ADCK5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline metabolic process (GO:0006560)8.80648891
2transcription from mitochondrial promoter (GO:0006390)7.96329993
3DNA deamination (GO:0045006)7.24284731
4replication fork processing (GO:0031297)6.95793753
5embryonic process involved in female pregnancy (GO:0060136)6.77311202
6positive regulation of protein homooligomerization (GO:0032464)6.41953006
7oxidative demethylation (GO:0070989)5.80338331
8maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.77535085
9regulation of protein homooligomerization (GO:0032462)5.68308430
10poly(A)+ mRNA export from nucleus (GO:0016973)5.49233081
11mitochondrial DNA metabolic process (GO:0032042)5.38326466
12somatic hypermutation of immunoglobulin genes (GO:0016446)5.31266260
13somatic diversification of immune receptors via somatic mutation (GO:0002566)5.31266260
14establishment of apical/basal cell polarity (GO:0035089)5.29021082
15regulation of integrin activation (GO:0033623)5.28585916
16glutamine family amino acid biosynthetic process (GO:0009084)5.00836512
17DNA strand renaturation (GO:0000733)5.00094066
18viral mRNA export from host cell nucleus (GO:0046784)4.90897575
19sulfur amino acid catabolic process (GO:0000098)4.81590511
20mannose metabolic process (GO:0006013)4.62804894
21establishment or maintenance of monopolar cell polarity (GO:0061339)4.52502777
22establishment of monopolar cell polarity (GO:0061162)4.52502777
23mitotic G1 DNA damage checkpoint (GO:0031571)4.48035380
24formation of translation preinitiation complex (GO:0001731)4.45187020
25GDP-mannose metabolic process (GO:0019673)4.40041056
26negative regulation of fatty acid biosynthetic process (GO:0045717)4.34450947
27negative regulation of cell cycle arrest (GO:0071157)4.29151928
28mRNA cleavage (GO:0006379)4.22244212
29embryonic placenta development (GO:0001892)4.07422909
30negative regulation of JAK-STAT cascade (GO:0046426)4.06645446
31telomere maintenance via semi-conservative replication (GO:0032201)4.05379966
32mitotic G1/S transition checkpoint (GO:0044819)4.05231718
33pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.04552331
34glutathione biosynthetic process (GO:0006750)3.99499790
35negative regulation of erythrocyte differentiation (GO:0045647)3.90731285
36G1 DNA damage checkpoint (GO:0044783)3.89951153
37base-excision repair (GO:0006284)3.89822670
38mitochondrial RNA metabolic process (GO:0000959)3.86502136
39regulation of translational fidelity (GO:0006450)3.84908990
40cellular response to ATP (GO:0071318)3.84277779
41DNA integration (GO:0015074)3.82623813
42cellular response to zinc ion (GO:0071294)3.79024854
43negative regulation of protein oligomerization (GO:0032460)3.75827844
44negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.74305206
45positive regulation of protein oligomerization (GO:0032461)3.68233446
46interferon-gamma secretion (GO:0072643)3.64509466
47base-excision repair, AP site formation (GO:0006285)3.63873205
48nonribosomal peptide biosynthetic process (GO:0019184)3.61820382
49Arp2/3 complex-mediated actin nucleation (GO:0034314)3.61723662
50very-low-density lipoprotein particle assembly (GO:0034379)3.61301512
51positive regulation of developmental pigmentation (GO:0048087)3.58697498
52establishment of protein localization to mitochondrial membrane (GO:0090151)3.56819872
53nucleotide-excision repair, DNA gap filling (GO:0006297)3.53204442
54DNA double-strand break processing (GO:0000729)3.51754937
55spliceosomal tri-snRNP complex assembly (GO:0000244)3.49544849
56intestinal cholesterol absorption (GO:0030299)3.49386024
57positive regulation of Cdc42 GTPase activity (GO:0043089)3.49374076
58regulation of protein oligomerization (GO:0032459)3.44162880
59positive regulation by host of viral transcription (GO:0043923)3.43923401
60pyrimidine nucleotide catabolic process (GO:0006244)3.39446595
61alkaloid metabolic process (GO:0009820)3.38516824
62double-strand break repair via nonhomologous end joining (GO:0006303)3.35549515
63non-recombinational repair (GO:0000726)3.35549515
64dosage compensation (GO:0007549)3.33739687
65regulation of double-strand break repair via homologous recombination (GO:0010569)3.29499530
66NIK/NF-kappaB signaling (GO:0038061)3.29075928
67activation of MAPKKK activity (GO:0000185)3.27408590
68face development (GO:0060324)3.26815946
69negative regulation of mRNA processing (GO:0050686)3.26566762
70mitochondrial DNA replication (GO:0006264)3.25699556
71termination of RNA polymerase II transcription (GO:0006369)3.25055715
72embryonic camera-type eye development (GO:0031076)3.21984805
73NADH metabolic process (GO:0006734)3.20861037
74DNA strand elongation involved in DNA replication (GO:0006271)3.17677346
75negative regulation of Ras GTPase activity (GO:0034261)3.16111403
76modulation by virus of host process (GO:0019054)3.16031469
77telomere maintenance via recombination (GO:0000722)3.15338154
78negative regulation of viral release from host cell (GO:1902187)3.14983690
79DNA topological change (GO:0006265)3.13621497
80meiotic chromosome segregation (GO:0045132)3.11584503
81trophectodermal cell differentiation (GO:0001829)3.10876683
82neutrophil activation involved in immune response (GO:0002283)3.07500301
83positive regulation of DNA repair (GO:0045739)3.06973689
84regulation of ARF GTPase activity (GO:0032312)3.06728001
85negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.06692663
86histone H4-K12 acetylation (GO:0043983)3.06192480
87negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.05987243
88modulation by symbiont of host cellular process (GO:0044068)3.03191828
89protein localization to endosome (GO:0036010)3.02274839
90convergent extension (GO:0060026)3.01832075
91negative regulation of RNA splicing (GO:0033119)3.01602597
92response to peptidoglycan (GO:0032494)3.00895335
93COPI coating of Golgi vesicle (GO:0048205)3.00530559
94Golgi transport vesicle coating (GO:0048200)3.00530559
95regulation of type I interferon-mediated signaling pathway (GO:0060338)2.99658124
96DNA ligation (GO:0006266)2.98246858
97maturation of 5.8S rRNA (GO:0000460)2.97719131
98DNA strand elongation (GO:0022616)2.97549189
99antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.96690334
100positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.89598788
101anatomical structure regression (GO:0060033)2.89076533
102antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.87268514
103positive regulation of circadian rhythm (GO:0042753)2.86514261
104urea cycle (GO:0000050)2.86112820
105response to muramyl dipeptide (GO:0032495)2.86051343
