ADCK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcoplasmic reticulum calcium ion transport (GO:0070296)9.62687388
2actin-mediated cell contraction (GO:0070252)8.83793177
3skeletal muscle contraction (GO:0003009)8.78484849
4regulation of skeletal muscle contraction (GO:0014819)8.47195781
5creatine metabolic process (GO:0006600)7.90851753
6regulation of relaxation of muscle (GO:1901077)7.29238273
7myofibril assembly (GO:0030239)6.95050471
8striated muscle contraction (GO:0006941)6.94528069
9actin filament-based movement (GO:0030048)6.55386796
10response to stimulus involved in regulation of muscle adaptation (GO:0014874)6.52424106
11sarcomere organization (GO:0045214)6.39451336
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.38683309
13L-phenylalanine catabolic process (GO:0006559)6.07073124
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.07073124
15L-phenylalanine metabolic process (GO:0006558)5.90901554
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.90901554
17regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.83746191
18response to muscle activity (GO:0014850)5.82911852
19cardiac muscle contraction (GO:0060048)5.71021646
20cardiac myofibril assembly (GO:0055003)5.55944439
21response to inactivity (GO:0014854)5.55552574
22lysine catabolic process (GO:0006554)5.45673504
23lysine metabolic process (GO:0006553)5.45673504
24glycogen catabolic process (GO:0005980)5.42886330
25skeletal muscle adaptation (GO:0043501)5.39272603
26skeletal muscle fiber development (GO:0048741)5.36935452
27aromatic amino acid family catabolic process (GO:0009074)5.33906389
28glucan catabolic process (GO:0009251)5.11528431
29glyoxylate metabolic process (GO:0046487)5.08291568
30kynurenine metabolic process (GO:0070189)5.07685843
31muscle contraction (GO:0006936)5.05732968
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.88914251
33triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.88799746
34cardiac muscle hypertrophy (GO:0003300)4.85872526
35myotube cell development (GO:0014904)4.85099089
36cellular polysaccharide catabolic process (GO:0044247)4.84928546
37fatty acid transmembrane transport (GO:1902001)4.83826479
38fatty acid beta-oxidation (GO:0006635)4.83799896
39carnitine shuttle (GO:0006853)4.83173525
40regulation of actin filament-based movement (GO:1903115)4.81330678
41alpha-linolenic acid metabolic process (GO:0036109)4.80909491
42glucan biosynthetic process (GO:0009250)4.79883568
43glycogen biosynthetic process (GO:0005978)4.79883568
442-oxoglutarate metabolic process (GO:0006103)4.78642237
45indole-containing compound catabolic process (GO:0042436)4.76026206
46indolalkylamine catabolic process (GO:0046218)4.76026206
47tryptophan catabolic process (GO:0006569)4.76026206
48actomyosin structure organization (GO:0031032)4.71109757
49bile acid biosynthetic process (GO:0006699)4.69422221
50cellular ketone body metabolic process (GO:0046950)4.69163227
51striated muscle hypertrophy (GO:0014897)4.64937414
52regulation of triglyceride catabolic process (GO:0010896)4.63753854
53regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.63063020
54amino-acid betaine metabolic process (GO:0006577)4.57047839
55muscle system process (GO:0003012)4.56543357
56aspartate family amino acid catabolic process (GO:0009068)4.48710192
57acetyl-CoA metabolic process (GO:0006084)4.47554589
58cysteine metabolic process (GO:0006534)4.47206727
59tryptophan metabolic process (GO:0006568)4.46008093
60fatty acid oxidation (GO:0019395)4.45959171
61short-chain fatty acid metabolic process (GO:0046459)4.45168308
62fatty acid catabolic process (GO:0009062)4.41805723
63regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.39504139
64sulfur amino acid catabolic process (GO:0000098)4.39367524
65polysaccharide catabolic process (GO:0000272)4.37983143
66regulation of cell communication by electrical coupling (GO:0010649)4.37529111
67lipid oxidation (GO:0034440)4.37074400
68muscle hypertrophy (GO:0014896)4.33084585
69striated muscle adaptation (GO:0014888)4.32735397
70tricarboxylic acid cycle (GO:0006099)4.28734470
71regulation of sequestering of triglyceride (GO:0010889)4.22986465
72urea metabolic process (GO:0019627)4.22194134
73urea cycle (GO:0000050)4.22194134
74serine family amino acid catabolic process (GO:0009071)4.22092416
75negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.18495104
76monocarboxylic acid catabolic process (GO:0072329)4.17829052
77valine metabolic process (GO:0006573)4.14421094
78branched-chain amino acid catabolic process (GO:0009083)4.14100055
79alpha-amino acid catabolic process (GO:1901606)4.12463777
80ketone body metabolic process (GO:1902224)4.07805824
81ethanol oxidation (GO:0006069)4.07271126
82complement activation, alternative pathway (GO:0006957)4.05697157
83muscle fiber development (GO:0048747)4.01444189
84negative regulation of fibrinolysis (GO:0051918)4.00933407
85high-density lipoprotein particle remodeling (GO:0034375)4.00695920
86carnitine metabolic process (GO:0009437)3.98836377
87homocysteine metabolic process (GO:0050667)3.95566860
88nitrogen cycle metabolic process (GO:0071941)3.93597553
89peptidyl-glutamic acid carboxylation (GO:0017187)3.93373403
90protein carboxylation (GO:0018214)3.93373403
91biotin metabolic process (GO:0006768)3.93221188
92gluconeogenesis (GO:0006094)3.93072811
93glycogen metabolic process (GO:0005977)3.92574081
94cellular amino acid catabolic process (GO:0009063)3.89410669
