ADCK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)8.69571510
2cilium movement (GO:0003341)7.75485258
3motile cilium assembly (GO:0044458)7.66770017
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.98907646
5epithelial cilium movement (GO:0003351)6.81778296
6axoneme assembly (GO:0035082)5.76506321
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.37101764
8L-phenylalanine catabolic process (GO:0006559)5.37101764
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.11262139
10L-phenylalanine metabolic process (GO:0006558)5.11262139
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.08107527
12purine ribonucleotide transport (GO:0015868)4.97369348
13left/right pattern formation (GO:0060972)4.91450632
14amyloid precursor protein catabolic process (GO:0042987)4.80844563
15purine nucleotide transport (GO:0015865)4.52185832
16aromatic amino acid family catabolic process (GO:0009074)4.50377611
17alpha-linolenic acid metabolic process (GO:0036109)4.49421011
18reverse cholesterol transport (GO:0043691)4.44164312
19high-density lipoprotein particle remodeling (GO:0034375)4.36637489
20adenine nucleotide transport (GO:0051503)4.29317787
21glyoxylate metabolic process (GO:0046487)4.24303577
22phospholipid efflux (GO:0033700)4.22945579
23ventricular system development (GO:0021591)4.15955223
24cysteine metabolic process (GO:0006534)4.11991280
25tryptophan metabolic process (GO:0006568)4.06549872
26urea metabolic process (GO:0019627)3.98700475
27urea cycle (GO:0000050)3.98700475
28response to xenobiotic stimulus (GO:0009410)3.97553089
29peptidyl-glutamic acid carboxylation (GO:0017187)3.89002240
30protein carboxylation (GO:0018214)3.89002240
31sulfur amino acid catabolic process (GO:0000098)3.88571304
32regulation of triglyceride catabolic process (GO:0010896)3.87844976
33regulation of cholesterol esterification (GO:0010872)3.87420062
34tryptophan catabolic process (GO:0006569)3.83598872
35indole-containing compound catabolic process (GO:0042436)3.83598872
36indolalkylamine catabolic process (GO:0046218)3.83598872
37nucleotide transmembrane transport (GO:1901679)3.82503294
38regulation of cilium movement (GO:0003352)3.81615138
39negative regulation of fibrinolysis (GO:0051918)3.77672453
40regulation of fibrinolysis (GO:0051917)3.75644858
41plasma lipoprotein particle remodeling (GO:0034369)3.75510809
42protein-lipid complex remodeling (GO:0034368)3.75510809
43macromolecular complex remodeling (GO:0034367)3.75510809
44plasma lipoprotein particle clearance (GO:0034381)3.73060183
45intraciliary transport (GO:0042073)3.66951415
46cholesterol efflux (GO:0033344)3.66189845
47fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.65620730
48regulation of cholesterol homeostasis (GO:2000188)3.58779887
49bile acid biosynthetic process (GO:0006699)3.58718520
50microtubule bundle formation (GO:0001578)3.58193058
51positive regulation of triglyceride metabolic process (GO:0090208)3.57522181
52kynurenine metabolic process (GO:0070189)3.57351801
53negative regulation of cholesterol transport (GO:0032375)3.56751287
54negative regulation of sterol transport (GO:0032372)3.56751287
55nitrogen cycle metabolic process (GO:0071941)3.54716472
56negative regulation of immunoglobulin mediated immune response (GO:0002890)3.53632105
57negative regulation of B cell mediated immunity (GO:0002713)3.53632105
58amino-acid betaine metabolic process (GO:0006577)3.49333567
59regulation of cholesterol biosynthetic process (GO:0045540)3.45906099
60positive regulation of triglyceride biosynthetic process (GO:0010867)3.45844944
61plasma lipoprotein particle assembly (GO:0034377)3.45388393
62cilium organization (GO:0044782)3.41658600
63aromatic amino acid family metabolic process (GO:0009072)3.39471238
64tolerance induction (GO:0002507)3.39452355
65cilium assembly (GO:0042384)3.38783538
66iron-sulfur cluster assembly (GO:0016226)3.35492977
67metallo-sulfur cluster assembly (GO:0031163)3.35492977
68protein localization to cilium (GO:0061512)3.35395249
69negative regulation of lipase activity (GO:0060192)3.33622875
70homocysteine metabolic process (GO:0050667)3.32078184
71cellular modified amino acid catabolic process (GO:0042219)3.31502141
72positive regulation of triglyceride lipase activity (GO:0061365)3.31360803
73positive regulation of lipoprotein lipase activity (GO:0051006)3.31360803
74regulation of protein activation cascade (GO:2000257)3.29515183
75complement activation, alternative pathway (GO:0006957)3.29455206
76response to misfolded protein (GO:0051788)3.27880013
77base-excision repair, AP site formation (GO:0006285)3.26420316
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.25726172
79coenzyme catabolic process (GO:0009109)3.24731303
80left/right axis specification (GO:0070986)3.22361104
81low-density lipoprotein particle remodeling (GO:0034374)3.21754265
82triglyceride homeostasis (GO:0070328)3.21161505
83acylglycerol homeostasis (GO:0055090)3.21161505
84regulation of autophagic vacuole assembly (GO:2000785)3.21012623
85tyrosine metabolic process (GO:0006570)3.19222329
86protein-lipid complex assembly (GO:0065005)3.18978253
87peptidyl-arginine omega-N-methylation (GO:0035247)3.18682317
88bile acid metabolic process (GO:0008206)3.17671218
89serine family amino acid catabolic process (GO:0009071)3.17472033
90fructose metabolic process (GO:0006000)3.17368092
91lysine catabolic process (GO:0006554)3.17062599
92lysine metabolic process (GO:0006553)3.17062599
93positive regulation of lipid catabolic process (GO:0050996)3.16932608
94antigen processing and presentation of endogenous antigen (GO:0019883)3.15919003
95phospholipid homeostasis (GO:0055091)3.15330788
96vitamin transmembrane transport (GO:0035461)3.14857716
97regulation of triglyceride metabolic process (GO:0090207)3.13605164
98carnitine metabolic process (GO:0009437)3.11453311
99regulation of plasminogen activation (GO:0010755)3.11424757
100linoleic acid metabolic process (GO:0043651)3.10376619
101regulation of triglyceride biosynthetic process (GO:0010866)3.09791427
102regulation of cholesterol metabolic process (GO:0090181)3.09714101
103positive regulation of fatty acid biosynthetic process (GO:0045723)3.09560249
