ADCY6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the adenylyl cyclase family of proteins, which are required for the synthesis of cyclic AMP. All members of this family have an intracellular N-terminus, a tandem repeat of six transmembrane domains separated by a cytoplasmic loop, and a C-terminal cytoplasmic domain. The two cytoplasmic regions bind ATP and form the catalytic core of the protein. Adenylyl cyclases are important effectors of transmembrane signaling pathways and are regulated by the activity of G protein coupled receptor signaling. This protein belongs to a small subclass of adenylyl cyclase proteins that are functionally related and are inhibited by protein kinase A, calcium ions and nitric oxide. A mutation in this gene is associated with arthrogryposis multiplex congenita. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)5.47814950
2cardiac myofibril assembly (GO:0055003)5.41548257
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.68489043
4myofibril assembly (GO:0030239)4.57318045
5bundle of His cell to Purkinje myocyte communication (GO:0086069)4.54080491
6carnitine shuttle (GO:0006853)4.52450880
7negative regulation of potassium ion transmembrane transport (GO:1901380)4.46525702
8plasma membrane repair (GO:0001778)4.28718341
9ventricular cardiac muscle cell action potential (GO:0086005)4.17513465
10tricarboxylic acid cycle (GO:0006099)4.12821244
11fatty acid transmembrane transport (GO:1902001)4.11468648
12cardiac muscle contraction (GO:0060048)3.98660708
13regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.98490442
14actomyosin structure organization (GO:0031032)3.86326506
15cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.86153272
16cardiac muscle cell development (GO:0055013)3.80513994
17positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.72699008
18cardiac cell development (GO:0055006)3.64774970
19cell communication involved in cardiac conduction (GO:0086065)3.62086432
20muscle filament sliding (GO:0030049)3.58468319
21actin-myosin filament sliding (GO:0033275)3.58468319
22regulation of actin filament-based movement (GO:1903115)3.57058779
23regulation of fatty acid oxidation (GO:0046320)3.56223940
24regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.50372233
25adult heart development (GO:0007512)3.49203076
26carnitine transmembrane transport (GO:1902603)3.48639442
27heart trabecula formation (GO:0060347)3.47811793
282-oxoglutarate metabolic process (GO:0006103)3.47679917
29regulation of sequestering of triglyceride (GO:0010889)3.46964425
30regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.46948835
31cardiac muscle hypertrophy (GO:0003300)3.41125137
32regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.40894822
33tricarboxylic acid metabolic process (GO:0072350)3.35046243
34amino-acid betaine transport (GO:0015838)3.34770285
35carnitine transport (GO:0015879)3.34770285
36planar cell polarity pathway involved in neural tube closure (GO:0090179)3.33990747
37cell communication by electrical coupling (GO:0010644)3.33914418
38positive regulation of fatty acid beta-oxidation (GO:0032000)3.29422590
39growth hormone receptor signaling pathway (GO:0060396)3.28434773
40fatty acid beta-oxidation (GO:0006635)3.26615511
41positive regulation of fatty acid oxidation (GO:0046321)3.24560533
42striated muscle hypertrophy (GO:0014897)3.22829701
43NADH metabolic process (GO:0006734)3.22452431
44cytoskeletal anchoring at plasma membrane (GO:0007016)3.21722488
45lysine metabolic process (GO:0006553)3.20049850
46lysine catabolic process (GO:0006554)3.20049850
47regulation of cardioblast differentiation (GO:0051890)3.19874893
48cardiac muscle tissue morphogenesis (GO:0055008)3.18811270
49ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.18169359
50atrioventricular valve morphogenesis (GO:0003181)3.15872556
51regulation of the force of heart contraction (GO:0002026)3.15170919
52actin-mediated cell contraction (GO:0070252)3.14934612
53insulin-like growth factor receptor signaling pathway (GO:0048009)3.10439726
54valine metabolic process (GO:0006573)3.09657158
55regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.09198949
56epithelial cell-cell adhesion (GO:0090136)3.08536087
57regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.03869371
58negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.02447216
59regulation of skeletal muscle contraction (GO:0014819)3.02234230
60basement membrane organization (GO:0071711)3.01092935
61regulation of fatty acid beta-oxidation (GO:0031998)2.98221178
62positive regulation of glycogen biosynthetic process (GO:0045725)2.97094658
63regulation of p38MAPK cascade (GO:1900744)2.96487203
64adherens junction assembly (GO:0034333)2.96063816
65semaphorin-plexin signaling pathway (GO:0071526)2.95882022
66relaxation of cardiac muscle (GO:0055119)2.92231005
67oxaloacetate metabolic process (GO:0006107)2.91136106
68endothelial cell chemotaxis (GO:0035767)2.91030038
69muscle tissue morphogenesis (GO:0060415)2.90532777
70vascular endothelial growth factor signaling pathway (GO:0038084)2.90430395
71striated muscle contraction (GO:0006941)2.90296813
72endocardial cushion development (GO:0003197)2.87940275
73cell migration involved in heart development (GO:0060973)2.85922409
