ADCY8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.89057044
2vocalization behavior (GO:0071625)5.75594691
3locomotory exploration behavior (GO:0035641)5.52252417
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.32190723
5synaptic vesicle exocytosis (GO:0016079)5.30798457
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.29871254
7protein localization to synapse (GO:0035418)5.22556840
8glutamate secretion (GO:0014047)5.13016803
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.09567838
10synaptic vesicle maturation (GO:0016188)5.08743133
11L-amino acid import (GO:0043092)5.03967755
12ionotropic glutamate receptor signaling pathway (GO:0035235)5.00120128
13neuron cell-cell adhesion (GO:0007158)4.93251789
14regulation of glutamate receptor signaling pathway (GO:1900449)4.83666320
15regulation of synaptic vesicle exocytosis (GO:2000300)4.74864700
16central nervous system myelination (GO:0022010)4.68058145
17axon ensheathment in central nervous system (GO:0032291)4.68058145
18glutamate receptor signaling pathway (GO:0007215)4.65184999
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.61772550
20amino acid import (GO:0043090)4.57894372
21synaptic vesicle docking involved in exocytosis (GO:0016081)4.51088993
22synaptic transmission, glutamatergic (GO:0035249)4.44113771
23cellular potassium ion homeostasis (GO:0030007)4.43454411
24neurotransmitter-gated ion channel clustering (GO:0072578)4.42405983
25exploration behavior (GO:0035640)4.34836207
26neurotransmitter secretion (GO:0007269)4.33890120
27gamma-aminobutyric acid transport (GO:0015812)4.27775553
28layer formation in cerebral cortex (GO:0021819)4.25852753
29neuronal action potential propagation (GO:0019227)4.23883723
30neuron-neuron synaptic transmission (GO:0007270)4.19836564
31regulation of synaptic vesicle transport (GO:1902803)4.18674406
32regulation of long-term neuronal synaptic plasticity (GO:0048169)4.17604894
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.12866760
34postsynaptic membrane organization (GO:0001941)3.96284046
35potassium ion import (GO:0010107)3.95992118
36positive regulation of synapse maturation (GO:0090129)3.94991248
37neuron recognition (GO:0008038)3.94583847
38neurotransmitter uptake (GO:0001504)3.94336363
39proline transport (GO:0015824)3.92185351
40regulation of neuronal synaptic plasticity (GO:0048168)3.90693271
41G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.87460040
42gamma-aminobutyric acid signaling pathway (GO:0007214)3.84534254
43presynaptic membrane assembly (GO:0097105)3.80781863
44regulation of excitatory postsynaptic membrane potential (GO:0060079)3.76843758
45sodium ion export (GO:0071436)3.73171568
46regulation of postsynaptic membrane potential (GO:0060078)3.70238428
47axonal fasciculation (GO:0007413)3.69593020
48cerebellar granule cell differentiation (GO:0021707)3.67047739
49synaptic vesicle endocytosis (GO:0048488)3.66801869
50* long-term memory (GO:0007616)3.63601059
51positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.63473512
52dendritic spine morphogenesis (GO:0060997)3.63070887
53behavioral fear response (GO:0001662)3.60619740
54behavioral defense response (GO:0002209)3.60619740
55neurotransmitter transport (GO:0006836)3.57176276
56cerebellar Purkinje cell differentiation (GO:0021702)3.56046303
57presynaptic membrane organization (GO:0097090)3.55722431
58positive regulation of membrane potential (GO:0045838)3.52371838
59fear response (GO:0042596)3.52363784
60negative regulation of synaptic transmission, GABAergic (GO:0032229)3.46266692
61astrocyte differentiation (GO:0048708)3.45326169
62membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.44338724
63pyrimidine nucleobase catabolic process (GO:0006208)3.44069875
64regulation of synaptic transmission, glutamatergic (GO:0051966)3.43066049
65cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.41265730
66regulation of neurotransmitter secretion (GO:0046928)3.41223008
67dermatan sulfate biosynthetic process (GO:0030208)3.35791597
68membrane assembly (GO:0071709)3.33451323
69membrane hyperpolarization (GO:0060081)3.32893332
70response to histamine (GO:0034776)3.30426921
71neuromuscular process controlling posture (GO:0050884)3.29622906
72regulation of synaptic plasticity (GO:0048167)3.28455264
73long-term synaptic potentiation (GO:0060291)3.26707240
74regulation of neurotransmitter levels (GO:0001505)3.25445142
75acidic amino acid transport (GO:0015800)3.25149387
76neuron projection regeneration (GO:0031102)3.24309946
77neuronal ion channel clustering (GO:0045161)3.24264599
78response to auditory stimulus (GO:0010996)3.23637613
