ADCY9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of somitogenesis (GO:0014807)7.82579918
2positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.15293568
3negative regulation of catenin import into nucleus (GO:0035414)5.07137622
4replicative senescence (GO:0090399)4.88041293
5tooth mineralization (GO:0034505)4.80761159
6negative regulation of T-helper cell differentiation (GO:0045623)4.62481682
7negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.62481682
8positive regulation of prostaglandin secretion (GO:0032308)4.55328685
9righting reflex (GO:0060013)4.41804650
10regulation of prostaglandin secretion (GO:0032306)4.38886970
11cytoskeletal anchoring at plasma membrane (GO:0007016)4.37464400
12growth hormone receptor signaling pathway (GO:0060396)4.36238099
13regulation of short-term neuronal synaptic plasticity (GO:0048172)4.23539330
14protein K11-linked deubiquitination (GO:0035871)4.20887301
15positive regulation of RNA splicing (GO:0033120)4.06512855
16positive regulation of protein sumoylation (GO:0033235)4.03673663
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.99107256
18regulation of activation of Janus kinase activity (GO:0010533)3.98024302
19ionotropic glutamate receptor signaling pathway (GO:0035235)3.91422046
20locomotory exploration behavior (GO:0035641)3.90835213
21positive regulation of fatty acid biosynthetic process (GO:0045723)3.88881324
22positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.88076756
23vocalization behavior (GO:0071625)3.86434218
24cellular response to growth hormone stimulus (GO:0071378)3.86353305
25detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.85543506
26regulation of DNA damage checkpoint (GO:2000001)3.80994201
27regulation of T-helper 2 cell differentiation (GO:0045628)3.73328116
28neuronal action potential propagation (GO:0019227)3.71529837
29regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.66651748
30positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.64601299
31negative regulation of type 2 immune response (GO:0002829)3.64336368
32synaptic vesicle exocytosis (GO:0016079)3.62134417
33glutamate receptor signaling pathway (GO:0007215)3.60151043
34regulation of endothelial cell differentiation (GO:0045601)3.53922455
35regulation of glutamate receptor signaling pathway (GO:1900449)3.53066776
36negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.52228049
37protein prenylation (GO:0018342)3.46368809
38prenylation (GO:0097354)3.46368809
39positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.46289700
40glutamate secretion (GO:0014047)3.44523353
41synaptic vesicle maturation (GO:0016188)3.40739373
42protein localization to synapse (GO:0035418)3.37617487
43detection of molecule of bacterial origin (GO:0032490)3.37295761
44DNA integration (GO:0015074)3.36130910
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.31488343
46regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.31306693
47negative regulation of actin filament bundle assembly (GO:0032232)3.31121349
48sulfation (GO:0051923)3.30964062
49cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.30371700
50synaptic transmission, glutamatergic (GO:0035249)3.29675240
51hematopoietic stem cell proliferation (GO:0071425)3.28431878
52regulation of long-term neuronal synaptic plasticity (GO:0048169)3.28327496
53regulation of relaxation of muscle (GO:1901077)3.24180920
54leukotriene biosynthetic process (GO:0019370)3.23975758
55response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.23890830
56regulation of neuronal synaptic plasticity (GO:0048168)3.23074206
57regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.20652444
58post-anal tail morphogenesis (GO:0036342)3.20479076
59regulation of synaptic vesicle exocytosis (GO:2000300)3.20236585
60negative regulation of microtubule polymerization (GO:0031115)3.17744297
61synaptic vesicle docking involved in exocytosis (GO:0016081)3.17569811
62positive regulation of icosanoid secretion (GO:0032305)3.17111514
63regulation of synaptic vesicle transport (GO:1902803)3.12652036
64regulation of T-helper 1 cell differentiation (GO:0045625)3.12115082
65regulation of cell communication by electrical coupling (GO:0010649)3.10244305
66chemosensory behavior (GO:0007635)3.09084447
67negative regulation of alpha-beta T cell differentiation (GO:0046639)3.07032230
68neuron-neuron synaptic transmission (GO:0007270)3.06712922
69proline transport (GO:0015824)3.06309570
70exploration behavior (GO:0035640)3.05876734
