ADAT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the ADAR (adenosine deaminase acting on RNA) family. Using site-specific adenosine modification, proteins encoded by these genes participate in the pre-mRNA editing of nuclear transcripts. The protein encoded by this gene, tRNA-specific adenosine deaminase 1, is responsible for the deamination of adenosine 37 to inosine in eukaryotic tRNA. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1centriole replication (GO:0007099)4.47671032
2piRNA metabolic process (GO:0034587)4.45896920
3male meiosis (GO:0007140)4.43943202
4meiotic chromosome segregation (GO:0045132)4.38197437
5response to pheromone (GO:0019236)4.28185526
6regulation of helicase activity (GO:0051095)4.13613579
7regulation of nuclear cell cycle DNA replication (GO:0033262)4.10079293
8kinetochore assembly (GO:0051382)4.08285833
9DNA methylation involved in gamete generation (GO:0043046)4.07672867
10behavioral response to nicotine (GO:0035095)4.07097808
11kinetochore organization (GO:0051383)4.04740775
12synapsis (GO:0007129)3.99707294
13tRNA methylation (GO:0030488)3.92748556
14chromatin remodeling at centromere (GO:0031055)3.82212915
15CENP-A containing nucleosome assembly (GO:0034080)3.77356732
16somatic hypermutation of immunoglobulin genes (GO:0016446)3.74139402
17somatic diversification of immune receptors via somatic mutation (GO:0002566)3.74139402
18epithelial cilium movement (GO:0003351)3.72718400
19mismatch repair (GO:0006298)3.70677711
20regulation of meiosis I (GO:0060631)3.65838280
21metaphase plate congression (GO:0051310)3.64281950
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.62710505
23nuclear pore organization (GO:0006999)3.62170102
24deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.56166760
25microtubule depolymerization (GO:0007019)3.56108009
26reciprocal DNA recombination (GO:0035825)3.53131678
27reciprocal meiotic recombination (GO:0007131)3.53131678
28telomere maintenance via semi-conservative replication (GO:0032201)3.52509411
29mitotic metaphase plate congression (GO:0007080)3.51573170
30establishment of chromosome localization (GO:0051303)3.49735866
31DNA integration (GO:0015074)3.49733566
32DNA strand elongation involved in DNA replication (GO:0006271)3.49338215
33single strand break repair (GO:0000012)3.47402414
34positive regulation of DNA-dependent DNA replication (GO:2000105)3.45711416
35pyrimidine dimer repair (GO:0006290)3.42825045
36DNA strand elongation (GO:0022616)3.42700554
37DNA replication initiation (GO:0006270)3.39755093
38double-strand break repair via homologous recombination (GO:0000724)3.34583525
39DNA synthesis involved in DNA repair (GO:0000731)3.34492030
40pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.32414794
41male meiosis I (GO:0007141)3.30979082
42protein K11-linked deubiquitination (GO:0035871)3.30914863
43recombinational repair (GO:0000725)3.29819200
44hepatocyte apoptotic process (GO:0097284)3.29500579
45nuclear pore complex assembly (GO:0051292)3.26824603
46rRNA modification (GO:0000154)3.26616707
47intra-S DNA damage checkpoint (GO:0031573)3.26052738
48transcription-coupled nucleotide-excision repair (GO:0006283)3.24641830
49regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.24632901
50regulation of centriole replication (GO:0046599)3.24263887
51telomere maintenance via telomere lengthening (GO:0010833)3.21357705
52rRNA methylation (GO:0031167)3.21266641
53multicellular organism reproduction (GO:0032504)3.20432737
54regulation of posttranscriptional gene silencing (GO:0060147)3.19521382
55regulation of gene silencing by miRNA (GO:0060964)3.19521382
56regulation of gene silencing by RNA (GO:0060966)3.19521382
57meiosis I (GO:0007127)3.19252759
58transcription elongation from RNA polymerase I promoter (GO:0006362)3.14745687
59ribosomal small subunit assembly (GO:0000028)3.14506862
60telomere maintenance via recombination (GO:0000722)3.14260118
61meiotic nuclear division (GO:0007126)3.11832654
62cornea development in camera-type eye (GO:0061303)3.11663897
63termination of RNA polymerase I transcription (GO:0006363)3.11491019
64protein polyglutamylation (GO:0018095)3.09687857
65pseudouridine synthesis (GO:0001522)3.08607550
66DNA strand renaturation (GO:0000733)3.07065416
67DNA replication-independent nucleosome organization (GO:0034724)3.06925510
68DNA replication-independent nucleosome assembly (GO:0006336)3.06925510
69mitotic recombination (GO:0006312)3.05545264
70histone H3-K9 methylation (GO:0051567)3.05382628
71neural tube formation (GO:0001841)3.04474314
72pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.03289120
73poly(A)+ mRNA export from nucleus (GO:0016973)3.03126527
74modulation by virus of host process (GO:0019054)3.00121134
75ribosomal large subunit biogenesis (GO:0042273)2.99467754
76gene silencing by RNA (GO:0031047)2.98862497
77tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.98857348
78RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.98857348
79regulation of mitochondrial translation (GO:0070129)2.98768362
80pore complex assembly (GO:0046931)2.98613467
81DNA replication-dependent nucleosome assembly (GO:0006335)2.98028595
82DNA replication-dependent nucleosome organization (GO:0034723)2.98028595
83preassembly of GPI anchor in ER membrane (GO:0016254)2.97769065
84protein neddylation (GO:0045116)2.97189859
85regulation of double-strand break repair via homologous recombination (GO:0010569)2.97131132
86meiotic cell cycle (GO:0051321)2.96698639
87resolution of meiotic recombination intermediates (GO:0000712)2.96570557
88histone exchange (GO:0043486)2.95282284
89attachment of spindle microtubules to kinetochore (GO:0008608)2.94658363
90protein K6-linked ubiquitination (GO:0085020)2.94656405
91regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.91491363
92regulation of mitotic spindle checkpoint (GO:1903504)2.91491363
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.90581457
94DNA replication checkpoint (GO:0000076)2.90410959
95DNA double-strand break processing (GO:0000729)2.89707185
96maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.88870197
97negative regulation of DNA recombination (GO:0045910)2.88796976
98histone H2A acetylation (GO:0043968)2.87443366
997-methylguanosine mRNA capping (GO:0006370)2.87128587
100RNA capping (GO:0036260)2.87013729
1017-methylguanosine RNA capping (GO:0009452)2.87013729
102paraxial mesoderm development (GO:0048339)2.86876582
103chromosome organization involved in meiosis (GO:0070192)2.86491187
104double-strand break repair (GO:0006302)2.86449545
105negative regulation of DNA-dependent DNA replication (GO:2000104)2.85065637
106nucleotide-excision repair, DNA gap filling (GO:0006297)2.84483039
107negative regulation of telomere maintenance (GO:0032205)2.83613801
108histone H3-K9 modification (GO:0061647)2.79969694
109female gamete generation (GO:0007292)2.79690508
110transcription from RNA polymerase I promoter (GO:0006360)2.79459252
111nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.78575968
112DNA catabolic process, exonucleolytic (GO:0000738)2.78434872
113ribosome biogenesis (GO:0042254)2.77521950
114telomere maintenance via telomerase (GO:0007004)2.76699238
115microtubule polymerization or depolymerization (GO:0031109)2.76331787
116viral mRNA export from host cell nucleus (GO:0046784)2.75051625
117peptidyl-histidine modification (GO:0018202)2.74219358
118transcription elongation from RNA polymerase III promoter (GO:0006385)2.74075774
119termination of RNA polymerase III transcription (GO:0006386)2.74075774
120DNA deamination (GO:0045006)2.74039150
121centriole assembly (GO:0098534)2.74006731
122DNA methylation (GO:0006306)2.73916113
123DNA alkylation (GO:0006305)2.73916113
124cilium movement (GO:0003341)2.72413921
125nucleotide-excision repair (GO:0006289)2.72411902
126pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.71281614
127mitotic sister chromatid segregation (GO:0000070)2.69743969
128cilium morphogenesis (GO:0060271)2.69600221
129replication fork processing (GO:0031297)2.69510883
130DNA ligation (GO:0006266)2.69408320
131pyrimidine nucleotide catabolic process (GO:0006244)2.68863450
132snRNA processing (GO:0016180)2.68846710
133tRNA modification (GO:0006400)2.68791060
134RNA methylation (GO:0001510)2.68473460
135negative regulation of translation, ncRNA-mediated (GO:0040033)2.65687586
136regulation of translation, ncRNA-mediated (GO:0045974)2.65687586
137negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.65687586
138telomere maintenance (GO:0000723)2.65359903
139spliceosomal snRNP assembly (GO:0000387)2.64575443
140base-excision repair (GO:0006284)2.64338771
141transcription initiation from RNA polymerase I promoter (GO:0006361)2.64275484
142maturation of SSU-rRNA (GO:0030490)2.64260240
143meiotic cell cycle process (GO:1903046)2.63570368
144mitotic nuclear envelope disassembly (GO:0007077)2.62817469
145DNA replication (GO:0006260)2.62618751
146DNA topological change (GO:0006265)2.62313693
147sperm motility (GO:0030317)2.62208850
148regulation of DNA endoreduplication (GO:0032875)2.61932465
149L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.61781942
150RNA-dependent DNA replication (GO:0006278)2.61712477
151DNA-templated transcription, termination (GO:0006353)2.61650438
152ribonucleoprotein complex biogenesis (GO:0022613)2.61592211
153telomere organization (GO:0032200)2.61510345
154fucose catabolic process (GO:0019317)2.61221886
155L-fucose metabolic process (GO:0042354)2.61221886
156L-fucose catabolic process (GO:0042355)2.61221886
157axoneme assembly (GO:0035082)2.59785671
158RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.57403561
159DNA modification (GO:0006304)2.56673666
160DNA methylation or demethylation (GO:0044728)2.56569412
161negative regulation of meiosis (GO:0045835)2.55570130
162peptidyl-lysine trimethylation (GO:0018023)2.55326180
163regulation of timing of cell differentiation (GO:0048505)2.54271941
164centrosome organization (GO:0051297)2.51379070
165regulation of hippo signaling (GO:0035330)2.50372187
166regulation of acrosome reaction (GO:0060046)2.50186628
167DNA recombination (GO:0006310)2.48932786
168regulation of cilium movement (GO:0003352)2.48694161
169sister chromatid cohesion (GO:0007062)2.47492408
170histone mRNA catabolic process (GO:0071044)2.46669576
171regulation of female gonad development (GO:2000194)2.46333569
172microtubule organizing center organization (GO:0031023)2.45168277
173methionine biosynthetic process (GO:0009086)2.44498161
174histone H3-K4 trimethylation (GO:0080182)2.43703157
175retinal cone cell development (GO:0046549)2.43299833
176inositol phosphate catabolic process (GO:0071545)2.42190569

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.75712593
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.12643806
3ZNF274_21170338_ChIP-Seq_K562_Hela4.11853423
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.50425683
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.20786311
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.19662591
7IGF1R_20145208_ChIP-Seq_DFB_Human3.12633091
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.08535056
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.96328581
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.87512824
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.66593628
12* EST1_17652178_ChIP-ChIP_JURKAT_Human2.62166499
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.55298449