74regulation of relaxation of muscle (GO:1901077)2.85321960
75regulation of striated muscle contraction (GO:0006942)2.84199993
76regulation of sarcomere organization (GO:0060297)2.84143156
77membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.83162996
78cell-substrate adherens junction assembly (GO:0007045)2.82105410
79focal adhesion assembly (GO:0048041)2.82105410
80COPI coating of Golgi vesicle (GO:0048205)2.81729844
81Golgi transport vesicle coating (GO:0048200)2.81729844
82cellular response to growth hormone stimulus (GO:0071378)2.80749116
83renal filtration (GO:0097205)2.78374992
84muscle hypertrophy (GO:0014896)2.77461957
85actin filament-based movement (GO:0030048)2.76848102
86cardiac muscle hypertrophy in response to stress (GO:0014898)2.76525617
87muscle hypertrophy in response to stress (GO:0003299)2.76525617
88cardiac muscle adaptation (GO:0014887)2.76525617
89cell-substrate junction assembly (GO:0007044)2.75989037
90fatty acid oxidation (GO:0019395)2.75755928
91regulation of cardiac muscle cell contraction (GO:0086004)2.75064895
92creatine metabolic process (GO:0006600)2.75032926
93regulation of acyl-CoA biosynthetic process (GO:0050812)2.72253981
94regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.70177707
95fatty acid catabolic process (GO:0009062)2.69718689
96regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.69475233
97desmosome organization (GO:0002934)2.69373430
98negative regulation of cell size (GO:0045792)2.69369825
99negative regulation of fatty acid transport (GO:2000192)2.68822129
100lipid oxidation (GO:0034440)2.68292241
101protein heterotrimerization (GO:0070208)2.67670549
102glomerular filtration (GO:0003094)2.66990056
103regulation of membrane repolarization (GO:0060306)2.66672632
104quaternary ammonium group transport (GO:0015697)2.64338876
105cardiac muscle cell action potential involved in contraction (GO:0086002)2.63952930
106coronary vasculature morphogenesis (GO:0060977)2.61628382
107cardiac muscle cell action potential (GO:0086001)2.61520733
108intracellular lipid transport (GO:0032365)2.60611342
109gap junction assembly (GO:0016264)2.60384575
110positive regulation of glycogen metabolic process (GO:0070875)2.59315945
111retina vasculature morphogenesis in camera-type eye (GO:0061299)2.59150289
112membrane repolarization during action potential (GO:0086011)2.58776613
113actin filament depolymerization (GO:0030042)2.58546934
114biotin metabolic process (GO:0006768)2.58468873
115negative regulation of catenin import into nucleus (GO:0035414)2.58320578
116cardiac conduction (GO:0061337)2.58192455
117cardiac muscle cell proliferation (GO:0060038)2.57835905
118outflow tract septum morphogenesis (GO:0003148)2.56723445
119succinate metabolic process (GO:0006105)2.55400899
120regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.55221111
121negative regulation of striated muscle cell apoptotic process (GO:0010664)2.54925929
122low-density lipoprotein particle clearance (GO:0034383)2.54788918
123regulation of heart rate by cardiac conduction (GO:0086091)2.54131150
124protein retention in ER lumen (GO:0006621)2.53932895
125cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.53302898
126hemidesmosome assembly (GO:0031581)2.48101161
127axon extension involved in axon guidance (GO:0048846)2.45099303
128neuron projection extension involved in neuron projection guidance (GO:1902284)2.45099303
129cell-cell junction maintenance (GO:0045217)2.42411944
130Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.41786897
131cell junction maintenance (GO:0034331)2.41704849
132maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.39145093
133atrial septum morphogenesis (GO:0060413)2.35159716
134retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.33657978
135endothelial cell morphogenesis (GO:0001886)2.33326954
136cGMP-mediated signaling (GO:0019934)2.33279430
137regulation of axon extension involved in axon guidance (GO:0048841)2.31722966
138regulation of glucose import in response to insulin stimulus (GO:2001273)2.30445976
139glomerular basement membrane development (GO:0032836)2.29105849
140sequestering of extracellular ligand from receptor (GO:0035581)2.28604319
141negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.28572376
142collagen fibril organization (GO:0030199)2.28445180
143branching involved in salivary gland morphogenesis (GO:0060445)2.28065973
144regulation of establishment of planar polarity (GO:0090175)2.27461010
145camera-type eye morphogenesis (GO:0048593)2.25625221
146bone trabecula formation (GO:0060346)2.24800483
147endodermal cell differentiation (GO:0035987)2.24669861
148paraxial mesoderm development (GO:0048339)2.23887507
149negative regulation of chondrocyte differentiation (GO:0032331)2.22422137
150heart valve morphogenesis (GO:0003179)2.21194642
151peripheral nervous system axon ensheathment (GO:0032292)2.20464341
152myelination in peripheral nervous system (GO:0022011)2.20464341
153barbed-end actin filament capping (GO:0051016)2.19103302
154dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.18292728
155non-canonical Wnt signaling pathway (GO:0035567)2.16523042
156negative regulation of protein localization to cell surface (GO:2000009)2.14233675
157vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.12429443
