ADAMTSL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-like gene family and encodes a protein with seven thrombospondin type 1 repeats. The thrombospondin type 1 repeat domain is found in many proteins with diverse biological functions including cellular adhesion, angiogenesis, and patterning of the developing nervous system. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)8.05853828
2axon ensheathment in central nervous system (GO:0032291)8.05853828
3negative regulation of erythrocyte differentiation (GO:0045647)5.14807364
4positive regulation of gamma-delta T cell activation (GO:0046645)5.09654652
5negative regulation of protein localization to cell surface (GO:2000009)4.91088894
6response to peptidoglycan (GO:0032494)4.65880586
7cellular extravasation (GO:0045123)4.61954100
8ensheathment of neurons (GO:0007272)4.32507952
9axon ensheathment (GO:0008366)4.32507952
10positive regulation by symbiont of host defense response (GO:0052509)4.30821608
11modulation by symbiont of host defense response (GO:0052031)4.30821608
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.30821608
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.30821608
14positive regulation by organism of defense response of other organism involved in symbiotic interact4.30821608
15modulation by symbiont of host immune response (GO:0052553)4.30821608
16myelination (GO:0042552)4.30266822
17neutrophil activation involved in immune response (GO:0002283)4.25477577
18regulation of skeletal muscle contraction (GO:0014819)4.24732069
19fatty acid elongation (GO:0030497)4.21663092
20detection of molecule of bacterial origin (GO:0032490)4.21365929
21mannose metabolic process (GO:0006013)4.17328043
22creatine metabolic process (GO:0006600)4.17154978
23sarcomere organization (GO:0045214)4.11554870
24long-chain fatty acid biosynthetic process (GO:0042759)4.03827725
25myofibril assembly (GO:0030239)3.84748893
26myelin maintenance (GO:0043217)3.81463679
27macrophage activation involved in immune response (GO:0002281)3.80678223
28regulation of gamma-delta T cell activation (GO:0046643)3.76792935
29actin-myosin filament sliding (GO:0033275)3.73216698
30muscle filament sliding (GO:0030049)3.73216698
31import into cell (GO:0098657)3.57707771
32regulation of mast cell degranulation (GO:0043304)3.55737925
33detection of external biotic stimulus (GO:0098581)3.55169926
34germinal center formation (GO:0002467)3.54790695
35detection of other organism (GO:0098543)3.54785508
36response to muramyl dipeptide (GO:0032495)3.47475966
37regulation of gamma-delta T cell differentiation (GO:0045586)3.47159208
38JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.46544754
39cardiac myofibril assembly (GO:0055003)3.45756148
40negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.40131808
41actin-mediated cell contraction (GO:0070252)3.38248303
42photoreceptor cell differentiation (GO:0046530)3.38086265
43eye photoreceptor cell differentiation (GO:0001754)3.38086265
44positive regulation of cellular amide metabolic process (GO:0034250)3.31663890
45regulation of relaxation of muscle (GO:1901077)3.29256401
46membrane tubulation (GO:0097320)3.29216671
47negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.27176934
48iron ion import (GO:0097286)3.26986487
49detection of bacterium (GO:0016045)3.26416010
50regulation of mast cell activation involved in immune response (GO:0033006)3.25719394
51regulation of T-helper 2 cell differentiation (GO:0045628)3.24965445
52regulation of myeloid leukocyte mediated immunity (GO:0002886)3.24591879
53lipopolysaccharide-mediated signaling pathway (GO:0031663)3.23560089
54regulation of actin filament-based movement (GO:1903115)3.22631901
55positive regulation of B cell differentiation (GO:0045579)3.21484410
56response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.15374605
57plasma membrane repair (GO:0001778)3.15111660
58virion attachment to host cell (GO:0019062)3.13670185
59adhesion of symbiont to host cell (GO:0044650)3.13670185
60astrocyte development (GO:0014002)3.12686411
61detection of biotic stimulus (GO:0009595)3.11139416
62negative regulation of interleukin-12 production (GO:0032695)3.10290389
63myelination in peripheral nervous system (GO:0022011)3.08464523
64peripheral nervous system axon ensheathment (GO:0032292)3.08464523
65sarcoplasmic reticulum calcium ion transport (GO:0070296)3.08160221
66regulation of leukocyte degranulation (GO:0043300)3.07161102
67limb bud formation (GO:0060174)3.06287423
68regulation of interferon-beta biosynthetic process (GO:0045357)3.06100769
69positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.06048664
70negative regulation of cell killing (GO:0031342)3.05715654
71negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.05715654
72positive regulation of action potential (GO:0045760)3.05230132
73positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.99727782
74pinocytosis (GO:0006907)2.96725779
75regulation of histone H3-K27 methylation (GO:0061085)2.96212941
76regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.95401810
77L-amino acid import (GO:0043092)2.94822414
78hemidesmosome assembly (GO:0031581)2.94265634
79adult heart development (GO:0007512)2.93889854
80regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.91835348
81actomyosin structure organization (GO:0031032)2.91582272
82membrane raft organization (GO:0031579)2.90977806
83regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.89716472
84positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.89590815
85cellular response to thyroid hormone stimulus (GO:0097067)2.86708580
86regulation of striated muscle contraction (GO:0006942)2.84041160
87positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.83697190
88leukocyte migration involved in inflammatory response (GO:0002523)2.83686544
89cardiac muscle tissue morphogenesis (GO:0055008)2.83664912
90macrophage activation (GO:0042116)2.82312258
91ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.82158036
92renal filtration (GO:0097205)2.82145879
93neuron remodeling (GO:0016322)2.81981959
94cellular response to epinephrine stimulus (GO:0071872)2.81844972
95T-helper 1 type immune response (GO:0042088)2.79641535
96positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.79567629
97definitive hemopoiesis (GO:0060216)2.78876378
98retina vasculature morphogenesis in camera-type eye (GO:0061299)2.78532130
99oligodendrocyte differentiation (GO:0048709)2.78531673
100glomerular filtration (GO:0003094)2.74800026
101immunoglobulin mediated immune response (GO:0016064)2.74101849
102response to thyroid hormone (GO:0097066)2.72023396
103extracellular matrix assembly (GO:0085029)2.70949700
104response to laminar fluid shear stress (GO:0034616)2.70625219
