0003942_abnormal_urinary_system0.90506380
131MP0003633_abnormal_nervous_system0.90445495
132MP0003121_genomic_imprinting0.89700683
133MP0005448_abnormal_energy_balance0.89489890
134MP0005266_abnormal_metabolism0.88348911
135MP0002115_abnormal_skeleton_extremities0.87524033
136MP0000538_abnormal_urinary_bladder0.87139253
137MP0002168_other_aberrant_phenotype0.86486963
138MP0001440_abnormal_grooming_behavior0.85560635
139MP0005670_abnormal_white_adipose0.83527311
140MP0002128_abnormal_blood_circulation0.83014931
141MP0004085_abnormal_heartbeat0.81453442
142MP0002095_abnormal_skin_pigmentation0.81381774
143MP0001963_abnormal_hearing_physiology0.80896664
144MP0004859_abnormal_synaptic_plasticity0.80139409
145MP0000026_abnormal_inner_ear0.78637137
146MP0002932_abnormal_joint_morphology0.78597610
147MP0003724_increased_susceptibility_to0.77980769
148MP0002160_abnormal_reproductive_system0.77765043
149MP0004084_abnormal_cardiac_muscle0.77473740
150MP0001502_abnormal_circadian_rhythm0.77233163
151MP0003698_abnormal_male_reproductive0.76317598
152MP0003283_abnormal_digestive_organ0.76190184
153MP0001614_abnormal_blood_vessel0.76035505
154MP0008775_abnormal_heart_ventricle0.73043613
155MP0002113_abnormal_skeleton_development0.72653553
156MP0003755_abnormal_palate_morphology0.71446520
157MP0003252_abnormal_bile_duct0.71425718
158MP0003115_abnormal_respiratory_system0.71404008
159MP0000762_abnormal_tongue_morphology0.71400308
160MP0006138_congestive_heart_failure0.70402203
161MP0003300_gastrointestinal_ulcer0.69743882
162MP0002249_abnormal_larynx_morphology0.68011680
163MP0010386_abnormal_urinary_bladder0.67729359
164MP0003448_altered_tumor_morphology0.67194626
165MP0002998_abnormal_bone_remodeling0.66742696
166MP0001175_abnormal_lung_morphology0.65907014
167MP0002928_abnormal_bile_duct0.64465235
168MP0005367_renal/urinary_system_phenotyp0.63374411
169MP0000516_abnormal_urinary_system0.63374411
170MP0005076_abnormal_cell_differentiation0.62890612
171MP0000432_abnormal_head_morphology0.62315242
172MP0002925_abnormal_cardiovascular_devel0.62145603
173MP0000049_abnormal_middle_ear0.61079695
174MP0000249_abnormal_blood_vessel0.60663650
175MP0009053_abnormal_anal_canal0.59731130
176MP0003950_abnormal_plasma_membrane0.59578802
177MP0001533_abnormal_skeleton_physiology0.59466079
178MP0005330_cardiomyopathy0.59232154
179MP0005620_abnormal_muscle_contractility0.59199237
180MP0002233_abnormal_nose_morphology0.58284710
181MP0003935_abnormal_craniofacial_develop0.56904829
182MP0005193_abnormal_anterior_eye0.54058945
183MP0001915_intracranial_hemorrhage0.53942619
184MP0000759_abnormal_skeletal_muscle0.53318973
185MP0005369_muscle_phenotype0.53285158
186MP0002166_altered_tumor_susceptibility0.51574892
187MP0003937_abnormal_limbs/digits/tail_de0.51155983
188MP0001346_abnormal_lacrimal_gland0.51067279
189MP0002116_abnormal_craniofacial_bone0.51016962
190MP0003795_abnormal_bone_structure0.50084248
191MP0004087_abnormal_muscle_fiber0.49999990

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.92177904
2Aortic aneurysm (HP:0004942)7.74276751
3Premature rupture of membranes (HP:0001788)7.46122679
4Vascular tortuosity (HP:0004948)6.47118494
5Bladder diverticulum (HP:0000015)5.26602829
6Dilatation of the ascending aorta (HP:0005111)5.12300478
7Wormian bones (HP:0002645)4.84965280
8Aortic dissection (HP:0002647)4.83445581
9Genetic anticipation (HP:0003743)4.78083759
10Hyperventilation (HP:0002883)4.75411260
11Pancreatic cysts (HP:0001737)4.68572938
12Shallow orbits (HP:0000586)4.39343602
13Ankle contracture (HP:0006466)4.34039295
14Pancreatic fibrosis (HP:0100732)4.22889222
15Bowel diverticulosis (HP:0005222)4.16630433
16Soft skin (HP:0000977)4.16519823
