ADCY7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences. Several transcript variants have been observed for this gene, but the full-length natures of only two have been determined so far. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.52351750
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.57170603
3regulation of B cell receptor signaling pathway (GO:0050855)5.31952626
4negative regulation of cell killing (GO:0031342)5.29991772
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.29991772
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.15820509
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.15820509
8antigen processing and presentation of endogenous antigen (GO:0019883)4.89015053
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.83721744
10regulation of gamma-delta T cell differentiation (GO:0045586)4.68355280
11regulation of gamma-delta T cell activation (GO:0046643)4.57253231
12positive thymic T cell selection (GO:0045059)4.46872878
13detection of other organism (GO:0098543)4.35860493
14B cell receptor signaling pathway (GO:0050853)4.27880554
15positive regulation by symbiont of host defense response (GO:0052509)4.23531058
16modulation by symbiont of host defense response (GO:0052031)4.23531058
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.23531058
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.23531058
19positive regulation by organism of defense response of other organism involved in symbiotic interact4.23531058
20modulation by symbiont of host immune response (GO:0052553)4.23531058
21detection of bacterium (GO:0016045)4.16305192
22positive regulation of B cell differentiation (GO:0045579)4.15402091
23negative thymic T cell selection (GO:0045060)4.14037820
24negative T cell selection (GO:0043383)4.12520518
25T cell migration (GO:0072678)4.09991088
26negative regulation of T cell mediated immunity (GO:0002710)4.06037349
27regulation of interferon-beta biosynthetic process (GO:0045357)4.02601461
28regulation of B cell differentiation (GO:0045577)4.00076869
29negative regulation of erythrocyte differentiation (GO:0045647)3.96740181
30negative regulation of lymphocyte mediated immunity (GO:0002707)3.89102503
31leukocyte aggregation (GO:0070486)3.87325501
32activated T cell proliferation (GO:0050798)3.85115649
33response to interleukin-15 (GO:0070672)3.83454120
34interferon-gamma production (GO:0032609)3.71381965
35germinal center formation (GO:0002467)3.64615526
36detection of external biotic stimulus (GO:0098581)3.61831078
37thymic T cell selection (GO:0045061)3.60906240
38positive T cell selection (GO:0043368)3.57891932
39response to muramyl dipeptide (GO:0032495)3.53268498
40regulation of mast cell degranulation (GO:0043304)3.53191443
41neutrophil activation involved in immune response (GO:0002283)3.52666766
42cellular response to interleukin-15 (GO:0071350)3.50984742
43regulation of interleukin-12 biosynthetic process (GO:0045075)3.50148445
44positive regulation of interferon-alpha production (GO:0032727)3.50070705
45detection of molecule of bacterial origin (GO:0032490)3.43876242
46regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.41814967
47microglial cell activation (GO:0001774)3.38165461
48positive regulation of mast cell activation (GO:0033005)3.35948858
49immunoglobulin mediated immune response (GO:0016064)3.35493363
50T cell selection (GO:0045058)3.35134270
51response to type I interferon (GO:0034340)3.34616537
52regulation of myeloid leukocyte mediated immunity (GO:0002886)3.34499212
53regulation of interferon-alpha production (GO:0032647)3.34438537
54regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.31599285
55regulation of tolerance induction (GO:0002643)3.30531067
56cellular response to type I interferon (GO:0071357)3.26789342
57type I interferon signaling pathway (GO:0060337)3.26789342
58regulation of mast cell activation involved in immune response (GO:0033006)3.26480370
59macrophage activation involved in immune response (GO:0002281)3.25588463
60regulation of leukocyte degranulation (GO:0043300)3.23811259
61respiratory burst (GO:0045730)3.22310377
62regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.22193064
63tolerance induction (GO:0002507)3.21501814
64detection of biotic stimulus (GO:0009595)3.21326690
65antigen receptor-mediated signaling pathway (GO:0050851)3.21122506
66regulation of mast cell activation (GO:0033003)3.19296683
67regulation of alpha-beta T cell proliferation (GO:0046640)3.19246115
68response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.18463630