106antigen processing and presentation of endogenous antigen (GO:0019883)2.85667135
107regulation of DNA damage checkpoint (GO:2000001)2.85176813
108regulation of double-strand break repair (GO:2000779)2.84511433
109antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.84332567
110N-glycan processing (GO:0006491)2.80116852
111leukotriene metabolic process (GO:0006691)2.80021621
112glycosphingolipid catabolic process (GO:0046479)2.79488928
113DNA demethylation (GO:0080111)2.79308628
114glial cell migration (GO:0008347)2.78393579
115apoptotic process involved in morphogenesis (GO:0060561)2.78366534
116cullin deneddylation (GO:0010388)2.77527709
117kinetochore assembly (GO:0051382)2.76958561
118semaphorin-plexin signaling pathway (GO:0071526)2.76595673
119purine deoxyribonucleotide catabolic process (GO:0009155)2.76593794
120resolution of meiotic recombination intermediates (GO:0000712)2.76199714
121telomere maintenance via telomere lengthening (GO:0010833)2.76126526
122amino sugar catabolic process (GO:0046348)2.76013702
123regulation of viral release from host cell (GO:1902186)2.75911886
124positive regulation of gamma-delta T cell activation (GO:0046645)2.74007450
125protein retention in ER lumen (GO:0006621)2.73909181
126regulation of extracellular matrix disassembly (GO:0010715)2.73406589
127actin nucleation (GO:0045010)2.73106427
128nucleotide salvage (GO:0043173)2.71009968
129nodal signaling pathway (GO:0038092)2.70590639
130modulation by symbiont of host defense response (GO:0052031)2.68589129
131modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.68589129
132modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.68589129
133positive regulation by organism of defense response of other organism involved in symbiotic interact2.68589129
134modulation by symbiont of host immune response (GO:0052553)2.68589129
135positive regulation by symbiont of host defense response (GO:0052509)2.68589129
136thymic T cell selection (GO:0045061)2.68011763
137pentose metabolic process (GO:0019321)2.67956966
138positive regulation of receptor recycling (GO:0001921)2.66940001
139regulation of sister chromatid cohesion (GO:0007063)2.66861624
140immunoglobulin mediated immune response (GO:0016064)2.66329038
141negative regulation of tumor necrosis factor production (GO:0032720)2.66230706
142negative regulation of fatty acid metabolic process (GO:0045922)2.65594840
143regulation of mast cell degranulation (GO:0043304)2.65410542
144urea metabolic process (GO:0019627)2.64633346
145positive regulation of triglyceride lipase activity (GO:0061365)2.64306173
146positive regulation of lipoprotein lipase activity (GO:0051006)2.64306173
147regulation of early endosome to late endosome transport (GO:2000641)2.63777103
148mitotic nuclear envelope reassembly (GO:0007084)2.63026123
149nuclear envelope reassembly (GO:0031468)2.63026123
150negative regulation of cell size (GO:0045792)2.60766609
151regulation of interferon-beta biosynthetic process (GO:0045357)2.59559255
152entry into other organism involved in symbiotic interaction (GO:0051828)2.58801012
153movement in host environment (GO:0052126)2.58801012
154entry into host cell (GO:0030260)2.58801012
155movement in environment of other organism involved in symbiotic interaction (GO:0052192)2.58801012
156entry into cell of other organism involved in symbiotic interaction (GO:0051806)2.58801012
157entry into host (GO:0044409)2.58801012
158negative regulation of interleukin-2 production (GO:0032703)2.58373146
159glucose 6-phosphate metabolic process (GO:0051156)2.58296242
160retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.56363437
161regulation of leukocyte degranulation (GO:0043300)2.55886896
162myeloid dendritic cell differentiation (GO:0043011)2.55633695
163peptide biosynthetic process (GO:0043043)2.53469526
164germinal center formation (GO:0002467)2.52470643
165positive regulation of B cell differentiation (GO:0045579)2.52157879
166activation of Rac GTPase activity (GO:0032863)2.52155176
167leukotriene biosynthetic process (GO:0019370)2.52147894
168glycolipid catabolic process (GO:0019377)2.50405647
169negative regulation of cell killing (GO:0031342)2.50234182
170negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.50234182
171UV protection (GO:0009650)2.47994958
172detection of bacterium (GO:0016045)2.47943109
173regulation of defense response to virus by virus (GO:0050690)2.47900813
174regulation of myeloid leukocyte mediated immunity (GO:0002886)2.45268854
175cell-cell junction maintenance (GO:0045217)2.44488142
176nitrogen cycle metabolic process (GO:0071941)2.43032103
177lipopolysaccharide-mediated signaling pathway (GO:0031663)2.42802321
178positive thymic T cell selection (GO:0045059)2.42790659
179maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.41878227
180macrophage activation involved in immune response (GO:0002281)2.41433303
181viral entry into host cell (GO:0046718)2.39373833
182response to type I interferon (GO:0034340)2.37628631
183cellular response to type I interferon (GO:0071357)2.36061660
184type I interferon signaling pathway (GO:0060337)2.36061660
185peptidyl-arginine omega-N-methylation (GO:0035247)2.36016809
186oligosaccharide catabolic process (GO:0009313)2.35893477
187pinocytosis (GO:0006907)2.35517149
188positive regulation of keratinocyte differentiation (GO:0045618)2.34514460
189phosphatidylglycerol biosynthetic process (GO:0006655)2.34372956
190regulation of mammary gland epithelial cell proliferation (GO:0033599)2.34090132
191negative regulation of DNA-templated transcription, elongation (GO:0032785)2.32523886
192positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.32126077
193retrograde transport, endosome to Golgi (GO:0042147)2.32117158
194detection of other organism (GO:0098543)2.31985401
195proline biosynthetic process (GO:0006561)10.9897496

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.90743700
2MYC_18555785_ChIP-Seq_MESCs_Mouse2.85027125
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.77260690
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.68388348
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.68388348
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.68388348
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.60991237
8ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.55522753
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.53252121
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.49201758
11ELK3_25401928_ChIP-Seq_HUVEC_Human2.41028919
12VDR_21846776_ChIP-Seq_THP-1_Human2.28130221
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25980382
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.23297522