17Broad metatarsal (HP:0001783)4.04776706
18Protruding tongue (HP:0010808)3.94708188
19Abnormality of midbrain morphology (HP:0002418)3.90312449
20Molar tooth sign on MRI (HP:0002419)3.90312449
21True hermaphroditism (HP:0010459)3.89572292
22Abnormality of dentin (HP:0010299)3.89325950
23Mitral regurgitation (HP:0001653)3.87282050
24Progressive cerebellar ataxia (HP:0002073)3.86477949
25Premature skin wrinkling (HP:0100678)3.85603875
26Cerebral aneurysm (HP:0004944)3.76588229
27Spinal rigidity (HP:0003306)3.73141239
28Nephronophthisis (HP:0000090)3.68043796
29Peritonitis (HP:0002586)3.60162010
30Congenital stationary night blindness (HP:0007642)3.58890954
31Cervical subluxation (HP:0003308)3.57010788
32Gaze-evoked nystagmus (HP:0000640)3.50444635
33Atrophic scars (HP:0001075)3.44420819
34Abnormality of the renal medulla (HP:0100957)3.40314603
35Vertebral compression fractures (HP:0002953)3.35366316
36Fragile skin (HP:0001030)3.33965449
37Biconcave vertebral bodies (HP:0004586)3.32162936
38Clumsiness (HP:0002312)3.29909679
39Follicular hyperkeratosis (HP:0007502)3.29308257
40Chronic hepatic failure (HP:0100626)3.28552744
41Abnormality of the renal cortex (HP:0011035)3.27436286
42Aplasia/Hypoplasia of the tibia (HP:0005772)3.23607230
43Cystic liver disease (HP:0006706)3.19374111
44Blue sclerae (HP:0000592)3.12916050
45Aortic valve stenosis (HP:0001650)3.12230398
46Aneurysm (HP:0002617)3.11837279
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.11600781
48Tubular atrophy (HP:0000092)3.10512492
49Redundant skin (HP:0001582)3.07725776
50Type 1 muscle fiber predominance (HP:0003803)3.01634310
51Medial flaring of the eyebrow (HP:0010747)2.97883706
52Neonatal short-limb short stature (HP:0008921)2.96291940
53Increased connective tissue (HP:0009025)2.93515159
54Genu recurvatum (HP:0002816)2.93023716
55Spondylolisthesis (HP:0003302)2.91785492
56Overgrowth (HP:0001548)2.90818466
57Short nail (HP:0001799)2.90705577
58Broad-based gait (HP:0002136)2.89385811
59Attenuation of retinal blood vessels (HP:0007843)2.87364293
60Pulmonary artery stenosis (HP:0004415)2.84971791
61Mitral valve prolapse (HP:0001634)2.81859872
62Abnormal delivery (HP:0001787)2.75045302
63Febrile seizures (HP:0002373)2.72937728
64Fair hair (HP:0002286)2.70987830
65Wrist flexion contracture (HP:0001239)2.69782350
66Gait imbalance (HP:0002141)2.69027443
67Thin bony cortex (HP:0002753)2.64550304
68Patellar aplasia (HP:0006443)2.64191188
69Inability to walk (HP:0002540)2.62897593
70Osteolytic defects of the hand bones (HP:0009699)2.60509986
71Osteolytic defects of the phalanges of the hand (HP:0009771)2.60509986
72Hypoplastic ischia (HP:0003175)2.57631764
73Spinal cord lesions (HP:0100561)2.56152529
74Syringomyelia (HP:0003396)2.56152529
75Elbow flexion contracture (HP:0002987)2.56072861
76Arterial tortuosity (HP:0005116)2.53817782
77Joint laxity (HP:0001388)2.52270994
78Congenital primary aphakia (HP:0007707)2.51677691
79Hyperextensible skin (HP:0000974)2.49371275
80Decreased circulating renin level (HP:0003351)2.46728768
81Bony spicule pigmentary retinopathy (HP:0007737)2.44948893
82Abnormality of the anterior chamber (HP:0000593)2.43294693
83Increased neuronal autofluorescent lipopigment (HP:0002074)2.42963265
84Type II lissencephaly (HP:0007260)2.42764162
85Broad ribs (HP:0000885)2.42171856
86Aplasia/Hypoplasia of the patella (HP:0006498)2.42087657
87Aplasia/Hypoplasia of the tongue (HP:0010295)2.41961318
88Increased variability in muscle fiber diameter (HP:0003557)2.40971913
89Round ear (HP:0100830)2.40708926
90Abnormality of the ischium (HP:0003174)2.38594986
91Congenital hepatic fibrosis (HP:0002612)2.37576218
92Polydipsia (HP:0001959)2.35662981
93Abnormal drinking behavior (HP:0030082)2.35662981
