ADCK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.40391066
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.40391066
3antigen processing and presentation of endogenous antigen (GO:0019883)5.45150798
4amyloid precursor protein catabolic process (GO:0042987)5.00205070
5negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.38178385
6regulation of mammary gland epithelial cell proliferation (GO:0033599)4.27809797
7positive regulation of gamma-delta T cell activation (GO:0046645)4.06641664
8proline biosynthetic process (GO:0006561)3.82330975
9protein localization to endosome (GO:0036010)3.81569554
10sterol catabolic process (GO:0016127)3.76313904
11cholesterol catabolic process (GO:0006707)3.76313904
12pyrimidine-containing compound transmembrane transport (GO:0072531)3.75340944
13antigen processing and presentation via MHC class Ib (GO:0002475)3.71674389
14negative regulation of cell size (GO:0045792)3.46879892
15apoptotic process involved in morphogenesis (GO:0060561)3.44361991
16Golgi transport vesicle coating (GO:0048200)3.43832708
17COPI coating of Golgi vesicle (GO:0048205)3.43832708
18mannose metabolic process (GO:0006013)3.42839945
19glycosphingolipid catabolic process (GO:0046479)3.39768792
20regulation of early endosome to late endosome transport (GO:2000641)3.37323799
21amyloid precursor protein metabolic process (GO:0042982)3.31858616
22negative regulation of erythrocyte differentiation (GO:0045647)3.30632182
23exocrine pancreas development (GO:0031017)3.28568716
24pentose metabolic process (GO:0019321)3.23813677
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.19884982
26deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.16934782
27regulation of translational fidelity (GO:0006450)3.15789593
28valine metabolic process (GO:0006573)3.14918174
29endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.14689316
30ribosomal small subunit biogenesis (GO:0042274)3.11982719
31signal peptide processing (GO:0006465)3.08308801
32pinocytosis (GO:0006907)3.07665341
33regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.07536681
34regulation of gamma-delta T cell differentiation (GO:0045586)3.07294148
35rRNA transcription (GO:0009303)3.06114789
36response to peptidoglycan (GO:0032494)3.04987636
37positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.01480925
38vitamin transmembrane transport (GO:0035461)3.00940724
39glycolipid catabolic process (GO:0019377)2.95814891
40cellular response to arsenic-containing substance (GO:0071243)2.94731640
41positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.93998828
42epithelial cell differentiation involved in prostate gland development (GO:0060742)2.92521517
43regulation of gamma-delta T cell activation (GO:0046643)2.92491809
44amino sugar catabolic process (GO:0046348)2.88730045
45L-serine transport (GO:0015825)2.87253528
46L-phenylalanine metabolic process (GO:0006558)2.86240559
47erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.86240559
48L-phenylalanine catabolic process (GO:0006559)2.86198942
49erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.86198942
50response to thyroid hormone (GO:0097066)2.84851931
51positive regulation of triglyceride biosynthetic process (GO:0010867)2.82516415
52urea cycle (GO:0000050)2.81079029
53serine transport (GO:0032329)2.80869018
54cellular response to thyroid hormone stimulus (GO:0097067)2.79421835
55negative regulation of glycoprotein biosynthetic process (GO:0010561)2.78688613
56nucleobase-containing small molecule interconversion (GO:0015949)2.78227329
57mitochondrial fusion (GO:0008053)2.77376298
58lymph vessel development (GO:0001945)2.77320112
59barbed-end actin filament capping (GO:0051016)2.76077497
60regulation of apoptotic process involved in morphogenesis (GO:1902337)2.74374385
61regulation of superoxide anion generation (GO:0032928)2.73849989
62regulation of cholesterol biosynthetic process (GO:0045540)2.72397185
63T cell migration (GO:0072678)2.70527986
64protein maturation by protein folding (GO:0022417)2.66990645
65negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.64906469
66response to acidic pH (GO:0010447)2.64341157
67outflow tract septum morphogenesis (GO:0003148)2.62808380
68mammary gland epithelial cell differentiation (GO:0060644)2.62762549
69membrane protein intracellular domain proteolysis (GO:0031293)2.60566287
70pyrimidine nucleoside salvage (GO:0043097)2.60518869
71pyrimidine-containing compound salvage (GO:0008655)2.60518869
72regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.60018447
73mast cell activation (GO:0045576)2.59567604
74regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.58456393
75negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.57444199
76negative regulation of cell killing (GO:0031342)2.57444199
77pentose-phosphate shunt (GO:0006098)2.57305278
78mast cell activation involved in immune response (GO:0002279)2.57191018
79mast cell degranulation (GO:0043303)2.57191018
80spliceosomal tri-snRNP complex assembly (GO:0000244)2.55814924
81short-chain fatty acid metabolic process (GO:0046459)2.55314239
82tooth mineralization (GO:0034505)2.54649872
83positive regulation of Cdc42 GTPase activity (GO:0043089)2.54495123
84cellular protein complex localization (GO:0034629)2.53907713
85GDP-mannose metabolic process (GO:0019673)2.52640731
86activation of Rac GTPase activity (GO:0032863)2.50863041
87hyaluronan catabolic process (GO:0030214)2.50841432
88membrane protein ectodomain proteolysis (GO:0006509)2.50100138
89glucose 6-phosphate metabolic process (GO:0051156)2.49697272
90azole transport (GO:0045117)2.49369423
91activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.48374388
92endothelium development (GO:0003158)2.47982371
93folic acid metabolic process (GO:0046655)2.47062507
94proline metabolic process (GO:0006560)2.46974966
95urea metabolic process (GO:0019627)2.46418730
96regulation of isotype switching to IgG isotypes (GO:0048302)2.45592791
97cellular potassium ion homeostasis (GO:0030007)2.44733770
98very long-chain fatty acid metabolic process (GO:0000038)2.44724506
99regulation of chromatin binding (GO:0035561)2.44192126
100NADH metabolic process (GO:0006734)2.42710344
101intracellular estrogen receptor signaling pathway (GO:0030520)2.42446636
102histone arginine methylation (GO:0034969)2.42061975
103retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.41251303
104positive regulation of nuclease activity (GO:0032075)2.40787117