104plasma lipoprotein particle organization (GO:0071827)3.08417189
105alpha-amino acid catabolic process (GO:1901606)3.07844264
106positive regulation of steroid metabolic process (GO:0045940)3.07570397
107acute-phase response (GO:0006953)3.06062858
108indolalkylamine metabolic process (GO:0006586)3.04074367
109lipid oxidation (GO:0034440)3.02998458
110fatty-acyl-CoA biosynthetic process (GO:0046949)3.02725323
111cellular ketone body metabolic process (GO:0046950)3.02417343
112primary alcohol catabolic process (GO:0034310)3.02340654
113regulation of complement activation (GO:0030449)3.01921722
114hydrogen peroxide biosynthetic process (GO:0050665)3.01738434
115fatty acid oxidation (GO:0019395)3.01534105
116negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.00586745
117negative regulation of cell killing (GO:0031342)3.00586745
118positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.00558204
119positive regulation of fatty acid beta-oxidation (GO:0032000)3.00049817
120negative regulation of lymphocyte mediated immunity (GO:0002707)2.99866092
121ethanol metabolic process (GO:0006067)2.96473933
122protein-lipid complex subunit organization (GO:0071825)2.95467508
123amyloid precursor protein metabolic process (GO:0042982)2.95360779
124regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.95252537
125protein insertion into membrane (GO:0051205)2.94496812
126peptidyl-arginine N-methylation (GO:0035246)2.93488074
127peptidyl-arginine methylation (GO:0018216)2.93488074
128antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.93468193
129pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.91460232
130fibrinolysis (GO:0042730)2.90995352
131cellular amino acid catabolic process (GO:0009063)2.89661591
132glutathione biosynthetic process (GO:0006750)2.88432079
133fatty acid beta-oxidation (GO:0006635)2.87384059
134regulation of cilium assembly (GO:1902017)2.87247322
135short-chain fatty acid metabolic process (GO:0046459)2.86355319
136microtubule severing (GO:0051013)2.86154339
137lipoprotein metabolic process (GO:0042157)2.86031176
138nucleotide transport (GO:0006862)2.86003627
139dorsal/ventral neural tube patterning (GO:0021904)2.85999153
140cofactor catabolic process (GO:0051187)2.84177582
141cholesterol homeostasis (GO:0042632)2.83195203
142regulation of vacuole organization (GO:0044088)2.82468320
143fatty acid catabolic process (GO:0009062)2.82115042
144phosphatidylethanolamine metabolic process (GO:0046337)2.81389573
145pyrimidine nucleotide catabolic process (GO:0006244)2.80077917
146nucleoside transmembrane transport (GO:1901642)2.78911200
147sterol homeostasis (GO:0055092)2.77980010
148NAD biosynthetic process (GO:0009435)2.77026394
149phosphatidylethanolamine biosynthetic process (GO:0006646)2.75175043
150embryonic camera-type eye development (GO:0031076)2.73943232
151reactive oxygen species biosynthetic process (GO:1903409)2.73786127
152mannose metabolic process (GO:0006013)2.71534723
153antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.70123504
154pentose metabolic process (GO:0019321)2.65894874
155detection of bacterium (GO:0016045)2.64317225
156valine metabolic process (GO:0006573)2.64185582
157nonribosomal peptide biosynthetic process (GO:0019184)2.59699280
158mannosylation (GO:0097502)2.59106563
159GDP-mannose metabolic process (GO:0019673)2.58982368
160histone arginine methylation (GO:0034969)2.58166173
161regulation of interleukin-5 production (GO:0032674)2.55555086
162membrane protein intracellular domain proteolysis (GO:0031293)2.54736155
163positive regulation of histone deacetylation (GO:0031065)2.52868273
164GTP biosynthetic process (GO:0006183)2.52410348
165positive regulation by symbiont of host defense response (GO:0052509)2.52136831
166modulation by symbiont of host defense response (GO:0052031)2.52136831
167modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.52136831
168modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.52136831
169positive regulation by organism of defense response of other organism involved in symbiotic interact2.52136831
170modulation by symbiont of host immune response (GO:0052553)2.52136831
171positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.51805907
172opioid receptor signaling pathway (GO:0038003)2.51312644
173negative regulation of leukocyte mediated immunity (GO:0002704)2.49126222
174lytic vacuole organization (GO:0080171)2.47085342
175lysosome organization (GO:0007040)2.47085342
176NIK/NF-kappaB signaling (GO:0038061)2.46449550
177positive regulation of T cell mediated cytotoxicity (GO:0001916)2.45801286
178nucleoside diphosphate phosphorylation (GO:0006165)2.45462943
179negative regulation of glycoprotein biosynthetic process (GO:0010561)2.42002430
180detection of other organism (GO:0098543)2.40505877
181phosphatidylglycerol biosynthetic process (GO:0006655)2.39998452
182positive regulation of protein kinase C signaling (GO:0090037)2.39786533
183peptidyl-tyrosine autophosphorylation (GO:0038083)2.39190876
184cellular component assembly involved in morphogenesis (GO:0010927)2.39119207
185ethanol oxidation (GO:0006069)2.39080825
186regulation of microtubule-based movement (GO:0060632)2.38023823
187NADP metabolic process (GO:0006739)2.36906567
188negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.35084700
189pyrimidine-containing compound transmembrane transport (GO:0072531)2.34792046
190cell projection assembly (GO:0030031)2.33811148
191negative regulation of interleukin-6 production (GO:0032715)2.33514432
192UTP biosynthetic process (GO:0006228)2.33158378
193establishment of apical/basal cell polarity (GO:0035089)2.32591031
194regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.32246848
195establishment of mitochondrion localization (GO:0051654)2.32219127
196regulation of B cell apoptotic process (GO:0002902)2.30531330
197lung epithelium development (GO:0060428)2.30122066
198regulation of interleukin-13 production (GO:0032656)2.29910337
199axonemal dynein complex assembly (GO:0070286)10.6049103

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.91893344
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.72819820
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.89328059