158sodium ion export (GO:0071436)2.10851079
159neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.09407745
160trabecula formation (GO:0060343)2.09402197

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.13866962
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.29699255
3CLOCK_20551151_ChIP-Seq_293T_Human2.77849770
4EP300_21415370_ChIP-Seq_HL-1_Mouse2.74649304
5* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.61466000
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.59828148
7ZNF263_19887448_ChIP-Seq_K562_Human2.52453207
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.51396290
9* TBX20_22328084_ChIP-Seq_HEART_Mouse2.36710290
10* TBX20_22080862_ChIP-Seq_HEART_Mouse2.36710290
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.29509352
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.20140790
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.05611629
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.03726872
15ESR2_21235772_ChIP-Seq_MCF-7_Human1.97295830
16STAT6_21828071_ChIP-Seq_BEAS2B_Human1.95718038
17RXR_22158963_ChIP-Seq_LIVER_Mouse1.93726541
18PPARA_22158963_ChIP-Seq_LIVER_Mouse1.93419542
19ESR1_20079471_ChIP-ChIP_T-47D_Human1.90508349
20* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.86865682
21ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.85672220
22ERG_21242973_ChIP-ChIP_JURKAT_Human1.80600636
23TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.79781239
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.75343509
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.74747803
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73384736
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.66407821
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.66385522
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60241048
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.55547502
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53310364
32KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52737889
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47518819
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.47429645
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.46148152
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.45870872
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.45558729
38SOX2_27498859_Chip-Seq_STOMACH_Mouse1.42861066
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.41501112
40KDM2B_26808549_Chip-Seq_K562_Human1.41285142
41CTCF_27219007_Chip-Seq_Bcells_Human1.40301876
42RACK7_27058665_Chip-Seq_MCF-7_Human1.40296319
43KDM2B_26808549_Chip-Seq_DND41_Human1.38080032
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37396427
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.36118962
46FOXA2_19822575_ChIP-Seq_HepG2_Human1.34804892
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.34420435
48* EZH2_27294783_Chip-Seq_ESCs_Mouse1.34181028
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.32058091
50ISL1_27105846_Chip-Seq_CPCs_Mouse1.31606162
51DROSHA_22980978_ChIP-Seq_HELA_Human1.31218566
52* RNF2_27304074_Chip-Seq_ESCs_Mouse1.30759412
53RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29131693
54* RUNX1_27514584_Chip-Seq_MCF-7_Human1.28303287
55BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.27646161
56P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26715138
57FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.26614712
58GATA1_22025678_ChIP-Seq_K562_Human1.25852817
59CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.25356837
60SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24599702
61SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24233996
62SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24131812
63TP53_20018659_ChIP-ChIP_R1E_Mouse1.23554843
64MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.23302682
65GATA1_19941826_ChIP-Seq_K562_Human1.22497928
66ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22415223
67ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21276375
68* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21085613
69* EZH2_27304074_Chip-Seq_ESCs_Mouse1.21002443
70* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20691504
71LXR_22292898_ChIP-Seq_THP-1_Human1.20326781
72SMC4_20622854_ChIP-Seq_HELA_Human1.19342412
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.19095111
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18718052
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18192762
76* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.18075979
77DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16982706
78* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16566567
79SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16479776
80ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13568041
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12893410
82TET1_21490601_ChIP-Seq_MESCs_Mouse1.12795755
83TP53_22127205_ChIP-Seq_IMR90_Human1.12745176
84AHR_22903824_ChIP-Seq_MCF-7_Human1.11558851
85TET1_21451524_ChIP-Seq_MESCs_Mouse1.11438853
86CDX2_20551321_ChIP-Seq_CACO-2_Human1.10991881
87CREB1_26743006_Chip-Seq_LNCaP_Human1.09464203
88CJUN_26792858_Chip-Seq_BT549_Human1.08991090
89* ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08629131
