ADAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene binds beta-tubulin and increases the stability of microtubules. The encoded protein can also translocate to the cell membrane and bind phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). In addition, this protein is a GTPase-activating protein for ADP ribosylation factor 6 and may be able to block the entry of some RNA viruses. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)4.71293075
2glycosphingolipid catabolic process (GO:0046479)4.57063773
3microglial cell activation (GO:0001774)4.54618199
4regulation of interferon-beta biosynthetic process (GO:0045357)4.53514184
5positive regulation of mast cell activation involved in immune response (GO:0033008)4.42783030
6positive regulation of mast cell degranulation (GO:0043306)4.42783030
7positive regulation of mast cell activation (GO:0033005)4.40190591
8positive regulation by symbiont of host defense response (GO:0052509)4.38687387
9modulation by symbiont of host defense response (GO:0052031)4.38687387
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.38687387
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.38687387
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.38687387
13modulation by symbiont of host immune response (GO:0052553)4.38687387
14cellular response to thyroid hormone stimulus (GO:0097067)4.31893246
15regulation of macrophage chemotaxis (GO:0010758)4.31443687
16amino sugar catabolic process (GO:0046348)4.25470169
17positive regulation of myeloid leukocyte mediated immunity (GO:0002888)4.23010232
18regulation of mast cell degranulation (GO:0043304)4.21303257
19positive regulation of gamma-delta T cell activation (GO:0046645)4.17471364
20macrophage activation involved in immune response (GO:0002281)4.16682534
21oligosaccharide catabolic process (GO:0009313)4.15252899
22positive regulation of interferon-alpha production (GO:0032727)4.15042201
23detection of molecule of bacterial origin (GO:0032490)4.14981228
24glycolipid catabolic process (GO:0019377)4.09129850
25proline metabolic process (GO:0006560)4.08379776
26regulation of mononuclear cell migration (GO:0071675)4.04574438
27regulation of mast cell activation involved in immune response (GO:0033006)3.95345220
28positive regulation of leukocyte degranulation (GO:0043302)3.92375432
29regulation of interferon-alpha production (GO:0032647)3.90146717
30detection of other organism (GO:0098543)3.89159571
31regulation of integrin activation (GO:0033623)3.82971806
32embryonic process involved in female pregnancy (GO:0060136)3.82155496
33N-acetylneuraminate metabolic process (GO:0006054)3.82031042
34sulfur amino acid catabolic process (GO:0000098)3.80624761
35regulation of myeloid leukocyte mediated immunity (GO:0002886)3.79733614
36triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.76976794
37complement activation, alternative pathway (GO:0006957)3.76103702
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.75151448
39cellular extravasation (GO:0045123)3.74171481
40regulation of mast cell activation (GO:0033003)3.73419677
41detection of external biotic stimulus (GO:0098581)3.73154805
42T-helper 1 type immune response (GO:0042088)3.70300196
43ceramide catabolic process (GO:0046514)3.66355786
44regulation of leukocyte degranulation (GO:0043300)3.65028910
45positive regulation of monocyte chemotaxis (GO:0090026)3.58503484
46positive regulation of protein homooligomerization (GO:0032464)3.57902544
47detection of bacterium (GO:0016045)3.54594926
48negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.49781871
49negative regulation of cell killing (GO:0031342)3.49781871
50negative regulation of granulocyte differentiation (GO:0030853)3.47647698
51positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.44213111
52regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.44163792
53response to thyroid hormone (GO:0097066)3.42859910
54lipopolysaccharide-mediated signaling pathway (GO:0031663)3.41440295
55granulocyte activation (GO:0036230)3.37979276
56positive regulation of interferon-beta production (GO:0032728)3.36558535
57detection of biotic stimulus (GO:0009595)3.36183256
58cholesterol efflux (GO:0033344)3.34644174
59myeloid cell activation involved in immune response (GO:0002275)3.32830673
60macrophage activation (GO:0042116)3.28644275
61phospholipid efflux (GO:0033700)3.27139692
62tryptophan metabolic process (GO:0006568)3.26815487
63peptidyl-glutamic acid carboxylation (GO:0017187)3.26368616
64protein carboxylation (GO:0018214)3.26368616
65regulation of antigen processing and presentation (GO:0002577)3.23976878
66G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.23612445
67indole-containing compound catabolic process (GO:0042436)3.23345476
68indolalkylamine catabolic process (GO:0046218)3.23345476
69tryptophan catabolic process (GO:0006569)3.23345476
70erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.23326662
71L-phenylalanine metabolic process (GO:0006558)3.23326662
72interferon-gamma-mediated signaling pathway (GO:0060333)3.21593255
73aromatic amino acid family catabolic process (GO:0009074)3.19105994
74histamine secretion (GO:0001821)3.17687101
75regulation of protein activation cascade (GO:2000257)3.15940914
76erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.14742298
77L-phenylalanine catabolic process (GO:0006559)3.14742298
78barbed-end actin filament capping (GO:0051016)3.14429986
79immunoglobulin mediated immune response (GO:0016064)3.13663278
80adenosine receptor signaling pathway (GO:0001973)3.12510112