105negative regulation of potassium ion transmembrane transport (GO:1901380)2.70420690
106myeloid cell activation involved in immune response (GO:0002275)2.70083493
107regulation of mast cell activation (GO:0033003)2.69543853
108peptidyl-tyrosine autophosphorylation (GO:0038083)2.67482973
109regulation of cell communication by electrical coupling (GO:0010649)2.67239259
110response to redox state (GO:0051775)2.66849123
111response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.66095799
112response to host immune response (GO:0052572)2.66095799
113actin filament-based movement (GO:0030048)2.65890379
114positive regulation of natural killer cell differentiation (GO:0032825)2.65605775
115response to host (GO:0075136)2.65338491
116response to host defenses (GO:0052200)2.65338491
117response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.65338491
118antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.64867038
119negative regulation of lymphocyte mediated immunity (GO:0002707)2.64606012
120presynaptic membrane organization (GO:0097090)2.64128244
121oxygen transport (GO:0015671)2.63359451
122antigen processing and presentation of endogenous antigen (GO:0019883)2.62584962
123muscle tissue morphogenesis (GO:0060415)2.61342868
124granulocyte activation (GO:0036230)2.60444647
125response to epinephrine (GO:0071871)2.60219726
126neutrophil activation (GO:0042119)2.59869285
127otic vesicle formation (GO:0030916)2.59058729
128positive regulation of mast cell activation (GO:0033005)2.59025185
129phagocytosis, recognition (GO:0006910)2.58880632
130regulation of cardiac muscle cell contraction (GO:0086004)2.58234590
131bundle of His cell to Purkinje myocyte communication (GO:0086069)2.56543747
132negative regulation of interleukin-8 production (GO:0032717)2.54884934
133gas transport (GO:0015669)2.54672437
134organ growth (GO:0035265)2.54609302
135regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.54106580
136regulation of dendritic cell antigen processing and presentation (GO:0002604)2.53679649
137regulation of necroptotic process (GO:0060544)2.53090810
138antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.51079752
139regulation of cardiac muscle contraction (GO:0055117)2.50898396
140regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.50832126
141negative regulation of granulocyte differentiation (GO:0030853)2.50523988
142amyloid precursor protein metabolic process (GO:0042982)2.49898178
143negative regulation of T cell mediated immunity (GO:0002710)2.49424093
144positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.49291517
145regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.48326523
146positive regulation of mast cell degranulation (GO:0043306)2.47827639
147positive regulation of mast cell activation involved in immune response (GO:0033008)2.47827639
148regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.47464498
149leukocyte degranulation (GO:0043299)2.45588508
150regulation of collateral sprouting (GO:0048670)2.44108822
151production of molecular mediator involved in inflammatory response (GO:0002532)2.44073011
152cerebral cortex radially oriented cell migration (GO:0021799)2.43403127
153erythrocyte development (GO:0048821)2.43036714
154ventricular cardiac muscle cell action potential (GO:0086005)2.42547205
155positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.42449196
156embryonic process involved in female pregnancy (GO:0060136)2.41877308
157adhesion of symbiont to host (GO:0044406)2.40584989
158regulation of lipoprotein metabolic process (GO:0050746)2.40123334
159cardiac muscle contraction (GO:0060048)2.40088716
160negative regulation of complement activation (GO:0045916)2.39911192
161regulation of regulated secretory pathway (GO:1903305)2.39578440
162microglial cell activation (GO:0001774)2.38688372
163low-density lipoprotein particle clearance (GO:0034383)2.38641696
164negative regulation of leukocyte mediated immunity (GO:0002704)2.38474325
165regulation of B cell receptor signaling pathway (GO:0050855)2.37582103
166regulation of type 2 immune response (GO:0002828)2.35702258
167asymmetric protein localization (GO:0008105)2.35523693
168negative regulation of type 2 immune response (GO:0002829)2.34735078
169glycosphingolipid catabolic process (GO:0046479)2.33974101
170regulation of macrophage cytokine production (GO:0010935)2.33889701
171respiratory burst (GO:0045730)2.32681996
172positive regulation of tumor necrosis factor production (GO:0032760)2.32337216
173negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.32174878
174membrane assembly (GO:0071709)2.31095007
175myeloid cell development (GO:0061515)2.31030790
176response to lipoprotein particle (GO:0055094)2.30793218
177positive regulation of osteoblast proliferation (GO:0033690)2.30622673
178oligosaccharide catabolic process (GO:0009313)2.29162591
179response to inactivity (GO:0014854)2.29101373
180membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.28387098
181apical protein localization (GO:0045176)2.27710117
182positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.26072798
183glomerular basement membrane development (GO:0032836)2.25448544
184negative regulation of neurotransmitter secretion (GO:0046929)2.23463526
185negative regulation of neurotransmitter transport (GO:0051589)2.22960379
186lateral sprouting from an epithelium (GO:0060601)2.22840527
187regulation of sarcomere organization (GO:0060297)2.22799951
188response to catecholamine (GO:0071869)2.22199281
189response to monoamine (GO:0071867)2.22199281
190negative regulation of execution phase of apoptosis (GO:1900118)2.22196945
191striated muscle contraction (GO:0006941)2.22133608
192short-term memory (GO:0007614)2.21698068
193cellular response to catecholamine stimulus (GO:0071870)2.21600615
194cellular response to monoamine stimulus (GO:0071868)2.21600615
195GPI anchor biosynthetic process (GO:0006506)2.20780881
196establishment of mitochondrion localization (GO:0051654)2.20503087
197regulation of membrane repolarization (GO:0060306)2.17428084
198skeletal muscle contraction (GO:0003009)2.16583606
199glycerophospholipid catabolic process (GO:0046475)2.16234134

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human3.48874552
2IRF8_22096565_ChIP-ChIP_GC-B_Human2.87844809
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.73902700
4VDR_21846776_ChIP-Seq_THP-1_Human2.72403345
5* SPI1_23127762_ChIP-Seq_K562_Human2.58435688
6GATA1_19941826_ChIP-Seq_K562_Human2.56173774
7NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.55764727
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.50311050
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.49209811
10SCL_19346495_ChIP-Seq_HPC-7_Human2.38770636
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.33973442