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.44327117
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.36301176
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.34651958
7EGR1_23403033_ChIP-Seq_LIVER_Mouse4.27979540
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.17397699
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.84432666
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.23734811
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.90359358
12VDR_21846776_ChIP-Seq_THP-1_Human2.62934778
13* ELF1_20517297_ChIP-Seq_JURKAT_Human2.38080118
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.33771016
15* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.30821036
16GATA1_22025678_ChIP-Seq_K562_Human2.25528246
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05517601
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.98910559
19PHF8_20622854_ChIP-Seq_HELA_Human1.98082414
20SA1_27219007_Chip-Seq_ERYTHROID_Human1.91646197
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.89995511
22KDM2B_26808549_Chip-Seq_SUP-B15_Human1.87781098
23E2F1_20622854_ChIP-Seq_HELA_Human1.87593626
24* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.78840035
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74549560
26* YY1_22570637_ChIP-Seq_MALME-3M_Human1.71287380
27DROSHA_22980978_ChIP-Seq_HELA_Human1.68945463
28CLOCK_20551151_ChIP-Seq_293T_Human1.68402859
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.67958646
30EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.64123583
31CTCF_27219007_Chip-Seq_Bcells_Human1.61935542
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58789201
33RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.57784533
34SRY_22984422_ChIP-ChIP_TESTIS_Rat1.56838419
35CTCF_26484167_Chip-Seq_Bcells_Mouse1.49724736
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49625908
37* ELK3_25401928_ChIP-Seq_HUVEC_Human1.49032543
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.48890368
39* MAF_26560356_Chip-Seq_TH2_Human1.47364605
40* ERA_21632823_ChIP-Seq_H3396_Human1.47062135
41CTCF_27219007_Chip-Seq_ERYTHROID_Human1.47061882
42KDM2B_26808549_Chip-Seq_DND41_Human1.46154828
43IRF8_21731497_ChIP-ChIP_J774_Mouse1.45824132
44SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.43320044
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.42304770
46* MAF_26560356_Chip-Seq_TH1_Human1.42157481
47* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.42123227
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.40466678
49FOXP1_21924763_ChIP-Seq_HESCs_Human1.37945925
50CIITA_25753668_ChIP-Seq_RAJI_Human1.37398007
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37227950
52LXR_22292898_ChIP-Seq_THP-1_Human1.33509150
53VDR_24763502_ChIP-Seq_THP-1_Human1.31401613
54* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31187662
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30583542
56* CREB1_26743006_Chip-Seq_LNCaP_Human1.29170997
57* UTX_26944678_Chip-Seq_JUKART_Human1.28917682
58MYC_22102868_ChIP-Seq_BL_Human1.28073888
59RUNX1_22412390_ChIP-Seq_EML_Mouse1.26826066
60* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25934641
61CTCF_21964334_ChIP-Seq_BJAB-B_Human1.25652960
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24373601
63PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.23880166
64EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23873925
65CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22827847
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22634826
67JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.21049571
68TCF7_22412390_ChIP-Seq_EML_Mouse1.20633653
69CTCF_18555785_ChIP-Seq_MESCs_Mouse1.19426637
70ETS1_21867929_ChIP-Seq_TH2_Mouse1.19279739
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17944673
72Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.17229896
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17083165
74CTCF_21964334_Chip-Seq_Bcells_Human1.16648734
75SCL_19346495_ChIP-Seq_HPC-7_Human1.16457867
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16402541
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16375794
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15538224
79SPI1_20517297_ChIP-Seq_HL60_Human1.15184386
80ERG_21242973_ChIP-ChIP_JURKAT_Human1.14481147
81MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12558322
82* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12039111
83TRIM28_21343339_ChIP-Seq_HEK293_Human1.11733813
84* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.11302298
85IRF8_27001747_Chip-Seq_BMDM_Mouse1.10787460
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10362768
87SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10093331
88ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10023311
89* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10016873
90OCT4_19829295_ChIP-Seq_ESCs_Human1.09986056
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09955564
92STAT1_20625510_ChIP-Seq_HELA_Human1.08769198
93* RAC3_21632823_ChIP-Seq_H3396_Human1.07203399
94SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06515273
95* GABP_19822575_ChIP-Seq_HepG2_Human1.06345078
96OCT4_20526341_ChIP-Seq_ESCs_Human1.05083754
97RUNX1_27514584_Chip-Seq_MCF-7_Human1.04812827
98FOXA2_19822575_ChIP-Seq_HepG2_Human1.03219821
99CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02888414
100RAD21_21589869_ChIP-Seq_MESCs_Mouse1.02712950
101SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02247660
102IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01151835
103SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01009570
104GATA1_19941826_ChIP-Seq_K562_Human1.00636027
105CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99800927
106* GATA4_25053715_ChIP-Seq_YYC3_Human0.97248043
107IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.94998945
108BCOR_27268052_Chip-Seq_Bcells_Human0.94438182
109SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.94368540
110CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.94032556
111GATA1_19941827_ChIP-Seq_MEL_Mouse0.93847872
112PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91619567
113RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91133865
114LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89968339
115CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88915557
116SMC4_20622854_ChIP-Seq_HELA_Human0.88886187
117RXRA_24833708_ChIP-Seq_LIVER_Mouse0.87793135
118* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86415385
119RBPJ_22232070_ChIP-Seq_NCS_Mouse0.86041456
120E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.85083141
121BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.84340202
122* HNF4A_19822575_ChIP-Seq_HepG2_Human0.82196831
123TET1_21451524_ChIP-Seq_MESCs_Mouse0.80396575
124* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80323948
125EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.79929078
126* RARB_24833708_ChIP-Seq_LIVER_Mouse0.79694760
127CTCF_20526341_ChIP-Seq_ESCs_Human0.79190970
128SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79146376
129P63_26484246_Chip-Seq_KERATINOCYTES_Human0.78887376
130* TP63_22573176_ChIP-Seq_HFKS_Human0.78824810
131TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.77594620
132RACK7_27058665_Chip-Seq_MCF-7_Human0.76984319
133NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.75704254
134SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.74951649
135TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74068503
136SA1_27219007_Chip-Seq_Bcells_Human0.73131465
137TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.72866751
138NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.72136235
139GATA2_19941826_ChIP-Seq_K562_Human0.72091251
140CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71225941
141BCL6_27268052_Chip-Seq_Bcells_Human0.71107781
142ESR1_21235772_ChIP-Seq_MCF-7_Human0.70959704
143RARA_24833708_ChIP-Seq_LIVER_Mouse0.70185256
144SPI1_23127762_ChIP-Seq_K562_Human0.69415633
145TAF2_19829295_ChIP-Seq_ESCs_Human0.68934072
146PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.68603791
147AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68582864
148GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.68416164
149P300_27268052_Chip-Seq_Bcells_Human0.68228505
150STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.66757434
151PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.66326235
152JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.65895501
153ERG_20517297_ChIP-Seq_VCAP_Human0.65827265
154SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.64046639
155P68_20966046_ChIP-Seq_HELA_Human0.63915040
156SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63350872
157* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.63092279
158* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.62129952
159DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.60791586
160MYB_21317192_ChIP-Seq_ERMYB_Mouse0.60398156
161MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.59769001
162P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.58528970

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.56616560
2MP0005360_urolithiasis4.82681931
3MP0009840_abnormal_foam_cell4.71076749
4MP0005365_abnormal_bile_salt4.53126279
5MP0005085_abnormal_gallbladder_physiolo4.02191406
6MP0003878_abnormal_ear_physiology3.73955689
7MP0005377_hearing/vestibular/ear_phenot3.73955689
8MP0003191_abnormal_cellular_cholesterol3.32816847
9MP0010329_abnormal_lipoprotein_level3.17048512
10MP0008875_abnormal_xenobiotic_pharmacok3.14581995
11MP0003252_abnormal_bile_duct3.02786818
12MP0002138_abnormal_hepatobiliary_system2.91751144
13MP0004133_heterotaxia2.80278053
14MP0002249_abnormal_larynx_morphology2.64200766
15MP0005083_abnormal_biliary_tract2.47713197
16MP0005332_abnormal_amino_acid2.35084022
17MP0004019_abnormal_vitamin_homeostasis2.19264342
18MP0002118_abnormal_lipid_homeostasis2.17061291
19MP0005058_abnormal_lysosome_morphology2.15273912
20MP0009278_abnormal_bone_marrow2.13211064
21MP0003806_abnormal_nucleotide_metabolis2.05624909
22MP0001666_abnormal_nutrient_absorption2.04204988
23MP0002822_catalepsy1.99487045
24MP0005075_abnormal_melanosome_morpholog1.98240226
25MP0000609_abnormal_liver_physiology1.94670753
26MP0000604_amyloidosis1.91755242
27MP0003329_amyloid_beta_deposits1.81507867
28MP0002277_abnormal_respiratory_mucosa1.78268062
29MP0002102_abnormal_ear_morphology1.69784829
30MP0009643_abnormal_urine_homeostasis1.69348472
31MP0000678_abnormal_parathyroid_gland1.67759337
32MP0003011_delayed_dark_adaptation1.65364598
33MP0003195_calcinosis1.63943373
34MP0002254_reproductive_system_inflammat1.60563700
35MP0005584_abnormal_enzyme/coenzyme_acti1.60296113
36MP0005645_abnormal_hypothalamus_physiol1.59705718
37MP0003186_abnormal_redox_activity1.55969469
38MP0004782_abnormal_surfactant_physiolog1.55190536
39MP0009764_decreased_sensitivity_to1.55060999
40MP0003283_abnormal_digestive_organ1.54732340
41MP0003690_abnormal_glial_cell1.52784842
42MP0005319_abnormal_enzyme/_coenzyme1.48890174
43MP0010030_abnormal_orbit_morphology1.45296247
44MP0005670_abnormal_white_adipose1.45215192
45MP0002132_abnormal_respiratory_system1.43269308
46MP0005464_abnormal_platelet_physiology1.41746417
47MP0003075_altered_response_to1.39271433
48MP0001545_abnormal_hematopoietic_system1.33323770
49MP0005397_hematopoietic_system_phenotyp1.33323770
50MP0005671_abnormal_response_to1.31962897
51MP0008961_abnormal_basal_metabolism1.31838094
52MP0008260_abnormal_autophagy1.30181194
53MP0001800_abnormal_humoral_immune1.30136533
54MP0002723_abnormal_immune_serum1.27495545
55MP0002078_abnormal_glucose_homeostasis1.25035379
56MP0000685_abnormal_immune_system1.24956017
57MP0005379_endocrine/exocrine_gland_phen1.24877492
58MP0005220_abnormal_exocrine_pancreas1.24734603
59MP0008469_abnormal_protein_level1.24579265
60MP0002971_abnormal_brown_adipose1.21324727
61MP0003183_abnormal_peptide_metabolism1.20906339
62MP0000681_abnormal_thyroid_gland1.18048914
63MP0003436_decreased_susceptibility_to1.17731447
64MP0005000_abnormal_immune_tolerance1.16389139
65MP0001764_abnormal_homeostasis1.15225762
66MP0001944_abnormal_pancreas_morphology1.14929790
67MP0001849_ear_inflammation1.14741983
68MP0005084_abnormal_gallbladder_morpholo1.12299608
69MP0001819_abnormal_immune_cell1.11732475
70MP0002420_abnormal_adaptive_immunity1.10756205