81cellular response to ATP (GO:0071318)3.12318963
82B cell mediated immunity (GO:0019724)3.11074719
83plasma lipoprotein particle assembly (GO:0034377)3.10802561
84neutrophil activation (GO:0042119)3.10224394
85plasma lipoprotein particle clearance (GO:0034381)3.10208649
86very-low-density lipoprotein particle assembly (GO:0034379)3.09600614
87positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.07883608
88neutrophil activation involved in immune response (GO:0002283)3.07644657
89negative regulation of erythrocyte differentiation (GO:0045647)3.07627935
90urea cycle (GO:0000050)3.06790822
91urea metabolic process (GO:0019627)3.06790822
92regulation of complement activation (GO:0030449)3.06454810
93respiratory burst (GO:0045730)3.05872370
94alkaloid metabolic process (GO:0009820)3.05869280
95regulation of hypersensitivity (GO:0002883)3.04672761
96regulation of cholesterol storage (GO:0010885)3.04616889
97regulation of cholesterol esterification (GO:0010872)3.03627364
98phagocytosis, engulfment (GO:0006911)3.01847522
99membrane invagination (GO:0010324)3.01711297
100transcription from mitochondrial promoter (GO:0006390)3.01551986
101glutamine family amino acid biosynthetic process (GO:0009084)3.01012073
102regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.00370041
103glyoxylate metabolic process (GO:0046487)3.00226894
104negative regulation of fatty acid biosynthetic process (GO:0045717)2.99089987
105membrane lipid catabolic process (GO:0046466)2.97602495
106negative regulation of cytokine production involved in immune response (GO:0002719)2.97521275
107kynurenine metabolic process (GO:0070189)2.96911376
108regulation of gamma-delta T cell activation (GO:0046643)2.96441535
109phospholipid homeostasis (GO:0055091)2.95460211
110acylglycerol homeostasis (GO:0055090)2.94360305
111triglyceride homeostasis (GO:0070328)2.94360305
112positive regulation of cellular amide metabolic process (GO:0034250)2.94086995
113response to muramyl dipeptide (GO:0032495)2.93165830
114protein-lipid complex assembly (GO:0065005)2.92164274
115negative regulation of interleukin-12 production (GO:0032695)2.91686864
116fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.91350926
117embryonic placenta development (GO:0001892)2.89940773
118regulation of monocyte chemotaxis (GO:0090025)2.89642405
119phagosome maturation (GO:0090382)2.89488926
120response to peptidoglycan (GO:0032494)2.89149748
121sphingolipid catabolic process (GO:0030149)2.88148265
122macrophage differentiation (GO:0030225)2.86550789
123cytolysis (GO:0019835)2.85333869
124regulation of T cell tolerance induction (GO:0002664)2.85141411
125positive regulation of antigen processing and presentation (GO:0002579)2.84527688
126intestinal cholesterol absorption (GO:0030299)2.83146646
127regulation of regulated secretory pathway (GO:1903305)2.83127089
128myeloid dendritic cell differentiation (GO:0043011)2.83116503
129reverse cholesterol transport (GO:0043691)2.81866426
130hydrogen peroxide biosynthetic process (GO:0050665)2.81625140
131nitrogen cycle metabolic process (GO:0071941)2.81605249
132cellular response to zinc ion (GO:0071294)2.81378014
133negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.80866250
134monocyte chemotaxis (GO:0002548)2.80278002
135high-density lipoprotein particle remodeling (GO:0034375)2.80059096
136bile acid metabolic process (GO:0008206)2.79930270
137regulation of protein homooligomerization (GO:0032462)2.79500408
138homocysteine metabolic process (GO:0050667)2.77768770
139positive regulation of chemokine secretion (GO:0090197)2.76342546
140response to host immune response (GO:0052572)2.73261580
141response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.73261580
142negative regulation of interleukin-17 production (GO:0032700)2.73197528
143complement activation (GO:0006956)2.72476132
144myeloid dendritic cell activation (GO:0001773)2.71848997
145low-density lipoprotein particle remodeling (GO:0034374)2.71036947
146mannose metabolic process (GO:0006013)2.70754969
147germinal center formation (GO:0002467)2.69330147
148negative regulation of interleukin-1 beta production (GO:0032691)2.68215253
149production of molecular mediator involved in inflammatory response (GO:0002532)2.68152893
150positive regulation of regulated secretory pathway (GO:1903307)2.67364640
151positive regulation of type 2 immune response (GO:0002830)2.67228842
152NAD biosynthetic process (GO:0009435)2.67174136
153I-kappaB phosphorylation (GO:0007252)2.66695372
154bile acid biosynthetic process (GO:0006699)2.66628395
155positive regulation of B cell differentiation (GO:0045579)2.66411987
156complement activation, classical pathway (GO:0006958)2.66386508
157regulation of tolerance induction (GO:0002643)2.65892618
158apoptotic cell clearance (GO:0043277)2.65111714
159lytic vacuole organization (GO:0080171)2.64592942
160lysosome organization (GO:0007040)2.64592942
161regulation of dendritic cell antigen processing and presentation (GO:0002604)2.64342132
162positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.63661787
163bile acid and bile salt transport (GO:0015721)2.63489135
164cellular response to arsenic-containing substance (GO:0071243)2.62623352
165regulation of interferon-beta production (GO:0032648)2.61896127
166myeloid leukocyte activation (GO:0002274)2.61833962
167positive regulation of cholesterol efflux (GO:0010875)2.59768876
168positive regulation of toll-like receptor signaling pathway (GO:0034123)2.59327432
169lipoprotein metabolic process (GO:0042157)2.58176078
