ADARB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the double-stranded RNA adenosine deaminase family of RNA-editing enzymes and may play a regulatory role in RNA editing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)6.90506757
2regulation of gene silencing by miRNA (GO:0060964)6.90506757
3regulation of gene silencing by RNA (GO:0060966)6.90506757
4synaptic vesicle maturation (GO:0016188)6.32453972
5pre-miRNA processing (GO:0031054)5.95334199
6synaptic vesicle docking involved in exocytosis (GO:0016081)5.88603830
7glutamate secretion (GO:0014047)5.82800977
8nuclear pore organization (GO:0006999)5.63389230
9regulation of nuclear cell cycle DNA replication (GO:0033262)5.56144022
10regulation of short-term neuronal synaptic plasticity (GO:0048172)5.52433680
11synaptic vesicle exocytosis (GO:0016079)5.50494239
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.45124861
13membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.31083515
14axon ensheathment in central nervous system (GO:0032291)5.28707072
15central nervous system myelination (GO:0022010)5.28707072
16nuclear pore complex assembly (GO:0051292)5.20757406
17postsynaptic membrane organization (GO:0001941)5.02797839
18regulation of synaptic vesicle exocytosis (GO:2000300)4.90852839
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.85707169
20neurotransmitter secretion (GO:0007269)4.80292593
21vocalization behavior (GO:0071625)4.76215673
22protein localization to synapse (GO:0035418)4.68037316
23gamma-aminobutyric acid transport (GO:0015812)4.58860296
24neuron cell-cell adhesion (GO:0007158)4.53792890
25neurotransmitter-gated ion channel clustering (GO:0072578)4.52418681
26synaptic transmission, glutamatergic (GO:0035249)4.46651520
27locomotory exploration behavior (GO:0035641)4.44175317
28neuronal action potential propagation (GO:0019227)4.42994910
29DNA replication-dependent nucleosome organization (GO:0034723)4.39362292
30DNA replication-dependent nucleosome assembly (GO:0006335)4.39362292
31regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.39271717
32regulation of helicase activity (GO:0051095)4.38023221
33positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.34605691
34regulation of synaptic vesicle transport (GO:1902803)4.32147046
35folic acid-containing compound biosynthetic process (GO:0009396)4.31412311
36L-amino acid import (GO:0043092)4.27832110
37presynaptic membrane organization (GO:0097090)4.25714614
38regulation of histone H3-K9 methylation (GO:0051570)4.25356543
39IMP biosynthetic process (GO:0006188)4.23670372
40negative regulation of synaptic transmission, GABAergic (GO:0032229)4.21933962
41DNA replication initiation (GO:0006270)4.21289009
42presynaptic membrane assembly (GO:0097105)4.19924057
43cellular potassium ion homeostasis (GO:0030007)4.17115951
44regulation of synapse structural plasticity (GO:0051823)4.17113299
45positive regulation of synapse maturation (GO:0090129)4.16783560
46regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.16333941
47DNA unwinding involved in DNA replication (GO:0006268)4.12295558
48regulation of neuronal synaptic plasticity (GO:0048168)4.10709831
49mitotic metaphase plate congression (GO:0007080)4.06052276
50glutamate receptor signaling pathway (GO:0007215)4.04567654
51paraxial mesoderm development (GO:0048339)4.03622199
52transmission of nerve impulse (GO:0019226)3.99335396
53negative regulation of histone methylation (GO:0031061)3.97348301
54positive regulation of DNA-dependent DNA replication (GO:2000105)3.95611452
55exploration behavior (GO:0035640)3.95532878
56regulation of glutamate receptor signaling pathway (GO:1900449)3.92188263
57neuronal ion channel clustering (GO:0045161)3.91242130
58regulation of telomere maintenance via telomerase (GO:0032210)3.88300709
59neurotransmitter transport (GO:0006836)3.88151715
60neuron-neuron synaptic transmission (GO:0007270)3.88140292
61pore complex assembly (GO:0046931)3.87681661
62regulation of gene silencing (GO:0060968)3.86179128
63protein K6-linked ubiquitination (GO:0085020)3.84907852
64membrane depolarization during action potential (GO:0086010)3.83953157
65cerebellar granule cell differentiation (GO:0021707)3.82692903
66amino acid import (GO:0043090)3.81907098
67nucleobase biosynthetic process (GO:0046112)3.81139741
68kinetochore organization (GO:0051383)3.79943244
69positive regulation of membrane potential (GO:0045838)3.76095311
70chromatin remodeling at centromere (GO:0031055)3.74668776
71somatic diversification of immune receptors via somatic mutation (GO:0002566)3.74411421
72somatic hypermutation of immunoglobulin genes (GO:0016446)3.74411421
73regulation of excitatory postsynaptic membrane potential (GO:0060079)3.73207590
74regulation of long-term neuronal synaptic plasticity (GO:0048169)3.72329548
75regulation of neurotransmitter levels (GO:0001505)3.71722023
76sodium ion export (GO:0071436)3.71662111
77mitotic nuclear envelope disassembly (GO:0007077)3.68797455
78auditory behavior (GO:0031223)3.68402982
79dendritic spine morphogenesis (GO:0060997)3.67431037
80protein localization to kinetochore (GO:0034501)3.67115060
81mitotic sister chromatid segregation (GO:0000070)3.66988941
82kinetochore assembly (GO:0051382)3.66847622
83neuromuscular synaptic transmission (GO:0007274)3.64463015
84regulation of neurotransmitter secretion (GO:0046928)3.62993347
85ncRNA catabolic process (GO:0034661)3.60080645
86positive regulation of dendritic spine development (GO:0060999)3.59800738
87metaphase plate congression (GO:0051310)3.59782801
88cerebellar Purkinje cell differentiation (GO:0021702)3.59690104
89peptidyl-arginine omega-N-methylation (GO:0035247)3.58966536
90gamma-aminobutyric acid signaling pathway (GO:0007214)3.57743869
91potassium ion import (GO:0010107)3.53680764
92regulation of postsynaptic membrane potential (GO:0060078)3.53140774
93IMP metabolic process (GO:0046040)3.51559328
94histone arginine methylation (GO:0034969)3.50051454
95regulation of synapse maturation (GO:0090128)3.49461415
96regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.48574103
97regulation of centriole replication (GO:0046599)3.48515858
98regulation of centrosome cycle (GO:0046605)3.47798003
99CENP-A containing nucleosome assembly (GO:0034080)3.45889505
100membrane depolarization (GO:0051899)3.44910432
101DNA strand elongation involved in DNA replication (GO:0006271)3.44341654
102membrane disassembly (GO:0030397)3.44159094
103nuclear envelope disassembly (GO:0051081)3.44159094
104regulation of neurotransmitter transport (GO:0051588)3.43759124
105regulation of voltage-gated calcium channel activity (GO:1901385)3.38402279
106DNA geometric change (GO:0032392)3.38060790
107DNA duplex unwinding (GO:0032508)3.36849697
108sister chromatid segregation (GO:0000819)3.35567291
109ribosome biogenesis (GO:0042254)3.33122166