71MP0003656_abnormal_erythrocyte_physiolo1.09303418
72MP0002405_respiratory_system_inflammati1.08720742
73MP0002876_abnormal_thyroid_physiology1.07418094
74MP0002928_abnormal_bile_duct1.06945278
75MP0005448_abnormal_energy_balance1.05167140
76MP0002452_abnormal_antigen_presenting1.04496996
77MP0001502_abnormal_circadian_rhythm1.04483490
78MP0005387_immune_system_phenotype1.03515922
79MP0001790_abnormal_immune_system1.03515922
80MP0001533_abnormal_skeleton_physiology1.03166376
81MP0009642_abnormal_blood_homeostasis1.02899018
82MP0010155_abnormal_intestine_physiology1.02183967
83MP0003172_abnormal_lysosome_physiology1.02146983
84MP0005636_abnormal_mineral_homeostasis1.02024937
85MP0002419_abnormal_innate_immunity1.01274022
86MP0003300_gastrointestinal_ulcer0.99836923
87MP0009765_abnormal_xenobiotic_induced0.98633988
88MP0005535_abnormal_body_temperature0.97236989
89MP0002693_abnormal_pancreas_physiology0.97056450
90MP0005248_abnormal_Harderian_gland0.96735883
91MP0009763_increased_sensitivity_to0.96697707
92MP0003303_peritoneal_inflammation0.96205701
93MP0005451_abnormal_body_composition0.95807033
94MP0004858_abnormal_nervous_system0.95575735
95MP0001873_stomach_inflammation0.95281448
96MP0002089_abnormal_postnatal_growth/wei0.94424288
97MP0000015_abnormal_ear_pigmentation0.93724245
98MP0000566_synostosis0.93265847
99MP0000598_abnormal_liver_morphology0.91883033
100MP0006082_CNS_inflammation0.89646942
101MP0001243_abnormal_dermal_layer0.89221859
102MP0005334_abnormal_fat_pad0.88693029
103MP0002168_other_aberrant_phenotype0.88334011
104MP0003705_abnormal_hypodermis_morpholog0.86947021
105MP0000026_abnormal_inner_ear0.84380660
106MP0005253_abnormal_eye_physiology0.83836851
107MP0002136_abnormal_kidney_physiology0.83610328
108MP0005310_abnormal_salivary_gland0.82214945
109MP0005408_hypopigmentation0.81870581
110MP0003866_abnormal_defecation0.81261379
111MP0009785_altered_susceptibility_to0.81246920
112MP0000465_gastrointestinal_hemorrhage0.81148213
113MP0000716_abnormal_immune_system0.80675703
114MP0003763_abnormal_thymus_physiology0.79590437
115MP0006035_abnormal_mitochondrial_morpho0.79501756
116MP0001845_abnormal_inflammatory_respons0.78337841
117MP0005025_abnormal_response_to0.78024846
118MP0003938_abnormal_ear_development0.77842920
119MP0001756_abnormal_urination0.77838519
120MP0008789_abnormal_olfactory_epithelium0.77797713
121MP0000013_abnormal_adipose_tissue0.77782351
122MP0002909_abnormal_adrenal_gland0.77596203
123MP0006036_abnormal_mitochondrial_physio0.77196282
124MP0004381_abnormal_hair_follicle0.76638273
125MP0000049_abnormal_middle_ear0.76403475
126MP0003953_abnormal_hormone_level0.76312688
127MP0003724_increased_susceptibility_to0.75660732
128MP0001270_distended_abdomen0.75657983
129MP0000470_abnormal_stomach_morphology0.73204309
130MP0009384_cardiac_valve_regurgitation0.71302634
131MP0005394_taste/olfaction_phenotype0.71288963
132MP0005499_abnormal_olfactory_system0.71288963
133MP0000579_abnormal_nail_morphology0.70604850
134MP0003698_abnormal_male_reproductive0.70438818
135MP0004947_skin_inflammation0.68553640
136MP0006072_abnormal_retinal_apoptosis0.66576477
137MP0002295_abnormal_pulmonary_circulatio0.66507911
138MP0001835_abnormal_antigen_presentation0.66190936
139MP0002148_abnormal_hypersensitivity_rea0.65676965
140MP0002429_abnormal_blood_cell0.65415467
141MP0000689_abnormal_spleen_morphology0.64889231
142MP0006292_abnormal_olfactory_placode0.64131780
143MP0005166_decreased_susceptibility_to0.63345160
144MP0005390_skeleton_phenotype0.62841411
145MP0004043_abnormal_pH_regulation0.62564258
146MP0005666_abnormal_adipose_tissue0.61579621
147MP0001984_abnormal_olfaction0.61510789
148MP0005646_abnormal_pituitary_gland0.60988638
149MP0002653_abnormal_ependyma_morphology0.60934077
150MP0001986_abnormal_taste_sensitivity0.60897250
151MP0002398_abnormal_bone_marrow0.60686967
152MP0002722_abnormal_immune_system0.60418977
153MP0002638_abnormal_pupillary_reflex0.60329295
154MP0001853_heart_inflammation0.60058144
155MP0002932_abnormal_joint_morphology0.60010605
156MP0010368_abnormal_lymphatic_system0.59643345
157MP0001765_abnormal_ion_homeostasis0.59592850
158MP0003868_abnormal_feces_composition0.59218186
159MP0009115_abnormal_fat_cell0.58817745

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.22045161
2Abnormal respiratory motile cilium morphology (HP:0005938)8.08480649
3Abnormal respiratory epithelium morphology (HP:0012253)8.08480649
4Absent/shortened dynein arms (HP:0200106)7.27809614
5Dynein arm defect of respiratory motile cilia (HP:0012255)7.27809614
6Abnormality of aromatic amino acid family metabolism (HP:0004338)5.53155655
7Prolonged partial thromboplastin time (HP:0003645)5.25567489
8Bronchiectasis (HP:0002110)5.09525132
9Chronic bronchitis (HP:0004469)4.98009954
10Xanthomatosis (HP:0000991)4.86096834
11Deep venous thrombosis (HP:0002625)4.58780646
12Intrahepatic cholestasis (HP:0001406)4.27251228
13Abnormality of monocarboxylic acid metabolism (HP:0010996)4.23979715
14Hyperlipoproteinemia (HP:0010980)4.01795295
15Joint hemorrhage (HP:0005261)3.88229004
16Recurrent sinusitis (HP:0011108)3.81892286
17Hypoglycemic coma (HP:0001325)3.77640677
18Hypoglycemic seizures (HP:0002173)3.75496207
19Ketosis (HP:0001946)3.72813153
20Occipital encephalocele (HP:0002085)3.71263572
21Hyperglycinuria (HP:0003108)3.63231494
22Chronic sinusitis (HP:0011109)3.55298039
23Abnormality of the intrinsic pathway (HP:0010989)3.39347633
24Hyperammonemia (HP:0001987)3.37668462
25Complement deficiency (HP:0004431)3.29608417
26Abnormality of serine family amino acid metabolism (HP:0010894)3.26887337
27Abnormality of glycine metabolism (HP:0010895)3.26887337
28Hypobetalipoproteinemia (HP:0003563)3.19656482
29Abnormality of glutamine family amino acid metabolism (HP:0010902)3.17413266
30Pancreatic fibrosis (HP:0100732)3.17061689
31Abnormality of the common coagulation pathway (HP:0010990)3.15613361
32Symptomatic seizures (HP:0011145)3.15211301
33Atelectasis (HP:0100750)3.12991546
34Hypoalphalipoproteinemia (HP:0003233)3.11022125
35Recurrent otitis media (HP:0000403)3.09788280
36Neurofibrillary tangles (HP:0002185)3.07525188
37Epidermoid cyst (HP:0200040)3.06821205