170regulation of triglyceride catabolic process (GO:0010896)2.57952380
171protein-lipid complex remodeling (GO:0034368)2.57047106
172macromolecular complex remodeling (GO:0034367)2.57047106
173plasma lipoprotein particle remodeling (GO:0034369)2.57047106
174regulation of interleukin-8 biosynthetic process (GO:0045414)2.55858874

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.68982166
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.56143582
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.54846937
4* RXR_22158963_ChIP-Seq_LIVER_Mouse4.12450114
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.59144187
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.49633839
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.38203548
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.05668925
9* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.98762678
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.95530224
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.73981641
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.71081419
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.64097868
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.52132824
15* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.44218288
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.38950818
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.22884871
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18591174
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.12848033
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.12545875
21CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.06596978
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.06483162
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.03528329
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.00182128
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.97344518
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.94187511
27KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.94187511
28KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.94187511
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.86262893
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.79457336
31VDR_21846776_ChIP-Seq_THP-1_Human1.78538286
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75033427
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.69660747
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.69450560
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.65811165
36PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.64566417
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58946814
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.55902435
39LXR_22292898_ChIP-Seq_THP-1_Human1.51992981
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.49947401
41* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.49129623
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.47168989
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45362285
44CDX2_20551321_ChIP-Seq_CACO-2_Human1.45013283
45SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44066926
46PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39315309
47GATA1_22025678_ChIP-Seq_K562_Human1.37922471
48* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35482811
49SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.33673573
50CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31770685
51VDR_24763502_ChIP-Seq_THP-1_Human1.31179756
52RXRA_24833708_ChIP-Seq_LIVER_Mouse1.30866261
53STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.30806970
54FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.30405864
55GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27460399
56STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.27011268
57* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26991387
58* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25992081
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25747340
60NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.24712225
61STAT1_20625510_ChIP-Seq_HELA_Human1.24092052
62* PU_27001747_Chip-Seq_BMDM_Mouse1.23803117
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.22327781
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21907700
65PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20948022
66* SPI1_23127762_ChIP-Seq_K562_Human1.20099307
67TFEB_21752829_ChIP-Seq_HELA_Human1.20032803
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.19813085
69MYB_26560356_Chip-Seq_TH2_Human1.15112424
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13679885
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13185954
72GATA1_19941826_ChIP-Seq_K562_Human1.13162499
73* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11745995
74TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.10454628
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09491750
76NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09296507
77SPI1_23547873_ChIP-Seq_NB4_Human1.09005076
78VDR_24787735_ChIP-Seq_THP-1_Human1.08122397
79NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08118188
80MAF_26560356_Chip-Seq_TH1_Human1.07521834
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07401887
82PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06768882
83ESR1_21235772_ChIP-Seq_MCF-7_Human1.06363932
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05942543
85BCL6_27268052_Chip-Seq_Bcells_Human1.05829337
86STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03793799
87RUNX1_22412390_ChIP-Seq_EML_Mouse1.03771130
88VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03415915
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03258889
90TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01877739
91ELK3_25401928_ChIP-Seq_HUVEC_Human1.01647201
92STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99778008
93GATA3_27048872_Chip-Seq_THYMUS_Human0.99189228
94BCOR_27268052_Chip-Seq_Bcells_Human0.98588399
95RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98452722
96UTX_26944678_Chip-Seq_JUKART_Human0.97845873
97GATA3_26560356_Chip-Seq_TH2_Human0.96762122
98NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.95543953
99TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94802185
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94550413
101SCL_19346495_ChIP-Seq_HPC-7_Human0.94532556
102GATA1_19941827_ChIP-Seq_MEL_Mouse0.91854960
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91794339
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89650246
105RACK7_27058665_Chip-Seq_MCF-7_Human0.89098633
106POU5F1_16518401_ChIP-PET_MESCs_Mouse0.89058071
107GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88921703
108TCF7_22412390_ChIP-Seq_EML_Mouse0.88314483
109SPI1_20517297_ChIP-Seq_HL60_Human0.88017086
110SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87846122
111SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.87021688
112KDM2B_26808549_Chip-Seq_DND41_Human0.86841197
113RARA_24833708_ChIP-Seq_LIVER_Mouse0.86771236
114GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86508822
115GATA2_19941826_ChIP-Seq_K562_Human0.86220209
116MAF_26560356_Chip-Seq_TH2_Human0.85792474
117RUNX_20019798_ChIP-Seq_JUKART_Human0.84842667
118* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84491331
119CTCF_21964334_ChIP-Seq_BJAB-B_Human0.84294531
120RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84013399
121MYB_26560356_Chip-Seq_TH1_Human0.83272555
122EGR1_19374776_ChIP-ChIP_THP-1_Human0.82583269
123SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82152775
124TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81791755
125STAT4_19710469_ChIP-ChIP_TH1__Mouse0.81511278
126KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.81489514
127ERG_21242973_ChIP-ChIP_JURKAT_Human0.80717569
128GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80652388
129* FOXA2_19822575_ChIP-Seq_HepG2_Human0.78977226
130ELF1_20517297_ChIP-Seq_JURKAT_Human0.77504527
131P63_26484246_Chip-Seq_KERATINOCYTES_Human0.73356862

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.80879639
2MP0005085_abnormal_gallbladder_physiolo3.64836844
3MP0003191_abnormal_cellular_cholesterol3.61752127
4MP0005360_urolithiasis3.48320257
5MP0002139_abnormal_hepatobiliary_system3.46520981
6MP0005365_abnormal_bile_salt3.46011873
7MP0006082_CNS_inflammation3.45218188
8MP0009840_abnormal_foam_cell3.33836811
9MP0001835_abnormal_antigen_presentation2.87555494
10MP0003172_abnormal_lysosome_physiology2.75328588
11MP0009278_abnormal_bone_marrow2.54140683
12MP0003252_abnormal_bile_duct2.42585173
13MP0003300_gastrointestinal_ulcer2.35652780
14MP0003436_decreased_susceptibility_to2.26257599
15MP0005464_abnormal_platelet_physiology2.16587477
16MP0002419_abnormal_innate_immunity2.09315330
17MP0002148_abnormal_hypersensitivity_rea2.02940193
18MP0003724_increased_susceptibility_to2.02394975
19MP0000685_abnormal_immune_system1.93448744
20MP0008875_abnormal_xenobiotic_pharmacok1.92872386
21MP0003075_altered_response_to1.83070852
22MP0010329_abnormal_lipoprotein_level1.79714118
23MP0003690_abnormal_glial_cell1.74861321
24MP0005025_abnormal_response_to1.71822958
25MP0004019_abnormal_vitamin_homeostasis1.69192299
26MP0005310_abnormal_salivary_gland1.67814656
27MP0005671_abnormal_response_to1.67043854
28MP0000609_abnormal_liver_physiology1.64635117
29MP0003303_peritoneal_inflammation1.62339173
30MP0009785_altered_susceptibility_to1.61318446
31MP0005670_abnormal_white_adipose1.56263673
32MP0005000_abnormal_immune_tolerance1.56049751
33MP0005171_absent_coat_pigmentation1.51573422
34MP0008469_abnormal_protein_level1.51555116
35MP0001800_abnormal_humoral_immune1.50071041
36MP0005387_immune_system_phenotype1.49184694
37MP0001790_abnormal_immune_system1.49184694
38MP0002452_abnormal_antigen_presenting1.48355984
39MP0005397_hematopoietic_system_phenotyp1.45026928
40MP0001545_abnormal_hematopoietic_system1.45026928
41MP0002723_abnormal_immune_serum1.41131504
42MP0002405_respiratory_system_inflammati1.40905184
43MP0008004_abnormal_stomach_pH1.40622985
44MP0002138_abnormal_hepatobiliary_system1.36693059
45MP0009764_decreased_sensitivity_to1.36227591
46MP0003045_fibrosis1.35813401
47MP0005332_abnormal_amino_acid1.35320453
48MP0003828_pulmonary_edema1.32322215
49MP0000371_diluted_coat_color1.32278317
50MP0001853_heart_inflammation1.32022201
51MP0002837_dystrophic_cardiac_calcinosis1.30451890
52MP0002118_abnormal_lipid_homeostasis1.29560784
53MP0001845_abnormal_inflammatory_respons1.29316937
54MP0001533_abnormal_skeleton_physiology1.28228073
55MP0001666_abnormal_nutrient_absorption1.25920898
56MP0005319_abnormal_enzyme/_coenzyme1.25702354
57MP0005083_abnormal_biliary_tract1.23605280
58MP0005451_abnormal_body_composition1.22472959
59MP0000343_altered_response_to1.22425978
60MP0002166_altered_tumor_susceptibility1.21915074
61MP0003453_abnormal_keratinocyte_physiol1.20622395
62MP0008260_abnormal_autophagy1.20420915
63MP0000858_altered_metastatic_potential1.16703800
64MP0002009_preneoplasia1.16279722
65MP0004510_myositis1.15297891
66MP0009115_abnormal_fat_cell1.14973406
67MP0000920_abnormal_myelination1.14923912