69response to host (GO:0075136)3.18463630
70response to host defenses (GO:0052200)3.18463630
71leukocyte cell-cell adhesion (GO:0007159)3.15654017
72NIK/NF-kappaB signaling (GO:0038061)3.14779981
73positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.14656031
74negative regulation of phagocytosis (GO:0050765)3.13593396
75macrophage activation (GO:0042116)3.12756792
76antigen processing and presentation via MHC class Ib (GO:0002475)3.12038926
77positive regulation of antigen processing and presentation (GO:0002579)3.10689078
78mast cell activation (GO:0045576)3.07553380
79positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.06861394
80myeloid cell activation involved in immune response (GO:0002275)3.06625402
81regulation of dendritic cell antigen processing and presentation (GO:0002604)3.05830965
82interferon-gamma-mediated signaling pathway (GO:0060333)3.05119239
83regulation of T cell tolerance induction (GO:0002664)3.04799573
84defense response to protozoan (GO:0042832)3.02522586
85pinocytosis (GO:0006907)3.01633720
86response to peptidoglycan (GO:0032494)3.01082566
87regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.00636530
88regulation of natural killer cell mediated immunity (GO:0002715)3.00636530
89cellular extravasation (GO:0045123)3.00387984
90regulation of type I interferon-mediated signaling pathway (GO:0060338)2.97604760
91leukocyte degranulation (GO:0043299)2.96751732
92neutrophil activation (GO:0042119)2.96688031
93B cell homeostasis (GO:0001782)2.95970050
94response to protozoan (GO:0001562)2.95937356
95negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.95000370
96positive regulation of granulocyte differentiation (GO:0030854)2.94350653
97positive regulation of isotype switching (GO:0045830)2.93577957
98positive regulation of mast cell activation involved in immune response (GO:0033008)2.92545637
99positive regulation of mast cell degranulation (GO:0043306)2.92545637
100regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.92027128
101regulation of antigen processing and presentation (GO:0002577)2.91288905
102Arp2/3 complex-mediated actin nucleation (GO:0034314)2.90640017
103negative regulation of innate immune response (GO:0045824)2.90600070
104T cell receptor signaling pathway (GO:0050852)2.89833320
105negative regulation of granulocyte differentiation (GO:0030853)2.84471345
106mannose metabolic process (GO:0006013)2.83535725
107positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.81406522
108lipopolysaccharide-mediated signaling pathway (GO:0031663)2.80497445
109production of molecular mediator involved in inflammatory response (GO:0002532)2.80025296
110negative regulation of interleukin-12 production (GO:0032695)2.79310979
111mature B cell differentiation (GO:0002335)2.78764219
112regulation of T cell receptor signaling pathway (GO:0050856)2.77954624
113lymphocyte homeostasis (GO:0002260)2.77406816
114T cell homeostasis (GO:0043029)2.76185731
115T cell costimulation (GO:0031295)2.75264967
116myeloid dendritic cell activation (GO:0001773)2.74837775
117granulocyte activation (GO:0036230)2.74649975
118negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.73359207
119positive regulation of alpha-beta T cell proliferation (GO:0046641)2.72400510
120lymphocyte costimulation (GO:0031294)2.70980929
121regulation of interleukin-2 biosynthetic process (GO:0045076)2.68758719
122regulation of response to interferon-gamma (GO:0060330)2.68303977
123negative regulation of leukocyte mediated immunity (GO:0002704)2.67736948
124cellular response to zinc ion (GO:0071294)2.67654867
125neutrophil mediated immunity (GO:0002446)2.67324768
126positive regulation of interleukin-2 production (GO:0032743)2.65957000
127positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.65640854
128heterotypic cell-cell adhesion (GO:0034113)2.65311125
129JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.64575472
130response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.63973560
131response to host immune response (GO:0052572)2.63973560
132regulation of isotype switching to IgG isotypes (GO:0048302)2.63659622
133B cell proliferation (GO:0042100)2.63549665
134regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.62888285
135B cell mediated immunity (GO:0019724)2.59265226
136immune response-activating cell surface receptor signaling pathway (GO:0002429)2.59041541

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human5.09455535
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.73402855