94Abolished electroretinogram (ERG) (HP:0000550)2.33413975
95Focal seizures (HP:0007359)2.29206905
96Genital tract atresia (HP:0001827)2.28893785
97Slender build (HP:0001533)2.28395349
98Generalized hypopigmentation of hair (HP:0011358)2.27361417
99Absent speech (HP:0001344)2.27255502
100Large for gestational age (HP:0001520)2.27185078
101Nephrogenic diabetes insipidus (HP:0009806)2.27071639
102Absent/shortened dynein arms (HP:0200106)2.26825340
103Dynein arm defect of respiratory motile cilia (HP:0012255)2.26825340
104Birth length less than 3rd percentile (HP:0003561)2.25173070
105Spinal cord compression (HP:0002176)2.24775599
106Poor coordination (HP:0002370)2.24376966
107Vaginal atresia (HP:0000148)2.23205425
108Mitral stenosis (HP:0001718)2.22607018
109Sclerocornea (HP:0000647)2.20290291
110Atelectasis (HP:0100750)2.17586172
111Furrowed tongue (HP:0000221)2.16221893
112Scapular winging (HP:0003691)2.16199983
113Mildly elevated creatine phosphokinase (HP:0008180)2.15625286
114Knee flexion contracture (HP:0006380)2.15488861
115Lissencephaly (HP:0001339)2.15477223
116Asymmetry of the thorax (HP:0001555)2.14298358
117Abnormality of the acetabulum (HP:0003170)2.12590759
118Drooling (HP:0002307)2.11275535
119Abnormality of skeletal muscle fiber size (HP:0012084)2.10529737
120Dialeptic seizures (HP:0011146)2.09966910
121Abnormality of alanine metabolism (HP:0010916)2.09727253
122Hyperalaninemia (HP:0003348)2.09727253
123Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.09727253
124Emphysema (HP:0002097)2.08895990
125Aortic regurgitation (HP:0001659)2.07774641
126Progressive inability to walk (HP:0002505)2.07484865
127Anencephaly (HP:0002323)2.06838441
128Widely spaced teeth (HP:0000687)2.05556507
129Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.05512102
130Buphthalmos (HP:0000557)2.05056700
131Cerebellar dysplasia (HP:0007033)2.04287213
132Preaxial foot polydactyly (HP:0001841)2.03500546
133Ectopia lentis (HP:0001083)2.02325947
134Congenital sensorineural hearing impairment (HP:0008527)1.99481745
135Increased corneal curvature (HP:0100692)1.98504363
136Keratoconus (HP:0000563)1.98504363
137Joint stiffness (HP:0001387)1.98430245
138Nonimmune hydrops fetalis (HP:0001790)1.98389243
139Postaxial foot polydactyly (HP:0001830)1.98099994
140Beaking of vertebral bodies (HP:0004568)1.97928077
141Venous abnormality (HP:0002624)1.97794616
142Wide anterior fontanel (HP:0000260)1.97164359
143Tibial bowing (HP:0002982)1.96959659
144Infantile muscular hypotonia (HP:0008947)1.96450925
145Short foot (HP:0001773)1.94842111
146Oligodactyly (hands) (HP:0001180)1.90881664
147Abnormal rod and cone electroretinograms (HP:0008323)1.90590002
148Bell-shaped thorax (HP:0001591)1.90542170
149Camptodactyly of toe (HP:0001836)1.90143792
150Coxa vara (HP:0002812)1.89803998
151Inguinal hernia (HP:0000023)1.89510772
152Hypoplasia of the iris (HP:0007676)1.89114871
153Hypoplastic labia majora (HP:0000059)1.88648134
154Broad face (HP:0000283)1.87804060
155Excessive salivation (HP:0003781)1.87563874
156Decreased central vision (HP:0007663)1.86208626
157Chorioretinal atrophy (HP:0000533)1.85440617
158Renal cortical cysts (HP:0000803)1.85303486
159Preaxial hand polydactyly (HP:0001177)1.85173482
160Male pseudohermaphroditism (HP:0000037)1.85091883
161Bulbous nose (HP:0000414)1.84655953
162Abnormal ciliary motility (HP:0012262)1.84347877
163Arachnodactyly (HP:0001166)1.83216977
164Osteoarthritis (HP:0002758)1.82984289
165Macroglossia (HP:0000158)1.80990962
166Epileptic encephalopathy (HP:0200134)1.80624477
167Highly arched eyebrow (HP:0002553)1.78874850
168Protruding ear (HP:0000411)1.78658362
169Venous insufficiency (HP:0005293)1.78643682
170Polyuria (HP:0000103)1.78409901
