ADCY10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hypercalciuria. Alternatively spliced transcript variants encoding different isoforms have been observed. There is a pseudogene of this gene on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.77191676
2cell-cell recognition (GO:0009988)9.71554862
3binding of sperm to zona pellucida (GO:0007339)9.67283848
4reproduction (GO:0000003)9.26243179
5spermatid development (GO:0007286)9.06141241
6cilium movement (GO:0003341)8.75962202
7piRNA metabolic process (GO:0034587)8.56323750
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.29911864
9regulation of cilium movement (GO:0003352)8.12766854
10male meiosis (GO:0007140)7.86040448
11single fertilization (GO:0007338)7.51060241
12sperm capacitation (GO:0048240)7.13055288
13synaptonemal complex organization (GO:0070193)7.10224783
14synaptonemal complex assembly (GO:0007130)6.82561464
15fertilization (GO:0009566)6.29554212
16microtubule depolymerization (GO:0007019)6.27307341
17* spermatogenesis (GO:0007283)6.02826168
18* male gamete generation (GO:0048232)6.00824337
19DNA methylation involved in gamete generation (GO:0043046)5.94767718
20negative regulation of inclusion body assembly (GO:0090084)5.63272194
21organic cation transport (GO:0015695)5.58506325
22* gamete generation (GO:0007276)5.53458175
23ventricular system development (GO:0021591)5.42136198
24male meiosis I (GO:0007141)5.29616836
25germ cell development (GO:0007281)5.21225409
26cellular process involved in reproduction in multicellular organism (GO:0022412)5.21047025
27calcium ion-dependent exocytosis (GO:0017156)5.14112762
28phospholipid efflux (GO:0033700)5.06241093
29chromosome organization involved in meiosis (GO:0070192)5.05148340
30regulation of inclusion body assembly (GO:0090083)4.74264154
31cell recognition (GO:0008037)4.72940074
32high-density lipoprotein particle remodeling (GO:0034375)4.67403652
33regulation of cholesterol esterification (GO:0010872)4.56162541
34meiotic nuclear division (GO:0007126)4.53489657
35spermatid nucleus differentiation (GO:0007289)4.50973375
36regulation of microtubule-based movement (GO:0060632)4.50558760
37glyoxylate metabolic process (GO:0046487)4.49161497
38seminiferous tubule development (GO:0072520)4.40284199
39plasma lipoprotein particle assembly (GO:0034377)4.38214096
40microtubule severing (GO:0051013)4.34424001
41* multicellular organismal reproductive process (GO:0048609)4.34347000
42left/right pattern formation (GO:0060972)4.33529349
43indole-containing compound catabolic process (GO:0042436)4.24004330
44indolalkylamine catabolic process (GO:0046218)4.24004330
45tryptophan catabolic process (GO:0006569)4.24004330
46regulation of cytokine secretion involved in immune response (GO:0002739)4.23087508
47reverse cholesterol transport (GO:0043691)4.19702230
48regulation of mesoderm development (GO:2000380)4.19259588
49meiosis I (GO:0007127)4.18528527
50phospholipid homeostasis (GO:0055091)4.15940830
51protein localization to cilium (GO:0061512)4.15342298
52glycerol ether metabolic process (GO:0006662)4.02584192
53anterior/posterior axis specification, embryo (GO:0008595)4.01093607
54meiotic cell cycle (GO:0051321)3.91839729
55negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.89619847
56single strand break repair (GO:0000012)3.79918716
57protein-lipid complex assembly (GO:0065005)3.76601066
58monoubiquitinated protein deubiquitination (GO:0035520)3.74018038
59ether metabolic process (GO:0018904)3.73062991
60centriole assembly (GO:0098534)3.65319118
61intraciliary transport (GO:0042073)3.62779062
62tryptophan metabolic process (GO:0006568)3.62281027
63genitalia morphogenesis (GO:0035112)3.59395298
64negative regulation of keratinocyte proliferation (GO:0010839)3.58151008
65triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.57581471
66negative regulation of activin receptor signaling pathway (GO:0032926)3.56484341
67multicellular organismal development (GO:0007275)3.55474126
68synapsis (GO:0007129)3.54436695
69cellular ketone body metabolic process (GO:0046950)3.53161623
70cilium organization (GO:0044782)3.53094986
71protein K11-linked deubiquitination (GO:0035871)3.52534461
72axoneme assembly (GO:0035082)3.52390387
73cell migration involved in gastrulation (GO:0042074)3.52127437
74protein polyglutamylation (GO:0018095)3.48568031
75aromatic amino acid family catabolic process (GO:0009074)3.48293584
76negative regulation of lipase activity (GO:0060192)3.46476635
77signal transduction involved in regulation of gene expression (GO:0023019)3.46336106
78cholesterol efflux (GO:0033344)3.44532321
79somite rostral/caudal axis specification (GO:0032525)3.42522143
80cilium assembly (GO:0042384)3.41879539
81epoxygenase P450 pathway (GO:0019373)3.39933371
82drug catabolic process (GO:0042737)3.39850638
83S-adenosylmethionine metabolic process (GO:0046500)3.38755357
84endoderm formation (GO:0001706)3.37406274
85regulation of spindle checkpoint (GO:0090231)3.37344400
86exogenous drug catabolic process (GO:0042738)3.36430600
87DNA packaging (GO:0006323)3.35901262
88regulation of retinoic acid receptor signaling pathway (GO:0048385)3.31676518
89indolalkylamine metabolic process (GO:0006586)3.28868299
90omega-hydroxylase P450 pathway (GO:0097267)3.28092024
91chromosome condensation (GO:0030261)3.27911957
92very-low-density lipoprotein particle assembly (GO:0034379)3.27747482
93meiotic chromosome segregation (GO:0045132)3.27734577
94kynurenine metabolic process (GO:0070189)3.22604692
95lactate metabolic process (GO:0006089)3.22463816
96positive regulation of meiotic cell cycle (GO:0051446)3.21727809
97female gonad development (GO:0008585)3.21235477
98establishment of protein localization to Golgi (GO:0072600)3.21065193
99oxidative demethylation (GO:0070989)3.20280648
100protein-lipid complex remodeling (GO:0034368)3.18980159
101macromolecular complex remodeling (GO:0034367)3.18980159
102plasma lipoprotein particle remodeling (GO:0034369)3.18980159
103heme transport (GO:0015886)3.17949685
104L-ascorbic acid metabolic process (GO:0019852)3.15069112
105cellular component assembly involved in morphogenesis (GO:0010927)3.13450756