38True hermaphroditism (HP:0010459)3.03955619
39Ketoacidosis (HP:0001993)3.00824060
40Bronchitis (HP:0012387)2.99090664
41Broad distal phalanx of finger (HP:0009836)2.95204369
42Hypolipoproteinemia (HP:0010981)2.93103412
43Cystic liver disease (HP:0006706)2.91168910
44Flat capital femoral epiphysis (HP:0003370)2.87381838
45Stridor (HP:0010307)2.84070625
46Dysostosis multiplex (HP:0000943)2.82114261
47Abnormality of sulfur amino acid metabolism (HP:0004339)2.80336035
48Chronic otitis media (HP:0000389)2.78662514
49Gout (HP:0001997)2.75481561
50Abnormality of fatty-acid metabolism (HP:0004359)2.74749131
51Hyperglycinemia (HP:0002154)2.74424648
52Recurrent gram-negative bacterial infections (HP:0005420)2.73769645
53Nephronophthisis (HP:0000090)2.71269313
54Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.67761395
55Pancreatic cysts (HP:0001737)2.64687235
56Infertility (HP:0000789)2.63154971
57Generalized aminoaciduria (HP:0002909)2.60124858
58Molar tooth sign on MRI (HP:0002419)2.58397136
59Abnormality of midbrain morphology (HP:0002418)2.58397136
60Systemic lupus erythematosus (HP:0002725)2.56574591
61Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.50219260
62Abnormality of dicarboxylic acid metabolism (HP:0010995)2.49747513
63Dicarboxylic aciduria (HP:0003215)2.49747513
64Chronic hepatic failure (HP:0100626)2.47765803
65Recurrent bacterial skin infections (HP:0005406)2.45005437
66Recurrent abscess formation (HP:0002722)2.44373488
67Amyloidosis (HP:0011034)2.43401245
68Fat malabsorption (HP:0002630)2.39983578
69Late onset (HP:0003584)2.38876657
70Abnormality of methionine metabolism (HP:0010901)2.37835757
71Postaxial foot polydactyly (HP:0001830)2.37305730
72Vacuolated lymphocytes (HP:0001922)2.36073544
73Hand muscle atrophy (HP:0009130)2.35907422
74Abnormality of aspartate family amino acid metabolism (HP:0010899)2.34384226
75Abnormality of complement system (HP:0005339)2.31303114
76Autoimmune thrombocytopenia (HP:0001973)2.30295774
77Abnormal ciliary motility (HP:0012262)2.28313305
78Retinal atrophy (HP:0001105)2.28004163
79Irritability (HP:0000737)2.27226525
80Eczematoid dermatitis (HP:0000976)2.24941069
81Hypercholesterolemia (HP:0003124)2.23773487
82Opisthotonus (HP:0002179)2.23610762
83Interstitial pulmonary disease (HP:0006530)2.19745958
84Nasal polyposis (HP:0100582)2.18748594
85Back pain (HP:0003418)2.18363802
86Thoracic kyphosis (HP:0002942)2.16355229
87Abnormality of purine metabolism (HP:0004352)2.15780738
88Male infertility (HP:0003251)2.15141715
89Glomerulonephritis (HP:0000099)2.15076987
90Severe visual impairment (HP:0001141)2.12899048
91Neonatal hypoglycemia (HP:0001998)2.10827063
92Congenital hepatic fibrosis (HP:0002612)2.10577849
93Abnormality of glycolipid metabolism (HP:0010969)2.10251977
94Abnormality of liposaccharide metabolism (HP:0010968)2.10251977
95Abnormality of glycosphingolipid metabolism (HP:0004343)2.10251977
96Optic nerve coloboma (HP:0000588)2.10147959
97Myocardial infarction (HP:0001658)2.09605569
98Tubulointerstitial nephritis (HP:0001970)2.09298466
99Anencephaly (HP:0002323)2.09132605
100Gingival bleeding (HP:0000225)2.08411657
101Brushfield spots (HP:0001088)2.08406305
102Abnormal enzyme/coenzyme activity (HP:0012379)2.04910433
103Abnormality of proline metabolism (HP:0010907)2.04787831
104Hydroxyprolinuria (HP:0003080)2.04787831
105Elevated alkaline phosphatase (HP:0003155)2.04711273
106Rhinitis (HP:0012384)2.02411212
107Mucopolysacchariduria (HP:0008155)2.02284005
108Urinary glycosaminoglycan excretion (HP:0003541)2.02284005
109Vascular calcification (HP:0004934)2.02207191
110Hemorrhage of the eye (HP:0011885)2.02158729
111Abnormality of nucleobase metabolism (HP:0010932)2.01486766
112Alkalosis (HP:0001948)2.00771261
113Cerebral inclusion bodies (HP:0100314)2.00659205
114Abnormality of mucopolysaccharide metabolism (HP:0011020)1.99924983
115Abnormality of polysaccharide metabolism (HP:0011012)1.99924983
116Abnormality of glycosaminoglycan metabolism (HP:0004371)1.99924983
117Acanthocytosis (HP:0001927)1.99203328
118Sclerocornea (HP:0000647)1.98550812
119Upper limb amyotrophy (HP:0009129)1.98345216
120Distal upper limb amyotrophy (HP:0007149)1.98345216
121Hyperventilation (HP:0002883)1.97268422
122Metabolic acidosis (HP:0001942)1.96439520
123Enlarged kidneys (HP:0000105)1.96102137
124Abnormality of the aortic arch (HP:0012303)1.94889074
125Prolonged neonatal jaundice (HP:0006579)1.92746085
126Abnormality of alkaline phosphatase activity (HP:0004379)1.92739966
127Mitral stenosis (HP:0001718)1.90726842
128Myositis (HP:0100614)1.88446431
129Hyperinsulinemic hypoglycemia (HP:0000825)1.87953272
130Abnormal respiratory motile cilium physiology (HP:0012261)1.87084858
131Steatorrhea (HP:0002570)1.86973059
132Nephropathy (HP:0000112)1.86880856
133Respiratory distress (HP:0002098)1.86143359
134Abnormality of the renal medulla (HP:0100957)1.85966859
135Abnormality of the nasal mucosa (HP:0000433)1.85846158
136Progressive microcephaly (HP:0000253)1.85311605
137Increased cerebral lipofuscin (HP:0011813)1.84309829
138Increased neuronal autofluorescent lipopigment (HP:0002074)1.84180664
139Stomatitis (HP:0010280)1.83886574
140Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.83138106
141Protuberant abdomen (HP:0001538)1.82960679
142Hyperbilirubinemia (HP:0002904)1.82400326
143Spontaneous abortion (HP:0005268)1.82021823
144Pancreatitis (HP:0001733)1.81789967
145Abnormal biliary tract physiology (HP:0012439)1.79684528
146Bile duct proliferation (HP:0001408)1.79684528
147Congenital malformation of the right heart (HP:0011723)1.77793556
148Double outlet right ventricle (HP:0001719)1.77793556
149Retinal dysplasia (HP:0007973)1.77401564
150Aplasia/Hypoplasia of the spleen (HP:0010451)1.77175745
151Elevated erythrocyte sedimentation rate (HP:0003565)1.63373813
152Oculomotor apraxia (HP:0000657)1.63280944
153Recurrent bronchitis (HP:0002837)1.62333652
154Truncus arteriosus (HP:0001660)1.58939931
155Abnormal rod and cone electroretinograms (HP:0008323)1.57522674
156Asplenia (HP:0001746)1.57301061
157Medial flaring of the eyebrow (HP:0010747)1.56626323
158Preaxial hand polydactyly (HP:0001177)1.54692470
159Colitis (HP:0002583)1.54239268