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.46658476
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.12526621
5* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.72479974
6E2F7_22180533_ChIP-Seq_HELA_Human3.54173167
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.49545426
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.29772073
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.24451011
10* SCL_19346495_ChIP-Seq_HPC-7_Human3.00455959
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.97355100
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.96713199
13VDR_21846776_ChIP-Seq_THP-1_Human2.92288080
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.89104236
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.85248581
16* MYC_22102868_ChIP-Seq_BL_Human2.80685837
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.80079374
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.79587281
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.73355486
20GATA1_22025678_ChIP-Seq_K562_Human2.69305155
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.66669007
22RUNX_20019798_ChIP-Seq_JUKART_Human2.62415775
23MYB_26560356_Chip-Seq_TH2_Human2.51234039
24MAF_26560356_Chip-Seq_TH1_Human2.43057020
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.42366176
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.42059034
27SPI1_23547873_ChIP-Seq_NB4_Human2.40460405
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.35444971
29MYB_26560356_Chip-Seq_TH1_Human2.33418204
30BRD4_27068464_Chip-Seq_AML-cells_Mouse2.32685247
31* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.18830918
32VDR_24763502_ChIP-Seq_THP-1_Human2.17527688
33* RUNX1_22412390_ChIP-Seq_EML_Mouse2.17141312
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.13253641
35* UTX_26944678_Chip-Seq_JUKART_Human2.11297106
36SPI1_23127762_ChIP-Seq_K562_Human2.06268146
37TCF7_22412390_ChIP-Seq_EML_Mouse2.04106286
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.02845736
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.92553734
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86748029
41FOXM1_23109430_ChIP-Seq_U2OS_Human1.71807014
42* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.70528295
43PU_27001747_Chip-Seq_BMDM_Mouse1.66138744
44* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.63068567
45GATA3_27048872_Chip-Seq_THYMUS_Human1.62578446
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.61970834
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.60731957
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54634502
49PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.54227274
50MAF_26560356_Chip-Seq_TH2_Human1.52311634
51* KDM2B_26808549_Chip-Seq_DND41_Human1.51827016
52* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50115773
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49900819
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.47743309
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45406083
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44494418
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41134972
58CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39575653
59* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38571647
60* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.37983741
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.37418987
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.34879394
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.32853620
64* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32377644
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31983764
66* GATA1_19941827_ChIP-Seq_MEL_Mouse1.30384694
67ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30136690
68CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25257623
69NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.24167968
70* LXR_22292898_ChIP-Seq_THP-1_Human1.20127062
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17019981
72GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15047351
73CIITA_25753668_ChIP-Seq_RAJI_Human1.14831055
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.13666625
75GATA3_26560356_Chip-Seq_TH2_Human1.12839890
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09661836
77PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07231035
78GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05294480
79IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02021926
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01974377