79* activation of protein kinase A activity (GO:0034199)3.22064396
80auditory behavior (GO:0031223)3.21835255
81cell communication by electrical coupling (GO:0010644)3.21306888
82positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.20501319
83regulation of respiratory system process (GO:0044065)3.19911228
84response to pheromone (GO:0019236)3.19740152
85regulation of synapse structural plasticity (GO:0051823)3.18590617
86innervation (GO:0060384)3.18040026
87positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.17334772
88transmission of nerve impulse (GO:0019226)3.16797531
89regulation of vesicle fusion (GO:0031338)3.16725461
90regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.13755332
91astrocyte development (GO:0014002)3.13718179
92response to dietary excess (GO:0002021)3.13089678
93membrane depolarization (GO:0051899)3.12300120
94glycine transport (GO:0015816)3.09465962
95regulation of synapse maturation (GO:0090128)3.08497143
96regulation of dendritic spine morphogenesis (GO:0061001)3.07249661
97dendrite morphogenesis (GO:0048813)3.06863855
98regulation of neurotransmitter transport (GO:0051588)3.05569414
99dermatan sulfate metabolic process (GO:0030205)3.04744212
100synapse assembly (GO:0007416)3.03887439
101establishment of mitochondrion localization (GO:0051654)3.03225742
102positive regulation of synaptic transmission, GABAergic (GO:0032230)3.03077069
103membrane depolarization during action potential (GO:0086010)3.01803568
104positive regulation of neurotransmitter secretion (GO:0001956)3.01457777
105neuromuscular process controlling balance (GO:0050885)2.99458937
106social behavior (GO:0035176)2.98336388
107intraspecies interaction between organisms (GO:0051703)2.98336388
108negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.98176414
109* synaptic transmission (GO:0007268)2.97643861
110learning (GO:0007612)2.97601984
111L-glutamate transport (GO:0015813)2.97325455
112negative regulation of cytosolic calcium ion concentration (GO:0051481)2.93806926
113cAMP-mediated signaling (GO:0019933)2.93781135
114cellular sodium ion homeostasis (GO:0006883)2.93586014
115startle response (GO:0001964)2.92912591
116positive regulation of synapse assembly (GO:0051965)2.91387524
117neuromuscular synaptic transmission (GO:0007274)2.89109447
118regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.88704192
119mechanosensory behavior (GO:0007638)2.88184915
120regulation of synaptic transmission (GO:0050804)2.88179995
121potassium ion homeostasis (GO:0055075)2.86927339
122positive regulation of potassium ion transmembrane transport (GO:1901381)2.85169825
123positive regulation of synaptic transmission (GO:0050806)2.85083432
124one-carbon compound transport (GO:0019755)2.84862011
125cyclic-nucleotide-mediated signaling (GO:0019935)2.82650065
126cGMP-mediated signaling (GO:0019934)2.75575927
127cerebellar Purkinje cell layer development (GO:0021680)2.75040059
128axon regeneration (GO:0031103)2.74235401
129cell migration in hindbrain (GO:0021535)2.73515277
130regulation of respiratory gaseous exchange (GO:0043576)2.72236925
131positive regulation of dendritic spine development (GO:0060999)2.71597987
132myelination (GO:0042552)2.70974446
133adult walking behavior (GO:0007628)2.70920017

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.67627569
2* GBX2_23144817_ChIP-Seq_PC3_Human3.81857427
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08406917
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.07336980
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03311923
6* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67867421
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67867421
8* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60858519
9* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.57375895
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57215678
11REST_21632747_ChIP-Seq_MESCs_Mouse2.51457496
12* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47922021
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45154555
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41593616
15* EZH2_27304074_Chip-Seq_ESCs_Mouse2.39916050
16* EED_16625203_ChIP-ChIP_MESCs_Mouse2.39669197
17DROSHA_22980978_ChIP-Seq_HELA_Human2.34101189
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29575692
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.19938789
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.14964933
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10918369
22* RNF2_27304074_Chip-Seq_ESCs_Mouse2.10252023
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.06768178
24* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04926176
