ADARB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.27999320
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.26085086
3locomotory exploration behavior (GO:0035641)6.02043271
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.78487674
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.56205696
6vocalization behavior (GO:0071625)5.28172411
7glutamate secretion (GO:0014047)5.09630197
8synaptic vesicle exocytosis (GO:0016079)5.08261034
9regulation of synaptic vesicle exocytosis (GO:2000300)5.04953050
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.03456293
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.88197176
12neurotransmitter secretion (GO:0007269)4.75893328
13neuronal action potential propagation (GO:0019227)4.75327888
14gamma-aminobutyric acid transport (GO:0015812)4.70925609
15regulation of glutamate receptor signaling pathway (GO:1900449)4.65211307
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.60828897
17regulation of synaptic vesicle transport (GO:1902803)4.49310778
18cellular potassium ion homeostasis (GO:0030007)4.41193958
19sodium ion export (GO:0071436)4.40646234
20exploration behavior (GO:0035640)4.27541644
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.25534292
22regulation of neuronal synaptic plasticity (GO:0048168)4.25454837
23layer formation in cerebral cortex (GO:0021819)4.17320323
24regulation of synapse structural plasticity (GO:0051823)4.16839139
25synaptic transmission, glutamatergic (GO:0035249)4.10816585
26protein localization to synapse (GO:0035418)4.09753294
27membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.09560453
28cerebellar Purkinje cell differentiation (GO:0021702)4.04982814
29glutamate receptor signaling pathway (GO:0007215)4.04204805
30cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.97207380
31long-term memory (GO:0007616)3.95839468
32dendritic spine morphogenesis (GO:0060997)3.88979331
33neuromuscular process controlling posture (GO:0050884)3.85994525
34neurotransmitter-gated ion channel clustering (GO:0072578)3.85775910
35glycine transport (GO:0015816)3.84957040
36neurotransmitter transport (GO:0006836)3.84529158
37neuron-neuron synaptic transmission (GO:0007270)3.84084244
38proline transport (GO:0015824)3.80141456
39activation of protein kinase A activity (GO:0034199)3.77764548
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.76727457
41neuromuscular process controlling balance (GO:0050885)3.67519014
42peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.64856722
43cell communication by electrical coupling (GO:0010644)3.64670875
44positive regulation of membrane potential (GO:0045838)3.63237385
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.61850862
46neuron cell-cell adhesion (GO:0007158)3.59654446
47regulation of neurotransmitter levels (GO:0001505)3.53847302
48cell-substrate junction assembly (GO:0007044)3.50884464
49positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.49826713
50regulation of postsynaptic membrane potential (GO:0060078)3.45766518
51regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.43921713
52hemidesmosome assembly (GO:0031581)3.39047540
53regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.38099613
54potassium ion import (GO:0010107)3.37886219
55membrane depolarization during action potential (GO:0086010)3.37212948
56positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.36656502
57regulation of neurotransmitter secretion (GO:0046928)3.36281813
58positive regulation of synapse maturation (GO:0090129)3.35018993
59transmission of nerve impulse (GO:0019226)3.34838641
60regulation of ARF protein signal transduction (GO:0032012)3.33751354
61synaptic vesicle endocytosis (GO:0048488)3.31432082
62regulation of synaptic plasticity (GO:0048167)3.30524205
63cerebellar granule cell differentiation (GO:0021707)3.30133798
64auditory behavior (GO:0031223)3.28228922
65focal adhesion assembly (GO:0048041)3.27119432
66cell-substrate adherens junction assembly (GO:0007045)3.27119432
67G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.24861739
68prepulse inhibition (GO:0060134)3.23645139
69gamma-aminobutyric acid signaling pathway (GO:0007214)3.23348603
70regulation of dendritic spine morphogenesis (GO:0061001)3.21691414
71cytoskeletal anchoring at plasma membrane (GO:0007016)3.17836888
72positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.17727550
73dendrite morphogenesis (GO:0048813)3.17333414
74regulation of synaptic transmission, glutamatergic (GO:0051966)3.15737400
75response to auditory stimulus (GO:0010996)3.13668512
76vesicle transport along microtubule (GO:0047496)3.12417619
77regulation of neurotransmitter transport (GO:0051588)3.12267429
78adherens junction assembly (GO:0034333)3.11640947
79membrane hyperpolarization (GO:0060081)3.09647002
80membrane depolarization (GO:0051899)3.09605930
81positive regulation of synaptic transmission, GABAergic (GO:0032230)3.09297374
82potassium ion homeostasis (GO:0055075)3.08651318
83L-amino acid import (GO:0043092)3.07075938
84regulation of vesicle fusion (GO:0031338)3.06920062
85neuronal ion channel clustering (GO:0045161)3.05921792
86long-term synaptic potentiation (GO:0060291)3.05391397
87response to pheromone (GO:0019236)3.03126235
88cellular sodium ion homeostasis (GO:0006883)3.02207534
89regulation of clathrin-mediated endocytosis (GO:2000369)3.01983974
90neuromuscular process (GO:0050905)3.01479736
91positive regulation of fibroblast migration (GO:0010763)3.00939039
92neuron recognition (GO:0008038)2.98014744
93positive regulation of potassium ion transmembrane transport (GO:1901381)2.93497565
94positive regulation of neurotransmitter transport (GO:0051590)2.93365587
95negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.91631466
96adult walking behavior (GO:0007628)2.91503431