68MP0005174_abnormal_tail_pigmentation1.14638706
69MP0008057_abnormal_DNA_replication1.13937184
70MP0002254_reproductive_system_inflammat1.13007062
71MP0004130_abnormal_muscle_cell1.11497921
72MP0001819_abnormal_immune_cell1.08017271
73MP0003329_amyloid_beta_deposits1.06329911
74MP0003806_abnormal_nucleotide_metabolis1.05149801
75MP0000604_amyloidosis1.04609831
76MP0002420_abnormal_adaptive_immunity1.04167212
77MP0010155_abnormal_intestine_physiology1.03428157
78MP0009763_increased_sensitivity_to1.02443633
79MP0002277_abnormal_respiratory_mucosa1.02144713
80MP0003656_abnormal_erythrocyte_physiolo1.00714072
81MP0001764_abnormal_homeostasis0.99340420
82MP0002006_tumorigenesis0.97736244
83MP0005076_abnormal_cell_differentiation0.97253618
84MP0000465_gastrointestinal_hemorrhage0.96807446
85MP0005167_abnormal_blood-brain_barrier0.96430536
86MP0002998_abnormal_bone_remodeling0.96416330
87MP0000015_abnormal_ear_pigmentation0.96245811
88MP0005166_decreased_susceptibility_to0.95664411
89MP0006054_spinal_hemorrhage0.93687395
90MP0003183_abnormal_peptide_metabolism0.93388219
91MP0000598_abnormal_liver_morphology0.93325641
92MP0000689_abnormal_spleen_morphology0.91190330
93MP0002398_abnormal_bone_marrow0.91035810
94MP0002429_abnormal_blood_cell0.90057675
95MP0003705_abnormal_hypodermis_morpholog0.88685397
96MP0005584_abnormal_enzyme/coenzyme_acti0.88364546
97MP0002928_abnormal_bile_duct0.86925895
98MP0002971_abnormal_brown_adipose0.86913339
99MP0005164_abnormal_response_to0.85464877
100MP0004883_abnormal_blood_vessel0.85204407
101MP0003186_abnormal_redox_activity0.84879110
102MP0002332_abnormal_exercise_endurance0.84185739
103MP0003448_altered_tumor_morphology0.83920912
104MP0000249_abnormal_blood_vessel0.82873272
105MP0005334_abnormal_fat_pad0.82198789
106MP0004947_skin_inflammation0.82185594
107MP0003195_calcinosis0.81638654
108MP0000716_abnormal_immune_system0.81302753
109MP0009333_abnormal_splenocyte_physiolog0.80159594
110MP0000569_abnormal_digit_pigmentation0.79929097
111MP0003795_abnormal_bone_structure0.79911921
112MP0005390_skeleton_phenotype0.79605369
113MP0010307_abnormal_tumor_latency0.78824710
114MP0003879_abnormal_hair_cell0.77816022
115MP0005023_abnormal_wound_healing0.77748711
116MP0002722_abnormal_immune_system0.75429974
117MP0002090_abnormal_vision0.75036358
118MP0005165_increased_susceptibility_to0.74674080
119MP0009643_abnormal_urine_homeostasis0.74505848
120MP0001851_eye_inflammation0.73968198
121MP0005647_abnormal_sex_gland0.72410625
122MP0005075_abnormal_melanosome_morpholog0.71934716
123MP0002933_joint_inflammation0.70397966
124MP0005666_abnormal_adipose_tissue0.69866647
125MP0001663_abnormal_digestive_system0.68204739
126MP0003634_abnormal_glial_cell0.64864937
127MP0003633_abnormal_nervous_system0.62964087
128MP0003279_aneurysm0.61894946
129MP0002877_abnormal_melanocyte_morpholog0.58939401
130MP0005595_abnormal_vascular_smooth0.57069022
131MP0008874_decreased_physiological_sensi0.55797306
132MP0003091_abnormal_cell_migration0.51577637

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)7.42509655
2Complement deficiency (HP:0004431)6.29956690
3Glomerulonephritis (HP:0000099)5.84718322
4Abnormality of complement system (HP:0005339)5.17376167
5Disinhibition (HP:0000734)4.60605512
6Pustule (HP:0200039)4.32554771
7Loss of speech (HP:0002371)4.24351598
8Mutism (HP:0002300)4.18047123
9Myocardial infarction (HP:0001658)4.17933941
10Dysostosis multiplex (HP:0000943)4.17843805
11Recurrent gram-negative bacterial infections (HP:0005420)4.16155545
12Recurrent bacterial skin infections (HP:0005406)4.09918307
13Recurrent abscess formation (HP:0002722)4.00514737
14Nephritis (HP:0000123)3.96000987
15Mucopolysacchariduria (HP:0008155)3.80550731
16Urinary glycosaminoglycan excretion (HP:0003541)3.80550731
17Eczematoid dermatitis (HP:0000976)3.70212187
18Abnormality of mucopolysaccharide metabolism (HP:0011020)3.61493478
19Abnormality of polysaccharide metabolism (HP:0011012)3.61493478
20Abnormality of glycosaminoglycan metabolism (HP:0004371)3.61493478
21Increased IgM level (HP:0003496)3.55647419
22Axonal loss (HP:0003447)3.47429863
23Xanthomatosis (HP:0000991)3.38453759
24Joint hemorrhage (HP:0005261)3.34595811
25Abnormality of the vasculature of the conjunctiva (HP:0008054)3.24251584
26Vacuolated lymphocytes (HP:0001922)3.23196731
27Neurofibrillary tangles (HP:0002185)3.14987695
28Rectovaginal fistula (HP:0000143)3.14746028
29Rectal fistula (HP:0100590)3.14746028
30Intestinal fistula (HP:0100819)3.12391719
31Intrahepatic cholestasis (HP:0001406)3.11139968
32Abnormality of monocarboxylic acid metabolism (HP:0010996)3.10363168
33Vaginal fistula (HP:0004320)3.07432500
34Alopecia of scalp (HP:0002293)3.06177303
35Hypochromic microcytic anemia (HP:0004840)3.02406573
36Abnormality of aromatic amino acid family metabolism (HP:0004338)3.00080088
37Stomatitis (HP:0010280)2.99024815
38Purpura (HP:0000979)2.98946340
39Deep venous thrombosis (HP:0002625)2.98392137
40Myositis (HP:0100614)2.96172177
41Nuclear cataract (HP:0100018)2.95352059
42Orchitis (HP:0100796)2.94141620
43Prolonged partial thromboplastin time (HP:0003645)2.92735510
44Agnosia (HP:0010524)2.90876570
45Obstructive lung disease (HP:0006536)2.88966350
46Chronic obstructive pulmonary disease (HP:0006510)2.88966350
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.85941504
48Colitis (HP:0002583)2.82955782
49Abnormality of liposaccharide metabolism (HP:0010968)2.77866489
50Abnormality of glycosphingolipid metabolism (HP:0004343)2.77866489