106microtubule polymerization or depolymerization (GO:0031109)3.13179428
107positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.10469939
108regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.10221986
109amine catabolic process (GO:0009310)3.08719038
110cellular biogenic amine catabolic process (GO:0042402)3.08719038
111cilium morphogenesis (GO:0060271)3.08150764
112histone exchange (GO:0043486)3.07331456
113resolution of meiotic recombination intermediates (GO:0000712)3.06510721
114meiotic cell cycle process (GO:1903046)3.06399736
115DNA synthesis involved in DNA repair (GO:0000731)3.03675065
116xenobiotic catabolic process (GO:0042178)3.01965513
117polyol catabolic process (GO:0046174)3.01732247
118microtubule-based movement (GO:0007018)2.99581008
119ketone body metabolic process (GO:1902224)2.97808509
120phosphatidylethanolamine biosynthetic process (GO:0006646)2.97013317
121triglyceride homeostasis (GO:0070328)2.96862845
122acylglycerol homeostasis (GO:0055090)2.96862845
123bile acid biosynthetic process (GO:0006699)2.96801573
124nucleoside diphosphate phosphorylation (GO:0006165)2.94740564
125embryonic axis specification (GO:0000578)2.94233903
126keratinocyte development (GO:0003334)2.92914988
127protein-chromophore linkage (GO:0018298)2.92653999
128positive regulation of meiosis (GO:0045836)2.89575732
129protein targeting to Golgi (GO:0000042)2.89276454
130fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.87189909
131regulation of female receptivity (GO:0045924)2.87163043
132plasma lipoprotein particle clearance (GO:0034381)2.87084575
133alditol metabolic process (GO:0019400)2.86840662
134DNA replication checkpoint (GO:0000076)2.85595176
135gene silencing by RNA (GO:0031047)2.84583794
136UDP-N-acetylglucosamine metabolic process (GO:0006047)2.83769729
137interferon-gamma secretion (GO:0072643)2.82934729
138regulation of acyl-CoA biosynthetic process (GO:0050812)2.81772877
139plasma lipoprotein particle organization (GO:0071827)2.81631093
140anterior/posterior axis specification (GO:0009948)2.81465176
141nucleus organization (GO:0006997)2.81456267
142phosphatidylethanolamine metabolic process (GO:0046337)2.81104157
143phosphatidylcholine biosynthetic process (GO:0006656)2.80501763
144negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.80353929
145reciprocal DNA recombination (GO:0035825)2.80323507
146reciprocal meiotic recombination (GO:0007131)2.80323507
147nodal signaling pathway (GO:0038092)2.79309439
148centriole replication (GO:0007099)2.77765925
149primitive streak formation (GO:0090009)2.76423744
150outflow tract septum morphogenesis (GO:0003148)2.75960499
151chaperone-mediated protein complex assembly (GO:0051131)2.75213006
152GTP biosynthetic process (GO:0006183)2.74987216
153left/right axis specification (GO:0070986)2.71654109
154RNA localization (GO:0006403)2.71199401
155sequestering of actin monomers (GO:0042989)2.68693721
156negative regulation of skeletal muscle tissue development (GO:0048642)2.63700540
157amino-acid betaine transport (GO:0015838)2.62605501
158carnitine transport (GO:0015879)2.62605501
159protein refolding (GO:0042026)2.56069859
160glycerol metabolic process (GO:0006071)2.55365335
161mitotic sister chromatid cohesion (GO:0007064)2.55332327
162carnitine transmembrane transport (GO:1902603)2.55317289
163regulation of meiosis I (GO:0060631)2.54684236
164calcium ion import (GO:0070509)2.52385510
165regulation of centriole replication (GO:0046599)2.51494587
166nuclear pore complex assembly (GO:0051292)2.45484714
167glycolytic process (GO:0006096)2.44561408
168negative regulation of organelle assembly (GO:1902116)2.43387054
169fusion of sperm to egg plasma membrane (GO:0007342)13.3451732
170sperm motility (GO:0030317)12.6506200
171cilium or flagellum-dependent cell motility (GO:0001539)12.5413776
172cell wall macromolecule catabolic process (GO:0016998)11.6580010
173cell wall macromolecule metabolic process (GO:0044036)11.6580010
174multicellular organism reproduction (GO:0032504)11.2642771
175acrosome reaction (GO:0007340)11.1552116
176sperm-egg recognition (GO:0035036)10.8885655
177acrosome assembly (GO:0001675)10.7912468
178axonemal dynein complex assembly (GO:0070286)10.6191835
179epithelial cilium movement (GO:0003351)10.4101887
180plasma membrane fusion (GO:0045026)10.1546579

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.06095890
2EZH2_22144423_ChIP-Seq_EOC_Human4.68062808
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.22899005
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.50308226
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.25236942
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.99613253
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.76324168
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.61365761
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.56391742
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.55368568
11* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.52728372
12P300_19829295_ChIP-Seq_ESCs_Human2.40165267
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.25360521
14BCAT_22108803_ChIP-Seq_LS180_Human2.17747433
15VDR_22108803_ChIP-Seq_LS180_Human2.14233243
16SMAD3_21741376_ChIP-Seq_HESCs_Human2.06151390
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05046448
18EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.00095310
19PCGF2_27294783_Chip-Seq_NPCs_Mouse1.99597695
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98135985
21CBX2_27304074_Chip-Seq_ESCs_Mouse1.96675763
22IGF1R_20145208_ChIP-Seq_DFB_Human1.96411411
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94390335
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.94145934
25SMAD3_21741376_ChIP-Seq_EPCs_Human1.93892864
26* NFE2_27457419_Chip-Seq_LIVER_Mouse1.91885298
27EWS_26573619_Chip-Seq_HEK293_Human1.91207251
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88133672
29* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.87708067
30SMAD4_21741376_ChIP-Seq_EPCs_Human1.84220346
31ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.82137262
32SMAD4_21741376_ChIP-Seq_HESCs_Human1.80920932
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77707711