110microtubule depolymerization (GO:0007019)3.32274869
111regulation of vesicle fusion (GO:0031338)3.31673449
112ribosome assembly (GO:0042255)3.27327843
113DNA strand elongation (GO:0022616)3.27129963
114DNA replication-independent nucleosome assembly (GO:0006336)3.24853242
115DNA replication-independent nucleosome organization (GO:0034724)3.24853242
116purine nucleobase biosynthetic process (GO:0009113)3.24129525
117telomere maintenance via semi-conservative replication (GO:0032201)3.23924719
118proline transport (GO:0015824)3.23655050
119histone H4-K12 acetylation (GO:0043983)3.23479366
120regulation of synaptic transmission, glutamatergic (GO:0051966)3.23186804
121ribosomal large subunit biogenesis (GO:0042273)3.22631699
122long-term memory (GO:0007616)3.21704635
123regulation of dendritic spine development (GO:0060998)3.20322392
124response to auditory stimulus (GO:0010996)3.18003166
125adult walking behavior (GO:0007628)3.16498694
126regulation of centrosome duplication (GO:0010824)3.16446884
127protein localization to chromosome, centromeric region (GO:0071459)3.16096958
128histone exchange (GO:0043486)3.15061014
129DNA replication checkpoint (GO:0000076)3.14531076
130positive regulation of neurotransmitter transport (GO:0051590)3.14343647
131positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.14077732
132positive regulation of neurotransmitter secretion (GO:0001956)3.13762182
133peptidyl-arginine methylation (GO:0018216)3.13397818
134peptidyl-arginine N-methylation (GO:0035246)3.13397818
135maturation of SSU-rRNA (GO:0030490)3.13084047
136regulation of synaptic plasticity (GO:0048167)3.12953685
137synaptic vesicle endocytosis (GO:0048488)3.12225739
138positive regulation of chromosome segregation (GO:0051984)3.09683980
139neurotransmitter uptake (GO:0001504)3.09179556
140cell migration in hindbrain (GO:0021535)3.07099342
141synaptic transmission (GO:0007268)3.07087638
142startle response (GO:0001964)3.06404848
143pyrimidine nucleobase catabolic process (GO:0006208)3.06192694
144acidic amino acid transport (GO:0015800)3.05638653
145regulation of translational fidelity (GO:0006450)3.03967439
146positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.03913980
147ribonucleoprotein complex biogenesis (GO:0022613)3.02393726
148regulation of DNA-dependent DNA replication (GO:0090329)3.01819973
149establishment of chromosome localization (GO:0051303)3.01655235
150phosphorelay signal transduction system (GO:0000160)3.01244161
151cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.01207596
152establishment of integrated proviral latency (GO:0075713)3.01188438
153regulation of dendritic spine morphogenesis (GO:0061001)3.00518059
154potassium ion homeostasis (GO:0055075)2.99897343
155anterior/posterior axis specification, embryo (GO:0008595)2.99651481
156regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.99178662
157G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.98399978
158cell differentiation in hindbrain (GO:0021533)2.97283472
159regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.96578831
160telomere maintenance via telomere lengthening (GO:0010833)2.95696962
161positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.95358078
162positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.95358078
163positive regulation of mitotic sister chromatid separation (GO:1901970)2.95358078
164mismatch repair (GO:0006298)2.94927736
165mitotic recombination (GO:0006312)2.94238668
166heterochromatin organization (GO:0070828)2.93054494
167nucleobase catabolic process (GO:0046113)2.92828744
168neuromuscular process controlling balance (GO:0050885)2.92091128
169telomere maintenance via recombination (GO:0000722)2.91818550
170chromatin assembly or disassembly (GO:0006333)2.91075750
171maturation of 5.8S rRNA (GO:0000460)2.90839231
172intra-S DNA damage checkpoint (GO:0031573)2.90815153
173regulation of synaptic transmission (GO:0050804)2.90726904
174regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.90589490
175negative regulation of chromosome segregation (GO:0051985)2.90394860
176meiotic chromosome segregation (GO:0045132)2.88346269
177regulation of sister chromatid segregation (GO:0033045)2.87907463
178regulation of mitotic sister chromatid separation (GO:0010965)2.87907463
179regulation of mitotic sister chromatid segregation (GO:0033047)2.87907463
180positive regulation of SMAD protein import into nucleus (GO:0060391)2.87419889
181spliceosomal snRNP assembly (GO:0000387)2.87363578
182negative regulation of DNA-dependent DNA replication (GO:2000104)2.86880783
183DNA strand renaturation (GO:0000733)2.86783310
184negative regulation of chromatin modification (GO:1903309)2.86717506
185mitotic sister chromatid cohesion (GO:0007064)2.86062331
186spindle checkpoint (GO:0031577)2.85510979
187negative regulation of cytosolic calcium ion concentration (GO:0051481)2.84728439
188regulation of chromosome segregation (GO:0051983)2.84384818
189regulation of respiratory gaseous exchange (GO:0043576)2.84129407
190synapse assembly (GO:0007416)2.83927414
191mechanosensory behavior (GO:0007638)2.83758480
192maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.83500547
193serotonin metabolic process (GO:0042428)2.83410262
194long-term synaptic potentiation (GO:0060291)2.83270186
195rRNA processing (GO:0006364)2.83136864
196establishment of mitochondrion localization (GO:0051654)2.82698382
197regulation of mitotic metaphase/anaphase transition (GO:0030071)2.82538602
198intraspecies interaction between organisms (GO:0051703)2.82479506
199chromatin assembly (GO:0031497)2.82410134
200negative regulation of mitotic sister chromatid segregation (GO:0033048)2.81879275

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.61734201
2EZH2_22144423_ChIP-Seq_EOC_Human6.65640949
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.10359282
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.04180091
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.97777785
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.30301912
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.27055460
8* DROSHA_22980978_ChIP-Seq_HELA_Human3.22259333
9* REST_21632747_ChIP-Seq_MESCs_Mouse3.17582373
10GBX2_23144817_ChIP-Seq_PC3_Human2.96034067
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.80971283
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.80971283
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.80971283
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.79532390
15SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.76170008
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.76120048
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.74435323
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71294111
19* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.69011780
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.55503005
21* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.53756741
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.52634241
23* REST_18959480_ChIP-ChIP_MESCs_Mouse2.46254317
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.39509322
25JARID2_20075857_ChIP-Seq_MESCs_Mouse2.38206469
26POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.38059509
27NANOG_18555785_ChIP-Seq_MESCs_Mouse2.34333387
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.33604477
29* EZH2_27304074_Chip-Seq_ESCs_Mouse2.33134528
30* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.28770514
31MYC_18358816_ChIP-ChIP_MESCs_Mouse2.27822439
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.23147729
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.23125144
34EZH2_27294783_Chip-Seq_ESCs_Mouse2.23020838
35NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.19955491
36RARB_27405468_Chip-Seq_BRAIN_Mouse2.18652135
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17142560
38SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16627789
39RNF2_27304074_Chip-Seq_ESCs_Mouse2.16294432
40RNF2_18974828_ChIP-Seq_MESCs_Mouse2.15725753
41EZH2_18974828_ChIP-Seq_MESCs_Mouse2.15725753
42SOX2_18555785_ChIP-Seq_MESCs_Mouse2.15087054
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14780523
44MTF2_20144788_ChIP-Seq_MESCs_Mouse2.12596071
45ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.07927576
46EST1_17652178_ChIP-ChIP_JURKAT_Human2.06555594
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.04582720
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.03848078
49TCF3_18692474_ChIP-Seq_MESCs_Mouse2.03842890
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.03258218
51NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02393261
52XRN2_22483619_ChIP-Seq_HELA_Human1.99705304
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.99406832
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.97818213
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97476097
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96991857
57* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.95146669
58* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.94930886
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.94605869
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94319489
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.93044206
62TCF3_18692474_ChIP-Seq_MEFs_Mouse1.91424959
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.91097503
64NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.88903231
65SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.88593888
66AR_21572438_ChIP-Seq_LNCaP_Human1.86435648
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.86262541
68* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85508726
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84010136
70* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83761847
71SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.83351510
72ETS1_20019798_ChIP-Seq_JURKAT_Human1.82623632
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.80744260
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.79553972
75SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.79055111
76MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78417329
77E2F1_21310950_ChIP-Seq_MCF-7_Human1.77833930
78NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.76693646
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76625796
80IKZF1_21737484_ChIP-ChIP_HCT116_Human1.74058361
81THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69541637
82ESR1_15608294_ChIP-ChIP_MCF-7_Human1.65700454
83ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.65453100
84* CBX2_27304074_Chip-Seq_ESCs_Mouse1.63202580
85JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.61873133
86AR_21909140_ChIP-Seq_LNCAP_Human1.60801257
87E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59084161
88* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57690399
89RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.52173758
90TTF2_22483619_ChIP-Seq_HELA_Human1.51670931
91RNF2_27304074_Chip-Seq_NSC_Mouse1.49067586
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48991966
93GABP_17652178_ChIP-ChIP_JURKAT_Human1.45041984
94POU5F1_16518401_ChIP-PET_MESCs_Mouse1.44607605
95SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.44514799
96TAF15_26573619_Chip-Seq_HEK293_Human1.41915726
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40609219
98CREB1_15753290_ChIP-ChIP_HEK293T_Human1.39331060
99ZNF274_21170338_ChIP-Seq_K562_Hela1.39285086
100SMAD4_21799915_ChIP-Seq_A2780_Human1.39020653
101KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.38347290
102VDR_23849224_ChIP-Seq_CD4+_Human1.38045100
103SOX2_16153702_ChIP-ChIP_HESCs_Human1.33312413
104NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.31587860
105FOXP3_21729870_ChIP-Seq_TREG_Human1.30206487
106* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28936808
107STAT3_23295773_ChIP-Seq_U87_Human1.28783391
108TP63_19390658_ChIP-ChIP_HaCaT_Human1.28242797
109SOX2_18692474_ChIP-Seq_MESCs_Mouse1.27150799
110POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.26975291
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26796138
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26796138
113HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26289951
114STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25391394
115RING1B_27294783_Chip-Seq_ESCs_Mouse1.24249786
116P300_19829295_ChIP-Seq_ESCs_Human1.23672367
117* AR_19668381_ChIP-Seq_PC3_Human1.23316746
118* FUS_26573619_Chip-Seq_HEK293_Human1.22763576
119NANOG_21062744_ChIP-ChIP_HESCs_Human1.22752626
120* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22243959
121POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19341188
122* TCF4_23295773_ChIP-Seq_U87_Human1.16965893
123YY1_21170310_ChIP-Seq_MESCs_Mouse1.16467392
124HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16291934
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15717639
126SOX2_21211035_ChIP-Seq_LN229_Gbm1.15239698
127TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.14286786
128ELK1_19687146_ChIP-ChIP_HELA_Human1.14239586
129EGR1_19374776_ChIP-ChIP_THP-1_Human1.14106691
130TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13232484
131NANOG_16153702_ChIP-ChIP_HESCs_Human1.12090521
132RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11127631
133GATA1_26923725_Chip-Seq_HPCs_Mouse1.10662854
134MYC_18940864_ChIP-ChIP_HL60_Human1.10477320
135CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09745127
136RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09735666
137AR_25329375_ChIP-Seq_VCAP_Human1.09398015
138MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09363130
139SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08907074
140SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08892916
141* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08784862
142KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08716158
143BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07433335
144IGF1R_20145208_ChIP-Seq_DFB_Human1.07301440
145PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07072145
146* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06400567
147NANOG_18692474_ChIP-Seq_MESCs_Mouse1.05975869
148SMAD3_21741376_ChIP-Seq_EPCs_Human1.05689881
149KDM5A_27292631_Chip-Seq_BREAST_Human1.05196221
150DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05158058
151DCP1A_22483619_ChIP-Seq_HELA_Human1.04531017
152POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.04241165
153NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02374855
154ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01968890
155PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01894793
156PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01761090
157OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00710706
158IRF1_19129219_ChIP-ChIP_H3396_Human1.00285349
159* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99861480
160GABP_19822575_ChIP-Seq_HepG2_Human0.99680126
161ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99384149
162CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98879754
163PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97922250
164NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96811922
165PRDM14_20953172_ChIP-Seq_ESCs_Human0.95321795
166VDR_22108803_ChIP-Seq_LS180_Human0.95145538
167PIAS1_25552417_ChIP-Seq_VCAP_Human0.95061836
168TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95010687
169RING1B_27294783_Chip-Seq_NPCs_Mouse0.94846218
170ERG_21242973_ChIP-ChIP_JURKAT_Human0.94494974
171CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94271429
172CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94145334
173NANOG_18692474_ChIP-Seq_MEFs_Mouse0.93537996
174* RUNX2_22187159_ChIP-Seq_PCA_Human0.93507565
175OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93430324
176KDM2B_26808549_Chip-Seq_REH_Human0.92945002
177* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92093378
178OCT4_18692474_ChIP-Seq_MEFs_Mouse0.91941045
179CIITA_25753668_ChIP-Seq_RAJI_Human0.91828393
180MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91525318
181* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91126120
182UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91072359
183POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90714551
184CTCF_27219007_Chip-Seq_Bcells_Human0.90560761
185KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90048110
186SMAD3_21741376_ChIP-Seq_ESCs_Human0.89942777
187SMAD4_21741376_ChIP-Seq_HESCs_Human0.89437588
188NANOG_16518401_ChIP-PET_MESCs_Mouse0.88443125
189NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87705650
190TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86039349
191STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.85634214
192P53_22127205_ChIP-Seq_FIBROBLAST_Human0.85489115
193CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85158452
194OCT4_19829295_ChIP-Seq_ESCs_Human0.85113734
195ER_23166858_ChIP-Seq_MCF-7_Human0.84321562
196BCAT_22108803_ChIP-Seq_LS180_Human0.84193453

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.21466186
2MP0003880_abnormal_central_pattern4.68880666
3MP0003941_abnormal_skin_development4.24219060
4MP0010094_abnormal_chromosome_stability3.78388004
5MP0003111_abnormal_nucleus_morphology3.74819595
6MP0004270_analgesia3.65420396
7MP0003635_abnormal_synaptic_transmissio3.63447247
8MP0003693_abnormal_embryo_hatching3.55573793
9MP0008057_abnormal_DNA_replication3.51472160
10MP0004957_abnormal_blastocyst_morpholog3.44955013
11MP0002064_seizures3.36662394
12MP0001968_abnormal_touch/_nociception3.34051531
13MP0009745_abnormal_behavioral_response3.26238724
14MP0002272_abnormal_nervous_system2.95402143
15MP0003077_abnormal_cell_cycle2.94560982
16MP0008058_abnormal_DNA_repair2.93075569
17MP0002063_abnormal_learning/memory/cond2.91920593
18MP0003123_paternal_imprinting2.88312205
19MP0004133_heterotaxia2.72645423
20MP0002734_abnormal_mechanical_nocicepti2.68024471
21MP0002572_abnormal_emotion/affect_behav2.55786802
22MP0003786_premature_aging2.51363954
23MP0001293_anophthalmia2.46878127
24MP0002735_abnormal_chemical_nociception2.41807660
25MP0003890_abnormal_embryonic-extraembry2.39444244
26MP0008932_abnormal_embryonic_tissue2.37582266
27MP0002736_abnormal_nociception_after2.34500630
28MP0008877_abnormal_DNA_methylation2.33683591
29MP0006292_abnormal_olfactory_placode2.31766545
30MP0003121_genomic_imprinting2.30828454
31MP0001501_abnormal_sleep_pattern2.30189577
32MP0002653_abnormal_ependyma_morphology2.19814710
33MP0003119_abnormal_digestive_system2.17007113
34MP0001970_abnormal_pain_threshold1.99576076
35MP0006276_abnormal_autonomic_nervous1.98797524
36MP0002733_abnormal_thermal_nociception1.95483414
37MP0003787_abnormal_imprinting1.92152512
38MP0000350_abnormal_cell_proliferation1.90172885
39MP0008569_lethality_at_weaning1.89089411
40MP0002067_abnormal_sensory_capabilities1.87526510
41MP0003718_maternal_effect1.86218416
42MP0004885_abnormal_endolymph1.85391227
43MP0008007_abnormal_cellular_replicative1.85202710
44MP0001730_embryonic_growth_arrest1.84011790
45MP0003136_yellow_coat_color1.83515067
46MP0003879_abnormal_hair_cell1.80907441
47MP0002084_abnormal_developmental_patter1.76230478
48MP0000569_abnormal_digit_pigmentation1.73039359
49MP0002085_abnormal_embryonic_tissue1.72508327
50MP0002557_abnormal_social/conspecific_i1.72093964
51MP0001986_abnormal_taste_sensitivity1.71682549
52MP0001672_abnormal_embryogenesis/_devel1.68824247
53MP0005380_embryogenesis_phenotype1.68824247
54MP0010307_abnormal_tumor_latency1.63585330
55MP0002822_catalepsy1.62125782
56MP0004197_abnormal_fetal_growth/weight/1.62015530
57MP0005646_abnormal_pituitary_gland1.60543460
58MP0003329_amyloid_beta_deposits1.59869389
59MP0001188_hyperpigmentation1.59849387
60MP0000537_abnormal_urethra_morphology1.58409885
61MP0001502_abnormal_circadian_rhythm1.57578895
62MP0003633_abnormal_nervous_system1.56517755
63MP0005645_abnormal_hypothalamus_physiol1.55750123
64MP0005551_abnormal_eye_electrophysiolog1.55471397
65MP0005386_behavior/neurological_phenoty1.54428009
66MP0004924_abnormal_behavior1.54428009
67MP0009672_abnormal_birth_weight1.53183023
68MP0004142_abnormal_muscle_tone1.51251079
69MP0004742_abnormal_vestibular_system1.50193907
70MP0004811_abnormal_neuron_physiology1.49988566
71MP0001697_abnormal_embryo_size1.49384498
72MP0003283_abnormal_digestive_organ1.47998790
73MP0000955_abnormal_spinal_cord1.47905829
74MP0001485_abnormal_pinna_reflex1.47724254
75MP0001905_abnormal_dopamine_level1.46465830
76MP0002882_abnormal_neuron_morphology1.45104830