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.29186839
13* ELK3_25401928_ChIP-Seq_HUVEC_Human2.28942752
14EP300_21415370_ChIP-Seq_HL-1_Mouse2.27914730
15GBX2_23144817_ChIP-Seq_PC3_Human2.27153881
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.26844215
17* NCOR1_26117541_ChIP-Seq_K562_Human2.24074430
18VDR_24763502_ChIP-Seq_THP-1_Human2.23374939
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.19954019
20EZH2_22144423_ChIP-Seq_EOC_Human2.17541090
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.14895245
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.13683044
23CDX2_19796622_ChIP-Seq_MESCs_Mouse2.11808018
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.08669552
25* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.07721666
26KDM2B_26808549_Chip-Seq_SUP-B15_Human2.06185677
27MYC_22102868_ChIP-Seq_BL_Human2.05337152
28LXR_22292898_ChIP-Seq_THP-1_Human2.05208237
29GATA1_22025678_ChIP-Seq_K562_Human2.03578694
30IRF8_27001747_Chip-Seq_BMDM_Mouse2.02096703
31TCF7_22412390_ChIP-Seq_EML_Mouse2.01921151
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.00951795
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99681649
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99681649
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.98337054
36* MAF_26560356_Chip-Seq_TH1_Human1.96733234
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.90570605
38* KDM2B_26808549_Chip-Seq_DND41_Human1.88235312
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87802798
40JARID2_20064375_ChIP-Seq_MESCs_Mouse1.86772980
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86767616
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.86655709
43SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86332802
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.85463392
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.85179309
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80946356
47AR_21572438_ChIP-Seq_LNCaP_Human1.80816589
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.79617153
49MTF2_20144788_ChIP-Seq_MESCs_Mouse1.78700672
50* GATA2_19941826_ChIP-Seq_K562_Human1.77297956
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.74935126
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.73704676
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.73024070
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.71029035
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.68833892
56JARID2_20075857_ChIP-Seq_MESCs_Mouse1.67631654
57TP63_17297297_ChIP-ChIP_HaCaT_Human1.66338806
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.66031455
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.65216162
60TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.65090200
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63918819
62SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.62999212
63* GATA1_19941827_ChIP-Seq_MEL_Mouse1.62521966
64DROSHA_22980978_ChIP-Seq_HELA_Human1.61667448
65* RACK7_27058665_Chip-Seq_MCF-7_Human1.61583439
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.61370313
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60210930
68SPI1_23547873_ChIP-Seq_NB4_Human1.59696825
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57973773
70STAT4_19710469_ChIP-ChIP_TH1__Mouse1.56752392
71RNF2_27304074_Chip-Seq_ESCs_Mouse1.54910055
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53966951
73UTX_26944678_Chip-Seq_JUKART_Human1.53430177
74SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53315833
75MAF_26560356_Chip-Seq_TH2_Human1.52841237
76* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.51734475
77* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50967637
78ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.50833507
79KDM2B_26808549_Chip-Seq_K562_Human1.50729381
80* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.48771044
81PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47622517
82* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42604768
83CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.41897033
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.40568815
85* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40245633
86TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39823982
87RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39763435
88ESR2_21235772_ChIP-Seq_MCF-7_Human1.39365174
89* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38981205
90* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38981205
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38441364
92CJUN_26792858_Chip-Seq_BT549_Human1.37487195
93CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37228844
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36146401
95CBX2_27304074_Chip-Seq_ESCs_Mouse1.36117969
96TP53_18474530_ChIP-ChIP_U2OS_Human1.34866992
97ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34723831
98TP53_16413492_ChIP-PET_HCT116_Human1.34536034
99SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.34453077
100* CLOCK_20551151_ChIP-Seq_293T_Human1.34391221
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34315754
102PPARA_22158963_ChIP-Seq_LIVER_Mouse1.34313943
103RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33429958
104STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33106012
105RXR_22158963_ChIP-Seq_LIVER_Mouse1.32186170
106SMAD_19615063_ChIP-ChIP_OVARY_Human1.32095802
107RUNX_20019798_ChIP-Seq_JUKART_Human1.30317612
108* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.30126922
109SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30081646
110* KDM2B_26808549_Chip-Seq_JURKAT_Human1.29114319
111* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.29082317
112* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26775584
113MYB_26560356_Chip-Seq_TH1_Human1.25192711
114PIAS1_25552417_ChIP-Seq_VCAP_Human1.24995013
115VDR_24787735_ChIP-Seq_THP-1_Human1.24813615
116BP1_19119308_ChIP-ChIP_Hs578T_Human1.24034780
117KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23882678
118TAF15_26573619_Chip-Seq_HEK293_Human1.23080005
119WT1_19549856_ChIP-ChIP_CCG9911_Human1.22044505
120CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21494569
121AHR_22903824_ChIP-Seq_MCF-7_Human1.21231151
122RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21130578
123ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21104321
124VDR_22108803_ChIP-Seq_LS180_Human1.20884745
125OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20486066
126GATA2_21666600_ChIP-Seq_HMVEC_Human1.18758880
127LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17911072
128MYB_26560356_Chip-Seq_TH2_Human1.17643605
129ZNF263_19887448_ChIP-Seq_K562_Human1.17412096
130* TBX20_22080862_ChIP-Seq_HEART_Mouse1.17090513
131* TBX20_22328084_ChIP-Seq_HEART_Mouse1.17090513