34TAL1_26923725_Chip-Seq_HPCs_Mouse1.74784293
35KLF5_20875108_ChIP-Seq_MESCs_Mouse1.73561791
36KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.73279486
37* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.72332290
38GATA1_26923725_Chip-Seq_HPCs_Mouse1.72293493
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.71856001
40KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.71856001
41KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.71856001
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68974321
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.66083424
44STAT1_17558387_ChIP-Seq_HELA_Human1.64462894
45ZNF274_21170338_ChIP-Seq_K562_Hela1.63105090
46NANOG_19829295_ChIP-Seq_ESCs_Human1.61956959
47SOX2_19829295_ChIP-Seq_ESCs_Human1.61956959
48KAP1_22055183_ChIP-Seq_ESCs_Mouse1.59931924
49* NANOG_18555785_Chip-Seq_ESCs_Mouse1.58038088
50ELK4_26923725_Chip-Seq_MESODERM_Mouse1.56206309
51* TCF4_22108803_ChIP-Seq_LS180_Human1.55175406
52RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.54148291
53* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53911387
54* KDM2B_26808549_Chip-Seq_REH_Human1.53474707
55* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.52711830
56KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.52273805
57AR_25329375_ChIP-Seq_VCAP_Human1.51833213
58MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.51548416
59* EZH2_27294783_Chip-Seq_NPCs_Mouse1.50111015
60TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.49682878
61* P53_22387025_ChIP-Seq_ESCs_Mouse1.48977367
62CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.48184966
63STAT3_23295773_ChIP-Seq_U87_Human1.48183523
64CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.47273913
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44445041
66CBP_20019798_ChIP-Seq_JUKART_Human1.44445041
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44256982
68REST_21632747_ChIP-Seq_MESCs_Mouse1.43371351
69WDR5_24793694_ChIP-Seq_LNCAP_Human1.41296868
70* OCT4_18555785_Chip-Seq_ESCs_Mouse1.41265480
71* CRX_20693478_ChIP-Seq_RETINA_Mouse1.38729485
72RNF2_27304074_Chip-Seq_NSC_Mouse1.37361318
73* CMYC_18555785_Chip-Seq_ESCs_Mouse1.37132134
74CDX2_22108803_ChIP-Seq_LS180_Human1.36901466
75* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.36063865
76FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36046022
77* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.36045928
78* STAT3_18555785_Chip-Seq_ESCs_Mouse1.35772077
79RUNX2_22187159_ChIP-Seq_PCA_Human1.35252839
80* P300_18555785_Chip-Seq_ESCs_Mouse1.34842306
81* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.34751296
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33455125
83TAF15_26573619_Chip-Seq_HEK293_Human1.32383993
84* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31353689
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30922620
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30922620
87GBX2_23144817_ChIP-Seq_PC3_Human1.30611958
88* E2F1_18555785_Chip-Seq_ESCs_Mouse1.28928314
89AUTS2_25519132_ChIP-Seq_293T-REX_Human1.28910832
90* KLF4_18555785_Chip-Seq_ESCs_Mouse1.27290626
91* LXR_22158963_ChIP-Seq_LIVER_Mouse1.26723410
92GATA4_25053715_ChIP-Seq_YYC3_Human1.26329245
93* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25668673
94* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.24729721
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23805649
96FOXM1_26456572_ChIP-Seq_MCF-7_Human1.23398128
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23177631
98* PU1_27457419_Chip-Seq_LIVER_Mouse1.23141197
99* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.22881766
100* SOX2_18555785_Chip-Seq_ESCs_Mouse1.22643705
101FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21920240
102FOXA1_25329375_ChIP-Seq_VCAP_Human1.21920240
103AR_21909140_ChIP-Seq_LNCAP_Human1.21740129
104TP53_22573176_ChIP-Seq_HFKS_Human1.21188850
105GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.20695452
106MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20321858
107FUS_26573619_Chip-Seq_HEK293_Human1.19769013
108GF1_26923725_Chip-Seq_HPCs_Mouse1.19311500
109* NMYC_18555785_Chip-Seq_ESCs_Mouse1.18751544
110CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18241416
111CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.17685503
112GABP_17652178_ChIP-ChIP_JURKAT_Human1.16603270
113HOXB7_26014856_ChIP-Seq_BT474_Human1.16341811
114NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16320297
115* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.16153945
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16010056
117PRDM14_20953172_ChIP-Seq_ESCs_Human1.15635265
118* PHF8_20622853_ChIP-Seq_HELA_Human1.15346399
119SOX2_22085726_ChIP-Seq_NPCs_Mouse1.15330321
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15082283
121FLI1_21867929_ChIP-Seq_TH2_Mouse1.14174134
122GATA3_21867929_ChIP-Seq_CD8_Mouse1.14025434
123* ETV1_20927104_ChIP-Seq_GIST48_Human1.13804945
124* ZFX_18555785_Chip-Seq_ESCs_Mouse1.13198561
125* CTCF_18555785_Chip-Seq_ESCs_Mouse1.11860618
126SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11431490
127SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10624563
128* RBPJ_21746931_ChIP-Seq_IB4_Human1.10229019
129OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10152098
130FOXH1_21741376_ChIP-Seq_EPCs_Human1.09859099
131ER_23166858_ChIP-Seq_MCF-7_Human1.09017543
132SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.08822151
133KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.08646915
134TCF4_18268006_ChIP-ChIP_LS174T_Human1.08532960
135* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.07856325
136RUNX1_26923725_Chip-Seq_HPCs_Mouse1.07771252
137GATA3_21867929_ChIP-Seq_TH1_Mouse1.07754619
138TP53_18474530_ChIP-ChIP_U2OS_Human1.07195492
139TCF4_23295773_ChIP-Seq_U87_Human1.06492812
140SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05950578
141SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05943562
142SMAD4_21799915_ChIP-Seq_A2780_Human1.05747340
143CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05188357
144GATA3_21878914_ChIP-Seq_MCF-7_Human1.04879100
145FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04567874
146PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03910960
147EOMES_21245162_ChIP-Seq_HESCs_Human1.03795564
148* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.03407375
149POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02994681
150TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01612400
151ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01052912
152UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00046159
153CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99743347
154SMAD3_21741376_ChIP-Seq_ESCs_Human0.99252924
155CBP_21632823_ChIP-Seq_H3396_Human0.99113024
156ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98842413
157SOX9_26525672_Chip-Seq_HEART_Mouse0.98542825
158SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98184699
159GF1B_26923725_Chip-Seq_HPCs_Mouse0.97994690
160* NFYB_21822215_ChIP-Seq_K562_Human0.97062790
161* TBL1_22424771_ChIP-Seq_293T_Human0.96073996
162AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95263972
163LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.95096812
164CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94017307
165RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93644117
166* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93139288
167PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92378339

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.85121570
2* MP0001929_abnormal_gametogenesis5.24816963
3MP0008877_abnormal_DNA_methylation4.71429557
4MP0003890_abnormal_embryonic-extraembry4.30139533
5MP0003195_calcinosis4.22061470
6MP0002210_abnormal_sex_determination3.65417472
7MP0002139_abnormal_hepatobiliary_system3.59363095
8* MP0002161_abnormal_fertility/fecundity3.09783891
9MP0001145_abnormal_male_reproductive2.91921618
10MP0002138_abnormal_hepatobiliary_system2.86822644
11MP0002254_reproductive_system_inflammat2.81127184
12MP0005670_abnormal_white_adipose2.76955587
13MP0002653_abnormal_ependyma_morphology2.67203880
14MP0000653_abnormal_sex_gland2.58983512
15MP0006054_spinal_hemorrhage2.48247612
16MP0003718_maternal_effect2.39907843
17MP0003136_yellow_coat_color2.39144732
18MP0005365_abnormal_bile_salt2.30776827
19MP0005085_abnormal_gallbladder_physiolo2.23627040
20MP0009840_abnormal_foam_cell2.19824685
21MP0005367_renal/urinary_system_phenotyp2.13135349
22MP0000516_abnormal_urinary_system2.13135349
23MP0003119_abnormal_digestive_system2.12265273
24* MP0005410_abnormal_fertilization14.8030337
25MP0004264_abnormal_extraembryonic_tissu1.84954375
26MP0002160_abnormal_reproductive_system1.83685723
27MP0010329_abnormal_lipoprotein_level1.83614825
28MP0003191_abnormal_cellular_cholesterol1.82883438
29MP0004147_increased_porphyrin_level1.69757796
30MP0008872_abnormal_physiological_respon1.65065007
31MP0005360_urolithiasis1.62990990
32MP0008058_abnormal_DNA_repair1.62922196
33MP0001666_abnormal_nutrient_absorption1.50243266
34MP0002102_abnormal_ear_morphology1.47391056
35MP0003806_abnormal_nucleotide_metabolis1.46374304
36MP0000647_abnormal_sebaceous_gland1.46318508
37MP0003646_muscle_fatigue1.44961465
38MP0008995_early_reproductive_senescence1.44290415
39MP0008875_abnormal_xenobiotic_pharmacok1.44286600
40MP0003943_abnormal_hepatobiliary_system1.35465101
41MP0005623_abnormal_meninges_morphology1.34659976
42MP0001984_abnormal_olfaction1.34238611
43MP0003878_abnormal_ear_physiology1.33356753
44MP0005377_hearing/vestibular/ear_phenot1.33356753
45MP0005647_abnormal_sex_gland1.32537781
46MP0000372_irregular_coat_pigmentation1.32269202
47MP0003252_abnormal_bile_duct1.28882735
48MP0009046_muscle_twitch1.28176905
49MP0005395_other_phenotype1.26672495
50MP0005084_abnormal_gallbladder_morpholo1.25765369
51MP0004957_abnormal_blastocyst_morpholog1.25670266
52MP0000569_abnormal_digit_pigmentation1.25270925
53MP0001485_abnormal_pinna_reflex1.21430988
54MP0003937_abnormal_limbs/digits/tail_de1.21112553
55MP0000427_abnormal_hair_cycle1.19733788
56MP0010030_abnormal_orbit_morphology1.17654978
57MP0005332_abnormal_amino_acid1.16639222
58MP0002282_abnormal_trachea_morphology1.15147124
59MP0003693_abnormal_embryo_hatching1.11076344
60MP0005389_reproductive_system_phenotype1.10798451
61MP0009697_abnormal_copulation1.08992363
62MP0003787_abnormal_imprinting1.08854546
63MP0005646_abnormal_pituitary_gland1.08664341
64MP0005187_abnormal_penis_morphology1.07781791
65MP0002084_abnormal_developmental_patter1.05001204
66MP0009780_abnormal_chondrocyte_physiolo1.02520092
67MP0002127_abnormal_cardiovascular_syste1.01812390
68MP0009053_abnormal_anal_canal1.00306747
69MP0003186_abnormal_redox_activity0.99892494
70MP0008057_abnormal_DNA_replication0.98522471
71MP0001672_abnormal_embryogenesis/_devel0.97448028
72MP0005380_embryogenesis_phenotype0.97448028
73MP0010094_abnormal_chromosome_stability0.92880441
74MP0001986_abnormal_taste_sensitivity0.92489647
75MP0003567_abnormal_fetal_cardiomyocyte0.92099371
76MP0001765_abnormal_ion_homeostasis0.91713062
77MP0010678_abnormal_skin_adnexa0.86545855
78MP0003984_embryonic_growth_retardation0.86296049
79MP0002088_abnormal_embryonic_growth/wei0.85464089
80MP0003786_premature_aging0.84223542
81MP0004742_abnormal_vestibular_system0.82224331
82MP0002132_abnormal_respiratory_system0.81983260
83MP0001661_extended_life_span0.80302099
84MP0002736_abnormal_nociception_after0.78625582
85MP0005551_abnormal_eye_electrophysiolog0.77277630
86MP0004233_abnormal_muscle_weight0.72977297
87MP0004215_abnormal_myocardial_fiber0.72831373
88MP0000566_synostosis0.72704942
89MP0001697_abnormal_embryo_size0.72175634
90MP0005253_abnormal_eye_physiology0.71779936
91MP0006035_abnormal_mitochondrial_morpho0.71108159
92MP0008775_abnormal_heart_ventricle0.69941072
93MP0001324_abnormal_eye_pigmentation0.69410559
94MP0003879_abnormal_hair_cell0.68576590
95MP0005266_abnormal_metabolism0.68406418
96MP0003137_abnormal_impulse_conducting0.68030519
97MP0001348_abnormal_lacrimal_gland0.66096541
98MP0002277_abnormal_respiratory_mucosa0.65652017
99* MP0002118_abnormal_lipid_homeostasis0.63734507
100MP0003111_abnormal_nucleus_morphology0.63402274
101MP0001119_abnormal_female_reproductive0.62536838
102MP0002233_abnormal_nose_morphology0.61680113