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.54730799
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.50625749
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.50569653
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.38143625
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32053926
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.25628966
20FOXP3_21729870_ChIP-Seq_TREG_Human2.16710881
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14266903
22* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.14234946
23* ETS1_20019798_ChIP-Seq_JURKAT_Human2.12730480
24ER_23166858_ChIP-Seq_MCF-7_Human2.09051500
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07623456
26* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.06957634
27VDR_23849224_ChIP-Seq_CD4+_Human1.95359083
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.95066617
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92764684
30YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91510298
31VDR_22108803_ChIP-Seq_LS180_Human1.88023417
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.87917892
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.86720450
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84777455
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83034301
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.82731036
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.81279618
38POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.79627476
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.78925643
40* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.74846107
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74581365
42IRF1_19129219_ChIP-ChIP_H3396_Human1.72361035
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.72328659
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.71646936
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.70435576
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70169324
47ELK1_19687146_ChIP-ChIP_HELA_Human1.70159254
48* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65987567
49EZH2_22144423_ChIP-Seq_EOC_Human1.65490427
50MYC_18940864_ChIP-ChIP_HL60_Human1.64740462
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.63563307
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.62833603
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62244413
54XRN2_22483619_ChIP-Seq_HELA_Human1.57935243
55TTF2_22483619_ChIP-Seq_HELA_Human1.57570201
56P300_19829295_ChIP-Seq_ESCs_Human1.55973765
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.55744980
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55546468
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52886505
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52039256
61TAF15_26573619_Chip-Seq_HEK293_Human1.49888089
62* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49626236
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49004761
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47789836
65EWS_26573619_Chip-Seq_HEK293_Human1.47776133
66BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45401485
67STAT3_23295773_ChIP-Seq_U87_Human1.44379434
68DCP1A_22483619_ChIP-Seq_HELA_Human1.43850328
69* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43813185
70TP53_22573176_ChIP-Seq_HFKS_Human1.43330297
71IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.41126180
72* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38239879
73CIITA_25753668_ChIP-Seq_RAJI_Human1.38021062
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37222582
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36970431
76EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.34003741
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33922107
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32057362
79FUS_26573619_Chip-Seq_HEK293_Human1.30121189
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29289342
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27226841
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.27009627
83HOXB7_26014856_ChIP-Seq_BT474_Human1.25987135
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25148298
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24867909
86TCF4_23295773_ChIP-Seq_U87_Human1.24734972
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.24478684
88CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24397161
89SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23999000
90NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.22104922
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.21452358
92* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20564541
93AHR_22903824_ChIP-Seq_MCF-7_Human1.20013408
94KDM5A_27292631_Chip-Seq_BREAST_Human1.19696477
95* GABP_19822575_ChIP-Seq_HepG2_Human1.19324778
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18900531
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17361433
98* SMAD4_21799915_ChIP-Seq_A2780_Human1.14122817
99NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.13986452
100FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12447257
101CBP_20019798_ChIP-Seq_JUKART_Human1.12163647
102IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12163647
103GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11763905
104BCAT_22108803_ChIP-Seq_LS180_Human1.10954957
105FOXA1_25329375_ChIP-Seq_VCAP_Human1.08601806
106FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08601806
107TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08554084
108AR_25329375_ChIP-Seq_VCAP_Human1.07472408
109CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06407476
110CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05356368
111RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04665511