105ceramide catabolic process (GO:0046514)2.40681070
106cytoskeletal anchoring at plasma membrane (GO:0007016)2.39193699
107mitotic G1 DNA damage checkpoint (GO:0031571)2.39037975
108adherens junction assembly (GO:0034333)2.38974591
109regulation of cardioblast differentiation (GO:0051890)2.38956575
110protein complex localization (GO:0031503)2.38781631
111formation of translation preinitiation complex (GO:0001731)2.37289710
112negative regulation of glycoprotein metabolic process (GO:1903019)2.36213970
113modulation by symbiont of host cellular process (GO:0044068)2.35613524
114negative regulation of viral release from host cell (GO:1902187)2.35499810
115apoptotic cell clearance (GO:0043277)2.35303289
116nucleotide salvage (GO:0043173)2.35117180
117positive regulation of keratinocyte differentiation (GO:0045618)2.34870152
118positive regulation of B cell differentiation (GO:0045579)2.34512320
119oligosaccharide catabolic process (GO:0009313)2.33811801
120glucose catabolic process (GO:0006007)2.32749822
121adhesion of symbiont to host (GO:0044406)2.32338374
122negative T cell selection (GO:0043383)2.32310495
123peptidyl-tyrosine autophosphorylation (GO:0038083)2.31751780
124monosaccharide biosynthetic process (GO:0046364)2.30721299
125muscle cell fate commitment (GO:0042693)2.30003020
126positive thymic T cell selection (GO:0045059)2.29669676
127NIK/NF-kappaB signaling (GO:0038061)2.28746893
128mucosal-associated lymphoid tissue development (GO:0048537)2.28120709
129Peyers patch development (GO:0048541)2.28120709
130DNA unwinding involved in DNA replication (GO:0006268)2.28030651
131lipopolysaccharide-mediated signaling pathway (GO:0031663)2.27845947
132peptidyl-arginine omega-N-methylation (GO:0035247)2.27690428
133embryonic viscerocranium morphogenesis (GO:0048703)2.27292483
134activation of MAPKKK activity (GO:0000185)2.27291767
135alpha-linolenic acid metabolic process (GO:0036109)2.27268428
136low-density lipoprotein particle clearance (GO:0034383)2.26826271
137protein insertion into membrane (GO:0051205)2.26697460
138mitotic G1/S transition checkpoint (GO:0044819)2.25806093
139maternal placenta development (GO:0001893)2.25034502
140receptor catabolic process (GO:0032801)2.24899886
141regulation of triglyceride biosynthetic process (GO:0010866)2.24640175
142stress fiber assembly (GO:0043149)2.23646705
1434-hydroxyproline metabolic process (GO:0019471)2.23459760
144mitotic chromosome condensation (GO:0007076)2.23387796
145modulation by virus of host process (GO:0019054)2.23093004
146NADP metabolic process (GO:0006739)2.22786882
147negative thymic T cell selection (GO:0045060)2.19184986
148sulfur amino acid catabolic process (GO:0000098)2.19115217
149endosome to melanosome transport (GO:0035646)2.17136205
150endosome to pigment granule transport (GO:0043485)2.17136205
151reverse cholesterol transport (GO:0043691)2.17087870
152negative regulation of type 2 immune response (GO:0002829)2.17073701
153response to interleukin-15 (GO:0070672)2.16124265
154antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.14816941
155positive regulation of triglyceride metabolic process (GO:0090208)2.14508361
156regulation of actin nucleation (GO:0051125)2.14440790
157regulation of short-term neuronal synaptic plasticity (GO:0048172)2.14069837
158maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.12691939
159regulation of interleukin-12 biosynthetic process (GO:0045075)2.11666122
160positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.11517543
161branched-chain amino acid metabolic process (GO:0009081)2.10728465
162high-density lipoprotein particle remodeling (GO:0034375)2.10000838
163regulation of defense response to virus by virus (GO:0050690)2.09778018
164lymph node development (GO:0048535)2.09256852
165alanine transport (GO:0032328)2.08501527
166cellular extravasation (GO:0045123)2.08062208
167platelet dense granule organization (GO:0060155)2.06507702
168positive regulation of insulin secretion (GO:0032024)2.06244615
169peroxisomal transport (GO:0043574)2.05730626
170megakaryocyte development (GO:0035855)2.05605965
171negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.05451984
172T cell receptor signaling pathway (GO:0050852)2.05399790
173thymic T cell selection (GO:0045061)2.05148884
174cellular modified amino acid catabolic process (GO:0042219)2.04396575
175mannosylation (GO:0097502)2.03651503
176regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.02944205
177cellular ketone body metabolic process (GO:0046950)2.02390117
178positive T cell selection (GO:0043368)2.02158564
179regulation of triglyceride metabolic process (GO:0090207)2.01238495
180peroxisome organization (GO:0007031)2.01191506
181ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.01090494
182neurotransmitter-gated ion channel clustering (GO:0072578)2.00962192
183protein retention in ER lumen (GO:0006621)2.00927971
184positive regulation of respiratory burst (GO:0060267)1.99473422
185regulation of respiratory burst (GO:0060263)1.99049631
186nucleoside diphosphate catabolic process (GO:0009134)1.97859001
187nitric oxide mediated signal transduction (GO:0007263)1.97683892
188retrograde transport, vesicle recycling within Golgi (GO:0000301)1.97474044
189regulation of regulatory T cell differentiation (GO:0045589)1.97321561
190positive regulation of nitric-oxide synthase activity (GO:0051000)1.97227977
191fatty acid catabolic process (GO:0009062)1.97226592
192sodium ion export (GO:0071436)1.96918474

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.48997840
2SCL_19346495_ChIP-Seq_HPC-7_Human3.37668343
3RUNX_20019798_ChIP-Seq_JUKART_Human2.86168071
4LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.77374355
5RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.75581102
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.66944441
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.64296959
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.49344264
9* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.45720162
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.33470255
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.28885550
12RACK7_27058665_Chip-Seq_MCF-7_Human2.19579061
13E2F7_22180533_ChIP-Seq_HELA_Human2.17583107
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16209159
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.13701643
16RXR_22158963_ChIP-Seq_LIVER_Mouse2.10993775
17* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.08235858