25RARB_27405468_Chip-Seq_BRAIN_Mouse2.04297630
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.99540801
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.98388572
28TAF15_26573619_Chip-Seq_HEK293_Human1.97367953
29AR_21572438_ChIP-Seq_LNCaP_Human1.94647893
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.90579390
31* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81343791
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74604833
33SMAD4_21799915_ChIP-Seq_A2780_Human1.71599908
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.68954662
35* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68922483
36SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.62783964
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59760791
38RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.59585873
39* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55265302
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50551999
41* P300_19829295_ChIP-Seq_ESCs_Human1.47070225
42EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44252625
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.42217512
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.40634675
45* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40165101
46ZNF274_21170338_ChIP-Seq_K562_Hela1.40065488
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.38062730
48* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37547447
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.37019692
50* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36785394
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36768654
52AR_25329375_ChIP-Seq_VCAP_Human1.36541903
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.35738657
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34767149
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.34273026
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32686471
57* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29126655
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27394200
59* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27107801
60RING1B_27294783_Chip-Seq_ESCs_Mouse1.26147523
61TP53_16413492_ChIP-PET_HCT116_Human1.23741354
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23664658
63* STAT3_23295773_ChIP-Seq_U87_Human1.22696636
64* AR_19668381_ChIP-Seq_PC3_Human1.21650372
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21179236
66ARNT_22903824_ChIP-Seq_MCF-7_Human1.20813823
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20518925
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18179040
69* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17937054
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17377028
71* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17035159
72IGF1R_20145208_ChIP-Seq_DFB_Human1.15708779
73STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14803880
74OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13471611
75RNF2_27304074_Chip-Seq_NSC_Mouse1.13327962
76AHR_22903824_ChIP-Seq_MCF-7_Human1.13131420
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12107532
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10838818
79TCF4_23295773_ChIP-Seq_U87_Human1.09936535
80RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08696759
81WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08216154
82FUS_26573619_Chip-Seq_HEK293_Human1.07978112
83GATA1_26923725_Chip-Seq_HPCs_Mouse1.07806392
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06586273
85YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05377286
86TP53_18474530_ChIP-ChIP_U2OS_Human1.05309650
87MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03113705
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02496491
89LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01672339
90VDR_22108803_ChIP-Seq_LS180_Human1.01274500
91RUNX2_22187159_ChIP-Seq_PCA_Human1.01167318
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00997378
93SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00756197
94* RING1B_27294783_Chip-Seq_NPCs_Mouse1.00723062
95DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00285739
96ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00245288
97KDM2B_26808549_Chip-Seq_K562_Human1.00216423
98EP300_21415370_ChIP-Seq_HL-1_Mouse0.99462953
99SOX9_26525672_Chip-Seq_HEART_Mouse0.99212567
100BCAT_22108803_ChIP-Seq_LS180_Human0.99168560
101PRDM14_20953172_ChIP-Seq_ESCs_Human0.98707432
102ISL1_27105846_Chip-Seq_CPCs_Mouse0.98456537
103KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97990757
104TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97511305