171Abnormality of the labia majora (HP:0012881)1.77917958
172Distal lower limb amyotrophy (HP:0008944)1.77629455
173Absence seizures (HP:0002121)1.76587355
174Focal motor seizures (HP:0011153)1.76504540
175Broad long bones (HP:0005622)1.75862165
176Femoral bowing (HP:0002980)1.75413272
177Small hand (HP:0200055)1.75387962
178Short hallux (HP:0010109)1.75216763
179Stomach cancer (HP:0012126)1.73622388
180Thyroid-stimulating hormone excess (HP:0002925)1.73171303
181Bile duct proliferation (HP:0001408)1.71914106
182Abnormal biliary tract physiology (HP:0012439)1.71914106
183Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.71634935
184Full cheeks (HP:0000293)1.71558580
185Decreased skull ossification (HP:0004331)1.71231946
186Deviation of the hallux (HP:0010051)1.70917361
187Abnormal respiratory motile cilium morphology (HP:0005938)1.70790034
188Abnormal respiratory epithelium morphology (HP:0012253)1.70790034
189Congenital, generalized hypertrichosis (HP:0004540)1.69888397
190Congenital glaucoma (HP:0001087)1.69828119
191Platyspondyly (HP:0000926)1.69552594
192Osteopenia (HP:0000938)1.69135370
193Ulnar bowing (HP:0003031)1.68705274
194Increased density of long bones (HP:0006392)1.68458955
195Decreased electroretinogram (ERG) amplitude (HP:0000654)1.68363048
196Aplasia involving bones of the upper limbs (HP:0009823)1.67967864
197Aplasia of the phalanges of the hand (HP:0009802)1.67967864
198Aplasia involving bones of the extremities (HP:0009825)1.67967864
199Atonic seizures (HP:0010819)1.66392178
200Tachypnea (HP:0002789)1.65918820

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.27232252
2TTN4.37862015
3PDGFRA4.00459221
4EPHA33.85777189
5ACVR1B3.61609561
6TRIB33.51836553
7ERBB33.41742454
8BMPR1B3.36003445
9TRPM73.10673337
10PKN22.54695524
11CASK2.41664350
12ADRBK22.34202249
13ZAK2.32852894
14PLK22.25269234
15LATS12.21958266
16FRK2.21493717
17EPHB22.17905815
18PAK32.09946137
19LATS22.05582281
20AKT31.99641095
21SIK11.98248833
22MYLK1.96752622
23PAK21.82158485
24GRK11.81540990
25NTRK31.72805910
26WNK31.71163735
27TAOK31.69695701
28ROCK11.66412769
29INSRR1.66221574
30PDGFRB1.65229360
31MAPK131.64422107
32MAP3K41.57696615
33WNK41.57613474
34CAMK1G1.54808569
35MKNK21.50135902
36PIK3CA1.45739468
37TESK11.44816489
38DMPK1.42147910
39ILK1.40651146
40LIMK11.38655892
41FGFR21.38258120
42MARK11.34266700
43OXSR11.31906649
44TNIK1.30294405
45PINK11.30263712
46FER1.29653227
47DAPK21.18933941
48MAP4K21.17155624
49STK391.15929840
50LRRK21.15874958
51NME21.12570408
52PNCK1.09954880
53SGK21.08872262
54BMX1.05418583
55NTRK21.02568955
56SIK21.02158036
57MET1.02034255
58ROCK21.01618768
59MAP2K11.00034378
60MOS0.97804515
61PTK20.91865877
62NEK90.91012982
63KIT0.90410446
64TLK10.89426728
65MAP3K70.87904477
66PAK60.87675602
67PRKCH0.87178084
68CAMKK20.87160859
69MAPKAPK50.86107652
70CAMK10.83309826
71TEC0.82691243
72RIPK10.81967434
73PAK40.81638982
74PRKCG0.81180863
75NUAK10.79793862
76NTRK10.77958523
77MAPK150.77842743
78PTK60.77387393
79SGK4940.77161644
80SGK2230.77161644
81ERBB40.76346990
82EEF2K0.75982399
83PRKAA20.73643693
84OBSCN0.72977214
85TIE10.70341170
86STK30.70324063
87RPS6KA40.69157535
88CHUK0.68815640
89JAK10.68805642
90LMTK20.67536543
91STK380.65921659
92INSR0.65877967
93BMPR20.64917511
94NLK0.64646105
95ADRBK10.63907959
96MAP2K70.63387864
97TGFBR10.63365524
98TGFBR20.62200890
99ERN10.62129010
100PKN10.61722293
101ABL20.60950470
102MINK10.60840440
103MAP2K60.60593029
104PTK2B0.59730161
105STK38L0.59667626
106STK110.58827033
107PRKAA10.58636274
108CAMKK10.58256998
109CAMK40.57614836
110TNK20.57496445
111CAMK2A0.57005521
112PRKCE0.55211708
113PIK3CG0.55077766
114PRKD10.54040380
115MTOR0.53267615
116PRKG20.52441561
117TXK0.51783293