18IKZF1_21737484_ChIP-ChIP_HCT116_Human2.04848011
19MYC_22102868_ChIP-Seq_BL_Human2.02268094
20VDR_24763502_ChIP-Seq_THP-1_Human1.95510064
21LXR_22292898_ChIP-Seq_THP-1_Human1.95288338
22PPARA_22158963_ChIP-Seq_LIVER_Mouse1.94636552
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.93639547
24VDR_21846776_ChIP-Seq_THP-1_Human1.93455118
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.92871228
26TET1_21451524_ChIP-Seq_MESCs_Mouse1.91501051
27GATA1_22025678_ChIP-Seq_K562_Human1.91018162
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.85498441
29MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.81222555
30LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.80029788
31DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.78820805
32* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.73765965
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.72812914
34GATA1_19941827_ChIP-Seq_MEL_Mouse1.67742712
35GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.67254672
36GATA1_19941826_ChIP-Seq_K562_Human1.64949150
37SRY_22984422_ChIP-ChIP_TESTIS_Rat1.63655112
38SPI1_23127762_ChIP-Seq_K562_Human1.63424356
39P68_20966046_ChIP-Seq_HELA_Human1.61884656
40TCF7_22412390_ChIP-Seq_EML_Mouse1.61620577
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.61474988
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.60724949
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.60468766
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59361212
45TAF15_26573619_Chip-Seq_HEK293_Human1.58983347
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58794704
47LXR_22158963_ChIP-Seq_LIVER_Mouse1.56329242
48DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.53870154
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53675352
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52612844
51FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.51406520
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.50357381
53UTX_26944678_Chip-Seq_JUKART_Human1.47404518
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.47391264
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.46765647
56MAF_26560356_Chip-Seq_TH1_Human1.46033551
57* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45629799
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.44895113
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44743321
60SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43295643
61CTCF_27219007_Chip-Seq_ERYTHROID_Human1.41765618
62ELF1_20517297_ChIP-Seq_JURKAT_Human1.41614964
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41570920
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.41562481
65* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40698793
66CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40682892
67ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.40555663
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39843570
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37596816
70FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.37444955
71EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36965721
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36213124
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36180050
74* XRN2_22483619_ChIP-Seq_HELA_Human1.35052354
75DROSHA_22980978_ChIP-Seq_HELA_Human1.34612227
76* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33775219
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33001796
78* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.32058931
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30297756
80SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30042149
81ESR2_21235772_ChIP-Seq_MCF-7_Human1.29505214
82SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28606991
83MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28569592
84ATF3_27146783_Chip-Seq_COLON_Human1.27090067
85* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26974397
86GATA3_27048872_Chip-Seq_THYMUS_Human1.26450420
87MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25857458
88BCOR_27268052_Chip-Seq_Bcells_Human1.24949787
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24887635
90KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24256035
91GATA2_21666600_ChIP-Seq_HMVEC_Human1.24246784
92BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23905359
93SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22152424
94GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21460693
95CREB1_26743006_Chip-Seq_LNCaP_Human1.21117500
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20976161
97MYB_26560356_Chip-Seq_TH2_Human1.20730497
98GATA2_19941826_ChIP-Seq_K562_Human1.20468268
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19470562
100* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18853999
101BCL6_27268052_Chip-Seq_Bcells_Human1.18385935
102SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18305621
103MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18258170
104CTCF_18555785_ChIP-Seq_MESCs_Mouse1.18026272
105STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17588130
106PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.17248939
107TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16892767
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16737097
109CTCF_26484167_Chip-Seq_Bcells_Mouse1.16657698
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16469600
111* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14640553
112STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.14527331
113KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14111484
114KDM2B_26808549_Chip-Seq_DND41_Human1.14056935
115JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.13968616
116PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13647537
117TFEB_21752829_ChIP-Seq_HELA_Human1.13302643
118KDM2B_26808549_Chip-Seq_JURKAT_Human1.13194478
119NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13164868
120MYB_26560356_Chip-Seq_TH1_Human1.12320050
121SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12275584
122STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12255970
123TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11788413
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10587731
125* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10490874
126ELK3_25401928_ChIP-Seq_HUVEC_Human1.10011570
127P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09660061