77MP0001984_abnormal_olfaction1.42538547
78MP0010352_gastrointestinal_tract_polyps1.41321160
79MP0002697_abnormal_eye_size1.40164216
80MP0001440_abnormal_grooming_behavior1.39799482
81MP0003690_abnormal_glial_cell1.39723494
82MP0000920_abnormal_myelination1.39123614
83MP0003984_embryonic_growth_retardation1.39082592
84MP0002066_abnormal_motor_capabilities/c1.37917935
85MP0003631_nervous_system_phenotype1.37657761
86MP0002088_abnormal_embryonic_growth/wei1.37180991
87MP0009703_decreased_birth_body1.35922691
88MP0010030_abnormal_orbit_morphology1.35121611
89MP0001529_abnormal_vocalization1.33031631
90MP0003861_abnormal_nervous_system1.31936155
91MP0002184_abnormal_innervation1.31040357
92MP0001286_abnormal_eye_development1.28951116
93MP0002229_neurodegeneration1.27923892
94MP0002080_prenatal_lethality1.27536923
95MP0008872_abnormal_physiological_respon1.27485767
96MP0002086_abnormal_extraembryonic_tissu1.27255138
97MP0003937_abnormal_limbs/digits/tail_de1.25266924
98MP0005167_abnormal_blood-brain_barrier1.23747351
99MP0000516_abnormal_urinary_system1.22709996
100MP0005367_renal/urinary_system_phenotyp1.22709996
101MP0005394_taste/olfaction_phenotype1.22297987
102MP0005499_abnormal_olfactory_system1.22297987
103MP0005076_abnormal_cell_differentiation1.20131642
104MP0002111_abnormal_tail_morphology1.19890221
105MP0004147_increased_porphyrin_level1.19474427
106MP0001963_abnormal_hearing_physiology1.16529480
107MP0009780_abnormal_chondrocyte_physiolo1.11878312
108MP0002160_abnormal_reproductive_system1.11283783
109MP0002210_abnormal_sex_determination1.10009354
110MP0001145_abnormal_male_reproductive1.08423023
111MP0003122_maternal_imprinting1.08186795
112MP0008789_abnormal_olfactory_epithelium1.07834252
113MP0009053_abnormal_anal_canal1.04793933
114MP0000566_synostosis1.02960586
115MP0002638_abnormal_pupillary_reflex1.00975826
116MP0002233_abnormal_nose_morphology1.00860206
117MP0000049_abnormal_middle_ear1.00043462
118MP0000432_abnormal_head_morphology0.98421837
119MP0002092_abnormal_eye_morphology0.96674152
120MP0000653_abnormal_sex_gland0.94879870
121MP0001486_abnormal_startle_reflex0.91330867
122MP0004145_abnormal_muscle_electrophysio0.90869666
123MP0002752_abnormal_somatic_nervous0.89613687
124MP0001929_abnormal_gametogenesis0.89237835
125MP0001177_atelectasis0.89175652
126MP0000313_abnormal_cell_death0.88398914
127MP0002751_abnormal_autonomic_nervous0.86943175
128MP0003567_abnormal_fetal_cardiomyocyte0.86572408
129MP0003806_abnormal_nucleotide_metabolis0.85365920
130MP0004130_abnormal_muscle_cell0.84977310
131MP0002249_abnormal_larynx_morphology0.84115255
132MP0002938_white_spotting0.84090800
133MP0002152_abnormal_brain_morphology0.83989683
134MP0003632_abnormal_nervous_system0.83867339
135MP0003755_abnormal_palate_morphology0.82995382
136MP0003935_abnormal_craniofacial_develop0.81391268
137MP0003315_abnormal_perineum_morphology0.80896303
138MP0003634_abnormal_glial_cell0.79226514
139MP0008874_decreased_physiological_sensi0.78773187
140MP0002069_abnormal_eating/drinking_beha0.78171287
141MP0005253_abnormal_eye_physiology0.77714285
142MP0006072_abnormal_retinal_apoptosis0.76917313
143MP0002234_abnormal_pharynx_morphology0.75932150
144MP0010234_abnormal_vibrissa_follicle0.75703809
145MP0002909_abnormal_adrenal_gland0.74656168
146MP0008770_decreased_survivor_rate0.73849305
147MP0000678_abnormal_parathyroid_gland0.73702337
148MP0002081_perinatal_lethality0.73570226
149MP0003698_abnormal_male_reproductive0.72453814
150MP0003938_abnormal_ear_development0.71058078
151MP0005423_abnormal_somatic_nervous0.70220732
152MP0003115_abnormal_respiratory_system0.69996171
153MP0000631_abnormal_neuroendocrine_gland0.69192667
154MP0000490_abnormal_crypts_of0.69122945
155MP0000026_abnormal_inner_ear0.68817914
156MP0005391_vision/eye_phenotype0.67873935
157MP0001348_abnormal_lacrimal_gland0.66918548
158MP0005535_abnormal_body_temperature0.66425895
159MP0000778_abnormal_nervous_system0.66250940
160MP0005389_reproductive_system_phenotype0.66192949
161MP0003878_abnormal_ear_physiology0.65281682
162MP0005377_hearing/vestibular/ear_phenot0.65281682
163MP0002177_abnormal_outer_ear0.63645217
164MP0001346_abnormal_lacrimal_gland0.63192934
165MP0003936_abnormal_reproductive_system0.62959965
166MP0002114_abnormal_axial_skeleton0.62487529
167MP0009046_muscle_twitch0.62422526
168MP0005171_absent_coat_pigmentation0.62015694
169MP0000427_abnormal_hair_cycle0.61030564
170MP0000604_amyloidosis0.60547057
171MP0002876_abnormal_thyroid_physiology0.59290211
172MP0010386_abnormal_urinary_bladder0.58532654
173MP0004043_abnormal_pH_regulation0.58349463
174MP0003045_fibrosis0.57304145
175MP0005174_abnormal_tail_pigmentation0.56845803
176MP0010769_abnormal_survival0.56049824
177MP0010770_preweaning_lethality0.55588154
178MP0002082_postnatal_lethality0.55588154
179MP0003183_abnormal_peptide_metabolism0.54048802
180MP0010768_mortality/aging0.53484285

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.73639683
2Myokymia (HP:0002411)6.34057964
3Focal seizures (HP:0007359)5.62955919
4Febrile seizures (HP:0002373)5.31357055
5Epileptic encephalopathy (HP:0200134)5.02303093
6Abnormality of the labia minora (HP:0012880)4.85413084
7Progressive cerebellar ataxia (HP:0002073)4.78527429
8Diplopia (HP:0000651)4.58983697
9Abnormality of binocular vision (HP:0011514)4.58983697
10Chromosomal breakage induced by crosslinking agents (HP:0003221)4.55578888
11Chromsome breakage (HP:0040012)4.47411503
12Atonic seizures (HP:0010819)4.26959995
13Action tremor (HP:0002345)4.18247090
14Ependymoma (HP:0002888)3.99972308
15Limb dystonia (HP:0002451)3.85444552
16Hemiparesis (HP:0001269)3.73496096
17Generalized tonic-clonic seizures (HP:0002069)3.71628244
18Ankle clonus (HP:0011448)3.70121725
19Hyperventilation (HP:0002883)3.66896410
20Genetic anticipation (HP:0003743)3.64248924
21Spastic gait (HP:0002064)3.57608164
22Gaze-evoked nystagmus (HP:0000640)3.45827799
23Medulloblastoma (HP:0002885)3.44300523
24Supranuclear gaze palsy (HP:0000605)3.43545894
25Visual hallucinations (HP:0002367)3.39739854
26Supernumerary spleens (HP:0009799)3.38194001
27Absent radius (HP:0003974)3.32749561
28Aplasia/Hypoplasia of the sternum (HP:0006714)3.28497222
29Colon cancer (HP:0003003)3.24007286
30Dialeptic seizures (HP:0011146)3.22237378
31Abnormal eating behavior (HP:0100738)3.20622007
32Aplasia involving forearm bones (HP:0009822)3.19574930
33Absent forearm bone (HP:0003953)3.19574930
34Abnormality of the astrocytes (HP:0100707)3.17082674
35Astrocytoma (HP:0009592)3.17082674
36Birth length less than 3rd percentile (HP:0003561)3.16583123
37Broad-based gait (HP:0002136)3.16221708
38Urinary bladder sphincter dysfunction (HP:0002839)3.15781964
39Hemiplegia (HP:0002301)3.11249099
40High anterior hairline (HP:0009890)3.06685236
41Truncal ataxia (HP:0002078)3.05956561
42Abnormality of abdominal situs (HP:0011620)3.03650270
