ADAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.44741034
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.72891409
3locomotory exploration behavior (GO:0035641)5.55402625
4synaptic vesicle exocytosis (GO:0016079)5.40743772
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.34242632
6glutamate secretion (GO:0014047)5.30337981
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.25891068
8vocalization behavior (GO:0071625)5.15738019
9regulation of synaptic vesicle exocytosis (GO:2000300)5.05697693
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.95066320
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.59681029
12layer formation in cerebral cortex (GO:0021819)4.59667853
13protein localization to synapse (GO:0035418)4.57659158
14regulation of glutamate receptor signaling pathway (GO:1900449)4.52575376
15neuronal action potential propagation (GO:0019227)4.50216598
16regulation of synaptic vesicle transport (GO:1902803)4.38766531
17neuron cell-cell adhesion (GO:0007158)4.32873507
18exploration behavior (GO:0035640)4.32211973
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.30008276
20regulation of neuronal synaptic plasticity (GO:0048168)4.26359769
21regulation of synapse structural plasticity (GO:0051823)4.18660042
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.17892449
23neurotransmitter secretion (GO:0007269)4.12289627
24dendritic spine morphogenesis (GO:0060997)4.02556289
25response to peptidoglycan (GO:0032494)3.94795394
26proline transport (GO:0015824)3.89494286
27gamma-aminobutyric acid transport (GO:0015812)3.82133008
28synaptic transmission, glutamatergic (GO:0035249)3.80027001
29negative regulation of cell killing (GO:0031342)3.77592180
30negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.77592180
31cellular potassium ion homeostasis (GO:0030007)3.77349080
32glutamate receptor signaling pathway (GO:0007215)3.76546897
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.70088925
34macrophage activation involved in immune response (GO:0002281)3.67521055
35sodium ion export (GO:0071436)3.60622425
36long-term memory (GO:0007616)3.60059668
37positive regulation of membrane potential (GO:0045838)3.58891941
38neuron-neuron synaptic transmission (GO:0007270)3.58623006
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.55560559
40L-amino acid import (GO:0043092)3.55490770
41glycine transport (GO:0015816)3.55111750
42neurotransmitter-gated ion channel clustering (GO:0072578)3.54414571
43neuromuscular process controlling balance (GO:0050885)3.53756354
44neutrophil activation involved in immune response (GO:0002283)3.51132821
45regulation of dendritic spine morphogenesis (GO:0061001)3.48997578
46activation of protein kinase A activity (GO:0034199)3.45268073
47regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.44826063
48regulation of synaptic plasticity (GO:0048167)3.43208655
49neurotransmitter transport (GO:0006836)3.41818633
50synaptic vesicle endocytosis (GO:0048488)3.38614185
51neuron recognition (GO:0008038)3.38038182
52transmission of nerve impulse (GO:0019226)3.37689140
53mannose metabolic process (GO:0006013)3.33222808
54establishment of mitochondrion localization (GO:0051654)3.33070629
55regulation of postsynaptic membrane potential (GO:0060078)3.32864196
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.30905608
57antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.29841840
58regulation of T-helper 2 cell differentiation (GO:0045628)3.28900427
59G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.28807803
60dendrite morphogenesis (GO:0048813)3.27852100
61central nervous system myelination (GO:0022010)3.27839054
62axon ensheathment in central nervous system (GO:0032291)3.27839054
63regulation of neurotransmitter secretion (GO:0046928)3.27811149
64regulation of mast cell degranulation (GO:0043304)3.26534791
65positive regulation of gamma-delta T cell activation (GO:0046645)3.25509877
66regulation of vesicle fusion (GO:0031338)3.23816817
67modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.23351419
68positive regulation by organism of defense response of other organism involved in symbiotic interact3.23351419
69modulation by symbiont of host immune response (GO:0052553)3.23351419
70positive regulation by symbiont of host defense response (GO:0052509)3.23351419
71modulation by symbiont of host defense response (GO:0052031)3.23351419
72modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.23351419
73vesicle transport along microtubule (GO:0047496)3.22410661
74negative regulation of interleukin-12 production (GO:0032695)3.20709575
75adult walking behavior (GO:0007628)3.20500683
76antigen processing and presentation of endogenous antigen (GO:0019883)3.19490468
77regulation of myeloid leukocyte mediated immunity (GO:0002886)3.16733937
78regulation of ARF protein signal transduction (GO:0032012)3.16671597
79positive regulation of mast cell activation involved in immune response (GO:0033008)3.16304691
80positive regulation of mast cell degranulation (GO:0043306)3.16304691
81positive regulation of synapse maturation (GO:0090129)3.15939869
82gamma-aminobutyric acid signaling pathway (GO:0007214)3.15870808
83regulation of leukocyte degranulation (GO:0043300)3.15425606
84nerve growth factor signaling pathway (GO:0038180)3.15014767
85organelle transport along microtubule (GO:0072384)3.14865613
86regulation of dendritic spine development (GO:0060998)3.13270840
87regulation of neurotransmitter levels (GO:0001505)3.12541951
88antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.12487631
89neutrophil activation (GO:0042119)3.12476438
90auditory behavior (GO:0031223)3.11841367
91negative regulation of microtubule polymerization (GO:0031115)3.11692790
92negative regulation of erythrocyte differentiation (GO:0045647)3.09595518