132ESR1_20079471_ChIP-ChIP_T-47D_Human1.16482697
133GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16277451
134* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15916287
135ER_23166858_ChIP-Seq_MCF-7_Human1.15333734
136* SA1_27219007_Chip-Seq_ERYTHROID_Human1.14961235
137GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.14338398
138* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14140778
139CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14033995
140IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12919413
141SMAD3_21741376_ChIP-Seq_EPCs_Human1.12054451
142FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09507727
143GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09435826
144GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09291775
145P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08691723
146ARNT_22903824_ChIP-Seq_MCF-7_Human1.07254700
147PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06705714
148TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06571074
149* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04164611
150BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03413068
151FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.03161974
152BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02951316
153* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01279153
154PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99952702
155WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99779442
156SMC4_20622854_ChIP-Seq_HELA_Human0.98536477
157STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98097596
158POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97510491
159CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97216432
160BCOR_27268052_Chip-Seq_Bcells_Human0.96417130
161NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96371122
162P68_20966046_ChIP-Seq_HELA_Human0.96097510
163* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95998517
164* ATF3_27146783_Chip-Seq_COLON_Human0.95994480
165ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95454123
166ESR1_21235772_ChIP-Seq_MCF-7_Human0.93594075
167SMAD3_21741376_ChIP-Seq_HESCs_Human0.93440005
168PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93250117
169SMAD4_21799915_ChIP-Seq_A2780_Human0.92857352
170SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91216379
171P63_26484246_Chip-Seq_KERATINOCYTES_Human0.90495599
172EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90492674
173CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90453819
174TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90423203
175CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88283257
176PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88209933
177RING1B_27294783_Chip-Seq_ESCs_Mouse0.87741346
178P300_19829295_ChIP-Seq_ESCs_Human0.86828565
179PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86584541
180CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85379129
181UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85368989
182SUZ12_27294783_Chip-Seq_NPCs_Mouse0.83609063
183JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82416591
184PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.81914420
185TBL1_22424771_ChIP-Seq_293T_Human0.81742052
186SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.81231436
187EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.80961821
188TP53_20018659_ChIP-ChIP_R1E_Mouse0.80677724
189ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79924118

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.30712611
2MP0003950_abnormal_plasma_membrane4.25767053
3MP0000751_myopathy3.62164808
4MP0002837_dystrophic_cardiac_calcinosis3.54319432
5MP0000920_abnormal_myelination3.11697204
6MP0000749_muscle_degeneration2.98234238
7MP0003436_decreased_susceptibility_to2.97416982
8MP0003705_abnormal_hypodermis_morpholog2.85690476
9MP0005503_abnormal_tendon_morphology2.84848411
10MP0005275_abnormal_skin_tensile2.84346362
11MP0003303_peritoneal_inflammation2.62354876
12MP0005058_abnormal_lysosome_morphology2.51257053
13MP0004036_abnormal_muscle_relaxation2.44010053
14MP0004084_abnormal_cardiac_muscle2.42955177
15MP0003136_yellow_coat_color2.40753691
16MP0005171_absent_coat_pigmentation2.33191562
17MP0002419_abnormal_innate_immunity2.31037849
18MP0009278_abnormal_bone_marrow2.30395634
19MP0005330_cardiomyopathy2.28893683
20MP0003172_abnormal_lysosome_physiology2.15922833
21MP0004215_abnormal_myocardial_fiber2.06601092
22MP0001835_abnormal_antigen_presentation2.04616746
23MP0001958_emphysema2.03471696
24MP0003646_muscle_fatigue2.03083080
25MP0005397_hematopoietic_system_phenotyp2.00833373
26MP0001545_abnormal_hematopoietic_system2.00833373
27MP0004145_abnormal_muscle_electrophysio1.95096360
28MP0005451_abnormal_body_composition1.94729545
29MP0005025_abnormal_response_to1.89986742
30MP0003191_abnormal_cellular_cholesterol1.89337975
31MP0003300_gastrointestinal_ulcer1.84927998
32MP0006082_CNS_inflammation1.82350894
33MP0003137_abnormal_impulse_conducting1.80596043
34MP0003656_abnormal_erythrocyte_physiolo1.80059288
35MP0009840_abnormal_foam_cell1.79611356
36MP0004947_skin_inflammation1.79397988
37MP0002132_abnormal_respiratory_system1.77642879
38MP0005076_abnormal_cell_differentiation1.75760578
39MP0005387_immune_system_phenotype1.75413283
40MP0001790_abnormal_immune_system1.75413283
41MP0004087_abnormal_muscle_fiber1.74678363
42MP0002108_abnormal_muscle_morphology1.73798479
43MP0005620_abnormal_muscle_contractility1.72339246
44MP0005083_abnormal_biliary_tract1.72136365
45MP0002972_abnormal_cardiac_muscle1.70602508
46MP0000747_muscle_weakness1.69754665
47MP0005623_abnormal_meninges_morphology1.62844327
48MP0005409_darkened_coat_color1.60922334
49MP0005464_abnormal_platelet_physiology1.59957434
50MP0005369_muscle_phenotype1.58010293
51MP0003279_aneurysm1.57939788
52MP0002148_abnormal_hypersensitivity_rea1.57939364
53MP0003690_abnormal_glial_cell1.57870131
54MP0009785_altered_susceptibility_to1.57512402
55MP0000685_abnormal_immune_system1.56899639
56MP0004381_abnormal_hair_follicle1.56687365
57MP0004272_abnormal_basement_membrane1.56166146
58MP0005000_abnormal_immune_tolerance1.55352823
59MP0001533_abnormal_skeleton_physiology1.54608717
60MP0002106_abnormal_muscle_physiology1.54078189
61MP0000759_abnormal_skeletal_muscle1.53796071
62MP0008004_abnormal_stomach_pH1.49612364
63MP0000750_abnormal_muscle_regeneration1.49212206
64MP0002452_abnormal_antigen_presenting1.46222714
65MP0002723_abnormal_immune_serum1.45165896
66MP0004484_altered_response_of1.43254008
67MP0002405_respiratory_system_inflammati1.42544454
68MP0000566_synostosis1.41542644
69MP0000762_abnormal_tongue_morphology1.41451304
70MP0004883_abnormal_blood_vessel1.41337271