51Abnormality of glycolipid metabolism (HP:0010969)2.77866489
52Increased cerebral lipofuscin (HP:0011813)2.74349166
53Autoimmune thrombocytopenia (HP:0001973)2.73570161
54Optic neuritis (HP:0100653)2.73405983
55Retrobulbar optic neuritis (HP:0100654)2.73405983
56Inappropriate behavior (HP:0000719)2.66653388
57Cerebral aneurysm (HP:0004944)2.65827359
58Hypobetalipoproteinemia (HP:0003563)2.64664862
59Increased neuronal autofluorescent lipopigment (HP:0002074)2.64162578
60Urethral obstruction (HP:0000796)2.61974062
61Abnormality of glutamine family amino acid metabolism (HP:0010902)2.59304275
62Neuronal loss in central nervous system (HP:0002529)2.54377330
63Polycythemia (HP:0001901)2.51250393
64Increased serum ferritin (HP:0003281)2.49980407
65Turricephaly (HP:0000262)2.49173683
66Hypercholesterolemia (HP:0003124)2.48606600
67Apathy (HP:0000741)2.43383975
68Upper motor neuron abnormality (HP:0002127)2.42904435
69Diminished motivation (HP:0000745)2.40972952
70Recurrent skin infections (HP:0001581)2.40859781
71Abnormality of macrophages (HP:0004311)2.38242814
72Thick nail (HP:0001805)2.37485460
73Albinism (HP:0001022)2.36444105
74Progressive neurologic deterioration (HP:0002344)2.33259169
75Hemoptysis (HP:0002105)2.33017666
76Petechiae (HP:0000967)2.32494645
77Epidermoid cyst (HP:0200040)2.31681716
78Peripheral demyelination (HP:0011096)2.29948173
79Pathologic fracture (HP:0002756)2.29549225
80Pulmonary infiltrates (HP:0002113)2.28635270
81Abnormality of pyrimidine metabolism (HP:0004353)2.27942433
82Recurrent fungal infections (HP:0002841)2.25971086
83Hyperlipoproteinemia (HP:0010980)2.25960259
84Hypolipoproteinemia (HP:0010981)2.25660734
85Retinal atrophy (HP:0001105)2.25340124
86Chronic mucocutaneous candidiasis (HP:0002728)2.23041600
87Recurrent cutaneous fungal infections (HP:0011370)2.23041600
88Asymmetric septal hypertrophy (HP:0001670)2.20381238
89Hypoalphalipoproteinemia (HP:0003233)2.20246407
90Urticaria (HP:0001025)2.20045023
91Global brain atrophy (HP:0002283)2.19703799
92Dementia (HP:0000726)2.18288771
93Intestinal atresia (HP:0011100)2.18265040
94Orthostatic hypotension (HP:0001278)2.17744619
95Meningitis (HP:0001287)2.17022976
96Abnormality of the common coagulation pathway (HP:0010990)2.16571918
97Abnormality of sulfur amino acid metabolism (HP:0004339)2.15727807
98Hyperammonemia (HP:0001987)2.15258661
99Cerebral inclusion bodies (HP:0100314)2.15114187
100Cardiomegaly (HP:0001640)2.14187079
101Lower limb hyperreflexia (HP:0002395)2.14040905
102Personality changes (HP:0000751)2.13545846
103Abnormality of iron homeostasis (HP:0011031)2.13330524
104Amyloidosis (HP:0011034)2.12748232
105Fat malabsorption (HP:0002630)2.11921407
106Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.09888474
107Hypokinesia (HP:0002375)2.09082648
108Spontaneous hematomas (HP:0007420)2.08292314
109Hemorrhage of the eye (HP:0011885)2.06807380
110Esophageal varix (HP:0002040)2.05828998
111Conjunctival telangiectasia (HP:0000524)2.05659173
112Malnutrition (HP:0004395)2.02993111
113Polyneuropathy (HP:0001271)2.02870030
114Gingival bleeding (HP:0000225)2.02762935
115Increased IgE level (HP:0003212)2.00855442
116Gingivitis (HP:0000230)2.00421210
117Elevated erythrocyte sedimentation rate (HP:0003565)2.00233544
118Metaphyseal irregularity (HP:0003025)1.99559860
119Progressive visual loss (HP:0000529)1.98912783
120Mediastinal lymphadenopathy (HP:0100721)1.98083524
121Vasculitis (HP:0002633)1.96989669
122Prolonged neonatal jaundice (HP:0006579)1.95981135
123Abnormality of male internal genitalia (HP:0000022)1.94222460
124Ketosis (HP:0001946)1.92950044
125Prostate neoplasm (HP:0100787)1.92136489
126Abnormal enzyme/coenzyme activity (HP:0012379)1.91763108
127Bone cyst (HP:0012062)1.91339941
128Inflammation of the large intestine (HP:0002037)1.91019101
129Anorexia (HP:0002039)1.90757850
130Coarse hair (HP:0002208)1.89994516
131Abnormality of the periventricular white matter (HP:0002518)1.89820516
132Hydroxyprolinuria (HP:0003080)1.89457078
133Abnormality of proline metabolism (HP:0010907)1.89457078
134Periodontitis (HP:0000704)1.89363460
135Keratoconjunctivitis sicca (HP:0001097)1.89346771
136Thoracic kyphosis (HP:0002942)1.88767933
137Hematochezia (HP:0002573)1.88732286
138Recurrent viral infections (HP:0004429)1.87810617
139Hepatosplenomegaly (HP:0001433)1.87462331
140Hyperglycinuria (HP:0003108)1.86971810
141Memory impairment (HP:0002354)1.85424182
142Increased CSF protein (HP:0002922)1.83960380
143Hypochromic anemia (HP:0001931)1.83704706
144Joint stiffness (HP:0001387)1.83207004
145IgA deficiency (HP:0002720)1.83176320
146Rib fusion (HP:0000902)1.81861447
147Abnormality of alkaline phosphatase activity (HP:0004379)1.81187303
148Basal ganglia calcification (HP:0002135)1.80051331
149Abnormality of methionine metabolism (HP:0010901)1.79392598
150Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.78935597
151Supranuclear gaze palsy (HP:0000605)1.78599899
152Epistaxis (HP:0000421)1.76497453
153Restrictive lung disease (HP:0002091)1.76137888
154T lymphocytopenia (HP:0005403)1.74908195
155Pulmonary embolism (HP:0002204)1.74700623
156Abnormality of transition element cation homeostasis (HP:0011030)1.72581718
157Keratoconjunctivitis (HP:0001096)1.71591426
158Bone pain (HP:0002653)1.70676310

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.80707950
2ICK4.11268702
3TGFBR23.83719678
4MAP3K62.98528906
5TYK22.74585867
6CSK2.54779058
7DDR22.53980307
8MATK2.46404560
9FGR2.26575384
10MAP3K112.22791717
11MAP3K142.14737171
12BLK2.13741463
13PIM22.06983382
14PINK12.06140334
15NME22.06134420