97protein localization to endosome (GO:0036010)2.91401342
98negative regulation of synaptic transmission, GABAergic (GO:0032229)2.91292385
99negative regulation of erythrocyte differentiation (GO:0045647)2.90203274
100cerebellar Purkinje cell layer development (GO:0021680)2.89627533
101cell differentiation in hindbrain (GO:0021533)2.89615566
102insulin-like growth factor receptor signaling pathway (GO:0048009)2.89158430
103regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88470116
104mating behavior (GO:0007617)2.87773889
105establishment of nucleus localization (GO:0040023)2.87595357
106regulation of calcium ion-dependent exocytosis (GO:0017158)2.86840670
107regulation of early endosome to late endosome transport (GO:2000641)2.86648479
108regulation of voltage-gated calcium channel activity (GO:1901385)2.85320157
109synaptic transmission (GO:0007268)2.84485853
110positive regulation of neurotransmitter secretion (GO:0001956)2.84129213
111long term synaptic depression (GO:0060292)2.83722275
112chemosensory behavior (GO:0007635)2.83174168
113basement membrane organization (GO:0071711)2.80620943
114kidney mesenchyme development (GO:0072074)2.80251592
115positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.79722936
116regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.75050362
117stress fiber assembly (GO:0043149)2.72005684
118protein targeting to plasma membrane (GO:0072661)2.68498556
119metanephric mesenchyme development (GO:0072075)2.68449314
120extracellular matrix assembly (GO:0085029)2.63743577
121collagen fibril organization (GO:0030199)2.62550100
122negative regulation of fatty acid transport (GO:2000192)2.60432634
123mannose metabolic process (GO:0006013)2.60318793
124cell migration involved in heart development (GO:0060973)2.57783438
125positive regulation of myotube differentiation (GO:0010831)2.56205969
126positive regulation of receptor recycling (GO:0001921)2.55616431
127cell adhesion mediated by integrin (GO:0033627)2.52101886
128endodermal cell differentiation (GO:0035987)2.51519616
129cortical actin cytoskeleton organization (GO:0030866)2.51473842
130vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.50863951
131positive regulation of blood vessel endothelial cell migration (GO:0043536)2.50718235
132atrioventricular valve morphogenesis (GO:0003181)2.50172474
133neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.45832946
134cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.41975913
135response to laminar fluid shear stress (GO:0034616)2.38131136
136venous blood vessel morphogenesis (GO:0048845)2.33445842
137regulation of ARF GTPase activity (GO:0032312)2.27135967
138response to fluid shear stress (GO:0034405)2.25376714
139amino acid import (GO:0043090)2.24099002
140pericardium development (GO:0060039)2.20147165
141regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.20056487
142cortical cytoskeleton organization (GO:0030865)2.19245489
143surfactant homeostasis (GO:0043129)2.19206002
144extracellular fibril organization (GO:0043206)2.19141399
145regulation of synapse maturation (GO:0090128)2.17986469
146barbed-end actin filament capping (GO:0051016)2.17033176
147positive regulation of CREB transcription factor activity (GO:0032793)2.16919622
148G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.15252853
149signal complex assembly (GO:0007172)2.13587829
150clathrin coat assembly (GO:0048268)2.13563947
151negative regulation of vascular permeability (GO:0043116)2.12360983
152positive regulation of Rap GTPase activity (GO:0032854)2.12282470
153positive regulation of protein dephosphorylation (GO:0035307)2.10311873
154regulation of NFAT protein import into nucleus (GO:0051532)2.08139524
155plasma membrane repair (GO:0001778)2.06752528
156embryonic viscerocranium morphogenesis (GO:0048703)2.05072549
157semaphorin-plexin signaling pathway (GO:0071526)2.04568930
158glomerular basement membrane development (GO:0032836)2.03660278
159regulation of Rap GTPase activity (GO:0032317)2.02943759
160regulation of T-helper 2 cell differentiation (GO:0045628)2.02883338
161positive regulation of histone deacetylation (GO:0031065)2.02066153
162cell volume homeostasis (GO:0006884)2.00329188
163vascular endothelial growth factor signaling pathway (GO:0038084)2.00308253
164retina vasculature morphogenesis in camera-type eye (GO:0061299)2.00259727
165regulation of anoikis (GO:2000209)1.98798623
166neuromuscular junction development (GO:0007528)1.98552061
167endothelial cell chemotaxis (GO:0035767)1.98348121
168fibril organization (GO:0097435)1.98345161
169negative regulation of cell size (GO:0045792)1.97290670
170hypotonic response (GO:0006971)1.97155519
171positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)1.96920671
172cellular response to catecholamine stimulus (GO:0071870)1.96793776
173cellular response to monoamine stimulus (GO:0071868)1.96793776

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.73158001
2* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.94413066
3GBX2_23144817_ChIP-Seq_PC3_Human2.94392384
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.91040072
5DROSHA_22980978_ChIP-Seq_HELA_Human2.88913453
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.76031805
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.68345707
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65702917
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65702917
10REST_21632747_ChIP-Seq_MESCs_Mouse2.65048295
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.58202514
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.54791954
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.51144185
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50612804
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.50220251
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48761016