103MP0000015_abnormal_ear_pigmentation0.61598277
104MP0000639_abnormal_adrenal_gland0.61465075
105MP0002086_abnormal_extraembryonic_tissu0.61190659
106MP0008004_abnormal_stomach_pH0.61139890
107MP0001764_abnormal_homeostasis0.58828680
108MP0008932_abnormal_embryonic_tissue0.58436155
109MP0002928_abnormal_bile_duct0.58198157
110MP0006292_abnormal_olfactory_placode0.57025988
111MP0006072_abnormal_retinal_apoptosis0.56819475
112MP0001188_hyperpigmentation0.56455264
113MP0003011_delayed_dark_adaptation0.53484306
114MP0008007_abnormal_cellular_replicative0.53214216
115MP0003699_abnormal_female_reproductive0.52994609
116MP0005171_absent_coat_pigmentation0.52655593
117MP0003115_abnormal_respiratory_system0.51817635
118MP0000383_abnormal_hair_follicle0.51650315
119MP0001293_anophthalmia0.50245139
120MP0005645_abnormal_hypothalamus_physiol0.49285899
121MP0001968_abnormal_touch/_nociception0.49240681
122MP0004134_abnormal_chest_morphology0.49067604
123MP0001486_abnormal_startle_reflex0.47378264
124MP0003950_abnormal_plasma_membrane0.46754284
125MP0009278_abnormal_bone_marrow0.46624409
126MP0005174_abnormal_tail_pigmentation0.46387585
127MP0005391_vision/eye_phenotype0.45081999
128MP0005423_abnormal_somatic_nervous0.44958256
129MP0002735_abnormal_chemical_nociception0.44192000
130MP0002876_abnormal_thyroid_physiology0.44164996
131MP0002163_abnormal_gland_morphology0.43389450
132MP0000678_abnormal_parathyroid_gland0.42992688
133MP0001963_abnormal_hearing_physiology0.42897552
134MP0004019_abnormal_vitamin_homeostasis0.42552925
135MP0002557_abnormal_social/conspecific_i0.42452649
136MP0000026_abnormal_inner_ear0.38159424
137MP0005636_abnormal_mineral_homeostasis0.37371869
138MP0001502_abnormal_circadian_rhythm0.36529315
139MP0001919_abnormal_reproductive_system0.35393058
140MP0002234_abnormal_pharynx_morphology0.34510696
141MP0002572_abnormal_emotion/affect_behav0.33764534
142MP0005397_hematopoietic_system_phenotyp0.30147160
143MP0001545_abnormal_hematopoietic_system0.30147160
144MP0004133_heterotaxia0.27828805
145MP0009115_abnormal_fat_cell0.27609860
146MP0003942_abnormal_urinary_system0.27550131
147MP0005379_endocrine/exocrine_gland_phen0.27539747
148MP0003936_abnormal_reproductive_system0.26715539
149MP0002067_abnormal_sensory_capabilities0.25979067
150MP0005451_abnormal_body_composition0.25382635
151MP0010386_abnormal_urinary_bladder0.25344831
152MP0005075_abnormal_melanosome_morpholog0.25277729
153MP0001270_distended_abdomen0.24946104
154MP0001440_abnormal_grooming_behavior0.24800695
155MP0005195_abnormal_posterior_eye0.24120959
156MP0006276_abnormal_autonomic_nervous0.23793344
157MP0009250_abnormal_appendicular_skeleto0.22731615
158MP0002109_abnormal_limb_morphology0.22038181
159MP0003183_abnormal_peptide_metabolism0.21883832
160MP0000358_abnormal_cell_content/0.21103603
161MP0004381_abnormal_hair_follicle0.20959213

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)8.98208397
2Abnormal respiratory motile cilium morphology (HP:0005938)8.98208397
3Abnormal respiratory motile cilium physiology (HP:0012261)8.95850755
4Abnormal ciliary motility (HP:0012262)7.42558934
5Rhinitis (HP:0012384)7.29015002
6Chronic bronchitis (HP:0004469)6.47408838
7Infertility (HP:0000789)5.73179484
8Nasal polyposis (HP:0100582)5.50147602
9Nephronophthisis (HP:0000090)4.53438584
10Abnormality of the nasal mucosa (HP:0000433)4.36906231
11Bronchiectasis (HP:0002110)4.30852831
12Hypoalphalipoproteinemia (HP:0003233)4.23991808
13Bronchitis (HP:0012387)3.97612092
14Hypolipoproteinemia (HP:0010981)3.96453980
15Spontaneous abortion (HP:0005268)3.82368409
16Abnormal pancreas size (HP:0012094)3.74072058
17Hypobetalipoproteinemia (HP:0003563)3.66101400
18Congenital malformation of the right heart (HP:0011723)3.65694981
19Double outlet right ventricle (HP:0001719)3.65694981
20Abnormality of the renal medulla (HP:0100957)3.56320673
21Abnormality of alanine metabolism (HP:0010916)3.55146712
22Hyperalaninemia (HP:0003348)3.55146712
23Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.55146712
24Male infertility (HP:0003251)3.49130729
25Proximal tubulopathy (HP:0000114)3.47251608
26Intestinal atresia (HP:0011100)3.44722680
27Tubulointerstitial nephritis (HP:0001970)3.42164417
28Osteomalacia (HP:0002749)3.38145376
29Recurrent sinusitis (HP:0011108)3.34374725
30Abnormal spermatogenesis (HP:0008669)3.23995788
31Abnormality of the parathyroid morphology (HP:0011766)3.19413962
32Intrahepatic cholestasis (HP:0001406)3.18978659
33Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.12057638
34Medial flaring of the eyebrow (HP:0010747)3.06770457
35Recurrent otitis media (HP:0000403)3.01989161
36Abnormal umbilical cord blood vessels (HP:0011403)2.94727294
37Single umbilical artery (HP:0001195)2.94727294
38Abnormality of the fetal cardiovascular system (HP:0010948)2.94727294
39Attenuation of retinal blood vessels (HP:0007843)2.93743453
40Anal stenosis (HP:0002025)2.93601858
41Gonadal dysgenesis (HP:0000133)2.82863522
42Abnormality of monocarboxylic acid metabolism (HP:0010996)2.78100046
43Abnormality of midbrain morphology (HP:0002418)2.74691989
44Molar tooth sign on MRI (HP:0002419)2.74691989
45Oligodactyly (hands) (HP:0001180)2.69636303
46Severe visual impairment (HP:0001141)2.55004897
47Tubulointerstitial abnormality (HP:0001969)2.53888938
48Tubular atrophy (HP:0000092)2.53351803
49Prolonged partial thromboplastin time (HP:0003645)2.49829124
50Short middle phalanx of the 5th finger (HP:0004220)2.49791750
51Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.45912379
52Hypophosphatemic rickets (HP:0004912)2.45009843
53Impulsivity (HP:0100710)2.44702158
54Cerebellar dysplasia (HP:0007033)2.41916049
55Gonadotropin excess (HP:0000837)2.35033735
56Azoospermia (HP:0000027)2.34726892
57Absent radius (HP:0003974)2.34497829
58Recurrent bronchitis (HP:0002837)2.31080928
59Postaxial foot polydactyly (HP:0001830)2.25493909
60Retinal atrophy (HP:0001105)2.24074054
61Enlarged kidneys (HP:0000105)2.21594923
62Abnormality of the renal cortex (HP:0011035)2.20850206
63Conjugated hyperbilirubinemia (HP:0002908)2.19896357
64Abnormality of macular pigmentation (HP:0008002)2.18309212
65Abnormality of aromatic amino acid family metabolism (HP:0004338)2.17621164
66Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.17244070
67Disproportionate short-trunk short stature (HP:0003521)2.17172949
68Absent forearm bone (HP:0003953)2.16061187
69Aplasia involving forearm bones (HP:0009822)2.16061187
70Abnormality of urine glucose concentration (HP:0011016)2.14699325
71Glycosuria (HP:0003076)2.14699325
72Periauricular skin pits (HP:0100277)2.13213428
73Preauricular pit (HP:0004467)2.13213428
74Bony spicule pigmentary retinopathy (HP:0007737)2.13066698
75Abnormal biliary tract physiology (HP:0012439)2.12556013
76Bile duct proliferation (HP:0001408)2.12556013
77Bifid tongue (HP:0010297)2.12524237
78Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.12517470
79Stage 5 chronic kidney disease (HP:0003774)2.12480377
80Abnormality of serum amino acid levels (HP:0003112)2.12402460
81Rectal fistula (HP:0100590)2.12228628
82Rectovaginal fistula (HP:0000143)2.12228628
83Amelogenesis imperfecta (HP:0000705)2.11467009
84Aplasia/Hypoplasia involving the musculature (HP:0001460)2.10864664
85Hyperglycinemia (HP:0002154)2.10479979
86Congenital hepatic fibrosis (HP:0002612)2.08804082
87Abnormality of dental color (HP:0011073)2.08420216
88Chronic hepatic failure (HP:0100626)2.07854071
89Abnormal drinking behavior (HP:0030082)2.04827715
90Polydipsia (HP:0001959)2.04827715
91Pancreatic islet-cell hyperplasia (HP:0004510)2.03756910
92Hyperlipoproteinemia (HP:0010980)2.03467483
93Dynein arm defect of respiratory motile cilia (HP:0012255)12.8345765
94Absent/shortened dynein arms (HP:0200106)12.8345765
95Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.5698207
96Fibular hypoplasia (HP:0003038)1.98765740
97Abnormality of methionine metabolism (HP:0010901)1.97421463
98Vaginal fistula (HP:0004320)1.96838316
99Nausea (HP:0002018)1.94399619
100Renal dysplasia (HP:0000110)1.94160013
101Decreased central vision (HP:0007663)1.92764803
102Abnormality of the phalanges of the 5th finger (HP:0004213)1.90667599
103Fair hair (HP:0002286)1.90119837
104Abnormality of permanent molar morphology (HP:0011071)1.89776076
105Abnormality of the dental root (HP:0006486)1.89776076
106Taurodontia (HP:0000679)1.89776076
107Concave nail (HP:0001598)1.89684790
108Dyschromatopsia (HP:0007641)1.89589627
109Pancreatic fibrosis (HP:0100732)1.88082988
110Abnormal connection of the cardiac segments (HP:0011545)1.87278567
111Abnormal ventriculo-arterial connection (HP:0011563)1.87278567
112Transposition of the great arteries (HP:0001669)1.87278567
113Abnormality of molar (HP:0011077)1.84962696
114Abnormality of molar morphology (HP:0011070)1.84962696
115Asplenia (HP:0001746)1.84250947
116True hermaphroditism (HP:0010459)1.82937727
117Anal atresia (HP:0002023)1.82314434
118Congenital primary aphakia (HP:0007707)1.81851736
119Abnormality of the common coagulation pathway (HP:0010990)1.81649225
120Progressive inability to walk (HP:0002505)1.81509345
121Rickets (HP:0002748)1.80206593
122Labial hypoplasia (HP:0000066)1.79648985
123Abnormality of aspartate family amino acid metabolism (HP:0010899)1.78522474
124Gait imbalance (HP:0002141)1.78433045
125Abnormality of serine family amino acid metabolism (HP:0010894)1.77923833
126Abnormality of glycine metabolism (HP:0010895)1.77923833
127Abnormality of the umbilical cord (HP:0010881)1.77540143
128Bell-shaped thorax (HP:0001591)1.77420686
129Chronic sinusitis (HP:0011109)1.77020376
130Abnormality of pyrimidine metabolism (HP:0004353)1.77012801
131Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76699450
132Postaxial hand polydactyly (HP:0001162)1.75670525
133Aplasia/Hypoplasia of the spleen (HP:0010451)1.75607701
134Nephrogenic diabetes insipidus (HP:0009806)1.75340939
135Abnormality of the dental pulp (HP:0006479)1.75102027
136Cone-rod dystrophy (HP:0000548)1.72620220
137Anophthalmia (HP:0000528)1.72418150
138Abnormal auditory evoked potentials (HP:0006958)1.72376306
139Tubulointerstitial fibrosis (HP:0005576)1.72055329
140Hypoplasia of the capital femoral epiphysis (HP:0003090)1.71663356
141Abnormality of renal excretion (HP:0011036)1.71417306
142Hypomagnesemia (HP:0002917)1.71199023
143Fat malabsorption (HP:0002630)1.71063070
144Popliteal pterygium (HP:0009756)1.70646719
145Abnormality of the lower motor neuron (HP:0002366)1.70610719
146Median cleft lip (HP:0000161)1.69534810
147Respiratory difficulties (HP:0002880)1.69380512
148Myelomeningocele (HP:0002475)1.69220140
149Hyperglycinuria (HP:0003108)1.68829369
150Oculomotor apraxia (HP:0000657)1.67858006
151Type II lissencephaly (HP:0007260)1.67099942
152Cystic liver disease (HP:0006706)1.66670838
153Abnormality of the duodenum (HP:0002246)1.66218020
154Intestinal fistula (HP:0100819)1.66111882
155Facial cleft (HP:0002006)1.63609538
156Impaired proprioception (HP:0010831)1.63320219
157Aplasia/Hypoplasia of the lens (HP:0008063)1.61207571
158Choroideremia (HP:0001139)1.59955346
159Supernumerary spleens (HP:0009799)1.56519658
160Aplasia/Hypoplasia of the tongue (HP:0010295)1.56168904
161Spastic tetraparesis (HP:0001285)1.54736641
162Nephropathy (HP:0000112)1.53866321
163Absent frontal sinuses (HP:0002688)1.50335786
164Abnormality of dentin (HP:0010299)1.49749591
165Ectopic kidney (HP:0000086)1.47341952
166Short thorax (HP:0010306)1.47203146
167Poor coordination (HP:0002370)1.44088928
168Chromosomal breakage induced by crosslinking agents (HP:0003221)1.43391781
169Short ribs (HP:0000773)1.42483594
170Hypoplasia of dental enamel (HP:0006297)1.40651550
171Absent epiphyses (HP:0010577)1.39506737
172Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.39506737
173Absent eyebrow (HP:0002223)1.39166911
174Retrobulbar optic neuritis (HP:0100654)1.39042591
175Optic neuritis (HP:0100653)1.39042591
176Aplasia/Hypoplasia of the uvula (HP:0010293)1.38650715
177Heterotopia (HP:0002282)1.38543886
178Pancreatic cysts (HP:0001737)1.38326847
179Abnormal gallbladder physiology (HP:0012438)1.35305232
180Cholecystitis (HP:0001082)1.35305232
181Genital tract atresia (HP:0001827)1.34393733
182Microglossia (HP:0000171)1.34103339
183Vaginal atresia (HP:0000148)1.33087577
184Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.33044608
185Abnormal urine output (HP:0012590)1.32935288