95regulation of protein activation cascade (GO:2000257)3.89235979
96triglyceride homeostasis (GO:0070328)3.88996968
97acylglycerol homeostasis (GO:0055090)3.88996968
98bile acid metabolic process (GO:0008206)3.88743980
99coenzyme catabolic process (GO:0009109)3.88376459
100negative regulation of potassium ion transmembrane transport (GO:1901380)3.87583276
101plasma membrane repair (GO:0001778)3.87459231
102fructose metabolic process (GO:0006000)3.87383327
103aromatic amino acid family metabolic process (GO:0009072)3.87311360
104regulation of fibrinolysis (GO:0051917)3.87112823
105branched-chain amino acid metabolic process (GO:0009081)3.86118578
106skeletal muscle tissue development (GO:0007519)3.85716797
107cellular glucan metabolic process (GO:0006073)3.85149284
108glucan metabolic process (GO:0044042)3.85149284
109regulation of fatty acid oxidation (GO:0046320)3.81689209
110positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.81605138
111positive regulation of fatty acid beta-oxidation (GO:0032000)3.81191471
112organic acid catabolic process (GO:0016054)3.80841628
113carboxylic acid catabolic process (GO:0046395)3.80841628
114dicarboxylic acid biosynthetic process (GO:0043650)3.76880246
115carnitine transmembrane transport (GO:1902603)3.73195609
116regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.72623434
117muscle tissue morphogenesis (GO:0060415)3.70300965
118succinate metabolic process (GO:0006105)3.67867272
119cardiac muscle tissue morphogenesis (GO:0055008)3.67551581
120regulation of striated muscle contraction (GO:0006942)3.66664743
121tyrosine metabolic process (GO:0006570)3.65347487
122skeletal muscle tissue regeneration (GO:0043403)3.64205630
123regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.64087868
124regulation of complement activation (GO:0030449)3.63752067
125NADH metabolic process (GO:0006734)3.63419304
126positive regulation of fatty acid oxidation (GO:0046321)3.63242555
127negative regulation of fatty acid biosynthetic process (GO:0045717)3.63160820
128amino-acid betaine transport (GO:0015838)3.61907478
129carnitine transport (GO:0015879)3.61907478
130regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.60898394
131plasma lipoprotein particle clearance (GO:0034381)3.60797216
132positive regulation of myotube differentiation (GO:0010831)3.60723597
133tricarboxylic acid metabolic process (GO:0072350)3.60248137
134cardiac muscle hypertrophy in response to stress (GO:0014898)3.59887856
135muscle hypertrophy in response to stress (GO:0003299)3.59887856
136cardiac muscle adaptation (GO:0014887)3.59887856
137glutamate metabolic process (GO:0006536)3.57950893
138muscle adaptation (GO:0043500)3.57372551
139positive regulation of lipid catabolic process (GO:0050996)3.56683903
140hexose biosynthetic process (GO:0019319)3.56409929
141adult heart development (GO:0007512)3.55067625
142cellular modified amino acid catabolic process (GO:0042219)3.54839998
143striated muscle atrophy (GO:0014891)3.52791258
144regulation of cholesterol esterification (GO:0010872)3.50065415
145protein-lipid complex remodeling (GO:0034368)3.48555685
146macromolecular complex remodeling (GO:0034367)3.48555685
147plasma lipoprotein particle remodeling (GO:0034369)3.48555685
148phospholipid homeostasis (GO:0055091)3.47492516
149oxaloacetate metabolic process (GO:0006107)3.47120491
150reverse cholesterol transport (GO:0043691)3.44416856
151glycine metabolic process (GO:0006544)3.44144961
152regulation of calcium ion transmembrane transport (GO:1903169)3.43348343
153regulation of calcium ion transmembrane transporter activity (GO:1901019)3.43348343
154muscle cell fate commitment (GO:0042693)3.40735082
155muscle cell cellular homeostasis (GO:0046716)3.38513000
156cellular response to epinephrine stimulus (GO:0071872)3.36568472
157response to epinephrine (GO:0071871)3.35575011
158benzene-containing compound metabolic process (GO:0042537)3.35216176
159response to activity (GO:0014823)3.33683702
160cellular glucuronidation (GO:0052695)3.30560068
161indolalkylamine metabolic process (GO:0006586)3.30382347
162regulation of acyl-CoA biosynthetic process (GO:0050812)3.28191527
163serine family amino acid metabolic process (GO:0009069)3.28057929
164regulation of fatty acid beta-oxidation (GO:0031998)3.27076829
165regulation of cholesterol metabolic process (GO:0090181)3.26487046
166phospholipid efflux (GO:0033700)3.26210239
167imidazole-containing compound metabolic process (GO:0052803)3.25548821
168negative regulation of lipase activity (GO:0060192)3.24735115
169negative regulation of cholesterol transport (GO:0032375)3.24714578
170regulation of the force of heart contraction (GO:0002026)3.21402955
171monosaccharide biosynthetic process (GO:0046364)3.21047169
172striated muscle cell development (GO:0055002)3.20427640
173positive regulation of cation channel activity (GO:2001259)3.19545208
174cellular carbohydrate catabolic process (GO:0044275)3.18979559
175negative regulation of necroptotic process (GO:0060546)3.17650020
176regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.15836117
177cardiac muscle cell development (GO:0055013)3.13991724
178muscle organ development (GO:0007517)3.11532551
179muscle structure development (GO:0061061)3.11246579
180negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.11230266
181negative regulation of calcium ion transmembrane transport (GO:1903170)3.11230266
182muscle organ morphogenesis (GO:0048644)3.07487623
183muscle atrophy (GO:0014889)3.07379338