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47777215
18* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37836692
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34531232
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33295144
21ESR2_21235772_ChIP-Seq_MCF-7_Human2.29519169
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.28472527
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.26652700
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.22257745
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.21086813
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.17661596
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.15861219
28* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13166920
29RNF2_27304074_Chip-Seq_ESCs_Mouse2.07828561
30EED_16625203_ChIP-ChIP_MESCs_Mouse2.05676128
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01185370
32KDM2B_26808549_Chip-Seq_DND41_Human2.00111369
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95127891
34LXR_22292898_ChIP-Seq_THP-1_Human1.92945362
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.91469558
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.89787651
37* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.89321436
38RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.89195869
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.88996403
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77248428
41AR_21572438_ChIP-Seq_LNCaP_Human1.74360081
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70810843
43TCF7_22412390_ChIP-Seq_EML_Mouse1.68613308
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.68272325
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58962749
46* KDM2B_26808549_Chip-Seq_JURKAT_Human1.57953567
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.54418137
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53963709
49SMAD4_21799915_ChIP-Seq_A2780_Human1.51884976
50P300_27058665_Chip-Seq_ZR-75-30cells_Human1.44137315
51* RACK7_27058665_Chip-Seq_MCF-7_Human1.41468245
52DNAJC2_21179169_ChIP-ChIP_NT2_Human1.40324583
53* KDM2B_26808549_Chip-Seq_K562_Human1.38653595
54CLOCK_20551151_ChIP-Seq_293T_Human1.37797007
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35395994
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.35369525
57RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.34911302
58SOX9_24532713_ChIP-Seq_HFSC_Mouse1.34319929
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34229977
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34218695
61AR_19668381_ChIP-Seq_PC3_Human1.31919515
62MYC_22102868_ChIP-Seq_BL_Human1.30993371
63UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30804743
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.30067004
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.29985166
66SMC4_20622854_ChIP-Seq_HELA_Human1.29558949
67STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28262090
68ZNF274_21170338_ChIP-Seq_K562_Hela1.28122616
69TBX20_22328084_ChIP-Seq_HEART_Mouse1.26405445
70TBX20_22080862_ChIP-Seq_HEART_Mouse1.26405445
71* RING1B_27294783_Chip-Seq_ESCs_Mouse1.26121930
72* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25853980
73* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25820712
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24906317
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24395859
76VDR_21846776_ChIP-Seq_THP-1_Human1.24342782
77TP53_23651856_ChIP-Seq_MEFs_Mouse1.23655336
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21002463
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20835031
80CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20003930
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19493142
82WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18728685
83NFIB_24661679_ChIP-Seq_LUNG_Mouse1.18635994
84SMC1_22415368_ChIP-Seq_MEFs_Mouse1.17821575
85STAT3_23295773_ChIP-Seq_U87_Human1.17250745
86ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17182132
87ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16914885
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13718324
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10925166
90* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10852709
91* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.08773997
92AR_25329375_ChIP-Seq_VCAP_Human1.05817676
93* RING1B_27294783_Chip-Seq_NPCs_Mouse1.05277528
94ZNF263_19887448_ChIP-Seq_K562_Human1.05249028
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04992222
96UBF1/2_26484160_Chip-Seq_HMECs_Human1.04901251
97SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04541534
98CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03693228
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.03350405
100YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02487398
101CREB1_26743006_Chip-Seq_LNCaP_Human1.02310910
102CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01980860
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01644996
104ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01065832
105TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00849790
106AHR_22903824_ChIP-Seq_MCF-7_Human1.00812672
107RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00726612
108TP53_22127205_ChIP-Seq_IMR90_Human1.00704538
109TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00250714
110TCF4_23295773_ChIP-Seq_U87_Human0.99814781
111ARNT_22903824_ChIP-Seq_MCF-7_Human0.99677440
112TAF15_26573619_Chip-Seq_HEK293_Human0.99541017
113SMAD4_21741376_ChIP-Seq_HESCs_Human0.98241343
114PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98175701
115* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97838995
116CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96936866
117RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96710332
118ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96637613
119EGR1_19374776_ChIP-ChIP_THP-1_Human0.96160672
120TP53_20018659_ChIP-ChIP_R1E_Mouse0.96002842
121SMAD3_21741376_ChIP-Seq_HESCs_Human0.95509811
122MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95450741
123THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94788990
124DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94702071
125P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94560682
126TET1_21490601_ChIP-Seq_MESCs_Mouse0.94326562
127CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93660072
128RXR_22108803_ChIP-Seq_LS180_Human0.93188273
129* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92984559
130TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92766487
131ESR1_21235772_ChIP-Seq_MCF-7_Human0.92417030
132SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92055965
133GATA1_19941827_ChIP-Seq_MEL_Mouse0.91964346
134* PIAS1_25552417_ChIP-Seq_VCAP_Human0.91889291
135CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91812854
136SMAD3_21741376_ChIP-Seq_ESCs_Human0.91503473
137EP300_21415370_ChIP-Seq_HL-1_Mouse0.91388137
138RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91310987
139VDR_24763502_ChIP-Seq_THP-1_Human0.91209268
140TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91063426
141KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90857557
142P300_19829295_ChIP-Seq_ESCs_Human0.90839178
143OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89908191
144TP53_16413492_ChIP-PET_HCT116_Human0.89648226
145TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88451648
146SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88115809
147CTCF_27219007_Chip-Seq_Bcells_Human0.87501491
148NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87198643
149* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85965853
150* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85229480
151SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84042109
152ESR1_20079471_ChIP-ChIP_T-47D_Human0.82732271
153* KLF4_19829295_ChIP-Seq_ESCs_Human0.82725588
154SMAD4_21741376_ChIP-Seq_EPCs_Human0.82703392

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.73445238
2MP0008438_abnormal_cutaneous_collagen5.28387504
3MP0003705_abnormal_hypodermis_morpholog5.00411216
4MP0003880_abnormal_central_pattern4.28784419
5* MP0003635_abnormal_synaptic_transmissio4.20697351
6MP0009046_muscle_twitch3.63566594
7MP0001958_emphysema3.51515788
8MP0004270_analgesia3.50404304
9MP0009745_abnormal_behavioral_response3.38637619
10* MP0002064_seizures3.19224857
11MP0002063_abnormal_learning/memory/cond3.18475596
12MP0003279_aneurysm3.06254550
13MP0005275_abnormal_skin_tensile3.04373352
14MP0005423_abnormal_somatic_nervous2.99784694
15MP0001968_abnormal_touch/_nociception2.79442817
16MP0002272_abnormal_nervous_system2.73714708
17MP0002822_catalepsy2.65659346
18MP0002572_abnormal_emotion/affect_behav2.63294659
19MP0002734_abnormal_mechanical_nocicepti2.60466952
20MP0005503_abnormal_tendon_morphology2.58141093
21MP0001486_abnormal_startle_reflex2.49750666
22MP0001501_abnormal_sleep_pattern2.46026471
23MP0001348_abnormal_lacrimal_gland2.43331517
24MP0008569_lethality_at_weaning2.36041858
25MP0005409_darkened_coat_color2.31632775
26MP0004272_abnormal_basement_membrane2.30401254
27MP0003566_abnormal_cell_adhesion2.21932623
28MP0002909_abnormal_adrenal_gland2.17524953
29MP0009780_abnormal_chondrocyte_physiolo2.14221023
30MP0003091_abnormal_cell_migration2.03429919
31MP0002067_abnormal_sensory_capabilities1.99869723
32MP0001440_abnormal_grooming_behavior1.98868306
33MP0002736_abnormal_nociception_after1.93865789
34MP0002733_abnormal_thermal_nociception1.86342463
35MP0002735_abnormal_chemical_nociception1.85930192
36MP0001970_abnormal_pain_threshold1.84907606
37MP0003329_amyloid_beta_deposits1.82927166
38MP0004858_abnormal_nervous_system1.80675962
39MP0004811_abnormal_neuron_physiology1.71875769
40MP0004924_abnormal_behavior1.67010267
41MP0005386_behavior/neurological_phenoty1.67010267
42MP0002557_abnormal_social/conspecific_i1.64771528
43MP0004885_abnormal_endolymph1.62701636
44MP0002108_abnormal_muscle_morphology1.62693042
45MP0000733_abnormal_muscle_development1.62277097
46* MP0002184_abnormal_innervation1.61741495
47MP0003950_abnormal_plasma_membrane1.57242701
48MP0000767_abnormal_smooth_muscle1.54882508
49MP0005646_abnormal_pituitary_gland1.54652588
50MP0003633_abnormal_nervous_system1.50351427
51MP0003879_abnormal_hair_cell1.49082930
52* MP0000955_abnormal_spinal_cord1.48586413
53MP0004145_abnormal_muscle_electrophysio1.48403053
54MP0002877_abnormal_melanocyte_morpholog1.47332992
55MP0000579_abnormal_nail_morphology1.46026415
56MP0005595_abnormal_vascular_smooth1.45687285
57MP0005076_abnormal_cell_differentiation1.45127289
58MP0005257_abnormal_intraocular_pressure1.43519022
59* MP0000759_abnormal_skeletal_muscle1.42130982
60MP0002295_abnormal_pulmonary_circulatio1.41594021
61* MP0002066_abnormal_motor_capabilities/c1.41315532
62MP0003283_abnormal_digestive_organ1.41040517
63MP0010368_abnormal_lymphatic_system1.39767145
64MP0003787_abnormal_imprinting1.39628098
65MP0003303_peritoneal_inflammation1.38969512
66MP0002060_abnormal_skin_morphology1.38205383
67MP0000751_myopathy1.36290363
68* MP0002882_abnormal_neuron_morphology1.33535009
69MP0001984_abnormal_olfaction1.32907639
70MP0000013_abnormal_adipose_tissue1.32519866
71MP0000778_abnormal_nervous_system1.32284879
72MP0001502_abnormal_circadian_rhythm1.30980358
73MP0001849_ear_inflammation1.30360144
74MP0004142_abnormal_muscle_tone1.29665517
75MP0005058_abnormal_lysosome_morphology1.29323564
76MP0002089_abnormal_postnatal_growth/wei1.29299837
77MP0008961_abnormal_basal_metabolism1.26256419
78MP0005023_abnormal_wound_healing1.25756860
79MP0000749_muscle_degeneration1.25215153