93negative regulation of synaptic transmission, GABAergic (GO:0032229)3.09419758
94long-term synaptic potentiation (GO:0060291)3.08941160
95regulation of gamma-delta T cell activation (GO:0046643)3.08836317
96positive regulation of mast cell activation (GO:0033005)3.08236804
97detection of other organism (GO:0098543)3.07137798
98granulocyte activation (GO:0036230)3.06993027
99positive regulation of neurotransmitter secretion (GO:0001956)3.05752565
100positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.05302051
101regulation of regulated secretory pathway (GO:1903305)3.05183621
102regulation of mast cell activation involved in immune response (GO:0033006)3.04137455
103regulation of voltage-gated calcium channel activity (GO:1901385)3.04101710
104positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.02631965
105response to auditory stimulus (GO:0010996)3.02273507
106clathrin coat assembly (GO:0048268)3.01557049
107regulation of neurotransmitter transport (GO:0051588)3.00914468
108positive regulation of dendritic spine development (GO:0060999)3.00361621
109detection of bacterium (GO:0016045)2.99741533
110neuromuscular process controlling posture (GO:0050884)2.99700490
111positive regulation of synaptic transmission, GABAergic (GO:0032230)2.97338006
112positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.97289629
113regulation of synaptic transmission, glutamatergic (GO:0051966)2.95228645
114axonal fasciculation (GO:0007413)2.94971490
115neuronal ion channel clustering (GO:0045161)2.94223169
116leukocyte aggregation (GO:0070486)2.93868737
117lipopolysaccharide-mediated signaling pathway (GO:0031663)2.92727230
118positive regulation of neurotransmitter transport (GO:0051590)2.91882134
119prepulse inhibition (GO:0060134)2.91825911
120membrane hyperpolarization (GO:0060081)2.91558295
121axon cargo transport (GO:0008088)2.90989092
122membrane depolarization (GO:0051899)2.90901434
123presynaptic membrane organization (GO:0097090)2.89119057
124regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.88936008
125signal complex assembly (GO:0007172)2.88512908
126cell migration in hindbrain (GO:0021535)2.86872609
127regulation of B cell receptor signaling pathway (GO:0050855)2.86800752
128mating behavior (GO:0007617)2.85106507
129postsynaptic membrane organization (GO:0001941)2.85095379
130learning (GO:0007612)2.84939172
131negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.84783015
132neuromuscular process (GO:0050905)2.84770866
133response to muramyl dipeptide (GO:0032495)2.84642674
134presynaptic membrane assembly (GO:0097105)2.84167682
135mitochondrion transport along microtubule (GO:0047497)2.83579041
136establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.83579041
137long-chain fatty acid biosynthetic process (GO:0042759)2.83522754
138dendritic spine organization (GO:0097061)2.83456616
139interferon-gamma-mediated signaling pathway (GO:0060333)2.81187961
140immunoglobulin mediated immune response (GO:0016064)2.80062045
141detection of molecule of bacterial origin (GO:0032490)2.77932795
142detection of external biotic stimulus (GO:0098581)2.76126216
143response to acidic pH (GO:0010447)2.67543407
144positive regulation of CREB transcription factor activity (GO:0032793)2.65734726
145positive regulation of regulated secretory pathway (GO:1903307)2.65499256
146regulation of gamma-delta T cell differentiation (GO:0045586)2.64106461
147positive regulation of Rap GTPase activity (GO:0032854)2.63298535
148positive regulation of type 2 immune response (GO:0002830)2.61990215
149positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.58646179
150response to type I interferon (GO:0034340)2.56453933
151positive regulation of leukocyte degranulation (GO:0043302)2.55920489
152positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.55702064
153myeloid cell activation involved in immune response (GO:0002275)2.55557249
154cellular response to type I interferon (GO:0071357)2.55418112
155type I interferon signaling pathway (GO:0060337)2.55418112
156regulation of mast cell activation (GO:0033003)2.53382184
157* regulation of ARF GTPase activity (GO:0032312)2.49639794
158positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.49620677
159amino acid import (GO:0043090)2.49045357
160negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.49045003
161peptidyl-tyrosine autophosphorylation (GO:0038083)2.48630251
162regulation of podosome assembly (GO:0071801)2.48339255
163activation of MAPKKK activity (GO:0000185)2.47806205
164regulation of T cell tolerance induction (GO:0002664)2.45774322
165positive regulation of Cdc42 GTPase activity (GO:0043089)2.44795699
166germinal center formation (GO:0002467)2.44776295
167negative regulation of toll-like receptor signaling pathway (GO:0034122)2.44101816
168negative regulation of leukocyte mediated immunity (GO:0002704)2.43291215
169macrophage activation (GO:0042116)2.42918569
170regulation of interferon-beta biosynthetic process (GO:0045357)2.40618248
171cerebellar granule cell differentiation (GO:0021707)2.39845958
172cytoskeletal anchoring at plasma membrane (GO:0007016)2.38468971
173detection of biotic stimulus (GO:0009595)2.37502267
174negative regulation of lymphocyte mediated immunity (GO:0002707)2.35636269
175regulation of synapse maturation (GO:0090128)2.29908850
176regulation of female gonad development (GO:2000194)2.28704897
177regulation of tolerance induction (GO:0002643)2.26565041
178respiratory burst (GO:0045730)2.24851519
179cell-cell junction maintenance (GO:0045217)2.21835855

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.38894832
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.05126316
3RARB_27405468_Chip-Seq_BRAIN_Mouse3.03464797
4GBX2_23144817_ChIP-Seq_PC3_Human2.92432460
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.90929694
6REST_21632747_ChIP-Seq_MESCs_Mouse2.88753147