160Agammaglobulinemia (HP:0004432)1.53836705
161Petechiae (HP:0000967)1.53569409
162Progressive neurologic deterioration (HP:0002344)1.48125407
163Gastrointestinal inflammation (HP:0004386)1.47882874
164Bell-shaped thorax (HP:0001591)1.47873091
165Orchitis (HP:0100796)1.47578895
166Hyperactive renin-angiotensin system (HP:0000841)1.46926919
167Absent rod-and cone-mediated responses on ERG (HP:0007688)1.45078062
168Growth hormone excess (HP:0000845)1.44519362
169Polyphagia (HP:0002591)1.42712900
170Postaxial hand polydactyly (HP:0001162)1.40722734
171Tetany (HP:0001281)1.40026545
172Renal salt wasting (HP:0000127)1.37754235
173Inflammation of the large intestine (HP:0002037)1.37725456
174Large for gestational age (HP:0001520)1.37702810
175Hypoplasia of the capital femoral epiphysis (HP:0003090)1.37466640
176Recurrent fungal infections (HP:0002841)1.37423909
177Flattened epiphyses (HP:0003071)1.37392746
178Male pseudohermaphroditism (HP:0000037)1.37113138
179Type I transferrin isoform profile (HP:0003642)1.37055660
180Ankle clonus (HP:0011448)1.36953851
181Loss of speech (HP:0002371)1.35155923
182Recurrent skin infections (HP:0001581)1.34807935
183Hypoplasia of the thymus (HP:0000778)1.34359047

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK14.33344499
2ERN14.15611262
3MAPK153.90370863
4BCKDK3.86075938
5EPHA33.31100099
6FGFR43.29056900
7TRIB32.91545239
8CAMK1D2.80721599
9MAP4K22.79088427
10SMG12.63344914
11CAMKK22.59048227
12TNK22.54520652
13INSRR2.36363378
14MAP3K142.11501469
15SIK32.03082793
16CDK191.97094619
17EPHB11.89182379
18PRKD21.82503920
19IRAK41.75377018
20CAMK1G1.64742354
21TYK21.55198323
22MAP3K11.54453644
23MAP3K31.53631924
24IRAK21.53258509
25MST1R1.47029244
26PIM21.43187730
27TAOK31.41528786
28SIK21.39474196
29TLK11.39080010
30EEF2K1.36769159
31DYRK1B1.35505624
32TBK11.33075555
33KDR1.29254478
34TESK11.27512353
35CSNK1G31.21880460
36FLT31.21271531
37MAP4K11.19726309
38MET1.15151802
39DYRK21.13079914
40JAK31.12575500
41PINK11.11439497
42TXK1.10983003
43SGK2231.08414646
44SGK4941.08414646
45NME11.08220799
46CAMKK11.08172827
47ZAK1.08150549
48LMTK21.06447810
49MAP3K71.06054003
50STK161.02475303
51CSNK1A1L1.02136954
52FES1.01714809
53PIK3CG1.00084601
54MARK20.95571045
55MAPKAPK30.94525743
56BLK0.94198429
57MAPK120.94101588
58TAOK10.91711109
59JAK10.89190474
60PTK60.88289059
61RPS6KA50.85451676
62MST40.84956768
63PAK30.84567086
64CSNK1G20.84509940
65CSNK1G10.84284016
66CDC42BPA0.83915332
67RAF10.83768610
68ARAF0.82859537
69GRK60.81986902
70JAK20.81390173
71PTK20.79885139
72MAP3K130.79360781
73PDPK10.78925330
74ITK0.78090021
75NTRK20.77746641
76BRD40.77268007
77CSF1R0.74826658
78BRAF0.74641451
79CHUK0.74509527
80RPS6KA20.73778652
81EPHA20.73750264
82ZAP700.71911609
83HCK0.71909148
84FRK0.71706731
85VRK20.71574426
86SGK30.70744635
87SGK20.70456620
88MAPK110.69876990
89ABL20.68458321
90MAPK130.67452152
91KSR20.66868403
92STK380.66057035
93MATK0.65318477
94BTK0.65082683
95TAOK20.64618617
96RPS6KC10.62829063
97RPS6KL10.62829063
98PDGFRA0.61400034
99PRKAA10.60625511
100IKBKB0.59822555
101PRKD30.57850427
102LYN0.57420367
103PRKCI0.56979051
104PKN20.56882267
105RPS6KA60.56119879
106PDK10.56058625
107PRKACG0.56018711
108DAPK20.55117219
109PTK2B0.55116791
110PKN10.54951375
111MAPK40.54471999
112NLK0.52146122
113IKBKE0.52000005
114HIPK20.51725668
115FGFR20.51666905
116IRAK30.51417934
117IRAK10.51193879
118PRKAA20.50985574
119LRRK20.50889680
120PRKCZ0.50772161
121ERBB40.49147077
122GRK10.49129420
123TGFBR20.49078797
124SYK0.49012401
125MAP3K110.47829629
126PRKCD0.47435884
127KIT0.45659149
128MAP2K20.44668890
129PRKCQ0.41694792
130PAK60.41575887
131MAP2K30.41508560
132RIPK40.41471937
133MAP3K100.41261732
134CAMK40.41174742
135BCR0.41161471
136MAP2K60.39890870
137TESK20.39857097
138MAP2K10.38096980
139NUAK10.38022877
140FER0.37846661
141TEC0.37275726
142MAP3K90.37019124
143GRK70.36658927
144ADRBK10.36243524
145MAPK70.36222862
146PRKCH0.35801553
147CSK0.35556564
148GSK3A0.35483428
149ADRBK20.34390998
150PASK0.34170047
151MAPKAPK20.33991961
152MARK30.32215720

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.61008008
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.04406509
3Fatty acid degradation_Homo sapiens_hsa000712.65189320
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.49956476
5Complement and coagulation cascades_Homo sapiens_hsa046102.42094944
6Nitrogen metabolism_Homo sapiens_hsa009102.37987220
7Tryptophan metabolism_Homo sapiens_hsa003802.37453960
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.34368543
9Peroxisome_Homo sapiens_hsa041462.21570237
10Fatty acid metabolism_Homo sapiens_hsa012122.21290341
11Butanoate metabolism_Homo sapiens_hsa006502.20636944
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.14016736
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.13020354
14Histidine metabolism_Homo sapiens_hsa003402.11887667
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.03533560
16PPAR signaling pathway_Homo sapiens_hsa033202.02669446
17Caffeine metabolism_Homo sapiens_hsa002322.01973939
18Arginine biosynthesis_Homo sapiens_hsa002201.99427456
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.99119788
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.97017396
21beta-Alanine metabolism_Homo sapiens_hsa004101.87414825
22Primary immunodeficiency_Homo sapiens_hsa053401.85700179
23Notch signaling pathway_Homo sapiens_hsa043301.83363462
24Staphylococcus aureus infection_Homo sapiens_hsa051501.83071208
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82139573
26Fatty acid elongation_Homo sapiens_hsa000621.75403779
27Propanoate metabolism_Homo sapiens_hsa006401.65920301
28Steroid biosynthesis_Homo sapiens_hsa001001.65508382
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.63565190
30Chemical carcinogenesis_Homo sapiens_hsa052041.49772363
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.49392970
32Allograft rejection_Homo sapiens_hsa053301.46848805
33Base excision repair_Homo sapiens_hsa034101.46026327
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.43866230
35Vitamin digestion and absorption_Homo sapiens_hsa049771.43140356
36Phenylalanine metabolism_Homo sapiens_hsa003601.38836840