80MP0003631_nervous_system_phenotype1.23299667
81MP0002133_abnormal_respiratory_system1.22250518
82MP0005388_respiratory_system_phenotype1.22250518
83MP0008260_abnormal_autophagy1.19492737
84MP0003690_abnormal_glial_cell1.15570698
85MP0009384_cardiac_valve_regurgitation1.15474461
86MP0005551_abnormal_eye_electrophysiolog1.14539959
87* MP0004087_abnormal_muscle_fiber1.13259855
88MP0005645_abnormal_hypothalamus_physiol1.12456532
89MP0006276_abnormal_autonomic_nervous1.11836989
90MP0001542_abnormal_bone_strength1.09154609
91MP0001177_atelectasis1.07636778
92MP0006138_congestive_heart_failure1.06360548
93MP0000569_abnormal_digit_pigmentation1.04985293
94MP0002896_abnormal_bone_mineralization1.04541366
95MP0003122_maternal_imprinting1.03061212
96MP0002837_dystrophic_cardiac_calcinosis1.02476255
97* MP0002229_neurodegeneration1.00931661
98MP0002152_abnormal_brain_morphology1.00826634
99MP0005167_abnormal_blood-brain_barrier1.00707505
100MP0003828_pulmonary_edema0.99629788
101MP0008872_abnormal_physiological_respon0.99612856
102MP0005375_adipose_tissue_phenotype0.99356898
103MP0004215_abnormal_myocardial_fiber0.98751551
104MP0008874_decreased_physiological_sensi0.98500531
105MP0001851_eye_inflammation0.98130883
106MP0003632_abnormal_nervous_system0.96127748
107MP0004085_abnormal_heartbeat0.96006553
108MP0003075_altered_response_to0.95393827
109MP0003453_abnormal_keratinocyte_physiol0.95349375
110MP0004381_abnormal_hair_follicle0.94975820
111MP0003763_abnormal_thymus_physiology0.94772179
112MP0002933_joint_inflammation0.92888213
113MP0002998_abnormal_bone_remodeling0.90503623
114MP0005535_abnormal_body_temperature0.89095989
115MP0005171_absent_coat_pigmentation0.88922214
116MP0002069_abnormal_eating/drinking_beha0.88850154
117MP0005508_abnormal_skeleton_morphology0.88716926
118MP0000750_abnormal_muscle_regeneration0.87581688
119MP0004036_abnormal_muscle_relaxation0.85642046
120MP0004043_abnormal_pH_regulation0.85335808
121MP0002332_abnormal_exercise_endurance0.84420400
122MP0003634_abnormal_glial_cell0.84009730
123MP0002090_abnormal_vision0.83618137
124MP0003191_abnormal_cellular_cholesterol0.82721170
125MP0001299_abnormal_eye_distance/0.82710648
126MP0004510_myositis0.81689489
127MP0005623_abnormal_meninges_morphology0.81221608
128MP0000920_abnormal_myelination0.81214153
129MP0003137_abnormal_impulse_conducting0.80743851
130MP0001879_abnormal_lymphatic_vessel0.80424161
131MP0010630_abnormal_cardiac_muscle0.80394545
132MP0004233_abnormal_muscle_weight0.80320879
133MP0004742_abnormal_vestibular_system0.79209789
134MP0003045_fibrosis0.78741168
135MP0000604_amyloidosis0.78495119
136MP0005451_abnormal_body_composition0.75734723
137MP0004185_abnormal_adipocyte_glucose0.72190211
138MP0004130_abnormal_muscle_cell0.71871068
139MP0001188_hyperpigmentation0.71545665
140MP0003300_gastrointestinal_ulcer0.70982586
141MP0010386_abnormal_urinary_bladder0.70555312
142MP0000747_muscle_weakness0.70071076
143MP0010030_abnormal_orbit_morphology0.69938010
144MP0004484_altered_response_of0.69841770
145MP0003115_abnormal_respiratory_system0.69775319
146MP0005621_abnormal_cell_physiology0.67077388
147MP0002128_abnormal_blood_circulation0.65905486
148MP0006054_spinal_hemorrhage0.65849844
149MP0003172_abnormal_lysosome_physiology0.65305152
150MP0001905_abnormal_dopamine_level0.65282344
151MP0002638_abnormal_pupillary_reflex0.65102963
152MP0000534_abnormal_ureter_morphology0.64963416
153MP0005369_muscle_phenotype0.64739874
154MP0004134_abnormal_chest_morphology0.62512561
155MP0004084_abnormal_cardiac_muscle0.62233831
156MP0001963_abnormal_hearing_physiology0.62229225
157MP0005187_abnormal_penis_morphology0.59246545
158* MP0002752_abnormal_somatic_nervous0.59018162
159MP0005394_taste/olfaction_phenotype0.58956199
160MP0005499_abnormal_olfactory_system0.58956199
161MP0000003_abnormal_adipose_tissue0.56579398
162MP0001529_abnormal_vocalization0.56272964
163MP0006072_abnormal_retinal_apoptosis0.56082445
164MP0001485_abnormal_pinna_reflex0.55688498
165* MP0010769_abnormal_survival0.55273276
166MP0001943_abnormal_respiration0.53751133

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.22913877
2Myokymia (HP:0002411)6.36034295
3Focal seizures (HP:0007359)5.56217545
4Visual hallucinations (HP:0002367)5.54045608
5Action tremor (HP:0002345)4.80275457
6Progressive cerebellar ataxia (HP:0002073)4.61571258
7Protrusio acetabuli (HP:0003179)4.45015879
8Premature rupture of membranes (HP:0001788)4.30207384
9Atonic seizures (HP:0010819)4.18640739
10Febrile seizures (HP:0002373)4.16180676
11Epileptic encephalopathy (HP:0200134)4.12248116
12Cerebral aneurysm (HP:0004944)4.09640482
13Absence seizures (HP:0002121)3.89578631
14Aortic aneurysm (HP:0004942)3.81413948
15Generalized tonic-clonic seizures (HP:0002069)3.69545209
16Dysdiadochokinesis (HP:0002075)3.65676507
17Gaze-evoked nystagmus (HP:0000640)3.62447438
18Supranuclear gaze palsy (HP:0000605)3.52684275
19Aortic dissection (HP:0002647)3.50114684
20Poor eye contact (HP:0000817)3.44252375
21Ankle clonus (HP:0011448)3.43721737
22Dialeptic seizures (HP:0011146)3.41518487
23Depression (HP:0000716)3.37480185
24Hemiplegia (HP:0002301)3.35907862
25Impaired vibration sensation in the lower limbs (HP:0002166)3.35401773
26Broad-based gait (HP:0002136)3.33992325
27Postural instability (HP:0002172)3.30907308
28Urinary bladder sphincter dysfunction (HP:0002839)3.29595484
29Dysmetric saccades (HP:0000641)3.29389113
30Abnormal social behavior (HP:0012433)3.22031776
31Impaired social interactions (HP:0000735)3.22031776
32Truncal ataxia (HP:0002078)3.20777034
33Impaired smooth pursuit (HP:0007772)3.20699439
34Vascular tortuosity (HP:0004948)3.20592717
35Dysmetria (HP:0001310)3.19831692
36Atrophic scars (HP:0001075)3.17251077
37Genetic anticipation (HP:0003743)3.15666955
38Abnormality of the lower motor neuron (HP:0002366)3.13634813