128RUNX1_22412390_ChIP-Seq_EML_Mouse1.08797899
129NCOR1_26117541_ChIP-Seq_K562_Human1.08488334
130ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08172975
131MYC_19030024_ChIP-ChIP_MESCs_Mouse1.06200505
132CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06188028
133* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06164021
134CTCF_21964334_Chip-Seq_Bcells_Human1.06160622
135EZH2_22144423_ChIP-Seq_EOC_Human1.05218554
136ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05154057
137* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03835534
138SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02129002
139SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02127528
140RARB_27405468_Chip-Seq_BRAIN_Mouse1.01717965
141RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01241897
142MAF_26560356_Chip-Seq_TH2_Human1.00231650
143SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.00124788
144ERG_21242973_ChIP-ChIP_JURKAT_Human1.00080414
145SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.99195159
146CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98196015
147MYB_21317192_ChIP-Seq_ERMYB_Mouse0.97670625
148NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97224908
149NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95119618
150EZH2_27294783_Chip-Seq_ESCs_Mouse0.94611202
151SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93555700
152* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92849975
153IRF8_27001747_Chip-Seq_BMDM_Mouse0.92143510
154REST_18959480_ChIP-ChIP_MESCs_Mouse0.92023603
155JARID2_20075857_ChIP-Seq_MESCs_Mouse0.91578867
156SA1_27219007_Chip-Seq_ERYTHROID_Human0.91183250
157* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90845722
158REST_21632747_ChIP-Seq_MESCs_Mouse0.89370642
159CLOCK_20551151_ChIP-Seq_293T_Human0.89083954
160ZNF263_19887448_ChIP-Seq_K562_Human0.88499437
161SMC4_20622854_ChIP-Seq_HELA_Human0.88463891
162CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.88402575
163SPI1_23547873_ChIP-Seq_NB4_Human0.87002533
164* KDM2B_26808549_Chip-Seq_K562_Human0.86899289

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.05022736
2MP0003705_abnormal_hypodermis_morpholog3.09116570
3MP0010234_abnormal_vibrissa_follicle2.93938094
4MP0005365_abnormal_bile_salt2.70689736
5MP0008260_abnormal_autophagy2.57613424
6MP0004185_abnormal_adipocyte_glucose2.39392167
7MP0004233_abnormal_muscle_weight2.39072068
8MP0000678_abnormal_parathyroid_gland2.33389237
9MP0003763_abnormal_thymus_physiology2.32746299
10MP0000685_abnormal_immune_system2.28000015
11MP0005671_abnormal_response_to2.25307777
12MP0009333_abnormal_splenocyte_physiolog2.20420314
13MP0003724_increased_susceptibility_to2.12275292
14MP0005464_abnormal_platelet_physiology2.09177588
15MP0002139_abnormal_hepatobiliary_system2.09082200
16MP0003303_peritoneal_inflammation2.07433694
17MP0002796_impaired_skin_barrier2.04122445
18MP0002909_abnormal_adrenal_gland2.04116950
19MP0005084_abnormal_gallbladder_morpholo2.03404220
20MP0003183_abnormal_peptide_metabolism2.01313437
21MP0001873_stomach_inflammation2.01164175
22MP0000013_abnormal_adipose_tissue2.00690771
23MP0008961_abnormal_basal_metabolism1.97340322
24MP0005075_abnormal_melanosome_morpholog1.93890335
25MP0002693_abnormal_pancreas_physiology1.93386432
26MP0003453_abnormal_keratinocyte_physiol1.91920252
27MP0003866_abnormal_defecation1.91497585
28MP0001986_abnormal_taste_sensitivity1.90130766
29MP0009840_abnormal_foam_cell1.84913647
30MP0005076_abnormal_cell_differentiation1.80641883
31MP0002166_altered_tumor_susceptibility1.78507461
32MP0000681_abnormal_thyroid_gland1.76034692
33MP0001835_abnormal_antigen_presentation1.74060635
34MP0009278_abnormal_bone_marrow1.69857037
35MP0004147_increased_porphyrin_level1.68561045
36MP0005058_abnormal_lysosome_morphology1.67516741
37MP0010329_abnormal_lipoprotein_level1.66066125
38MP0005174_abnormal_tail_pigmentation1.64864009
39MP0003329_amyloid_beta_deposits1.64544455
40MP0005646_abnormal_pituitary_gland1.64032484
41MP0005220_abnormal_exocrine_pancreas1.61714108
42MP0004859_abnormal_synaptic_plasticity1.59226976
43MP0005360_urolithiasis1.56749083
44MP0005501_abnormal_skin_physiology1.53719307
45MP0001790_abnormal_immune_system1.52776547
46MP0005387_immune_system_phenotype1.52776547
47MP0001944_abnormal_pancreas_morphology1.50544970
48MP0001800_abnormal_humoral_immune1.49827235
49MP0000465_gastrointestinal_hemorrhage1.48819106
50MP0004858_abnormal_nervous_system1.47910807
51MP0000537_abnormal_urethra_morphology1.47336538
52MP0005666_abnormal_adipose_tissue1.44667171
53MP0001849_ear_inflammation1.43304307
54MP0002249_abnormal_larynx_morphology1.40112269
55MP0005645_abnormal_hypothalamus_physiol1.39173056
56MP0004947_skin_inflammation1.39045298
57MP0002723_abnormal_immune_serum1.37578819
58MP0003880_abnormal_central_pattern1.36551586
59MP0005670_abnormal_white_adipose1.36253034
60MP0005375_adipose_tissue_phenotype1.34890798
61MP0005025_abnormal_response_to1.34751789
62MP0002090_abnormal_vision1.34525594
63MP0000015_abnormal_ear_pigmentation1.33979883
64MP0003656_abnormal_erythrocyte_physiolo1.32250755
65MP0002420_abnormal_adaptive_immunity1.32246873
66MP0005085_abnormal_gallbladder_physiolo1.31428391
67MP0009785_altered_susceptibility_to1.30892135
68MP0003075_altered_response_to1.30270636
69MP0005167_abnormal_blood-brain_barrier1.30267374
70MP0001819_abnormal_immune_cell1.29263994
71MP0001501_abnormal_sleep_pattern1.28984604
72MP0005000_abnormal_immune_tolerance1.26536732
73MP0002928_abnormal_bile_duct1.26257155
74MP0003172_abnormal_lysosome_physiology1.25635844
75MP0002452_abnormal_antigen_presenting1.25296597
76MP0005310_abnormal_salivary_gland1.24097824
77MP0008004_abnormal_stomach_pH1.23406152
78MP0001664_abnormal_digestion1.23020561
79MP0005379_endocrine/exocrine_gland_phen1.22560589
80MP0000858_altered_metastatic_potential1.22166028
81MP0003635_abnormal_synaptic_transmissio1.22000255
82MP0000609_abnormal_liver_physiology1.21112254
83MP0002118_abnormal_lipid_homeostasis1.21022003
84MP0002398_abnormal_bone_marrow1.20995945
85MP0002078_abnormal_glucose_homeostasis1.19862711
86MP0000604_amyloidosis1.19650568
87MP0002822_catalepsy1.17126867
88MP0000733_abnormal_muscle_development1.16982623
89MP0009643_abnormal_urine_homeostasis1.16008175
90MP0001666_abnormal_nutrient_absorption1.15825657
91MP0003436_decreased_susceptibility_to1.15601750
92MP0006276_abnormal_autonomic_nervous1.15028559