186Optic nerve hypoplasia (HP:0000609)1.31630303
187Hyperphosphatemia (HP:0002905)1.30406636
188Amyotrophic lateral sclerosis (HP:0007354)1.29617453
189J-shaped sella turcica (HP:0002680)1.28685690
190Astigmatism (HP:0000483)1.28551544

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.44686672
2PDK48.44686672
3PDK25.55003327
4ACVR1B4.93399282
5TESK14.81607848
6FRK4.31311995
7PRKD34.22680345
8ICK3.44157834
9PBK3.41686791
10OXSR13.05997347
11EIF2AK32.41371365
12ERBB42.36340940
13MST42.29714140
14MKNK22.11731932
15PTK2B2.00419881
16TRIM281.91546179
17WNK41.85952385
18STK391.80706262
19PNCK1.80087657
20NUAK11.73823833
21STK381.51924000
22MKNK11.42279756
23NEK21.41918741
24TGFBR11.39481537
25STK101.31711413
26EIF2AK11.24384046
27BRD41.16108230
28IRAK11.15654518
29FLT31.14283158
30CASK1.12992839
31MAPK151.10715573
32BMPR1B1.10276502
33STK38L1.06742650
34WNK10.99920653
35SIK30.99475241
36MELK0.92013196
37PIK3CG0.90024710
38CDK190.84066755
39MAP2K60.83939424
40STK30.83258125
41LATS20.82625668
42ERBB30.79373839
43DYRK1B0.78503091
44CCNB10.78035252
45PLK40.77532354
46PDK10.76420720
47IRAK20.76354571
48PRKAA20.75484363
49TTK0.74071477
50ADRBK10.73003804
51LMTK20.70986116
52ZAK0.70635688
53MAP3K120.70223367
54NEK60.68958978
55PINK10.68271699
56NTRK20.67509538
57CHEK20.66453055
58PASK0.65131584
59CAMK1G0.63151221
60CDK30.59224494
61PLK30.58997305
62ADRBK20.58380642
63DYRK30.58033926
64ATR0.52873156
65MUSK0.51671767
66KIT0.50591351
67NLK0.48673557
68MAP2K70.47307611
69TNIK0.47106727
70YES10.47038492
71PRKCE0.46699371
72EPHA40.46323398
73TXK0.45198415
74AKT30.44201629
75MET0.43807727
76ROCK10.43553849
77BRAF0.43133496
78CHEK10.43109063
79TYRO30.42725868
80SGK20.41389329
81ATM0.40489744
82MAP3K80.40136749
83LATS10.38904581
84RAF10.38452102
85PRKCI0.37844711
86RIPK40.36813896
87PRKCG0.36715120
88CDC70.36495886
89EIF2AK20.36293090
90MATK0.35535837
91PIK3CA0.35519540
92STK40.34563947
93DMPK0.34485262
94RPS6KB10.34424107
95CLK10.31069895
96PRKG20.30738113
97DAPK20.29605611
98MAP3K130.29116324
99PRKAA10.28899895
100PLK10.28601709
101MARK30.28021170
102PRKACB0.27964776
103CDK70.27128944
104STK160.26559411
105TNK20.25941508
106CDK120.25553871
107ERBB20.25415789
108CSNK1E0.24662051
109NEK10.24655259
110MAP2K10.24170675
111MARK20.22935497
112WNK30.22632240
113TLK10.22211933
114FER0.21514044
115EPHA20.21269806
116IGF1R0.19495613
117PDPK10.19161202
118PRKCQ0.18810951
119PRKG10.17872994
120PKN10.17133944
121BCR0.16993360
122PKN20.16700225
123SGK2230.16514886
124SGK4940.16514886
125BRSK10.15125748
126BRSK20.14573290
127DDR20.14561412
128MAP3K140.14257595
129PLK20.14103394
130MAP3K40.14034637
131PAK10.12663979
132CSNK2A10.12048829
133SRPK10.12000016
134CAMK2A0.11878814
135CSNK1D0.11150284
136GRK10.11098659
137INSRR0.10908285
138BMPR20.09869502
139OBSCN0.09423435
140GSK3B0.09221768
141MAPK130.09131601
142GRK70.08940572
143SGK30.07669137
144CAMK10.07040219
145SIK20.05888607
146WEE10.05368439
147PRKACA0.05233749
148MAPKAPK50.05169492
149PRKCA0.05119366
150PRKCZ0.05078291
151TEC0.04478958
152CDK10.04466005
153MTOR0.03668407
154MAPK80.03618452
155NTRK30.03326560
156PRKCB0.03165774

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.96575992
2Vitamin B6 metabolism_Homo sapiens_hsa007503.88528706
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.56269083
4Basal transcription factors_Homo sapiens_hsa030223.40514827
5Primary bile acid biosynthesis_Homo sapiens_hsa001203.16897490
6Fanconi anemia pathway_Homo sapiens_hsa034603.10980179
7Pyruvate metabolism_Homo sapiens_hsa006203.00325628
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.84529002
9Caffeine metabolism_Homo sapiens_hsa002322.76110355
10Linoleic acid metabolism_Homo sapiens_hsa005912.70741325
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.63007701
12Butanoate metabolism_Homo sapiens_hsa006502.57172250
13Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.57039844
14Propanoate metabolism_Homo sapiens_hsa006402.55944648
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37925245
16Glucagon signaling pathway_Homo sapiens_hsa049222.24910971
17Dorso-ventral axis formation_Homo sapiens_hsa043202.15403119
18Tryptophan metabolism_Homo sapiens_hsa003802.13713409
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.05792083
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.88114512
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.83643855
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.80527786
23Selenocompound metabolism_Homo sapiens_hsa004501.78576603
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.72930228
25Complement and coagulation cascades_Homo sapiens_hsa046101.72274328
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.68812034
27Glycerolipid metabolism_Homo sapiens_hsa005611.68710689
28Carbohydrate digestion and absorption_Homo sapiens_hsa049731.65818507
29Mineral absorption_Homo sapiens_hsa049781.65526667
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.65385839
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.61674489
32Amphetamine addiction_Homo sapiens_hsa050311.58835032
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.54331370
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.52883811
35Peroxisome_Homo sapiens_hsa041461.52306129
36beta-Alanine metabolism_Homo sapiens_hsa004101.50624867
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.50330292
38Pentose phosphate pathway_Homo sapiens_hsa000301.47133383
39Steroid biosynthesis_Homo sapiens_hsa001001.45303565
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.44983655
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43889203
42One carbon pool by folate_Homo sapiens_hsa006701.41047992
43Ether lipid metabolism_Homo sapiens_hsa005651.40076817
44Oocyte meiosis_Homo sapiens_hsa041141.35662157
45Fructose and mannose metabolism_Homo sapiens_hsa000511.34436553
46Huntingtons disease_Homo sapiens_hsa050161.34355807
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34345071
48Nitrogen metabolism_Homo sapiens_hsa009101.29910977
49Arginine biosynthesis_Homo sapiens_hsa002201.29171754
50Pentose and glucuronate interconversions_Homo sapiens_hsa000401.25217696