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.18323084
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.16463718
17E2F7_22180533_ChIP-Seq_HELA_Human2.11682173
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11470108
19KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.10044411
20RXR_22158963_ChIP-Seq_LIVER_Mouse2.07079722
21VDR_24763502_ChIP-Seq_THP-1_Human2.02942581
22SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.99930216
23* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.97822371
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.96868652
25NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.96056488
26KDM2B_26808549_Chip-Seq_DND41_Human1.90802257
27* P68_20966046_ChIP-Seq_HELA_Human1.89942378
28SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.89492727
29TCF7_22412390_ChIP-Seq_EML_Mouse1.86574778
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.85723713
31LXR_22292898_ChIP-Seq_THP-1_Human1.84141188
32STAT3_1855785_ChIP-Seq_MESCs_Mouse1.83327981
33NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.83145484
34CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.82232748
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.79763837
36POU5F1_16518401_ChIP-PET_MESCs_Mouse1.79248714
37* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.78992042
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.78643469
39PU.1_20513432_ChIP-Seq_Bcells_Mouse1.73115503
40MAF_26560356_Chip-Seq_TH1_Human1.72770711
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.72293052
42CTCF_27219007_Chip-Seq_ERYTHROID_Human1.71404386
43* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.71229115
44* BCOR_27268052_Chip-Seq_Bcells_Human1.67584156
45MAF_26560356_Chip-Seq_TH2_Human1.67326255
46TCF3_18692474_ChIP-Seq_MESCs_Mouse1.64896936
47* BCL6_27268052_Chip-Seq_Bcells_Human1.64851961
48ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.63710309
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.63640723
50* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63513129
51SA1_27219007_Chip-Seq_ERYTHROID_Human1.57231099
52TET1_21451524_ChIP-Seq_MESCs_Mouse1.57168536
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.55774203
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55669807
55ELF1_20517297_ChIP-Seq_JURKAT_Human1.54715014
56CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.54627492
57UTX_26944678_Chip-Seq_JUKART_Human1.53977360
58SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.53788331
59TCF3_18692474_ChIP-Seq_MEFs_Mouse1.53509331
60IRF8_22096565_ChIP-ChIP_GC-B_Human1.51179491
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51122736
62FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.49837538
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.49766584
64* RUNX1_22412390_ChIP-Seq_EML_Mouse1.48528762
65RXRA_24833708_ChIP-Seq_LIVER_Mouse1.47622111
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.46306412
67ETS1_20019798_ChIP-Seq_JURKAT_Human1.45504204
68NANOG_21062744_ChIP-ChIP_HESCs_Human1.43991219
69UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.42932921
70SMC4_20622854_ChIP-Seq_HELA_Human1.42786422
71MYC_22102868_ChIP-Seq_BL_Human1.42293176
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.42238646
73* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.41966335
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.41408914
75* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39141968
76FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.38680560
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38134623
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.37687988
79KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37685749
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.37009247
81SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35618597
82RARB_24833708_ChIP-Seq_LIVER_Mouse1.35583898
83RACK7_27058665_Chip-Seq_MCF-7_Human1.35273421
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34965430
85BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34458345
86GABP_19822575_ChIP-Seq_HepG2_Human1.34273212
87CREB1_26743006_Chip-Seq_LNCaP_Human1.33962514
88KDM2B_26808549_Chip-Seq_K562_Human1.33531650
89KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32867929
90RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32302006
91* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32257982
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31982509
93SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31294809
94NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.31189011
95POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.30351609
96NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.29337706
97* CTCF_26484167_Chip-Seq_Bcells_Mouse1.28829001
98DCP1A_22483619_ChIP-Seq_HELA_Human1.28622266
99* E2F1_20622854_ChIP-Seq_HELA_Human1.28545468
100NELFA_20434984_ChIP-Seq_ESCs_Mouse1.26915108
101ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25543265
102SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.24059490
103TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24005063
104NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22747292
105MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22538168
106POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21485013
107ZNF263_19887448_ChIP-Seq_K562_Human1.21469389
108NCOR1_26117541_ChIP-Seq_K562_Human1.20996759
109ETS1_21867929_ChIP-Seq_TH2_Mouse1.20987457
110SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20980271
111STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20760005
112TP63_17297297_ChIP-ChIP_HaCaT_Human1.20626241
113LXR_22158963_ChIP-Seq_LIVER_Mouse1.20352226
114CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20325491
115STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19973192
116RARA_24833708_ChIP-Seq_LIVER_Mouse1.19847756
117KDM2B_26808549_Chip-Seq_JURKAT_Human1.19713219
118OCT4_18692474_ChIP-Seq_MEFs_Mouse1.19700525
119SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19662789
120KDM5A_27292631_Chip-Seq_BREAST_Human1.19542349
121DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19381522
122STAT4_19710469_ChIP-ChIP_TH1__Mouse1.19358053
123ATF3_27146783_Chip-Seq_COLON_Human1.19179306
124CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17329277
125CTCF_27219007_Chip-Seq_Bcells_Human1.17261973
126SA1_27219007_Chip-Seq_Bcells_Human1.17217371
127NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17048809
128SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16990869
129CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16002215
130KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15432433
131SOX2_18692474_ChIP-Seq_MEFs_Mouse1.15146092
132SPI1_23127762_ChIP-Seq_K562_Human1.14449834
133XRN2_22483619_ChIP-Seq_HELA_Human1.14056324
134CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13359553
135SCL_19346495_ChIP-Seq_HPC-7_Human1.12839930
136HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.12413000
137ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12319306
138* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12028896
139KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11692243
140* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11055244
141EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10682516
142FOXM1_23109430_ChIP-Seq_U2OS_Human1.10646536
143CDX2_20551321_ChIP-Seq_CACO-2_Human1.09850168
144CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09669848
145SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09667003
146CTCF_21964334_Chip-Seq_Bcells_Human1.09398990
147TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09068593
148PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08336984
149TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07019195
150SPI1_26923725_Chip-Seq_HPCs_Mouse1.06614762
151GATA1_19941827_ChIP-Seq_MEL_Mouse1.06002890
152SOX2_18692474_ChIP-Seq_MESCs_Mouse1.05725984
153* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.05720408
154SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05699268
155TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05615891
156P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05461131
157NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.05113284
158MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04869943
159* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04215387
160CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04143167
161* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03834781
162SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03712015
163ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03285059
164NANOG_18692474_ChIP-Seq_MESCs_Mouse1.01080591
165ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00964114
166SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00443144
167* PHF8_20622854_ChIP-Seq_HELA_Human1.00382940
168SRF_21415370_ChIP-Seq_HL-1_Mouse0.99928871
169PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.99277964

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.32575782
2MP0009278_abnormal_bone_marrow3.67310579
3MP0010030_abnormal_orbit_morphology3.49751687
4MP0005451_abnormal_body_composition3.19030591
5MP0005171_absent_coat_pigmentation3.16871488
6MP0005085_abnormal_gallbladder_physiolo3.14017675
7MP0005365_abnormal_bile_salt3.08248504
8MP0002009_preneoplasia3.07861412
9MP0003436_decreased_susceptibility_to3.07062792
10MP0009840_abnormal_foam_cell2.96914977
11MP0008260_abnormal_autophagy2.61541211
12MP0004233_abnormal_muscle_weight2.54884343
13MP0003705_abnormal_hypodermis_morpholog2.53797310
14MP0005257_abnormal_intraocular_pressure2.51059797
15MP0003283_abnormal_digestive_organ2.45653347
16MP0008995_early_reproductive_senescence2.38792801
17MP0003191_abnormal_cellular_cholesterol2.36678829
18MP0003303_peritoneal_inflammation2.29795776
19MP0010094_abnormal_chromosome_stability2.21430531
20MP0003183_abnormal_peptide_metabolism2.11582313
21MP0005397_hematopoietic_system_phenotyp2.04397965
22MP0001545_abnormal_hematopoietic_system2.04397965
23MP0003890_abnormal_embryonic-extraembry2.04279228
24MP0004947_skin_inflammation2.03668692
25MP0010234_abnormal_vibrissa_follicle2.00627629
26MP0004957_abnormal_blastocyst_morpholog1.98066658
27MP0003806_abnormal_nucleotide_metabolis1.97178290
28MP0004264_abnormal_extraembryonic_tissu1.96938644
29MP0005174_abnormal_tail_pigmentation1.91356279
30MP0005360_urolithiasis1.89835906
31MP0008058_abnormal_DNA_repair1.89778509
32MP0002139_abnormal_hepatobiliary_system1.89752771
33MP0005025_abnormal_response_to1.86031447
34MP0003786_premature_aging1.85933475
35MP0005075_abnormal_melanosome_morpholog1.83317553
36MP0004133_heterotaxia1.82595008
37MP0002419_abnormal_innate_immunity1.80154678
38MP0010352_gastrointestinal_tract_polyps1.77225181
39MP0000858_altered_metastatic_potential1.76749872
40MP0005000_abnormal_immune_tolerance1.75906899
41MP0009785_altered_susceptibility_to1.75685125
42MP0000490_abnormal_crypts_of1.69586357
43MP0002249_abnormal_larynx_morphology1.67341613
44MP0002148_abnormal_hypersensitivity_rea1.63895758
45MP0003119_abnormal_digestive_system1.62894362
46MP0002653_abnormal_ependyma_morphology1.62336057
47MP0001835_abnormal_antigen_presentation1.59934841
48MP0003453_abnormal_keratinocyte_physiol1.57571769
49MP0001800_abnormal_humoral_immune1.52405599
50MP0003111_abnormal_nucleus_morphology1.50347350
51MP0000462_abnormal_digestive_system1.48869800
52MP0004019_abnormal_vitamin_homeostasis1.48163004
53MP0002723_abnormal_immune_serum1.47123557
54MP0002452_abnormal_antigen_presenting1.46366744
55MP0004510_myositis1.45674491
56MP0006072_abnormal_retinal_apoptosis1.43071272
57MP0002796_impaired_skin_barrier1.42682340
58MP0002933_joint_inflammation1.41422516
59MP0002420_abnormal_adaptive_immunity1.41247616
60MP0001819_abnormal_immune_cell1.41159907
61MP0002086_abnormal_extraembryonic_tissu1.39491919
62MP0000470_abnormal_stomach_morphology1.36857741
63MP0005464_abnormal_platelet_physiology1.36092792
64MP0001348_abnormal_lacrimal_gland1.35771097
65MP0008877_abnormal_DNA_methylation1.35021575
66MP0005058_abnormal_lysosome_morphology1.34859291
67MP0001533_abnormal_skeleton_physiology1.34640198
68MP0000371_diluted_coat_color1.34366950
69MP0001790_abnormal_immune_system1.33991510
70MP0005387_immune_system_phenotype1.33991510
71MP0000604_amyloidosis1.33525537
72MP0008875_abnormal_xenobiotic_pharmacok1.31524221
73MP0005671_abnormal_response_to1.31121551
74MP0003300_gastrointestinal_ulcer1.31032444
75MP0000639_abnormal_adrenal_gland1.30676457
76MP0003693_abnormal_embryo_hatching1.30106262
77MP0000579_abnormal_nail_morphology1.29831051
78MP0003718_maternal_effect1.29378793
79MP0001845_abnormal_inflammatory_respons1.29131075
80MP0002282_abnormal_trachea_morphology1.27954897
81MP0003329_amyloid_beta_deposits1.27915869
82MP0005310_abnormal_salivary_gland1.26877831
83MP0005409_darkened_coat_color1.26340530
84MP0005076_abnormal_cell_differentiation1.25015683
85MP0001849_ear_inflammation1.24217579
86MP0001293_anophthalmia1.24191895
87MP0003763_abnormal_thymus_physiology1.22966985
88MP0008932_abnormal_embryonic_tissue1.22822971
89MP0003172_abnormal_lysosome_physiology1.21218692
90MP0008469_abnormal_protein_level1.18656324