184fatty acid homeostasis (GO:0055089)3.06034382
185response to mercury ion (GO:0046689)2.99699356
186negative regulation of muscle contraction (GO:0045932)2.98605222
187actin-myosin filament sliding (GO:0033275)10.9796617
188muscle filament sliding (GO:0030049)10.9796617

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.30554478
2RXR_22158963_ChIP-Seq_LIVER_Mouse7.03491473
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.20254831
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.53862283
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.02957134
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.58179071
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.75430908
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.70523211
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.63880215
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.68732423
11ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.35214727
12EZH2_22144423_ChIP-Seq_EOC_Human2.30494938
13VDR_21846776_ChIP-Seq_THP-1_Human2.29467451
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04863233
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.0981514
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.88893153
17CLOCK_20551151_ChIP-Seq_293T_Human1.83584517
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.72272514
19P68_20966046_ChIP-Seq_HELA_Human1.69841675
20KDM2B_26808549_Chip-Seq_DND41_Human1.68353108
21ZNF263_19887448_ChIP-Seq_K562_Human1.68056641
22TCF7_22412390_ChIP-Seq_EML_Mouse1.66652482
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.65592018
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.60203826
25KDM2B_26808549_Chip-Seq_SUP-B15_Human1.58396664
26ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.56230339
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.54675232
28CTCF_27219007_Chip-Seq_ERYTHROID_Human1.52198790
29GATA1_22025678_ChIP-Seq_K562_Human1.49067282
30NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.49029021
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.48262633
32FOXA2_19822575_ChIP-Seq_HepG2_Human1.47911609
33SA1_27219007_Chip-Seq_Bcells_Human1.43648127
34LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41492544
35SPI1_20517297_ChIP-Seq_HL60_Human1.40202190
36TBX20_22080862_ChIP-Seq_HEART_Mouse1.37340401
37TBX20_22328084_ChIP-Seq_HEART_Mouse1.37340401
38MYC_22102868_ChIP-Seq_BL_Human1.35606798
39MAF_26560356_Chip-Seq_TH1_Human1.33955109
40SA1_27219007_Chip-Seq_ERYTHROID_Human1.33800956
41SMC4_20622854_ChIP-Seq_HELA_Human1.32626956
42CTCF_26484167_Chip-Seq_Bcells_Mouse1.32625491
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31938339
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.29377442
45ELF1_20517297_ChIP-Seq_JURKAT_Human1.25384437
46TET1_21451524_ChIP-Seq_MESCs_Mouse1.22511633
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21205319
48STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.19954908
49YY1_22570637_ChIP-Seq_MALME-3M_Human1.18167386
50RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17987798
51HTT_18923047_ChIP-ChIP_STHdh_Human1.17395690
52MAF_26560356_Chip-Seq_TH2_Human1.17235894
53* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17031361
54HNF4A_19822575_ChIP-Seq_HepG2_Human1.15631564
55NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14965005
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12901916
57EP300_21415370_ChIP-Seq_HL-1_Mouse1.12862910
58PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.11993222
59VDR_24763502_ChIP-Seq_THP-1_Human1.11606300
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.11601965
61SMC3_22415368_ChIP-Seq_MEFs_Mouse1.09690770
62GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09419132
63EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07264488
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07173968
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05521513
66SCL_19346495_ChIP-Seq_HPC-7_Human1.05467116
67MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04834451
68CREB1_26743006_Chip-Seq_LNCaP_Human1.04448456
69PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04002253
70ETS1_21867929_ChIP-Seq_TH2_Mouse1.03719845
71BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02851593
72E2F1_20622854_ChIP-Seq_HELA_Human1.02533012
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01759384
74STAT1_20625510_ChIP-Seq_HELA_Human1.00542704
75IRF8_22096565_ChIP-ChIP_GC-B_Human1.00290984
76BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98953965
77* DROSHA_22980978_ChIP-Seq_HELA_Human0.95897820
78RARB_27405468_Chip-Seq_BRAIN_Mouse0.95797354
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95795488
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92304132
81OCT4_19829295_ChIP-Seq_ESCs_Human0.91758325
82AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88079793
83SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.86145649
84BP1_19119308_ChIP-ChIP_Hs578T_Human0.86134691
85STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.85542082
86SOX2_27498859_Chip-Seq_STOMACH_Mouse0.85279970
87RXRA_24833708_ChIP-Seq_LIVER_Mouse0.84885086
88PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84594889
89LXR_22292898_ChIP-Seq_THP-1_Human0.79179175
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.77804282
91EGR1_19032775_ChIP-ChIP_M12_Human0.76229109
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76089360
93ESR1_21235772_ChIP-Seq_MCF-7_Human0.74665453
94PPAR_26484153_Chip-Seq_NCI-H1993_Human0.73422866
95AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72252099
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.72114937
97GATA1_19941826_ChIP-Seq_K562_Human0.71566133
98STAT3_1855785_ChIP-Seq_MESCs_Mouse0.71103806
99BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70874194
100CEBPB_22108803_ChIP-Seq_LS180_Human0.70354779
101GATA1_19941827_ChIP-Seq_MEL_Mouse0.69111919
102NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.68635424
103NRF2_20460467_ChIP-Seq_MEFs_Mouse0.68635424
104RAD21_21589869_ChIP-Seq_MESCs_Mouse0.67715649
105TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67303922
106CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.66133846
107GATA4_25053715_ChIP-Seq_YYC3_Human0.66128775
108CTCF_27219007_Chip-Seq_Bcells_Human0.64906064
109CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.64756005
110TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.64550541
111BCAT_22108803_ChIP-Seq_LS180_Human0.63854629
112GATA2_19941826_ChIP-Seq_K562_Human0.63742663
113CDX2_19796622_ChIP-Seq_MESCs_Mouse0.62834901
114SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.62585244
115CBP_21632823_ChIP-Seq_H3396_Human0.61611185
116TAF2_19829295_ChIP-Seq_ESCs_Human0.60940867
117OCT4_20526341_ChIP-Seq_ESCs_Human0.60855437
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.60519513
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.60181305
120E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.59615036
121AR_20517297_ChIP-Seq_VCAP_Human0.59032962
122ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.58876828
123BCOR_27268052_Chip-Seq_Bcells_Human0.57896385
124GATA2_21666600_ChIP-Seq_HMVEC_Human0.57736944
125CTCF_21964334_ChIP-Seq_BJAB-B_Human0.56269456
126ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.55612546
127BCL6_27268052_Chip-Seq_Bcells_Human0.55102994
128CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.54870267
129GATA4_21415370_ChIP-Seq_HL-1_Mouse0.54055791
130PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.53078281
131RARA_24833708_ChIP-Seq_LIVER_Mouse0.52767170
132RACK7_27058665_Chip-Seq_MCF-7_Human0.52719419
133BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.52488309
134GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.52233090
135ERG_20517297_ChIP-Seq_VCAP_Human0.52137678
136EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.52086545
137DNAJC2_21179169_ChIP-ChIP_NT2_Human0.51908714
138ESET_19884257_ChIP-Seq_ESCs_Mouse0.51772131
139PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.51583091
140FOXH1_21741376_ChIP-Seq_ESCs_Human0.51474804
141FOXA1_25552417_ChIP-Seq_VCAP_Human0.50426007
142MYC_27129775_Chip-Seq_CORNEA_Mouse0.50015831
143NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.49985294
144FOXO3_23340844_ChIP-Seq_DLD1_Human0.49247023
145MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.49234168
146CTCF_21964334_Chip-Seq_Bcells_Human0.47999032
147P53_21459846_ChIP-Seq_SAOS-2_Human0.47842024

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.23434992
2MP0005360_urolithiasis5.63368764
3MP0005085_abnormal_gallbladder_physiolo5.08121153
4MP0005365_abnormal_bile_salt4.80029003
5MP0002837_dystrophic_cardiac_calcinosis3.89218186
6MP0003806_abnormal_nucleotide_metabolis3.82295785
7MP0008875_abnormal_xenobiotic_pharmacok3.65584835
8MP0003646_muscle_fatigue3.32355770
9MP0010329_abnormal_lipoprotein_level2.98513023
10MP0003252_abnormal_bile_duct2.91901447
11MP0004130_abnormal_muscle_cell2.63843691
12MP0005083_abnormal_biliary_tract2.55333903
13MP0000751_myopathy2.51844912
14MP0005332_abnormal_amino_acid2.51619415
15MP0003195_calcinosis2.46922130
16MP0009840_abnormal_foam_cell2.46581464
17MP0000749_muscle_degeneration2.22793807
18MP0006036_abnormal_mitochondrial_physio2.16474548
19MP0001666_abnormal_nutrient_absorption2.12260126
20MP0004036_abnormal_muscle_relaxation2.06924029
21MP0002118_abnormal_lipid_homeostasis2.03934237
22MP0005330_cardiomyopathy2.00942982
23MP0004084_abnormal_cardiac_muscle1.91099966
24MP0005670_abnormal_white_adipose1.87319481
25MP0003191_abnormal_cellular_cholesterol1.83281853
26MP0000609_abnormal_liver_physiology1.77811655
27MP0005319_abnormal_enzyme/_coenzyme1.77573648
28MP0004215_abnormal_myocardial_fiber1.74672778
29MP0004510_myositis1.70092593
30MP0005666_abnormal_adipose_tissue1.67308880
31MP0000733_abnormal_muscle_development1.67129756
32MP0004087_abnormal_muscle_fiber1.63626480
33MP0005584_abnormal_enzyme/coenzyme_acti1.59262855
34MP0002269_muscular_atrophy1.54705236
35MP0002971_abnormal_brown_adipose1.49255685
36MP0000747_muscle_weakness1.48873265
37MP0004145_abnormal_muscle_electrophysio1.47751937
38MP0003868_abnormal_feces_composition1.43020670
39MP0005451_abnormal_body_composition1.41319016
40MP0000013_abnormal_adipose_tissue1.41114946
41MP0005620_abnormal_muscle_contractility1.40246687
42MP0004019_abnormal_vitamin_homeostasis1.36472946
43MP0002106_abnormal_muscle_physiology1.34474244
44MP0002138_abnormal_hepatobiliary_system1.34441914
45MP0001764_abnormal_homeostasis1.27999505
46MP0002972_abnormal_cardiac_muscle1.25590536
47MP0006035_abnormal_mitochondrial_morpho1.19456345
48MP0001544_abnormal_cardiovascular_syste1.19055553
49MP0005385_cardiovascular_system_phenoty1.19055553
50MP0009643_abnormal_urine_homeostasis1.18956590
51MP0004185_abnormal_adipocyte_glucose1.16191549
52MP0000759_abnormal_skeletal_muscle1.14921039
53MP0005535_abnormal_body_temperature1.14189116
54MP0010630_abnormal_cardiac_muscle1.13397127