81GATA1_19941826_ChIP-Seq_K562_Human1.01436397
82SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00336522
83TFEB_21752829_ChIP-Seq_HELA_Human1.00019586
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98033589
85VDR_24787735_ChIP-Seq_THP-1_Human0.97140460
86CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96771786
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95715110
88HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94720914
89* GATA2_19941826_ChIP-Seq_K562_Human0.93214635
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93019043
91BCL6_27268052_Chip-Seq_Bcells_Human0.92919756
92STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91332019
93RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90386712
94SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89442506
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88690168
96NCOR1_26117541_ChIP-Seq_K562_Human0.88220328
97E2F4_17652178_ChIP-ChIP_JURKAT_Human0.87902226
98BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.87868301
99BCOR_27268052_Chip-Seq_Bcells_Human0.87727230
100PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86170781
101TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85622590
102CTCF_27219007_Chip-Seq_ERYTHROID_Human0.84527241
103THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83649461
104KDM2B_26808549_Chip-Seq_JURKAT_Human0.82796607
105PU.1_20513432_ChIP-Seq_Bcells_Mouse0.82569868
106EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.81625332
107GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81496353
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75657773
109STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.75622526
110* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74095171
111KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.71633183
112SPI1_20517297_ChIP-Seq_HL60_Human0.71494944
113ETS1_22383799_ChIP-Seq_G1ME_Mouse0.71277415

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.10186538
2MP0000685_abnormal_immune_system3.17907853
3MP0005671_abnormal_response_to3.05584138
4MP0001800_abnormal_humoral_immune2.96915680
5MP0000569_abnormal_digit_pigmentation2.93880444
6MP0001790_abnormal_immune_system2.85878017
7MP0005387_immune_system_phenotype2.85878017
8MP0003436_decreased_susceptibility_to2.79439809
9MP0005000_abnormal_immune_tolerance2.73369522
10MP0002452_abnormal_antigen_presenting2.71048492
11MP0003763_abnormal_thymus_physiology2.59082534
12MP0002723_abnormal_immune_serum2.57996108
13MP0003303_peritoneal_inflammation2.54088306
14MP0002420_abnormal_adaptive_immunity2.53452057
15MP0002396_abnormal_hematopoietic_system2.53160242
16MP0002419_abnormal_innate_immunity2.52253733
17MP0001819_abnormal_immune_cell2.51551917
18MP0005025_abnormal_response_to2.48600707
19MP0009785_altered_susceptibility_to2.35503831
20MP0002398_abnormal_bone_marrow2.34524935
21MP0005464_abnormal_platelet_physiology2.34019357
22MP0002166_altered_tumor_susceptibility2.26742833
23MP0006054_spinal_hemorrhage2.19192169
24MP0002148_abnormal_hypersensitivity_rea2.14223590
25MP0005174_abnormal_tail_pigmentation2.14152884
26MP0000716_abnormal_immune_system2.10654203
27MP0003300_gastrointestinal_ulcer2.08916804
28MP0006082_CNS_inflammation2.06844666
29MP0005058_abnormal_lysosome_morphology2.05119217
30MP0000689_abnormal_spleen_morphology2.04240898
31MP0002405_respiratory_system_inflammati2.04094010
32MP0002722_abnormal_immune_system1.95975739
33MP0004947_skin_inflammation1.93486319
34MP0003172_abnormal_lysosome_physiology1.88505374
35MP0004510_myositis1.88187922
36MP0004808_abnormal_hematopoietic_stem1.83695195
37MP0001873_stomach_inflammation1.82684618
38MP0002006_tumorigenesis1.81508848
39MP0002429_abnormal_blood_cell1.76858462
40MP0009333_abnormal_splenocyte_physiolog1.76270036
41MP0009278_abnormal_bone_marrow1.75990981
42MP0000465_gastrointestinal_hemorrhage1.72858354
43MP0003724_increased_susceptibility_to1.68880359
44MP0010155_abnormal_intestine_physiology1.68494056
45MP0000703_abnormal_thymus_morphology1.67850476
46MP0005397_hematopoietic_system_phenotyp1.66270996
47MP0001545_abnormal_hematopoietic_system1.66270996
48MP0001845_abnormal_inflammatory_respons1.62770542
49MP0005451_abnormal_body_composition1.58936192
50MP0008260_abnormal_autophagy1.55737054
51MP0001853_heart_inflammation1.46906252
52MP0003448_altered_tumor_morphology1.43079937
53MP0000858_altered_metastatic_potential1.37280820
54MP0001533_abnormal_skeleton_physiology1.32817080
55MP0001851_eye_inflammation1.32760426
56MP0000015_abnormal_ear_pigmentation1.32566934