93MP0000003_abnormal_adipose_tissue1.14757434
94MP0004808_abnormal_hematopoietic_stem1.14092000
95MP0003111_abnormal_nucleus_morphology1.13834904
96MP0002638_abnormal_pupillary_reflex1.11407817
97MP0003693_abnormal_embryo_hatching1.11202064
98MP0004264_abnormal_extraembryonic_tissu1.09952637
99MP0003634_abnormal_glial_cell1.09277065
100MP0003633_abnormal_nervous_system1.08185794
101MP0005623_abnormal_meninges_morphology1.08005501
102MP0010386_abnormal_urinary_bladder1.07754050
103MP0003300_gastrointestinal_ulcer1.06941165
104MP0004381_abnormal_hair_follicle1.05721206
105MP0003806_abnormal_nucleotide_metabolis1.05689695
106MP0002419_abnormal_innate_immunity1.04986765
107MP0001502_abnormal_circadian_rhythm1.04798545
108MP0001845_abnormal_inflammatory_respons1.03103131
109MP0005535_abnormal_body_temperature1.02843969
110MP0000716_abnormal_immune_system1.02097390
111MP0008569_lethality_at_weaning1.01580713
112MP0001853_heart_inflammation1.00361732
113MP0003191_abnormal_cellular_cholesterol0.99969218
114MP0003123_paternal_imprinting0.98890647
115MP0001661_extended_life_span0.98464408
116MP0006054_spinal_hemorrhage0.98440112
117MP0009764_decreased_sensitivity_to0.98332019
118MP0003879_abnormal_hair_cell0.97643696
119MP0008469_abnormal_protein_level0.97326068
120MP0001216_abnormal_epidermal_layer0.97317069
121MP0002837_dystrophic_cardiac_calcinosis0.97005983
122MP0005409_darkened_coat_color0.96837548
123MP0002877_abnormal_melanocyte_morpholog0.96443305
124MP0000490_abnormal_crypts_of0.96435164
125MP0005397_hematopoietic_system_phenotyp0.96390388
126MP0001545_abnormal_hematopoietic_system0.96390388
127MP0010155_abnormal_intestine_physiology0.95852358
128MP0005334_abnormal_fat_pad0.95688044
129MP0001346_abnormal_lacrimal_gland0.95238525
130MP0010307_abnormal_tumor_latency0.94586048
131MP0008875_abnormal_xenobiotic_pharmacok0.94145458
132MP0003868_abnormal_feces_composition0.94026928
133MP0005332_abnormal_amino_acid0.93785789
134MP0002429_abnormal_blood_cell0.92570295
135MP0002009_preneoplasia0.92408807
136MP0002736_abnormal_nociception_after0.91706381
137MP0000747_muscle_weakness0.91597544
138MP0000689_abnormal_spleen_morphology0.91552832
139MP0002098_abnormal_vibrissa_morphology0.91502413
140MP0009745_abnormal_behavioral_response0.91469629
141MP0002064_seizures0.91279791
142MP0004510_myositis0.90459686
143MP0005166_decreased_susceptibility_to0.90310993
144MP0002272_abnormal_nervous_system0.89219761
145MP0002006_tumorigenesis0.89156873
146MP0001270_distended_abdomen0.89080369
147MP0009765_abnormal_xenobiotic_induced0.88834402
148MP0000313_abnormal_cell_death0.88811374
149MP0001730_embryonic_growth_arrest0.88211460
150MP0000343_altered_response_to0.87889264
151MP0000350_abnormal_cell_proliferation0.87130701
152MP0002132_abnormal_respiratory_system0.86524177
153MP0003077_abnormal_cell_cycle0.84631545
154MP0003566_abnormal_cell_adhesion0.82762140
155MP0002148_abnormal_hypersensitivity_rea0.81947535
156MP0002998_abnormal_bone_remodeling0.81549112
157MP0009053_abnormal_anal_canal0.81087704
158MP0009931_abnormal_skin_appearance0.78304890
159MP0003315_abnormal_perineum_morphology0.77178453
160MP0005621_abnormal_cell_physiology0.76402337
161MP0006082_CNS_inflammation0.75475390
162MP0002060_abnormal_skin_morphology0.73654985
163MP0002234_abnormal_pharynx_morphology0.72947417
164MP0010352_gastrointestinal_tract_polyps0.72673941
165MP0003091_abnormal_cell_migration0.72448856
166MP0001881_abnormal_mammary_gland0.69721053
167MP0001727_abnormal_embryo_implantation0.67850092
168MP0004957_abnormal_blastocyst_morpholog0.66412514
169MP0001348_abnormal_lacrimal_gland0.64272814
170MP0008874_decreased_physiological_sensi0.61841843
171MP0000703_abnormal_thymus_morphology0.61349882
172MP0002089_abnormal_postnatal_growth/wei0.61173589

Predicted human phenotypes

RankGene SetZ-score
1Mutism (HP:0002300)4.98821558
2Hypoglycemic coma (HP:0001325)3.82746298
3Hypoglycemic seizures (HP:0002173)3.64090190
4Symptomatic seizures (HP:0011145)3.56094506
5Abnormality of aromatic amino acid family metabolism (HP:0004338)3.47619045
6Ketosis (HP:0001946)3.22976621
7Hyperinsulinemic hypoglycemia (HP:0000825)3.12697332
8Growth hormone excess (HP:0000845)3.10627874
9Hyperlipoproteinemia (HP:0010980)3.07581105
10Ketoacidosis (HP:0001993)3.04108832
11Chronic otitis media (HP:0000389)3.04074626
12Dysostosis multiplex (HP:0000943)3.01077785
13Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.98335013
14Generalized aminoaciduria (HP:0002909)2.90924632
15Ragged-red muscle fibers (HP:0003200)2.79806277
16Broad distal phalanx of finger (HP:0009836)2.76560650
17Double outlet right ventricle (HP:0001719)2.75980871
18Congenital malformation of the right heart (HP:0011723)2.75980871
19Truncus arteriosus (HP:0001660)2.73931357
20Hyperacusis (HP:0010780)2.72410860
21Pancreatic islet-cell hyperplasia (HP:0004510)2.70740474
22Vertebral compression fractures (HP:0002953)2.70152493
23Abnormality of polysaccharide metabolism (HP:0011012)2.63360826
24Abnormality of glycosaminoglycan metabolism (HP:0004371)2.63360826
25Abnormality of mucopolysaccharide metabolism (HP:0011020)2.63360826
26Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.62755545
27Prolonged bleeding time (HP:0003010)2.59830652
28Abnormality of the distal phalanges of the toes (HP:0010182)2.59678988
29Achilles tendon contracture (HP:0001771)2.59522676
30Elevated erythrocyte sedimentation rate (HP:0003565)2.55222724
31Recurrent bacterial skin infections (HP:0005406)2.53644935
32Paraparesis (HP:0002385)2.52879112
33Mucopolysacchariduria (HP:0008155)2.52776097
34Urinary glycosaminoglycan excretion (HP:0003541)2.52776097
35Neurofibrillary tangles (HP:0002185)2.52171696
36Progressive muscle weakness (HP:0003323)2.48918402
37Purpura (HP:0000979)2.45292905
38Confusion (HP:0001289)2.44859470
39Prolonged neonatal jaundice (HP:0006579)2.43474501
40Hepatic necrosis (HP:0002605)2.42641524
41Supranuclear gaze palsy (HP:0000605)2.42330893
42Type II lissencephaly (HP:0007260)2.41969342
43Recurrent abscess formation (HP:0002722)2.41343365
44Progressive neurologic deterioration (HP:0002344)2.40273765
45Inability to walk (HP:0002540)2.38862368
46Xanthomatosis (HP:0000991)2.36564935
47Abnormality of the pancreatic islet cells (HP:0006476)2.34221379
48Abnormality of endocrine pancreas physiology (HP:0012093)2.34221379
49Neuronal loss in central nervous system (HP:0002529)2.33515735
50Hypothermia (HP:0002045)2.32904653
51Microvesicular hepatic steatosis (HP:0001414)2.31463804
