ADCY1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)6.77562856
2synaptic vesicle maturation (GO:0016188)6.46487673
3regulation of short-term neuronal synaptic plasticity (GO:0048172)6.35286518
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.07984207
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.99730499
6vocalization behavior (GO:0071625)5.76160420
7glutamate secretion (GO:0014047)5.55151775
8synaptic vesicle exocytosis (GO:0016079)5.41729307
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.37560424
10ionotropic glutamate receptor signaling pathway (GO:0035235)5.26912058
11synaptic vesicle docking involved in exocytosis (GO:0016081)5.24330209
12neuronal action potential propagation (GO:0019227)5.22303846
13regulation of synaptic vesicle exocytosis (GO:2000300)5.06255290
14exploration behavior (GO:0035640)4.99486044
15regulation of glutamate receptor signaling pathway (GO:1900449)4.90495693
16glutamate receptor signaling pathway (GO:0007215)4.86123567
17synaptic transmission, glutamatergic (GO:0035249)4.83828836
18cerebellar granule cell differentiation (GO:0021707)4.83021586
19gamma-aminobutyric acid transport (GO:0015812)4.81553293
20layer formation in cerebral cortex (GO:0021819)4.77092054
21neurotransmitter secretion (GO:0007269)4.75416454
22cellular potassium ion homeostasis (GO:0030007)4.65895505
23positive regulation of synapse maturation (GO:0090129)4.63087831
24protein localization to synapse (GO:0035418)4.61450349
25sodium ion export (GO:0071436)4.56676667
26regulation of long-term neuronal synaptic plasticity (GO:0048169)4.52643639
27regulation of synaptic vesicle transport (GO:1902803)4.48700566
28regulation of neuronal synaptic plasticity (GO:0048168)4.43545145
29dendritic spine morphogenesis (GO:0060997)4.33145637
30regulation of synapse structural plasticity (GO:0051823)4.29947986
31neurotransmitter-gated ion channel clustering (GO:0072578)4.29271780
32cerebellar Purkinje cell differentiation (GO:0021702)4.28314091
33neuron-neuron synaptic transmission (GO:0007270)4.27194315
34G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.25667497
35response to pheromone (GO:0019236)4.06522937
36positive regulation of membrane potential (GO:0045838)4.03464929
37regulation of excitatory postsynaptic membrane potential (GO:0060079)4.03435756
38* long-term memory (GO:0007616)4.00687668
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.98101150
40neuron cell-cell adhesion (GO:0007158)3.96046230
41presynaptic membrane assembly (GO:0097105)3.93499005
42proline transport (GO:0015824)3.92492019
43cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.91440358
44presynaptic membrane organization (GO:0097090)3.90226922
45neuromuscular process controlling balance (GO:0050885)3.88922906
46dendrite morphogenesis (GO:0048813)3.82163109
47regulation of postsynaptic membrane potential (GO:0060078)3.79120677
48gamma-aminobutyric acid signaling pathway (GO:0007214)3.75747402
49regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.74998959
50neurotransmitter transport (GO:0006836)3.71375839
51positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.68152989
52cell communication by electrical coupling (GO:0010644)3.65487025
53neuronal ion channel clustering (GO:0045161)3.65440749
54regulation of dendritic spine morphogenesis (GO:0061001)3.61534309
55regulation of synaptic plasticity (GO:0048167)3.59971023
56synaptic vesicle endocytosis (GO:0048488)3.58881184
57amino acid import (GO:0043090)3.57645794
58cell migration in hindbrain (GO:0021535)3.57187869
59negative regulation of dendrite morphogenesis (GO:0050774)3.56890421
60regulation of ARF protein signal transduction (GO:0032012)3.56735071
61cell differentiation in hindbrain (GO:0021533)3.56017145
62transmission of nerve impulse (GO:0019226)3.55890447
63regulation of neurotransmitter secretion (GO:0046928)3.55888425
64potassium ion homeostasis (GO:0055075)3.54581916
65regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.52225302
66regulation of synapse maturation (GO:0090128)3.47588998
67regulation of neurotransmitter levels (GO:0001505)3.45472875
68positive regulation of neurotransmitter secretion (GO:0001956)3.40111437
69neuromuscular process controlling posture (GO:0050884)3.39201424