112GATA3_21878914_ChIP-Seq_MCF-7_Human1.03476118
113TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03421963
114* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03121680
115SOX2_16153702_ChIP-ChIP_HESCs_Human1.02970553
116FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01435092
117ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01202323
118AR_20517297_ChIP-Seq_VCAP_Human1.00884503
119STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00871961
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00676323
121ESR1_20079471_ChIP-ChIP_T-47D_Human0.98617765
122SOX2_19829295_ChIP-Seq_ESCs_Human0.97560126
123NANOG_19829295_ChIP-Seq_ESCs_Human0.97560126
124SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97275935
125GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96987166
126SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95825766
127GBX2_23144817_ChIP-Seq_PC3_Human0.94330184
128* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93833756
129GATA3_26560356_Chip-Seq_TH2_Human0.93004935
130PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92579878
131TDRD3_21172665_ChIP-Seq_MCF-7_Human0.92410657
132KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91807884
133RUNX2_22187159_ChIP-Seq_PCA_Human0.91404680
134SMAD4_21741376_ChIP-Seq_EPCs_Human0.90835160
135TCF4_22108803_ChIP-Seq_LS180_Human0.90513683
136ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89958425
137NANOG_16153702_ChIP-ChIP_HESCs_Human0.88866531
138BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88822998
139DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85747092
140TCF3_18692474_ChIP-Seq_MESCs_Mouse0.84006435
141* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82640568
142EZH2_27294783_Chip-Seq_NPCs_Mouse0.81826119
143CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79551389
144AR_21909140_ChIP-Seq_LNCAP_Human0.79433317
145STAT3_18555785_Chip-Seq_ESCs_Mouse0.79142178
146PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.78814133
147EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.78575122
148BP1_19119308_ChIP-ChIP_Hs578T_Human0.78495076
149CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.77518900
150* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77486849
151IRF8_21731497_ChIP-ChIP_J774_Mouse0.77201098
152POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.75970461
153CBX2_27304074_Chip-Seq_ESCs_Mouse0.75894908
154RUNX1_27457419_Chip-Seq_LIVER_Mouse0.74933787

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair4.22159055
2MP0008057_abnormal_DNA_replication4.20500293
3MP0003693_abnormal_embryo_hatching4.12480024
4MP0006292_abnormal_olfactory_placode4.11497154
5MP0010094_abnormal_chromosome_stability3.68348054
6MP0003111_abnormal_nucleus_morphology3.56173092
7MP0008007_abnormal_cellular_replicative3.23603289
8MP0008877_abnormal_DNA_methylation2.88944171
9MP0003077_abnormal_cell_cycle2.86272317
10MP0001188_hyperpigmentation2.78306937
11MP0003787_abnormal_imprinting2.62567004
12MP0004957_abnormal_blastocyst_morpholog2.53254521
13MP0000372_irregular_coat_pigmentation2.37328637
14MP0003941_abnormal_skin_development2.17073009
15MP0008932_abnormal_embryonic_tissue2.11732450
16MP0002396_abnormal_hematopoietic_system2.07580801
17MP0005410_abnormal_fertilization2.00192706
18MP0003315_abnormal_perineum_morphology1.84581585
19MP0002638_abnormal_pupillary_reflex1.80158999
20MP0000427_abnormal_hair_cycle1.78215923
21MP0003121_genomic_imprinting1.76132389
22MP0003646_muscle_fatigue1.75374825
23MP0003123_paternal_imprinting1.72636789
24MP0001919_abnormal_reproductive_system1.72001971
25MP0003786_premature_aging1.69002434
26MP0002102_abnormal_ear_morphology1.60486405
27MP0008995_early_reproductive_senescence1.59957671
28MP0000566_synostosis1.53132275
29MP0004147_increased_porphyrin_level1.49807053
30MP0000383_abnormal_hair_follicle1.49684407
31MP0003698_abnormal_male_reproductive1.44085596
32MP0005551_abnormal_eye_electrophysiolog1.44055618
33MP0002876_abnormal_thyroid_physiology1.42330440
34MP0010030_abnormal_orbit_morphology1.41513961
35MP0008872_abnormal_physiological_respon1.37990541
36MP0003136_yellow_coat_color1.36557930
37MP0000490_abnormal_crypts_of1.36190024
38MP0004084_abnormal_cardiac_muscle1.35403051
39MP0000049_abnormal_middle_ear1.34855225
40MP0008789_abnormal_olfactory_epithelium1.34802842
41MP0009697_abnormal_copulation1.33762836
42MP0001835_abnormal_antigen_presentation1.33638994
43MP0005174_abnormal_tail_pigmentation1.33576276
44MP0003950_abnormal_plasma_membrane1.31085613
45MP0000678_abnormal_parathyroid_gland1.28136922
46MP0010386_abnormal_urinary_bladder1.27416212
47MP0005253_abnormal_eye_physiology1.26269735
48MP0004043_abnormal_pH_regulation1.26040576
49MP0001293_anophthalmia1.25742493
50MP0002160_abnormal_reproductive_system1.25617164
51MP0008961_abnormal_basal_metabolism1.25205597
52MP0002938_white_spotting1.25179477
53MP0002210_abnormal_sex_determination1.19891315
54MP0002009_preneoplasia1.19478338
55MP0002163_abnormal_gland_morphology1.18860701
56MP0005671_abnormal_response_to1.17252004
57MP0001119_abnormal_female_reproductive1.17089446
58MP0002132_abnormal_respiratory_system1.15952711
59MP0002234_abnormal_pharynx_morphology1.14418353
60MP0005395_other_phenotype1.13808897
61MP0001672_abnormal_embryogenesis/_devel1.12388206
62MP0005380_embryogenesis_phenotype1.12388206
63MP0002928_abnormal_bile_duct1.11572157
64MP0001986_abnormal_taste_sensitivity1.10503893
65MP0009703_decreased_birth_body1.08095939
66MP0000631_abnormal_neuroendocrine_gland1.07215794
67MP0000313_abnormal_cell_death1.07139396
68MP0000350_abnormal_cell_proliferation1.05937136
69MP0005075_abnormal_melanosome_morpholog1.04765617
70MP0002736_abnormal_nociception_after1.03533240