43Abdominal situs inversus (HP:0003363)3.03650270
44Postural instability (HP:0002172)3.03482520
45Absence seizures (HP:0002121)3.02056983
46Aplasia/Hypoplasia of the uvula (HP:0010293)3.00928947
47Absent thumb (HP:0009777)2.91297161
48Reticulocytopenia (HP:0001896)2.88809461
49Status epilepticus (HP:0002133)2.88568665
50Abnormality of chromosome stability (HP:0003220)2.80598184
51Meckel diverticulum (HP:0002245)2.79030837
52Abnormality of the preputium (HP:0100587)2.77548191
53Papilledema (HP:0001085)2.76497306
54Epileptiform EEG discharges (HP:0011182)2.75859632
55Neoplasm of the oral cavity (HP:0100649)2.75323414
56Duplicated collecting system (HP:0000081)2.75118368
57Impulsivity (HP:0100710)2.74285877
58Poor eye contact (HP:0000817)2.73313179
59Mutism (HP:0002300)2.72597269
60Agnosia (HP:0010524)2.72276366
61Polyphagia (HP:0002591)2.70078082
62Abnormal lung lobation (HP:0002101)2.70034877
63Anophthalmia (HP:0000528)2.69677672
64Abnormality of the ileum (HP:0001549)2.68753465
65Abnormality of the corticospinal tract (HP:0002492)2.68186623
66Breast hypoplasia (HP:0003187)2.67824784
67Esophageal atresia (HP:0002032)2.66671057
68Glioma (HP:0009733)2.66567753
69Akinesia (HP:0002304)2.64100321
70Rhabdomyosarcoma (HP:0002859)2.64083642
71Absent eyebrow (HP:0002223)2.63033386
72Neurofibrillary tangles (HP:0002185)2.55971011
73Dysmetria (HP:0001310)2.54255373
74Impaired smooth pursuit (HP:0007772)2.54080032
75Rib fusion (HP:0000902)2.53166579
76Skull defect (HP:0001362)2.52376096
77Selective tooth agenesis (HP:0001592)2.50162725
78Impaired vibration sensation in the lower limbs (HP:0002166)2.49417430
79EEG with generalized epileptiform discharges (HP:0011198)2.49199311
80Patellar aplasia (HP:0006443)2.48386107
81Amblyopia (HP:0000646)2.45367878
82Hypsarrhythmia (HP:0002521)2.43763002
83Urinary urgency (HP:0000012)2.42862346
84Drooling (HP:0002307)2.42728734
85Supernumerary bones of the axial skeleton (HP:0009144)2.42427111
86Bilateral microphthalmos (HP:0007633)2.40805727
87Absent speech (HP:0001344)2.39773416
88Dysdiadochokinesis (HP:0002075)2.37959074
89Torticollis (HP:0000473)2.37705546
90Clonus (HP:0002169)2.36806711
91Abnormality of the renal collecting system (HP:0004742)2.35711250
92Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.35519399
93Degeneration of the lateral corticospinal tracts (HP:0002314)2.35519399
94Bifid tongue (HP:0010297)2.33351072
95Gait imbalance (HP:0002141)2.33331300
96Morphological abnormality of the pyramidal tract (HP:0002062)2.32645364
97Shawl scrotum (HP:0000049)2.32500070
98Supernumerary ribs (HP:0005815)2.31819162
99Aplasia/hypoplasia of the humerus (HP:0006507)2.31150622
100Gastrointestinal atresia (HP:0002589)2.30362266
101Missing ribs (HP:0000921)2.28957720
102Intention tremor (HP:0002080)2.27039553
103Rectovaginal fistula (HP:0000143)2.26927464
104Rectal fistula (HP:0100590)2.26927464
105Lower limb muscle weakness (HP:0007340)2.26785643
106Aplasia/Hypoplasia of the patella (HP:0006498)2.26154830
107Spastic tetraparesis (HP:0001285)2.26097659
108Obstructive sleep apnea (HP:0002870)2.25759022
109Inability to walk (HP:0002540)2.25495726
110Excessive salivation (HP:0003781)2.24392595
111Protruding tongue (HP:0010808)2.23474324
112Cerebral hypomyelination (HP:0006808)2.22926655
113Abnormal social behavior (HP:0012433)2.22085942
114Impaired social interactions (HP:0000735)2.22085942
115Neoplasm of striated muscle (HP:0009728)2.22019249
116Ectopic kidney (HP:0000086)2.21960749
117Nephroblastoma (Wilms tumor) (HP:0002667)2.20734105
118Congenital stationary night blindness (HP:0007642)2.20263729
119Facial cleft (HP:0002006)2.19761680
120Anxiety (HP:0000739)2.19387133
121Abnormal number of incisors (HP:0011064)2.18870902
122Intestinal atresia (HP:0011100)2.18762992
123Abnormality of ocular smooth pursuit (HP:0000617)2.18583157
124Breast aplasia (HP:0100783)2.18430186
125Bradykinesia (HP:0002067)2.18147693
126Septo-optic dysplasia (HP:0100842)2.16785899
127Sleep apnea (HP:0010535)2.16466105
128Horseshoe kidney (HP:0000085)2.16205375
129Peripheral hypomyelination (HP:0007182)2.15980237
130Depression (HP:0000716)2.14412678
131Oral leukoplakia (HP:0002745)2.13317411
132Short humerus (HP:0005792)2.13226778
133Small intestinal stenosis (HP:0012848)2.12228572
134Duodenal stenosis (HP:0100867)2.12228572
135Anal stenosis (HP:0002025)2.12198673
136Amyotrophic lateral sclerosis (HP:0007354)2.10824828
137Intestinal fistula (HP:0100819)2.09313242
138Stereotypic behavior (HP:0000733)2.08846439
139Bicornuate uterus (HP:0000813)2.07362950
140Short thumb (HP:0009778)2.06698949
141Absent eyelashes (HP:0000561)2.06569899
142Embryonal renal neoplasm (HP:0011794)2.06276261
143Triphalangeal thumb (HP:0001199)2.05981322
144Cleft eyelid (HP:0000625)2.04386086
145Fetal akinesia sequence (HP:0001989)2.03202157
146Cellular immunodeficiency (HP:0005374)2.02134696
147Abnormality of the duodenum (HP:0002246)2.01308583
148Biliary tract neoplasm (HP:0100574)2.01120725
149Tracheoesophageal fistula (HP:0002575)1.99012333
150Increased circulating renin level (HP:0000848)1.98869482
151Abnormality of the clitoris (HP:0000056)1.97920664
152Aplasia/Hypoplasia of the breasts (HP:0010311)1.97138603
153Anal atresia (HP:0002023)1.95707432
154Scanning speech (HP:0002168)1.95464107
155Clumsiness (HP:0002312)1.94904095
156Impaired vibratory sensation (HP:0002495)1.94854939
157Annular pancreas (HP:0001734)1.93472817
158Sloping forehead (HP:0000340)1.93036767
159Focal dystonia (HP:0004373)1.92451003
160Abnormality of the carotid arteries (HP:0005344)1.90509559
161Volvulus (HP:0002580)1.89499638
162Cerebral inclusion bodies (HP:0100314)1.89487713
163Delusions (HP:0000746)1.89335843
164Carpal bone hypoplasia (HP:0001498)1.88314143
165Neuronal loss in central nervous system (HP:0002529)1.88254167
166Atresia of the external auditory canal (HP:0000413)1.84945559
167Ulnar claw (HP:0001178)1.84368268
168Polydipsia (HP:0001959)1.84282961
169Abnormal drinking behavior (HP:0030082)1.84282961
170Medial flaring of the eyebrow (HP:0010747)1.83170970
171Prolonged QT interval (HP:0001657)1.82833913
172Tetraplegia (HP:0002445)1.82401334
173Asplenia (HP:0001746)1.82122718
174Myelomeningocele (HP:0002475)1.81883943
175Agitation (HP:0000713)1.81808252
176Abnormality of pyrimidine metabolism (HP:0004353)1.81137514
177Myelodysplasia (HP:0002863)1.81006100
178Duplication of thumb phalanx (HP:0009942)1.79846071
179Split foot (HP:0001839)1.79704527
180Oligodactyly (hands) (HP:0001180)1.79139135
181Specific learning disability (HP:0001328)1.79046422
182Progressive inability to walk (HP:0002505)1.78258875
183Morphological abnormality of the middle ear (HP:0008609)1.77710247
184Spastic tetraplegia (HP:0002510)1.77202147
185Neoplasm of the pancreas (HP:0002894)1.77195630
186Oligodactyly (HP:0012165)1.77190893
187Intellectual disability, severe (HP:0010864)1.77108208