70establishment of mitochondrion localization (GO:0051654)3.38446071
71membrane depolarization during action potential (GO:0086010)3.37613873
72establishment of nucleus localization (GO:0040023)3.35904708
73positive regulation of neurotransmitter transport (GO:0051590)3.35513371
74regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.33458684
75positive regulation of dendritic spine morphogenesis (GO:0061003)3.31654673
76membrane depolarization (GO:0051899)3.31557085
77auditory behavior (GO:0031223)3.31187658
78neuron recognition (GO:0008038)3.30427381
79positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.29894684
80negative regulation of synaptic transmission, GABAergic (GO:0032229)3.29538803
81long-term synaptic potentiation (GO:0060291)3.28331342
82regulation of synaptic transmission, glutamatergic (GO:0051966)3.28249649
83cellular sodium ion homeostasis (GO:0006883)3.25121641
84axonal fasciculation (GO:0007413)3.24457439
85G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.24184838
86neuromuscular synaptic transmission (GO:0007274)3.23421834
87glycine transport (GO:0015816)3.23189823
88dendritic spine organization (GO:0097061)3.22023947
89positive regulation of dendritic spine development (GO:0060999)3.22020147
90postsynaptic membrane organization (GO:0001941)3.21989742
91regulation of vesicle fusion (GO:0031338)3.21247286
92regulation of neurotransmitter transport (GO:0051588)3.20206145
93innervation (GO:0060384)3.20145864
94potassium ion import (GO:0010107)3.19684584
95L-amino acid import (GO:0043092)3.19352126
96long term synaptic depression (GO:0060292)3.14104253
97neuromuscular process (GO:0050905)3.12995153
98chemosensory behavior (GO:0007635)3.12376191
99startle response (GO:0001964)3.10254166
100cell communication involved in cardiac conduction (GO:0086065)3.09392849
101synapse assembly (GO:0007416)3.09075770
102positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.08428862
103regulation of voltage-gated calcium channel activity (GO:1901385)3.07659651
104adult walking behavior (GO:0007628)3.07274804
105membrane hyperpolarization (GO:0060081)3.05630448
106mechanosensory behavior (GO:0007638)3.04390893
107establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.03201221
108mitochondrion transport along microtubule (GO:0047497)3.03201221
109regulation of dendritic spine development (GO:0060998)3.02728734
110regulation of calcium ion-dependent exocytosis (GO:0017158)3.02680023
111regulation of dendrite morphogenesis (GO:0048814)3.02526989
112positive regulation of dendrite development (GO:1900006)3.02061022
113response to auditory stimulus (GO:0010996)3.00414171
114central nervous system projection neuron axonogenesis (GO:0021952)3.00370831
115learning (GO:0007612)3.00276264
116regulation of synaptic transmission (GO:0050804)2.99192139
117social behavior (GO:0035176)2.99058620
118intraspecies interaction between organisms (GO:0051703)2.99058620
119regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.98805975
120vesicle transport along microtubule (GO:0047496)2.96115378

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.06941495
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.15727753
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.05520765
4GBX2_23144817_ChIP-Seq_PC3_Human3.03360695
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.99999246
6* DROSHA_22980978_ChIP-Seq_HELA_Human2.85239595
7REST_21632747_ChIP-Seq_MESCs_Mouse2.81218681
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.79026474
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.79026474
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.60007754
11* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.59108365
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57455156
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.52970626
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50962782
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50329421
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44521349
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.42253110
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.35935296
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.33554720