71MP0000383_abnormal_hair_follicle1.39188294
72MP0002295_abnormal_pulmonary_circulatio1.38527810
73MP0003828_pulmonary_edema1.38213421
74MP0006138_congestive_heart_failure1.37877424
75MP0008775_abnormal_heart_ventricle1.37016897
76MP0004233_abnormal_muscle_weight1.36662232
77MP0002998_abnormal_bone_remodeling1.35614634
78MP0001800_abnormal_humoral_immune1.34903252
79MP0004742_abnormal_vestibular_system1.33761139
80MP0002420_abnormal_adaptive_immunity1.33317067
81MP0001819_abnormal_immune_cell1.33246248
82MP0000579_abnormal_nail_morphology1.31610961
83MP0005164_abnormal_response_to1.31459912
84MP0000858_altered_metastatic_potential1.30380114
85MP0002933_joint_inflammation1.28364792
86MP0009384_cardiac_valve_regurgitation1.22777703
87MP0003634_abnormal_glial_cell1.22366189
88MP0003091_abnormal_cell_migration1.21815097
89MP0000678_abnormal_parathyroid_gland1.19851560
90MP0002396_abnormal_hematopoietic_system1.18336636
91MP0005385_cardiovascular_system_phenoty1.18213393
92MP0001544_abnormal_cardiovascular_syste1.18213393
93MP0005671_abnormal_response_to1.17693490
94MP0002060_abnormal_skin_morphology1.16667687
95MP0004134_abnormal_chest_morphology1.13741078
96MP0004808_abnormal_hematopoietic_stem1.12539413
97MP0003880_abnormal_central_pattern1.12459047
98MP0002398_abnormal_bone_marrow1.08142318
99MP0009115_abnormal_fat_cell1.07912351
100MP0004085_abnormal_heartbeat1.07867994
101MP0004142_abnormal_muscle_tone1.06967176
102MP0004510_myositis1.06799182
103MP0010630_abnormal_cardiac_muscle1.06663713
104MP0001845_abnormal_inflammatory_respons1.05668053
105MP0008469_abnormal_protein_level1.05023738
106MP0000733_abnormal_muscle_development1.04243375
107MP0005508_abnormal_skeleton_morphology1.03368401
108MP0010678_abnormal_skin_adnexa1.02925073
109MP0005023_abnormal_wound_healing1.02219048
110MP0002133_abnormal_respiratory_system1.02076983
111MP0005388_respiratory_system_phenotype1.02076983
112MP0000716_abnormal_immune_system1.01479027
113MP0002971_abnormal_brown_adipose1.01025129
114MP0002722_abnormal_immune_system0.99387641
115MP0003075_altered_response_to0.99226352
116MP0000343_altered_response_to0.98922219
117MP0002269_muscular_atrophy0.98351485
118MP0001486_abnormal_startle_reflex0.96956726
119MP0001299_abnormal_eye_distance/0.96733031
120MP0004270_analgesia0.96520430
121MP0003453_abnormal_keratinocyte_physiol0.94869114
122MP0003329_amyloid_beta_deposits0.94242632
123MP0003941_abnormal_skin_development0.94036899
124MP0002272_abnormal_nervous_system0.93425746
125MP0001853_heart_inflammation0.93302228
126MP0003045_fibrosis0.91930159
127MP0010368_abnormal_lymphatic_system0.91286911
128MP0001879_abnormal_lymphatic_vessel0.91271463
129MP0002429_abnormal_blood_cell0.91268472
130MP0002877_abnormal_melanocyte_morpholog0.90998597
131MP0004185_abnormal_adipocyte_glucose0.88569909
132MP0002234_abnormal_pharynx_morphology0.88440520
133MP0000689_abnormal_spleen_morphology0.88402290
134MP0003566_abnormal_cell_adhesion0.88149570
135MP0001346_abnormal_lacrimal_gland0.87773663
136MP0005165_increased_susceptibility_to0.87184322
137MP0002332_abnormal_exercise_endurance0.85996196
138MP0000249_abnormal_blood_vessel0.85528701
139MP0010155_abnormal_intestine_physiology0.84840530
140MP0000467_abnormal_esophagus_morphology0.84384871
141MP0000778_abnormal_nervous_system0.83596245
142MP0009250_abnormal_appendicular_skeleto0.82901901
143MP0005595_abnormal_vascular_smooth0.82644555
144MP0009333_abnormal_splenocyte_physiolog0.82234488
145MP0005166_decreased_susceptibility_to0.81492207
146MP0006054_spinal_hemorrhage0.81070865
147MP0000462_abnormal_digestive_system0.81025049
148MP0004130_abnormal_muscle_cell0.80847722
149MP0001485_abnormal_pinna_reflex0.80642396
150MP0004885_abnormal_endolymph0.80218602
151MP0008260_abnormal_autophagy0.79578094
152MP0003632_abnormal_nervous_system0.78718117
153MP0003448_altered_tumor_morphology0.78326932
154MP0001542_abnormal_bone_strength0.78226739
155MP0009764_decreased_sensitivity_to0.76569199
156MP0005375_adipose_tissue_phenotype0.76560803
157MP0005390_skeleton_phenotype0.75650741
158MP0001905_abnormal_dopamine_level0.74973977
159MP0001177_atelectasis0.74481026
160MP0005666_abnormal_adipose_tissue0.74358126
161MP0000647_abnormal_sebaceous_gland0.70138809
162MP0002249_abnormal_larynx_morphology0.68663882
163MP0005670_abnormal_white_adipose0.67014116
164MP0001851_eye_inflammation0.66090658
165MP0002090_abnormal_vision0.66039309
166MP0003724_increased_susceptibility_to0.65370108
167MP0002796_impaired_skin_barrier0.65147045
168MP0001529_abnormal_vocalization0.62757598
169MP0002229_neurodegeneration0.61233151

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber splitting (HP:0003555)5.91325437
2Hyporeflexia of lower limbs (HP:0002600)4.74083552
3Premature rupture of membranes (HP:0001788)4.29276953
4Sudden death (HP:0001699)4.26927232
5Muscle hypertrophy of the lower extremities (HP:0008968)4.17186301
6Abnormality of macrophages (HP:0004311)4.00646725
7Calf muscle hypertrophy (HP:0008981)3.99478604
8Polycythemia (HP:0001901)3.98248410
9Ventricular tachycardia (HP:0004756)3.85308034
10Eczematoid dermatitis (HP:0000976)3.84274212
11Atrial fibrillation (HP:0005110)3.82871427
12Abnormality of the calf musculature (HP:0001430)3.78320529
13Difficulty running (HP:0009046)3.70278377
14Cholecystitis (HP:0001082)3.65724354
15Abnormal gallbladder physiology (HP:0012438)3.65724354
16Exercise-induced myalgia (HP:0003738)3.59773220
17Recurrent bacterial skin infections (HP:0005406)3.55591784
18Degeneration of the lateral corticospinal tracts (HP:0002314)3.54675723
19Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.54675723
20Recurrent abscess formation (HP:0002722)3.52906339
21Primary atrial arrhythmia (HP:0001692)3.47051723
22EMG: myopathic abnormalities (HP:0003458)3.41839683
23Type 1 muscle fiber predominance (HP:0003803)3.38134733
24Neurofibrillary tangles (HP:0002185)3.35091493
25Broad metatarsal (HP:0001783)3.32507102
26Parakeratosis (HP:0001036)3.31632429
27Right ventricular cardiomyopathy (HP:0011663)3.24709423
28Supraventricular tachycardia (HP:0004755)3.23405247
29Increased connective tissue (HP:0009025)3.21116599
30Exercise-induced muscle cramps (HP:0003710)3.19824494
31Supraventricular arrhythmia (HP:0005115)3.18746922
32Onion bulb formation (HP:0003383)3.09913198
33Spontaneous hematomas (HP:0007420)3.09872330
34Systemic lupus erythematosus (HP:0002725)3.05511196
35Lipoatrophy (HP:0100578)3.04751429
36Foot dorsiflexor weakness (HP:0009027)2.99499725
37Atrophic scars (HP:0001075)2.97621230
38Muscle fiber inclusion bodies (HP:0100299)2.89468598
39Syncope (HP:0001279)2.89196055
40Distal lower limb amyotrophy (HP:0008944)2.88776854
41Recurrent gram-negative bacterial infections (HP:0005420)2.88403401
42Increased variability in muscle fiber diameter (HP:0003557)2.88296891