57MP0002933_joint_inflammation1.30893987
58MP0008469_abnormal_protein_level1.30117822
59MP0003183_abnormal_peptide_metabolism1.26188973
60MP0004883_abnormal_blood_vessel1.25234296
61MP0003866_abnormal_defecation1.24334074
62MP0003566_abnormal_cell_adhesion1.21755999
63MP0003690_abnormal_glial_cell1.21474419
64MP0010307_abnormal_tumor_latency1.21204067
65MP0002998_abnormal_bone_remodeling1.20417383
66MP0000490_abnormal_crypts_of1.19650127
67MP0003656_abnormal_erythrocyte_physiolo1.16942764
68MP0001958_emphysema1.16863880
69MP0002132_abnormal_respiratory_system1.10119359
70MP0005310_abnormal_salivary_gland1.05297638
71MP0000343_altered_response_to1.02252066
72MP0001986_abnormal_taste_sensitivity1.01278553
73MP0000604_amyloidosis1.00880571
74MP0003191_abnormal_cellular_cholesterol0.98847008
75MP0005164_abnormal_response_to0.93745392
76MP0005075_abnormal_melanosome_morpholog0.92890238
77MP0000371_diluted_coat_color0.92031272
78MP0008004_abnormal_stomach_pH0.90113775
79MP0005076_abnormal_cell_differentiation0.88849768
80MP0005023_abnormal_wound_healing0.85965394
81MP0002019_abnormal_tumor_incidence0.83552052
82MP0003279_aneurysm0.82002210
83MP0010352_gastrointestinal_tract_polyps0.80726551
84MP0002095_abnormal_skin_pigmentation0.79737963
85MP0001915_intracranial_hemorrhage0.79300283
86MP0003091_abnormal_cell_migration0.77495398
87MP0000249_abnormal_blood_vessel0.77344342
88MP0003828_pulmonary_edema0.76662017
89MP0001663_abnormal_digestive_system0.75468979
90MP0003045_fibrosis0.74712075
91MP0009764_decreased_sensitivity_to0.74639847
92MP0008057_abnormal_DNA_replication0.73308347
93MP0009763_increased_sensitivity_to0.71006074
94MP0008438_abnormal_cutaneous_collagen0.70675481
95MP0001243_abnormal_dermal_layer0.70259456
96MP0004130_abnormal_muscle_cell0.69832148
97MP0003795_abnormal_bone_structure0.68219501
98MP0005166_decreased_susceptibility_to0.65991925
99MP0005390_skeleton_phenotype0.64596532
100MP0000767_abnormal_smooth_muscle0.64248888
101MP0003077_abnormal_cell_cycle0.64139248
102MP0002138_abnormal_hepatobiliary_system0.62785298
103MP0009765_abnormal_xenobiotic_induced0.62685395
104MP0002877_abnormal_melanocyte_morpholog0.58507178
105MP0002928_abnormal_bile_duct0.58197278
106MP0002136_abnormal_kidney_physiology0.57996488
107MP0002009_preneoplasia0.57771232
108MP0009840_abnormal_foam_cell0.57554503
109MP0009115_abnormal_fat_cell0.54502837
110MP0002060_abnormal_skin_morphology0.53627057
111MP0003075_altered_response_to0.52359912
112MP0003453_abnormal_keratinocyte_physiol0.52160025
113MP0004381_abnormal_hair_follicle0.51799521
114MP0005621_abnormal_cell_physiology0.51384871
115MP0008874_decreased_physiological_sensi0.50411147
116MP0002332_abnormal_exercise_endurance0.49580100
117MP0002277_abnormal_respiratory_mucosa0.47541442
118MP0000920_abnormal_myelination0.47382978

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.95288775
2Recurrent bacterial skin infections (HP:0005406)5.65179279
3Eczematoid dermatitis (HP:0000976)4.70616737
4Recurrent viral infections (HP:0004429)4.02433295
5Recurrent fungal infections (HP:0002841)4.02045975
6Absent frontal sinuses (HP:0002688)3.89929378
7Recurrent skin infections (HP:0001581)3.83970538
8Spinal cord lesions (HP:0100561)3.77030523
9Syringomyelia (HP:0003396)3.77030523
10Myositis (HP:0100614)3.69249224
11Elevated erythrocyte sedimentation rate (HP:0003565)3.65028538
12Gastrointestinal infarctions (HP:0005244)3.58532778
13Prostate neoplasm (HP:0100787)3.46659472
14Spondylolisthesis (HP:0003302)3.43164776
15IgM deficiency (HP:0002850)3.39273683
16Recurrent cutaneous fungal infections (HP:0011370)3.38435369
17Chronic mucocutaneous candidiasis (HP:0002728)3.38435369
18T lymphocytopenia (HP:0005403)3.35607440
19Encephalitis (HP:0002383)3.33551270
20Recurrent gram-negative bacterial infections (HP:0005420)3.32708855
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.30930760
22Agnosia (HP:0010524)3.29386695
23Abnormality of macrophages (HP:0004311)3.23471235
24Abnormality of T cell number (HP:0011839)3.21229827
25Chronic otitis media (HP:0000389)3.19028124
26Metaphyseal dysplasia (HP:0100255)3.15270221
27Mediastinal lymphadenopathy (HP:0100721)3.14497637
28Pustule (HP:0200039)3.12915786
29Autoimmune thrombocytopenia (HP:0001973)3.10873866
30Cellulitis (HP:0100658)3.08139739
31Recurrent bronchitis (HP:0002837)3.00834242
32Disinhibition (HP:0000734)2.94624325
33Chronic obstructive pulmonary disease (HP:0006510)2.93087436
34Obstructive lung disease (HP:0006536)2.93087436
35Meningitis (HP:0001287)2.91328626