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07975243
91ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07005234
92RING1B_27294783_Chip-Seq_NPCs_Mouse1.06301208
93* TP53_23651856_ChIP-Seq_MEFs_Mouse1.06170329
94HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05714606
95NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05540912
96ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04835676
97PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03628613
98OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.03492498
99KDM2B_26808549_Chip-Seq_JURKAT_Human1.03224232
100GATA6_25053715_ChIP-Seq_YYC3_Human1.01836624
101RNF2_18974828_ChIP-Seq_MESCs_Mouse1.01516474
102EZH2_18974828_ChIP-Seq_MESCs_Mouse1.01516474
103ATF3_27146783_Chip-Seq_COLON_Human1.01457846
104SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01433156
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01406767
106CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00873522
107SMC3_22415368_ChIP-Seq_MEFs_Mouse1.00641910
108* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00339324
109TCF7_22412390_ChIP-Seq_EML_Mouse0.99231402
110* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98735127
111* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98314259
112PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96557668
113GATA4_25053715_ChIP-Seq_YYC3_Human0.96454190
114ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95952174
115GATA2_19941826_ChIP-Seq_K562_Human0.94965054
116CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94915266
117SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94539091
118SOX2_20726797_ChIP-Seq_SW620_Human0.94442698
119* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.93659755
120SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.93191997
121NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92956556
122TP63_22573176_ChIP-Seq_HFKS_Human0.92742349
123NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91134399
124SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90080122
125TCF4_18268006_ChIP-ChIP_LS174T_Human0.88621712
126SMAD3_21741376_ChIP-Seq_HESCs_Human0.87680915
127STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.87417668
128KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.87288364
129TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86617198
130SMAD4_21741376_ChIP-Seq_HESCs_Human0.85989235
131UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85734297
132TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85526275
133SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85103922

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.24351646
2MP0004084_abnormal_cardiac_muscle4.38106234
3MP0000751_myopathy3.63222181
4MP0004215_abnormal_myocardial_fiber3.22253010
5MP0004036_abnormal_muscle_relaxation3.00656742
6MP0003646_muscle_fatigue2.85816296
7MP0004130_abnormal_muscle_cell2.85541060
8MP0003705_abnormal_hypodermis_morpholog2.84010757
9MP0005330_cardiomyopathy2.79048983
10MP0008438_abnormal_cutaneous_collagen2.59665495
11MP0004087_abnormal_muscle_fiber2.37791879
12MP0005666_abnormal_adipose_tissue2.35968099
13MP0005670_abnormal_white_adipose2.35889700
14MP0006138_congestive_heart_failure2.30892972
15* MP0002972_abnormal_cardiac_muscle2.29290698
16MP0010630_abnormal_cardiac_muscle2.19095742
17MP0000749_muscle_degeneration2.16415636
18MP0005409_darkened_coat_color2.14215695
19MP0010030_abnormal_orbit_morphology2.06716349
20MP0005385_cardiovascular_system_phenoty2.05473137
21MP0001544_abnormal_cardiovascular_syste2.05473137
22* MP0008775_abnormal_heart_ventricle1.99559206
23MP0004858_abnormal_nervous_system1.97566877
24MP0004185_abnormal_adipocyte_glucose1.96015764
25* MP0005620_abnormal_muscle_contractility1.94610847
26MP0004272_abnormal_basement_membrane1.93613752
27MP0000750_abnormal_muscle_regeneration1.89614028
28MP0005275_abnormal_skin_tensile1.84355312
29MP0003137_abnormal_impulse_conducting1.84232321
30MP0005375_adipose_tissue_phenotype1.79801372
31MP0005257_abnormal_intraocular_pressure1.78065925
32MP0000566_synostosis1.76649930
33MP0002138_abnormal_hepatobiliary_system1.71298701
34MP0004510_myositis1.70643781
35MP0005623_abnormal_meninges_morphology1.61831344
36MP0004484_altered_response_of1.61659542
37MP0003828_pulmonary_edema1.59889712
38MP0002106_abnormal_muscle_physiology1.54547395
39MP0000013_abnormal_adipose_tissue1.53749718
40MP0002249_abnormal_larynx_morphology1.52775043
41MP0000534_abnormal_ureter_morphology1.52217152
42MP0002269_muscular_atrophy1.51856605
43MP0003566_abnormal_cell_adhesion1.49535367
44MP0010368_abnormal_lymphatic_system1.48057118
45MP0004085_abnormal_heartbeat1.47824201
46MP0001849_ear_inflammation1.45162232
47MP0004233_abnormal_muscle_weight1.42776892
48MP0000003_abnormal_adipose_tissue1.41580015
49MP0003252_abnormal_bile_duct1.40817476
50MP0003283_abnormal_digestive_organ1.40160514
51MP0009780_abnormal_chondrocyte_physiolo1.39661485
52MP0010234_abnormal_vibrissa_follicle1.37229241
53MP0003279_aneurysm1.35178204
54MP0004264_abnormal_extraembryonic_tissu1.35146603
55MP0000759_abnormal_skeletal_muscle1.34703911
56MP0001879_abnormal_lymphatic_vessel1.32429339
57MP0008961_abnormal_basal_metabolism1.31116149
58MP0000462_abnormal_digestive_system1.30849929
59MP0003045_fibrosis1.30350753