37Folate biosynthesis_Homo sapiens_hsa007901.34728577
38Selenocompound metabolism_Homo sapiens_hsa004501.27713347
39Collecting duct acid secretion_Homo sapiens_hsa049661.22601155
40ABC transporters_Homo sapiens_hsa020101.21604714
41Systemic lupus erythematosus_Homo sapiens_hsa053221.19063452
42Autoimmune thyroid disease_Homo sapiens_hsa053201.18652412
43Fat digestion and absorption_Homo sapiens_hsa049751.18409366
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.18100646
45Lysosome_Homo sapiens_hsa041421.18077551
46Sulfur metabolism_Homo sapiens_hsa009201.17716731
47Pyruvate metabolism_Homo sapiens_hsa006201.16723135
48Bile secretion_Homo sapiens_hsa049761.16158260
49Osteoclast differentiation_Homo sapiens_hsa043801.10316750
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09723865
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09654704
52Vitamin B6 metabolism_Homo sapiens_hsa007501.09460813
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08813748
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04486929
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.02807759
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02092029
57Fatty acid biosynthesis_Homo sapiens_hsa000611.00383544
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99970873
59Alcoholism_Homo sapiens_hsa050340.99865342
60Graft-versus-host disease_Homo sapiens_hsa053320.98981137
61Starch and sucrose metabolism_Homo sapiens_hsa005000.98917002
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.98911328
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.96128891
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94769360
65Pentose phosphate pathway_Homo sapiens_hsa000300.94173059
66Retinol metabolism_Homo sapiens_hsa008300.92494620
67Tuberculosis_Homo sapiens_hsa051520.92277583
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90590211
69Tyrosine metabolism_Homo sapiens_hsa003500.88728099
70Biosynthesis of amino acids_Homo sapiens_hsa012300.87554835
71Acute myeloid leukemia_Homo sapiens_hsa052210.86723286
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.85290538
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84919805
74Carbon metabolism_Homo sapiens_hsa012000.84779269
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.84361313
76Protein export_Homo sapiens_hsa030600.82718507
77Glutathione metabolism_Homo sapiens_hsa004800.81921252
78B cell receptor signaling pathway_Homo sapiens_hsa046620.81227189
79Other glycan degradation_Homo sapiens_hsa005110.79576130
80Hepatitis C_Homo sapiens_hsa051600.79183665
81Fructose and mannose metabolism_Homo sapiens_hsa000510.79082331
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.75872340
83Vibrio cholerae infection_Homo sapiens_hsa051100.72921375
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72380078
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71398327
86Arginine and proline metabolism_Homo sapiens_hsa003300.70442272
87Prion diseases_Homo sapiens_hsa050200.70179069
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70020988
89Linoleic acid metabolism_Homo sapiens_hsa005910.69600932
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69066218
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68146291
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67502500
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66844827
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66554486
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65074985
96Lysine degradation_Homo sapiens_hsa003100.64890834
97Herpes simplex infection_Homo sapiens_hsa051680.63801509
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.62702850
99Phagosome_Homo sapiens_hsa041450.60332719
100Asthma_Homo sapiens_hsa053100.55277667
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54488096
102Antigen processing and presentation_Homo sapiens_hsa046120.54024742
103Insulin resistance_Homo sapiens_hsa049310.52537240
104AMPK signaling pathway_Homo sapiens_hsa041520.51618339
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50979139
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50807897
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50046954
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.49580513
109Glycerolipid metabolism_Homo sapiens_hsa005610.49213678
110Sulfur relay system_Homo sapiens_hsa041220.47862074
111Choline metabolism in cancer_Homo sapiens_hsa052310.47577478
112N-Glycan biosynthesis_Homo sapiens_hsa005100.47096364
113Toxoplasmosis_Homo sapiens_hsa051450.46384817
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46311581
115Metabolic pathways_Homo sapiens_hsa011000.43725843
116Regulation of autophagy_Homo sapiens_hsa041400.43441587
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42815045
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42059480
119Cyanoamino acid metabolism_Homo sapiens_hsa004600.41252981
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.41197818
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40207560
122Influenza A_Homo sapiens_hsa051640.37853683
123Type I diabetes mellitus_Homo sapiens_hsa049400.37267148
124Glucagon signaling pathway_Homo sapiens_hsa049220.36663632
125Galactose metabolism_Homo sapiens_hsa000520.36444169
126Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36130704
127Ovarian steroidogenesis_Homo sapiens_hsa049130.36031465
128Toll-like receptor signaling pathway_Homo sapiens_hsa046200.33471449
129Endocytosis_Homo sapiens_hsa041440.32484920
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31028471
131Circadian rhythm_Homo sapiens_hsa047100.30602350
132Ether lipid metabolism_Homo sapiens_hsa005650.27326623
133Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.24309529
134Sphingolipid metabolism_Homo sapiens_hsa006000.20161894
135Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.19166165
136Type II diabetes mellitus_Homo sapiens_hsa049300.16578178
137Arachidonic acid metabolism_Homo sapiens_hsa005900.16575448
138Malaria_Homo sapiens_hsa051440.13651081
139Pertussis_Homo sapiens_hsa051330.13090323
140Leishmaniasis_Homo sapiens_hsa051400.11200629
141Rheumatoid arthritis_Homo sapiens_hsa053230.10885979

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