91MP0003656_abnormal_erythrocyte_physiolo1.15361088
92MP0000716_abnormal_immune_system1.15084532
93MP0001853_heart_inflammation1.14436994
94MP0001697_abnormal_embryo_size1.14193183
95MP0001663_abnormal_digestive_system1.13507424
96MP0002084_abnormal_developmental_patter1.12340609
97MP0000678_abnormal_parathyroid_gland1.12168831
98MP0001666_abnormal_nutrient_absorption1.11936701
99MP0003077_abnormal_cell_cycle1.11691191
100MP0003567_abnormal_fetal_cardiomyocyte1.11130634
101MP0002254_reproductive_system_inflammat1.10542181
102MP0004197_abnormal_fetal_growth/weight/1.09701576
103MP0000685_abnormal_immune_system1.09332484
104MP0003252_abnormal_bile_duct1.08591763
105MP0002998_abnormal_bone_remodeling1.08467146
106MP0002166_altered_tumor_susceptibility1.07962914
107MP0005501_abnormal_skin_physiology1.07810805
108MP0002085_abnormal_embryonic_tissue1.06324866
109MP0000015_abnormal_ear_pigmentation1.04274243
110MP0002111_abnormal_tail_morphology1.04019838
111MP0002398_abnormal_bone_marrow1.03882464
112MP0002019_abnormal_tumor_incidence1.02667693
113MP0004185_abnormal_adipocyte_glucose1.01405581
114MP0002429_abnormal_blood_cell1.00210490
115MP0003279_aneurysm1.00072572
116MP0005666_abnormal_adipose_tissue0.99808401
117MP0005266_abnormal_metabolism0.99398253
118MP0002269_muscular_atrophy0.98526584
119MP0005380_embryogenesis_phenotype0.97747988
120MP0001672_abnormal_embryogenesis/_devel0.97747988
121MP0003724_increased_susceptibility_to0.97435623
122MP0001764_abnormal_homeostasis0.96358515
123MP0001216_abnormal_epidermal_layer0.95720607
124MP0002089_abnormal_postnatal_growth/wei0.95456614
125MP0010155_abnormal_intestine_physiology0.95390391
126MP0002722_abnormal_immune_system0.95064388
127MP0003566_abnormal_cell_adhesion0.94810466
128MP0005023_abnormal_wound_healing0.93940022
129MP0005166_decreased_susceptibility_to0.93691095
130MP0009931_abnormal_skin_appearance0.92390833
131MP0000609_abnormal_liver_physiology0.92074339
132MP0000477_abnormal_intestine_morphology0.92050998
133MP0005375_adipose_tissue_phenotype0.91065323
134MP0000003_abnormal_adipose_tissue0.89882098
135MP0002060_abnormal_skin_morphology0.89474581
136MP0000689_abnormal_spleen_morphology0.89330084
137MP0005381_digestive/alimentary_phenotyp0.87936082
138MP0001873_stomach_inflammation0.87184404
139MP0002132_abnormal_respiratory_system0.87015688
140MP0000350_abnormal_cell_proliferation0.86178021
141MP0001324_abnormal_eye_pigmentation0.84733891
142MP0003866_abnormal_defecation0.84458677
143MP0000343_altered_response_to0.84101085
144MP0004858_abnormal_nervous_system0.83754634
145MP0002006_tumorigenesis0.81915565
146MP0009643_abnormal_urine_homeostasis0.81239527
147MP0005390_skeleton_phenotype0.80787775
148MP0009333_abnormal_splenocyte_physiolog0.80695885
149MP0005319_abnormal_enzyme/_coenzyme0.80659728
150MP0003075_altered_response_to0.80462743
151MP0002932_abnormal_joint_morphology0.79917120
152MP0002080_prenatal_lethality0.79827994
153MP0005220_abnormal_exocrine_pancreas0.79602816
154MP0001340_abnormal_eyelid_morphology0.79066353
155MP0005330_cardiomyopathy0.78086106
156MP0000762_abnormal_tongue_morphology0.78005648
157MP0005083_abnormal_biliary_tract0.77560935
158MP0001730_embryonic_growth_arrest0.77076109
159MP0003828_pulmonary_edema0.76351410
160MP0000467_abnormal_esophagus_morphology0.76246214
161MP0009053_abnormal_anal_canal0.76034627
162MP0005332_abnormal_amino_acid0.75528915
163MP0006082_CNS_inflammation0.75254397
164MP0002396_abnormal_hematopoietic_system0.74983449
165MP0005647_abnormal_sex_gland0.74551078
166MP0000751_myopathy0.74536457
167MP0001243_abnormal_dermal_layer0.74474729
168MP0002075_abnormal_coat/hair_pigmentati0.74329109
169MP0002405_respiratory_system_inflammati0.74261746
170MP0009384_cardiac_valve_regurgitation0.74108737
171MP0004381_abnormal_hair_follicle0.73362261
172MP0003984_embryonic_growth_retardation0.73061791
173MP0000313_abnormal_cell_death0.72082569
174MP0009115_abnormal_fat_cell0.71550324
175MP0010329_abnormal_lipoprotein_level0.71067731

Predicted human phenotypes

RankGene SetZ-score
1Pustule (HP:0200039)5.26827836
2Increased IgM level (HP:0003496)4.81083694
3Rib fusion (HP:0000902)4.76416786
4Hypochromic microcytic anemia (HP:0004840)4.73532061
5Poikiloderma (HP:0001029)4.58932176
6Concave nail (HP:0001598)4.49297866
7Alopecia of scalp (HP:0002293)4.46879499
8Rectovaginal fistula (HP:0000143)4.43770384
9Rectal fistula (HP:0100590)4.43770384
10Facial hemangioma (HP:0000329)4.24604152
11Annular pancreas (HP:0001734)4.18599939
12Vaginal fistula (HP:0004320)4.13358228
13Turricephaly (HP:0000262)4.03923806
14Intestinal fistula (HP:0100819)3.99969107
15Tongue fasciculations (HP:0001308)3.90415127
16Abnormal hemoglobin (HP:0011902)3.89154676
17Thin bony cortex (HP:0002753)3.79462648
18Ulnar bowing (HP:0003031)3.60727897
19Muscle fibrillation (HP:0010546)3.45207740
20Mucopolysacchariduria (HP:0008155)3.39516912
21Urinary glycosaminoglycan excretion (HP:0003541)3.39516912
22Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.38307795
23Short humerus (HP:0005792)3.37181117
24Abnormality of male internal genitalia (HP:0000022)3.35270322
25J-shaped sella turcica (HP:0002680)3.33637673
26Aplasia/hypoplasia of the humerus (HP:0006507)3.29087801
27Intestinal atresia (HP:0011100)3.28560156
28Orthostatic hypotension (HP:0001278)3.27861156
29Vertebral hypoplasia (HP:0008417)3.27329493
30Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.27329493
31Stridor (HP:0010307)3.22434800
32Eczematoid dermatitis (HP:0000976)3.20425528
33Abnormality of liposaccharide metabolism (HP:0010968)3.19477458
34Abnormality of glycosphingolipid metabolism (HP:0004343)3.19477458
35Abnormality of glycolipid metabolism (HP:0010969)3.19477458
36Coronal craniosynostosis (HP:0004440)3.19353925
37Abnormality of macrophages (HP:0004311)3.17323208
38Male infertility (HP:0003251)3.13555382
39Abnormality of mucopolysaccharide metabolism (HP:0011020)3.08858193
40Abnormality of polysaccharide metabolism (HP:0011012)3.08858193
41Abnormality of glycosaminoglycan metabolism (HP:0004371)3.08858193
42Colitis (HP:0002583)3.03719129
43Malnutrition (HP:0004395)3.03342271
44Hypobetalipoproteinemia (HP:0003563)2.98452906
45Pancreatic islet-cell hyperplasia (HP:0004510)2.97139640
46Absent radius (HP:0003974)2.94777830
47Hemorrhage of the eye (HP:0011885)2.92962706
48Squamous cell carcinoma (HP:0002860)2.90244784
49Cervical subluxation (HP:0003308)2.88842572
50Hypochromic anemia (HP:0001931)2.85634376
51Anteriorly placed anus (HP:0001545)2.80462914
52Absent thumb (HP:0009777)2.80363541
53Abnormality of the aortic arch (HP:0012303)2.79524251
