ADAR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.49359564
2locomotory exploration behavior (GO:0035641)5.16871468
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.81878525
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.57930035
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.57930035
6antigen processing and presentation of endogenous antigen (GO:0019883)4.31684095
7negative regulation of cell killing (GO:0031342)4.23766964
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.23766964
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.17054273
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.16221987
11positive regulation of gamma-delta T cell activation (GO:0046645)4.05157048
12sodium ion export (GO:0071436)3.95606558
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.95433065
14regulation of synaptic vesicle exocytosis (GO:2000300)3.88560821
15regulation of ARF protein signal transduction (GO:0032012)3.85161680
16detection of other organism (GO:0098543)3.84336900
17synaptic vesicle exocytosis (GO:0016079)3.79059797
18detection of bacterium (GO:0016045)3.70043929
19regulation of interferon-beta biosynthetic process (GO:0045357)3.65598479
20glutamate secretion (GO:0014047)3.63453589
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.59219459
22regulation of glutamate receptor signaling pathway (GO:1900449)3.59191704
23negative thymic T cell selection (GO:0045060)3.51097866
24response to peptidoglycan (GO:0032494)3.48725847
25regulation of synaptic vesicle transport (GO:1902803)3.46053940
26neurotransmitter secretion (GO:0007269)3.46030423
27response to host immune response (GO:0052572)3.44272896
28response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.44272896
29regulation of synapse structural plasticity (GO:0051823)3.44164246
30positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.42948694
31vocalization behavior (GO:0071625)3.42495241
32exploration behavior (GO:0035640)3.41580764
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.38819897
34layer formation in cerebral cortex (GO:0021819)3.38471850
35response to host (GO:0075136)3.37360403
36response to host defenses (GO:0052200)3.37360403
37response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.37360403
38leukocyte aggregation (GO:0070486)3.36583994
39negative regulation of erythrocyte differentiation (GO:0045647)3.36544728
40negative T cell selection (GO:0043383)3.36507797
41detection of external biotic stimulus (GO:0098581)3.34221463
42cellular response to interleukin-15 (GO:0071350)3.33890472
43positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.33066696
44negative regulation of interleukin-12 production (GO:0032695)3.32550768
45detection of molecule of bacterial origin (GO:0032490)3.32285135
46negative regulation of lymphocyte mediated immunity (GO:0002707)3.28113568
47G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.27266539
48proline transport (GO:0015824)3.27237310
49histone H3-K36 demethylation (GO:0070544)3.25302282
50cellular potassium ion homeostasis (GO:0030007)3.25102595
51activation of protein kinase A activity (GO:0034199)3.20498929
52regulation of neuronal synaptic plasticity (GO:0048168)3.18732353
53regulation of long-term neuronal synaptic plasticity (GO:0048169)3.18518741
54positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.18164316
55negative regulation of T cell mediated immunity (GO:0002710)3.15985023
56antigen processing and presentation via MHC class Ib (GO:0002475)3.15435772
57response to muramyl dipeptide (GO:0032495)3.08785756
58nuclear pore complex assembly (GO:0051292)3.08218374
59ionotropic glutamate receptor signaling pathway (GO:0035235)3.06270569
60gamma-aminobutyric acid transport (GO:0015812)3.04914136
61regulation of gamma-delta T cell differentiation (GO:0045586)3.04192184
62* response to interferon-alpha (GO:0035455)3.03311936
63negative regulation of leukocyte mediated immunity (GO:0002704)3.00776805
64detection of biotic stimulus (GO:0009595)3.00292856
65germinal center formation (GO:0002467)2.98651978
66regulation of ARF GTPase activity (GO:0032312)2.97280262
67immunoglobulin mediated immune response (GO:0016064)2.96374990
68clathrin coat assembly (GO:0048268)2.95734208
69regulation of B cell receptor signaling pathway (GO:0050855)2.94862587
70positive regulation of Rap GTPase activity (GO:0032854)2.94856444
71interferon-gamma-mediated signaling pathway (GO:0060333)2.94701701
72cellular extravasation (GO:0045123)2.94338239
73signal complex assembly (GO:0007172)2.93944033
74positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.91896905
75cellular response to interferon-alpha (GO:0035457)2.91681490
76regulation of gamma-delta T cell activation (GO:0046643)2.90780906
77* response to type I interferon (GO:0034340)2.89372096
78neuromuscular process controlling balance (GO:0050885)2.89004484
79thymic T cell selection (GO:0045061)2.87157177
80* type I interferon signaling pathway (GO:0060337)2.86832359
81* cellular response to type I interferon (GO:0071357)2.86832359
82negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.86195431
83long-term memory (GO:0007616)2.85236615
84prepulse inhibition (GO:0060134)2.84306718
85regulation of interleukin-12 biosynthetic process (GO:0045075)2.84180553
86neutrophil activation involved in immune response (GO:0002283)2.83638976
87positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.83545324
88T cell selection (GO:0045058)2.78685966