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.32918185
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.31208675
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.30327964
23* RNF2_27304074_Chip-Seq_ESCs_Mouse2.20936666
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20516616
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.17621471
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.16721931
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.82320705
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79138195
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77536818
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.74281053
31AR_21572438_ChIP-Seq_LNCaP_Human1.73268805
32* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66214136
33SMAD4_21799915_ChIP-Seq_A2780_Human1.53981498
34ZNF274_21170338_ChIP-Seq_K562_Hela1.51533374
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47167476
36KDM2B_26808549_Chip-Seq_K562_Human1.41924144
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38911580
38RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.38786178
39RNF2_27304074_Chip-Seq_NSC_Mouse1.38538919
40AR_19668381_ChIP-Seq_PC3_Human1.33620848
41RING1B_27294783_Chip-Seq_ESCs_Mouse1.33370348
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31098784
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29791444
44SOX2_21211035_ChIP-Seq_LN229_Gbm1.29334236
45WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28380466
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24117756
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22859192
48* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22825334
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21754217
50GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21210863
51* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21187032
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.20300296
53ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19538446
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19091618
55RING1B_27294783_Chip-Seq_NPCs_Mouse1.18473992
56* STAT3_23295773_ChIP-Seq_U87_Human1.17116142
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15936579
58OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.14426626
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14142782
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13792547
61* AR_25329375_ChIP-Seq_VCAP_Human1.13668108
62TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13434006
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12962336
64TP53_16413492_ChIP-PET_HCT116_Human1.11099436
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.06614983
66CTCF_27219007_Chip-Seq_Bcells_Human1.05784361
67RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05195091
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.04605802
69GATA1_26923725_Chip-Seq_HPCs_Mouse1.04570947
70* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04415951
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04146382
72TCF4_23295773_ChIP-Seq_U87_Human1.03339274
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03159791
74ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02169649
75TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01462485
76P300_19829295_ChIP-Seq_ESCs_Human1.01321889
77P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99369402
78SMAD3_21741376_ChIP-Seq_ESCs_Human0.98071006
79AHR_22903824_ChIP-Seq_MCF-7_Human0.97305514
80SMAD4_21741376_ChIP-Seq_HESCs_Human0.97213847
81ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96372094
82MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96170609
83* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95964684
84TET1_21490601_ChIP-Seq_MESCs_Mouse0.95854692
85TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95793935
86CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95410652
87PIAS1_25552417_ChIP-Seq_VCAP_Human0.94823111
88SMAD3_21741376_ChIP-Seq_HESCs_Human0.94572965
89SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94456425
90CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94443648
91ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93809625
92EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92017578