188Midline defect of the nose (HP:0004122)1.76868784
189Abnormality of the lower motor neuron (HP:0002366)1.76400059
190Decreased central vision (HP:0007663)1.75903957
191Cafe-au-lait spot (HP:0000957)1.75523930
192Stenosis of the external auditory canal (HP:0000402)1.74269178
193Megalencephaly (HP:0001355)1.74185860
194Spastic diplegia (HP:0001264)1.74139709
195Facial hemangioma (HP:0000329)1.74120513
196Gastroesophageal reflux (HP:0002020)1.70343510
197Proximal placement of thumb (HP:0009623)1.68921496
198Craniofacial dystonia (HP:0012179)1.68654277
199Choreoathetosis (HP:0001266)1.67385868

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.65374846
2EPHA43.91139518
3CDK123.34807049
4SRPK13.28534047
5DAPK23.13747322
6EPHA22.99026780
7WEE12.92649199
8INSRR2.81618206
9TLK12.80691607
10TTK2.60484276
11PAK62.58272993
12MAPK132.54006818
13MKNK22.52689699
14NEK12.45735071
15PNCK2.42279756
16NEK22.41312519
17MKNK12.37301348
18TSSK62.31070907
19BUB12.25123449
20BRD42.24237360
21AKT32.20736433
22CAMKK12.14257040
23PLK32.09480727
24PLK11.96059492
25SIK21.92111607
26MINK11.82865119
27ERBB41.82822023
28CDK71.77818893
29ATR1.70082875
30PLK41.68570156
31CHEK21.68055575
32PINK11.66654050
33RPS6KB21.62259795
34VRK11.61915510
35EIF2AK11.56525768
36CHEK11.54971338
37ZAK1.51770762
38LATS21.48860171
39CAMK11.46145130
40PRKCG1.45251103
41PRKD31.43822915
42AURKB1.42395322
43CDK51.40361326
44SGK2231.38014532
45SGK4941.38014532
46AURKA1.36306045
47ATM1.34247588
48PASK1.31144341
49ALK1.30801679
50PHKG21.27360261
51PHKG11.27360261
52PKN11.27181511
53TNK21.25206420
54CAMKK21.25196493
55NTRK31.24057875
56OXSR11.21204048
57GRK51.18731045
58RIPK41.18312534
59PAK31.18210649
60STK111.13064854
61TYRO31.11901597
62CDK21.11119895
63SCYL21.10045639
64CAMK2B1.09482178
65CASK1.08717583
66SGK21.05848185
67CDK41.04280047
68CDK191.03754403
69CAMK41.01402152
70CAMK2A1.00866828
71PRKCH0.99417410
72NTRK10.98952430
73STK38L0.98796635
74MARK20.97894796
75MAPK120.96719434
76PIM20.96028850
77MAPKAPK50.95991518
78MAP2K70.94428412
79DYRK30.93372173
80WNK40.93215822
81MAP4K20.92167360
82YES10.92091848
83MAP3K40.92086480
84CDK10.90498541
85EIF2AK20.90323109
86LATS10.87534728
87RAF10.86889034
88EIF2AK30.86722502
89SGK10.85758233
90CSNK1E0.85710260
91MAP3K70.85506276
92CAMK1G0.84618755
93MAP3K80.83588592
94CSNK1D0.82928055
95ACVR1B0.81704667
96WNK30.81657077
97ADRBK20.80857605
98PLK20.79946548
99STK160.78273519
100CSNK2A20.76499061
101NME10.74449623
102ICK0.73616779
103BRAF0.73607396
104PRKCZ0.73523932
105MAP3K90.73347469
106PRKDC0.68873946
107PRKCI0.68773487
108TAOK30.68078339
109AKT20.62965825
110MAP2K40.62690110
111STK40.62350261
112MTOR0.61507198
113CAMK2G0.61082821
114TNIK0.61064172
115BRSK20.60785608
116CSNK1G20.60749573
117WNK10.59031404
118EEF2K0.58765505
119DYRK20.57963317
120STK390.56425475
121RPS6KA30.56247799
122FES0.56067036
123MAPK140.55114162
124CDK150.54091167
125BMPR1B0.53997772
126GSK3B0.53249774
127PTK2B0.52882849
128CCNB10.52228348
129CSNK2A10.52189598
130CDK180.52098578
131MAPK150.50703623
132BCR0.49385087
133CDK80.49259781
134PRKCE0.49129650
135GRK10.49031168
136SGK30.48942601
137MAP2K60.47358998
138PDK20.47049026
139PDK10.46816712
140PRPF4B0.46721757
141PIM10.46683217
142CDK11A0.46580169
143FGFR10.46371517
144CDK140.45360347
145NTRK20.43881240
146PRKG10.43122086
147MARK10.42386301
148MAPK100.42063249
149CAMK1D0.41589159
150FLT30.40571343
151PRKACA0.39667169
152AKT10.39304470
153CAMK2D0.39274606
154PRKAA10.38310221
155FGFR20.38253321
156PRKCA0.38193812
157RPS6KB10.37235008
158ADRBK10.36787569
159UHMK10.36504161
160MAPK80.36443622
161PAK40.35306033
162BRSK10.34942287
163DYRK1A0.34522126
164PRKCQ0.34192629
165STK380.34131599
166KSR10.33573921
167RPS6KA50.32916094
168FRK0.32599308
169MAPK10.32420495
170DAPK10.31647641
171PDK30.29879441
172PDK40.29879441
173TESK20.24731639
174PAK10.24149304
175MELK0.22912651
176NEK60.21278606
177CSNK1G30.20725827
178CSNK1G10.20269013

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.53678161
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.22776648
3DNA replication_Homo sapiens_hsa030304.21429218
4One carbon pool by folate_Homo sapiens_hsa006703.64836013
5Spliceosome_Homo sapiens_hsa030403.42860690
6RNA transport_Homo sapiens_hsa030133.33810429
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.32941047
8Homologous recombination_Homo sapiens_hsa034403.07490148
9Fanconi anemia pathway_Homo sapiens_hsa034603.03717288
10Circadian entrainment_Homo sapiens_hsa047132.98700582
11RNA polymerase_Homo sapiens_hsa030202.86393321
12Nucleotide excision repair_Homo sapiens_hsa034202.79273341
13Ribosome_Homo sapiens_hsa030102.50664357
14Base excision repair_Homo sapiens_hsa034102.46747684
15Insulin secretion_Homo sapiens_hsa049112.43257071
16Cell cycle_Homo sapiens_hsa041102.41215541
17mRNA surveillance pathway_Homo sapiens_hsa030152.35570841
18Non-homologous end-joining_Homo sapiens_hsa034502.27888369
19Cocaine addiction_Homo sapiens_hsa050302.23551163
20Cholinergic synapse_Homo sapiens_hsa047251.94492591
21Gastric acid secretion_Homo sapiens_hsa049711.94384034
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.94246747
23RNA degradation_Homo sapiens_hsa030181.91224170
24Pyrimidine metabolism_Homo sapiens_hsa002401.90150949
25Systemic lupus erythematosus_Homo sapiens_hsa053221.84804839
26Salivary secretion_Homo sapiens_hsa049701.80426158
27Basal transcription factors_Homo sapiens_hsa030221.79716703
28Calcium signaling pathway_Homo sapiens_hsa040201.63592947
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56362000
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.54780285
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51379073
32Oxytocin signaling pathway_Homo sapiens_hsa049211.50004608
33cAMP signaling pathway_Homo sapiens_hsa040241.48712972
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.47923329
35Olfactory transduction_Homo sapiens_hsa047401.45404506
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45018348
37Basal cell carcinoma_Homo sapiens_hsa052171.44053798
38Proteasome_Homo sapiens_hsa030501.37802714
39Renin secretion_Homo sapiens_hsa049241.33311841
40Oocyte meiosis_Homo sapiens_hsa041141.33096661
41Alcoholism_Homo sapiens_hsa050341.32473082
42p53 signaling pathway_Homo sapiens_hsa041151.31407069
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29371761
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.26747405
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21055916
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20809066
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17088608
48Nicotine addiction_Homo sapiens_hsa050331.16461582
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.15776825
50Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14053266
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.08826652