16GRK72.04926095
17ACVR1B2.03124030
18CAMKK21.98578378
19MAP3K31.97769128
20TBK11.96929893
21RIPK41.91662962
22IRAK31.83150242
23YES11.75705050
24BMX1.69414861
25ERN11.68798373
26FES1.63194537
27CAMK1D1.61900278
28IRAK41.56843007
29IKBKB1.55634194
30TAOK11.47568101
31JAK11.42884624
32CDK61.42058806
33CSF1R1.40452165
34TRPM71.35384140
35PRPF4B1.33733050
36PDGFRA1.30313803
37DYRK1B1.24685320
38MAP4K11.24036840
39TAOK21.23396541
40KIT1.23339543
41TNK21.22393974
42MAPK111.22298976
43PIM11.18896455
44FGFR41.17414936
45MARK31.16941140
46ZAP701.16459675
47MAP3K11.16320536
48IKBKE1.12471535
49ABL21.12345782
50LYN1.10524470
51JAK21.07871909
52TGFBR11.04279766
53GSK3A1.02273803
54TYRO30.99042346
55PRKD20.97370940
56CAMK1G0.97194101
57NEK90.94497444
58EPHB10.94203440
59CHUK0.94063049
60PDK20.94009637
61TAOK30.93458130
62DAPK10.93354852
63RPS6KC10.92239587
64RPS6KL10.92239587
65HCK0.88188484
66EGFR0.87795742
67IRAK20.86712030
68IRAK10.86336979
69RPS6KA60.85578016
70TXK0.84916189
71PDPK10.83145213
72JAK30.81816069
73LCK0.79626508
74FRK0.76568879
75INSRR0.76097068
76PRKAA20.75592455
77BCKDK0.73214219
78SIK20.70492527
79SIK10.68999780
80MAP2K60.67980591
81ITK0.67247717
82PDK10.66262637
83STK100.65617178
84STK30.60825057
85MAP3K20.57732846
86PDGFRB0.55391782
87MAP2K30.54901002
88MARK20.53041560
89PRKAA10.52723013
90DAPK20.52444894
91PBK0.52314359
92CAMKK10.51312422
93ABL10.50973463
94MAP3K130.50654533
95MOS0.50024863
96MAPK120.49883367
97AKT30.48915028
98MAPK70.48481208
99SYK0.47844848
100MAPK40.47197755
101TEC0.47060650
102LATS10.46526411
103MAP3K100.46290318
104EIF2AK20.46044850
105PTK60.45026065
106PRKCD0.44554124
107TESK20.43861712
108CDC42BPA0.43707843
109INSR0.42251562
110KSR20.42212903
111RPS6KA20.41342683
112BTK0.41163984
113RPS6KA10.41078353
114PRKG20.40016495
115MTOR0.39890461
116PIK3CG0.39325860
117ADRBK20.38624976
118GRK60.37925495
119MAPKAPK20.37078283
120CAMK40.35482201
121MAP3K50.33593129
122FYN0.32502847
123FGFR30.32365444
124EPHB20.32027989
125SIK30.31938187
126PRKCZ0.31880124
127MAPK30.30814340
128RIPK10.30794000
129PAK20.30165117
130CDK70.29791991
131BMPR20.29532217
132KSR10.29436890
133ARAF0.29436657
134CLK10.29134427
135STK40.29019102
136SGK30.28824358
137EPHA30.28172657
138CDK120.27959502
139PRKCQ0.27783579
140IGF1R0.27059085

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.95269096
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.05041134
3Complement and coagulation cascades_Homo sapiens_hsa046103.04694703
4Asthma_Homo sapiens_hsa053102.53960343
5Arginine biosynthesis_Homo sapiens_hsa002202.49880961
6Fatty acid biosynthesis_Homo sapiens_hsa000612.42934314
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.42457154
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.40311230
9Nitrogen metabolism_Homo sapiens_hsa009102.30934199
10Autoimmune thyroid disease_Homo sapiens_hsa053202.24784305
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.21407725
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.14410373
13Type I diabetes mellitus_Homo sapiens_hsa049401.96841762
14Antigen processing and presentation_Homo sapiens_hsa046121.93185654
15Lysosome_Homo sapiens_hsa041421.82016336
16Tryptophan metabolism_Homo sapiens_hsa003801.71639255
17Fatty acid metabolism_Homo sapiens_hsa012121.64982721
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.63456589
19Other glycan degradation_Homo sapiens_hsa005111.56462518
20PPAR signaling pathway_Homo sapiens_hsa033201.55894417
21Caffeine metabolism_Homo sapiens_hsa002321.54191977
22Collecting duct acid secretion_Homo sapiens_hsa049661.52265456
23Leishmaniasis_Homo sapiens_hsa051401.46898137
24ABC transporters_Homo sapiens_hsa020101.42311583
25Pertussis_Homo sapiens_hsa051331.41688719
26Fatty acid degradation_Homo sapiens_hsa000711.41558642
27Hematopoietic cell lineage_Homo sapiens_hsa046401.40604577
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.40279146
29Legionellosis_Homo sapiens_hsa051341.39250152
30Prion diseases_Homo sapiens_hsa050201.38327648
31Osteoclast differentiation_Homo sapiens_hsa043801.38167970
32Peroxisome_Homo sapiens_hsa041461.26743812
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22458103
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18475313
35Arginine and proline metabolism_Homo sapiens_hsa003301.17890752
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17055254
37Lysine degradation_Homo sapiens_hsa003101.16924887
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16853949
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.16609355
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.14281716
41Starch and sucrose metabolism_Homo sapiens_hsa005001.08082140
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06708663
43Chemical carcinogenesis_Homo sapiens_hsa052041.05919943
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.05333334
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02353082
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01552074
47Fat digestion and absorption_Homo sapiens_hsa049751.00838527
48Tuberculosis_Homo sapiens_hsa051520.99948417
49Folate biosynthesis_Homo sapiens_hsa007900.99453337
50Sphingolipid metabolism_Homo sapiens_hsa006000.98081632
51beta-Alanine metabolism_Homo sapiens_hsa004100.97556859
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96330135
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.95176691
54Histidine metabolism_Homo sapiens_hsa003400.94612694
55Measles_Homo sapiens_hsa051620.93292177
56B cell receptor signaling pathway_Homo sapiens_hsa046620.92345761