55MP0000750_abnormal_muscle_regeneration1.13309749
56MP0002078_abnormal_glucose_homeostasis1.13028032
57MP0006138_congestive_heart_failure1.13009598
58MP0008775_abnormal_heart_ventricle1.07610844
59MP0010368_abnormal_lymphatic_system1.06705859
60MP0002332_abnormal_exercise_endurance1.06705728
61MP0005369_muscle_phenotype1.06514526
62MP0003828_pulmonary_edema1.06143895
63MP0005266_abnormal_metabolism1.05630040
64MP0003221_abnormal_cardiomyocyte_apopto1.00687699
65MP0003656_abnormal_erythrocyte_physiolo1.00158793
66MP0003186_abnormal_redox_activity0.99816766
67MP0003705_abnormal_hypodermis_morpholog0.98621262
68MP0005334_abnormal_fat_pad0.98161317
69MP0003137_abnormal_impulse_conducting0.97618567
70MP0005375_adipose_tissue_phenotype0.97382941
71MP0009697_abnormal_copulation0.96514247
72MP0004484_altered_response_of0.89830954
73MP0004043_abnormal_pH_regulation0.88794157
74MP0000598_abnormal_liver_morphology0.86464416
75MP0003011_delayed_dark_adaptation0.83011926
76MP0005376_homeostasis/metabolism_phenot0.77804688
77MP0000230_abnormal_systemic_arterial0.77629156
78MP0005636_abnormal_mineral_homeostasis0.77317308
79MP0009642_abnormal_blood_homeostasis0.76912840
80MP0009763_increased_sensitivity_to0.75888147
81MP0004085_abnormal_heartbeat0.74784264
82MP0005448_abnormal_energy_balance0.72518875
83MP0003879_abnormal_hair_cell0.69609475
84MP0004270_analgesia0.68397171
85MP0004147_increased_porphyrin_level0.68120138
86MP0002822_catalepsy0.66926130
87MP0003045_fibrosis0.66134310
88MP0009764_decreased_sensitivity_to0.64473447
89MP0005647_abnormal_sex_gland0.64188674
90MP0008469_abnormal_protein_level0.63393031
91MP0000604_amyloidosis0.62712287
92MP0005167_abnormal_blood-brain_barrier0.62690386
93MP0000266_abnormal_heart_morphology0.60482646
94MP0001661_extended_life_span0.60343057
95MP0005084_abnormal_gallbladder_morpholo0.57875265
96MP0004233_abnormal_muscle_weight0.57062906
97MP0009115_abnormal_fat_cell0.56969399
98MP0002970_abnormal_white_adipose0.55829675
99MP0005452_abnormal_adipose_tissue0.53704332
100MP0003329_amyloid_beta_deposits0.53446721
101MP0000343_altered_response_to0.53339574
102MP0005165_increased_susceptibility_to0.53245693
103MP0002127_abnormal_cardiovascular_syste0.52792222
104MP0002638_abnormal_pupillary_reflex0.51286466
105MP0008874_decreased_physiological_sensi0.51264445
106MP0005058_abnormal_lysosome_morphology0.51180259
107MP0003953_abnormal_hormone_level0.51116815
108MP0001756_abnormal_urination0.51064016
109MP0000372_irregular_coat_pigmentation0.49023732
110MP0001853_heart_inflammation0.45819872
111MP0002876_abnormal_thyroid_physiology0.45357212
112MP0002108_abnormal_muscle_morphology0.44603426
113MP0000003_abnormal_adipose_tissue0.43769026
114MP0003959_abnormal_lean_body0.42607904
115MP0005166_decreased_susceptibility_to0.41597197
116MP0008004_abnormal_stomach_pH0.40912685
117MP0002128_abnormal_blood_circulation0.38648874
118MP0008569_lethality_at_weaning0.38480296
119MP0003948_abnormal_gas_homeostasis0.35721830
120MP0008260_abnormal_autophagy0.33642571
121MP0003950_abnormal_plasma_membrane0.31511334
122MP0001765_abnormal_ion_homeostasis0.31050178
123MP0002009_preneoplasia0.30326216
124MP0009780_abnormal_chondrocyte_physiolo0.29960732
125MP0003075_altered_response_to0.29955887
126MP0009278_abnormal_bone_marrow0.28507278
127MP0009672_abnormal_birth_weight0.25206294
128MP0002132_abnormal_respiratory_system0.24772554

Predicted human phenotypes

RankGene SetZ-score
1Myopathic facies (HP:0002058)5.57459438
2Distal arthrogryposis (HP:0005684)5.26946291
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.00849932
4Centrally nucleated skeletal muscle fibers (HP:0003687)4.88099780
5Intrahepatic cholestasis (HP:0001406)4.83970456
6Hypoglycemic coma (HP:0001325)4.71933010
7Deep venous thrombosis (HP:0002625)4.68311665
8Exercise-induced myalgia (HP:0003738)4.50507612
9Ketosis (HP:0001946)4.44671589
10Myoglobinuria (HP:0002913)4.40086704
11Hyperglycinuria (HP:0003108)4.39401721
12Neck muscle weakness (HP:0000467)4.38638946
13Round ear (HP:0100830)4.37709922
14Hyperammonemia (HP:0001987)4.36540587
15Xanthomatosis (HP:0000991)4.32833193
16Abnormality of skeletal muscle fiber size (HP:0012084)4.30409291
17Abnormality of fatty-acid metabolism (HP:0004359)4.26874441
18Rimmed vacuoles (HP:0003805)4.18431708
19Ketoacidosis (HP:0001993)4.10030980
20Ulnar deviation of the wrist (HP:0003049)4.04967245
21Abnormality of serine family amino acid metabolism (HP:0010894)4.02878063
22Abnormality of glycine metabolism (HP:0010895)4.02878063
23Abnormality of monocarboxylic acid metabolism (HP:0010996)3.98713886
24Hypobetalipoproteinemia (HP:0003563)3.93428944
25Hyperlipoproteinemia (HP:0010980)3.91790916
26Prolonged partial thromboplastin time (HP:0003645)3.91325256
27Hyperglycinemia (HP:0002154)3.87988299
28Dicarboxylic aciduria (HP:0003215)3.80949795
29Abnormality of dicarboxylic acid metabolism (HP:0010995)3.80949795
30Distal lower limb muscle weakness (HP:0009053)3.69452741
31Exercise-induced muscle cramps (HP:0003710)3.63250853
32Increased variability in muscle fiber diameter (HP:0003557)3.61542663
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.55856101
34Rhabdomyolysis (HP:0003201)3.54421815
35Bundle branch block (HP:0011710)3.50565301
36Hypoalphalipoproteinemia (HP:0003233)3.47658718
37Hypolipoproteinemia (HP:0010981)3.47082802
38Calcaneovalgus deformity (HP:0001848)3.41490146
39Calf muscle hypertrophy (HP:0008981)3.39911588
40Frequent falls (HP:0002359)3.37372452