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.83121149
8DROSHA_22980978_ChIP-Seq_HELA_Human2.80637291
9SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.61526451
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.61339061
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57841247
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55093523
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55093523
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.49768922
15REST_18959480_ChIP-ChIP_MESCs_Mouse2.45275378
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44445500
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42432338
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.41582770
19* VDR_21846776_ChIP-Seq_THP-1_Human2.38335680
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.37350651
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28502593
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28066110
23IRF8_22096565_ChIP-ChIP_GC-B_Human2.27232912
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.22396886
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.19227570
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.13125286
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.11112252
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.98605672
29AR_21572438_ChIP-Seq_LNCaP_Human1.91242491
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.89459852
31* VDR_24763502_ChIP-Seq_THP-1_Human1.88107546
32* TCF7_22412390_ChIP-Seq_EML_Mouse1.86958665
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86243510
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.84880198
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83868620
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.74917928
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71975958
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.71512318
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.68983189
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.68438578
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.67566582
42* SPI1_23127762_ChIP-Seq_K562_Human1.66543005
43MYC_22102868_ChIP-Seq_BL_Human1.62546161
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.61500877
45SMC4_20622854_ChIP-Seq_HELA_Human1.59957712
46* P68_20966046_ChIP-Seq_HELA_Human1.58716494
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.57346850
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.55566355
49RACK7_27058665_Chip-Seq_MCF-7_Human1.54493472
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54402410
51KDM2B_26808549_Chip-Seq_K562_Human1.53858159
52IRF8_27001747_Chip-Seq_BMDM_Mouse1.53237646
53SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52463970
54STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.52286500
55* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.50530964
56RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.49630862
57SCL_19346495_ChIP-Seq_HPC-7_Human1.48202987
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.44174807
59* BCOR_27268052_Chip-Seq_Bcells_Human1.43396718
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.42167208
61* BCL6_27268052_Chip-Seq_Bcells_Human1.41903793
62GATA1_19941827_ChIP-Seq_MEL_Mouse1.40481073
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39861799
64MAF_26560356_Chip-Seq_TH1_Human1.36857636
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34533864
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34157107
67* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33349892
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33067935
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32907895
70SA1_27219007_Chip-Seq_ERYTHROID_Human1.32745148
71EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32672429
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32151143
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32030381
74RUNX1_22412390_ChIP-Seq_EML_Mouse1.31977760
75ELF1_20517297_ChIP-Seq_JURKAT_Human1.31196375
76SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31158798
77SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31059866
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.29337188
79KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27958818
80SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.27184932
81WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27166933
82WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26761348
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26478635
84CREB1_26743006_Chip-Seq_LNCaP_Human1.25870664
85MAF_26560356_Chip-Seq_TH2_Human1.24687287
86RING1B_27294783_Chip-Seq_ESCs_Mouse1.24654132
87NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23763980
88KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22886616
89SMAD4_21799915_ChIP-Seq_A2780_Human1.22777366
90UTX_26944678_Chip-Seq_JUKART_Human1.22486858
91TAF15_26573619_Chip-Seq_HEK293_Human1.21740668
92* OCT4_19829295_ChIP-Seq_ESCs_Human1.21586001
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20844248
94SOX2_21211035_ChIP-Seq_LN229_Gbm1.20379429
95NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20183956
96SA1_27219007_Chip-Seq_Bcells_Human1.18594862
97SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16764235
98SMAD_19615063_ChIP-ChIP_OVARY_Human1.16675125
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14838015
100ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14795396
101CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13951951
102VDR_24787735_ChIP-Seq_THP-1_Human1.12892223
103E2F1_20622854_ChIP-Seq_HELA_Human1.12872397
104THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12422564
105UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11769129
106CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11335737
107OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10138863
108GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09391535
109TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08746604
110BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08446691
111AR_19668381_ChIP-Seq_PC3_Human1.07422575
112PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07004383
113RING1B_27294783_Chip-Seq_NPCs_Mouse1.06789272
114PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06292926
115CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05819122
116* TET1_21451524_ChIP-Seq_MESCs_Mouse1.05147416
117RUNX_20019798_ChIP-Seq_JUKART_Human1.04535896
118PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04300420
119RUNX1_27514584_Chip-Seq_MCF-7_Human1.03829866
120SMAD3_21741376_ChIP-Seq_EPCs_Human1.03471155
121* STAT3_23295773_ChIP-Seq_U87_Human1.02919928
122PHF8_20622854_ChIP-Seq_HELA_Human1.02364309
123SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02191258
124VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02188508
125ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00875450
126* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00753361
127TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99968280
128TET1_21490601_ChIP-Seq_MESCs_Mouse0.99920481
129LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99187914
130STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98154206
131CTCF_20526341_ChIP-Seq_ESCs_Human0.98053886
132TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97772778
133TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96913222
134KDM2B_26808549_Chip-Seq_DND41_Human0.96597168
135* TP63_22573176_ChIP-Seq_HFKS_Human0.96446977
136AR_25329375_ChIP-Seq_VCAP_Human0.95733858
137MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95533775
138SMAD3_21741376_ChIP-Seq_ESCs_Human0.94991886
139JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.94785487
140PRDM14_20953172_ChIP-Seq_ESCs_Human0.93649412
141CTCF_27219007_Chip-Seq_Bcells_Human0.93622311
142AHR_22903824_ChIP-Seq_MCF-7_Human0.93225814
143MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92726000
144TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92507025
145TCF4_23295773_ChIP-Seq_U87_Human0.91375451
146ZNF274_21170338_ChIP-Seq_K562_Hela0.91306192
147ARNT_22903824_ChIP-Seq_MCF-7_Human0.90576449
148LXR_22292898_ChIP-Seq_THP-1_Human0.88166949
149P300_19829295_ChIP-Seq_ESCs_Human0.87067808
150NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86405232
151ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85564883
152YAP1_20516196_ChIP-Seq_MESCs_Mouse0.84733393
153SMAD3_21741376_ChIP-Seq_HESCs_Human0.84186855
154TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84112659
155IGF1R_20145208_ChIP-Seq_DFB_Human0.83380710
156RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83373211
157KDM2B_26808549_Chip-Seq_JURKAT_Human0.83139924
158ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82712795
159KLF4_19829295_ChIP-Seq_ESCs_Human0.82614984
160PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.82542947
161SMAD4_21741376_ChIP-Seq_HESCs_Human0.82537272
162* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82372108
163RXR_22108803_ChIP-Seq_LS180_Human0.80056899
164TP53_16413492_ChIP-PET_HCT116_Human0.79669007
165RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.78425600
166CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78364325

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.78395788
2MP0003880_abnormal_central_pattern4.84738838
3MP0004270_analgesia4.35889933
4MP0003635_abnormal_synaptic_transmissio4.12819052
5MP0009745_abnormal_behavioral_response3.30708041
6MP0002063_abnormal_learning/memory/cond3.28633479
7MP0002064_seizures3.26063791
8MP0003436_decreased_susceptibility_to3.13395328
9MP0009046_muscle_twitch3.05802405
10MP0001968_abnormal_touch/_nociception3.05337465
11MP0005423_abnormal_somatic_nervous2.96023373
12MP0006082_CNS_inflammation2.86391648
13MP0002734_abnormal_mechanical_nocicepti2.81559288
14MP0002822_catalepsy2.70057803
15MP0003329_amyloid_beta_deposits2.68755681
16MP0002272_abnormal_nervous_system2.66579929
17MP0002572_abnormal_emotion/affect_behav2.66129738
18MP0001486_abnormal_startle_reflex2.60391418
19MP0002735_abnormal_chemical_nociception2.46008396
20MP0003724_increased_susceptibility_to2.39088801
21MP0002736_abnormal_nociception_after2.37676623
22MP0002733_abnormal_thermal_nociception2.35906800
23MP0004858_abnormal_nervous_system2.25878395
24MP0001970_abnormal_pain_threshold2.23473614
25MP0001835_abnormal_antigen_presentation2.22130885
26MP0005025_abnormal_response_to2.16351011
27MP0005671_abnormal_response_to2.10741705
28MP0002419_abnormal_innate_immunity2.07240874
29MP0001501_abnormal_sleep_pattern2.07202098
30MP0001440_abnormal_grooming_behavior2.05404753
31MP0000920_abnormal_myelination2.04619097
32MP0005000_abnormal_immune_tolerance2.00368391
33MP0008569_lethality_at_weaning1.93157575
34MP0000778_abnormal_nervous_system1.91507099
35MP0009785_altered_susceptibility_to1.90983779
36MP0002148_abnormal_hypersensitivity_rea1.90188503
37MP0004811_abnormal_neuron_physiology1.90093520
38MP0001790_abnormal_immune_system1.89379289
39MP0005387_immune_system_phenotype1.89379289
40MP0001800_abnormal_humoral_immune1.85664048
41MP0002067_abnormal_sensory_capabilities1.83135874
42MP0009278_abnormal_bone_marrow1.82537347
43MP0009780_abnormal_chondrocyte_physiolo1.74662766
44MP0002723_abnormal_immune_serum1.74434156
45MP0000604_amyloidosis1.72431968
46MP0000955_abnormal_spinal_cord1.71403483
47MP0004924_abnormal_behavior1.71079468
48MP0005386_behavior/neurological_phenoty1.71079468
49MP0004885_abnormal_endolymph1.69021835
50MP0005451_abnormal_body_composition1.68937311
51MP0002452_abnormal_antigen_presenting1.66454716
52MP0003633_abnormal_nervous_system1.63631254