71MP0003119_abnormal_digestive_system1.00486554
72MP0006072_abnormal_retinal_apoptosis1.00066396
73MP0003718_maternal_effect0.97854461
74MP0003880_abnormal_central_pattern0.97283938
75MP0002148_abnormal_hypersensitivity_rea0.95384100
76MP0003763_abnormal_thymus_physiology0.94653412
77MP0000516_abnormal_urinary_system0.94413227
78MP0005367_renal/urinary_system_phenotyp0.94413227
79MP0005394_taste/olfaction_phenotype0.94184094
80MP0005499_abnormal_olfactory_system0.94184094
81MP0003699_abnormal_female_reproductive0.93555361
82MP0001529_abnormal_vocalization0.92971020
83MP0002277_abnormal_respiratory_mucosa0.91980656
84MP0003937_abnormal_limbs/digits/tail_de0.91680977
85MP0009672_abnormal_birth_weight0.91599537
86MP0002161_abnormal_fertility/fecundity0.90550451
87MP0001929_abnormal_gametogenesis0.90224192
88MP0002398_abnormal_bone_marrow0.89302129
89MP0004808_abnormal_hematopoietic_stem0.88576973
90MP0010678_abnormal_skin_adnexa0.88390890
91MP0001286_abnormal_eye_development0.88315253
92MP0001984_abnormal_olfaction0.87498427
93MP0003890_abnormal_embryonic-extraembry0.87243183
94MP0004133_heterotaxia0.86606611
95MP0003984_embryonic_growth_retardation0.86381862
96MP0000358_abnormal_cell_content/0.86112821
97MP0001145_abnormal_male_reproductive0.85945967
98MP0006276_abnormal_autonomic_nervous0.85125513
99MP0002751_abnormal_autonomic_nervous0.85121991
100MP0005171_absent_coat_pigmentation0.84468398
101MP0005646_abnormal_pituitary_gland0.84392512
102MP0001348_abnormal_lacrimal_gland0.84025610
103MP0006035_abnormal_mitochondrial_morpho0.83743180
104MP0000703_abnormal_thymus_morphology0.83164544
105MP0000653_abnormal_sex_gland0.82007424
106MP0002088_abnormal_embryonic_growth/wei0.81739880
107MP0002735_abnormal_chemical_nociception0.81017570
108MP0002085_abnormal_embryonic_tissue0.80662024
109MP0003828_pulmonary_edema0.80565236
110MP0002095_abnormal_skin_pigmentation0.79265853
111MP0003656_abnormal_erythrocyte_physiolo0.79005026
112MP0005266_abnormal_metabolism0.78812826
113MP0003943_abnormal_hepatobiliary_system0.78625117
114MP0008775_abnormal_heart_ventricle0.76954531
115MP0005310_abnormal_salivary_gland0.76826825
116MP0004142_abnormal_muscle_tone0.76610195
117MP0002909_abnormal_adrenal_gland0.76421092
118MP0005389_reproductive_system_phenotype0.76271501
119MP0001697_abnormal_embryo_size0.75484155
120MP0000026_abnormal_inner_ear0.74245041
121MP0009053_abnormal_anal_canal0.73655292
122MP0000647_abnormal_sebaceous_gland0.73418932
123MP0002019_abnormal_tumor_incidence0.73307944
124MP0002653_abnormal_ependyma_morphology0.72637400
125MP0010307_abnormal_tumor_latency0.72512686
126MP0005083_abnormal_biliary_tract0.72193227
127MP0001968_abnormal_touch/_nociception0.71911586
128MP0001730_embryonic_growth_arrest0.71808471
129MP0003936_abnormal_reproductive_system0.71479487
130MP0001764_abnormal_homeostasis0.69354579
131MP0003195_calcinosis0.69277096
132MP0004484_altered_response_of0.69091302
133MP0000538_abnormal_urinary_bladder0.68625747
134MP0002249_abnormal_larynx_morphology0.68455255
135MP0001324_abnormal_eye_pigmentation0.68235994
136MP0000689_abnormal_spleen_morphology0.66539340
137MP0000013_abnormal_adipose_tissue0.65605786
138MP0009785_altered_susceptibility_to0.65346111
139MP0002722_abnormal_immune_system0.65255572
140MP0002086_abnormal_extraembryonic_tissu0.64896676
141MP0000015_abnormal_ear_pigmentation0.64725474
142MP0000858_altered_metastatic_potential0.64609521
143MP0005391_vision/eye_phenotype0.64565006
144MP0002127_abnormal_cardiovascular_syste0.64312068
145MP0002084_abnormal_developmental_patter0.64289256
146MP0004197_abnormal_fetal_growth/weight/0.64011202
147MP0005379_endocrine/exocrine_gland_phen0.63557256
148MP0003938_abnormal_ear_development0.62877733
149MP0004233_abnormal_muscle_weight0.60093901
150MP0002233_abnormal_nose_morphology0.60093584

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.31257007
2Chromsome breakage (HP:0040012)5.22737837
3Aplasia/Hypoplasia of the uvula (HP:0010293)3.92935978
4Molar tooth sign on MRI (HP:0002419)3.72948771
5Abnormality of midbrain morphology (HP:0002418)3.72948771
6Meckel diverticulum (HP:0002245)3.54401121
7Abnormality of the preputium (HP:0100587)3.41992364
8Abnormality of the ileum (HP:0001549)3.40907501
9Agnosia (HP:0010524)3.32432460
10Type II lissencephaly (HP:0007260)3.25142041
11Pancreatic fibrosis (HP:0100732)3.21845551
12Chronic hepatic failure (HP:0100626)3.15296879
13Duplicated collecting system (HP:0000081)3.08703315
14Volvulus (HP:0002580)3.04632944
15Abnormality of chromosome stability (HP:0003220)3.02311071
16True hermaphroditism (HP:0010459)3.00534012
17Abnormality of DNA repair (HP:0003254)2.99668944
18Birth length less than 3rd percentile (HP:0003561)2.93986447
19Ectopic kidney (HP:0000086)2.92982764
20Abnormality of the renal collecting system (HP:0004742)2.88628481
21Reticulocytopenia (HP:0001896)2.85149746
22Abnormality of the renal cortex (HP:0011035)2.80671678
23Medulloblastoma (HP:0002885)2.76867282
24Cerebellar dysplasia (HP:0007033)2.76662812
25Aplasia/Hypoplasia of the sacrum (HP:0008517)2.69281118
26Abnormality of the pons (HP:0007361)2.59331272
27Medial flaring of the eyebrow (HP:0010747)2.59187871
28Oligodactyly (hands) (HP:0001180)2.57746789
29Clubbing of toes (HP:0100760)2.57268649
30Renal cortical cysts (HP:0000803)2.56785880
31Myelodysplasia (HP:0002863)2.53766003
32Aplastic anemia (HP:0001915)2.50061644
33Lissencephaly (HP:0001339)2.49633467
34Bone marrow hypocellularity (HP:0005528)2.48216171
35Microretrognathia (HP:0000308)2.47911432
36Duodenal stenosis (HP:0100867)2.47837142
37Small intestinal stenosis (HP:0012848)2.47837142
38Supernumerary spleens (HP:0009799)2.46837158
39Dyschromatopsia (HP:0007641)2.45314140