105SMAD4_21741376_ChIP-Seq_HESCs_Human0.97012203
106ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96828678
107* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96145235
108RXR_22108803_ChIP-Seq_LS180_Human0.95977466
109TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95768154
110* TP53_20018659_ChIP-ChIP_R1E_Mouse0.95060055
111SMAD3_21741376_ChIP-Seq_ESCs_Human0.94991317
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94630239
113SMAD3_21741376_ChIP-Seq_HESCs_Human0.93720422
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92145928
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92145928
116ER_23166858_ChIP-Seq_MCF-7_Human0.91115601
117* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91100948
118TRIM28_21343339_ChIP-Seq_HEK293_Human0.90634913
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90578037
120* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89943402
121TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88662005
122ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88322617
123WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87797492
124NANOG_18555785_Chip-Seq_ESCs_Mouse0.85355022

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.05040839
2MP0003880_abnormal_central_pattern5.16477365
3* MP0003635_abnormal_synaptic_transmissio4.10620111
4MP0003136_yellow_coat_color3.67998235
5MP0004270_analgesia3.63102656
6MP0009745_abnormal_behavioral_response3.48390594
7MP0009046_muscle_twitch3.33711188
8MP0002063_abnormal_learning/memory/cond3.26053479
9MP0002064_seizures3.25101521
10MP0001968_abnormal_touch/_nociception2.98198521
11MP0005423_abnormal_somatic_nervous2.96910513
12* MP0002572_abnormal_emotion/affect_behav2.80790334
13MP0002734_abnormal_mechanical_nocicepti2.66479696
14MP0005171_absent_coat_pigmentation2.65733819
15* MP0002272_abnormal_nervous_system2.64602339
16MP0001501_abnormal_sleep_pattern2.56109510
17MP0001486_abnormal_startle_reflex2.52617689
18MP0001440_abnormal_grooming_behavior2.43678819
19MP0002736_abnormal_nociception_after2.29327283
20MP0002653_abnormal_ependyma_morphology2.25152253
21* MP0002735_abnormal_chemical_nociception2.15121280
22MP0002067_abnormal_sensory_capabilities2.13822547
23MP0002733_abnormal_thermal_nociception2.02878916
24MP0003329_amyloid_beta_deposits1.95915540
25MP0004858_abnormal_nervous_system1.90425028
26MP0000778_abnormal_nervous_system1.90388265
27MP0008569_lethality_at_weaning1.89314964
28MP0002184_abnormal_innervation1.88055233
29* MP0001970_abnormal_pain_threshold1.86958043
30MP0002557_abnormal_social/conspecific_i1.85964734
31MP0003787_abnormal_imprinting1.78600925
32MP0009780_abnormal_chondrocyte_physiolo1.78390746
33MP0003879_abnormal_hair_cell1.77527496
34MP0006276_abnormal_autonomic_nervous1.65519259
35MP0005646_abnormal_pituitary_gland1.63490592
36MP0000955_abnormal_spinal_cord1.58401122
37MP0004811_abnormal_neuron_physiology1.57319109
38MP0004924_abnormal_behavior1.56440649
39MP0005386_behavior/neurological_phenoty1.56440649
40MP0003633_abnormal_nervous_system1.43636079
41MP0002882_abnormal_neuron_morphology1.42451802
42MP0004885_abnormal_endolymph1.41393233
43MP0002066_abnormal_motor_capabilities/c1.41091633
44MP0002909_abnormal_adrenal_gland1.40690411
45MP0003122_maternal_imprinting1.38975872
46MP0004142_abnormal_muscle_tone1.37428744
47MP0001984_abnormal_olfaction1.35916904
48MP0005645_abnormal_hypothalamus_physiol1.33831696
49MP0001502_abnormal_circadian_rhythm1.31231371
50MP0002822_catalepsy1.24842006
51MP0005551_abnormal_eye_electrophysiolog1.23543629
52MP0003631_nervous_system_phenotype1.17839670
53MP0001188_hyperpigmentation1.16947180
54MP0000579_abnormal_nail_morphology1.14222902
55MP0004145_abnormal_muscle_electrophysio1.13979627
56MP0010386_abnormal_urinary_bladder1.12110408
57MP0002152_abnormal_brain_morphology1.09857470
58MP0003890_abnormal_embryonic-extraembry1.04920346
59MP0000751_myopathy1.04900705
60MP0005623_abnormal_meninges_morphology1.04139109
61MP0004742_abnormal_vestibular_system1.02286218
62MP0002229_neurodegeneration0.99780831
63MP0008872_abnormal_physiological_respon0.95724411
64MP0001905_abnormal_dopamine_level0.93511730
65MP0001529_abnormal_vocalization0.93141278
66MP0001963_abnormal_hearing_physiology0.91793254
67MP0000534_abnormal_ureter_morphology0.91511074
68MP0003690_abnormal_glial_cell0.89231651
69MP0002069_abnormal_eating/drinking_beha0.88154231
70MP0004215_abnormal_myocardial_fiber0.87858136
71MP0003283_abnormal_digestive_organ0.86947150
72MP0002837_dystrophic_cardiac_calcinosis0.85757196
73MP0003634_abnormal_glial_cell0.85574757
74MP0001177_atelectasis0.85488362
75MP0004085_abnormal_heartbeat0.85167869