53MP0003191_abnormal_cellular_cholesterol1.62565621
54MP0002420_abnormal_adaptive_immunity1.60809046
55MP0002184_abnormal_innervation1.60520274
56MP0001819_abnormal_immune_cell1.59872239
57MP0010155_abnormal_intestine_physiology1.56121781
58MP0000685_abnormal_immune_system1.53930143
59MP0004947_skin_inflammation1.53870593
60MP0003690_abnormal_glial_cell1.53250828
61MP0003866_abnormal_defecation1.51975165
62MP0001533_abnormal_skeleton_physiology1.50045891
63MP0002066_abnormal_motor_capabilities/c1.49922129
64MP0002557_abnormal_social/conspecific_i1.49494881
65MP0003879_abnormal_hair_cell1.46801981
66MP0002882_abnormal_neuron_morphology1.44989407
67MP0003631_nervous_system_phenotype1.43350433
68MP0001905_abnormal_dopamine_level1.41192185
69MP0003075_altered_response_to1.39987850
70MP0008260_abnormal_autophagy1.39411564
71MP0004142_abnormal_muscle_tone1.39186942
72MP0004510_myositis1.38673045
73MP0002909_abnormal_adrenal_gland1.34937104
74MP0003172_abnormal_lysosome_physiology1.34884644
75MP0003634_abnormal_glial_cell1.32846267
76MP0003303_peritoneal_inflammation1.28292651
77MP0001529_abnormal_vocalization1.27986905
78MP0009840_abnormal_foam_cell1.27498449
79MP0003300_gastrointestinal_ulcer1.26102935
80MP0002998_abnormal_bone_remodeling1.25690403
81MP0002229_neurodegeneration1.21178627
82MP0004742_abnormal_vestibular_system1.19986079
83MP0009764_decreased_sensitivity_to1.19917008
84MP0001845_abnormal_inflammatory_respons1.17612551
85MP0003045_fibrosis1.17024865
86MP0003632_abnormal_nervous_system1.16422511
87MP0001348_abnormal_lacrimal_gland1.16155185
88MP0002405_respiratory_system_inflammati1.12848115
89MP0000716_abnormal_immune_system1.12124435
90MP0001765_abnormal_ion_homeostasis1.09464619
91MP0008872_abnormal_physiological_respon1.08241449
92MP0000569_abnormal_digit_pigmentation1.08205571
93MP0005377_hearing/vestibular/ear_phenot1.07995524
94MP0003878_abnormal_ear_physiology1.07995524
95MP0006276_abnormal_autonomic_nervous1.07148134
96MP0008874_decreased_physiological_sensi1.06807386
97MP0005397_hematopoietic_system_phenotyp1.06691638
98MP0001545_abnormal_hematopoietic_system1.06691638
99MP0005076_abnormal_cell_differentiation1.06494634
100MP0002152_abnormal_brain_morphology1.05704840
101MP0008004_abnormal_stomach_pH1.02890478
102MP0005670_abnormal_white_adipose1.02455071
103MP0003787_abnormal_imprinting1.01892428
104MP0002398_abnormal_bone_marrow0.97985619
105MP0001502_abnormal_circadian_rhythm0.97522835
106MP0009333_abnormal_splenocyte_physiolog0.95714691
107MP0005464_abnormal_platelet_physiology0.95517666
108MP0008469_abnormal_protein_level0.91019331
109MP0001984_abnormal_olfaction0.90472249
110MP0005645_abnormal_hypothalamus_physiol0.90307792
111MP0000678_abnormal_parathyroid_gland0.89480166
112MP0001873_stomach_inflammation0.88184387
113MP0005167_abnormal_blood-brain_barrier0.86502879
114MP0003763_abnormal_thymus_physiology0.86362269
115MP0005646_abnormal_pituitary_gland0.85338406
116MP0000858_altered_metastatic_potential0.83179583
117MP0002069_abnormal_eating/drinking_beha0.82305783
118MP0003705_abnormal_hypodermis_morpholog0.80681980
119MP0002429_abnormal_blood_cell0.77828318
120MP0003453_abnormal_keratinocyte_physiol0.77721801
121MP0001963_abnormal_hearing_physiology0.77642028
122MP0001485_abnormal_pinna_reflex0.76868813
123MP0005409_darkened_coat_color0.76278710
124MP0005535_abnormal_body_temperature0.75748388
125MP0001177_atelectasis0.72844793
126MP0003183_abnormal_peptide_metabolism0.72010225
127MP0002090_abnormal_vision0.67322217
128MP0005623_abnormal_meninges_morphology0.65789566
129MP0005310_abnormal_salivary_gland0.65251749
130MP0002752_abnormal_somatic_nervous0.64931777
131MP0005166_decreased_susceptibility_to0.64167708
132MP0008961_abnormal_basal_metabolism0.63343171
133MP0001664_abnormal_digestion0.57192887
134MP0003283_abnormal_digestive_organ0.56649444
135MP0010234_abnormal_vibrissa_follicle0.55656854
136MP0005394_taste/olfaction_phenotype0.55086692
137MP0005499_abnormal_olfactory_system0.55086692
138MP0005058_abnormal_lysosome_morphology0.54323978
139MP0000751_myopathy0.51282499
140MP0000747_muscle_weakness0.50651242
141MP0004145_abnormal_muscle_electrophysio0.50632860
142MP0005410_abnormal_fertilization0.50448077
143MP0004085_abnormal_heartbeat0.50360823
144MP0001943_abnormal_respiration0.48123429
145MP0010769_abnormal_survival0.47200691
146MP0005551_abnormal_eye_electrophysiolog0.47132023
147MP0003956_abnormal_body_size0.46430713
148MP0003861_abnormal_nervous_system0.45158066
149MP0004043_abnormal_pH_regulation0.43809743
150MP0000015_abnormal_ear_pigmentation0.43479123
151MP0010386_abnormal_urinary_bladder0.43262739
152MP0010768_mortality/aging0.43243680
153MP0010770_preweaning_lethality0.43207976

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.19847058
2Focal motor seizures (HP:0011153)6.12000254
3Supranuclear gaze palsy (HP:0000605)5.22723466
4Visual hallucinations (HP:0002367)5.04433615
5Focal seizures (HP:0007359)5.02693733
6Increased cerebral lipofuscin (HP:0011813)4.94474228
7Increased neuronal autofluorescent lipopigment (HP:0002074)4.68461299
8Neurofibrillary tangles (HP:0002185)4.48828384
9Ankle clonus (HP:0011448)4.34309302
10Eczematoid dermatitis (HP:0000976)4.26457092
11Epileptic encephalopathy (HP:0200134)4.23669988
12Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.15292402
13Action tremor (HP:0002345)4.08737248
14Cerebral inclusion bodies (HP:0100314)4.04021055
15Abnormality of macrophages (HP:0004311)3.96527867
16Recurrent bacterial skin infections (HP:0005406)3.92386239
17Mutism (HP:0002300)3.88937862
18Recurrent abscess formation (HP:0002722)3.83599329
19Atonic seizures (HP:0010819)3.79871413
20Abnormality of the corticospinal tract (HP:0002492)3.78649749
21Progressive cerebellar ataxia (HP:0002073)3.72091012
22Papilledema (HP:0001085)3.61779721
23Spastic gait (HP:0002064)3.50288910