40Patellar aplasia (HP:0006443)2.45016848
41Aplasia/Hypoplasia of the tongue (HP:0010295)2.44241706
42Aplasia/Hypoplasia of the fovea (HP:0008060)2.39153020
43Hypoplasia of the fovea (HP:0007750)2.39153020
44Type I transferrin isoform profile (HP:0003642)2.38980410
45Rib fusion (HP:0000902)2.38269086
46Colon cancer (HP:0003003)2.38168358
47Abnormality of the renal medulla (HP:0100957)2.36815228
48Nephroblastoma (Wilms tumor) (HP:0002667)2.35482040
49Hyperventilation (HP:0002883)2.35481825
50Astigmatism (HP:0000483)2.30934502
5111 pairs of ribs (HP:0000878)2.30632988
52Absent thumb (HP:0009777)2.29257076
53Aplasia/Hypoplasia of the patella (HP:0006498)2.25814202
54Bile duct proliferation (HP:0001408)2.25337679
55Abnormal biliary tract physiology (HP:0012439)2.25337679
56Hypoplasia of the pons (HP:0012110)2.24603111
57Hypoplastic pelvis (HP:0008839)2.23804749
58Hypothermia (HP:0002045)2.18845574
59Abnormality of the duodenum (HP:0002246)2.17614903
60Embryonal renal neoplasm (HP:0011794)2.16355909
61Facial hemangioma (HP:0000329)2.15875970
62Short thumb (HP:0009778)2.15453707
63Triphalangeal thumb (HP:0001199)2.14789426
64Congenital stationary night blindness (HP:0007642)2.14636539
65Abnormal number of incisors (HP:0011064)2.14181429
66Abnormal drinking behavior (HP:0030082)2.14156221
67Polydipsia (HP:0001959)2.14156221
68Tented upper lip vermilion (HP:0010804)2.14078268
69Microvesicular hepatic steatosis (HP:0001414)2.13517569
70Short middle phalanx of the 5th finger (HP:0004220)2.12624034
71Duplication of thumb phalanx (HP:0009942)2.11695941
72Abnormality of the fovea (HP:0000493)2.10729228
73Pancreatic cysts (HP:0001737)2.08200925
74Oral leukoplakia (HP:0002745)2.07973340
75Septo-optic dysplasia (HP:0100842)2.05295037
76Abnormal lung lobation (HP:0002101)2.03879332
77Congenital primary aphakia (HP:0007707)2.03876104
78Abnormal rod and cone electroretinograms (HP:0008323)2.01098111
79Aplasia/Hypoplasia of the tibia (HP:0005772)2.00512653
80Abnormality of the carotid arteries (HP:0005344)2.00279229
81Retrobulbar optic neuritis (HP:0100654)2.00025517
82Optic neuritis (HP:0100653)2.00025517
83Prostate neoplasm (HP:0100787)1.99615656
84Genital tract atresia (HP:0001827)1.99497045
85Disproportionate short-trunk short stature (HP:0003521)1.99196467
86Increased number of teeth (HP:0011069)1.97716317
87Abnormality of lateral ventricle (HP:0030047)1.97645335
88Pachygyria (HP:0001302)1.97390878
89Bony spicule pigmentary retinopathy (HP:0007737)1.97324486
90Impulsivity (HP:0100710)1.96594668
91Capillary hemangiomas (HP:0005306)1.96586789
92Ependymoma (HP:0002888)1.96285433
93Febrile seizures (HP:0002373)1.96172055
94Dandy-Walker malformation (HP:0001305)1.95957490
95Attenuation of retinal blood vessels (HP:0007843)1.94534219
96Reduced antithrombin III activity (HP:0001976)1.94123263
97Oligodactyly (HP:0012165)1.93799960
98Sloping forehead (HP:0000340)1.93284205
99Cystic liver disease (HP:0006706)1.92482220
100Abnormality of the incisor (HP:0000676)1.92338661
101Gait imbalance (HP:0002141)1.91896655
102Aplasia/Hypoplasia of the spleen (HP:0010451)1.89496021
103Nephronophthisis (HP:0000090)1.88790257
104Abnormality of the nasal septum (HP:0000419)1.88788870
105Absent radius (HP:0003974)1.88125388
106Hypoproteinemia (HP:0003075)1.86123587
107Intestinal fistula (HP:0100819)1.86001822
108Broad alveolar ridges (HP:0000187)1.85032199
109Nephrogenic diabetes insipidus (HP:0009806)1.85001555
110Thyroid-stimulating hormone excess (HP:0002925)1.84846497
111Short tibia (HP:0005736)1.84786049
112Poor coordination (HP:0002370)1.84503511
113Abnormality of the intervertebral disk (HP:0005108)1.84179766
114Fair hair (HP:0002286)1.83710026
115Mesomelia (HP:0003027)1.83337484
116Optic nerve coloboma (HP:0000588)1.83189242
117Hypoplasia of the thymus (HP:0000778)1.82849954
1183-Methylglutaconic aciduria (HP:0003535)1.81990371
119Vaginal atresia (HP:0000148)1.81508453
120Postaxial foot polydactyly (HP:0001830)1.80652129
121Thyroiditis (HP:0100646)1.80286763
122Hyperalaninemia (HP:0003348)1.79951303
123Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79951303
124Abnormality of alanine metabolism (HP:0010916)1.79951303
125Facial cleft (HP:0002006)1.77667642
126Absent forearm bone (HP:0003953)1.77280994
127Aplasia involving forearm bones (HP:0009822)1.77280994
128Tubular atrophy (HP:0000092)1.76537659
129Homocystinuria (HP:0002156)1.76305752
130Abnormality of homocysteine metabolism (HP:0010919)1.76305752
131Abnormality of the fingertips (HP:0001211)1.75532215
132Small hand (HP:0200055)1.75043264
133Amaurosis fugax (HP:0100576)1.74860484
134Premature graying of hair (HP:0002216)1.74304096
135Increased IgM level (HP:0003496)1.73629239
136Urethral obstruction (HP:0000796)1.73547798
137Long eyelashes (HP:0000527)1.72984490
138Intestinal atresia (HP:0011100)1.71388818
139Anencephaly (HP:0002323)1.71030070
140Dynein arm defect of respiratory motile cilia (HP:0012255)1.69679895
141Absent/shortened dynein arms (HP:0200106)1.69679895
142Missing ribs (HP:0000921)1.69621045
143Abnormality of the septum pellucidum (HP:0007375)1.69287849
144Aplasia cutis congenita (HP:0001057)1.69271710
145Preaxial hand polydactyly (HP:0001177)1.69002080
146Prominent metopic ridge (HP:0005487)1.68999191
147Optic nerve hypoplasia (HP:0000609)1.68907581
148Neoplasm of the oral cavity (HP:0100649)1.68397454
149Rectal fistula (HP:0100590)1.66952502
150Rectovaginal fistula (HP:0000143)1.66952502
151Horseshoe kidney (HP:0000085)1.66179413
152Generalized hypopigmentation of hair (HP:0011358)1.65606252
153Gaze-evoked nystagmus (HP:0000640)1.65315414
154Hypoplastic iliac wings (HP:0002866)1.65260313
155Stomach cancer (HP:0012126)1.65214359
156Degeneration of anterior horn cells (HP:0002398)1.64572831