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92017529
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91784490
59Graft-versus-host disease_Homo sapiens_hsa053320.91510317
60Notch signaling pathway_Homo sapiens_hsa043300.91239877
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88837742
62Retinol metabolism_Homo sapiens_hsa008300.87611144
63Malaria_Homo sapiens_hsa051440.86934542
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.81390631
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.81187121
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.80884609
67Influenza A_Homo sapiens_hsa051640.77294168
68African trypanosomiasis_Homo sapiens_hsa051430.76344022
69Allograft rejection_Homo sapiens_hsa053300.76036658
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75030537
71Vitamin digestion and absorption_Homo sapiens_hsa049770.73542233
72Selenocompound metabolism_Homo sapiens_hsa004500.73505191
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70641984
74Steroid biosynthesis_Homo sapiens_hsa001000.70567813
75Bile secretion_Homo sapiens_hsa049760.70036585
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69053433
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.67484670
78Platelet activation_Homo sapiens_hsa046110.66777665
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66698692
80T cell receptor signaling pathway_Homo sapiens_hsa046600.65768231
81Propanoate metabolism_Homo sapiens_hsa006400.65581353
82Hepatitis C_Homo sapiens_hsa051600.65554305
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65523050
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65069178
85Acute myeloid leukemia_Homo sapiens_hsa052210.64505945
86Amoebiasis_Homo sapiens_hsa051460.63149077
87Phenylalanine metabolism_Homo sapiens_hsa003600.61177538
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60649313
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60420388
90Vibrio cholerae infection_Homo sapiens_hsa051100.59191555
91Biosynthesis of amino acids_Homo sapiens_hsa012300.59081336
92Butanoate metabolism_Homo sapiens_hsa006500.58343425
93Phagosome_Homo sapiens_hsa041450.57482332
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56895028
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56878268
96Salmonella infection_Homo sapiens_hsa051320.56359501
97Toxoplasmosis_Homo sapiens_hsa051450.56151867
98Herpes simplex infection_Homo sapiens_hsa051680.55714408
99Hepatitis B_Homo sapiens_hsa051610.55686369
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55295983
101Chemokine signaling pathway_Homo sapiens_hsa040620.54784639
102Glycerolipid metabolism_Homo sapiens_hsa005610.54111804
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53980274
104Galactose metabolism_Homo sapiens_hsa000520.53372465
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.52350143
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.50511103
107Rheumatoid arthritis_Homo sapiens_hsa053230.50221657
108Shigellosis_Homo sapiens_hsa051310.49204183
109Mineral absorption_Homo sapiens_hsa049780.48931106
110Viral myocarditis_Homo sapiens_hsa054160.48383374
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48320650
112Adherens junction_Homo sapiens_hsa045200.48258445
113Apoptosis_Homo sapiens_hsa042100.48142405
114TNF signaling pathway_Homo sapiens_hsa046680.45272143
115Fructose and mannose metabolism_Homo sapiens_hsa000510.44881051
116Primary immunodeficiency_Homo sapiens_hsa053400.44268490
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43938165
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43784801
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43168150
120Ether lipid metabolism_Homo sapiens_hsa005650.42053179
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.41924318
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40349115
123mTOR signaling pathway_Homo sapiens_hsa041500.39391108
124Endocytosis_Homo sapiens_hsa041440.38977264
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.38910982
126GnRH signaling pathway_Homo sapiens_hsa049120.38829952
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38806509
128Bladder cancer_Homo sapiens_hsa052190.38449407
129Prolactin signaling pathway_Homo sapiens_hsa049170.36542017
130Dorso-ventral axis formation_Homo sapiens_hsa043200.35617740
131VEGF signaling pathway_Homo sapiens_hsa043700.35614192
132Systemic lupus erythematosus_Homo sapiens_hsa053220.34595778
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.34445251
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.33800105
135Arachidonic acid metabolism_Homo sapiens_hsa005900.32486786
136HIF-1 signaling pathway_Homo sapiens_hsa040660.32183687
137Epstein-Barr virus infection_Homo sapiens_hsa051690.29597771
138Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27857345
139Synaptic vesicle cycle_Homo sapiens_hsa047210.27713650
140Type II diabetes mellitus_Homo sapiens_hsa049300.26460432
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26080247
142Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25318996
143Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24715041
144Renal cell carcinoma_Homo sapiens_hsa052110.23192084
145Renin secretion_Homo sapiens_hsa049240.19819733
146HTLV-I infection_Homo sapiens_hsa051660.18948735
147Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18656300
148Pancreatic cancer_Homo sapiens_hsa052120.16405513
149Estrogen signaling pathway_Homo sapiens_hsa049150.16268429
150Sulfur metabolism_Homo sapiens_hsa009200.13929560

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