36Prolonged bleeding time (HP:0003010)2.89205559
37Vacuolated lymphocytes (HP:0001922)2.86680394
38Abnormality of the fingertips (HP:0001211)2.86017423
39Keratoconjunctivitis (HP:0001096)2.83352855
40Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.83251717
41Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.81530405
42Inflammation of the large intestine (HP:0002037)2.79349028
43Gingivitis (HP:0000230)2.79117452
44Stomatitis (HP:0010280)2.78862828
45Urticaria (HP:0001025)2.76566530
46Abnormality of T cells (HP:0002843)2.75524133
47Vasculitis (HP:0002633)2.75267438
48Orchitis (HP:0100796)2.74689680
49Increased cerebral lipofuscin (HP:0011813)2.73323474
50Optic neuritis (HP:0100653)2.72093002
51Retrobulbar optic neuritis (HP:0100654)2.72093002
52Abnormality of the prostate (HP:0008775)2.71493354
53Periodontitis (HP:0000704)2.70256583
54Gastrointestinal inflammation (HP:0004386)2.69626888
55Colitis (HP:0002583)2.67802233
56Thrombocytosis (HP:0001894)2.66399617
57Spontaneous hematomas (HP:0007420)2.64164741
58Agammaglobulinemia (HP:0004432)2.62812388
59Panhypogammaglobulinemia (HP:0003139)2.59151900
60Nasal polyposis (HP:0100582)2.48028802
61Epistaxis (HP:0000421)2.47035163
62Leukocytosis (HP:0001974)2.44325903
63Abnormality of T cell physiology (HP:0011840)2.39684060
64Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.35984795
65Arterial thrombosis (HP:0004420)2.35516251
66Abnormality of the frontal sinuses (HP:0002687)2.35373805
67Interstitial pulmonary disease (HP:0006530)2.35053162
68Abnormal platelet function (HP:0011869)2.33998692
69Impaired platelet aggregation (HP:0003540)2.33998692
70Increased IgM level (HP:0003496)2.33682362
71Osteomyelitis (HP:0002754)2.33381203
72Increased neuronal autofluorescent lipopigment (HP:0002074)2.31046871
73Petechiae (HP:0000967)2.29734230
74Loss of speech (HP:0002371)2.28803584
75Abnormal platelet volume (HP:0011876)2.27431105
76Viral hepatitis (HP:0006562)2.26405052
77Pulmonary embolism (HP:0002204)2.25521227
78Lymphopenia (HP:0001888)2.25169240
79Myocardial infarction (HP:0001658)2.25030257
80Gingival bleeding (HP:0000225)2.24410936
81Abnormality of the nasal mucosa (HP:0000433)2.23985301
82Pulmonary infiltrates (HP:0002113)2.20041560
83Hemoptysis (HP:0002105)2.19937862
84Increased IgE level (HP:0003212)2.19738000
85Systemic lupus erythematosus (HP:0002725)2.18444147
86Anorexia (HP:0002039)2.17037131
87Amyloidosis (HP:0011034)2.16943035
88Autoimmune hemolytic anemia (HP:0001890)2.16914873
89Abnormality of cells of the lymphoid lineage (HP:0012140)2.16265401
90Eosinophilia (HP:0001880)2.16138895
91Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.15579995
92Increased serum ferritin (HP:0003281)2.15435227
93Episodic fever (HP:0001954)2.14735679
94Hematochezia (HP:0002573)2.11591397
95Hypergammaglobulinemia (HP:0010702)2.10589256
96Emphysema (HP:0002097)2.09860803
97Osteolytic defects of the hand bones (HP:0009699)2.05502491
98Osteolytic defects of the phalanges of the hand (HP:0009771)2.05502491
99Gastrointestinal stroma tumor (HP:0100723)2.05255272
100Thyroiditis (HP:0100646)2.02670354
101Verrucae (HP:0200043)2.01578554
102Papilloma (HP:0012740)2.01578554
103IgG deficiency (HP:0004315)2.00549612
104Chest pain (HP:0100749)1.99305110
105Skin ulcer (HP:0200042)1.98842771
106Keratoconjunctivitis sicca (HP:0001097)1.98733322
107Abnormality of the pleura (HP:0002103)1.97808093
108Sepsis (HP:0100806)1.97516924
109Amaurosis fugax (HP:0100576)1.96119647
110Hypochromic anemia (HP:0001931)1.95677348
111Abnormality of iron homeostasis (HP:0011031)1.95127291
112Granulocytopenia (HP:0001913)1.95023071
113Peritonitis (HP:0002586)1.94272102
114Gangrene (HP:0100758)1.94179001
115Abnormality of eosinophils (HP:0001879)1.93005905
116Delayed closure of the anterior fontanelle (HP:0001476)1.92364204
117Glomerulopathy (HP:0100820)1.91987164
118Dysostosis multiplex (HP:0000943)1.91738601
119Slow saccadic eye movements (HP:0000514)1.91564688
120Restrictive lung disease (HP:0002091)1.90145734
121Hepatosplenomegaly (HP:0001433)1.89666575
122Abnormality of the endocardium (HP:0004306)1.89628646
123Purpura (HP:0000979)1.89572571
124Abnormality of B cell number (HP:0010975)1.89338081
125B lymphocytopenia (HP:0010976)1.89338081
126Abnormality of glycolipid metabolism (HP:0010969)1.89328438
127Abnormality of liposaccharide metabolism (HP:0010968)1.89328438
128Abnormality of glycosphingolipid metabolism (HP:0004343)1.89328438
129Fatigue (HP:0012378)1.89053554
130Cheilitis (HP:0100825)1.87465994
131Polyneuropathy (HP:0001271)1.87265857