118CDC42BPA0.51760812
119MARK20.50881832
120RPS6KA60.49330596
121JAK30.49114995
122FGFR30.48888931
123GRK50.48879893
124FGFR10.48608896
125EPHA40.47701506
126SGK10.47239130
127PLK30.46208556
128MUSK0.46172164
129RET0.45164086
130DAPK30.44662961
131TYRO30.44255594
132IRAK10.43027405
133CDK60.42342495
134PIM20.40952254
135PRKACA0.40442200
136SGK30.38857951
137NEK20.38450158
138BRSK20.38219753
139PRKCZ0.37944612
140IGF1R0.37771194
141MAP2K40.37268856
142SRC0.36619161
143MELK0.36272538
144CSNK1D0.35799722
145PDK40.35544369
146PDK30.35544369
147PRPF4B0.35230771
148RPS6KA30.35041660
149PLK40.35009410
150CDK180.34480365
151CDK150.34009937
152PAK10.33942750
153DYRK1A0.33494177
154PHKG10.33487862
155PHKG20.33487862
156DYRK20.33364433
157GRK70.33009555
158CSNK1A1L0.32196937
159PRKD20.31490229
160IKBKB0.30949115
161MKNK10.30688912
162CSNK1A10.30039439
163PRKD30.30031577
164CAMK1D0.29694109
165CDK140.29307899
166SCYL20.28905807
167WNK10.28843651
168PDK20.25868753
169PRKG10.24952647
170RPS6KA20.24814954
171CAMK2D0.24331981
172CDK11A0.23345490
173MAPKAPK30.21101513
174PRKACB0.20079249
175ERBB20.20039355

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.02681842
2Focal adhesion_Homo sapiens_hsa045103.36000101
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.98980075
4Nicotine addiction_Homo sapiens_hsa050332.93505300
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.82322492
6Linoleic acid metabolism_Homo sapiens_hsa005912.71815522
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.63658192
8Phototransduction_Homo sapiens_hsa047442.63641936
9AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.62555421
10Dilated cardiomyopathy_Homo sapiens_hsa054142.59017745
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.58747292
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.43938998
13Protein digestion and absorption_Homo sapiens_hsa049742.30580498
14TGF-beta signaling pathway_Homo sapiens_hsa043502.29177830
15Proteoglycans in cancer_Homo sapiens_hsa052052.27060193
16Malaria_Homo sapiens_hsa051442.19764830
17Nitrogen metabolism_Homo sapiens_hsa009102.17086451
18ABC transporters_Homo sapiens_hsa020102.16004135
19Butanoate metabolism_Homo sapiens_hsa006502.13084947
20Amoebiasis_Homo sapiens_hsa051462.07892546
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.05938929
22Adherens junction_Homo sapiens_hsa045202.05861579
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.03745364
24Taste transduction_Homo sapiens_hsa047421.97914644
25Morphine addiction_Homo sapiens_hsa050321.89304884
26Tryptophan metabolism_Homo sapiens_hsa003801.88035210
27Ether lipid metabolism_Homo sapiens_hsa005651.80188660
28Circadian entrainment_Homo sapiens_hsa047131.74404343
29Glutamatergic synapse_Homo sapiens_hsa047241.72948114
30Olfactory transduction_Homo sapiens_hsa047401.72720328
31PI3K-Akt signaling pathway_Homo sapiens_hsa041511.72445070
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.69729525
33Regulation of actin cytoskeleton_Homo sapiens_hsa048101.65517621
34Melanoma_Homo sapiens_hsa052181.64814457
35Hippo signaling pathway_Homo sapiens_hsa043901.63198309
36Insulin secretion_Homo sapiens_hsa049111.60143551
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.59195834
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.56802294
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.55053856
40Dorso-ventral axis formation_Homo sapiens_hsa043201.48866210
41Viral myocarditis_Homo sapiens_hsa054161.48464710
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.46067972
43MicroRNAs in cancer_Homo sapiens_hsa052061.45686986
44GABAergic synapse_Homo sapiens_hsa047271.45630524
45Serotonergic synapse_Homo sapiens_hsa047261.45295693