24Dysmetria (HP:0001310)3.48066615
25Insidious onset (HP:0003587)3.47795106
26Termporal pattern (HP:0011008)3.47795106
27Urinary bladder sphincter dysfunction (HP:0002839)3.43955625
28Absence seizures (HP:0002121)3.35751143
29Urinary urgency (HP:0000012)3.34685246
30Autoimmune thrombocytopenia (HP:0001973)3.31298511
31Generalized tonic-clonic seizures (HP:0002069)3.29903372
32Febrile seizures (HP:0002373)3.24021064
33Broad-based gait (HP:0002136)3.23659934
34Dialeptic seizures (HP:0011146)3.22574413
35Recurrent gram-negative bacterial infections (HP:0005420)3.22331218
36Poor eye contact (HP:0000817)3.21431544
37Degeneration of the lateral corticospinal tracts (HP:0002314)3.11254657
38Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.11254657
39Impaired vibration sensation in the lower limbs (HP:0002166)3.11123426
40Intention tremor (HP:0002080)3.11093298
41Myositis (HP:0100614)3.08913834
42Postural instability (HP:0002172)3.08227627
43Diplopia (HP:0000651)3.04387026
44Abnormality of binocular vision (HP:0011514)3.04387026
45Orchitis (HP:0100796)3.02533285
46Abnormal eating behavior (HP:0100738)2.97246575
47Abnormality of glycolipid metabolism (HP:0010969)2.96632963
48Abnormality of liposaccharide metabolism (HP:0010968)2.96632963
49Abnormality of glycosphingolipid metabolism (HP:0004343)2.96632963
50Depression (HP:0000716)2.94860735
51Impaired social interactions (HP:0000735)2.92827953
52Abnormal social behavior (HP:0012433)2.92827953
53Gaze-evoked nystagmus (HP:0000640)2.92170255
54Dysdiadochokinesis (HP:0002075)2.89390573
55Retrobulbar optic neuritis (HP:0100654)2.86926851
56Optic neuritis (HP:0100653)2.86926851
57Dysmetric saccades (HP:0000641)2.85542054
58Truncal ataxia (HP:0002078)2.83942390
59Akinesia (HP:0002304)2.80156436
60Loss of speech (HP:0002371)2.77998840
61Progressive inability to walk (HP:0002505)2.72893257
62Chronic obstructive pulmonary disease (HP:0006510)2.72625153
63Obstructive lung disease (HP:0006536)2.72625153
64Increased IgE level (HP:0003212)2.71300739
65Amyotrophic lateral sclerosis (HP:0007354)2.67909835
66Gingivitis (HP:0000230)2.67656084
67Dysostosis multiplex (HP:0000943)2.67468648
68Apathy (HP:0000741)2.66856631
69Scanning speech (HP:0002168)2.64188954
70Neuronal loss in central nervous system (HP:0002529)2.63087391
71Lower limb muscle weakness (HP:0007340)2.62566117
72Stomatitis (HP:0010280)2.62414668
73Anxiety (HP:0000739)2.62411630
74Peripheral hypomyelination (HP:0007182)2.59734741
75Mediastinal lymphadenopathy (HP:0100721)2.58001245
76Torticollis (HP:0000473)2.57716946
77Megalencephaly (HP:0001355)2.53645746
78Limb dystonia (HP:0002451)2.53260742
79Hyperventilation (HP:0002883)2.49736599
80Amblyopia (HP:0000646)2.49400991
81Onion bulb formation (HP:0003383)2.47310130
82Axonal loss (HP:0003447)2.47234020
83Bradykinesia (HP:0002067)2.47020797
84Pheochromocytoma (HP:0002666)2.45883611
85Dementia (HP:0000726)2.45495154
86Amyloidosis (HP:0011034)2.44934506
87Stereotypic behavior (HP:0000733)2.42579492
88Hemiparesis (HP:0001269)2.42214841
89Recurrent skin infections (HP:0001581)2.41852600
90Gastrointestinal inflammation (HP:0004386)2.41758409
91Impaired smooth pursuit (HP:0007772)2.41599998
92Cellulitis (HP:0100658)2.41304867
93Inappropriate behavior (HP:0000719)2.40900172
94Inflammation of the large intestine (HP:0002037)2.40261040
95Systemic lupus erythematosus (HP:0002725)2.39079099
96Spastic tetraparesis (HP:0001285)2.39042142
97Abnormality of the lower motor neuron (HP:0002366)2.38826428
98Diminished motivation (HP:0000745)2.36397192
99Clonus (HP:0002169)2.35812170
100Focal dystonia (HP:0004373)2.35231113
101Meningitis (HP:0001287)2.34692399
102Drooling (HP:0002307)2.34056176
103Excessive salivation (HP:0003781)2.34056176
104Genetic anticipation (HP:0003743)2.32796225
105Elevated erythrocyte sedimentation rate (HP:0003565)2.31132227
106Generalized myoclonic seizures (HP:0002123)2.29796643
107Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.29017945
108Recurrent fungal infections (HP:0002841)2.25409161
109Insomnia (HP:0100785)2.22429807
110Abnormality of the periventricular white matter (HP:0002518)2.21030505
111Malnutrition (HP:0004395)2.19113633
112Hemiplegia (HP:0002301)2.19108067
113Hemorrhage of the eye (HP:0011885)2.18541633
114Polyphagia (HP:0002591)2.17746072
115Rigidity (HP:0002063)2.16998532
116Craniofacial dystonia (HP:0012179)2.15633481
117Rapidly progressive (HP:0003678)2.15280833
118Disinhibition (HP:0000734)2.14775001
119Annular pancreas (HP:0001734)2.14708006
120Abnormality of saccadic eye movements (HP:0000570)2.13867198
121Absent speech (HP:0001344)2.12530685
122Lower limb amyotrophy (HP:0007210)2.11389480
123Abnormality of polysaccharide metabolism (HP:0011012)2.10992055
124Abnormality of glycosaminoglycan metabolism (HP:0004371)2.10992055
125Abnormality of mucopolysaccharide metabolism (HP:0011020)2.10992055
126Obstructive sleep apnea (HP:0002870)2.08795603
127Morphological abnormality of the pyramidal tract (HP:0002062)2.06259204
128Urinary glycosaminoglycan excretion (HP:0003541)2.05840849
129Mucopolysacchariduria (HP:0008155)2.05840849
130Gastrointestinal infarctions (HP:0005244)2.05796523
131Abnormality of ocular smooth pursuit (HP:0000617)2.05634507
132Abnormality of the fingertips (HP:0001211)2.04282708
133Slow saccadic eye movements (HP:0000514)2.04060723
134Impaired vibratory sensation (HP:0002495)2.04027577
135Neuroendocrine neoplasm (HP:0100634)2.03620570
136Vasculitis (HP:0002633)2.03396987
137Colitis (HP:0002583)2.01212157
138Inability to walk (HP:0002540)1.99723759
139Psychosis (HP:0000709)1.99654146
140Epileptiform EEG discharges (HP:0011182)1.96481047
141Delusions (HP:0000746)1.95930733
142Vacuolated lymphocytes (HP:0001922)1.95790359
143Ventricular fibrillation (HP:0001663)1.94551069
144Keratoconjunctivitis sicca (HP:0001097)1.94067866