71negative regulation of vascular permeability (GO:0043116)3.04008569
72long-term memory (GO:0007616)3.03006458
73regulation of excitatory postsynaptic membrane potential (GO:0060079)3.01869931
74detection of calcium ion (GO:0005513)2.99268011
75cellular copper ion homeostasis (GO:0006878)2.95699360
76neurotransmitter-gated ion channel clustering (GO:0072578)2.95188270
77regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.94196620
78cellular potassium ion homeostasis (GO:0030007)2.93863883
79regulation of icosanoid secretion (GO:0032303)2.92630147
80regulation of skeletal muscle contraction (GO:0014819)2.92068308
81regulation of dendritic spine morphogenesis (GO:0061001)2.89752370
82neurotransmitter secretion (GO:0007269)2.89499851
83* cAMP biosynthetic process (GO:0006171)2.89055559
84neuromuscular process controlling posture (GO:0050884)2.88753930
85regulation of synapse structural plasticity (GO:0051823)2.86713231
86response to inactivity (GO:0014854)2.84118771
87positive regulation of synapse maturation (GO:0090129)2.83892736
88regulation of postsynaptic membrane potential (GO:0060078)2.83782774
89L-phenylalanine catabolic process (GO:0006559)2.83074144
90erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.83074144
91cell communication by electrical coupling (GO:0010644)2.82721954
92regulation of synaptic plasticity (GO:0048167)2.80535821
93neuron cell-cell adhesion (GO:0007158)2.79886116
94regulation of actin filament-based movement (GO:1903115)2.79182717
95positive regulation of fatty acid transport (GO:2000193)2.78322968
96gamma-aminobutyric acid transport (GO:0015812)2.77839229
97regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.76173262
98G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.75392871
99* activation of protein kinase A activity (GO:0034199)2.74758850
100negative regulation of cytosolic calcium ion concentration (GO:0051481)2.73625437
101gamma-aminobutyric acid signaling pathway (GO:0007214)2.72432973
102chaperone mediated protein folding requiring cofactor (GO:0051085)2.71973519
103protein targeting to Golgi (GO:0000042)2.70040899
104behavioral fear response (GO:0001662)2.69391871
105behavioral defense response (GO:0002209)2.69391871
106positive regulation of membrane potential (GO:0045838)2.68659371
107membrane depolarization during action potential (GO:0086010)2.67709095
108long term synaptic depression (GO:0060292)2.66444777
109detection of chemical stimulus involved in sensory perception (GO:0050907)2.64307838
110fear response (GO:0042596)2.62209439
111neuron recognition (GO:0008038)2.61540186
112cellular response to epinephrine stimulus (GO:0071872)2.61406375
113innervation (GO:0060384)2.60819872
114cGMP-mediated signaling (GO:0019934)2.60639044
115dendritic spine morphogenesis (GO:0060997)2.60448307
116positive regulation of fatty acid metabolic process (GO:0045923)2.59036831
117regulation of ARF protein signal transduction (GO:0032012)2.58055269
118erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.57055494
119L-phenylalanine metabolic process (GO:0006558)2.57055494
120synaptic vesicle endocytosis (GO:0048488)2.56612031
121long-term synaptic potentiation (GO:0060291)2.55489580
122alanine transport (GO:0032328)2.55468585
123neuromuscular process controlling balance (GO:0050885)2.54862091
124negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.53608708
125G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.53489735
126regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.52902935
127establishment of protein localization to Golgi (GO:0072600)2.52831858
128sarcomere organization (GO:0045214)2.52230967
129hepatocyte apoptotic process (GO:0097284)2.52164529
130endothelial cell differentiation (GO:0045446)2.52056056
131cell communication involved in cardiac conduction (GO:0086065)2.51221165
132sodium ion export (GO:0071436)2.51051279
133detection of chemical stimulus (GO:0009593)2.50428980
134response to epinephrine (GO:0071871)2.49693192
135adrenergic receptor signaling pathway (GO:0071875)2.49658394
136dicarboxylic acid biosynthetic process (GO:0043650)2.49648235
137viral mRNA export from host cell nucleus (GO:0046784)2.49516425
138behavioral response to cocaine (GO:0048148)2.49114894
139membrane protein ectodomain proteolysis (GO:0006509)2.48961622
140leukotriene metabolic process (GO:0006691)2.48886362
141inner ear receptor cell development (GO:0060119)2.48271193
142dendritic spine organization (GO:0097061)2.48121009