52Purine metabolism_Homo sapiens_hsa002301.08611954
53Hippo signaling pathway_Homo sapiens_hsa043901.05737555
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02410163
55Hedgehog signaling pathway_Homo sapiens_hsa043400.99904147
56Collecting duct acid secretion_Homo sapiens_hsa049660.97253272
57Nitrogen metabolism_Homo sapiens_hsa009100.96067482
58Pancreatic secretion_Homo sapiens_hsa049720.90850579
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88666791
60GnRH signaling pathway_Homo sapiens_hsa049120.87727887
61Bile secretion_Homo sapiens_hsa049760.87681798
62Histidine metabolism_Homo sapiens_hsa003400.86308609
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85546121
64MAPK signaling pathway_Homo sapiens_hsa040100.84849119
65MicroRNAs in cancer_Homo sapiens_hsa052060.84323579
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84047358
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84034875
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.82143525
69Type II diabetes mellitus_Homo sapiens_hsa049300.80891946
70Cardiac muscle contraction_Homo sapiens_hsa042600.80278697
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.77747614
72Wnt signaling pathway_Homo sapiens_hsa043100.77097559
73Selenocompound metabolism_Homo sapiens_hsa004500.76698067
74Circadian rhythm_Homo sapiens_hsa047100.76580432
75Lysine degradation_Homo sapiens_hsa003100.75927257
76Viral carcinogenesis_Homo sapiens_hsa052030.75338527
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.73965362
78ABC transporters_Homo sapiens_hsa020100.73722814
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72126436
80Biosynthesis of amino acids_Homo sapiens_hsa012300.72103175
81Type I diabetes mellitus_Homo sapiens_hsa049400.71630525
82Ras signaling pathway_Homo sapiens_hsa040140.71181505
83TGF-beta signaling pathway_Homo sapiens_hsa043500.70563483
84Thyroid hormone synthesis_Homo sapiens_hsa049180.69670889
85Epstein-Barr virus infection_Homo sapiens_hsa051690.67666561
86Vitamin B6 metabolism_Homo sapiens_hsa007500.67342121
87Dorso-ventral axis formation_Homo sapiens_hsa043200.66310025
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65968223
89beta-Alanine metabolism_Homo sapiens_hsa004100.65270705
90Ether lipid metabolism_Homo sapiens_hsa005650.64918525
91Ovarian steroidogenesis_Homo sapiens_hsa049130.61109520
92Huntingtons disease_Homo sapiens_hsa050160.60665242
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60314147
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56020695
95Tight junction_Homo sapiens_hsa045300.55493646
96Thyroid cancer_Homo sapiens_hsa052160.55001777
97Notch signaling pathway_Homo sapiens_hsa043300.54570988
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52567448
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52519576
100Butanoate metabolism_Homo sapiens_hsa006500.51669095
101Melanoma_Homo sapiens_hsa052180.50452105
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48574846
103Linoleic acid metabolism_Homo sapiens_hsa005910.48322518
104Melanogenesis_Homo sapiens_hsa049160.47952499
105Regulation of autophagy_Homo sapiens_hsa041400.47864320
106Long-term potentiation_Homo sapiens_hsa047200.47547882
107HTLV-I infection_Homo sapiens_hsa051660.45967798
108Synaptic vesicle cycle_Homo sapiens_hsa047210.45285698
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45161011
110Arginine biosynthesis_Homo sapiens_hsa002200.43540306
111Colorectal cancer_Homo sapiens_hsa052100.41311992
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.41298828
113mTOR signaling pathway_Homo sapiens_hsa041500.40921347
114Long-term depression_Homo sapiens_hsa047300.40791425
115Arginine and proline metabolism_Homo sapiens_hsa003300.40276104
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39952342
117Choline metabolism in cancer_Homo sapiens_hsa052310.39145662
118Pathways in cancer_Homo sapiens_hsa052000.37989266
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37815898
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.37543613
121Mineral absorption_Homo sapiens_hsa049780.36548280
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35700278
123Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35199764
124Glycerolipid metabolism_Homo sapiens_hsa005610.33253020
125Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.32457515
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.30698859
127Adherens junction_Homo sapiens_hsa045200.29996124
128Bladder cancer_Homo sapiens_hsa052190.29769796
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.28178790
130Endocytosis_Homo sapiens_hsa041440.27440303
131Herpes simplex infection_Homo sapiens_hsa051680.26678030
132VEGF signaling pathway_Homo sapiens_hsa043700.26160553
133Endometrial cancer_Homo sapiens_hsa052130.25604599
134GABAergic synapse_Homo sapiens_hsa047270.25485869
135Fatty acid biosynthesis_Homo sapiens_hsa000610.25231520
136Taste transduction_Homo sapiens_hsa047420.24895089
137Serotonergic synapse_Homo sapiens_hsa047260.24418335
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24117181
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23495251
140Prostate cancer_Homo sapiens_hsa052150.22379516
141Alzheimers disease_Homo sapiens_hsa050100.21728721
142Inositol phosphate metabolism_Homo sapiens_hsa005620.20212139
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20208584
144Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19692207
145ErbB signaling pathway_Homo sapiens_hsa040120.18802592
146HIF-1 signaling pathway_Homo sapiens_hsa040660.18696989
147Amphetamine addiction_Homo sapiens_hsa050310.16428336
148Phototransduction_Homo sapiens_hsa047440.16296689
149Dopaminergic synapse_Homo sapiens_hsa047280.16058564
150Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.14933720
151Rap1 signaling pathway_Homo sapiens_hsa040150.12942385
152Morphine addiction_Homo sapiens_hsa050320.11970772
153Carbon metabolism_Homo sapiens_hsa012000.10740097
1542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.10430795
155Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.09955287
156Oxidative phosphorylation_Homo sapiens_hsa001900.09824350
157Glutamatergic synapse_Homo sapiens_hsa047240.09617550
158Estrogen signaling pathway_Homo sapiens_hsa049150.08694867
159Glucagon signaling pathway_Homo sapiens_hsa049220.08507375
160Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.07656049
161Gap junction_Homo sapiens_hsa045400.06753498
162Axon guidance_Homo sapiens_hsa043600.06285484
163Fructose and mannose metabolism_Homo sapiens_hsa000510.06218553
164PI3K-Akt signaling pathway_Homo sapiens_hsa041510.05874835
165Small cell lung cancer_Homo sapiens_hsa052220.05812162
166FoxO signaling pathway_Homo sapiens_hsa040680.05728702
167Metabolic pathways_Homo sapiens_hsa011000.05335803
168Glioma_Homo sapiens_hsa052140.05295573

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