60MP0005369_muscle_phenotype1.28410079
61MP0002877_abnormal_melanocyte_morpholog1.27617622
62MP0000747_muscle_weakness1.26448725
63MP0000762_abnormal_tongue_morphology1.24540683
64MP0002234_abnormal_pharynx_morphology1.23993911
65MP0003942_abnormal_urinary_system1.19451245
66MP0004043_abnormal_pH_regulation1.12459001
67MP0002971_abnormal_brown_adipose1.11141117
68MP0001299_abnormal_eye_distance/1.10095446
69MP0002254_reproductive_system_inflammat1.09831604
70MP0000579_abnormal_nail_morphology1.09424663
71MP0005365_abnormal_bile_salt1.08675662
72MP0005360_urolithiasis1.07550448
73MP0005508_abnormal_skeleton_morphology1.07425190
74MP0002127_abnormal_cardiovascular_syste1.05852551
75MP0003221_abnormal_cardiomyocyte_apopto1.04369406
76MP0001666_abnormal_nutrient_absorption1.02839268
77MP0000467_abnormal_esophagus_morphology1.02684724
78MP0009384_cardiac_valve_regurgitation1.01193990
79MP0000266_abnormal_heart_morphology1.00165614
80MP0002166_altered_tumor_susceptibility0.99981523
81MP0001958_emphysema0.99417639
82MP0002089_abnormal_postnatal_growth/wei0.98137010
83MP0003300_gastrointestinal_ulcer0.98092590
84MP0003950_abnormal_plasma_membrane0.97977723
85MP0005187_abnormal_penis_morphology0.96345774
86MP0000767_abnormal_smooth_muscle0.95609908
87MP0000733_abnormal_muscle_development0.95319684
88MP0005248_abnormal_Harderian_gland0.93617222
89MP0004145_abnormal_muscle_electrophysio0.93441218
90MP0001664_abnormal_digestion0.92246761
91MP0003941_abnormal_skin_development0.91921231
92MP0000230_abnormal_systemic_arterial0.90402522
93MP0003567_abnormal_fetal_cardiomyocyte0.89741025
94MP0000537_abnormal_urethra_morphology0.89292291
95MP0003385_abnormal_body_wall0.88193225
96MP0002909_abnormal_adrenal_gland0.87418617
97MP0002796_impaired_skin_barrier0.87103842
98MP0004782_abnormal_surfactant_physiolog0.87046558
99MP0010352_gastrointestinal_tract_polyps0.86135445
100MP0002108_abnormal_muscle_morphology0.85803367
101MP0005085_abnormal_gallbladder_physiolo0.84484723
102MP0002128_abnormal_blood_circulation0.84396117
103MP0002896_abnormal_bone_mineralization0.84123210
104MP0010329_abnormal_lipoprotein_level0.83448661
105MP0002098_abnormal_vibrissa_morphology0.83110123
106MP0002118_abnormal_lipid_homeostasis0.81294690
107MP0000538_abnormal_urinary_bladder0.79819803
108MP0005334_abnormal_fat_pad0.79230672
109MP0009115_abnormal_fat_cell0.78902498
110MP0001348_abnormal_lacrimal_gland0.78616691
111MP0009053_abnormal_anal_canal0.78560818
112MP0005503_abnormal_tendon_morphology0.77230325
113MP0005023_abnormal_wound_healing0.76771154
114MP0005165_increased_susceptibility_to0.76416198
115MP0003959_abnormal_lean_body0.75390046
116MP0003091_abnormal_cell_migration0.75312886
117MP0002139_abnormal_hepatobiliary_system0.75257118
118MP0005595_abnormal_vascular_smooth0.74855967
119MP0002078_abnormal_glucose_homeostasis0.74789032
120MP0002116_abnormal_craniofacial_bone0.74755809
121MP0002295_abnormal_pulmonary_circulatio0.74230891
122MP0000678_abnormal_parathyroid_gland0.73898950
123MP0005167_abnormal_blood-brain_barrier0.73811795
124* MP0009643_abnormal_urine_homeostasis0.73520930
125MP0003329_amyloid_beta_deposits0.72613809
126MP0000163_abnormal_cartilage_morphology0.71552817
127* MP0001765_abnormal_ion_homeostasis0.71284215
128MP0009250_abnormal_appendicular_skeleto0.69264323
129MP0005076_abnormal_cell_differentiation0.68306587
130MP0002932_abnormal_joint_morphology0.68059306
131MP0001614_abnormal_blood_vessel0.67956869
132MP0009840_abnormal_foam_cell0.67342704
133MP0003115_abnormal_respiratory_system0.67187758
134MP0005083_abnormal_biliary_tract0.66507001
135MP0002925_abnormal_cardiovascular_devel0.64836094
136MP0002060_abnormal_skin_morphology0.64342508
137MP0006054_spinal_hemorrhage0.64250881
138MP0005332_abnormal_amino_acid0.62203680

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.97397625
2Right ventricular cardiomyopathy (HP:0011663)5.20506490
3Ventricular tachycardia (HP:0004756)4.99823901
4Atrial fibrillation (HP:0005110)4.20187984
5Muscle fiber splitting (HP:0003555)4.18976664
6Lipoatrophy (HP:0100578)4.06614415
7Hyporeflexia of lower limbs (HP:0002600)4.02066087
8Primary atrial arrhythmia (HP:0001692)3.91118196
9Syncope (HP:0001279)3.89317434
10Increased connective tissue (HP:0009025)3.79279539
11Myoglobinuria (HP:0002913)3.72259752
12Supraventricular arrhythmia (HP:0005115)3.70915049
13Supraventricular tachycardia (HP:0004755)3.69753246
14Calf muscle hypertrophy (HP:0008981)3.66488695
15Subaortic stenosis (HP:0001682)3.66010054
16Abnormality of the left ventricular outflow tract (HP:0011103)3.66010054
17Prolonged QT interval (HP:0001657)3.60769798
18Exercise-induced myalgia (HP:0003738)3.56547248
19Bundle branch block (HP:0011710)3.56502921
20Abnormality of the calf musculature (HP:0001430)3.55942464
21Exercise-induced muscle cramps (HP:0003710)3.33234739
22Ventricular arrhythmia (HP:0004308)3.26969288
23Palpitations (HP:0001962)3.25391745
24Ventricular fibrillation (HP:0001663)3.22858030
25Broad metatarsal (HP:0001783)3.22284209
26Dilated cardiomyopathy (HP:0001644)3.22208820
27Muscle hypertrophy of the lower extremities (HP:0008968)3.17613848
28Difficulty running (HP:0009046)3.14155955
29Ketoacidosis (HP:0001993)3.14007071
30Hypoglycemic coma (HP:0001325)3.13350262
31Cervical subluxation (HP:0003308)3.07359819