43Myositis (HP:0100614)2.87378627
44Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.87287937
45Obstructive lung disease (HP:0006536)2.84255623
46Chronic obstructive pulmonary disease (HP:0006510)2.84255623
47Prolonged QT interval (HP:0001657)2.79905880
48Abnormality of the foot musculature (HP:0001436)2.79715867
49Reticulocytosis (HP:0001923)2.77035869
50Distal lower limb muscle weakness (HP:0009053)2.76536022
51Hypertensive crisis (HP:0100735)2.74328481
52Dilated cardiomyopathy (HP:0001644)2.72275454
53Orchitis (HP:0100796)2.68583926
54Sensory axonal neuropathy (HP:0003390)2.65893223
55Centrally nucleated skeletal muscle fibers (HP:0003687)2.65763057
56Hypoplasia of the iris (HP:0007676)2.64134857
57Abnormality of liposaccharide metabolism (HP:0010968)2.63456620
58Abnormality of glycosphingolipid metabolism (HP:0004343)2.63456620
59Abnormality of glycolipid metabolism (HP:0010969)2.63456620
60Gowers sign (HP:0003391)2.62591169
61Dilatation of the ascending aorta (HP:0005111)2.60122615
62Abnormality of skeletal muscle fiber size (HP:0012084)2.59407888
63Neck muscle weakness (HP:0000467)2.59183695
64Vacuolated lymphocytes (HP:0001922)2.56607265
65Scapular winging (HP:0003691)2.56152379
66Round ear (HP:0100830)2.56002899
67Truncus arteriosus (HP:0001660)2.55714330
68Nemaline bodies (HP:0003798)2.55098594
69Pulmonary artery stenosis (HP:0004415)2.54076493
70Spinal rigidity (HP:0003306)2.52855427
71Interstitial pulmonary disease (HP:0006530)2.51061787
72Subaortic stenosis (HP:0001682)2.49738922
73Abnormality of the left ventricular outflow tract (HP:0011103)2.49738922
74Gastrointestinal infarctions (HP:0005244)2.47455653
75Peritonitis (HP:0002586)2.46402631
76Fragile skin (HP:0001030)2.46266749
77Aortic aneurysm (HP:0004942)2.43212769
78Gingivitis (HP:0000230)2.41716019
79Ankyloglossia (HP:0010296)2.40337162
80Aplasia involving bones of the extremities (HP:0009825)2.39994813
81Aplasia involving bones of the upper limbs (HP:0009823)2.39994813
82Aplasia of the phalanges of the hand (HP:0009802)2.39994813
83Prolonged bleeding time (HP:0003010)2.35840671
84Increased IgE level (HP:0003212)2.35659247
85Steppage gait (HP:0003376)2.35505137
86Abnormality of the fingertips (HP:0001211)2.34270778
87Retrobulbar optic neuritis (HP:0100654)2.33607015
88Optic neuritis (HP:0100653)2.33607015
89Axonal loss (HP:0003447)2.33267551
90Recurrent fungal infections (HP:0002841)2.32288659
91Lower limb amyotrophy (HP:0007210)2.31986445
92Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.29487891
93Recurrent skin infections (HP:0001581)2.29104554
94Myocardial infarction (HP:0001658)2.29086238
95Ulnar deviation of the wrist (HP:0003049)2.28497274
96Asymmetric septal hypertrophy (HP:0001670)2.28221197
97Infantile muscular hypotonia (HP:0008947)2.27158181
98Bowel incontinence (HP:0002607)2.23544013
99Duplicated collecting system (HP:0000081)2.22192018
100Cerebral aneurysm (HP:0004944)2.21926678
101Alacrima (HP:0000522)2.21584726
102Nonimmune hydrops fetalis (HP:0001790)2.21565103
103Epistaxis (HP:0000421)2.21271076
104Peripheral hypomyelination (HP:0007182)2.21232322
105Hip contracture (HP:0003273)2.20639725
106Shallow orbits (HP:0000586)2.20201472
107Dysostosis multiplex (HP:0000943)2.18030792
108Stridor (HP:0010307)2.17975288
109Colitis (HP:0002583)2.16838240
110Limited hip movement (HP:0008800)2.15716340
111Myotonia (HP:0002486)2.15218433
112Esophageal varix (HP:0002040)2.15199476
113Abnormal large intestine physiology (HP:0012700)2.14849045
114Keratoconjunctivitis sicca (HP:0001097)2.12264010
115Cellulitis (HP:0100658)2.10275917
116Protrusio acetabuli (HP:0003179)2.09979407
117Bradycardia (HP:0001662)2.09929527
118Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.09519832
119Hemorrhage of the eye (HP:0011885)2.09307130
120Increased serum ferritin (HP:0003281)2.09300224
121Weak cry (HP:0001612)2.07954970
122Cerebral inclusion bodies (HP:0100314)2.07742969
123Bundle branch block (HP:0011710)2.07546350
124Cholelithiasis (HP:0001081)2.07490611
125Abnormality of the corticospinal tract (HP:0002492)2.07398263
126Aneurysm (HP:0002617)2.06652691
127Myopathic facies (HP:0002058)2.05262591
128Increased cerebral lipofuscin (HP:0011813)2.04810564
129Abnormality of glycosaminoglycan metabolism (HP:0004371)2.03969310
130Abnormality of mucopolysaccharide metabolism (HP:0011020)2.03969310
131Abnormality of polysaccharide metabolism (HP:0011012)2.03969310
132Recurrent cutaneous fungal infections (HP:0011370)2.03876829
133Chronic mucocutaneous candidiasis (HP:0002728)2.03876829
134Pustule (HP:0200039)2.03363755
135Follicular hyperkeratosis (HP:0007502)2.01735109
136Abnormality of the peritoneum (HP:0002585)2.01537217
137Mucopolysacchariduria (HP:0008155)2.01160388
138Urinary glycosaminoglycan excretion (HP:0003541)2.01160388
139Atelectasis (HP:0100750)2.00257079
140Amyloidosis (HP:0011034)1.99664693
141Mildly elevated creatine phosphokinase (HP:0008180)1.99172255
142Bell-shaped thorax (HP:0001591)1.98565719
143Hyperthyroidism (HP:0000836)1.98116548
144Abnormality of the tricuspid valve (HP:0001702)1.96594377
145Ventricular arrhythmia (HP:0004308)1.96353722
146Premature skin wrinkling (HP:0100678)1.96192872
147Acne (HP:0001061)1.95953489
148Mediastinal lymphadenopathy (HP:0100721)1.94581254
149Diaphragmatic weakness (HP:0009113)1.93949678
150Abnormality of complement system (HP:0005339)1.92674509
151Arterial thrombosis (HP:0004420)1.91970527
152Abnormality of oral frenula (HP:0000190)1.89973474
153Segmental peripheral demyelination/remyelination (HP:0003481)1.89763535
154Abnormal atrioventricular conduction (HP:0005150)1.89608517
155Muscular dystrophy (HP:0003560)1.87258572
156Gastrointestinal dysmotility (HP:0002579)1.86936114
157Keratoconjunctivitis (HP:0001096)1.86649186
158Seborrheic dermatitis (HP:0001051)1.86562382
159Synostosis involving the elbow (HP:0003938)1.84845605
160Humeroradial synostosis (HP:0003041)1.84845605
161Absent septum pellucidum (HP:0001331)1.84569419
162Elevated erythrocyte sedimentation rate (HP:0003565)1.84558005
163Hypertriglyceridemia (HP:0002155)1.84007565
164Soft skin (HP:0000977)1.82897514
165Muscle stiffness (HP:0003552)1.82386810
166Large for gestational age (HP:0001520)1.82334762
167Metaphyseal cupping (HP:0003021)1.82142562
168Abnormal EKG (HP:0003115)1.81065167
169Cervical subluxation (HP:0003308)1.79998477
170Hemoptysis (HP:0002105)1.78159419
171Heart block (HP:0012722)1.77624261
172Double outlet right ventricle (HP:0001719)1.77139870
173Congenital malformation of the right heart (HP:0011723)1.77139870
174Coronal craniosynostosis (HP:0004440)1.76570905
175Abnormality of the renal collecting system (HP:0004742)1.76358844
176White forelock (HP:0002211)1.76349568
177Fragile nails (HP:0001808)1.76241106
178Aortic dissection (HP:0002647)1.76039509