39Ventricular fibrillation (HP:0001663)3.12450921
40Scanning speech (HP:0002168)3.11588175
41Intention tremor (HP:0002080)3.07983310
42Papilledema (HP:0001085)3.05949616
43Arterial tortuosity (HP:0005116)3.01385125
44Shallow orbits (HP:0000586)3.00072708
45Anxiety (HP:0000739)2.98745839
46Abnormal eating behavior (HP:0100738)2.93092505
47Abnormality of ocular smooth pursuit (HP:0000617)2.85555007
48Mitral valve prolapse (HP:0001634)2.84265802
49Fragile skin (HP:0001030)2.78279103
50Mutism (HP:0002300)2.72772490
51Urinary urgency (HP:0000012)2.70070113
52Ulnar bowing (HP:0003031)2.68017695
53Hemiparesis (HP:0001269)2.65794216
54Torticollis (HP:0000473)2.64882566
55Annular pancreas (HP:0001734)2.64105387
56Bundle branch block (HP:0011710)2.62628423
57Status epilepticus (HP:0002133)2.62234416
58Spastic gait (HP:0002064)2.60379305
59Genu recurvatum (HP:0002816)2.58856093
60Dilatation of the ascending aorta (HP:0005111)2.57752979
61Bladder diverticulum (HP:0000015)2.56483219
62Diplopia (HP:0000651)2.55637293
63Abnormality of binocular vision (HP:0011514)2.55637293
64Mitral regurgitation (HP:0001653)2.52071115
65Overgrowth (HP:0001548)2.51792301
66Soft skin (HP:0000977)2.51586480
67Thin ribs (HP:0000883)2.50759495
68Broad face (HP:0000283)2.50377016
69Bradykinesia (HP:0002067)2.45972570
70Increased connective tissue (HP:0009025)2.45098950
71Insomnia (HP:0100785)2.43649130
72Wormian bones (HP:0002645)2.39742386
73Broad metatarsal (HP:0001783)2.36705991
74Focal dystonia (HP:0004373)2.36663816
75Pointed chin (HP:0000307)2.33651430
76Amblyopia (HP:0000646)2.31212798
77Agitation (HP:0000713)2.28437837
78Progressive inability to walk (HP:0002505)2.28061741
79Type 1 muscle fiber predominance (HP:0003803)2.28048356
80Stereotypic behavior (HP:0000733)2.26828627
81Impaired vibratory sensation (HP:0002495)2.26146649
82Aortic regurgitation (HP:0001659)2.26056698
83Aneurysm (HP:0002617)2.24521768
84Drooling (HP:0002307)2.23788723
85Excessive salivation (HP:0003781)2.23788723
86Abnormality of saccadic eye movements (HP:0000570)2.21264545
87Mild short stature (HP:0003502)2.20971416
88Increased variability in muscle fiber diameter (HP:0003557)2.20360797
89Lower limb muscle weakness (HP:0007340)2.19732513
90Tetraplegia (HP:0002445)2.19447875
91Disproportionate tall stature (HP:0001519)2.17963834
92Hyperventilation (HP:0002883)2.16412598
93Ulnar deviation of the wrist (HP:0003049)2.15471785
94Megalencephaly (HP:0001355)2.14792665
95Craniofacial dystonia (HP:0012179)2.12324420
96Blue sclerae (HP:0000592)2.11916104
97Clonus (HP:0002169)2.11904044
98Neurofibrillary tangles (HP:0002185)2.11763658
99Joint laxity (HP:0001388)2.11125497
100Abnormal EKG (HP:0003115)2.08248624
101Postural tremor (HP:0002174)2.07608551
102Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.07605428
103Hyperextensible skin (HP:0000974)2.07427507
104Pheochromocytoma (HP:0002666)2.07192700
105Cerebral inclusion bodies (HP:0100314)2.06600095
106Resting tremor (HP:0002322)2.06452013
107Dislocated radial head (HP:0003083)2.05764433
108Abnormality of the corticospinal tract (HP:0002492)2.05736445
109Epileptiform EEG discharges (HP:0011182)2.05683315
110EEG with generalized epileptiform discharges (HP:0011198)2.04319989
111Fetal akinesia sequence (HP:0001989)2.03510371
112Follicular hyperkeratosis (HP:0007502)2.02334299
113Lower limb asymmetry (HP:0100559)2.00801917
114Spondylolisthesis (HP:0003302)2.00385963
115Gait ataxia (HP:0002066)1.99378719
116Neuronal loss in central nervous system (HP:0002529)1.98829089
117Interstitial pulmonary disease (HP:0006530)1.98634330
118Hypsarrhythmia (HP:0002521)1.98124190
119Asymmetric septal hypertrophy (HP:0001670)1.98088976
120Thin bony cortex (HP:0002753)1.97789047
121Prolonged QT interval (HP:0001657)1.96592318
122Absent speech (HP:0001344)1.95928153
123Spinal rigidity (HP:0003306)1.95570833
124Ankle contracture (HP:0006466)1.94723464
125Lower limb amyotrophy (HP:0007210)1.93748799
126Cervical subluxation (HP:0003308)1.90751058
127Wide anterior fontanel (HP:0000260)1.90043715
128Elbow flexion contracture (HP:0002987)1.90011662
129Abnormality of the radial head (HP:0003995)1.88943410
130Insidious onset (HP:0003587)1.88534707
131Termporal pattern (HP:0011008)1.88534707
132Distal lower limb amyotrophy (HP:0008944)1.88519203
133Mildly elevated creatine phosphokinase (HP:0008180)1.87690296
134Rapidly progressive (HP:0003678)1.86126498
135Generalized myoclonic seizures (HP:0002123)1.83246365
136Vertebral arch anomaly (HP:0008438)1.81943023
137Obstructive sleep apnea (HP:0002870)1.81826705
138Asymmetry of the thorax (HP:0001555)1.81770442
139Horizontal nystagmus (HP:0000666)1.81361274
140Central scotoma (HP:0000603)1.80474618
141Hypoplasia of the iris (HP:0007676)1.80442348
142Rigidity (HP:0002063)1.79711605
143Macroorchidism (HP:0000053)1.79677462
144Short nail (HP:0001799)1.79324820
145Distal upper limb amyotrophy (HP:0007149)1.78893298
146Upper limb amyotrophy (HP:0009129)1.78893298
147Psychosis (HP:0000709)1.78456771
148Spinal canal stenosis (HP:0003416)1.78263725
149Round ear (HP:0100830)1.78192937
150Incomplete penetrance (HP:0003829)1.77531189
151Turricephaly (HP:0000262)1.77309514
152Abnormality of skeletal muscle fiber size (HP:0012084)1.77048719
153Vertebral compression fractures (HP:0002953)1.76165891
154Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.73846769
155Neoplasm of the heart (HP:0100544)1.73595114
156Camptodactyly of toe (HP:0001836)1.72883024
157Syncope (HP:0001279)1.71526821
158Abnormality of dentin (HP:0010299)1.71136839
159Hypoventilation (HP:0002791)1.70662526
160Osteolytic defects of the hand bones (HP:0009699)1.70607923
161Osteolytic defects of the phalanges of the hand (HP:0009771)1.70607923
162Ankyloglossia (HP:0010296)1.70220640
163Joint stiffness (HP:0001387)1.69968387