32Mildly elevated creatine phosphokinase (HP:0008180)2.87743971
33Atrioventricular block (HP:0001678)2.87472327
34Asymmetric septal hypertrophy (HP:0001670)2.86510359
35Lymphangioma (HP:0100764)2.85073101
36Vascular tortuosity (HP:0004948)2.82491087
37Heart block (HP:0012722)2.79737022
38Arterial tortuosity (HP:0005116)2.77201049
39Type 1 muscle fiber predominance (HP:0003803)2.74819157
40Cerebral aneurysm (HP:0004944)2.70182504
41Abnormal atrioventricular conduction (HP:0005150)2.70013560
42Neonatal short-limb short stature (HP:0008921)2.63433682
43Distal lower limb muscle weakness (HP:0009053)2.58268223
44EMG: myopathic abnormalities (HP:0003458)2.57427995
45Increased variability in muscle fiber diameter (HP:0003557)2.57122504
46Rhabdomyolysis (HP:0003201)2.55818362
47Protrusio acetabuli (HP:0003179)2.52601662
48Aneurysm (HP:0002617)2.47917266
49Difficulty climbing stairs (HP:0003551)2.46134719
50Abnormality of fatty-acid metabolism (HP:0004359)2.38236274
51Ankle contracture (HP:0006466)2.37607031
52Abnormal EKG (HP:0003115)2.36213885
53Ketosis (HP:0001946)2.35110958
54Hyperacusis (HP:0010780)2.33970476
55Premature rupture of membranes (HP:0001788)2.32820146
56Wormian bones (HP:0002645)2.31521754
57Myotonia (HP:0002486)2.22274690
58Hamartoma of the eye (HP:0010568)2.19306232
59Blue sclerae (HP:0000592)2.17691210
60Conjunctival hamartoma (HP:0100780)2.17131128
61Vertebral compression fractures (HP:0002953)2.16165547
62Abnormality of dentin (HP:0010299)2.14489347
63Ulnar bowing (HP:0003031)2.14087690
64Scapular winging (HP:0003691)2.13868246
65Rectal prolapse (HP:0002035)2.13464267
66Broad face (HP:0000283)2.13072991
67Soft skin (HP:0000977)2.12496091
68Abnormality of skeletal muscle fiber size (HP:0012084)2.12347443
69Polycythemia (HP:0001901)2.12206244
70Aortic aneurysm (HP:0004942)2.11428312
71Visceral angiomatosis (HP:0100761)2.11333956
72Hyperglycemia (HP:0003074)2.07266610
73Bronchomalacia (HP:0002780)2.06221592
74Atrophic scars (HP:0001075)2.05065656
75Hyperglycinuria (HP:0003108)2.04991230
76Mitral regurgitation (HP:0001653)2.04679432
77Distal upper limb amyotrophy (HP:0007149)2.03543778
78Upper limb amyotrophy (HP:0009129)2.03543778
79Short nail (HP:0001799)2.02216207
80Hyperinsulinemic hypoglycemia (HP:0000825)1.99154516
81Aortic dissection (HP:0002647)1.96464569
82Obstructive sleep apnea (HP:0002870)1.96445481
83Shallow orbits (HP:0000586)1.96347870
84Abnormality of the distal phalanx of the thumb (HP:0009617)1.96240366
85Hemangiomatosis (HP:0007461)1.96212103
86Sudden cardiac death (HP:0001645)1.95856325
87Partial duplication of thumb phalanx (HP:0009944)1.95854197
88Fragile skin (HP:0001030)1.94893409
89Abnormality of carpal bone ossification (HP:0006257)1.93152285
90Skin nodule (HP:0200036)1.93058339
91Turricephaly (HP:0000262)1.91294570
92Hypoplastic ischia (HP:0003175)1.90662350
93Insulin-resistant diabetes mellitus (HP:0000831)1.90551036
94Pigmentary retinal degeneration (HP:0001146)1.89523984
95Central scotoma (HP:0000603)1.87224204
96Dysmetric saccades (HP:0000641)1.86311718
97Spinal rigidity (HP:0003306)1.86104659
98Partial duplication of the phalanx of hand (HP:0009999)1.86021250
99Enlarged penis (HP:0000040)1.85149646
100Biconcave vertebral bodies (HP:0004586)1.84676746
101Infantile muscular hypotonia (HP:0008947)1.84609554
102Long toe (HP:0010511)1.83969870
103Abnormality of the acetabulum (HP:0003170)1.83649380
104Hemorrhage of the eye (HP:0011885)1.82635232
105Osteoarthritis (HP:0002758)1.82534696
106Dicarboxylic aciduria (HP:0003215)1.82266825
107Abnormality of dicarboxylic acid metabolism (HP:0010995)1.82266825
108Wide anterior fontanel (HP:0000260)1.81930427
109Joint laxity (HP:0001388)1.79259454
110Abnormal ossification of hand bones (HP:0005921)1.78106125
111Hydroxyprolinuria (HP:0003080)1.77790499
112Abnormality of proline metabolism (HP:0010907)1.77790499
113Hyperextensible skin (HP:0000974)1.77139817
114Mitral stenosis (HP:0001718)1.76928790
115Thin bony cortex (HP:0002753)1.76678675
116Limb-girdle muscle atrophy (HP:0003797)1.76451696
117Coxa vara (HP:0002812)1.75988025
118Hypoplasia of the iris (HP:0007676)1.75472846
119Genu recurvatum (HP:0002816)1.75314459
120Bradycardia (HP:0001662)1.75231698
121Hypoventilation (HP:0002791)1.74983058
122Bowel diverticulosis (HP:0005222)1.74663716
123Cupped ribs (HP:0000887)1.74433053
124Lower limb amyotrophy (HP:0007210)1.73468278
125Centrally nucleated skeletal muscle fibers (HP:0003687)1.72605921
126Pheochromocytoma (HP:0002666)1.72486054
127Congenital glaucoma (HP:0001087)1.71726240
128Bladder diverticulum (HP:0000015)1.70691870
129Advanced eruption of teeth (HP:0006288)1.70615700
130Thin ribs (HP:0000883)1.70537642
131Neonatal death (HP:0003811)1.70449503
132Acanthosis nigricans (HP:0000956)1.68383874
133Overgrowth (HP:0001548)1.68093574
134Pulmonary artery stenosis (HP:0004415)1.67560498
135Aortic regurgitation (HP:0001659)1.67006621
136Mitral valve prolapse (HP:0001634)1.66895431
137Abnormality of the ischium (HP:0003174)1.66794816
138Hyperammonemia (HP:0001987)1.65664008
139Dilatation of the ascending aorta (HP:0005111)1.64687117
140Generalized muscle weakness (HP:0003324)1.63881182
141Asymmetry of the thorax (HP:0001555)1.63726706
142Palmoplantar keratoderma (HP:0000982)1.63687288