179Abnormality of the common coagulation pathway (HP:0010990)1.75637117
180Gingival bleeding (HP:0000225)1.75165643
181Venous abnormality (HP:0002624)1.74614742
182Thickened helices (HP:0000391)1.74274767
183Abnormal auditory evoked potentials (HP:0006958)1.72610478
184Congenital ichthyosiform erythroderma (HP:0007431)1.72289013

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.31914218
2RIPK44.10508552
3EPHB13.54858441
4TTN3.43888048
5ERN12.99079298
6OBSCN2.85700580
7PKN12.79319935
8KSR22.64036649
9MAP2K32.63955805
10OXSR12.55249530
11PHKG12.41250591
12PHKG22.41250591
13TRIB32.33966876
14TYK22.32881536
15MUSK2.20812021
16DMPK2.03691300
17CASK1.92737086
18TRPM71.83142574
19CAMK2D1.81434894
20ZAP701.79323256
21WNK41.76139513
22CDK121.75717824
23MAP3K21.74698441
24PIK3CA1.72024534
25MET1.69370876
26WNK11.68580731
27EEF2K1.67981820
28JAK31.67722088
29ROCK21.67453230
30MAPKAPK51.66819042
31BCR1.62243012
32MAP3K61.59385395
33MYLK1.59032444
34TIE11.56348414
35MAP3K11.55943084
36CSK1.55636647
37FGFR21.49215510
38NEK61.45024562
39IRAK41.42798144
40RAF11.41595617
41EPHB21.39803945
42PAK31.35609576
43MAP3K31.33938095
44JAK21.31906397
45PBK1.29573369
46PRKD11.28776335
47CAMK2B1.27610627
48GRK71.24359706
49FGFR41.21765686
50SIK11.21450156
51MST41.20517468
52IRAK31.20250067
53PRKCE1.20015577
54BMPR21.19253885
55INSRR1.17794885
56CLK11.16691189
57CAMK2G1.16598076
58DDR21.15826364
59MAP4K11.12912733
60BTK1.10943708
61HCK1.09882899
62FES1.05139908
63PINK11.04366979
64JAK11.04252611
65LMTK21.04032405
66TBK11.02594715
67LATS10.99268502
68TAOK20.99125942
69EPHA30.98924579
70CAMK2A0.98170694
71PTK60.97774580
72BMPR1B0.96511650
73KSR10.95352640
74PKN20.92360294
75ICK0.92142249
76RIPK10.91810240
77SGK2230.91596656
78SGK4940.91596656
79MAPK150.89731274
80MAP3K130.87892524
81SYK0.86728945
82FGR0.86658112
83PRPF4B0.86573585
84ZAK0.86239843
85MTOR0.85994648
86PAK60.85851364
87PIK3CG0.83980878
88ROCK10.83644365
89EPHA20.82274936
90RET0.80792083
91MAP3K80.80764921
92NUAK10.80701419
93CAMK1D0.79612546
94CSNK1A1L0.78935068
95PDGFRA0.78147434
96BLK0.77048371
97NTRK10.75514899
98TNK20.75255080
99TAOK10.72617785
100FGFR30.70121916
101MARK30.69753911
102MARK20.69577299
103RPS6KA20.69253317
104PRKCH0.69137741
105GRK60.68992467
106EPHA40.66880671
107NME10.66433317
108MAP2K10.66352841
109MAP3K70.65900283
110PDK20.64692688
111PRKCQ0.64633816
112YES10.64538429
113RPS6KC10.64011213
114RPS6KL10.64011213
115PRKG10.63866637
116MATK0.63126330
117PDK10.60572512
118UHMK10.60104015
119PRKD20.59749634
120STK380.59716067
121LATS20.59303923
122MAP3K140.59043943
123LYN0.58827581
124MAP2K20.58119926
125FER0.58074284
126PDGFRB0.56210234
127GSK3A0.54275366
128HIPK20.54068343
129MAPK120.53925798
130NEK90.53519584
131LIMK10.53369693
132CSNK1G30.53014355
133PRKAA20.52589057
134SMG10.52451605
135PTK2B0.51845252
136LCK0.51647088
137TNIK0.51092550
138IRAK10.50626177
139IKBKE0.50009566
140GRK10.49869207
141KIT0.49333087
142CDK190.49026139
143TAOK30.48841052
144PRKG20.48828288
145PDPK10.48779348
146AKT30.48385343
147MAPKAPK20.48136184
148RPS6KA60.48021091
149IKBKB0.47835182
150BMX0.47178096
151CSNK1G10.46974647
152STK100.46947937
153MAP2K60.46870910
154ILK0.46025278
155STK40.44424961
156TGFBR20.44381431
157PAK20.44087283
158PRKACB0.43814965
159CDC42BPA0.42996428
160PRKACA0.42367939
161RPS6KA50.40322368
162MAPK70.40064658
163IRAK20.39792339
164SGK10.39754629
165DAPK30.39673627
166CAMK1G0.39634836
167FYN0.39089217
168DYRK20.38925309
169STK30.35652796

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.00338786
2Fatty acid elongation_Homo sapiens_hsa000623.70547281
3Other glycan degradation_Homo sapiens_hsa005113.25413060
4Dilated cardiomyopathy_Homo sapiens_hsa054142.96139873
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.95109474
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.66312559
7Staphylococcus aureus infection_Homo sapiens_hsa051502.62194859
8Osteoclast differentiation_Homo sapiens_hsa043802.59443900
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.54705130
10Leishmaniasis_Homo sapiens_hsa051402.44399135
11ECM-receptor interaction_Homo sapiens_hsa045122.38342594
12Cardiac muscle contraction_Homo sapiens_hsa042602.37143025
13Acute myeloid leukemia_Homo sapiens_hsa052212.36671428
14Steroid biosynthesis_Homo sapiens_hsa001002.23687146
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.05959469
16Ether lipid metabolism_Homo sapiens_hsa005651.97886603
17Tuberculosis_Homo sapiens_hsa051521.83602331
18B cell receptor signaling pathway_Homo sapiens_hsa046621.78369977
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.77249820
20Oxidative phosphorylation_Homo sapiens_hsa001901.76878736
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.74558763
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.73710348
23Axon guidance_Homo sapiens_hsa043601.68761669
24Sphingolipid metabolism_Homo sapiens_hsa006001.68494629
25Chronic myeloid leukemia_Homo sapiens_hsa052201.65397638
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.61684888
27Alzheimers disease_Homo sapiens_hsa050101.51503953
28Toxoplasmosis_Homo sapiens_hsa051451.44298274
29Pertussis_Homo sapiens_hsa051331.42359454
30Parkinsons disease_Homo sapiens_hsa050121.40841840
31VEGF signaling pathway_Homo sapiens_hsa043701.39806667
32Complement and coagulation cascades_Homo sapiens_hsa046101.38003471
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37707936
34TNF signaling pathway_Homo sapiens_hsa046681.31900224
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.31245532
36Tight junction_Homo sapiens_hsa045301.30736199
37Influenza A_Homo sapiens_hsa051641.30595127
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.29953582
39Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.29381394
40Non-small cell lung cancer_Homo sapiens_hsa052231.28959407
41Focal adhesion_Homo sapiens_hsa045101.28823640
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.28755574
43Pancreatic cancer_Homo sapiens_hsa052121.28587212
44Hematopoietic cell lineage_Homo sapiens_hsa046401.27282832
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25599280
46Malaria_Homo sapiens_hsa051441.24260806
47Legionellosis_Homo sapiens_hsa051341.24114432
48Vascular smooth muscle contraction_Homo sapiens_hsa042701.18437546
49Linoleic acid metabolism_Homo sapiens_hsa005911.18079837
50Arachidonic acid metabolism_Homo sapiens_hsa005901.15285171
51Fructose and mannose metabolism_Homo sapiens_hsa000511.14316329
52Histidine metabolism_Homo sapiens_hsa003401.12875843
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12756049
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12321278
55Chemokine signaling pathway_Homo sapiens_hsa040621.11278161
56Measles_Homo sapiens_hsa051621.10765536
57Propanoate metabolism_Homo sapiens_hsa006401.10575302