76MP0000604_amyloidosis0.84217081
77MP0004484_altered_response_of0.83700842
78MP0005167_abnormal_blood-brain_barrier0.80507360
79MP0002752_abnormal_somatic_nervous0.80036262
80MP0000631_abnormal_neuroendocrine_gland0.79542260
81MP0003632_abnormal_nervous_system0.79404378
82MP0005394_taste/olfaction_phenotype0.78967014
83MP0005499_abnormal_olfactory_system0.78967014
84MP0008874_decreased_physiological_sensi0.78805193
85MP0003137_abnormal_impulse_conducting0.77535236
86MP0005187_abnormal_penis_morphology0.77467141
87MP0008961_abnormal_basal_metabolism0.77247016
88MP0003938_abnormal_ear_development0.77213651
89MP0000569_abnormal_digit_pigmentation0.76782415
90MP0002876_abnormal_thyroid_physiology0.76039611
91MP0002090_abnormal_vision0.75607427
92MP0004233_abnormal_muscle_weight0.73871582
93MP0000462_abnormal_digestive_system0.73664362
94MP0003119_abnormal_digestive_system0.72489549
95MP0004133_heterotaxia0.72315170
96MP0001664_abnormal_digestion0.71207215
97MP0005535_abnormal_body_temperature0.70921519
98MP0000920_abnormal_myelination0.68991768
99MP0000537_abnormal_urethra_morphology0.67167927
100MP0000013_abnormal_adipose_tissue0.66461250
101MP0010769_abnormal_survival0.64454030
102MP0003075_altered_response_to0.64063446
103MP0002638_abnormal_pupillary_reflex0.63859856
104MP0003123_paternal_imprinting0.62973102
105MP0001485_abnormal_pinna_reflex0.62775723
106MP0001943_abnormal_respiration0.62646836
107MP0002249_abnormal_larynx_morphology0.62166210
108MP0006072_abnormal_retinal_apoptosis0.61270021
109MP0002082_postnatal_lethality0.61108487
110MP0000026_abnormal_inner_ear0.60717757
111MP0000566_synostosis0.59738730
112MP0010768_mortality/aging0.59702337
113MP0003121_genomic_imprinting0.59596677
114MP0001346_abnormal_lacrimal_gland0.59532127
115MP0004043_abnormal_pH_regulation0.58684749
116MP0005253_abnormal_eye_physiology0.57620684
117MP0005595_abnormal_vascular_smooth0.57118691
118MP0005248_abnormal_Harderian_gland0.56668217
119MP0002081_perinatal_lethality0.55956906
120MP0003861_abnormal_nervous_system0.55583312
121MP0009379_abnormal_foot_pigmentation0.55185752
122MP0001299_abnormal_eye_distance/0.54678966
123MP0003045_fibrosis0.54054894
124MP0010770_preweaning_lethality0.53704467

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.32910096
2Myokymia (HP:0002411)6.24620299
3Focal seizures (HP:0007359)6.00227932
4Epileptic encephalopathy (HP:0200134)5.52847053
5Atonic seizures (HP:0010819)5.36863229
6Visual hallucinations (HP:0002367)5.33726706
7Febrile seizures (HP:0002373)4.88436477
8Progressive cerebellar ataxia (HP:0002073)4.85641425
9Absence seizures (HP:0002121)4.70827449
10Dialeptic seizures (HP:0011146)4.25748431
11Generalized tonic-clonic seizures (HP:0002069)4.08492665
12Action tremor (HP:0002345)3.87902807
13Hyperventilation (HP:0002883)3.87485227
14Broad-based gait (HP:0002136)3.73506361
15Peripheral hypomyelination (HP:0007182)3.63571276
16Split foot (HP:0001839)3.40626461
17Supranuclear gaze palsy (HP:0000605)3.34216446
18Gaze-evoked nystagmus (HP:0000640)3.33609073
19Dysdiadochokinesis (HP:0002075)3.28088722
20Abnormal eating behavior (HP:0100738)3.16337648
21Poor eye contact (HP:0000817)3.15041255
22Impaired vibration sensation in the lower limbs (HP:0002166)3.13360687
23Genetic anticipation (HP:0003743)3.10231466
24Hemiparesis (HP:0001269)3.03437303
25Drooling (HP:0002307)3.01501211
26Excessive salivation (HP:0003781)3.01501211
27Dysmetria (HP:0001310)3.00238954
28Mutism (HP:0002300)2.99570132
29Urinary bladder sphincter dysfunction (HP:0002839)2.99533734
30Truncal ataxia (HP:0002078)2.98784901
31Impaired social interactions (HP:0000735)2.96752319
32Abnormal social behavior (HP:0012433)2.96752319
33Abnormality of binocular vision (HP:0011514)2.96209811
34Diplopia (HP:0000651)2.96209811
35Depression (HP:0000716)2.87619450
36Hemiplegia (HP:0002301)2.84900984
37Insomnia (HP:0100785)2.82117425
38Amblyopia (HP:0000646)2.78037906
39Ulnar claw (HP:0001178)2.75437809
40Postural instability (HP:0002172)2.73504607
41Ankle clonus (HP:0011448)2.71020105
42Neurofibrillary tangles (HP:0002185)2.68631948
43Cerebral inclusion bodies (HP:0100314)2.68541578
44Polyphagia (HP:0002591)2.68432993
45Overriding aorta (HP:0002623)2.67464683
46Impaired smooth pursuit (HP:0007772)2.66670707
47Papilledema (HP:0001085)2.58636891
48Status epilepticus (HP:0002133)2.52358015
49Dysmetric saccades (HP:0000641)2.52288323
50Hammertoe (HP:0001765)2.51952273
51Increased circulating renin level (HP:0000848)2.50237622
52Abnormality of the diencephalon (HP:0010662)2.49993445
53Anxiety (HP:0000739)2.46967772
54Epileptiform EEG discharges (HP:0011182)2.45947226
55Megalencephaly (HP:0001355)2.45214428