143Congestive heart failure (HP:0001635)1.63313211
144Ileus (HP:0002595)1.63291559
145Ectopia lentis (HP:0001083)1.62859392
146Flattened epiphyses (HP:0003071)1.62816692
147Cavernous hemangioma (HP:0001048)1.61585117
148Esophageal varix (HP:0002040)1.60251628
149Abnormality of serine family amino acid metabolism (HP:0010894)1.59821812
150Abnormality of glycine metabolism (HP:0010895)1.59821812
151Distal lower limb amyotrophy (HP:0008944)1.59720297
152Pancreatic islet-cell hyperplasia (HP:0004510)1.58892184
153Flat acetabular roof (HP:0003180)1.58267711
154Proximal amyotrophy (HP:0007126)1.58046377

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.21257566
2TTN4.05357414
3PKN23.61884079
4LMTK23.33308021
5EPHA23.23514896
6MYLK2.61414526
7RIPK12.42715366
8DMPK2.23781271
9SIK12.21522401
10LATS12.09781593
11PDGFRA2.09301787
12WNK42.00117018
13NTRK11.88012564
14PIK3CA1.85856154
15PDK31.85264202
16PDK41.85264202
17PTK61.81448962
18PHKG11.76932043
19PHKG21.76932043
20TESK11.72584377
21INSRR1.72170548
22BCKDK1.71999259
23TIE11.71440021
24OBSCN1.61728696
25PAK31.48676119
26EPHB21.46328631
27FLT31.45638671
28CAMK1D1.44554959
29PRKAA21.38778881
30MAP3K101.35932792
31FRK1.35698916
32CDK121.30881928
33SMG11.25586954
34MAP3K71.25423700
35FGFR41.23321804
36CAMK1G1.23108796
37ERN11.23001151
38ICK1.17257027
39EPHB11.16830317
40EEF2K1.13600004
41DDR21.12982903
42RET1.10229789
43MAPK151.07587706
44PRKD11.04617895
45PDK21.04372871
46FER1.03827770
47MARK11.03641340
48CDC42BPA1.01493148
49MST1R1.00507393
50ILK0.97108597
51PDGFRB0.96355814
52PRKAA10.95260989
53JAK10.94361203
54PTK20.93274113
55ROCK10.93065242
56MAP3K60.91529893
57STK240.90812631
58LIMK10.90182405
59NEK10.87847298
60WNK10.86733419
61MARK20.86194026
62PRKD30.83628431
63TYRO30.82250298
64MTOR0.81881600
65FGFR30.80411701
66STK390.78865152
67AKT30.76724079
68TAOK30.75080157
69LRRK20.74675094
70TRPM70.72444856
71PAK20.72072335
72MUSK0.70191239
73TGFBR20.69418695
74PTK2B0.68536537
75MET0.68387845
76FGFR20.67114443
77CAMK10.65236286
78STK38L0.64070634
79RPS6KC10.63495555
80RPS6KL10.63495555
81PRKCH0.62440897
82EPHA30.58898978
83STK380.58460063
84BMX0.58451560
85CAMK2D0.54973286
86STK30.54137092
87RPS6KB20.54077642
88TYK20.53841539
89MAP3K20.52868290
90NEK90.52030411
91CAMK2G0.51428735
92PKN10.50649727
93JAK20.49892457
94MAP2K10.49316650
95SGK30.48390691
96KSR20.48347209
97CAMK40.48029975
98MAPK120.47838582
99MAPKAPK30.47807387
100EPHA40.47512795
101RPS6KA60.47426679
102FGFR10.46723477
103AKT20.45441014
104MAP2K20.45138184
105CHUK0.45005384
106CAMK2B0.43602473
107KDR0.43564243
108DAPK30.43509220
109PDPK10.43151780
110PRKG20.42507409
111LATS20.41470743
112DYRK1B0.40354630
113MAP3K10.40054874
114ARAF0.39693231
115MAP3K30.39031057
116PRKD20.38198647
117PRKACG0.37650100
118ROCK20.37520568
119WNK30.35320556
120RPS6KA20.35222261
121TAOK10.35043216
122ERBB20.34802104
123PAK40.34164309
124MAPK70.33675850
125GSK3A0.33554009
126JAK30.33196004
127SRC0.33115788
128PRPF4B0.32331409

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.11151156
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.14912642
3Fatty acid degradation_Homo sapiens_hsa000712.77797347
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.73557364
5Propanoate metabolism_Homo sapiens_hsa006402.71116251
6* Dilated cardiomyopathy_Homo sapiens_hsa054142.48116437
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.44772097
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.41402018
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.30356371
10Fatty acid metabolism_Homo sapiens_hsa012122.17680690
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.07331453
12Cardiac muscle contraction_Homo sapiens_hsa042601.95385317
13PPAR signaling pathway_Homo sapiens_hsa033201.89870312
14Carbon metabolism_Homo sapiens_hsa012001.63933604
15Insulin resistance_Homo sapiens_hsa049311.55395140
16Butanoate metabolism_Homo sapiens_hsa006501.45561332
17Pyruvate metabolism_Homo sapiens_hsa006201.44130572
18Adipocytokine signaling pathway_Homo sapiens_hsa049201.43350097
19ECM-receptor interaction_Homo sapiens_hsa045121.39536726
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36325345
21Lysine degradation_Homo sapiens_hsa003101.36250714
22Protein digestion and absorption_Homo sapiens_hsa049741.33428247
23Fat digestion and absorption_Homo sapiens_hsa049751.33261471
24Tryptophan metabolism_Homo sapiens_hsa003801.33082951
25Focal adhesion_Homo sapiens_hsa045101.32791349
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.32445681
27Histidine metabolism_Homo sapiens_hsa003401.30110544
28Viral myocarditis_Homo sapiens_hsa054161.28775198
29* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.24928957
30Type II diabetes mellitus_Homo sapiens_hsa049301.20391280
31AMPK signaling pathway_Homo sapiens_hsa041521.18765013
32* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18211822
33Nitrogen metabolism_Homo sapiens_hsa009101.14269622
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.13553422
35Axon guidance_Homo sapiens_hsa043601.11471287
36Sulfur metabolism_Homo sapiens_hsa009201.10910975
37Arginine biosynthesis_Homo sapiens_hsa002201.08148617
38Fatty acid biosynthesis_Homo sapiens_hsa000611.06240423
39Other glycan degradation_Homo sapiens_hsa005111.05347172
40* Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04467367