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90784590
94TAF15_26573619_Chip-Seq_HEK293_Human0.90636052
95RXR_22108803_ChIP-Seq_LS180_Human0.90535663
96KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90325922
97CBX2_27304074_Chip-Seq_ESCs_Mouse0.89999066
98SOX9_26525672_Chip-Seq_HEART_Mouse0.89801724
99CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89051712
100* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88689854
101LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88658066
102NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88651396
103DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88231980
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87609158
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87609158
106TP53_20018659_ChIP-ChIP_R1E_Mouse0.87547280
107RUNX2_22187159_ChIP-Seq_PCA_Human0.84967165
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84675238
109VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.82838638
110IGF1R_20145208_ChIP-Seq_DFB_Human0.81841337
111ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81724128
112ESR2_21235772_ChIP-Seq_MCF-7_Human0.81469696
113RBPJ_22232070_ChIP-Seq_NCS_Mouse0.81408586
114* DPY_21335234_ChIP-Seq_ESCs_Mouse0.78990613
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.78771596
116GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77736822

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0004859_abnormal_synaptic_plasticity7.09384025
2* MP0003635_abnormal_synaptic_transmissio4.50523400
3MP0004270_analgesia4.06688246
4MP0003880_abnormal_central_pattern3.98788507
5MP0009046_muscle_twitch3.95836122
6MP0009745_abnormal_behavioral_response3.52024458
7* MP0002063_abnormal_learning/memory/cond3.44116522
8MP0002064_seizures3.30677211
9MP0005423_abnormal_somatic_nervous3.00483181
10MP0001968_abnormal_touch/_nociception2.95559394
11* MP0002572_abnormal_emotion/affect_behav2.79522807
12MP0002272_abnormal_nervous_system2.79329993
13MP0008569_lethality_at_weaning2.75790944
14* MP0002734_abnormal_mechanical_nocicepti2.63873213
15MP0001486_abnormal_startle_reflex2.56777970
16MP0001440_abnormal_grooming_behavior2.34884123
17MP0001501_abnormal_sleep_pattern2.23717654
18MP0002736_abnormal_nociception_after2.22074600
19MP0002067_abnormal_sensory_capabilities2.20176637
20MP0003329_amyloid_beta_deposits2.13470774
21MP0002184_abnormal_innervation2.10891282
22MP0009780_abnormal_chondrocyte_physiolo2.09122066
23MP0002733_abnormal_thermal_nociception2.03303714
24MP0004858_abnormal_nervous_system1.89922116
25MP0000778_abnormal_nervous_system1.88695250
26MP0004811_abnormal_neuron_physiology1.88652498
27MP0002557_abnormal_social/conspecific_i1.81807849
28MP0004885_abnormal_endolymph1.81559255
29* MP0001970_abnormal_pain_threshold1.81473641
30MP0004924_abnormal_behavior1.76265424
31MP0005386_behavior/neurological_phenoty1.76265424
32* MP0002735_abnormal_chemical_nociception1.73669324
33MP0003879_abnormal_hair_cell1.73073170
34MP0000955_abnormal_spinal_cord1.71389947
35MP0004145_abnormal_muscle_electrophysio1.70246023
36MP0003123_paternal_imprinting1.63123105
37MP0003122_maternal_imprinting1.62421616
38MP0002909_abnormal_adrenal_gland1.61755283
39MP0002066_abnormal_motor_capabilities/c1.55031941
40MP0002822_catalepsy1.54364502
41MP0003633_abnormal_nervous_system1.50378167
42MP0002882_abnormal_neuron_morphology1.48934916
43MP0000569_abnormal_digit_pigmentation1.39182119
44MP0003631_nervous_system_phenotype1.35700022
45MP0004142_abnormal_muscle_tone1.28227289
46MP0003632_abnormal_nervous_system1.24479815
47* MP0002152_abnormal_brain_morphology1.21201945
48MP0002638_abnormal_pupillary_reflex1.21001695
49MP0003787_abnormal_imprinting1.18205829
50MP0001984_abnormal_olfaction1.17411957
51MP0001502_abnormal_circadian_rhythm1.15655953
52MP0004742_abnormal_vestibular_system1.07184032
53MP0008872_abnormal_physiological_respon1.05216108
54MP0005646_abnormal_pituitary_gland1.01787338
55MP0002229_neurodegeneration1.01073868
56MP0003690_abnormal_glial_cell1.00697871
57MP0004510_myositis1.00000797
58MP0000604_amyloidosis0.99285112
59MP0003283_abnormal_digestive_organ0.97508127
60MP0000920_abnormal_myelination0.94666607
61MP0001177_atelectasis0.94079849
62MP0005551_abnormal_eye_electrophysiolog0.91416177