89regulation of necroptotic process (GO:0060544)2.78377059
90cellular response to virus (GO:0098586)2.77929482
91cerebellar Purkinje cell differentiation (GO:0021702)2.77347137
92positive regulation of Cdc42 GTPase activity (GO:0043089)2.77274959
93regulation of Rap GTPase activity (GO:0032317)2.74800195
94synaptic vesicle endocytosis (GO:0048488)2.71715250
95positive thymic T cell selection (GO:0045059)2.70880057
96positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.70046235
97lipopolysaccharide-mediated signaling pathway (GO:0031663)2.69676735
98regulation of T cell tolerance induction (GO:0002664)2.68744222
99regulation of histone H3-K27 methylation (GO:0061085)2.67816314
100regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.66752144
101* negative regulation of viral genome replication (GO:0045071)2.66420220
102positive regulation of interferon-beta production (GO:0032728)2.66128342
103B cell receptor signaling pathway (GO:0050853)2.64540622
104B cell mediated immunity (GO:0019724)2.62446795
105glycine transport (GO:0015816)2.62343387
106vesicle transport along microtubule (GO:0047496)2.62199841
107neurotransmitter-gated ion channel clustering (GO:0072578)2.61731749
108production of molecular mediator involved in inflammatory response (GO:0002532)2.60129852
109protein localization to synapse (GO:0035418)2.59974706
110regulation of clathrin-mediated endocytosis (GO:2000369)2.59714023
111regulation of dendritic cell antigen processing and presentation (GO:0002604)2.59694242
112regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.59179966
113protein localization to endosome (GO:0036010)2.58467795
114cytoskeletal anchoring at plasma membrane (GO:0007016)2.58132719
115defense response to protozoan (GO:0042832)2.57668438
116positive regulation of membrane potential (GO:0045838)2.57549758
117regulation of defense response to virus by virus (GO:0050690)2.54747371
118myeloid dendritic cell differentiation (GO:0043011)2.54518268
119regulation of RNA export from nucleus (GO:0046831)2.53923353
120regulation of nucleobase-containing compound transport (GO:0032239)2.52815372
121nerve growth factor signaling pathway (GO:0038180)2.51943126
122response to interleukin-15 (GO:0070672)2.51379072
123regulation of tolerance induction (GO:0002643)2.50979091
124regulation of B cell differentiation (GO:0045577)2.50289066
125negative regulation of toll-like receptor signaling pathway (GO:0034122)2.50227773
126regulation of synaptic plasticity (GO:0048167)2.48162082
127myeloid cell activation involved in immune response (GO:0002275)2.48105013
128positive regulation of interferon-alpha production (GO:0032727)2.48028854
129negative regulation of type 2 immune response (GO:0002829)2.47819684
130tolerance induction (GO:0002507)2.46516221
131respiratory burst (GO:0045730)2.46235091
132regulation of excitatory postsynaptic membrane potential (GO:0060079)2.45952953
133synaptic transmission, glutamatergic (GO:0035249)2.45618241
1343-UTR-mediated mRNA stabilization (GO:0070935)2.45411571
135regulation of NFAT protein import into nucleus (GO:0051532)2.45257021
136potassium ion import (GO:0010107)2.44831064
137microglial cell activation (GO:0001774)2.43889984
138response to auditory stimulus (GO:0010996)2.43761311
139regulation of type I interferon-mediated signaling pathway (GO:0060338)2.43680383
140regulation of natural killer cell mediated immunity (GO:0002715)2.43644116
141regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.43644116
142macrophage activation (GO:0042116)2.43612599
143positive regulation by symbiont of host defense response (GO:0052509)2.43597626
144modulation by symbiont of host defense response (GO:0052031)2.43597626
145modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.43597626
146modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.43597626
147positive regulation by organism of defense response of other organism involved in symbiotic interact2.43597626
148modulation by symbiont of host immune response (GO:0052553)2.43597626
149neurotransmitter transport (GO:0006836)2.42960579
150positive regulation of synapse maturation (GO:0090129)2.42917761
151positive regulation of cellular amide metabolic process (GO:0034250)2.42599732
152NIK/NF-kappaB signaling (GO:0038061)2.42293472
153positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.41821440
154positive T cell selection (GO:0043368)2.41298910
155positive regulation of synaptic transmission, GABAergic (GO:0032230)2.38976185
156JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.38607830
157T cell migration (GO:0072678)2.38151018
158macrophage activation involved in immune response (GO:0002281)2.37904020
159regulation of interferon-alpha production (GO:0032647)2.36988718
160alanine transport (GO:0032328)2.36621529
161membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.36372395
162dendritic spine morphogenesis (GO:0060997)2.34520080

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.72261399
2* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.65469797
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.96691379
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.93722549
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.84314259
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.77958656
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.71345623
8* MYC_22102868_ChIP-Seq_BL_Human2.68752368
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.68513901