41Muscle hypertrophy of the lower extremities (HP:0008968)3.35847204
42Complement deficiency (HP:0004431)3.35814634
43Areflexia of lower limbs (HP:0002522)3.35072057
44EMG: neuropathic changes (HP:0003445)3.23886509
45Sudden death (HP:0001699)3.23695717
46Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.21551461
47Cerebral edema (HP:0002181)3.20190143
48Hepatic necrosis (HP:0002605)3.19561622
49Muscle fiber inclusion bodies (HP:0100299)3.17517347
50Generalized aminoaciduria (HP:0002909)3.15656696
51Absent phalangeal crease (HP:0006109)3.03052114
52Epidermoid cyst (HP:0200040)2.98856794
53Abnormality of glutamine family amino acid metabolism (HP:0010902)2.97324302
54Deformed tarsal bones (HP:0008119)2.96191606
55Metabolic acidosis (HP:0001942)2.95529606
56Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.95275683
57Generalized muscle weakness (HP:0003324)2.95259108
58Hyporeflexia of lower limbs (HP:0002600)2.92695191
59Malignant hyperthermia (HP:0002047)2.90996809
60Joint hemorrhage (HP:0005261)2.90725524
61Abnormality of aspartate family amino acid metabolism (HP:0010899)2.87996790
62Lethargy (HP:0001254)2.84274333
63Muscle fiber splitting (HP:0003555)2.84038113
64Abnormality of serum amino acid levels (HP:0003112)2.81204419
65Progressive muscle weakness (HP:0003323)2.73909471
66Ventricular tachycardia (HP:0004756)2.72073680
67Bulbar palsy (HP:0001283)2.71296951
68Abnormality of the common coagulation pathway (HP:0010990)2.70071463
69Distal lower limb amyotrophy (HP:0008944)2.67724295
70Abnormality of sulfur amino acid metabolism (HP:0004339)2.66869195
71Abnormality of methionine metabolism (HP:0010901)2.66853877
72Nemaline bodies (HP:0003798)2.66401424
73Fat malabsorption (HP:0002630)2.60962914
74Muscle stiffness (HP:0003552)2.55201082
75Abnormality of the intrinsic pathway (HP:0010989)2.54616237
76Gout (HP:0001997)2.54309991
77Acute encephalopathy (HP:0006846)2.53187688
78Difficulty running (HP:0009046)2.50668616
79Cholelithiasis (HP:0001081)2.49315025
80Hyperinsulinemic hypoglycemia (HP:0000825)2.49179756
81Palpitations (HP:0001962)2.48789806
82Mildly elevated creatine phosphokinase (HP:0008180)2.48215532
83Asymmetric septal hypertrophy (HP:0001670)2.48042739
84Hyperbilirubinemia (HP:0002904)2.47593196
85Abnormal finger flexion creases (HP:0006143)2.46428607
86Delayed CNS myelination (HP:0002188)2.45934428
87Abnormal gallbladder morphology (HP:0012437)2.42248990
88Increased connective tissue (HP:0009025)2.40438307
89Abnormality of the calf musculature (HP:0001430)2.39585037
90Type 1 muscle fiber predominance (HP:0003803)2.39257510
91Vomiting (HP:0002013)2.38114523
92Abnormality of purine metabolism (HP:0004352)2.38050267
93Hepatocellular necrosis (HP:0001404)2.36918165
94Hypercholesterolemia (HP:0003124)2.36615795
95Renal cortical cysts (HP:0000803)2.33965979
96Skin nodule (HP:0200036)2.33351424
97EMG: myopathic abnormalities (HP:0003458)2.33128969
98Right ventricular cardiomyopathy (HP:0011663)2.31795589
99Abnormal atrioventricular conduction (HP:0005150)2.30885395
100Proximal tubulopathy (HP:0000114)2.30362916
101Weak cry (HP:0001612)2.29063890
102Abnormality of complement system (HP:0005339)2.27840979
103Lipoatrophy (HP:0100578)2.25249979
104* Increased muscle lipid content (HP:0009058)2.24728591
105Hyperkalemia (HP:0002153)2.24014166
106Hypoglycemic seizures (HP:0002173)2.23266171
107Abnormality of the foot musculature (HP:0001436)2.23163863
108Dilated cardiomyopathy (HP:0001644)2.21079125
109Atrioventricular block (HP:0001678)2.20482901
110Abnormality of nucleobase metabolism (HP:0010932)2.19309292
111Gowers sign (HP:0003391)2.18762977
112Late onset (HP:0003584)2.18252725
113Scapular winging (HP:0003691)2.17800424
114Ragged-red muscle fibers (HP:0003200)2.15404802
115* Lactic acidosis (HP:0003128)2.12331861
116Ventricular arrhythmia (HP:0004308)2.11444361
117Nausea (HP:0002018)2.10841721
118Conjugated hyperbilirubinemia (HP:0002908)2.09682260
119Difficulty climbing stairs (HP:0003551)2.09379162
120Fetal akinesia sequence (HP:0001989)2.07163519
121Foot dorsiflexor weakness (HP:0009027)2.06573360
122Abnormal mitochondria in muscle tissue (HP:0008316)2.05071476
123Hyperuricemia (HP:0002149)2.04365284
124Increased purine levels (HP:0004368)2.04365284
125Neonatal onset (HP:0003623)2.03203450
126Limb-girdle muscle atrophy (HP:0003797)2.00363863
127Hyperglycemia (HP:0003074)2.00325643
128Slender build (HP:0001533)2.00021041
129Ventricular fibrillation (HP:0001663)1.99296639
130Muscular dystrophy (HP:0003560)1.98591019
131Heart block (HP:0012722)1.98368523
132Abnormality of the left ventricular outflow tract (HP:0011103)1.95657805
133Subaortic stenosis (HP:0001682)1.95657805
134Oligomenorrhea (HP:0000876)1.94909516
135Abnormality of the calcaneus (HP:0008364)1.93455315
136Myotonia (HP:0002486)1.92917600
137Methylmalonic aciduria (HP:0012120)1.92793914
138Waddling gait (HP:0002515)1.92722277
139Abnormality of urine glucose concentration (HP:0011016)1.91486734
140Glycosuria (HP:0003076)1.91486734
141Atrial fibrillation (HP:0005110)1.90732434
142Fatigable weakness (HP:0003473)1.87016920
143Abnormality of the neuromuscular junction (HP:0003398)1.87016920
144Lower limb amyotrophy (HP:0007210)1.85691061
145Spinal rigidity (HP:0003306)1.83414604
146Paralysis (HP:0003470)1.83341948
147Proximal amyotrophy (HP:0007126)1.79961084
148* Exercise intolerance (HP:0003546)1.76035271
149Hip contracture (HP:0003273)1.75962860
150Facial diplegia (HP:0001349)1.71559974