54Systemic lupus erythematosus (HP:0002725)2.77599951
55Upper limb amyotrophy (HP:0009129)2.77116479
56Distal upper limb amyotrophy (HP:0007149)2.77116479
57Absent forearm bone (HP:0003953)2.73812853
58Aplasia involving forearm bones (HP:0009822)2.73812853
59Dysautonomia (HP:0002459)2.73305247
60Dysostosis multiplex (HP:0000943)2.72261258
61Increased cerebral lipofuscin (HP:0011813)2.70801702
62Premature skin wrinkling (HP:0100678)2.70450016
63Albinism (HP:0001022)2.66724102
64Alacrima (HP:0000522)2.66499481
65Bifid uvula (HP:0000193)2.62214370
66Gastrointestinal inflammation (HP:0004386)2.61800042
67Polycythemia (HP:0001901)2.56991092
68Basal cell carcinoma (HP:0002671)2.56202949
69IgA deficiency (HP:0002720)2.54521779
70Patellar aplasia (HP:0006443)2.49328212
71Selective tooth agenesis (HP:0001592)2.49209985
72Congenital hip dislocation (HP:0001374)2.49114088
73Hypokinesia (HP:0002375)2.48807268
74Growth hormone excess (HP:0000845)2.48500736
75Broad face (HP:0000283)2.47891641
76Distal lower limb muscle weakness (HP:0009053)2.45309470
77Increased serum ferritin (HP:0003281)2.45101857
78Autoimmune thrombocytopenia (HP:0001973)2.45007511
79Short chin (HP:0000331)2.44289527
80Joint stiffness (HP:0001387)2.44155190
81Hypotrichosis (HP:0001006)2.40679537
82Increased neuronal autofluorescent lipopigment (HP:0002074)2.39452400
83Abnormality of aromatic amino acid family metabolism (HP:0004338)2.37373419
84Loss of speech (HP:0002371)2.37249397
85Broad alveolar ridges (HP:0000187)2.36886269
86Cheilitis (HP:0100825)2.36517158
87Large for gestational age (HP:0001520)2.35792466
88Aplasia of the musculature (HP:0100854)2.32978288
89Hypoplasia of the radius (HP:0002984)2.32352348
90Achilles tendon contracture (HP:0001771)2.31972803
91Lower limb hyperreflexia (HP:0002395)2.31761052
92Inflammation of the large intestine (HP:0002037)2.31472708
93Flat acetabular roof (HP:0003180)2.30727815
94Thoracic kyphosis (HP:0002942)2.30286270
95Abnormality of the thoracic spine (HP:0100711)2.29983190
96Recurrent abscess formation (HP:0002722)2.29809128
97Cerebral aneurysm (HP:0004944)2.29220417
98Aplasia/Hypoplasia of the patella (HP:0006498)2.28087807
99Amyloidosis (HP:0011034)2.27314584
100Volvulus (HP:0002580)2.26065387
101Choanal stenosis (HP:0000452)2.25684253
102Vacuolated lymphocytes (HP:0001922)2.25099114
103Hypertriglyceridemia (HP:0002155)2.24818837
104Delayed epiphyseal ossification (HP:0002663)2.24361322
105Axonal loss (HP:0003447)2.24325516
106Hypophosphatemia (HP:0002148)2.22410893
107Abnormality of endocrine pancreas physiology (HP:0012093)2.22352070
108Abnormality of the pancreatic islet cells (HP:0006476)2.22352070
109Premature graying of hair (HP:0002216)2.22220184
110Diaphragmatic weakness (HP:0009113)2.22034006
111Muscle fiber atrophy (HP:0100295)2.21557303
112Abnormal delayed hypersensitivity skin test (HP:0002963)2.19630505
113Distal lower limb amyotrophy (HP:0008944)2.18771809
114Abnormality of monocarboxylic acid metabolism (HP:0010996)2.18256919
115Vertebral compression fractures (HP:0002953)2.17946082
116Hamartoma (HP:0010566)2.17025990
117Increased connective tissue (HP:0009025)2.16113918
118Hand muscle atrophy (HP:0009130)2.15739414
119Bowing of the arm (HP:0006488)2.15298918
120Bowed forearm bones (HP:0003956)2.15298918
121Capillary hemangiomas (HP:0005306)2.14866152
122Recurrent bacterial skin infections (HP:0005406)2.13767780
123Abnormality of the Achilles tendon (HP:0005109)2.12910687
124Intrahepatic cholestasis (HP:0001406)2.12247243
125Bone pain (HP:0002653)2.12174310
126Redundant skin (HP:0001582)2.11994000
127Hypotelorism (HP:0000601)2.09298431
128Myocardial infarction (HP:0001658)2.09006843
129Exertional dyspnea (HP:0002875)2.08184312
130Acute lymphatic leukemia (HP:0006721)2.07625110
131Type 2 muscle fiber atrophy (HP:0003554)2.05682469
132Amelogenesis imperfecta (HP:0000705)2.05180977
133Abnormality of placental membranes (HP:0011409)2.04763459
134Amniotic constriction ring (HP:0009775)2.04763459
135Opisthotonus (HP:0002179)2.03568457
136Abnormal trabecular bone morphology (HP:0100671)2.00702114
137Cellulitis (HP:0100658)2.00562839
138Decreased lacrimation (HP:0000633)1.98985644
139Bulbar palsy (HP:0001283)1.98953810
140Petechiae (HP:0000967)1.97880873
141Easy fatigability (HP:0003388)1.96696577
142Myopathic facies (HP:0002058)1.96630908
143Progressive neurologic deterioration (HP:0002344)1.96588542
144Hypoplasia of the ulna (HP:0003022)1.96381451
145Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.96192842
146Nuclear cataract (HP:0100018)1.96063499
147Clumsiness (HP:0002312)1.95937904
148Prolonged neonatal jaundice (HP:0006579)1.95888319
149Popliteal pterygium (HP:0009756)1.95552213
150Short 5th finger (HP:0009237)1.93732372
151Mediastinal lymphadenopathy (HP:0100721)1.92806942
152Gastrointestinal dysmotility (HP:0002579)1.92607090
153Reticulocytosis (HP:0001923)1.91572803
154Elevated alkaline phosphatase (HP:0003155)1.91042422
155Aplasia/Hypoplasia involving the musculature (HP:0001460)1.89477155
156Increased IgE level (HP:0003212)1.88784749
157Abdominal distention (HP:0003270)1.88542219
158Chronic obstructive pulmonary disease (HP:0006510)1.88073619
159Obstructive lung disease (HP:0006536)1.88073619
160Autoimmune hemolytic anemia (HP:0001890)1.87017652
161Abnormality of alkaline phosphatase activity (HP:0004379)1.86576967
162Abnormality of glutamine family amino acid metabolism (HP:0010902)1.86117776
163Deep venous thrombosis (HP:0002625)1.85919245
164Generalized amyotrophy (HP:0003700)1.85901647
165Xanthomatosis (HP:0000991)1.85120187
166Purpura (HP:0000979)1.83090129
167Abnormal enzyme/coenzyme activity (HP:0012379)1.81888183
168Granulocytopenia (HP:0001913)1.81060211
169Neuronal loss in central nervous system (HP:0002529)1.80058520
170Abnormality of complement system (HP:0005339)1.79566120
171Abnormality of iron homeostasis (HP:0011031)1.77744047
172Upper motor neuron abnormality (HP:0002127)1.77623725
173Deformed sella turcica (HP:0002681)1.76508090
174Abnormality of the distal phalanges of the toes (HP:0010182)1.76190482
175Recurrent fungal infections (HP:0002841)1.76082646
176Flattened epiphyses (HP:0003071)1.75874976
177Hepatosplenomegaly (HP:0001433)1.74360748
178Rough bone trabeculation (HP:0100670)1.74335852
179Disproportionate tall stature (HP:0001519)1.73737240
180Long palpebral fissure (HP:0000637)1.73142914
181Cholecystitis (HP:0001082)1.71986121
182Abnormal gallbladder physiology (HP:0012438)1.71986121
183Obstructive sleep apnea (HP:0002870)1.71121854
184Interstitial pulmonary disease (HP:0006530)1.70857324
185Gingivitis (HP:0000230)1.70492284