63MP0005645_abnormal_hypothalamus_physiol0.91237193
64MP0002069_abnormal_eating/drinking_beha0.90597974
65MP0003075_altered_response_to0.88149498
66MP0004215_abnormal_myocardial_fiber0.87566148
67MP0003121_genomic_imprinting0.86440004
68MP0008874_decreased_physiological_sensi0.85979315
69MP0006276_abnormal_autonomic_nervous0.83710570
70MP0003634_abnormal_glial_cell0.83653471
71MP0000751_myopathy0.83515527
72MP0008877_abnormal_DNA_methylation0.82798727
73MP0005409_darkened_coat_color0.81475797
74MP0008961_abnormal_basal_metabolism0.81464843
75MP0001529_abnormal_vocalization0.81301395
76MP0004484_altered_response_of0.80522953
77MP0001963_abnormal_hearing_physiology0.79195015
78MP0004085_abnormal_heartbeat0.78143505
79MP0005187_abnormal_penis_morphology0.77701508
80MP0003137_abnormal_impulse_conducting0.77446550
81MP0004233_abnormal_muscle_weight0.74383247
82MP0001905_abnormal_dopamine_level0.71579708
83MP0005535_abnormal_body_temperature0.70994749
84MP0001346_abnormal_lacrimal_gland0.70849568
85MP0004147_increased_porphyrin_level0.70819906
86MP0002752_abnormal_somatic_nervous0.70095934
87MP0000013_abnormal_adipose_tissue0.69656069
88MP0004043_abnormal_pH_regulation0.69372349
89MP0002089_abnormal_postnatal_growth/wei0.69155056
90MP0002090_abnormal_vision0.68970199
91MP0010234_abnormal_vibrissa_follicle0.68954206
92MP0001299_abnormal_eye_distance/0.67989918
93MP0005623_abnormal_meninges_morphology0.67436220
94MP0005394_taste/olfaction_phenotype0.65280590
95MP0005499_abnormal_olfactory_system0.65280590
96MP0003861_abnormal_nervous_system0.65041505
97MP0000631_abnormal_neuroendocrine_gland0.64211333
98MP0010769_abnormal_survival0.63039787
99MP0001188_hyperpigmentation0.61909404
100MP0001485_abnormal_pinna_reflex0.61379796
101MP0005167_abnormal_blood-brain_barrier0.60841843
102MP0003172_abnormal_lysosome_physiology0.60801352
103MP0010768_mortality/aging0.59196565
104MP0004130_abnormal_muscle_cell0.58704439
105MP0001943_abnormal_respiration0.58086449
106MP0002082_postnatal_lethality0.57740286
107MP0010770_preweaning_lethality0.57740286
108MP0002249_abnormal_larynx_morphology0.57224546
109MP0001348_abnormal_lacrimal_gland0.57195475
110MP0003938_abnormal_ear_development0.55099674
111MP0000579_abnormal_nail_morphology0.54842656
112MP0003045_fibrosis0.54002054
113MP0010386_abnormal_urinary_bladder0.53606084
114MP0003956_abnormal_body_size0.53511841
115MP0002081_perinatal_lethality0.52615708
116MP0000026_abnormal_inner_ear0.50340425
117MP0005171_absent_coat_pigmentation0.49960668

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.04432058
2Myokymia (HP:0002411)6.80503293
3Visual hallucinations (HP:0002367)5.85193569
4Action tremor (HP:0002345)5.69929557
5Focal seizures (HP:0007359)5.65624009
6Progressive cerebellar ataxia (HP:0002073)5.62013557
7Epileptic encephalopathy (HP:0200134)4.62264026
8Gaze-evoked nystagmus (HP:0000640)4.58510995
9Atonic seizures (HP:0010819)4.39891988
10Febrile seizures (HP:0002373)4.30997348
11Broad-based gait (HP:0002136)4.11655252
12Dysdiadochokinesis (HP:0002075)3.96796173
13Absence seizures (HP:0002121)3.95218915
14Impaired smooth pursuit (HP:0007772)3.80986570
15Poor eye contact (HP:0000817)3.77301604
16Abnormality of the lower motor neuron (HP:0002366)3.69088801
17Scanning speech (HP:0002168)3.66907495
18Genetic anticipation (HP:0003743)3.63621285
19Generalized tonic-clonic seizures (HP:0002069)3.60418617
20Intention tremor (HP:0002080)3.58676379
21Dysmetria (HP:0001310)3.57982285
22Dysmetric saccades (HP:0000641)3.56986983
23Dialeptic seizures (HP:0011146)3.53327992
24Supranuclear gaze palsy (HP:0000605)3.49577421
25Mutism (HP:0002300)3.43561107
26Abnormality of ocular smooth pursuit (HP:0000617)3.42758783
27Hemiplegia (HP:0002301)3.39397731
28Impaired social interactions (HP:0000735)3.37813770
29Abnormal social behavior (HP:0012433)3.37813770
30Diplopia (HP:0000651)3.35492598
31Abnormality of binocular vision (HP:0011514)3.35492598
32Truncal ataxia (HP:0002078)3.35015482
33Depression (HP:0000716)3.19740081
34Ankle clonus (HP:0011448)3.17712477
35Impaired vibration sensation in the lower limbs (HP:0002166)3.15760774
36Hemiparesis (HP:0001269)3.09541853
37Papilledema (HP:0001085)3.08086878