143membrane depolarization (GO:0051899)2.47119568
144positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.46383794
145positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.46159867
146regulation of vesicle fusion (GO:0031338)2.46150154
147vesicle transport along microtubule (GO:0047496)2.46053236
148regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.45704533
149regulation of macrophage derived foam cell differentiation (GO:0010743)2.45323931
150transmission of nerve impulse (GO:0019226)2.43967286
151heterotypic cell-cell adhesion (GO:0034113)2.43648035
152regulation of dendritic spine development (GO:0060998)2.43333582
153enteric nervous system development (GO:0048484)2.42683451
154insulin secretion (GO:0030073)2.40639143
155regulation of synaptic transmission, glutamatergic (GO:0051966)2.40108446
156regulation of cardiac muscle cell contraction (GO:0086004)2.39957455
157cellular sodium ion homeostasis (GO:0006883)2.39802951
158presynaptic membrane assembly (GO:0097105)2.38203610
159cellular response to interleukin-1 (GO:0071347)2.38090706
160positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.37459651
161cardiac muscle hypertrophy (GO:0003300)2.37120697
162neurotransmitter transport (GO:0006836)2.36221546
163regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.35965010
164layer formation in cerebral cortex (GO:0021819)2.35198875
165sarcoplasmic reticulum calcium ion transport (GO:0070296)2.34895966
166retrograde transport, vesicle recycling within Golgi (GO:0000301)2.34148310
167response to growth hormone (GO:0060416)2.33470254
168regulation of female receptivity (GO:0045924)2.33154053
169retina layer formation (GO:0010842)2.32368282
170axonal fasciculation (GO:0007413)2.32339428
171hair cycle (GO:0042633)2.31922445
172molting cycle (GO:0042303)2.31922445
173positive regulation of heart rate (GO:0010460)2.31361183
174regulation of calcium ion transmembrane transporter activity (GO:1901019)2.31030062
175regulation of calcium ion transmembrane transport (GO:1903169)2.31030062
176cerebellar Purkinje cell differentiation (GO:0021702)2.30546786
177positive regulation of dendritic spine development (GO:0060999)2.30426900
178regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.30194089
179dendrite morphogenesis (GO:0048813)2.30016070
180synaptic transmission, dopaminergic (GO:0001963)2.29945236
181muscle filament sliding (GO:0030049)2.29774414
182actin-myosin filament sliding (GO:0033275)2.29774414
183* cAMP metabolic process (GO:0046058)2.29118537
184regulation of fatty acid transport (GO:2000191)2.26740436
185bone remodeling (GO:0046849)2.26666839
186striated muscle hypertrophy (GO:0014897)2.25892470

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.86736746
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.49813880
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.48164173
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.04667242
5GBX2_23144817_ChIP-Seq_PC3_Human3.23792312
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.54626758
7* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.49094581
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.41074364
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.27458673
10DROSHA_22980978_ChIP-Seq_HELA_Human2.26496996
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.25619365
12REST_21632747_ChIP-Seq_MESCs_Mouse2.25390130
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19885293
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16284834
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15869382
16* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.15093984
17* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.15093984
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.11459285
19EGR1_23403033_ChIP-Seq_LIVER_Mouse2.09761363
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.04080061
21* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.95448921
22* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.84069143
23* RXR_22158963_ChIP-Seq_LIVER_Mouse1.81610173
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.77756748
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.77158352
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.75873353
27* REST_18959480_ChIP-ChIP_MESCs_Mouse1.75433334
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.71316242
29* LXR_22158963_ChIP-Seq_LIVER_Mouse1.69312508
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.68693252