164Peritonitis (HP:0002586)1.69244611
165Hyperacusis (HP:0010780)1.68234627
166Ectopia lentis (HP:0001083)1.67369327
167Hyporeflexia of lower limbs (HP:0002600)1.66049691
168Biconcave vertebral bodies (HP:0004586)1.64764373
169Easy fatigability (HP:0003388)1.64721543
170Persistence of primary teeth (HP:0006335)1.64412575
171Milia (HP:0001056)1.63768459
172Achilles tendon contracture (HP:0001771)1.63571075
173Premature skin wrinkling (HP:0100678)1.60747511
174Abnormality of the calcaneus (HP:0008364)1.58455284
175Bowel diverticulosis (HP:0005222)1.58346652
176Bowed forearm bones (HP:0003956)1.56005475
177Bowing of the arm (HP:0006488)1.56005475
178Distal lower limb muscle weakness (HP:0009053)1.55443229
179Spinal cord compression (HP:0002176)1.55339504
180Mucopolysacchariduria (HP:0008155)1.55151706
181Urinary glycosaminoglycan excretion (HP:0003541)1.55151706
182Slow saccadic eye movements (HP:0000514)1.55058543
183Abnormality of the neuromuscular junction (HP:0003398)1.54600936
184Fatigable weakness (HP:0003473)1.54600936
185Slender build (HP:0001533)1.53960215

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.51837118
2MAP3K93.82191714
3EPHA43.50649706
4MAP3K42.97101607
5ICK2.76769074
6MARK12.49724912
7PAK62.48522445
8MINK12.48424190
9DAPK22.47358376
10PRKD32.42757434
11CAMKK12.41265239
12NTRK22.32497136
13MAP2K72.14590761
14TTN2.12574879
15NTRK12.07251385
16EEF2K2.05870987
17MAP2K42.01921690
18STK382.01465912
19KSR21.95429979
20SIK11.73209362
21CAMKK21.72204562
22CDK121.69247490
23CAMK1D1.67536911
24RIPK11.61341204
25ERN11.58967256
26RIPK41.56027715
27CDK51.51485808
28MUSK1.51462182
29TGFBR21.49809382
30MAP2K31.48523273
31MAPK121.39861704
32PDK21.38857486
33SMG11.37343299
34PRKCH1.35413889
35MAP3K111.33624164
36SIK21.31922662
37MAP3K21.24965644
38TNIK1.24551465
39GRK51.23097122
40PKN21.22993785
41TYRO31.21883567
42MAP3K121.21774627
43KSR11.19502024
44ALK1.17842961
45WNK11.17615923
46PRKCG1.17383333
47DAPK11.16873663
48PINK11.16485260
49TAOK11.13918271
50UHMK11.11971357
51PHKG21.11567022
52PHKG11.11567022
53CDK191.10601600
54PRPF4B1.10527945
55CAMK11.10082279
56FES1.09161923
57MTOR1.07393425
58SGK2231.05092239
59SGK4941.05092239
60SGK31.03063197
61IRAK31.01890315
62STK111.01222456
63MAP3K131.00736907
64PNCK1.00285955
65RET1.00279737
66PDGFRB0.99305024
67PLK20.99262226
68SGK20.98318827
69LATS20.96423370
70LMTK20.93004902
71MAP3K60.92571708
72FGFR40.92262788
73CAMK1G0.91719924
74PIM20.91127888
75PTK20.89710988
76FGFR20.89698875
77MAP3K70.86602992
78PAK20.86331184
79MAPK130.85983292
80CDC42BPA0.85823042
81MAPK70.85750881
82MOS0.84964221
83CAMK2A0.81389585
84MAP3K30.80897374
85CDK150.80523242
86PAK30.79409009
87CDK180.78678410
88PDK10.77668594
89SCYL20.77001972
90SGK10.75035330
91MARK20.74422469
92MAPKAPK50.73292221
93ZAP700.73110070
94CDK140.72210416
95PDPK10.72176371
96ARAF0.71283196
97MAPK40.71232064
98MAP3K10.71222530
99CAMK40.70894313
100TNK20.70024223
101TRIB30.68872424
102CDK11A0.68220172
103TAOK20.68180273
104MYLK0.64905020
105PDGFRA0.64368887
106NEK10.63010819
107NEK90.62991864
108RPS6KA30.62255122
109FGFR30.60826338
110MELK0.60276306
111MAPKAPK30.60241458
112MAPK110.60027455
113CAMK2B0.59922530
114DYRK1A0.56626805
115HIPK20.56217370
116JAK10.56065041
117MAPK100.54180149
118CASK0.53941837
119LATS10.53426152
120RAF10.53249705
121PRKD10.52438073
122PTK60.52298713
123NEK60.51962364
124CAMK2G0.51093607
125CAMK2D0.49868457
126PTK2B0.49420923
127RPS6KC10.49352461
128RPS6KL10.49352461
129DMPK0.49207350
130FER0.49046311
131EPHB10.48594596
132PRKCZ0.48485453
133FYN0.48434756
134TRPM70.47075826
135OXSR10.47019187
136CSNK1G20.46147355
137DDR20.41790952
138PRKCE0.38455483
139BRSK10.37793540
140ROCK20.35995575
141PRKCB0.35858919
142BMPR20.33490865
143RPS6KA20.32544861
144MAPK80.31629025
145BMX0.31478113
146PRKD20.30954307

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.45104838
2Synaptic vesicle cycle_Homo sapiens_hsa047213.14884378
3GABAergic synapse_Homo sapiens_hsa047272.70553127
4Circadian entrainment_Homo sapiens_hsa047132.61220649
5Olfactory transduction_Homo sapiens_hsa047402.56543196
6Long-term potentiation_Homo sapiens_hsa047202.54577130
7Glutamatergic synapse_Homo sapiens_hsa047242.52291676
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.47981870
9Morphine addiction_Homo sapiens_hsa050322.36526937
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.26679600
11Amphetamine addiction_Homo sapiens_hsa050312.24859365
12Nitrogen metabolism_Homo sapiens_hsa009102.11738282
13Salivary secretion_Homo sapiens_hsa049702.10442971
14Insulin secretion_Homo sapiens_hsa049112.08844078
15Dopaminergic synapse_Homo sapiens_hsa047281.98843862
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.93577044
17Gastric acid secretion_Homo sapiens_hsa049711.90362599
18Cholinergic synapse_Homo sapiens_hsa047251.81323307
19ECM-receptor interaction_Homo sapiens_hsa045121.75523295
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70672871
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.69106223
22Taste transduction_Homo sapiens_hsa047421.68884616
23Long-term depression_Homo sapiens_hsa047301.66943405
24Focal adhesion_Homo sapiens_hsa045101.60883643
25Cocaine addiction_Homo sapiens_hsa050301.58702804
26Oxytocin signaling pathway_Homo sapiens_hsa049211.57628239
27Renin secretion_Homo sapiens_hsa049241.57427296
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.57210123
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.50861898
30Calcium signaling pathway_Homo sapiens_hsa040201.48522041
31Type II diabetes mellitus_Homo sapiens_hsa049301.47107292
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45093794
33Chronic myeloid leukemia_Homo sapiens_hsa052201.42211084
34GnRH signaling pathway_Homo sapiens_hsa049121.41515684
35Amoebiasis_Homo sapiens_hsa051461.38727032
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37028374