46Histidine metabolism_Homo sapiens_hsa003401.38294678
47Tight junction_Homo sapiens_hsa045301.37355632
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37072408
49Calcium signaling pathway_Homo sapiens_hsa040201.36334666
50Primary bile acid biosynthesis_Homo sapiens_hsa001201.36293182
51Rap1 signaling pathway_Homo sapiens_hsa040151.36160909
52Platelet activation_Homo sapiens_hsa046111.34658930
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33782326
54Lysine degradation_Homo sapiens_hsa003101.32829840
55Selenocompound metabolism_Homo sapiens_hsa004501.30837487
56Salivary secretion_Homo sapiens_hsa049701.30601661
57Basal cell carcinoma_Homo sapiens_hsa052171.30255839
58Small cell lung cancer_Homo sapiens_hsa052221.29968476
59Axon guidance_Homo sapiens_hsa043601.27815163
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.26206389
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26031483
62Caffeine metabolism_Homo sapiens_hsa002321.20139469
63Homologous recombination_Homo sapiens_hsa034401.14127605
64Glycerolipid metabolism_Homo sapiens_hsa005611.13977107
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.13051204
66Retinol metabolism_Homo sapiens_hsa008301.12327872
67Chronic myeloid leukemia_Homo sapiens_hsa052201.12260837
68Thyroid hormone synthesis_Homo sapiens_hsa049181.12006067
69Maturity onset diabetes of the young_Homo sapiens_hsa049501.10626519
70Glioma_Homo sapiens_hsa052141.09251465
71Pathways in cancer_Homo sapiens_hsa052001.07586763
72Fanconi anemia pathway_Homo sapiens_hsa034601.06168047
73Prostate cancer_Homo sapiens_hsa052151.05059197
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04771765
75Long-term depression_Homo sapiens_hsa047301.04476353
76Gastric acid secretion_Homo sapiens_hsa049711.04449572
77Cholinergic synapse_Homo sapiens_hsa047251.03808297
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.00231319
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00221928
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97315651
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97289509
82Bladder cancer_Homo sapiens_hsa052190.97117890
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96855461
84cAMP signaling pathway_Homo sapiens_hsa040240.95267707
85Dopaminergic synapse_Homo sapiens_hsa047280.95230890
86Steroid biosynthesis_Homo sapiens_hsa001000.94503357
87N-Glycan biosynthesis_Homo sapiens_hsa005100.91841773
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91108991
89beta-Alanine metabolism_Homo sapiens_hsa004100.90753132
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.87967458
91Salmonella infection_Homo sapiens_hsa051320.87583803
92Phagosome_Homo sapiens_hsa041450.86424428
93Ras signaling pathway_Homo sapiens_hsa040140.85679026
94Pancreatic cancer_Homo sapiens_hsa052120.84255385
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84007558
96TNF signaling pathway_Homo sapiens_hsa046680.83510169
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82462383
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81175392
99Wnt signaling pathway_Homo sapiens_hsa043100.80908104
100Circadian rhythm_Homo sapiens_hsa047100.80855283
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.78357688
102Renin secretion_Homo sapiens_hsa049240.77936545
103Gap junction_Homo sapiens_hsa045400.76194001
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75953707
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75497957
106Pancreatic secretion_Homo sapiens_hsa049720.74955052
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.73477760
108Fatty acid biosynthesis_Homo sapiens_hsa000610.73422580
109Hedgehog signaling pathway_Homo sapiens_hsa043400.73259482
110Sulfur metabolism_Homo sapiens_hsa009200.72350946