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.62596698
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.61474474
33* RNF2_27304074_Chip-Seq_ESCs_Mouse1.60356001
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.58144446
35ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.57995278
36* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.57567612
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.55347621
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55091893
39* SMAD4_21799915_ChIP-Seq_A2780_Human1.53614962
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52202473
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.50455810
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49861504
43TAF15_26573619_Chip-Seq_HEK293_Human1.42935175
44NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42805451
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41674178
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40907663
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39120053
48* CJUN_26792858_Chip-Seq_BT549_Human1.36999945
49EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35550523
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30314068
51ZNF274_21170338_ChIP-Seq_K562_Hela1.29692521
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.28592560
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26767386
54* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26590794
55* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.26489339
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.26321501
57* STAT3_23295773_ChIP-Seq_U87_Human1.22351783
58ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21788730
59* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21085313
60BCAT_22108803_ChIP-Seq_LS180_Human1.19485797
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17696941
62AR_25329375_ChIP-Seq_VCAP_Human1.17561176
63AR_19668381_ChIP-Seq_PC3_Human1.16791455
64GATA1_19941826_ChIP-Seq_K562_Human1.16470096
65AR_21572438_ChIP-Seq_LNCaP_Human1.15688245
66ARNT_22903824_ChIP-Seq_MCF-7_Human1.15130329
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15078919
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14407172
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13505296
70PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13470861
71AHR_22903824_ChIP-Seq_MCF-7_Human1.13382623
72P300_19829295_ChIP-Seq_ESCs_Human1.12068068
73WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11836323
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.11778548
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11482394
76GATA1_22025678_ChIP-Seq_K562_Human1.10411317
77FOXA2_19822575_ChIP-Seq_HepG2_Human1.09128340
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08717795
79ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08312262
80IGF1R_20145208_ChIP-Seq_DFB_Human1.07584731
81CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07558821
82SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.07532537
83TCF4_23295773_ChIP-Seq_U87_Human1.07039618
84PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06992335
85FOXO3_23340844_ChIP-Seq_DLD1_Human1.06633186
86ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05826071
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05593229
88GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05377097
89CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05298368
90HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04469886
91* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02000187
92Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01431454
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01008025
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00880295
95TP63_17297297_ChIP-ChIP_HaCaT_Human0.99461651
96TBX20_22080862_ChIP-Seq_HEART_Mouse0.99224148
97TBX20_22328084_ChIP-Seq_HEART_Mouse0.99224148
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99223633
99SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.98927456
100STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98834652
101SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98772683
102SMAD3_21741376_ChIP-Seq_HESCs_Human0.98733319
103ESR2_21235772_ChIP-Seq_MCF-7_Human0.97596471
104CBX2_27304074_Chip-Seq_ESCs_Mouse0.96935648
105RXR_22108803_ChIP-Seq_LS180_Human0.96504806
106THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96437485
107NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95462177
108NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95462177
109RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95327472
110NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94965630
111EP300_21415370_ChIP-Seq_HL-1_Mouse0.94569945
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93928829
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92585958
114* TP53_16413492_ChIP-PET_HCT116_Human0.92562199
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.92409111
116VDR_22108803_ChIP-Seq_LS180_Human0.91242839
117* KDM2B_26808549_Chip-Seq_K562_Human0.91235340
118DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90955641
119GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90282164
120VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89789991
121POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89622230
122RING1B_27294783_Chip-Seq_ESCs_Mouse0.89534244
123FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.88951805
124RUNX2_22187159_ChIP-Seq_PCA_Human0.88131865
125TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87973963
126UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87777815
127MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86718135
128TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86669710
129YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85984214
130PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.85733124
131CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85698229
132CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84270316
133GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83630406
134JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83267231
135GATA2_19941826_ChIP-Seq_K562_Human0.82769688
136LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82686795
137TRIM28_21343339_ChIP-Seq_HEK293_Human0.81425010
138* TP53_18474530_ChIP-ChIP_U2OS_Human0.80368294
139RARG_19884340_ChIP-ChIP_MEFs_Mouse0.80135282
140MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.79579805
141VDR_24787735_ChIP-Seq_THP-1_Human0.78054780
142* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.77565501
143EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.77065424
144ISL1_27105846_Chip-Seq_CPCs_Mouse0.76554456

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.47520125
2MP0003183_abnormal_peptide_metabolism4.02974891
3MP0003880_abnormal_central_pattern3.66886882
4MP0005084_abnormal_gallbladder_morpholo3.53074898
5MP0004270_analgesia3.32022941
6MP0005451_abnormal_body_composition3.27015420
7MP0003635_abnormal_synaptic_transmissio3.26685857
8MP0002837_dystrophic_cardiac_calcinosis3.11088056
9MP0009745_abnormal_behavioral_response2.74160755
10MP0002139_abnormal_hepatobiliary_system2.71254738
11MP0009764_decreased_sensitivity_to2.67386407
12MP0002063_abnormal_learning/memory/cond2.65612308
13MP0003221_abnormal_cardiomyocyte_apopto2.61834011
14MP0009780_abnormal_chondrocyte_physiolo2.61159296
15MP0003950_abnormal_plasma_membrane2.59651551
16MP0002163_abnormal_gland_morphology2.58646269
17MP0002332_abnormal_exercise_endurance2.48667447
18MP0002064_seizures2.41571871
19MP0005085_abnormal_gallbladder_physiolo2.39860930
20MP0005360_urolithiasis2.36117760
21MP0004272_abnormal_basement_membrane2.32117909
22MP0005365_abnormal_bile_salt2.32034477
23MP0000750_abnormal_muscle_regeneration2.31618542
24MP0002909_abnormal_adrenal_gland2.29622581
25MP0002822_catalepsy2.13882425
26MP0002572_abnormal_emotion/affect_behav2.13478090
27MP0005275_abnormal_skin_tensile2.05326881
28MP0009046_muscle_twitch2.05104150
29MP0008438_abnormal_cutaneous_collagen2.02272054
30MP0002272_abnormal_nervous_system1.98947164
31MP0001501_abnormal_sleep_pattern1.98712505
32MP0005379_endocrine/exocrine_gland_phen1.98584476
33MP0001968_abnormal_touch/_nociception1.95681176
34MP0003329_amyloid_beta_deposits1.89608083
35MP0001440_abnormal_grooming_behavior1.88242628
36MP0010368_abnormal_lymphatic_system1.84825862
37MP0001958_emphysema1.83374768
38MP0001486_abnormal_startle_reflex1.76125598
39MP0002734_abnormal_mechanical_nocicepti1.74439958
40MP0008875_abnormal_xenobiotic_pharmacok1.72700608
41MP0003195_calcinosis1.72301004
42MP0000371_diluted_coat_color1.68999912
43MP0003879_abnormal_hair_cell1.64909436
44MP0002735_abnormal_chemical_nociception1.63228450
45MP0002736_abnormal_nociception_after1.57583439
46MP0004145_abnormal_muscle_electrophysio1.57529488
47MP0010329_abnormal_lipoprotein_level1.56714379