52Abnormality of the thoracic spine (HP:0100711)2.31292058
53Hepatocellular necrosis (HP:0001404)2.31182900
54Abnormality of the Achilles tendon (HP:0005109)2.30670363
55Axonal loss (HP:0003447)2.29306943
56Stridor (HP:0010307)2.27591527
57Epistaxis (HP:0000421)2.27017431
58Agitation (HP:0000713)2.26626402
59Inflammation of the large intestine (HP:0002037)2.26555475
60Abnormal ventriculo-arterial connection (HP:0011563)2.25318109
61Transposition of the great arteries (HP:0001669)2.25318109
62Abnormal connection of the cardiac segments (HP:0011545)2.25318109
63Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.24650465
64Recurrent bronchitis (HP:0002837)2.23396790
65Hypertensive crisis (HP:0100735)2.22809238
66Papilledema (HP:0001085)2.22739690
67J-shaped sella turcica (HP:0002680)2.21565943
68Gastrointestinal inflammation (HP:0004386)2.21555335
69Thoracic kyphosis (HP:0002942)2.20525608
70Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.20464833
71Abnormal protein N-linked glycosylation (HP:0012347)2.20464833
72Abnormal protein glycosylation (HP:0012346)2.20464833
73Abnormal glycosylation (HP:0012345)2.20464833
74Gingival bleeding (HP:0000225)2.20325825
75Hyperthyroidism (HP:0000836)2.19632612
76Systemic lupus erythematosus (HP:0002725)2.19347525
77Bulbar palsy (HP:0001283)2.19157097
78Abnormality of fatty-acid metabolism (HP:0004359)2.18136781
79Increased IgE level (HP:0003212)2.15080977
80Severe visual impairment (HP:0001141)2.13586699
81Fatigue (HP:0012378)2.13268742
82Colitis (HP:0002583)2.10547099
83Hypokinesia (HP:0002375)2.10423478
84Menstrual irregularities (HP:0000858)2.09037744
85Increased cerebral lipofuscin (HP:0011813)2.08227895
86Vacuolated lymphocytes (HP:0001922)2.07281470
87Hyperparathyroidism (HP:0000843)2.06165745
88Loss of speech (HP:0002371)2.05768355
89Increased neuronal autofluorescent lipopigment (HP:0002074)2.05297489
90Thin bony cortex (HP:0002753)2.05021683
91Upper motor neuron abnormality (HP:0002127)2.04320739
92Craniofacial dystonia (HP:0012179)2.03647103
93Delayed CNS myelination (HP:0002188)2.03159770
94Torticollis (HP:0000473)2.02932840
95Abnormality of the heme biosynthetic pathway (HP:0010472)2.01535500
96Anxiety (HP:0000739)2.01482343
97Eczematoid dermatitis (HP:0000976)2.01177986
98Late onset (HP:0003584)2.01143182
99Interstitial pulmonary disease (HP:0006530)2.00217054
100Myositis (HP:0100614)1.98104276
101Large eyes (HP:0001090)1.98102894
102Aplasia/Hypoplasia of the sacrum (HP:0008517)1.97892964
103Abnormality of macrophages (HP:0004311)1.97776583
104Abnormal gallbladder physiology (HP:0012438)1.97480327
105Cholecystitis (HP:0001082)1.97480327
106Spinal canal stenosis (HP:0003416)1.96024223
107Psychosis (HP:0000709)1.95903146
108Retinal dysplasia (HP:0007973)1.95759230
109Insomnia (HP:0100785)1.95142419
110Nasal polyposis (HP:0100582)1.95119844
111Centrally nucleated skeletal muscle fibers (HP:0003687)1.94714639
112Menorrhagia (HP:0000132)1.94669560
113Abnormal platelet function (HP:0011869)1.94010588
114Impaired platelet aggregation (HP:0003540)1.94010588
115Focal dystonia (HP:0004373)1.93836646
116Rigidity (HP:0002063)1.93315553
117Chronic sinusitis (HP:0011109)1.93203950
118Ulnar bowing (HP:0003031)1.92525909
119Generalized hyperpigmentation (HP:0007440)1.92349494
120Joint swelling (HP:0001386)1.92146733
121Thrombocytosis (HP:0001894)1.90671077
122Cerebral inclusion bodies (HP:0100314)1.90659615
123Abnormality of the nasal mucosa (HP:0000433)1.89104455
124Testicular atrophy (HP:0000029)1.87582759
125Short nail (HP:0001799)1.87575177
126Large for gestational age (HP:0001520)1.86255079
127Polygenic inheritance (HP:0010982)1.84684042
128Abnormality of glycolipid metabolism (HP:0010969)1.84497989
129Abnormality of liposaccharide metabolism (HP:0010968)1.84497989
130Abnormality of glycosphingolipid metabolism (HP:0004343)1.84497989
131Retinal atrophy (HP:0001105)1.84329572
132Cardiomegaly (HP:0001640)1.84084799
133Brushfield spots (HP:0001088)1.83673353
134Abnormal delayed hypersensitivity skin test (HP:0002963)1.82953256
135Dementia (HP:0000726)1.82607946
136Septate vagina (HP:0001153)1.82598128
137Severe muscular hypotonia (HP:0006829)1.82327378
138Progressive inability to walk (HP:0002505)1.81935976
139Abnormality of the phalanges of the hallux (HP:0010057)1.81920570
140Hyperbilirubinemia (HP:0002904)1.81731312
141Hypercortisolism (HP:0001578)1.81476491
142Trismus (HP:0000211)1.81388247
143Unilateral renal agenesis (HP:0000122)1.80799126
144Abnormality of the distal phalanx of the thumb (HP:0009617)1.80455829
145Limb dystonia (HP:0002451)1.80213947
146Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.80209522
147Hypoplastic left heart (HP:0004383)1.80017891
148Abnormality of the umbilical cord (HP:0010881)1.79981019
149Microretrognathia (HP:0000308)1.79819935
150Seborrheic dermatitis (HP:0001051)1.79675203
151Bone pain (HP:0002653)1.78069164
152Flat acetabular roof (HP:0003180)1.77838760
153Increased serum ferritin (HP:0003281)1.77044346
154Depression (HP:0000716)1.75882700
155Personality changes (HP:0000751)1.75686786
156Decreased circulating renin level (HP:0003351)1.75665130
157Single umbilical artery (HP:0001195)1.75164462
158Abnormality of the fetal cardiovascular system (HP:0010948)1.75164462
159Abnormal umbilical cord blood vessels (HP:0011403)1.75164462
160IgM deficiency (HP:0002850)1.74597037
161Gastrointestinal stroma tumor (HP:0100723)1.74420864
162Abnormality of the gallbladder (HP:0005264)1.74297950
163Panhypogammaglobulinemia (HP:0003139)1.73936159
164Hypoplasia of the thymus (HP:0000778)1.73538626
165Premature skin wrinkling (HP:0100678)1.73107262
166Nuclear cataract (HP:0100018)1.72629785
167Cerebral aneurysm (HP:0004944)1.72181185
168Distal upper limb amyotrophy (HP:0007149)1.71162638
169Upper limb amyotrophy (HP:0009129)1.71162638
170Short clavicles (HP:0000894)1.70583212
171Abnormal large intestine physiology (HP:0012700)1.70460244
172Amyloidosis (HP:0011034)1.70208193
173Agammaglobulinemia (HP:0004432)1.70168924
174Spinal cord compression (HP:0002176)1.70122953
175Myopathic facies (HP:0002058)1.69842505
176Germ cell neoplasia (HP:0100728)1.68758245
177Sparse lateral eyebrow (HP:0005338)1.68178175
178Abnormality of carpal bone ossification (HP:0006257)1.66960023

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.57150752
2SMG14.41913414
3NME24.04759425
4BCKDK3.94590664
5MAP4K13.62328423
6ERN13.15033221
7MAP3K122.96852913