151Respiratory insufficiency due to muscle weakness (HP:0002747)1.70287531
152Abnormality of the shoulder girdle musculature (HP:0001435)1.67470953
153Syncope (HP:0001279)1.54607661
154Metatarsus adductus (HP:0001840)1.50589395
155Nonprogressive disorder (HP:0003680)1.49312095
156Primary atrial arrhythmia (HP:0001692)1.43746939
157Cerebral palsy (HP:0100021)1.42292249
158Supraventricular tachycardia (HP:0004755)1.41551276
159Easy fatigability (HP:0003388)1.39360152
160Insulin-resistant diabetes mellitus (HP:0000831)1.38625096
161Long clavicles (HP:0000890)1.36448310
162Steppage gait (HP:0003376)1.36267086
163Dysmetric saccades (HP:0000641)1.35680058
164Supraventricular arrhythmia (HP:0005115)1.35597887
165Prolonged QT interval (HP:0001657)1.34390486
166Type 2 muscle fiber atrophy (HP:0003554)1.34073143
167Muscle fiber atrophy (HP:0100295)1.32801624

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.26139541
2OBSCN4.63721568
3TTN3.99479499
4TRIB33.13712159
5PDK43.02193947
6PDK33.02193947
7PHKG12.82690358
8PHKG22.82690358
9PKN22.79474290
10SIK12.53730962
11PINK12.39013724
12ERN12.27170086
13PIK3CG2.25696948
14INSRR2.21190259
15FGFR42.19468625
16TIE12.02227161
17EEF2K1.98900780
18MAP2K31.98111872
19PDK21.81457224
20MAP3K71.81105096
21MAP2K41.68894266
22LMTK21.61133969
23MYLK1.57533757
24PIK3CA1.56913422
25FLT31.56148273
26MUSK1.53232200
27MAPK121.27259243
28PRKAA21.26715363
29NEK11.18288052
30TRPM71.15285804
31PRPF4B1.11656884
32MAPK111.11244625
33MAP2K61.07075750
34TAOK31.07041557
35DMPK0.98821209
36MAP3K130.93468601
37CCNB10.93091367
38PRKAA10.92970321
39PTK60.88565622
40TGFBR20.85677908
41NEK90.85063661
42MST1R0.78286195
43EPHB10.75394429
44KDR0.74943190
45MAP3K30.74075152
46PRKD10.73383779
47RIPK10.73268232
48TYK20.71883901
49PDPK10.69705212
50MAP3K60.68751576
51KSR20.66402365
52CAMK1D0.65704079
53CAMK2G0.65394660
54ERBB40.63422508
55PKN10.62358999
56STK38L0.62075995
57NME10.62004940
58TNK20.61734701
59JAK20.61071904
60WNK40.60914100
61MAPK40.59586953
62PAK30.58457031
63PRKACG0.57948226
64PDK10.57430462
65GRK70.56223119
66CAMK2D0.55780232
67MAP3K50.55733464
68ABL20.55372612
69TBK10.54531746
70MAP3K110.53782893
71ZAP700.53403148
72JAK10.52838563
73MARK20.52014394
74TAOK20.51494609
75STK240.50286497
76MAPKAPK30.49278332
77MAP2K10.46021723
78MAPK70.45040417
79DAPK20.44439401
80RPS6KC10.44351972
81RPS6KL10.44351972
82MOS0.43118096
83CAMK40.42535531
84CAMK1G0.40596229
85RPS6KA60.40579543
86PRKG10.39960265
87RET0.39358777
88SMG10.37786478
89MAP3K10.37008591
90IRAK30.36540089
91SGK30.36071608
92PRKACA0.34989625
93PRKACB0.34411607
94MTOR0.32665474
95ICK0.32544607
96LATS10.31917525
97RPS6KA10.31598930
98ILK0.31231579
99RPS6KB20.30908702
100SGK10.30886136
101FGFR20.30185349
102TAOK10.29616134
103RPS6KB10.28751909
104CAMK10.28508778
105MAPK150.28300601
106RPS6KA30.28150661
107MARK30.28077524
108SGK20.27547323
109MAP4K10.27029238
110AKT20.26702428
111EPHA30.26645237
112LIMK10.26628738
113FES0.26298920
114RAF10.26274297
115AKT30.25897057
116CAMK2A0.25804131
117PRKCQ0.25668689
118MAPK100.25358493
119GSK3A0.24046062
120ROCK10.23537216
121CAMK2B0.23295830
122MAPK30.22978332
123SYK0.22934041
124STK380.22047467
125DYRK1B0.21342243
126PRKCZ0.21197637
127MET0.21043281
128PRKCH0.20603576
129MARK10.20516071
130DAPK30.20207709
131PDGFRA0.19999086
132KIT0.19827871
133FGFR30.19811250
134MAP2K20.18707072
135FRK0.18150830
136STK110.17992702
137HCK0.17448991
138ARAF0.17439365
139CDC42BPA0.16010096

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.47390906
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.44551841
3Fatty acid degradation_Homo sapiens_hsa000713.34365738
4Propanoate metabolism_Homo sapiens_hsa006403.26390319
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.17686648
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.92825131
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.91685239
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.90403417
9Nitrogen metabolism_Homo sapiens_hsa009102.79603337
10Arginine biosynthesis_Homo sapiens_hsa002202.57571215
11Fatty acid metabolism_Homo sapiens_hsa012122.54146718
12Tryptophan metabolism_Homo sapiens_hsa003802.52962097
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.51879126
14Butanoate metabolism_Homo sapiens_hsa006502.44534111
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.32045314
16PPAR signaling pathway_Homo sapiens_hsa033202.06130123
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.01228612
18Peroxisome_Homo sapiens_hsa041461.99797929
19Pyruvate metabolism_Homo sapiens_hsa006201.97001214
20Carbon metabolism_Homo sapiens_hsa012001.93475912
21Complement and coagulation cascades_Homo sapiens_hsa046101.89014606
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87421891
23beta-Alanine metabolism_Homo sapiens_hsa004101.79944298
24Fatty acid elongation_Homo sapiens_hsa000621.79835131
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.71201356
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58796571
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54471481
28Starch and sucrose metabolism_Homo sapiens_hsa005001.47587070
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.45222118
30Histidine metabolism_Homo sapiens_hsa003401.40047530
31Chemical carcinogenesis_Homo sapiens_hsa052041.39745373
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.36491396
33Phenylalanine metabolism_Homo sapiens_hsa003601.36317526
34Biosynthesis of amino acids_Homo sapiens_hsa012301.35610956