58Arginine and proline metabolism_Homo sapiens_hsa003301.08923213
59Hepatitis B_Homo sapiens_hsa051611.08750681
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07531661
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04471549
62Insulin resistance_Homo sapiens_hsa049311.03280112
63Regulation of actin cytoskeleton_Homo sapiens_hsa048101.03077249
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.03057700
65Insulin signaling pathway_Homo sapiens_hsa049101.02950616
66mTOR signaling pathway_Homo sapiens_hsa041501.02495487
67Prolactin signaling pathway_Homo sapiens_hsa049171.01746787
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01709266
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00727396
70Adipocytokine signaling pathway_Homo sapiens_hsa049201.00181559
71HIF-1 signaling pathway_Homo sapiens_hsa040660.99765259
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.99279383
73Serotonergic synapse_Homo sapiens_hsa047260.96647761
74Ovarian steroidogenesis_Homo sapiens_hsa049130.94825985
75Hepatitis C_Homo sapiens_hsa051600.94198038
76Prion diseases_Homo sapiens_hsa050200.93166057
77Bladder cancer_Homo sapiens_hsa052190.92715115
78Type II diabetes mellitus_Homo sapiens_hsa049300.92005937
79Protein digestion and absorption_Homo sapiens_hsa049740.89671011
80Pentose phosphate pathway_Homo sapiens_hsa000300.89102433
81Amoebiasis_Homo sapiens_hsa051460.89077452
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88123648
83Gastric acid secretion_Homo sapiens_hsa049710.88114230
84Viral myocarditis_Homo sapiens_hsa054160.86217372
85Renin secretion_Homo sapiens_hsa049240.85892062
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.85763215
87GnRH signaling pathway_Homo sapiens_hsa049120.85659393
88Renal cell carcinoma_Homo sapiens_hsa052110.83542565
89Ras signaling pathway_Homo sapiens_hsa040140.83049476
90Fatty acid metabolism_Homo sapiens_hsa012120.82170158
91Galactose metabolism_Homo sapiens_hsa000520.81885114
92Rheumatoid arthritis_Homo sapiens_hsa053230.81617657
93Apoptosis_Homo sapiens_hsa042100.81442674
94Shigellosis_Homo sapiens_hsa051310.80295277
95Autoimmune thyroid disease_Homo sapiens_hsa053200.80190450
96Taste transduction_Homo sapiens_hsa047420.80093824
97Morphine addiction_Homo sapiens_hsa050320.79761725
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.79440708
99Calcium signaling pathway_Homo sapiens_hsa040200.78361428
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.78309410
101African trypanosomiasis_Homo sapiens_hsa051430.78061502
102Salivary secretion_Homo sapiens_hsa049700.76777365
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76750154
104Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75960526
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75761609
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75117154
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72367870
108GABAergic synapse_Homo sapiens_hsa047270.70721826
109Herpes simplex infection_Homo sapiens_hsa051680.70666181
110FoxO signaling pathway_Homo sapiens_hsa040680.70536532
111T cell receptor signaling pathway_Homo sapiens_hsa046600.69770880
112Glutamatergic synapse_Homo sapiens_hsa047240.69597340
113cAMP signaling pathway_Homo sapiens_hsa040240.69506307
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.69217526
115Vitamin B6 metabolism_Homo sapiens_hsa007500.68854779
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68836261
117Oxytocin signaling pathway_Homo sapiens_hsa049210.67795333
118Circadian entrainment_Homo sapiens_hsa047130.67061559
119Choline metabolism in cancer_Homo sapiens_hsa052310.64870884
120Sulfur metabolism_Homo sapiens_hsa009200.64671266
121Thyroid cancer_Homo sapiens_hsa052160.64543493
122Basal cell carcinoma_Homo sapiens_hsa052170.63895198
123Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63843872
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.63625765
125Hedgehog signaling pathway_Homo sapiens_hsa043400.63615902
126Allograft rejection_Homo sapiens_hsa053300.63325424
127Endometrial cancer_Homo sapiens_hsa052130.62410129
128Lysosome_Homo sapiens_hsa041420.62113405
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60810932
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60191781
131Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58629144
132Phototransduction_Homo sapiens_hsa047440.58322205
133Proteoglycans in cancer_Homo sapiens_hsa052050.57270853
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55904867
135Phagosome_Homo sapiens_hsa041450.55789768
136Cocaine addiction_Homo sapiens_hsa050300.55047333
137Huntingtons disease_Homo sapiens_hsa050160.54752561
138Rap1 signaling pathway_Homo sapiens_hsa040150.54647528
139Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54325929
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.53677704
141Inositol phosphate metabolism_Homo sapiens_hsa005620.53519381
142Viral carcinogenesis_Homo sapiens_hsa052030.52313427
143Dorso-ventral axis formation_Homo sapiens_hsa043200.51945864
144Mineral absorption_Homo sapiens_hsa049780.51409022
145Pancreatic secretion_Homo sapiens_hsa049720.50897543
146MAPK signaling pathway_Homo sapiens_hsa040100.50867735
147Melanogenesis_Homo sapiens_hsa049160.50631424
148HTLV-I infection_Homo sapiens_hsa051660.50590797
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49755909
150Graft-versus-host disease_Homo sapiens_hsa053320.49159140
151Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48716314
152Glioma_Homo sapiens_hsa052140.48116852
153beta-Alanine metabolism_Homo sapiens_hsa004100.47858474
154Adherens junction_Homo sapiens_hsa045200.46947535
155Prostate cancer_Homo sapiens_hsa052150.46891643
156Cholinergic synapse_Homo sapiens_hsa047250.46223299
157Estrogen signaling pathway_Homo sapiens_hsa049150.45880323
158Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45296352
159Wnt signaling pathway_Homo sapiens_hsa043100.44853427
160Notch signaling pathway_Homo sapiens_hsa043300.44549225
161MicroRNAs in cancer_Homo sapiens_hsa052060.43575281
162Long-term depression_Homo sapiens_hsa047300.42646835
163Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42367127
164Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41733538
165ABC transporters_Homo sapiens_hsa020100.40597502
166ErbB signaling pathway_Homo sapiens_hsa040120.39756434
167AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39700363
168Salmonella infection_Homo sapiens_hsa051320.39470198
169Pathways in cancer_Homo sapiens_hsa052000.37997005
170Vitamin digestion and absorption_Homo sapiens_hsa049770.37913083
171Hippo signaling pathway_Homo sapiens_hsa043900.36517349
172Platelet activation_Homo sapiens_hsa046110.34681521
173Endocytosis_Homo sapiens_hsa041440.34068901

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