8IRAK32.52005114
9ICK2.44425099
10SIK12.37027518
11KIT2.34031695
12PRKD32.22989830
13TBK12.13315347
14PKN21.89487303
15ZAP701.87418411
16CDK191.84946192
17MAPK151.83853344
18IKBKE1.78157172
19ARAF1.76654656
20TAOK31.73330111
21CAMK1D1.68473172
22TXK1.67717527
23EEF2K1.66437334
24FGFR41.59208737
25FLT31.54456555
26SIK31.51892256
27MAP3K31.51688187
28MAP2K31.50620899
29CAMKK21.48157917
30ITK1.48093142
31TYK21.47131471
32JAK31.44326045
33CDK121.43782263
34TNIK1.38168975
35TAOK11.36680274
36SIK21.35948662
37CSF1R1.32473505
38TESK11.31489566
39SCYL21.29395855
40MAP3K131.28090241
41GRK61.26672712
42SYK1.26174947
43JAK11.24746976
44IRAK41.23007988
45MAPK121.21221342
46PDPK11.20208123
47MAP2K71.16279814
48TRIB31.16094545
49EPHA21.15952028
50RIPK41.15304669
51CAMK1G1.13802986
52MAPK111.13478728
53BRAF1.11857457
54HIPK21.11602924
55MAP3K141.11104188
56DYRK31.09891511
57KSR21.07254644
58VRK21.06784068
59BTK1.04110363
60EPHA41.03998359
61MAPKAPK31.03069355
62IRAK21.02691986
63PRKCH1.01743359
64ILK1.01696722
65MAPK71.01251013
66MAP2K21.01142342
67IRAK11.00674775
68PIM21.00477281
69FES0.97977876
70RIPK10.93436474
71ABL20.91581001
72KDR0.89811063
73TESK20.89728277
74LCK0.87037792
75MAP3K100.86678778
76PIK3CG0.85772380
77CDK70.84165165
78AURKA0.78894494
79MAPKAPK50.76600923
80TEC0.73687278
81MARK20.73640138
82RPS6KL10.73082893
83RPS6KC10.73082893
84MST1R0.72481974
85PTK60.72244201
86PAK40.70871883
87MAP3K80.70767546
88MTOR0.70590521
89CDK40.70119746
90MYLK0.70063499
91TGFBR20.70043451
92LYN0.69138822
93TAOK20.68892353
94PASK0.68850081
95NLK0.67625458
96DAPK30.66717017
97UHMK10.65941672
98TAF10.64488815
99MAP3K20.63341761
100RPS6KB20.62507088
101CDK80.61858486
102LRRK20.57863523
103CHEK20.57198024
104MAPK40.56800906
105DAPK10.56665259
106PRKG20.56253016
107HCK0.56114190
108MAP3K90.55933508
109MAP3K70.54668189
110MAP2K40.54474333
111CDK50.52503430
112PDK20.51744415
113AKT20.51686251
114MAP3K10.51027367
115TNK20.50370184
116PRKCI0.50179370
117RET0.48475313
118RPS6KA60.48229317
119JAK20.47832252
120PAK30.47016284
121BRSK10.46505863
122TTN0.46120823
123NTRK10.43856043
124CAMKK10.43308193
125PRPF4B0.42490714
126NTRK20.42333832
127CDK90.42290257
128MATK0.41450500
129TIE10.41053138
130BMX0.40867645
131CSNK1G30.40691747
132NTRK30.40556229
133MAP3K60.39699500
134TLK10.39381972
135RPS6KA20.38146238
136EPHB10.38047193
137PRKD20.38034035
138CDK60.37859646
139IKBKB0.37282290
140BLK0.35989185
141PDK10.35984427
142LATS20.34655427
143MELK0.34536702
144DYRK1B0.33565931
145CHUK0.33069066
146CDC42BPA0.32947029
147RPS6KA10.31985611
148PTK20.31976754
149MAP2K60.31364069
150FYN0.31171728
151MUSK0.30771158
152MAP3K110.29983067
153PHKG20.29844392
154PHKG10.29844392
155MINK10.29677734
156STK160.29588078
157DDR20.28889969
158LMTK20.27178222
159CLK10.26939025

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.70604106
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.61375506
3Protein export_Homo sapiens_hsa030602.51343574
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.23261807
5Sulfur metabolism_Homo sapiens_hsa009202.12864011
6Insulin secretion_Homo sapiens_hsa049111.95047392
7Non-small cell lung cancer_Homo sapiens_hsa052231.94908448
8Caffeine metabolism_Homo sapiens_hsa002321.93076388
9Pentose phosphate pathway_Homo sapiens_hsa000301.90608107
10Vitamin B6 metabolism_Homo sapiens_hsa007501.87644643
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.82781432
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81938654
13DNA replication_Homo sapiens_hsa030301.81759744
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.79383341
15Primary immunodeficiency_Homo sapiens_hsa053401.79334724
16Bladder cancer_Homo sapiens_hsa052191.71456253
17ABC transporters_Homo sapiens_hsa020101.71138020
18Chronic myeloid leukemia_Homo sapiens_hsa052201.67209558
19Cyanoamino acid metabolism_Homo sapiens_hsa004601.66969598
20Fructose and mannose metabolism_Homo sapiens_hsa000511.66020262
21Galactose metabolism_Homo sapiens_hsa000521.65243566
22Vitamin digestion and absorption_Homo sapiens_hsa049771.59835159
23Fatty acid degradation_Homo sapiens_hsa000711.58479483
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.56827258
25Other glycan degradation_Homo sapiens_hsa005111.54175591
26Prion diseases_Homo sapiens_hsa050201.53168011
27VEGF signaling pathway_Homo sapiens_hsa043701.50696057
28N-Glycan biosynthesis_Homo sapiens_hsa005101.50541323
29Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.48993339
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48921537
31Pancreatic cancer_Homo sapiens_hsa052121.47172950
32Fatty acid elongation_Homo sapiens_hsa000621.46625392
33Cocaine addiction_Homo sapiens_hsa050301.45197580
34Biosynthesis of amino acids_Homo sapiens_hsa012301.45042457
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.41945220
36Carbohydrate digestion and absorption_Homo sapiens_hsa049731.39374367
37Central carbon metabolism in cancer_Homo sapiens_hsa052301.36164291
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.35223413
39Base excision repair_Homo sapiens_hsa034101.32455758
40Propanoate metabolism_Homo sapiens_hsa006401.31505038
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26939857
42Endometrial cancer_Homo sapiens_hsa052131.24093993
43Bile secretion_Homo sapiens_hsa049761.23742550
44Vibrio cholerae infection_Homo sapiens_hsa051101.22005771
45Hematopoietic cell lineage_Homo sapiens_hsa046401.21677419
46Fatty acid metabolism_Homo sapiens_hsa012121.19853756
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18983054
48mTOR signaling pathway_Homo sapiens_hsa041501.18829244
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.18375076
50Systemic lupus erythematosus_Homo sapiens_hsa053221.18214972
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.16946792
52Lysosome_Homo sapiens_hsa041421.16866333
53Glioma_Homo sapiens_hsa052141.16470638
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.15794242
55Pancreatic secretion_Homo sapiens_hsa049721.15783858
56B cell receptor signaling pathway_Homo sapiens_hsa046621.14806452
57Notch signaling pathway_Homo sapiens_hsa043301.13910480
58Neurotrophin signaling pathway_Homo sapiens_hsa047221.09430238
59Folate biosynthesis_Homo sapiens_hsa007901.07333598
60Sphingolipid metabolism_Homo sapiens_hsa006001.04850465
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04722929
62Circadian entrainment_Homo sapiens_hsa047131.03053617
63Tryptophan metabolism_Homo sapiens_hsa003801.01733995