56Abnormality of the corticospinal tract (HP:0002492)2.44867628
57Agitation (HP:0000713)2.44253469
58Progressive inability to walk (HP:0002505)2.43558299
59Scanning speech (HP:0002168)2.42028073
60Elfin facies (HP:0004428)2.37561794
61Termporal pattern (HP:0011008)2.36448488
62Insidious onset (HP:0003587)2.36448488
63Fetal akinesia sequence (HP:0001989)2.34286123
64Urethral obstruction (HP:0000796)2.33137543
65Hyperacusis (HP:0010780)2.32809892
66EEG with generalized epileptiform discharges (HP:0011198)2.29248399
67Absent speech (HP:0001344)2.27868923
68Inability to walk (HP:0002540)2.27817639
69Stereotypic behavior (HP:0000733)2.27306470
70Abnormality of ocular smooth pursuit (HP:0000617)2.26600839
71Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.24615027
72Turricephaly (HP:0000262)2.24187449
73Cutaneous finger syndactyly (HP:0010554)2.21152848
74Intention tremor (HP:0002080)2.17746333
75Renovascular hypertension (HP:0100817)2.16189926
76Bradykinesia (HP:0002067)2.14640631
77Urinary urgency (HP:0000012)2.13858636
78Spastic gait (HP:0002064)2.13606223
79Abnormality of the lower motor neuron (HP:0002366)2.11997833
80Impaired vibratory sensation (HP:0002495)2.10167828
81Aplasia involving bones of the extremities (HP:0009825)2.08178501
82Aplasia involving bones of the upper limbs (HP:0009823)2.08178501
83Aplasia of the phalanges of the hand (HP:0009802)2.08178501
84Abnormality of salivation (HP:0100755)2.06137063
85Bronchomalacia (HP:0002780)2.05912114
86Decreased motor nerve conduction velocity (HP:0003431)2.04803507
87Anomalous pulmonary venous return (HP:0010772)2.04291046
88Protruding tongue (HP:0010808)2.03126955
89Hypsarrhythmia (HP:0002521)2.02893465
90Cutaneous syndactyly (HP:0012725)2.02769731
91Generalized myoclonic seizures (HP:0002123)2.01531977
92Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.01333781
93Degeneration of the lateral corticospinal tracts (HP:0002314)2.01195843
94Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.01195843
95Ventricular fibrillation (HP:0001663)1.99532895
96Amyotrophic lateral sclerosis (HP:0007354)1.98572696
97Gait ataxia (HP:0002066)1.97703100
98Abnormality of the 4th metacarpal (HP:0010012)1.95990555
99Obstructive sleep apnea (HP:0002870)1.95365361
100Foot dorsiflexor weakness (HP:0009027)1.94110491
101Neuronal loss in central nervous system (HP:0002529)1.92637607
102Torticollis (HP:0000473)1.91947243
103Focal dystonia (HP:0004373)1.91786404
104Lower limb amyotrophy (HP:0007210)1.91069981
105Renal duplication (HP:0000075)1.89665267
106Blue irides (HP:0000635)1.89649721
107Hypoglycemic seizures (HP:0002173)1.88684745
108Abnormality of the foot musculature (HP:0001436)1.88407422
109Spastic tetraparesis (HP:0001285)1.87869182
110Psychosis (HP:0000709)1.87330451
111Pheochromocytoma (HP:0002666)1.86225954
112Lower limb muscle weakness (HP:0007340)1.86158960
113Dynein arm defect of respiratory motile cilia (HP:0012255)1.83930492
114Absent/shortened dynein arms (HP:0200106)1.83930492
115Onion bulb formation (HP:0003383)1.83318388
116Neoplasm of the heart (HP:0100544)1.82038472
117Limb dystonia (HP:0002451)1.79894477
118Incomplete penetrance (HP:0003829)1.79068609
119Abnormality of saccadic eye movements (HP:0000570)1.78521407
120Sleep apnea (HP:0010535)1.76211696
121Narrow nasal bridge (HP:0000446)1.74974468
122Morphological abnormality of the pyramidal tract (HP:0002062)1.74943688
123Abnormality of the pulmonary veins (HP:0011718)1.74555470
124Vertebral arch anomaly (HP:0008438)1.74447658
125Gait imbalance (HP:0002141)1.74049239
126Synostosis of carpal bones (HP:0005048)1.73513403
127Tetraplegia (HP:0002445)1.72712486
128Aqueductal stenosis (HP:0002410)1.71252348
129Shallow orbits (HP:0000586)1.70998650
130Steppage gait (HP:0003376)1.70539701
131Specific learning disability (HP:0001328)1.69349077
132Hypoventilation (HP:0002791)1.69100565
133Nuclear cataract (HP:0100018)1.68749879
134Abnormal ciliary motility (HP:0012262)1.68329542
135Apathy (HP:0000741)1.67618865
136Morphological abnormality of the inner ear (HP:0011390)1.66924697
137Widely spaced teeth (HP:0000687)1.66540518
138Inappropriate behavior (HP:0000719)1.66183499
139Hypoplasia of the corpus callosum (HP:0002079)1.65764510
140Akinesia (HP:0002304)1.63963310
141Flat cornea (HP:0007720)1.63238024
142Rigidity (HP:0002063)1.61476939
143Annular pancreas (HP:0001734)1.58330646

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.20329154
2CASK3.60626248
3MAP3K93.55812504
4MARK13.50731252
5EPHA43.48106795
6MAP3K43.19010104
7LATS12.83398248
8MAP2K72.72611120
9MINK12.51536199
10DAPK22.37224637
11NTRK22.34216414
12STK38L2.28884578
13MAP3K122.12070483