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23778371
52PPAR signaling pathway_Homo sapiens_hsa033201.21848449
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17731420
54mRNA surveillance pathway_Homo sapiens_hsa030151.17685905
55Drug metabolism - other enzymes_Homo sapiens_hsa009831.17340053
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15975410
57Renin secretion_Homo sapiens_hsa049241.15056340
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13327446
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13083989
60Arachidonic acid metabolism_Homo sapiens_hsa005901.11267738
61* Purine metabolism_Homo sapiens_hsa002301.07660444
62Calcium signaling pathway_Homo sapiens_hsa040201.07628279
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06646668
64Collecting duct acid secretion_Homo sapiens_hsa049661.05363503
65ABC transporters_Homo sapiens_hsa020101.02531946
66Arginine and proline metabolism_Homo sapiens_hsa003301.02422474
67Taste transduction_Homo sapiens_hsa047421.01562833
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00585419
69Hedgehog signaling pathway_Homo sapiens_hsa043400.98562253
70Fatty acid elongation_Homo sapiens_hsa000620.98283114
71Insulin secretion_Homo sapiens_hsa049110.94816907
72TGF-beta signaling pathway_Homo sapiens_hsa043500.94232290
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91650345
74Homologous recombination_Homo sapiens_hsa034400.91345160
75Cardiac muscle contraction_Homo sapiens_hsa042600.89783610
76Nicotine addiction_Homo sapiens_hsa050330.89368320
77Phototransduction_Homo sapiens_hsa047440.89320437
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85344886
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83343660
80Inositol phosphate metabolism_Homo sapiens_hsa005620.80940479
81RNA transport_Homo sapiens_hsa030130.80817598
82Histidine metabolism_Homo sapiens_hsa003400.80599728
83Tyrosine metabolism_Homo sapiens_hsa003500.80414821
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76580664
85Phenylalanine metabolism_Homo sapiens_hsa003600.75075123
86Sphingolipid metabolism_Homo sapiens_hsa006000.73794633
87Antigen processing and presentation_Homo sapiens_hsa046120.73769791
88Fatty acid metabolism_Homo sapiens_hsa012120.73731122
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73611614
90Sulfur metabolism_Homo sapiens_hsa009200.69715128
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67813629
92Circadian rhythm_Homo sapiens_hsa047100.67295919
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67159812
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66470303
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.64564257
96Non-homologous end-joining_Homo sapiens_hsa034500.63596615
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61024369
98Lysine degradation_Homo sapiens_hsa003100.60326723
99Vitamin digestion and absorption_Homo sapiens_hsa049770.58405700
100Proteasome_Homo sapiens_hsa030500.57413455
101Legionellosis_Homo sapiens_hsa051340.57170951
102Chemical carcinogenesis_Homo sapiens_hsa052040.56628301
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.55651398
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55334160
105Carbon metabolism_Homo sapiens_hsa012000.53439075
106Glutathione metabolism_Homo sapiens_hsa004800.53369691
107Nucleotide excision repair_Homo sapiens_hsa034200.52760636
108Fatty acid degradation_Homo sapiens_hsa000710.52269642
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52125700
110Synaptic vesicle cycle_Homo sapiens_hsa047210.51377506
111Protein export_Homo sapiens_hsa030600.50875972
112Basal cell carcinoma_Homo sapiens_hsa052170.49971031
113Pyrimidine metabolism_Homo sapiens_hsa002400.48421790
114Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48166009
115Morphine addiction_Homo sapiens_hsa050320.48009752
116Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47899993
117Fat digestion and absorption_Homo sapiens_hsa049750.47332351
118Mismatch repair_Homo sapiens_hsa034300.46746830
119Retinol metabolism_Homo sapiens_hsa008300.45736534
120Metabolic pathways_Homo sapiens_hsa011000.45367643
121Protein digestion and absorption_Homo sapiens_hsa049740.45138462
122Long-term potentiation_Homo sapiens_hsa047200.44972649
123Bile secretion_Homo sapiens_hsa049760.44678649
124Sulfur relay system_Homo sapiens_hsa041220.44465527
125Systemic lupus erythematosus_Homo sapiens_hsa053220.42558330
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.42366098
127RNA degradation_Homo sapiens_hsa030180.39788334
128Autoimmune thyroid disease_Homo sapiens_hsa053200.39033794
129Starch and sucrose metabolism_Homo sapiens_hsa005000.38293698
130Estrogen signaling pathway_Homo sapiens_hsa049150.37972722
131Salivary secretion_Homo sapiens_hsa049700.36048987
132Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.35095417
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34506608
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.33786816
135Measles_Homo sapiens_hsa051620.33782113
136Wnt signaling pathway_Homo sapiens_hsa043100.33598223
137N-Glycan biosynthesis_Homo sapiens_hsa005100.32691716
138Cell cycle_Homo sapiens_hsa041100.31641963
139Biosynthesis of amino acids_Homo sapiens_hsa012300.30302116
140Rheumatoid arthritis_Homo sapiens_hsa053230.29819504
141Cocaine addiction_Homo sapiens_hsa050300.29147628
142Glutamatergic synapse_Homo sapiens_hsa047240.29036528
143African trypanosomiasis_Homo sapiens_hsa051430.28570050
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28533620
145Influenza A_Homo sapiens_hsa051640.28333263
146RNA polymerase_Homo sapiens_hsa030200.28140267
147Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26694038
148Olfactory transduction_Homo sapiens_hsa047400.26387615
149Thyroid hormone synthesis_Homo sapiens_hsa049180.24380213
150Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.23106757
151Renin-angiotensin system_Homo sapiens_hsa046140.22360504
152Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22053035
153Base excision repair_Homo sapiens_hsa034100.21837130
154Allograft rejection_Homo sapiens_hsa053300.21539365
155Pancreatic secretion_Homo sapiens_hsa049720.19216172

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