145EEG with generalized epileptiform discharges (HP:0011198)1.92534394
146Hammertoe (HP:0001765)1.92101328
147Clumsiness (HP:0002312)1.92064075
148Retinal dysplasia (HP:0007973)1.90963442
149Progressive visual loss (HP:0000529)1.90606552
150Gait ataxia (HP:0002066)1.90067584
151Resting tremor (HP:0002322)1.89490275
152Fetal akinesia sequence (HP:0001989)1.88844528
153Memory impairment (HP:0002354)1.88584627
154Cerebral aneurysm (HP:0004944)1.87836958
155Hypsarrhythmia (HP:0002521)1.87760102
156Urticaria (HP:0001025)1.84982818
157Hemoptysis (HP:0002105)1.80591775
158Personality changes (HP:0000751)1.80239024
159Dysautonomia (HP:0002459)1.79851372
160Pustule (HP:0200039)1.77890336
161Encephalitis (HP:0002383)1.77237524
162Keratoconjunctivitis (HP:0001096)1.76609622
163Episodic fever (HP:0001954)1.75596378
164Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.74606686

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.26953532
2MARK13.71819241
3EPHA43.70993983
4NTRK33.33144727
5TRIB32.81095850
6DAPK22.74928640
7MINK12.61442771
8PAK62.56661901
9KSR22.54665062
10MAP4K12.46674630
11MAP3K42.45299908
12SIK12.34662333
13NTRK12.27922479
14IRAK32.26372845
15RIPK42.22418967
16MAP2K71.95982485
17ERN11.93684118
18CAMKK11.90465874
19MAP3K111.88679221
20PRKD31.86232941
21NTRK21.84824220
22BLK1.82769431
23CDK191.66740125
24CDK51.65435958
25DDR21.62142032
26IRAK41.61859029
27MAP3K131.56349153
28MAP2K41.52234194
29MAP3K121.47173682
30TYK21.47051558
31DAPK11.46600037
32FES1.46538873
33GRK51.44364473
34OXSR11.43740593
35SIK31.42976169
36PRPF4B1.39710071
37CSK1.39305249
38TAOK21.37453554
39MST1R1.34440090
40SIK21.32795709
41TYRO31.30622030
42UHMK11.29375058
43MAP3K21.29098287
44ARAF1.26213351
45STK391.21962715
46CASK1.20165047
47MAP2K31.20119789
48IRAK21.18987256
49PHKG21.17998325
50PHKG11.17998325
51KSR11.16144119
52PNCK1.13991098
53TNIK1.13666194
54TBK11.13492576
55ALK1.10978944
56PKN11.09625697
57MAPK131.09376338
58PLK21.09227402
59FGR1.08342841
60ZAP701.07890349
61RET1.06446563
62TAOK11.04400413
63CDK151.04337586
64CAMK1D1.03195946
65CDK141.02503846
66CDK181.01719000
67STK111.00817677
68MAP3K30.99137029
69MATK0.98957203
70SMG10.96271503
71BTK0.95959730
72ACVR1B0.94368338
73CDC42BPA0.93545064
74CAMKK20.93390162
75CDK11A0.91883750
76MARK20.89397317
77PRKCG0.89125563
78PRKG20.89014435
79SYK0.88998396
80MARK30.88888023
81LIMK10.88857914
82PRKD20.88745978
83CSNK1G20.88705284
84JAK10.87684722
85HCK0.87234717
86MAPKAPK50.87118824
87CSF1R0.83941347
88STK380.81756583
89SGK4940.80691302
90SGK2230.80691302
91PDPK10.80598933
92PDK10.80442315
93TESK10.79080986
94RAF10.78602128
95IKBKE0.77819965
96WNK10.77736435
97PRKCH0.76954862
98CAMK2A0.76112476
99EPHA20.76083487
100CAMK2B0.75546097
101LATS20.74799407
102MAP2K60.72310732
103DAPK30.71087711
104CAMK10.69602979
105SCYL20.69135176
106MAP3K140.67146556
107TXK0.66985099
108RIPK10.66146412
109JAK20.64712366
110FYN0.64501352
111MAP3K10.63959035
112LMTK20.63845245
113PAK30.62676444
114LYN0.60812247
115HIPK20.58094261
116IKBKB0.56847530
117SGK10.55706978
118JAK30.55526627
119PRKCZ0.55385449
120CAMK1G0.54721588
121CDK120.54057694
122ICK0.53697251
123LCK0.53461591
124PTK60.53227514
125PTK2B0.52965640
126KIT0.52130543
127ROCK20.51726721
128EPHB10.47643608
129TNK20.47468542
130TESK20.46777865
131DYRK1A0.46014224
132CSNK1G30.45329071
133MAP3K70.45271437
134ITK0.45017479
135BMPR20.44076402
136TAOK30.43967637
137PKN20.43684562
138DYRK20.42494683
139BMX0.42378671
140CAMK40.42081028
141CAMK2G0.41457546
142MAPK100.41321031
143RPS6KC10.40673557
144RPS6KL10.40673557
145RPS6KA30.40156787
146CAMK2D0.39757534
147RPS6KA60.39050130
148MAP3K60.38263914
149GRK60.37864012
150PINK10.37752249
151MAPK120.33841662
152CSNK1A1L0.33232574
153RPS6KA20.33192667
154SGK30.29867185

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.27135204
2Nicotine addiction_Homo sapiens_hsa050332.85092762
3Olfactory transduction_Homo sapiens_hsa047402.60953097
4Glutamatergic synapse_Homo sapiens_hsa047242.47928215
5Circadian entrainment_Homo sapiens_hsa047132.45343080
6Long-term potentiation_Homo sapiens_hsa047202.45011561
7GABAergic synapse_Homo sapiens_hsa047272.42831456
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.37786436
9Morphine addiction_Homo sapiens_hsa050322.33154242
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.31482009
11Salivary secretion_Homo sapiens_hsa049702.06995466
12Osteoclast differentiation_Homo sapiens_hsa043802.04649248
13Dopaminergic synapse_Homo sapiens_hsa047282.04578547
14Amphetamine addiction_Homo sapiens_hsa050312.02210399
15Leishmaniasis_Homo sapiens_hsa051402.00426533
16Other glycan degradation_Homo sapiens_hsa005111.92898655
17Gastric acid secretion_Homo sapiens_hsa049711.91232381
18Cholinergic synapse_Homo sapiens_hsa047251.87813228
19Long-term depression_Homo sapiens_hsa047301.77624077
20Graft-versus-host disease_Homo sapiens_hsa053321.71337212
21Allograft rejection_Homo sapiens_hsa053301.68611903
22Staphylococcus aureus infection_Homo sapiens_hsa051501.67729690
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.64300145
24Renin secretion_Homo sapiens_hsa049241.58254050
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57724970
26Insulin secretion_Homo sapiens_hsa049111.57331778
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57066770
28Serotonergic synapse_Homo sapiens_hsa047261.56201458
29Oxytocin signaling pathway_Homo sapiens_hsa049211.53680953
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53481644
31Autoimmune thyroid disease_Homo sapiens_hsa053201.45104474
32Cocaine addiction_Homo sapiens_hsa050301.44415078
33GnRH signaling pathway_Homo sapiens_hsa049121.44009964
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.41397425
35Gap junction_Homo sapiens_hsa045401.41052709
36Collecting duct acid secretion_Homo sapiens_hsa049661.40642850