48MP0003283_abnormal_digestive_organ1.56619510
49MP0003705_abnormal_hypodermis_morpholog1.54781707
50MP0000013_abnormal_adipose_tissue1.53598189
51MP0000751_myopathy1.49244795
52MP0003252_abnormal_bile_duct1.48136794
53MP0004130_abnormal_muscle_cell1.47475417
54MP0005535_abnormal_body_temperature1.47369483
55MP0000569_abnormal_digit_pigmentation1.46806764
56MP0002733_abnormal_thermal_nociception1.43772370
57MP0004087_abnormal_muscle_fiber1.43308260
58MP0004264_abnormal_extraembryonic_tissu1.40677255
59MP0002067_abnormal_sensory_capabilities1.40172714
60MP0000759_abnormal_skeletal_muscle1.39798165
61MP0008961_abnormal_basal_metabolism1.38999260
62MP0004043_abnormal_pH_regulation1.38609994
63MP0004084_abnormal_cardiac_muscle1.37458584
64MP0002106_abnormal_muscle_physiology1.35556791
65MP0010386_abnormal_urinary_bladder1.35180225
66MP0001661_extended_life_span1.33784274
67MP0001970_abnormal_pain_threshold1.32336123
68MP0004185_abnormal_adipocyte_glucose1.31206007
69MP0000733_abnormal_muscle_development1.30677173
70MP0002928_abnormal_bile_duct1.30487280
71MP0005423_abnormal_somatic_nervous1.29456943
72MP0002972_abnormal_cardiac_muscle1.27242202
73MP0005171_absent_coat_pigmentation1.23658687
74MP0001879_abnormal_lymphatic_vessel1.23472522
75MP0003011_delayed_dark_adaptation1.22772054
76MP0003633_abnormal_nervous_system1.22745653
77MP0002009_preneoplasia1.22365966
78MP0003656_abnormal_erythrocyte_physiolo1.22193087
79MP0000604_amyloidosis1.21141260
80MP0002877_abnormal_melanocyte_morpholog1.20745467
81MP0010234_abnormal_vibrissa_follicle1.20312779
82MP0004858_abnormal_nervous_system1.19193465
83MP0004233_abnormal_muscle_weight1.18551691
84MP0006138_congestive_heart_failure1.18102934
85MP0005646_abnormal_pituitary_gland1.16990919
86MP0002078_abnormal_glucose_homeostasis1.16683964
87MP0000003_abnormal_adipose_tissue1.15789858
88MP0004924_abnormal_behavior1.15708838
89MP0005386_behavior/neurological_phenoty1.15708838
90MP0002118_abnormal_lipid_homeostasis1.15165571
91MP0008872_abnormal_physiological_respon1.13764752
92MP0008569_lethality_at_weaning1.13483149
93MP0002557_abnormal_social/conspecific_i1.13467975
94MP0004215_abnormal_myocardial_fiber1.13247194
95MP0002127_abnormal_cardiovascular_syste1.12993483
96MP0003828_pulmonary_edema1.11775606
97MP0005369_muscle_phenotype1.11762333
98MP0003868_abnormal_feces_composition1.10342458
99MP0001502_abnormal_circadian_rhythm1.09336297
100MP0002108_abnormal_muscle_morphology1.09236815
101MP0004036_abnormal_muscle_relaxation1.07753810
102MP0005165_increased_susceptibility_to1.06939090
103MP0004811_abnormal_neuron_physiology1.06810491
104MP0002693_abnormal_pancreas_physiology1.05912719
105MP0000767_abnormal_smooth_muscle1.05383484
106MP0005503_abnormal_tendon_morphology1.05352002
107MP0008874_decreased_physiological_sensi1.04855022
108MP0004085_abnormal_heartbeat1.04829335
109MP0002184_abnormal_innervation1.04190728
110MP0000955_abnormal_spinal_cord1.04100708
111MP0002066_abnormal_motor_capabilities/c1.04078793
112MP0005332_abnormal_amino_acid1.02466272
113MP0000747_muscle_weakness1.02145129
114MP0001915_intracranial_hemorrhage1.01457004
115MP0005220_abnormal_exocrine_pancreas0.97842369
116MP0001765_abnormal_ion_homeostasis0.96959330
117MP0004484_altered_response_of0.96771541
118MP0003631_nervous_system_phenotype0.95745058
119MP0001666_abnormal_nutrient_absorption0.94897163
120MP0002295_abnormal_pulmonary_circulatio0.92588788
121MP0001944_abnormal_pancreas_morphology0.92396423
122MP0003646_muscle_fatigue0.92291138
123MP0009840_abnormal_foam_cell0.92290935
124MP0003091_abnormal_cell_migration0.92018779
125MP0005409_darkened_coat_color0.90769643
126MP0002876_abnormal_thyroid_physiology0.89768865
127MP0005166_decreased_susceptibility_to0.89567115
128MP0003690_abnormal_glial_cell0.88806603
129MP0005083_abnormal_biliary_tract0.88578748
130MP0004510_myositis0.88392660
131MP0002069_abnormal_eating/drinking_beha0.87488748
132MP0006276_abnormal_autonomic_nervous0.87232761
133MP0005167_abnormal_blood-brain_barrier0.87007235
134MP0003075_altered_response_to0.86253386
135MP0000778_abnormal_nervous_system0.84329293
136MP0002269_muscular_atrophy0.83893161
137MP0003806_abnormal_nucleotide_metabolis0.82200357
138MP0002882_abnormal_neuron_morphology0.82133422
139MP0005620_abnormal_muscle_contractility0.81910696
140MP0000749_muscle_degeneration0.81500735
141MP0004134_abnormal_chest_morphology0.81260784
142MP0002229_neurodegeneration0.80751458
143MP0004885_abnormal_endolymph0.79301501