35Caffeine metabolism_Homo sapiens_hsa002321.29703458
36Oxytocin signaling pathway_Homo sapiens_hsa049211.26516271
37Retinol metabolism_Homo sapiens_hsa008301.20700282
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.20652815
39Tyrosine metabolism_Homo sapiens_hsa003501.20480924
40Bile secretion_Homo sapiens_hsa049761.20333433
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.19964747
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18335515
43Sulfur metabolism_Homo sapiens_hsa009201.16225888
44Fat digestion and absorption_Homo sapiens_hsa049751.10643751
45Selenocompound metabolism_Homo sapiens_hsa004501.10012408
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.06235675
47Staphylococcus aureus infection_Homo sapiens_hsa051501.05042611
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01994571
49Arginine and proline metabolism_Homo sapiens_hsa003300.96598774
50ABC transporters_Homo sapiens_hsa020100.95991614
51Folate biosynthesis_Homo sapiens_hsa007900.90909316
52Lysine degradation_Homo sapiens_hsa003100.90860712
53Other glycan degradation_Homo sapiens_hsa005110.89052499
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.88143325
55Fatty acid biosynthesis_Homo sapiens_hsa000610.86931476
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82585444
57Oxidative phosphorylation_Homo sapiens_hsa001900.81652113
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80354664
59Parkinsons disease_Homo sapiens_hsa050120.78713762
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78612498
61Glycerolipid metabolism_Homo sapiens_hsa005610.78287885
62Sulfur relay system_Homo sapiens_hsa041220.78190096
63Cardiac muscle contraction_Homo sapiens_hsa042600.76355258
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71945270
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.71505024
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70288484
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.68658307
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67300526
69Renin secretion_Homo sapiens_hsa049240.63740077
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.63437135
71Viral myocarditis_Homo sapiens_hsa054160.60184101
72Insulin resistance_Homo sapiens_hsa049310.60093340
73Alzheimers disease_Homo sapiens_hsa050100.57480801
74Pentose phosphate pathway_Homo sapiens_hsa000300.55586598
75GnRH signaling pathway_Homo sapiens_hsa049120.54746561
76Steroid biosynthesis_Homo sapiens_hsa001000.53815252
77Gastric acid secretion_Homo sapiens_hsa049710.53314956
78Metabolic pathways_Homo sapiens_hsa011000.52653777
79Vitamin B6 metabolism_Homo sapiens_hsa007500.52402942
80Glucagon signaling pathway_Homo sapiens_hsa049220.52052982
81Vitamin digestion and absorption_Homo sapiens_hsa049770.51943874
82Galactose metabolism_Homo sapiens_hsa000520.47412492
83Glutathione metabolism_Homo sapiens_hsa004800.46321930
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44332591
85FoxO signaling pathway_Homo sapiens_hsa040680.43779752
86Dilated cardiomyopathy_Homo sapiens_hsa054140.42330187
87mTOR signaling pathway_Homo sapiens_hsa041500.40885546
88Acute myeloid leukemia_Homo sapiens_hsa052210.39778367
89Fructose and mannose metabolism_Homo sapiens_hsa000510.39420723
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38450825
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38175739
92Long-term potentiation_Homo sapiens_hsa047200.38092380
93Platelet activation_Homo sapiens_hsa046110.36646233
94AMPK signaling pathway_Homo sapiens_hsa041520.35271940
95VEGF signaling pathway_Homo sapiens_hsa043700.33255887
96Insulin signaling pathway_Homo sapiens_hsa049100.32226211
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30352971
98Huntingtons disease_Homo sapiens_hsa050160.26941076
99Pancreatic secretion_Homo sapiens_hsa049720.25011974
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22488371
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20862398
102Insulin secretion_Homo sapiens_hsa049110.17473458
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16637659
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.16526440
105Non-small cell lung cancer_Homo sapiens_hsa052230.16443210
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.16369605
107MAPK signaling pathway_Homo sapiens_hsa040100.16104977
108HIF-1 signaling pathway_Homo sapiens_hsa040660.13022865
109Linoleic acid metabolism_Homo sapiens_hsa005910.12309931
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.11720888
111Purine metabolism_Homo sapiens_hsa002300.11626994
112Prion diseases_Homo sapiens_hsa050200.11533083
113Salivary secretion_Homo sapiens_hsa049700.09390136
114One carbon pool by folate_Homo sapiens_hsa006700.06771327
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.04945374
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.02021949
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.00614451
118Regulation of autophagy_Homo sapiens_hsa04140-0.1642504
119cGMP-PKG signaling pathway_Homo sapiens_hsa04022-0.1564169
120Calcium signaling pathway_Homo sapiens_hsa04020-0.1478068
121Type II diabetes mellitus_Homo sapiens_hsa04930-0.0706055
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261-0.0553034
123Circadian rhythm_Homo sapiens_hsa04710-0.0534473
124Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0383328
125Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0373248
126Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0345322

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