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.62207078
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.57152234
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.50736307
13EZH2_22144423_ChIP-Seq_EOC_Human2.49618068
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.46849959
15E2F7_22180533_ChIP-Seq_HELA_Human2.42579880
16DROSHA_22980978_ChIP-Seq_HELA_Human2.41643823
17* KDM2B_26808549_Chip-Seq_DND41_Human2.36961403
18* TCF7_22412390_ChIP-Seq_EML_Mouse2.17264058
19* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.15844346
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.14226019
21* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.11263168
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.10248448
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.99604661
24IRF8_27001747_Chip-Seq_BMDM_Mouse1.95534474
25RUNX_20019798_ChIP-Seq_JUKART_Human1.95294742
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.93786664
27SPI1_23127762_ChIP-Seq_K562_Human1.92825471
28* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.92582306
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.89715214
30VDR_21846776_ChIP-Seq_THP-1_Human1.88123498
31SPI1_23547873_ChIP-Seq_NB4_Human1.87087712
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.86955866
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.83388069
34* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.83045714
35* MAF_26560356_Chip-Seq_TH1_Human1.81853728
36KDM2B_26808549_Chip-Seq_K562_Human1.80601860
37SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79867891
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.76645252
39KDM2B_26808549_Chip-Seq_JURKAT_Human1.76428061
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.73028840
41LXR_22292898_ChIP-Seq_THP-1_Human1.70195248
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69341258
43REST_21632747_ChIP-Seq_MESCs_Mouse1.69203129
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.68375143
45* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.66862256
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.66479396
47* UTX_26944678_Chip-Seq_JUKART_Human1.57089079
48ZFP281_27345836_Chip-Seq_ESCs_Mouse1.56077825
49REST_18959480_ChIP-ChIP_MESCs_Mouse1.52649937
50SCL_19346495_ChIP-Seq_HPC-7_Human1.50409839
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49564675
52MYB_26560356_Chip-Seq_TH2_Human1.49167151
53STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48840126
54SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.46461795
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.44151164
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42738111
57* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.42169909
58VDR_24763502_ChIP-Seq_THP-1_Human1.41321994
59* RACK7_27058665_Chip-Seq_MCF-7_Human1.40187451
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.39705587
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.38752989
62DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.36765116
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.36419629
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.30284852
65PU_27001747_Chip-Seq_BMDM_Mouse1.29466483
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28818531
67SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.28122604
68CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27813509
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26467186
70* MYB_26560356_Chip-Seq_TH1_Human1.25476094
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25467773
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21554612
73RUNX1_22412390_ChIP-Seq_EML_Mouse1.21391028
74GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21136886
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20177677
76MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20023956
77NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.19156687
78* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19069563
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16443755
80GATA1_19941826_ChIP-Seq_K562_Human1.16007380
81SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.15643827
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14247398
83GATA3_27048872_Chip-Seq_THYMUS_Human1.13897889
84BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12331200
85STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09464633
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09351764
87* NCOR1_26117541_ChIP-Seq_K562_Human1.09239917
88SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.08784659
89* MAF_26560356_Chip-Seq_TH2_Human1.08224443
90TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08220096
91* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07910647
92CLOCK_20551151_ChIP-Seq_293T_Human1.07311077
93TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.06915004
94* SMC4_20622854_ChIP-Seq_HELA_Human1.06143574
95MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06061216
96GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05042364
97FOXM1_23109430_ChIP-Seq_U2OS_Human1.04048332
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03695353
99VDR_24787735_ChIP-Seq_THP-1_Human1.03192564
100JARID2_20064375_ChIP-Seq_MESCs_Mouse1.03105329
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02737994
102SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01928426
103GATA1_22025678_ChIP-Seq_K562_Human1.01510707
104RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99588922
105EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99588922
106ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99514732
107CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99187447
108CIITA_25753668_ChIP-Seq_RAJI_Human0.98602122
109* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96003185
110ESR2_21235772_ChIP-Seq_MCF-7_Human0.95891751
111* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95758437
112STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95599999
113AR_21572438_ChIP-Seq_LNCaP_Human0.95275550
114PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95090130
115PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94763746
116CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94508648
117RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94078294
118* TFEB_21752829_ChIP-Seq_HELA_Human0.94042395
119P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94039213
120CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93158264
121NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93153507
122RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93101650
123RUNX1_27514584_Chip-Seq_MCF-7_Human0.92829371
124RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91508524
125* GATA2_21666600_ChIP-Seq_HMVEC_Human0.90635443
126ELF1_20517297_ChIP-Seq_JURKAT_Human0.90610224
127SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90148177
128RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89091408
129PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89065757
130ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88972830
131* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88608798
132RNF2_27304074_Chip-Seq_ESCs_Mouse0.88518410
133SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.87897098
134WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86196085
135P68_20966046_ChIP-Seq_HELA_Human0.86171457
136CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86085907
137NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.85959738
138RXR_22108803_ChIP-Seq_LS180_Human0.85364864

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.00222855
2MP0000569_abnormal_digit_pigmentation3.22615756
3MP0003635_abnormal_synaptic_transmissio3.06415055
4MP0003303_peritoneal_inflammation2.99372918
5MP0003724_increased_susceptibility_to2.86005423
6MP0001835_abnormal_antigen_presentation2.79765306
7MP0004510_myositis2.73929011
8MP0003172_abnormal_lysosome_physiology2.47346999
9MP0002822_catalepsy2.32434672
10MP0002063_abnormal_learning/memory/cond2.31137051
11MP0009745_abnormal_behavioral_response2.27521924
12MP0000685_abnormal_immune_system2.21499286
13MP0002064_seizures2.19888066
14MP0005451_abnormal_body_composition2.19291491
15MP0009046_muscle_twitch2.17964026
16MP0005671_abnormal_response_to2.13226898
17MP0003880_abnormal_central_pattern2.05315500
18MP0003300_gastrointestinal_ulcer2.02910173
19MP0008260_abnormal_autophagy2.01947596
20MP0005423_abnormal_somatic_nervous1.99422734
21MP0005387_immune_system_phenotype1.98656301
22MP0001790_abnormal_immune_system1.98656301
23MP0002909_abnormal_adrenal_gland1.97163598
24MP0004270_analgesia1.93475749
25MP0003705_abnormal_hypodermis_morpholog1.90309620
26MP0008569_lethality_at_weaning1.88365622
27MP0003191_abnormal_cellular_cholesterol1.88107644
28MP0001800_abnormal_humoral_immune1.87810790
29MP0003075_altered_response_to1.82198183
30MP0008057_abnormal_DNA_replication1.80786810
31MP0005000_abnormal_immune_tolerance1.77932680
32MP0004858_abnormal_nervous_system1.77899818
33MP0002009_preneoplasia1.77806739
34MP0001501_abnormal_sleep_pattern1.76883853
35MP0008961_abnormal_basal_metabolism1.72639370
36MP0009333_abnormal_splenocyte_physiolog1.71584448
37MP0001968_abnormal_touch/_nociception1.68028027
38MP0002452_abnormal_antigen_presenting1.64354369
39MP0003763_abnormal_thymus_physiology1.62516403
40MP0002877_abnormal_melanocyte_morpholog1.62281372
41MP0002572_abnormal_emotion/affect_behav1.62039793
42MP0009785_altered_susceptibility_to1.60977392
43MP0004811_abnormal_neuron_physiology1.60487208
44MP0001819_abnormal_immune_cell1.58957458
45MP0002420_abnormal_adaptive_immunity1.58063938
46* MP0002723_abnormal_immune_serum1.57124615
47MP0004381_abnormal_hair_follicle1.56486949
48MP0010234_abnormal_vibrissa_follicle1.56225108
49MP0003787_abnormal_imprinting1.56107254
50MP0003436_decreased_susceptibility_to1.55096310
51* MP0002398_abnormal_bone_marrow1.52896980
52MP0001533_abnormal_skeleton_physiology1.51771283
53MP0003329_amyloid_beta_deposits1.50690711
54MP0002166_altered_tumor_susceptibility1.50665108
55MP0005025_abnormal_response_to1.49478316
56MP0000858_altered_metastatic_potential1.48953084
57MP0000604_amyloidosis1.47422411
58MP0005464_abnormal_platelet_physiology1.46455725
59MP0005167_abnormal_blood-brain_barrier1.45562560
60MP0003566_abnormal_cell_adhesion1.44030561
61MP0004185_abnormal_adipocyte_glucose1.43733799
62MP0002006_tumorigenesis1.39738989
63MP0009780_abnormal_chondrocyte_physiolo1.37630393
64MP0004947_skin_inflammation1.37561661
65MP0005310_abnormal_salivary_gland1.36824173
66MP0004264_abnormal_extraembryonic_tissu1.34302764
67MP0000716_abnormal_immune_system1.32209702
68MP0002419_abnormal_innate_immunity1.30848226
69MP0003633_abnormal_nervous_system1.26322523
70MP0003183_abnormal_peptide_metabolism1.25671816
71MP0003866_abnormal_defecation1.24162981
72MP0001486_abnormal_startle_reflex1.23815350