37Serotonergic synapse_Homo sapiens_hsa047261.34424051
38cAMP signaling pathway_Homo sapiens_hsa040241.28676462
39Gap junction_Homo sapiens_hsa045401.25349280
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22750879
41Small cell lung cancer_Homo sapiens_hsa052221.20946465
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20863683
43Estrogen signaling pathway_Homo sapiens_hsa049151.20464854
44Acute myeloid leukemia_Homo sapiens_hsa052211.19572631
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.15033181
46Proteoglycans in cancer_Homo sapiens_hsa052051.11688929
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08889436
48Glioma_Homo sapiens_hsa052141.03084833
49Pancreatic cancer_Homo sapiens_hsa052121.02719460
50Phototransduction_Homo sapiens_hsa047441.01697893
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99801378
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98370925
53Pancreatic secretion_Homo sapiens_hsa049720.94356695
54Dilated cardiomyopathy_Homo sapiens_hsa054140.93216397
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91989013
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.90996425
57Notch signaling pathway_Homo sapiens_hsa043300.90822667
58Melanogenesis_Homo sapiens_hsa049160.90674731
59Platelet activation_Homo sapiens_hsa046110.90338375
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.90259072
61Thyroid hormone synthesis_Homo sapiens_hsa049180.89573130
62Osteoclast differentiation_Homo sapiens_hsa043800.89569138
63ErbB signaling pathway_Homo sapiens_hsa040120.89249009
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89234628
65Adherens junction_Homo sapiens_hsa045200.88737471
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.87839551
67Dorso-ventral axis formation_Homo sapiens_hsa043200.87817852
68Collecting duct acid secretion_Homo sapiens_hsa049660.86204813
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85586213
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85094398
71B cell receptor signaling pathway_Homo sapiens_hsa046620.84449047
72Bile secretion_Homo sapiens_hsa049760.83269332
73Cardiac muscle contraction_Homo sapiens_hsa042600.82091855
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81434516
75Other glycan degradation_Homo sapiens_hsa005110.80399968
76Axon guidance_Homo sapiens_hsa043600.80207093
77Bladder cancer_Homo sapiens_hsa052190.79309824
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79303033
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79127627
80Colorectal cancer_Homo sapiens_hsa052100.78839861
81Thyroid cancer_Homo sapiens_hsa052160.78023133
82Prostate cancer_Homo sapiens_hsa052150.77891822
83Prolactin signaling pathway_Homo sapiens_hsa049170.77651049
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.75631324
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75345517
86Toxoplasmosis_Homo sapiens_hsa051450.74728371
87MicroRNAs in cancer_Homo sapiens_hsa052060.74641545
88TNF signaling pathway_Homo sapiens_hsa046680.74212536
89Malaria_Homo sapiens_hsa051440.73237802
90T cell receptor signaling pathway_Homo sapiens_hsa046600.72911052
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70971875
92Oocyte meiosis_Homo sapiens_hsa041140.70558786
93FoxO signaling pathway_Homo sapiens_hsa040680.70456982
94Melanoma_Homo sapiens_hsa052180.69209186
95MAPK signaling pathway_Homo sapiens_hsa040100.68406832
96Glucagon signaling pathway_Homo sapiens_hsa049220.67150099
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65959825
98Choline metabolism in cancer_Homo sapiens_hsa052310.64382354
99mTOR signaling pathway_Homo sapiens_hsa041500.63646415
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.62313795
101Arginine biosynthesis_Homo sapiens_hsa002200.62041794
102Circadian rhythm_Homo sapiens_hsa047100.58749434
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58035275
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57783312
105Inositol phosphate metabolism_Homo sapiens_hsa005620.57597919
106Vibrio cholerae infection_Homo sapiens_hsa051100.56722697
107Type I diabetes mellitus_Homo sapiens_hsa049400.55463696
108VEGF signaling pathway_Homo sapiens_hsa043700.54594042
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53989143
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50466587
111Rap1 signaling pathway_Homo sapiens_hsa040150.50397577
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49775731
113Endocytosis_Homo sapiens_hsa041440.49680188
114Insulin signaling pathway_Homo sapiens_hsa049100.48401417
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47678518
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47407564
117Ras signaling pathway_Homo sapiens_hsa040140.46337233
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46322340
119Fatty acid biosynthesis_Homo sapiens_hsa000610.41159291
120Prion diseases_Homo sapiens_hsa050200.40870049
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.40356848
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39666707
123Ovarian steroidogenesis_Homo sapiens_hsa049130.39547136
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38444518
125Alcoholism_Homo sapiens_hsa050340.37780309
126Non-small cell lung cancer_Homo sapiens_hsa052230.37326539
127Endometrial cancer_Homo sapiens_hsa052130.37263902
128Renal cell carcinoma_Homo sapiens_hsa052110.34902539
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33090822
130Chemokine signaling pathway_Homo sapiens_hsa040620.30805874
131Wnt signaling pathway_Homo sapiens_hsa043100.30336907
132Butanoate metabolism_Homo sapiens_hsa006500.30196822
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.30143350
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.29120992
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28778960

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