37Asthma_Homo sapiens_hsa053101.33454540
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.32832917
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32660659
40Taste transduction_Homo sapiens_hsa047421.30227753
41Axon guidance_Homo sapiens_hsa043601.27179241
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.26444882
43Calcium signaling pathway_Homo sapiens_hsa040201.25955900
44Glioma_Homo sapiens_hsa052141.22168584
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19181965
46Estrogen signaling pathway_Homo sapiens_hsa049151.18008277
47ErbB signaling pathway_Homo sapiens_hsa040121.17799735
48Type II diabetes mellitus_Homo sapiens_hsa049301.16536286
49Nitrogen metabolism_Homo sapiens_hsa009101.15994073
50NF-kappa B signaling pathway_Homo sapiens_hsa040641.14511812
51cAMP signaling pathway_Homo sapiens_hsa040241.12534838
52NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11237362
53TNF signaling pathway_Homo sapiens_hsa046681.07639549
54Phospholipase D signaling pathway_Homo sapiens_hsa040721.06035276
55Toxoplasmosis_Homo sapiens_hsa051451.02640626
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99397626
57Sphingolipid signaling pathway_Homo sapiens_hsa040710.98123426
58Dorso-ventral axis formation_Homo sapiens_hsa043200.96221983
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95540345
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95185124
61Pertussis_Homo sapiens_hsa051330.94909258
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94891894
63VEGF signaling pathway_Homo sapiens_hsa043700.94754329
64Influenza A_Homo sapiens_hsa051640.94432098
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93418336
66Acute myeloid leukemia_Homo sapiens_hsa052210.93351487
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92998758
68T cell receptor signaling pathway_Homo sapiens_hsa046600.92334864
69Vibrio cholerae infection_Homo sapiens_hsa051100.91146248
70Malaria_Homo sapiens_hsa051440.90160679
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.90050806
72Antigen processing and presentation_Homo sapiens_hsa046120.89448142
73Endocytosis_Homo sapiens_hsa041440.87081869
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.85604005
75Notch signaling pathway_Homo sapiens_hsa043300.85208051
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85019673
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84265740
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83981864
79Choline metabolism in cancer_Homo sapiens_hsa052310.83739150
80Melanogenesis_Homo sapiens_hsa049160.83233809
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81498952
82MAPK signaling pathway_Homo sapiens_hsa040100.80912781
83Renal cell carcinoma_Homo sapiens_hsa052110.80389458
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79809533
85Chemokine signaling pathway_Homo sapiens_hsa040620.79577892
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.78148617
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77991824
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.76188149
89Hepatitis C_Homo sapiens_hsa051600.75883986
90Viral myocarditis_Homo sapiens_hsa054160.74772535
91Oocyte meiosis_Homo sapiens_hsa041140.74494091
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73758505
93Pancreatic secretion_Homo sapiens_hsa049720.72321390
94Ras signaling pathway_Homo sapiens_hsa040140.70345288
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66440125
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66205380
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.65816985
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.64753923
99Cardiac muscle contraction_Homo sapiens_hsa042600.62208592
100Thyroid hormone synthesis_Homo sapiens_hsa049180.61488216
101Hematopoietic cell lineage_Homo sapiens_hsa046400.60098639
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58686129
103Legionellosis_Homo sapiens_hsa051340.58313650
104Rap1 signaling pathway_Homo sapiens_hsa040150.58233623
105Prolactin signaling pathway_Homo sapiens_hsa049170.58220649
106Non-small cell lung cancer_Homo sapiens_hsa052230.57500362
107Chronic myeloid leukemia_Homo sapiens_hsa052200.56889932
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56752804
109Herpes simplex infection_Homo sapiens_hsa051680.56563377
110Inositol phosphate metabolism_Homo sapiens_hsa005620.54760496
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54290902
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54005194
113Measles_Homo sapiens_hsa051620.53967242
114B cell receptor signaling pathway_Homo sapiens_hsa046620.53219219
115Salmonella infection_Homo sapiens_hsa051320.52948875
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50239773
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48848898
118African trypanosomiasis_Homo sapiens_hsa051430.47420610
119Type I diabetes mellitus_Homo sapiens_hsa049400.46654969
120Endometrial cancer_Homo sapiens_hsa052130.46083229
121mTOR signaling pathway_Homo sapiens_hsa041500.45818619
122Prion diseases_Homo sapiens_hsa050200.45622199
123Alcoholism_Homo sapiens_hsa050340.45231640
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44283511
125Platelet activation_Homo sapiens_hsa046110.42724355
126Tuberculosis_Homo sapiens_hsa051520.41469653
127Ether lipid metabolism_Homo sapiens_hsa005650.41378407
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41158409
129Dilated cardiomyopathy_Homo sapiens_hsa054140.41101948
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40336414
131Phagosome_Homo sapiens_hsa041450.39676541
132Bile secretion_Homo sapiens_hsa049760.37625645
133Mineral absorption_Homo sapiens_hsa049780.37402993
134Lysosome_Homo sapiens_hsa041420.37132085
135Colorectal cancer_Homo sapiens_hsa052100.36044492
136Rheumatoid arthritis_Homo sapiens_hsa053230.35594554

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