186Asymmetric septal hypertrophy (HP:0001670)1.68266698

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.77724421
2MAPK155.67036060
3MAP3K64.59609623
4DDR24.57382828
5MAP3K113.58319187
6MATK3.15964283
7PINK13.04414445
8MAP2K33.00412156
9PIM22.76750543
10TYRO32.72390732
11DAPK12.46748928
12IRAK32.44115883
13FGR2.43865451
14CSK2.32953398
15YES12.26038747
16TESK12.22676710
17PRKD22.20714130
18TESK22.04399518
19SMG12.03306938
20DYRK1B2.01154514
21AKT32.00116375
22UHMK11.92243947
23CDK71.90059049
24BMX1.89059908
25PDGFRA1.78410862
26IRAK41.75311839
27MAP3K31.72401006
28TBK11.70695538
29PKN21.62776477
30ZAP701.58717450
31TYK21.58209587
32BLK1.55555774
33GRK61.52116795
34PIM11.50411690
35MAPK111.43764875
36RIPK41.43409177
37CDK61.35237789
38TRPM71.33439564
39CAMKK11.30215601
40RIPK11.30183214
41MAP3K131.29482783
42RPS6KC11.25026495
43RPS6KL11.25026495
44SIK31.24675472
45MAP3K141.23918505
46PTK61.21921939
47MAP2K61.19110356
48TTN1.17141234
49EPHB11.16896292
50SIK21.11961927
51RPS6KA61.10501539
52MAP3K101.10358430
53DYRK31.07577819
54EEF2K1.06935254
55KDR1.05942412
56GSK3A1.02124525
57CDC42BPA1.00837291
58CHEK21.00380575
59PDPK11.00139384
60LATS20.90018350
61MAP3K10.88959532
62BCKDK0.88871100
63RPS6KB20.88040377
64PLK10.86113994
65RPS6KA20.83383221
66TAOK20.81117025
67EPHA20.80158721
68PRKG20.79931263
69ARAF0.79623469
70RAF10.76841180
71STK38L0.76629775
72CSF1R0.76295469
73JAK30.74485176
74LMTK20.72662812
75BTK0.72650299
76PHKG10.69043389
77PHKG20.69043389
78MARK20.67648436
79ATR0.66886556
80MTOR0.65918020
81HIPK20.64410784
82FES0.63263119
83MAPK120.61271719
84PASK0.60825326
85ABL20.59768879
86RPS6KA10.59419954
87PRKAA10.59254518
88BUB10.57662194
89LYN0.57324422
90ERN10.55561648
91PDK10.53147163
92TNK20.51880234
93MAP3K80.51194126
94CSNK2A10.50708091
95IRAK20.50476168
96ACVR1B0.50125676
97HCK0.50101854
98RPS6KB10.48469035
99MET0.48234161
100NEK20.47884058
101SIK10.46912669
102FLT30.44168340
103ERBB30.43944213
104IKBKE0.43251559
105MAPKAPK30.42455223
106MAPK30.41990165
107EPHB20.41770448
108CDK20.41638669
109SYK0.41213543
110PRPF4B0.40797833
111ILK0.40169214
112STK380.39927079
113PDK20.38961208
114PRKD10.38048326
115CAMKK20.37888375
116AURKA0.37778122
117TLK10.37008457
118CAMK2G0.36719152
119IKBKB0.35879381
120MAPK40.35546483
121MAP4K10.35492193
122EGFR0.35232774
123AURKB0.34664793
124CSNK2A20.34138580
125PRKAA20.33750118
126MAPK10.32289061
127CHUK0.31052803
128DYRK20.29323274
129CDK40.28588115
130MST1R0.27753556
131TRIB30.27336137
132CDK80.27053123
133MST40.26863921
134MAP2K20.25454721
135CHEK10.24339733
136FGFR40.23998290
137MAPKAPK20.23919583
138PDGFRB0.23545032
139MAPK140.23442441
140ATM0.22488291
141TAOK30.21600924
142TAOK10.20791402
143PAK20.20437288
144PRKCI0.20383007
145WEE10.19600459
146NME20.19257004
147PTK20.19225025
148PRKCD0.19155505
149INSR0.19047079
150CSNK1G10.18746660
151LCK0.18025769
152PAK40.16308236
153CDC70.16268416

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.98149523
2Mismatch repair_Homo sapiens_hsa034304.47029684
3Fatty acid biosynthesis_Homo sapiens_hsa000614.05956407
4Base excision repair_Homo sapiens_hsa034104.04037379
5DNA replication_Homo sapiens_hsa030303.55166876
6Sulfur relay system_Homo sapiens_hsa041222.49716750
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.27075384
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.08833996
9Folate biosynthesis_Homo sapiens_hsa007902.08237893
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.04460538
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.04191967
12Arginine and proline metabolism_Homo sapiens_hsa003302.00450681
13Nucleotide excision repair_Homo sapiens_hsa034201.98214994
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.93400448
15Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.92761759
16Lysosome_Homo sapiens_hsa041421.91783288
17Homologous recombination_Homo sapiens_hsa034401.91076016
18Fatty acid metabolism_Homo sapiens_hsa012121.85996640
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.84746125
20Osteoclast differentiation_Homo sapiens_hsa043801.81410444
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.80189991
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.79819290
23Biosynthesis of amino acids_Homo sapiens_hsa012301.78788935
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.66229006
25Leishmaniasis_Homo sapiens_hsa051401.65246011
26Spliceosome_Homo sapiens_hsa030401.58606958
27B cell receptor signaling pathway_Homo sapiens_hsa046621.57216206
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.55326076
29Arginine biosynthesis_Homo sapiens_hsa002201.54198064
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.51412493
31Fanconi anemia pathway_Homo sapiens_hsa034601.51108163
32VEGF signaling pathway_Homo sapiens_hsa043701.51093003
33Ribosome_Homo sapiens_hsa030101.48866539
34RNA transport_Homo sapiens_hsa030131.43151892
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.41137896
36TNF signaling pathway_Homo sapiens_hsa046681.39364826
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.37761690
38Tuberculosis_Homo sapiens_hsa051521.37303842
39Circadian rhythm_Homo sapiens_hsa047101.37261469
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.35242177
41Fructose and mannose metabolism_Homo sapiens_hsa000511.34674753
42One carbon pool by folate_Homo sapiens_hsa006701.34347238
43mRNA surveillance pathway_Homo sapiens_hsa030151.29613429
44Staphylococcus aureus infection_Homo sapiens_hsa051501.26545043
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.26135521
46Pertussis_Homo sapiens_hsa051331.25763119
47Selenocompound metabolism_Homo sapiens_hsa004501.23526544
48p53 signaling pathway_Homo sapiens_hsa041151.21765458
49Notch signaling pathway_Homo sapiens_hsa043301.20955769
50Hepatitis C_Homo sapiens_hsa051601.19169619
51Toxoplasmosis_Homo sapiens_hsa051451.17445745
52Lysine degradation_Homo sapiens_hsa003101.16168170
53Tryptophan metabolism_Homo sapiens_hsa003801.14148652
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12331860
55Pentose phosphate pathway_Homo sapiens_hsa000301.10477661
56Salmonella infection_Homo sapiens_hsa051321.10149653
57Allograft rejection_Homo sapiens_hsa053301.09846738
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09424789
59Apoptosis_Homo sapiens_hsa042101.08429921
60Drug metabolism - other enzymes_Homo sapiens_hsa009831.07401837
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.06899443
62Hippo signaling pathway_Homo sapiens_hsa043901.06822720
63Influenza A_Homo sapiens_hsa051641.05694915
64Chronic myeloid leukemia_Homo sapiens_hsa052201.01894434
65Hedgehog signaling pathway_Homo sapiens_hsa043401.01486127