73MP0002272_abnormal_nervous_system1.23567507
74MP0001348_abnormal_lacrimal_gland1.23243763
75MP0006082_CNS_inflammation1.19982689
76MP0009278_abnormal_bone_marrow1.19956514
77MP0002148_abnormal_hypersensitivity_rea1.19237305
78MP0002733_abnormal_thermal_nociception1.17786867
79MP0002734_abnormal_mechanical_nocicepti1.17482935
80MP0003453_abnormal_keratinocyte_physiol1.16881566
81MP0003879_abnormal_hair_cell1.16174338
82MP0008874_decreased_physiological_sensi1.15958153
83MP0001873_stomach_inflammation1.15615907
84MP0001849_ear_inflammation1.15492092
85MP0001851_eye_inflammation1.15168464
86MP0003045_fibrosis1.15105586
87MP0010155_abnormal_intestine_physiology1.14133756
88MP0003448_altered_tumor_morphology1.09059495
89MP0001970_abnormal_pain_threshold1.08333791
90MP0005166_decreased_susceptibility_to1.08137611
91MP0005076_abnormal_cell_differentiation1.06769135
92MP0002998_abnormal_bone_remodeling1.06233932
93MP0002722_abnormal_immune_system1.05787891
94MP0000689_abnormal_spleen_morphology1.05106862
95MP0005397_hematopoietic_system_phenotyp1.04720644
96MP0001545_abnormal_hematopoietic_system1.04720644
97MP0000703_abnormal_thymus_morphology1.04189615
98MP0002396_abnormal_hematopoietic_system1.04182981
99* MP0008469_abnormal_protein_level1.02198447
100MP0000490_abnormal_crypts_of1.01730321
101MP0005621_abnormal_cell_physiology1.01654576
102MP0003828_pulmonary_edema1.00728257
103* MP0002429_abnormal_blood_cell0.99814979
104MP0001853_heart_inflammation0.98669066
105MP0002736_abnormal_nociception_after0.98400331
106MP0004924_abnormal_behavior0.97720669
107MP0005386_behavior/neurological_phenoty0.97720669
108MP0005058_abnormal_lysosome_morphology0.97683795
109MP0005409_darkened_coat_color0.97087089
110MP0002405_respiratory_system_inflammati0.95844289
111MP0002735_abnormal_chemical_nociception0.95414577
112MP0003690_abnormal_glial_cell0.94668731
113MP0003091_abnormal_cell_migration0.93228562
114MP0002067_abnormal_sensory_capabilities0.92352577
115MP0000465_gastrointestinal_hemorrhage0.92024449
116MP0001845_abnormal_inflammatory_respons0.91367855
117MP0010307_abnormal_tumor_latency0.90999529
118MP0001440_abnormal_grooming_behavior0.90907111
119MP0005174_abnormal_tail_pigmentation0.89109767
120MP0003631_nervous_system_phenotype0.88038019
121MP0008872_abnormal_physiological_respon0.87160371
122MP0003221_abnormal_cardiomyocyte_apopto0.84027354
123MP0010352_gastrointestinal_tract_polyps0.82758742
124* MP0004808_abnormal_hematopoietic_stem0.82707669
125MP0000955_abnormal_spinal_cord0.81007017
126MP0001730_embryonic_growth_arrest0.80981986
127MP0001915_intracranial_hemorrhage0.79779087
128MP0002557_abnormal_social/conspecific_i0.79446152
129MP0002019_abnormal_tumor_incidence0.77086249
130MP0002066_abnormal_motor_capabilities/c0.75664080
131MP0002254_reproductive_system_inflammat0.75552182
132MP0000350_abnormal_cell_proliferation0.74940616
133MP0004885_abnormal_endolymph0.73147142
134MP0004233_abnormal_muscle_weight0.72464662
135MP0002796_impaired_skin_barrier0.70818185
136MP0005666_abnormal_adipose_tissue0.67486817
137MP0004883_abnormal_blood_vessel0.66769233
138MP0003656_abnormal_erythrocyte_physiolo0.65808359
139MP0002132_abnormal_respiratory_system0.65670489
140MP0009763_increased_sensitivity_to0.64125294
141MP0001216_abnormal_epidermal_layer0.62704101
142MP0005384_cellular_phenotype0.61838579
143MP0005023_abnormal_wound_healing0.60014510

Predicted human phenotypes

RankGene SetZ-score
1Visual hallucinations (HP:0002367)4.02848181
2Myokymia (HP:0002411)3.98839654
3Papilledema (HP:0001085)3.68240843
4Focal motor seizures (HP:0011153)3.62070536
5Orchitis (HP:0100796)3.56995480
6Chronic otitis media (HP:0000389)3.45928076
7Focal seizures (HP:0007359)3.44008688
8Retrobulbar optic neuritis (HP:0100654)3.37948997
9Optic neuritis (HP:0100653)3.37948997
10Abnormality of macrophages (HP:0004311)3.15449595
11Supranuclear gaze palsy (HP:0000605)3.14538439
12Gingivitis (HP:0000230)3.14064364
13Hyperacusis (HP:0010780)3.06634758
14Meningitis (HP:0001287)2.97576523
15Gastrointestinal infarctions (HP:0005244)2.94822344
16Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.88524455
17Hemiplegia (HP:0002301)2.84171209
18Recurrent skin infections (HP:0001581)2.79709990
19Recurrent gram-negative bacterial infections (HP:0005420)2.78684832
20Subacute progressive viral hepatitis (HP:0006572)2.69938200
21Mutism (HP:0002300)2.66099904
22Recurrent bronchitis (HP:0002837)2.65169204
23Pointed chin (HP:0000307)2.65017960
24Abnormality of the lower motor neuron (HP:0002366)2.60750891
25Depression (HP:0000716)2.59207509
26Urinary bladder sphincter dysfunction (HP:0002839)2.59176399
27Dysmetric saccades (HP:0000641)2.57027864
28Recurrent viral infections (HP:0004429)2.56517027
29Postural instability (HP:0002172)2.56024152
30Keratoconjunctivitis sicca (HP:0001097)2.55679903
31Ankle clonus (HP:0011448)2.51228324
32Abnormal social behavior (HP:0012433)2.50342212
33Impaired social interactions (HP:0000735)2.50342212
34Eczematoid dermatitis (HP:0000976)2.49908575
35Genetic anticipation (HP:0003743)2.49179409
36Elevated erythrocyte sedimentation rate (HP:0003565)2.49143279
37Action tremor (HP:0002345)2.48495339
38Poor eye contact (HP:0000817)2.46881429
39Spontaneous hematomas (HP:0007420)2.46830210
40Viral hepatitis (HP:0006562)2.45964837
41Recurrent fungal infections (HP:0002841)2.45261060
42Autoimmune thrombocytopenia (HP:0001973)2.41300257