38Urinary bladder sphincter dysfunction (HP:0002839)2.89599801
39Postural instability (HP:0002172)2.88733430
40Amyotrophic lateral sclerosis (HP:0007354)2.87944934
41Abnormal eating behavior (HP:0100738)2.82580099
42Annular pancreas (HP:0001734)2.76538073
43Anxiety (HP:0000739)2.76273044
44Hyperventilation (HP:0002883)2.72520916
45Abnormality of the corticospinal tract (HP:0002492)2.65581171
46Drooling (HP:0002307)2.64860057
47Excessive salivation (HP:0003781)2.64860057
48Stereotypic behavior (HP:0000733)2.64415729
49Ventricular fibrillation (HP:0001663)2.64193142
50Status epilepticus (HP:0002133)2.62990630
51Spastic gait (HP:0002064)2.57310823
52Cerebral hypomyelination (HP:0006808)2.52689877
53Amblyopia (HP:0000646)2.50737788
54Urinary urgency (HP:0000012)2.47877355
55Megalencephaly (HP:0001355)2.44381739
56Neurofibrillary tangles (HP:0002185)2.42428890
57Tetraplegia (HP:0002445)2.41713908
58Fetal akinesia sequence (HP:0001989)2.36261829
59Bundle branch block (HP:0011710)2.35355936
60Abnormality of saccadic eye movements (HP:0000570)2.34705158
61Sleep apnea (HP:0010535)2.33908032
62Cerebral inclusion bodies (HP:0100314)2.33388433
63Epileptiform EEG discharges (HP:0011182)2.32828725
64Agitation (HP:0000713)2.32797686
65Obstructive sleep apnea (HP:0002870)2.30891857
66Bradykinesia (HP:0002067)2.29382853
67Pointed chin (HP:0000307)2.29269682
68Torticollis (HP:0000473)2.27570327
69Impaired vibratory sensation (HP:0002495)2.26046671
70EEG with generalized epileptiform discharges (HP:0011198)2.25831152
71Gait ataxia (HP:0002066)2.23368121
72Lower limb asymmetry (HP:0100559)2.23300012
73Focal dystonia (HP:0004373)2.22562642
74Progressive inability to walk (HP:0002505)2.21535212
75Inappropriate behavior (HP:0000719)2.19307290
76Hypsarrhythmia (HP:0002521)2.18791784
77Postural tremor (HP:0002174)2.16547330
78Absent speech (HP:0001344)2.15042645
79Horizontal nystagmus (HP:0000666)2.13007903
80Polyphagia (HP:0002591)2.10969638
81Limb ataxia (HP:0002070)2.07071563
82Neuronal loss in central nervous system (HP:0002529)2.06242900
83Diminished motivation (HP:0000745)2.04202295
84Termporal pattern (HP:0011008)2.03981319
85Insidious onset (HP:0003587)2.03981319
86Insomnia (HP:0100785)2.03019350
87Aqueductal stenosis (HP:0002410)2.02635317
88Clonus (HP:0002169)1.99943163
89Morphological abnormality of the pyramidal tract (HP:0002062)1.99513254
90Degeneration of the lateral corticospinal tracts (HP:0002314)1.99445623
91Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.99445623
92Generalized myoclonic seizures (HP:0002123)1.98160915
93Aplasia of the phalanges of the hand (HP:0009802)1.97582226
94Aplasia involving bones of the extremities (HP:0009825)1.97582226
95Aplasia involving bones of the upper limbs (HP:0009823)1.97582226
96Delusions (HP:0000746)1.91754876
97Lower limb amyotrophy (HP:0007210)1.91652576
98Apathy (HP:0000741)1.91461476
99Turricephaly (HP:0000262)1.90757419
100Incomplete penetrance (HP:0003829)1.90481769
101Lower limb muscle weakness (HP:0007340)1.89331869
102Pheochromocytoma (HP:0002666)1.89262608
103Spastic tetraparesis (HP:0001285)1.85746220
104Intellectual disability, profound (HP:0002187)1.85160453
105Peripheral hypomyelination (HP:0007182)1.84826491
106Craniofacial dystonia (HP:0012179)1.81172562
107Spinal canal stenosis (HP:0003416)1.75563733
108Bronchomalacia (HP:0002780)1.75077173
109Psychosis (HP:0000709)1.74873505
110Prolonged QT interval (HP:0001657)1.73869834
111Syncope (HP:0001279)1.72837219
112Inability to walk (HP:0002540)1.72668385
113Limb dystonia (HP:0002451)1.72460322
114Spastic tetraplegia (HP:0002510)1.72046083
115Rapidly progressive (HP:0003678)1.71281956
116Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.70916955
117Rigidity (HP:0002063)1.70088809
118CNS hypomyelination (HP:0003429)1.69971785
119Akinesia (HP:0002304)1.68404636
120Abnormality of salivation (HP:0100755)1.68353337
121Abnormality of the periventricular white matter (HP:0002518)1.68337873

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.22267793
2MAP3K94.08060082
3MARK14.07063718
4EPHA43.16875389
5MAP3K42.85719211
6MINK12.85396695
7DAPK22.80871802
8CAMKK12.51850327
9PAK62.44885868
10NTRK22.31584976
11MAP2K72.22251378
12CAMKK22.20189262
13PRKD32.04833192
14KSR21.94042689