14PAK62.06282313
15RIPK41.96911186
16MAP2K41.95139222
17NTRK11.82227919
18PRKD31.79368802
19MAPK131.76566461
20PLK21.72707582
21TNIK1.66820991
22KSR21.56689835
23CAMKK11.48698463
24SIK21.48346572
25CDK51.46858453
26CDK191.46520825
27DAPK11.46393446
28GRK51.45006847
29KSR11.39853481
30PRKCG1.33809350
31PNCK1.29390144
32PHKG11.28407612
33PHKG21.28407612
34STK381.22218866
35PINK11.17881422
36LATS21.16828951
37CAMK2A1.11343753
38FGFR21.10124531
39FES1.05633516
40SGK4941.05160910
41SGK2231.05160910
42CAMKK21.01376562
43LMTK20.99963521
44TAOK10.98088933
45PDGFRA0.96962442
46CDK180.94470273
47UHMK10.93603064
48CDK140.92891287
49CDK150.92608467
50DYRK20.92385199
51CAMK10.91439800
52MAP3K130.90040124
53CAMK2B0.89442363
54EPHA30.87500333
55MOS0.85728141
56NEK60.85235484
57SGK20.84244989
58PRPF4B0.84203161
59STK110.84122575
60PAK30.82329553
61TYRO30.81260275
62PRKCH0.81007113
63CDK11A0.80505713
64AKT30.79536151
65OXSR10.77562081
66CCNB10.76929877
67ARAF0.76292892
68FER0.75463098
69BMPR20.74116532
70ERBB40.72507179
71DYRK1A0.71621166
72SGK10.70299184
73MAP3K20.69644744
74MARK20.69477841
75PRKCE0.67939188
76CSNK1A1L0.67822817
77CSNK1G20.67815657
78ROCK10.64461209
79ALK0.63032623
80CAMK1G0.62919700
81PTK2B0.62146541
82RET0.62029663
83SGK30.60678263
84NME10.58499674
85CAMK2G0.58328313
86ERBB20.57949709
87CAMK2D0.57906951
88CDK30.57792442
89TNK20.56171786
90CDC42BPA0.55202481
91MAPK120.54232775
92PDGFRB0.52858247
93BMPR1B0.51135544
94RPS6KB10.49275427
95WNK10.49175675
96PRKCZ0.48377511
97ROCK20.48249194
98MAP3K70.48000126
99FGR0.47270308
100RAF10.46921032
101RPS6KA30.46884581
102CSNK1D0.46698625
103BMX0.46545778
104MAP3K60.46466814
105PDK10.45052684
106FYN0.44307048
107SIK30.43690057
108DMPK0.43674005
109RIPK10.42987994
110MELK0.42267095
111MAPK100.42106578
112CAMK40.41886367
113PKN10.41368686
114CSNK1G10.40688186
115BCR0.39497635
116MUSK0.39351836
117MAP2K10.38963228
118WNK30.38815042
119PRKDC0.38804727
120PDPK10.37689498
121PRKG10.37454141
122RPS6KA20.37064878
123DAPK30.36260671
124CSNK1G30.35687434
125MAP3K10.35161510
126PRKCA0.34513821
127PRKCB0.33336200
128PRKD10.31900931
129CAMK1D0.30913736
130ERBB30.30839996
131TSSK60.29031389
132GSK3B0.25684187

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.13531621
2Synaptic vesicle cycle_Homo sapiens_hsa047213.19661699
3* GABAergic synapse_Homo sapiens_hsa047272.79858052
4* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.76371641
5* Circadian entrainment_Homo sapiens_hsa047132.69660541
6* Glutamatergic synapse_Homo sapiens_hsa047242.67236227
7* Long-term potentiation_Homo sapiens_hsa047202.62063021
8* Morphine addiction_Homo sapiens_hsa050322.48099580
9* Salivary secretion_Homo sapiens_hsa049702.35997660
10Amphetamine addiction_Homo sapiens_hsa050312.31874638
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.29173596
12Olfactory transduction_Homo sapiens_hsa047402.24636890
13* Insulin secretion_Homo sapiens_hsa049112.02178883
14Dopaminergic synapse_Homo sapiens_hsa047282.01727832
15Long-term depression_Homo sapiens_hsa047301.90343183
16* Gastric acid secretion_Homo sapiens_hsa049711.89079128
17* Taste transduction_Homo sapiens_hsa047421.88210372
18Renin secretion_Homo sapiens_hsa049241.81955802
19* Cholinergic synapse_Homo sapiens_hsa047251.76223794
20Serotonergic synapse_Homo sapiens_hsa047261.71832480
21* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.70448087
22* Oxytocin signaling pathway_Homo sapiens_hsa049211.57013285
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.56077592
24* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55969804
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54993007
26* Calcium signaling pathway_Homo sapiens_hsa040201.54688476
27Collecting duct acid secretion_Homo sapiens_hsa049661.49974491
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44301088
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42800968
30Cocaine addiction_Homo sapiens_hsa050301.39327431
31* GnRH signaling pathway_Homo sapiens_hsa049121.34204059
32* Gap junction_Homo sapiens_hsa045401.30464878
33* cAMP signaling pathway_Homo sapiens_hsa040241.25598437
34* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21594698
35Axon guidance_Homo sapiens_hsa043601.20054320
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18036968
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14309598
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12554191
39* Estrogen signaling pathway_Homo sapiens_hsa049151.11478507
40Type II diabetes mellitus_Homo sapiens_hsa049301.10024010
41Cardiac muscle contraction_Homo sapiens_hsa042601.07583071
42Hippo signaling pathway_Homo sapiens_hsa043901.06274653