111Chemical carcinogenesis_Homo sapiens_hsa052040.71955570
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70875979
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70572524
114Shigellosis_Homo sapiens_hsa051310.70219501
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70213923
116Glutathione metabolism_Homo sapiens_hsa004800.70168225
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.70101321
118Bile secretion_Homo sapiens_hsa049760.69431938
119HTLV-I infection_Homo sapiens_hsa051660.68960893
120Propanoate metabolism_Homo sapiens_hsa006400.68542615
121Endometrial cancer_Homo sapiens_hsa052130.66774914
122Melanogenesis_Homo sapiens_hsa049160.65699691
123Amphetamine addiction_Homo sapiens_hsa050310.65111992
124Arachidonic acid metabolism_Homo sapiens_hsa005900.64954532
125Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64210963
126Basal transcription factors_Homo sapiens_hsa030220.64071683
127Type II diabetes mellitus_Homo sapiens_hsa049300.63667450
128MAPK signaling pathway_Homo sapiens_hsa040100.61218761
129Ovarian steroidogenesis_Homo sapiens_hsa049130.58852105
130Toxoplasmosis_Homo sapiens_hsa051450.58212957
131Rheumatoid arthritis_Homo sapiens_hsa053230.57929628
132Colorectal cancer_Homo sapiens_hsa052100.56933130
133Regulation of autophagy_Homo sapiens_hsa041400.56823205
134Renin-angiotensin system_Homo sapiens_hsa046140.55146904
135cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54772032
136HIF-1 signaling pathway_Homo sapiens_hsa040660.54099575
137Peroxisome_Homo sapiens_hsa041460.52304349
138Phospholipase D signaling pathway_Homo sapiens_hsa040720.52073028
139Apoptosis_Homo sapiens_hsa042100.50935512
140Renal cell carcinoma_Homo sapiens_hsa052110.50779287
141p53 signaling pathway_Homo sapiens_hsa041150.50587854
142Starch and sucrose metabolism_Homo sapiens_hsa005000.49462344
143Cardiac muscle contraction_Homo sapiens_hsa042600.47690207
144FoxO signaling pathway_Homo sapiens_hsa040680.47235321
145Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47049101
146Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46142869
147Prion diseases_Homo sapiens_hsa050200.46018830
148Vibrio cholerae infection_Homo sapiens_hsa051100.45585801
149Hepatitis B_Homo sapiens_hsa051610.44689695
150Endocytosis_Homo sapiens_hsa041440.43926561
151Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43802856
152Neurotrophin signaling pathway_Homo sapiens_hsa047220.43611977
153Galactose metabolism_Homo sapiens_hsa000520.42881167
154Estrogen signaling pathway_Homo sapiens_hsa049150.42658208
155Fat digestion and absorption_Homo sapiens_hsa049750.42257291
156Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41403248
157Mineral absorption_Homo sapiens_hsa049780.41255631
158Oxytocin signaling pathway_Homo sapiens_hsa049210.41061051
159Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40978808
160Glycosaminoglycan degradation_Homo sapiens_hsa005310.37505179
161Sphingolipid metabolism_Homo sapiens_hsa006000.36048106
162Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35182133
163Notch signaling pathway_Homo sapiens_hsa043300.34836150
164Leishmaniasis_Homo sapiens_hsa051400.33969726
165Protein export_Homo sapiens_hsa030600.33780063
166ErbB signaling pathway_Homo sapiens_hsa040120.32165545
167African trypanosomiasis_Homo sapiens_hsa051430.32128531
168Cocaine addiction_Homo sapiens_hsa050300.31984978
169Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31870510
170Complement and coagulation cascades_Homo sapiens_hsa046100.31192946
171Fatty acid degradation_Homo sapiens_hsa000710.30944927
172Lysosome_Homo sapiens_hsa041420.30134912
173Insulin resistance_Homo sapiens_hsa049310.29465424

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