132Joint swelling (HP:0001386)1.86567378
133Abnormality of glycosaminoglycan metabolism (HP:0004371)1.85253084

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.84802788
2PRPF4B3.42591004
3JAK33.32206081
4TYK22.90995465
5TXK2.67949859
6KIT2.57450917
7MAP3K142.40427417
8ZAP702.35493835
9IRAK42.29491353
10TBK12.12701592
11BLK2.12665610
12IRAK32.12476241
13STK102.11614756
14IKBKE2.04831332
15JAK11.95885198
16MAP3K131.89111535
17CSF1R1.86496610
18GRK61.86368456
19TAOK31.81786963
20TGFBR21.80819688
21BTK1.79363526
22ITK1.79331838
23RIPK41.68420760
24SIK21.67380875
25SYK1.66574227
26MAP3K101.65069557
27PKN21.60884070
28EEF2K1.56504188
29LCK1.56075967
30IKBKB1.55330503
31HCK1.54353166
32TEC1.52212189
33TTN1.50353234
34FES1.39289600
35CSK1.35829065
36TRIB31.33672317
37LRRK21.30129055
38CDK121.27932636
39FGFR41.26572096
40MAP2K31.24184040
41FLT31.24145473
42CLK11.23908194
43MARK31.23087600
44MAP3K31.22005229
45PIM11.18829513
46ERN11.16262713
47FGFR31.09318243
48BMPR21.06256958
49CDC42BPA1.05070838
50RPS6KA41.04543997
51JAK21.04297116
52NME21.04098818
53TAOK11.02107271
54NEK91.01166817
55LYN1.00618837
56TRPM70.99907990
57MAP3K10.99668047
58MARK20.95087777
59BRD40.95029791
60CAMK1D0.94363459
61KSR20.92620926
62GRK70.92149892
63MAP3K110.90771442
64CHUK0.89013345
65CAMKK20.83290573
66EPHB10.81925152
67CDK60.81643683
68YES10.80512262
69MAP3K80.77526557
70STK40.76323555
71RPS6KA60.76219571
72PIK3CG0.74433852
73PDK10.72349772
74CAMK1G0.71731543
75PTK60.68370900
76RPS6KC10.67436796
77RPS6KL10.67436796
78TAOK20.66328441
79NEK20.66281314
80PRKCQ0.64973031
81IRAK10.64929872
82SMG10.64915763
83TNK20.63408452
84TESK20.61140332
85CAMKK10.60136119
86MOS0.59583028
87PRKCH0.57991616
88CDK40.57816496
89CDK90.56532322
90RPS6KA20.56379203
91PDGFRB0.56077664
92MAP3K60.53515869
93IRAK20.52734976
94NLK0.51557359
95MAPK40.46991369
96RET0.45770679
97ABL10.45437260
98PAK40.45119589
99EGFR0.44963264
100SCYL20.44232137
101MATK0.43962333
102SIK30.43575952
103HIPK20.42535375
104MAP3K70.42116867
105PDPK10.39433739
106MAP3K20.39404110
107MAPKAPK20.39276235
108MELK0.38721349
109ATR0.35552864
110RAF10.35060390
111MAPK110.34993200
112MAPK30.34767893
113SGK30.32662515
114PRKCD0.32578830
115MAP3K50.32319860
116RIPK10.30773618
117FYN0.29258901
118STK240.28832945
119PIM20.28754047
120SIK10.28281953
121KDR0.26630109
122ALK0.25810785
123PRKD20.25508804
124MAPK70.24261540
125FGR0.24256229
126MAPK120.23596753

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.10315689
2Leishmaniasis_Homo sapiens_hsa051402.77995075
3B cell receptor signaling pathway_Homo sapiens_hsa046622.67612070
4Osteoclast differentiation_Homo sapiens_hsa043802.55275652
5Measles_Homo sapiens_hsa051622.44372691
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.38944972
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.24569845
8Antigen processing and presentation_Homo sapiens_hsa046122.12962329
9T cell receptor signaling pathway_Homo sapiens_hsa046602.05293108
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.04882270
11Hematopoietic cell lineage_Homo sapiens_hsa046402.04232868
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.03443558
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.87493344
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.86286106
15Graft-versus-host disease_Homo sapiens_hsa053321.82292539
16Herpes simplex infection_Homo sapiens_hsa051681.71327096
17Type I diabetes mellitus_Homo sapiens_hsa049401.70047518
18Tuberculosis_Homo sapiens_hsa051521.69360691
19Influenza A_Homo sapiens_hsa051641.67170063
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.66363862
21Toxoplasmosis_Homo sapiens_hsa051451.63687653
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.62485006
23Staphylococcus aureus infection_Homo sapiens_hsa051501.61698298
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.55489368
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.51311119
26Malaria_Homo sapiens_hsa051441.50921754
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49929720
28Other glycan degradation_Homo sapiens_hsa005111.48450301
29Apoptosis_Homo sapiens_hsa042101.44639969
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.44525594
31Hepatitis B_Homo sapiens_hsa051611.41004841
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.39863354
33Chronic myeloid leukemia_Homo sapiens_hsa052201.38002587
34Acute myeloid leukemia_Homo sapiens_hsa052211.37666667
35Pertussis_Homo sapiens_hsa051331.37365240
36Viral myocarditis_Homo sapiens_hsa054161.36193814
37Allograft rejection_Homo sapiens_hsa053301.36033426