43Impaired vibration sensation in the lower limbs (HP:0002166)2.41108667
44Abnormality of binocular vision (HP:0011514)2.40072447
45Diplopia (HP:0000651)2.40072447
46Macroorchidism (HP:0000053)2.39589503
47Pulmonary infiltrates (HP:0002113)2.39138629
48Annular pancreas (HP:0001734)2.38338208
49Impaired smooth pursuit (HP:0007772)2.38073020
50Gastrointestinal stroma tumor (HP:0100723)2.38038275
51Encephalitis (HP:0002383)2.36229926
52Urinary urgency (HP:0000012)2.36190699
53Apathy (HP:0000741)2.35714512
54Osteomyelitis (HP:0002754)2.34154961
55Progressive cerebellar ataxia (HP:0002073)2.33531459
56Nasal polyposis (HP:0100582)2.32587037
57Urticaria (HP:0001025)2.32430705
58Increased cerebral lipofuscin (HP:0011813)2.32059677
59Recurrent cutaneous fungal infections (HP:0011370)2.31560843
60Chronic mucocutaneous candidiasis (HP:0002728)2.31560843
61Slow saccadic eye movements (HP:0000514)2.30321564
62Insomnia (HP:0100785)2.29503776
63Abnormal delayed hypersensitivity skin test (HP:0002963)2.28866872
64Diminished motivation (HP:0000745)2.28003796
65Abnormality of T cells (HP:0002843)2.27400006
66Abnormality of cells of the lymphoid lineage (HP:0012140)2.27303069
67Arterial thrombosis (HP:0004420)2.27058856
68Cellulitis (HP:0100658)2.24531500
69Autoimmune hemolytic anemia (HP:0001890)2.24296853
70Chronic obstructive pulmonary disease (HP:0006510)2.23964540
71Obstructive lung disease (HP:0006536)2.23964540
72Keratoconjunctivitis (HP:0001096)2.23093541
73Amyotrophic lateral sclerosis (HP:0007354)2.23064275
74Myositis (HP:0100614)2.22622648
75Lymphopenia (HP:0001888)2.21584939
76Colitis (HP:0002583)2.20758210
77Stereotypic behavior (HP:0000733)2.19346045
78Hemoptysis (HP:0002105)2.17387483
79Febrile seizures (HP:0002373)2.14600501
80Absence seizures (HP:0002121)2.14253892
81Abnormality of the nasal mucosa (HP:0000433)2.14193388
82Abnormality of ocular smooth pursuit (HP:0000617)2.13727454
83Inappropriate behavior (HP:0000719)2.12004231
84Recurrent abscess formation (HP:0002722)2.11947334
85Agammaglobulinemia (HP:0004432)2.11805518
86Truncal ataxia (HP:0002078)2.09734184
87Mediastinal lymphadenopathy (HP:0100721)2.08206211
88Atonic seizures (HP:0010819)2.07797922
89Micronodular cirrhosis (HP:0001413)2.07794780
90Epileptic encephalopathy (HP:0200134)2.07188813
91Abnormality of the fingertips (HP:0001211)2.05229323
92Increased IgM level (HP:0003496)2.03387965
93Metaphyseal cupping (HP:0003021)2.01742157
94Asymmetry of the thorax (HP:0001555)2.01603839
95Gastrointestinal inflammation (HP:0004386)2.00447779
96Resting tremor (HP:0002322)2.00130250
97Recurrent bacterial skin infections (HP:0005406)1.99661756
98Gingival bleeding (HP:0000225)1.98818477
99Abnormality of the periventricular white matter (HP:0002518)1.98300681
100Broad face (HP:0000283)1.97518893
101Cheilitis (HP:0100825)1.97482851
102Syringomyelia (HP:0003396)1.97345848
103Spinal cord lesions (HP:0100561)1.97345848
104Frequent falls (HP:0002359)1.96434397
105Upper limb amyotrophy (HP:0009129)1.96166995
106Distal upper limb amyotrophy (HP:0007149)1.96166995
107Abnormality of the peritoneum (HP:0002585)1.95923889
108Inflammation of the large intestine (HP:0002037)1.95597366
109Abnormality of T cell number (HP:0011839)1.94803552
110Absent frontal sinuses (HP:0002688)1.94078634
111Striae distensae (HP:0001065)1.93842070
112Abnormal eating behavior (HP:0100738)1.93336493
113Chronic sinusitis (HP:0011109)1.93329758
114T lymphocytopenia (HP:0005403)1.91922924
115Gaze-evoked nystagmus (HP:0000640)1.91711696
116Elfin facies (HP:0004428)1.91172849
117Cerebral aneurysm (HP:0004944)1.91172184
118Abnormality of T cell physiology (HP:0011840)1.89920326
119Flat acetabular roof (HP:0003180)1.89642026
120Abnormality of oral frenula (HP:0000190)1.88608778
121Granulocytopenia (HP:0001913)1.88233488
122Dialeptic seizures (HP:0011146)1.88033948
123Hand muscle atrophy (HP:0009130)1.87281694
124Stomatitis (HP:0010280)1.87188763
125Hypochromic anemia (HP:0001931)1.87122751
126Bradykinesia (HP:0002067)1.86867623
127Skin ulcer (HP:0200042)1.86832505
128Abnormality of the endocardium (HP:0004306)1.86730956
129Neuronal loss in central nervous system (HP:0002529)1.86546446
130Segmental peripheral demyelination/remyelination (HP:0003481)1.85985710
131Hypergammaglobulinemia (HP:0010702)1.85777929
132Lower limb amyotrophy (HP:0007210)1.85513474
133Spastic gait (HP:0002064)1.84909341
134IgM deficiency (HP:0002850)1.84763817
135Generalized tonic-clonic seizures (HP:0002069)1.84716416
136Broad-based gait (HP:0002136)1.84635274
137Chest pain (HP:0100749)1.83198904
138Papilloma (HP:0012740)1.82920609
139Verrucae (HP:0200043)1.82920609
140Increased IgE level (HP:0003212)1.82851946
141Spinal canal stenosis (HP:0003416)1.81312751
142Panhypogammaglobulinemia (HP:0003139)1.80263270
143Fatigue (HP:0012378)1.80025192
144Vasculitis (HP:0002633)1.79830231
145Premature loss of primary teeth (HP:0006323)1.79609493
146Periodontitis (HP:0000704)1.79171693
147Ankyloglossia (HP:0010296)1.79046492
148Torticollis (HP:0000473)1.78607542
149Dysmetria (HP:0001310)1.78460039
150Interstitial pulmonary disease (HP:0006530)1.77437501
151Pulmonary embolism (HP:0002204)1.77125017
152Emphysema (HP:0002097)1.75780210
153Pustule (HP:0200039)1.75374223
154Sepsis (HP:0100806)1.74876306
155Peritonitis (HP:0002586)1.74802375
156Leukocytosis (HP:0001974)1.74785731
157IgA deficiency (HP:0002720)1.74188978
158Persistence of primary teeth (HP:0006335)1.70544713
159Dilatation of the ascending aorta (HP:0005111)1.67712003
160Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.67012288
161Osteolytic defects of the phalanges of the hand (HP:0009771)1.65718007
162Osteolytic defects of the hand bones (HP:0009699)1.65718007
163Deep philtrum (HP:0002002)1.65494472
164Abnormality of the pleura (HP:0002103)1.65284479
165Polygenic inheritance (HP:0010982)1.64706695
166Hepatitis (HP:0012115)1.63954081
167Epistaxis (HP:0000421)1.61444328
168Glomerulopathy (HP:0100820)1.61101668

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.82058402
2SMG12.71218415
3MAP3K132.68969234
4RIPK42.63191262
5SIK22.55740678
6NTRK32.51250673
7MAP4K12.44895748
8DAPK22.27272312
9KSR22.16499053
10IRAK42.07944049
11JAK12.00195458
12CAMKK11.99812403
13EPHA41.99796441
14EPHB11.97626466
15FES1.89133851
16TYK21.86143481
17IKBKE1.82376572
18MARK11.82299781
19MAP2K31.79831952
20PAK61.77016894
21TRIB31.73535623
22ALK1.72437506
23TAOK11.69375993
24JAK31.68382891
25EEF2K1.67762884
26MAP3K41.64943479
27RIPK11.63596338
28PRKD31.62214073
29MINK11.59906029
30PRKCH1.58968183
31PKN21.57992262
32NTRK21.56825315
33TBK11.55493160
34KIT1.45376825
35SCYL21.44977443
36FGFR41.37305713
37DAPK11.36491898
38ICK1.35198275
39SIK11.31294997
40YES11.27416512
41MAP3K141.26258140
42SGK31.25940575
43FGFR31.23607244
44IRAK31.18335158
45MAP3K101.18088622
46STK381.16155352
47TYRO31.12691134
48HCK1.12381764
49SYK1.10432181
50FGR1.09026730
51ERN11.07053048
52CDK51.05971441
53RET1.05112837
54MAP3K31.05054131
55IRAK11.04412577
56KSR11.01143468
57TNK21.00508849
58MAP3K70.99280329
59JAK20.96360157
60NTRK10.96333892
61BRD40.96044724
62PDK10.95920517
63GRK60.94847893
64IRAK20.92482530
65RAF10.88995661
66TXK0.87397586
67ZAP700.86266280
68MARK20.79133673
69MAP3K20.78943220
70STK110.78838691
71MAPK110.77945538
72CDK40.77142859
73MAP2K40.75684534
74PRKD20.75276147
75SIK30.75176438
76MAP2K70.74868928
77STK100.74619956
78CAMK1G0.72814748
79SGK20.72336800
80CAMKK20.72331167
81LYN0.70392452
82CDK60.70360964
83PTK60.68271220
84TAOK20.67366238
85EPHA30.66993879
86BMX0.66599031
87MTOR0.65805091
88MAP3K10.64811054
89CDK120.64342786
90LCK0.64121174
91LRRK20.64108900
92PASK0.63522074
93FYN0.63389300
94MATK0.63114071
95MAP3K120.62993679
96NLK0.61427873
97RPS6KB20.61417199
98PDPK10.60392813
99MELK0.59236370
100CAMK10.58550353
101CSF1R0.57470786
102WNK10.56827626
103ITK0.56241436
104NEK90.55809410
105BLK0.55439613
106RPS6KA20.54829701
107BMPR20.53141096
108SGK10.52937674
109LMTK20.52932962
110BTK0.51052358
111CSK0.50878282
112MAP3K80.50546498
113CAMK40.49074782
114CLK10.48191510
115HIPK20.48077962
116PAK40.45239219
117CAMK1D0.43845211
118CHUK0.43771674
119CDC42BPA0.43563827
120NEK60.43302541
121MARK30.43164781
122ARAF0.43136952
123IKBKB0.42932590
124CDK190.42517582
125TTN0.41258452
126RPS6KA30.40486902
127PDGFRA0.38295367
128PRPF4B0.37622882
129DMPK0.37559304
130PRKCG0.37478837
131MAP3K60.37439906
132SGK4940.36189892
133SGK2230.36189892
134PDGFRB0.36148892
135SRC0.35429259
136MAPK100.35324368
137EGFR0.33786282
138MAPK80.33030404

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.06775786
2Olfactory transduction_Homo sapiens_hsa047401.99105886
3Long-term potentiation_Homo sapiens_hsa047201.76050434
4Circadian entrainment_Homo sapiens_hsa047131.62540681
5Nicotine addiction_Homo sapiens_hsa050331.60950808
6B cell receptor signaling pathway_Homo sapiens_hsa046621.60837021
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.59555727
8Autoimmune thyroid disease_Homo sapiens_hsa053201.53793220
9Morphine addiction_Homo sapiens_hsa050321.53724572
10Graft-versus-host disease_Homo sapiens_hsa053321.49543029
11GABAergic synapse_Homo sapiens_hsa047271.48988955
12Type II diabetes mellitus_Homo sapiens_hsa049301.47173536
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44374092
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.42802502
15Glutamatergic synapse_Homo sapiens_hsa047241.42332168
16Staphylococcus aureus infection_Homo sapiens_hsa051501.42170600
17Salivary secretion_Homo sapiens_hsa049701.41621499
18Primary immunodeficiency_Homo sapiens_hsa053401.39751962
19Osteoclast differentiation_Homo sapiens_hsa043801.38864317
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.37035230
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.36265421
22Gastric acid secretion_Homo sapiens_hsa049711.36042421
23Cholinergic synapse_Homo sapiens_hsa047251.33648793
24Neurotrophin signaling pathway_Homo sapiens_hsa047221.32049569
25Chemokine signaling pathway_Homo sapiens_hsa040621.30351315
26T cell receptor signaling pathway_Homo sapiens_hsa046601.30109373
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.28667598
28Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27319800
29Leishmaniasis_Homo sapiens_hsa051401.26454343
30Thyroid cancer_Homo sapiens_hsa052161.25683378
31Renal cell carcinoma_Homo sapiens_hsa052111.25560249
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24328268
33Amphetamine addiction_Homo sapiens_hsa050311.24316344
34Dopaminergic synapse_Homo sapiens_hsa047281.23760720
35Glioma_Homo sapiens_hsa052141.22858312
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.20994043
37Viral myocarditis_Homo sapiens_hsa054161.18022666
38Notch signaling pathway_Homo sapiens_hsa043301.16920012
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16334222
40Prostate cancer_Homo sapiens_hsa052151.16308926
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15649749
42Oxytocin signaling pathway_Homo sapiens_hsa049211.15130362