15MAP2K41.85912161
16RIPK11.77559023
17STK381.75893557
18PRPF4B1.74000844
19NTRK11.61754437
20RIPK41.57462802
21CDK51.54618424
22CDK191.54122974
23KSR11.52427092
24DAPK11.49440702
25TNIK1.33042163
26SIK21.32820265
27MAPK131.32614315
28PRKCG1.32431352
29TYRO31.30007775
30PHKG11.27481381
31PHKG21.27481381
32CAMK11.15620163
33PLK21.15224180
34GRK51.13731897
35MAP3K21.12923427
36PNCK1.10053461
37STK111.08929939
38ALK1.05747691
39MAP3K121.05038446
40LATS20.99945946
41CDK150.99685770
42TAOK10.99366242
43CDK180.97806635
44WNK10.97539869
45PRKCH0.97093437
46UHMK10.93475568
47RET0.91830587
48SGK2230.90746872
49SGK4940.90746872
50CASK0.89520830
51CDK140.88230725
52CDK11A0.87162046
53CAMK2A0.83714848
54FES0.83415248
55MARK20.82977238
56SGK20.82433570
57SGK30.82294943
58PDK10.81239390
59MAP3K130.79696620
60DYRK1A0.79205117
61CAMK2B0.77571564
62FGFR20.76239455
63PINK10.75801043
64SCYL20.74717395
65OXSR10.73085068
66SGK10.72293843
67CAMK40.69597329
68DYRK20.69068070
69CSNK1G20.68319412
70PAK30.66774472
71CAMK1G0.66671814
72PDPK10.66477381
73ARAF0.65349697
74LMTK20.63805400
75RAF10.63499856
76CDC42BPA0.60024881
77PTK2B0.59424949
78FYN0.56934420
79RPS6KA30.55988830
80MAP3K70.55533228
81PRKCZ0.53084348
82CAMK1D0.50196626
83CAMK2G0.49185925
84MAPK120.48518020
85ERBB30.46927415
86BMPR20.43820502
87NEK60.43237846
88NEK10.41010345
89MAPK100.40819944
90CSNK1D0.40742231
91CAMK2D0.40347317
92BRSK10.39926835
93MAP3K60.39670939
94ERBB20.39491968
95RPS6KB10.38933306
96DMPK0.37447154
97PRKCE0.36127992
98MAP3K10.35861693
99CSNK1E0.35466526
100PRKG10.34954593
101TRIB30.34823619
102ICK0.33476860
103DAPK30.33322565
104MAPK80.33224550
105BRAF0.32369803
106PKN10.32320797
107GSK3B0.32100265
108MAP2K60.31423996
109PRKCB0.31247700
110CCNB10.31207178
111ROCK20.30269929
112RPS6KA20.28240019
113PRKDC0.26657732
114PRKCA0.25654275

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.87988125
2Synaptic vesicle cycle_Homo sapiens_hsa047213.07488860
3* Glutamatergic synapse_Homo sapiens_hsa047242.85219819
4* Long-term potentiation_Homo sapiens_hsa047202.84113167
5* Circadian entrainment_Homo sapiens_hsa047132.77755524
6* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.69032311
7* GABAergic synapse_Homo sapiens_hsa047272.54032237
8Olfactory transduction_Homo sapiens_hsa047402.46858845
9Amphetamine addiction_Homo sapiens_hsa050312.39545642
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.36919557
11* Morphine addiction_Homo sapiens_hsa050322.30784149
12* Salivary secretion_Homo sapiens_hsa049702.18873431
13Dopaminergic synapse_Homo sapiens_hsa047282.10746977
14Long-term depression_Homo sapiens_hsa047302.09685106
15* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.92960454
16* Gastric acid secretion_Homo sapiens_hsa049711.89190242
17* Cholinergic synapse_Homo sapiens_hsa047251.84618402
18* Insulin secretion_Homo sapiens_hsa049111.83864684
19Taste transduction_Homo sapiens_hsa047421.83629603
20* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69023898
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.66210040
22* Oxytocin signaling pathway_Homo sapiens_hsa049211.66199925
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.57290376
24Renin secretion_Homo sapiens_hsa049241.54559693
25* Calcium signaling pathway_Homo sapiens_hsa040201.52614032
26Type II diabetes mellitus_Homo sapiens_hsa049301.50039805
27Vitamin B6 metabolism_Homo sapiens_hsa007501.44852003
28Serotonergic synapse_Homo sapiens_hsa047261.43310014
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.42699737
30* GnRH signaling pathway_Homo sapiens_hsa049121.38471061
31Nitrogen metabolism_Homo sapiens_hsa009101.33904302
32* cAMP signaling pathway_Homo sapiens_hsa040241.29418190
33Cocaine addiction_Homo sapiens_hsa050301.28998831
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23929190
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21960486
36* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21814055
37Glioma_Homo sapiens_hsa052141.21196525
38* Gap junction_Homo sapiens_hsa045401.20834807
39* Estrogen signaling pathway_Homo sapiens_hsa049151.19916343
40Axon guidance_Homo sapiens_hsa043601.10339311
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09449350
42ErbB signaling pathway_Homo sapiens_hsa040121.07104335
43* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06794323
44* Pancreatic secretion_Homo sapiens_hsa049720.95055480
45* Phospholipase D signaling pathway_Homo sapiens_hsa040720.92024036
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91079763
47* Melanogenesis_Homo sapiens_hsa049160.90616737
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88765276
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84451169
50* Oocyte meiosis_Homo sapiens_hsa041140.83546432
51Choline metabolism in cancer_Homo sapiens_hsa052310.83356689
52Dorso-ventral axis formation_Homo sapiens_hsa043200.81150059
53* Vascular smooth muscle contraction_Homo sapiens_hsa042700.80724889
54* Thyroid hormone synthesis_Homo sapiens_hsa049180.80120845
55Cardiac muscle contraction_Homo sapiens_hsa042600.77478658
56Collecting duct acid secretion_Homo sapiens_hsa049660.77325741
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.75375851
58VEGF signaling pathway_Homo sapiens_hsa043700.75226757
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74429117
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73653284
61MAPK signaling pathway_Homo sapiens_hsa040100.73362023
62mTOR signaling pathway_Homo sapiens_hsa041500.71900275
63Phototransduction_Homo sapiens_hsa047440.68995548
64Inositol phosphate metabolism_Homo sapiens_hsa005620.68006816
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66142603
66* Dilated cardiomyopathy_Homo sapiens_hsa054140.61306089
67* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61103109
68Glucagon signaling pathway_Homo sapiens_hsa049220.59589086
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.59493703
70Endometrial cancer_Homo sapiens_hsa052130.59385964
71Endocytosis_Homo sapiens_hsa041440.56141095
72Ras signaling pathway_Homo sapiens_hsa040140.52896777
73Circadian rhythm_Homo sapiens_hsa047100.51667559
74* Rap1 signaling pathway_Homo sapiens_hsa040150.51564639
75* Bile secretion_Homo sapiens_hsa049760.50991317
76Non-small cell lung cancer_Homo sapiens_hsa052230.50063145
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50009333
78Arginine biosynthesis_Homo sapiens_hsa002200.49480156
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48425881
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47728312
81Renal cell carcinoma_Homo sapiens_hsa052110.45730936
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45263301
83* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44948441
84AMPK signaling pathway_Homo sapiens_hsa041520.43943764
85Vibrio cholerae infection_Homo sapiens_hsa051100.43561246
86Wnt signaling pathway_Homo sapiens_hsa043100.42107134
87Hippo signaling pathway_Homo sapiens_hsa043900.40430969
88Alcoholism_Homo sapiens_hsa050340.40071732
89Insulin signaling pathway_Homo sapiens_hsa049100.39871587
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39241701
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37831103
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37211731
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36759627
94African trypanosomiasis_Homo sapiens_hsa051430.33127016
95Colorectal cancer_Homo sapiens_hsa052100.32825321
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32637768
97* Chemokine signaling pathway_Homo sapiens_hsa040620.32423484
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32112960
99* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31961297
100Arginine and proline metabolism_Homo sapiens_hsa003300.31547103
101* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30955368
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.30808533
103Fatty acid biosynthesis_Homo sapiens_hsa000610.30234073
104Prion diseases_Homo sapiens_hsa050200.28683417
105Type I diabetes mellitus_Homo sapiens_hsa049400.27248880
106Tight junction_Homo sapiens_hsa045300.26593898
107Prolactin signaling pathway_Homo sapiens_hsa049170.25836744
108Butanoate metabolism_Homo sapiens_hsa006500.24793817
109beta-Alanine metabolism_Homo sapiens_hsa004100.23526801
110Alzheimers disease_Homo sapiens_hsa050100.19527643
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18763848
112Histidine metabolism_Homo sapiens_hsa003400.17906476

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