41Insulin signaling pathway_Homo sapiens_hsa049101.04300485
42Renin-angiotensin system_Homo sapiens_hsa046141.03905688
43Starch and sucrose metabolism_Homo sapiens_hsa005000.99328844
44Basal cell carcinoma_Homo sapiens_hsa052170.99045491
45Arginine and proline metabolism_Homo sapiens_hsa003300.98715677
46Glucagon signaling pathway_Homo sapiens_hsa049220.96267300
47Tyrosine metabolism_Homo sapiens_hsa003500.93206117
48Adherens junction_Homo sapiens_hsa045200.92928462
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91597510
50Small cell lung cancer_Homo sapiens_hsa052220.90811784
51* Melanogenesis_Homo sapiens_hsa049160.89944365
52Glycerolipid metabolism_Homo sapiens_hsa005610.88524203
53Prion diseases_Homo sapiens_hsa050200.88507189
54* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87933622
55* Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85599117
56Amoebiasis_Homo sapiens_hsa051460.84239589
57Vitamin digestion and absorption_Homo sapiens_hsa049770.83049426
58* Bile secretion_Homo sapiens_hsa049760.82535998
59Tight junction_Homo sapiens_hsa045300.82463705
60beta-Alanine metabolism_Homo sapiens_hsa004100.82439534
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81377679
62Proteoglycans in cancer_Homo sapiens_hsa052050.79961385
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78373334
64Hedgehog signaling pathway_Homo sapiens_hsa043400.77555977
65Cocaine addiction_Homo sapiens_hsa050300.75713844
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.75311290
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74931716
68* Estrogen signaling pathway_Homo sapiens_hsa049150.73693411
69Sulfur relay system_Homo sapiens_hsa041220.72236922
70* Thyroid hormone synthesis_Homo sapiens_hsa049180.70928815
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67805472
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66301808
73* Pancreatic secretion_Homo sapiens_hsa049720.66048364
74mTOR signaling pathway_Homo sapiens_hsa041500.64934940
75Phenylalanine metabolism_Homo sapiens_hsa003600.64619842
76* Gap junction_Homo sapiens_hsa045400.64071636
77* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64004761
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63342674
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.63057141
80* Phospholipase D signaling pathway_Homo sapiens_hsa040720.62517626
81ErbB signaling pathway_Homo sapiens_hsa040120.62102932
82HIF-1 signaling pathway_Homo sapiens_hsa040660.60933345
83Biosynthesis of amino acids_Homo sapiens_hsa012300.60773744
84* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60742207
85* GnRH signaling pathway_Homo sapiens_hsa049120.60575800
86Choline metabolism in cancer_Homo sapiens_hsa052310.60521031
87Toxoplasmosis_Homo sapiens_hsa051450.60147755
88Dorso-ventral axis formation_Homo sapiens_hsa043200.59832036
89* Gastric acid secretion_Homo sapiens_hsa049710.59487385
90Thyroid cancer_Homo sapiens_hsa052160.59141692
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58891607
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58033069
93ABC transporters_Homo sapiens_hsa020100.57749766
94Chronic myeloid leukemia_Homo sapiens_hsa052200.56743372
95* Vascular smooth muscle contraction_Homo sapiens_hsa042700.55319606
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53136837
97Prostate cancer_Homo sapiens_hsa052150.52668449
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.51402730
99Endometrial cancer_Homo sapiens_hsa052130.50994080
100Fructose and mannose metabolism_Homo sapiens_hsa000510.50312792
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50285789
102Peroxisome_Homo sapiens_hsa041460.50017937
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49977226
104* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49941502
105Fatty acid elongation_Homo sapiens_hsa000620.49564727
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49327737
107* Renin secretion_Homo sapiens_hsa049240.45619675
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41087038
109* Insulin secretion_Homo sapiens_hsa049110.40458511
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40338828
111Bladder cancer_Homo sapiens_hsa052190.39804920
112* cAMP signaling pathway_Homo sapiens_hsa040240.37723997
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37701587
114* Oxytocin signaling pathway_Homo sapiens_hsa049210.37517900
115Mineral absorption_Homo sapiens_hsa049780.36935438
116Galactose metabolism_Homo sapiens_hsa000520.36300329
117Parkinsons disease_Homo sapiens_hsa050120.35806629
118Alzheimers disease_Homo sapiens_hsa050100.34729571
119Renal cell carcinoma_Homo sapiens_hsa052110.34661180
120VEGF signaling pathway_Homo sapiens_hsa043700.33602334
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32455951
122Prolactin signaling pathway_Homo sapiens_hsa049170.30888244
123Hippo signaling pathway_Homo sapiens_hsa043900.30745659
124Acute myeloid leukemia_Homo sapiens_hsa052210.30269010
125Notch signaling pathway_Homo sapiens_hsa043300.30204000
126Glioma_Homo sapiens_hsa052140.30149802
127Caffeine metabolism_Homo sapiens_hsa002320.29885780
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29541396
129FoxO signaling pathway_Homo sapiens_hsa040680.28288243

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