43Type I diabetes mellitus_Homo sapiens_hsa049401.14397082
44GnRH signaling pathway_Homo sapiens_hsa049121.12393584
45Insulin secretion_Homo sapiens_hsa049111.11795856
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11401998
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.10033444
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08459483
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08194523
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06468220
51VEGF signaling pathway_Homo sapiens_hsa043701.05626669
52mTOR signaling pathway_Homo sapiens_hsa041501.03983595
53Estrogen signaling pathway_Homo sapiens_hsa049151.03425323
54Non-small cell lung cancer_Homo sapiens_hsa052231.02299794
55Viral carcinogenesis_Homo sapiens_hsa052031.01336149
56Chronic myeloid leukemia_Homo sapiens_hsa052201.01307485
57Malaria_Homo sapiens_hsa051440.99446029
58Tuberculosis_Homo sapiens_hsa051520.99299016
59Other glycan degradation_Homo sapiens_hsa005110.99264256
60* Measles_Homo sapiens_hsa051620.98376034
61Prolactin signaling pathway_Homo sapiens_hsa049170.98341530
62Legionellosis_Homo sapiens_hsa051340.98161122
63Renin secretion_Homo sapiens_hsa049240.97623727
64Nitrogen metabolism_Homo sapiens_hsa009100.97553253
65Long-term depression_Homo sapiens_hsa047300.96249057
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94454564
67Cocaine addiction_Homo sapiens_hsa050300.93484333
68TNF signaling pathway_Homo sapiens_hsa046680.92305321
69* Influenza A_Homo sapiens_hsa051640.92255251
70ErbB signaling pathway_Homo sapiens_hsa040120.91847626
71Dorso-ventral axis formation_Homo sapiens_hsa043200.91486279
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.91356000
73Platelet activation_Homo sapiens_hsa046110.90851358
74Epstein-Barr virus infection_Homo sapiens_hsa051690.90451602
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90376777
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89998592
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.89284325
78Small cell lung cancer_Homo sapiens_hsa052220.86950267
79cAMP signaling pathway_Homo sapiens_hsa040240.86887959
80Endometrial cancer_Homo sapiens_hsa052130.85441442
81Bladder cancer_Homo sapiens_hsa052190.85340865
82Toxoplasmosis_Homo sapiens_hsa051450.85326683
83Gap junction_Homo sapiens_hsa045400.85021986
84Hepatitis B_Homo sapiens_hsa051610.84508958
85Acute myeloid leukemia_Homo sapiens_hsa052210.84468145
86Pancreatic cancer_Homo sapiens_hsa052120.84020299
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83805178
88Colorectal cancer_Homo sapiens_hsa052100.83639300
89MAPK signaling pathway_Homo sapiens_hsa040100.82410822
90HTLV-I infection_Homo sapiens_hsa051660.82005828
91Calcium signaling pathway_Homo sapiens_hsa040200.81363339
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.81051218
93Hematopoietic cell lineage_Homo sapiens_hsa046400.80989159
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80800797
95FoxO signaling pathway_Homo sapiens_hsa040680.80231992
96Endocytosis_Homo sapiens_hsa041440.79845452
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78586163
98Salmonella infection_Homo sapiens_hsa051320.77928797
99MicroRNAs in cancer_Homo sapiens_hsa052060.77542915
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76282496
101Shigellosis_Homo sapiens_hsa051310.75331764
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73306656
103Allograft rejection_Homo sapiens_hsa053300.72074886
104Insulin resistance_Homo sapiens_hsa049310.70662093
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.69849685
106Antigen processing and presentation_Homo sapiens_hsa046120.69155647
107Choline metabolism in cancer_Homo sapiens_hsa052310.69044543
108Intestinal immune network for IgA production_Homo sapiens_hsa046720.68907924
109Hepatitis C_Homo sapiens_hsa051600.68875825
110African trypanosomiasis_Homo sapiens_hsa051430.68448116
111Insulin signaling pathway_Homo sapiens_hsa049100.68092167
112HIF-1 signaling pathway_Homo sapiens_hsa040660.68053889
113Pertussis_Homo sapiens_hsa051330.67435193
114Adherens junction_Homo sapiens_hsa045200.67235139
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67186398
116Inositol phosphate metabolism_Homo sapiens_hsa005620.67086928
117Proteoglycans in cancer_Homo sapiens_hsa052050.66640845
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.65878601
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65647127
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.65379906
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64360985
122Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63884989
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61403519
124Amoebiasis_Homo sapiens_hsa051460.61342055
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61092716
126Rap1 signaling pathway_Homo sapiens_hsa040150.60970702
127Phagosome_Homo sapiens_hsa041450.60617121
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59252294
129Herpes simplex infection_Homo sapiens_hsa051680.59174211
130Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58258522
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57731467
132Apoptosis_Homo sapiens_hsa042100.57472199
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51205939
134Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45236365
135Asthma_Homo sapiens_hsa053100.44584572
136Prion diseases_Homo sapiens_hsa050200.43782818

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