64Histidine metabolism_Homo sapiens_hsa003401.01486623
65Type II diabetes mellitus_Homo sapiens_hsa049301.01116577
66Longevity regulating pathway - mammal_Homo sapiens_hsa042111.00841356
67Insulin signaling pathway_Homo sapiens_hsa049101.00128692
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00050278
69Fatty acid biosynthesis_Homo sapiens_hsa000610.99125013
70GABAergic synapse_Homo sapiens_hsa047270.98549383
71Amphetamine addiction_Homo sapiens_hsa050310.98504204
72Ribosome_Homo sapiens_hsa030100.98339784
73Tuberculosis_Homo sapiens_hsa051520.97647016
74Carbon metabolism_Homo sapiens_hsa012000.97403179
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96020946
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.94290595
77Thyroid cancer_Homo sapiens_hsa052160.91565557
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.88125471
79Inositol phosphate metabolism_Homo sapiens_hsa005620.87767307
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87449303
81Peroxisome_Homo sapiens_hsa041460.87105775
82Butanoate metabolism_Homo sapiens_hsa006500.86642298
83Morphine addiction_Homo sapiens_hsa050320.84953419
84Renal cell carcinoma_Homo sapiens_hsa052110.84833515
85PPAR signaling pathway_Homo sapiens_hsa033200.84366198
86Viral carcinogenesis_Homo sapiens_hsa052030.84084290
87Synaptic vesicle cycle_Homo sapiens_hsa047210.83571794
88Olfactory transduction_Homo sapiens_hsa047400.83181547
89Apoptosis_Homo sapiens_hsa042100.82246430
90Toxoplasmosis_Homo sapiens_hsa051450.81799563
91Selenocompound metabolism_Homo sapiens_hsa004500.81279056
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80935678
93AMPK signaling pathway_Homo sapiens_hsa041520.80890410
94T cell receptor signaling pathway_Homo sapiens_hsa046600.80611379
95Insulin resistance_Homo sapiens_hsa049310.80106044
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79472253
97Hepatitis B_Homo sapiens_hsa051610.79443167
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78530718
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78423098
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.78414308
101Salivary secretion_Homo sapiens_hsa049700.75995255
102Hepatitis C_Homo sapiens_hsa051600.75987979
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74954326
104Osteoclast differentiation_Homo sapiens_hsa043800.73712717
105Taste transduction_Homo sapiens_hsa047420.72478455
106Dopaminergic synapse_Homo sapiens_hsa047280.72222969
107Cholinergic synapse_Homo sapiens_hsa047250.71032978
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70664091
109Staphylococcus aureus infection_Homo sapiens_hsa051500.70492960
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69989153
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69719176
112Arginine and proline metabolism_Homo sapiens_hsa003300.69456815
113Glutamatergic synapse_Homo sapiens_hsa047240.68944675
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68732414
115Pyrimidine metabolism_Homo sapiens_hsa002400.68082619
116Renin secretion_Homo sapiens_hsa049240.67815484
117Platelet activation_Homo sapiens_hsa046110.67437886
118ErbB signaling pathway_Homo sapiens_hsa040120.67393511
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67386071
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67018316
121Circadian rhythm_Homo sapiens_hsa047100.66992135
122Small cell lung cancer_Homo sapiens_hsa052220.65696598
123Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65157408
124HTLV-I infection_Homo sapiens_hsa051660.64958186
125Nicotine addiction_Homo sapiens_hsa050330.63747185
126Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63737742
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62974236
128Influenza A_Homo sapiens_hsa051640.62603061
129Complement and coagulation cascades_Homo sapiens_hsa046100.62452916
130Shigellosis_Homo sapiens_hsa051310.61847929
131Alcoholism_Homo sapiens_hsa050340.61820600
132Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61741262
133Endocytosis_Homo sapiens_hsa041440.60825396
134Phagosome_Homo sapiens_hsa041450.59737598
135Fat digestion and absorption_Homo sapiens_hsa049750.59192533
136Prostate cancer_Homo sapiens_hsa052150.58960173
137HIF-1 signaling pathway_Homo sapiens_hsa040660.58154985
138beta-Alanine metabolism_Homo sapiens_hsa004100.57574258
139Serotonergic synapse_Homo sapiens_hsa047260.56816482
140GnRH signaling pathway_Homo sapiens_hsa049120.55483140
141Colorectal cancer_Homo sapiens_hsa052100.55061262
142TNF signaling pathway_Homo sapiens_hsa046680.54804910
143Regulation of autophagy_Homo sapiens_hsa041400.54522417
144Salmonella infection_Homo sapiens_hsa051320.54079080
145Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53381360
146Thyroid hormone synthesis_Homo sapiens_hsa049180.53147750
147Sulfur relay system_Homo sapiens_hsa041220.52920974
148RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52750640
149Glycerophospholipid metabolism_Homo sapiens_hsa005640.52345051
150AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51338652
151Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51149071
152Phenylalanine metabolism_Homo sapiens_hsa003600.50879904
153Adipocytokine signaling pathway_Homo sapiens_hsa049200.50854330
154Herpes simplex infection_Homo sapiens_hsa051680.50015221
155Arginine biosynthesis_Homo sapiens_hsa002200.49831959
156Collecting duct acid secretion_Homo sapiens_hsa049660.49765509
157Jak-STAT signaling pathway_Homo sapiens_hsa046300.49749128
158Ovarian steroidogenesis_Homo sapiens_hsa049130.49240070
159Choline metabolism in cancer_Homo sapiens_hsa052310.48486666
160Calcium signaling pathway_Homo sapiens_hsa040200.46183716
161Alzheimers disease_Homo sapiens_hsa050100.46099309
162Acute myeloid leukemia_Homo sapiens_hsa052210.45931426
163Glucagon signaling pathway_Homo sapiens_hsa049220.44711107
164Measles_Homo sapiens_hsa051620.44522327
165Leishmaniasis_Homo sapiens_hsa051400.43805521
166Gastric acid secretion_Homo sapiens_hsa049710.43251655
167Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42212664
168Prolactin signaling pathway_Homo sapiens_hsa049170.41585458
169Estrogen signaling pathway_Homo sapiens_hsa049150.40922592
170Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38435329
171Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38334178
172Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38213900
173Long-term potentiation_Homo sapiens_hsa047200.38205106

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