38Shigellosis_Homo sapiens_hsa051311.35658376
39* Chemokine signaling pathway_Homo sapiens_hsa040621.34313594
40Lysosome_Homo sapiens_hsa041421.34297170
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33647686
42TNF signaling pathway_Homo sapiens_hsa046681.27730354
43* Platelet activation_Homo sapiens_hsa046111.27469589
44Pancreatic cancer_Homo sapiens_hsa052121.26548125
45Legionellosis_Homo sapiens_hsa051341.18314168
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.12435946
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12345149
48Hepatitis C_Homo sapiens_hsa051601.09914600
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07531019
50Salmonella infection_Homo sapiens_hsa051321.06825648
51Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00444538
52Epstein-Barr virus infection_Homo sapiens_hsa051690.95237523
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95013442
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92879499
55Notch signaling pathway_Homo sapiens_hsa043300.90865938
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90514991
57Phagosome_Homo sapiens_hsa041450.86695235
58Small cell lung cancer_Homo sapiens_hsa052220.86387754
59Non-small cell lung cancer_Homo sapiens_hsa052230.82782512
60Viral carcinogenesis_Homo sapiens_hsa052030.82553864
61Rheumatoid arthritis_Homo sapiens_hsa053230.82160464
62Asthma_Homo sapiens_hsa053100.81049604
63* HTLV-I infection_Homo sapiens_hsa051660.80823613
64Caffeine metabolism_Homo sapiens_hsa002320.77854067
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71555674
66DNA replication_Homo sapiens_hsa030300.70469571
67Prolactin signaling pathway_Homo sapiens_hsa049170.67935677
68Base excision repair_Homo sapiens_hsa034100.65742505
69VEGF signaling pathway_Homo sapiens_hsa043700.65537565
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65279295
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65273029
72Autoimmune thyroid disease_Homo sapiens_hsa053200.65194640
73* Phospholipase D signaling pathway_Homo sapiens_hsa040720.65068931
74Choline metabolism in cancer_Homo sapiens_hsa052310.63305007
75Colorectal cancer_Homo sapiens_hsa052100.62745973
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61773731
77Endometrial cancer_Homo sapiens_hsa052130.59576926
78p53 signaling pathway_Homo sapiens_hsa041150.59077475
79Endocytosis_Homo sapiens_hsa041440.56844039
80mTOR signaling pathway_Homo sapiens_hsa041500.55933010
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.55075800
82Insulin resistance_Homo sapiens_hsa049310.54006037
83* GnRH signaling pathway_Homo sapiens_hsa049120.53453809
84HIF-1 signaling pathway_Homo sapiens_hsa040660.52357480
85Inositol phosphate metabolism_Homo sapiens_hsa005620.51602985
86Proteoglycans in cancer_Homo sapiens_hsa052050.50963684
87Type II diabetes mellitus_Homo sapiens_hsa049300.50871548
88Lysine degradation_Homo sapiens_hsa003100.50194232
89MicroRNAs in cancer_Homo sapiens_hsa052060.49765740
90Amoebiasis_Homo sapiens_hsa051460.47149681
91Focal adhesion_Homo sapiens_hsa045100.46615169
92* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46444040
93FoxO signaling pathway_Homo sapiens_hsa040680.44906087
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44667111
95Non-homologous end-joining_Homo sapiens_hsa034500.44400980
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42625216
97Prostate cancer_Homo sapiens_hsa052150.42060296
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41493370
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41237116
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41011988
101ErbB signaling pathway_Homo sapiens_hsa040120.40863930
102African trypanosomiasis_Homo sapiens_hsa051430.38604717
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.38391727
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.37579701
105MAPK signaling pathway_Homo sapiens_hsa040100.35748957
106Mismatch repair_Homo sapiens_hsa034300.35682185
107Glioma_Homo sapiens_hsa052140.34411016
108ABC transporters_Homo sapiens_hsa020100.33167757
109* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32737000
110Dorso-ventral axis formation_Homo sapiens_hsa043200.32368455
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31664143
112* Rap1 signaling pathway_Homo sapiens_hsa040150.30992145
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29796455
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29709875
115Renal cell carcinoma_Homo sapiens_hsa052110.28630121

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