157Abnormality of the anterior horn cell (HP:0006802)1.64572831
158Pendular nystagmus (HP:0012043)1.64526740
159Tracheoesophageal fistula (HP:0002575)1.64430674
160Asplenia (HP:0001746)1.63683581
161Abnormal hair whorl (HP:0010721)1.63285952
162Alveolar cell carcinoma (HP:0006519)1.61908561
163Bifid tongue (HP:0010297)1.60654143
164Deep philtrum (HP:0002002)1.59617633
165Cleft eyelid (HP:0000625)1.56626331
166Abnormality of the labia minora (HP:0012880)1.55548387
167Absent septum pellucidum (HP:0001331)1.55011221
168Pallor (HP:0000980)1.54868468

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.62339685
2TRIM283.51136744
3VRK23.17282490
4BRD43.03153012
5PLK43.00323309
6CDK122.86497775
7SRPK12.85708080
8BUB12.75950767
9ZAK2.67523187
10AKT32.44863463
11MKNK22.31630498
12STK162.22897248
13CDC72.22249079
14MAP2K72.18969503
15TXK2.14439156
16ACVR1B2.10425410
17TAOK32.01607263
18EIF2AK21.98337772
19TAOK21.96921576
20MKNK11.96727117
21VRK11.91890874
22WNK31.77932257
23TSSK61.71186880
24CDK71.69473699
25STK391.68236738
26WEE11.63822110
27EIF2AK11.63730469
28CASK1.61036793
29CDK81.58318482
30NEK21.54987757
31WNK41.52135651
32TAF11.51359243
33ATR1.51007017
34TTK1.49609257
35MUSK1.47630033
36TLK11.45906497
37PLK11.43047620
38EPHA41.42447143
39MAP4K21.37986708
40MAP3K141.35077535
41MAP3K61.33621100
42BRAF1.33513816
43NTRK31.30599719
44CSNK1G31.27717145
45CSNK1A1L1.26331903
46PASK1.20149941
47AURKB1.19964634
48YES11.18968253
49MAPKAPK31.18340283
50PLK31.16462251
51MAPKAPK51.16413752
52EPHA21.14440492
53PRPF4B1.14160674
54TGFBR11.14031144
55EIF2AK31.13838628
56CSNK1G11.13627291
57PIM21.12960893
58MAP3K41.09143424
59ADRBK21.07692272
60STK31.04252860
61DYRK31.03212157
62IRAK41.03030132
63ICK1.02938938
64CSNK1G21.01757327
65PINK11.01507607
66PTK2B0.99582779
67CDK90.98261249
68PAK30.95998221
69CHEK20.91775734
70PIK3CG0.90031884
71STK240.87781961
72MARK30.87579905
73STK380.86772997
74CHEK10.86704828
75DYRK20.85358467
76TNIK0.85334017
77RPS6KB10.83686213
78BMPR20.83219141
79STK40.82364722
80BRSK20.81403102
81PIM10.80936270
82MAP2K30.80490176
83IRAK30.79578754
84ATM0.76960091
85STK38L0.76176713
86MST40.76026312
87SIK30.74191900
88RPS6KA40.73482750
89CDK30.71321487
90AURKA0.71164530
91MAP3K30.69487195
92PRKCI0.67798846
93BCR0.67423105
94TEC0.67307584
95ITK0.66732492
96EPHA30.66289121
97IKBKB0.65360257
98CDK40.65104884
99RPS6KA50.64365861
100MAP3K50.63455955
101TRPM70.62360146
102NUAK10.62265612
103PNCK0.61720906
104PIK3CA0.61534393
105SGK20.60710051
106ERBB30.56726045
107FER0.52741245
108PLK20.52441240
109IRAK10.52089663
110GRK50.52006523
111GRK70.51831126
112MAPK130.51691591
113OXSR10.51026437
114INSRR0.50911637
115BRSK10.50640438
116PKN20.50194566
117PKN10.49018642
118RPS6KL10.48751955
119RPS6KC10.48751955
120MELK0.48150569
121CDK10.48067485
122CDK20.48034921
123CAMKK20.46647305
124SIK20.46517623
125MAP2K60.46014470
126CCNB10.45120854
127PRKCE0.44857804
128RPS6KA60.44846449
129NLK0.43363450
130FES0.43163596
131MAPK110.42641386
132KIT0.41509370
133CSNK2A10.41504327
134PBK0.40337825
135GRK10.40133074
136LYN0.39576119
137MAPK70.39510745
138CSNK1D0.38988551
139JAK30.38461782
140MATK0.38084233
141CHUK0.37648263
142NEK60.37138399
143BMPR1B0.36883673
144TIE10.34757845
145CAMK40.31955622
146TNK20.30770841

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.17050511
2DNA replication_Homo sapiens_hsa030303.90304457
3Homologous recombination_Homo sapiens_hsa034403.33595501
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.28994273
5Fanconi anemia pathway_Homo sapiens_hsa034603.26068784
6Base excision repair_Homo sapiens_hsa034103.25378685
7RNA polymerase_Homo sapiens_hsa030203.12524530
8Nucleotide excision repair_Homo sapiens_hsa034202.83566262
9One carbon pool by folate_Homo sapiens_hsa006702.74938904
10Spliceosome_Homo sapiens_hsa030402.71410130
11Non-homologous end-joining_Homo sapiens_hsa034502.54847925
12Ribosome_Homo sapiens_hsa030102.35413670
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.33415767
14RNA degradation_Homo sapiens_hsa030182.23677556
15Basal transcription factors_Homo sapiens_hsa030222.22153188
16Pyrimidine metabolism_Homo sapiens_hsa002402.21738867
17RNA transport_Homo sapiens_hsa030132.14753399
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.09509122
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.02525609
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.97420128
21Proteasome_Homo sapiens_hsa030501.94745610
22Cell cycle_Homo sapiens_hsa041101.92614397
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.65252543
24mRNA surveillance pathway_Homo sapiens_hsa030151.61899440
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.59980555
26Graft-versus-host disease_Homo sapiens_hsa053321.59051383
27Allograft rejection_Homo sapiens_hsa053301.58118726
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.56670347
29Systemic lupus erythematosus_Homo sapiens_hsa053221.46119750
30Propanoate metabolism_Homo sapiens_hsa006401.44393501
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.33026624
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.31659083
33Herpes simplex infection_Homo sapiens_hsa051681.30468134
34Purine metabolism_Homo sapiens_hsa002301.29560362
35Autoimmune thyroid disease_Homo sapiens_hsa053201.28948071
36Regulation of autophagy_Homo sapiens_hsa041401.28805777
37Butanoate metabolism_Homo sapiens_hsa006501.23232522
38Type I diabetes mellitus_Homo sapiens_hsa049401.17584417
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.12988836
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11556414
41Caffeine metabolism_Homo sapiens_hsa002321.09376540
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.09312119
43NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08912501