66Adherens junction_Homo sapiens_hsa045201.01026755
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.99641473
68Fatty acid degradation_Homo sapiens_hsa000710.98871777
69Primary immunodeficiency_Homo sapiens_hsa053400.98360686
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98319570
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.97973066
72Glutathione metabolism_Homo sapiens_hsa004800.96416466
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94669787
74Galactose metabolism_Homo sapiens_hsa000520.94610908
75Bladder cancer_Homo sapiens_hsa052190.93946667
76T cell receptor signaling pathway_Homo sapiens_hsa046600.93238084
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92712184
78Endocytosis_Homo sapiens_hsa041440.92105093
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89442204
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89409571
81Steroid biosynthesis_Homo sapiens_hsa001000.89270512
82mTOR signaling pathway_Homo sapiens_hsa041500.88748701
83Renin-angiotensin system_Homo sapiens_hsa046140.88508235
84Vibrio cholerae infection_Homo sapiens_hsa051100.87214812
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.86799139
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86022309
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85503464
88Malaria_Homo sapiens_hsa051440.85292105
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.84052303
90Sphingolipid metabolism_Homo sapiens_hsa006000.82575474
91Cell cycle_Homo sapiens_hsa041100.82247230
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.82136646
93Hepatitis B_Homo sapiens_hsa051610.82052191
94Fat digestion and absorption_Homo sapiens_hsa049750.81552802
95Sulfur metabolism_Homo sapiens_hsa009200.78652782
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.78621212
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76646098
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75921753
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.75464197
100Autoimmune thyroid disease_Homo sapiens_hsa053200.74768450
101Pyrimidine metabolism_Homo sapiens_hsa002400.74389169
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.74065538
103Antigen processing and presentation_Homo sapiens_hsa046120.73960500
104Proteasome_Homo sapiens_hsa030500.73908091
105TGF-beta signaling pathway_Homo sapiens_hsa043500.73899234
106Phagosome_Homo sapiens_hsa041450.73870278
107Prion diseases_Homo sapiens_hsa050200.73727139
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.73423494
109Viral myocarditis_Homo sapiens_hsa054160.72941534
110Insulin resistance_Homo sapiens_hsa049310.72274256
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70738489
112Chemical carcinogenesis_Homo sapiens_hsa052040.69997551
113Graft-versus-host disease_Homo sapiens_hsa053320.68767688
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68101892
115Viral carcinogenesis_Homo sapiens_hsa052030.67497905
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67130024
117Fatty acid elongation_Homo sapiens_hsa000620.66928576
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.66839328
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66264997
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65723159
121African trypanosomiasis_Homo sapiens_hsa051430.65463314
122Shigellosis_Homo sapiens_hsa051310.63938897
123Vitamin digestion and absorption_Homo sapiens_hsa049770.63435627
124Non-small cell lung cancer_Homo sapiens_hsa052230.62866986
125AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62091118
126Hematopoietic cell lineage_Homo sapiens_hsa046400.60854119
127Rheumatoid arthritis_Homo sapiens_hsa053230.60222576
128ABC transporters_Homo sapiens_hsa020100.59286527
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59086176
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59026765
131Complement and coagulation cascades_Homo sapiens_hsa046100.58769664
132Pancreatic cancer_Homo sapiens_hsa052120.57555333
133Measles_Homo sapiens_hsa051620.56328470
134Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56168863
135Starch and sucrose metabolism_Homo sapiens_hsa005000.56034748
136Retinol metabolism_Homo sapiens_hsa008300.54435236
137Chemokine signaling pathway_Homo sapiens_hsa040620.54197517
138Peroxisome_Homo sapiens_hsa041460.53606606
139GnRH signaling pathway_Homo sapiens_hsa049120.53490359
140Legionellosis_Homo sapiens_hsa051340.52678045
141Asthma_Homo sapiens_hsa053100.52611576
142Insulin signaling pathway_Homo sapiens_hsa049100.52263974
143Tyrosine metabolism_Homo sapiens_hsa003500.51407995
144Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50827233
145Carbon metabolism_Homo sapiens_hsa012000.50646297
146Histidine metabolism_Homo sapiens_hsa003400.50643972
147Pyruvate metabolism_Homo sapiens_hsa006200.49789995
148Inositol phosphate metabolism_Homo sapiens_hsa005620.49699709
149Basal cell carcinoma_Homo sapiens_hsa052170.49670905
150Prolactin signaling pathway_Homo sapiens_hsa049170.49481485
151Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48940621
152Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48704528
153Phospholipase D signaling pathway_Homo sapiens_hsa040720.47898182
154beta-Alanine metabolism_Homo sapiens_hsa004100.47837338
155Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47795143
156Caffeine metabolism_Homo sapiens_hsa002320.46152281
157RNA polymerase_Homo sapiens_hsa030200.45862287
158Steroid hormone biosynthesis_Homo sapiens_hsa001400.43496969
159Platelet activation_Homo sapiens_hsa046110.43005123
160HTLV-I infection_Homo sapiens_hsa051660.42401236
161Metabolic pathways_Homo sapiens_hsa011000.42175152
162Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40790658
163Wnt signaling pathway_Homo sapiens_hsa043100.40588176
164Amoebiasis_Homo sapiens_hsa051460.39744636
165N-Glycan biosynthesis_Homo sapiens_hsa005100.38860970
166Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38512970
167Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38468960
168Thyroid cancer_Homo sapiens_hsa052160.36746523
169Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36449679
170Propanoate metabolism_Homo sapiens_hsa006400.35157781
171Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33492795
172Phenylalanine metabolism_Homo sapiens_hsa003600.31559491
173Acute myeloid leukemia_Homo sapiens_hsa052210.31380807
174Herpes simplex infection_Homo sapiens_hsa051680.30206491
175Glycerolipid metabolism_Homo sapiens_hsa005610.28859433
176Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27417193
177PPAR signaling pathway_Homo sapiens_hsa033200.26606588

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