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02285091
44* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00977999
45* Melanogenesis_Homo sapiens_hsa049160.98863485
46Glioma_Homo sapiens_hsa052140.97866099
47Histidine metabolism_Homo sapiens_hsa003400.97436871
48* Pancreatic secretion_Homo sapiens_hsa049720.97113979
49Vibrio cholerae infection_Homo sapiens_hsa051100.95612020
50* Vascular smooth muscle contraction_Homo sapiens_hsa042700.93829487
51ErbB signaling pathway_Homo sapiens_hsa040120.91004425
52Phototransduction_Homo sapiens_hsa047440.89905522
53* Thyroid hormone synthesis_Homo sapiens_hsa049180.87928451
54Vitamin B6 metabolism_Homo sapiens_hsa007500.85155769
55Dorso-ventral axis formation_Homo sapiens_hsa043200.84665708
56* Dilated cardiomyopathy_Homo sapiens_hsa054140.78699712
57beta-Alanine metabolism_Homo sapiens_hsa004100.78148363
58Adherens junction_Homo sapiens_hsa045200.78087692
59Notch signaling pathway_Homo sapiens_hsa043300.77008642
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75208060
61* Oocyte meiosis_Homo sapiens_hsa041140.72159103
62Basal cell carcinoma_Homo sapiens_hsa052170.72122815
63* Phospholipase D signaling pathway_Homo sapiens_hsa040720.71963743
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71872818
65* Bile secretion_Homo sapiens_hsa049760.70677459
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70383701
67* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69273339
68Nitrogen metabolism_Homo sapiens_hsa009100.68746065
69Arginine and proline metabolism_Homo sapiens_hsa003300.68648704
70MAPK signaling pathway_Homo sapiens_hsa040100.67443680
71Choline metabolism in cancer_Homo sapiens_hsa052310.66207967
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65932838
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65843477
74Tight junction_Homo sapiens_hsa045300.63788497
75Colorectal cancer_Homo sapiens_hsa052100.60812589
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60539778
77Ras signaling pathway_Homo sapiens_hsa040140.57975840
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57497876
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56761438
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55127104
81Alzheimers disease_Homo sapiens_hsa050100.54864888
82VEGF signaling pathway_Homo sapiens_hsa043700.54687392
83* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53338615
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52372675
85Hedgehog signaling pathway_Homo sapiens_hsa043400.52354006
86TGF-beta signaling pathway_Homo sapiens_hsa043500.52194039
87Glucagon signaling pathway_Homo sapiens_hsa049220.51862100
88* Rap1 signaling pathway_Homo sapiens_hsa040150.49954701
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.49325128
90Wnt signaling pathway_Homo sapiens_hsa043100.48067399
91Mineral absorption_Homo sapiens_hsa049780.47018816
92Circadian rhythm_Homo sapiens_hsa047100.46988523
93African trypanosomiasis_Homo sapiens_hsa051430.46970075
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.45958688
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45674166
96Sphingolipid metabolism_Homo sapiens_hsa006000.45348876
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.44461391
98AMPK signaling pathway_Homo sapiens_hsa041520.44326086
99Butanoate metabolism_Homo sapiens_hsa006500.44255960
100Inositol phosphate metabolism_Homo sapiens_hsa005620.42013720
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41168867
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39294843
103Fatty acid biosynthesis_Homo sapiens_hsa000610.39106074
104* Ovarian steroidogenesis_Homo sapiens_hsa049130.38415113
105Alcoholism_Homo sapiens_hsa050340.37493031
106Renal cell carcinoma_Homo sapiens_hsa052110.37442418
107Endometrial cancer_Homo sapiens_hsa052130.37032179
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35910150
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35573527
110mTOR signaling pathway_Homo sapiens_hsa041500.34863403
111Endocytosis_Homo sapiens_hsa041440.32434192
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31683915
113* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31490205
114Insulin signaling pathway_Homo sapiens_hsa049100.31401081
115Oxidative phosphorylation_Homo sapiens_hsa001900.30200510
116Prion diseases_Homo sapiens_hsa050200.29252239
117Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29072573
118Type I diabetes mellitus_Homo sapiens_hsa049400.29008179
119* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28278745
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.27147881

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