44p53 signaling pathway_Homo sapiens_hsa041151.08369028
45Olfactory transduction_Homo sapiens_hsa047401.02562187
46Lysine degradation_Homo sapiens_hsa003100.99067781
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97315547
48Primary immunodeficiency_Homo sapiens_hsa053400.95055891
49Hedgehog signaling pathway_Homo sapiens_hsa043400.94735214
50Epstein-Barr virus infection_Homo sapiens_hsa051690.93742488
51Steroid biosynthesis_Homo sapiens_hsa001000.93446218
52Measles_Homo sapiens_hsa051620.90249781
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86714559
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86519290
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84332826
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82597341
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81122579
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80558262
59Influenza A_Homo sapiens_hsa051640.78923071
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77986714
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77876334
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76573247
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.75955077
64Nitrogen metabolism_Homo sapiens_hsa009100.75790343
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75415208
66Hematopoietic cell lineage_Homo sapiens_hsa046400.74555586
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68154152
68Nicotine addiction_Homo sapiens_hsa050330.66973470
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65833285
70Linoleic acid metabolism_Homo sapiens_hsa005910.63112228
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61199596
72Basal cell carcinoma_Homo sapiens_hsa052170.61138241
73ABC transporters_Homo sapiens_hsa020100.60028243
74TGF-beta signaling pathway_Homo sapiens_hsa043500.58961247
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.55565968
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54399494
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54016861
78HTLV-I infection_Homo sapiens_hsa051660.52139168
79Hippo signaling pathway_Homo sapiens_hsa043900.51838357
80Colorectal cancer_Homo sapiens_hsa052100.51303531
81Circadian rhythm_Homo sapiens_hsa047100.50972336
82Vitamin B6 metabolism_Homo sapiens_hsa007500.50942380
83Viral carcinogenesis_Homo sapiens_hsa052030.50774428
84Huntingtons disease_Homo sapiens_hsa050160.50470710
85Dorso-ventral axis formation_Homo sapiens_hsa043200.50028863
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49535444
87Legionellosis_Homo sapiens_hsa051340.49454534
88Fatty acid elongation_Homo sapiens_hsa000620.49435837
89Asthma_Homo sapiens_hsa053100.47600253
90Thyroid cancer_Homo sapiens_hsa052160.46992224
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.46923757
92Selenocompound metabolism_Homo sapiens_hsa004500.45595976
93Alcoholism_Homo sapiens_hsa050340.45095766
94Apoptosis_Homo sapiens_hsa042100.44289827
95Sulfur relay system_Homo sapiens_hsa041220.42715389
96N-Glycan biosynthesis_Homo sapiens_hsa005100.41436382
97Vitamin digestion and absorption_Homo sapiens_hsa049770.41081785
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40843418
99Peroxisome_Homo sapiens_hsa041460.40319536
100Hepatitis B_Homo sapiens_hsa051610.40226700
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40072738
102Arachidonic acid metabolism_Homo sapiens_hsa005900.38688507
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36934491
104Protein export_Homo sapiens_hsa030600.36319107
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34219525
106Ovarian steroidogenesis_Homo sapiens_hsa049130.33408239
107TNF signaling pathway_Homo sapiens_hsa046680.33026195
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32992371
109Taste transduction_Homo sapiens_hsa047420.32778492
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31342735
111beta-Alanine metabolism_Homo sapiens_hsa004100.30804046
112MicroRNAs in cancer_Homo sapiens_hsa052060.30754007
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.30508588
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.30347429
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28997255
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28318052
117Rheumatoid arthritis_Homo sapiens_hsa053230.28305430
118Folate biosynthesis_Homo sapiens_hsa007900.27713436
119Leishmaniasis_Homo sapiens_hsa051400.26646016
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26326924
121Viral myocarditis_Homo sapiens_hsa054160.26287677
122T cell receptor signaling pathway_Homo sapiens_hsa046600.25143631
123African trypanosomiasis_Homo sapiens_hsa051430.24968993
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23327483
125Wnt signaling pathway_Homo sapiens_hsa043100.22677744
126Notch signaling pathway_Homo sapiens_hsa043300.22126011
127Melanoma_Homo sapiens_hsa052180.22026450
128Oxidative phosphorylation_Homo sapiens_hsa001900.20786356
129Antigen processing and presentation_Homo sapiens_hsa046120.19899194
130Pertussis_Homo sapiens_hsa051330.19270769
131Hepatitis C_Homo sapiens_hsa051600.18943566
132Metabolic pathways_Homo sapiens_hsa011000.18280132
133Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.17553920
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17331354
135Oocyte meiosis_Homo sapiens_hsa041140.16570546
136Fructose and mannose metabolism_Homo sapiens_hsa000510.14290553
137Phototransduction_Homo sapiens_hsa047440.13880763
138Pathways in cancer_Homo sapiens_hsa052000.13606189
139Sphingolipid metabolism_Homo sapiens_hsa006000.12730264
140Malaria_Homo sapiens_hsa051440.12390768
141FoxO signaling pathway_Homo sapiens_hsa040680.10885516
142Parkinsons disease_Homo sapiens_hsa050120.10607570

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