144MP0003953_abnormal_hormone_level0.79238083
145MP0003172_abnormal_lysosome_physiology0.78508742
146MP0005388_respiratory_system_phenotype0.77948848
147MP0002133_abnormal_respiratory_system0.77948848
148MP0000163_abnormal_cartilage_morphology0.77903307
149MP0000230_abnormal_systemic_arterial0.77770573
150MP0005448_abnormal_energy_balance0.75092207
151MP0005187_abnormal_penis_morphology0.75051225
152MP0002090_abnormal_vision0.74960648
153MP0001544_abnormal_cardiovascular_syste0.74954221
154MP0005385_cardiovascular_system_phenoty0.74954221
155MP0003191_abnormal_cellular_cholesterol0.73813508
156MP0003045_fibrosis0.73230769
157MP0005645_abnormal_hypothalamus_physiol0.72352327
158MP0002060_abnormal_skin_morphology0.70420385
159MP0002638_abnormal_pupillary_reflex0.68917825
160MP0002998_abnormal_bone_remodeling0.68512738
161MP0005375_adipose_tissue_phenotype0.68351664
162MP0002971_abnormal_brown_adipose0.67323753
163MP0003279_aneurysm0.67258371
164MP0003959_abnormal_lean_body0.66633277
165MP0005330_cardiomyopathy0.64618972
166MP0000613_abnormal_salivary_gland0.64493684
167MP0001270_distended_abdomen0.64429510
168MP0002160_abnormal_reproductive_system0.63278356
169MP0003300_gastrointestinal_ulcer0.63161822
170MP0002089_abnormal_postnatal_growth/wei0.61145955
171MP0009384_cardiac_valve_regurgitation0.60381418

Predicted human phenotypes

RankGene SetZ-score
1Oral leukoplakia (HP:0002745)7.96396465
2Anomalous pulmonary venous return (HP:0010772)7.24823039
3Abnormality of the pulmonary veins (HP:0011718)6.49931865
4Focal motor seizures (HP:0011153)6.05269699
5Myokymia (HP:0002411)4.59321995
6Focal seizures (HP:0007359)4.34476255
7Deformed sella turcica (HP:0002681)4.22756044
8Visual hallucinations (HP:0002367)4.13762937
9Vertebral arch anomaly (HP:0008438)3.91614476
10Calf muscle hypertrophy (HP:0008981)3.90729242
11Pathologic fracture (HP:0002756)3.81470235
12Overgrowth (HP:0001548)3.77768843
13Abnormality of the odontoid process (HP:0003310)3.76850842
14Slow saccadic eye movements (HP:0000514)3.64548603
15J-shaped sella turcica (HP:0002680)3.58818503
16Muscle fibrillation (HP:0010546)3.55085843
17Tongue fasciculations (HP:0001308)3.46667795
18Atonic seizures (HP:0010819)3.39086077
19Absence seizures (HP:0002121)3.36746475
20Generalized tonic-clonic seizures (HP:0002069)3.34379282
21Hyperventilation (HP:0002883)3.25081102
22Ketoacidosis (HP:0001993)3.21311559
23Short femoral neck (HP:0100864)3.20788737
24Broad ribs (HP:0000885)3.20276263
25Dialeptic seizures (HP:0011146)3.16999992
26Amelogenesis imperfecta (HP:0000705)3.14345574
27Abnormality of the sella turcica (HP:0002679)3.12308982
28Abnormality of the calf musculature (HP:0001430)3.10871038
29Hyperinsulinemic hypoglycemia (HP:0000825)3.09055671
30Abnormality of aromatic amino acid family metabolism (HP:0004338)3.05780748
31Epileptic encephalopathy (HP:0200134)3.05156921
32Ketosis (HP:0001946)3.01910970
33Flat acetabular roof (HP:0003180)3.01846832
34Testicular atrophy (HP:0000029)2.99598375
35Action tremor (HP:0002345)2.97406631
36Rough bone trabeculation (HP:0100670)2.96163662
37Diastasis recti (HP:0001540)2.95828062
38Vertebral fusion (HP:0002948)2.92323377
39Febrile seizures (HP:0002373)2.91139966
40Progressive cerebellar ataxia (HP:0002073)2.87648191
41Global brain atrophy (HP:0002283)2.84806023
42Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.82447012
43Frequent falls (HP:0002359)2.80220898
44Neoplasm of the heart (HP:0100544)2.78275724
45Myelomeningocele (HP:0002475)2.76198403
46Cerebral inclusion bodies (HP:0100314)2.75649800
47Mitral stenosis (HP:0001718)2.75332538
48Impaired social interactions (HP:0000735)2.72833148
49Abnormal social behavior (HP:0012433)2.72833148
50Dysdiadochokinesis (HP:0002075)2.71476066
51Distal lower limb muscle weakness (HP:0009053)2.70587918
52Thoracolumbar scoliosis (HP:0002944)2.70356023
53Status epilepticus (HP:0002133)2.70046608
54EMG: myopathic abnormalities (HP:0003458)2.69310990
55Dysmetria (HP:0001310)2.68460899
56Abnormality of glycosphingolipid metabolism (HP:0004343)2.66838655
57Abnormality of glycolipid metabolism (HP:0010969)2.66838655
58Abnormality of liposaccharide metabolism (HP:0010968)2.66838655
59Deep venous thrombosis (HP:0002625)2.64835804
60Poor eye contact (HP:0000817)2.64425855
61Aortic regurgitation (HP:0001659)2.63659113
62Exercise-induced myalgia (HP:0003738)2.63157320
63Increased connective tissue (HP:0009025)2.61854759
64Difficulty climbing stairs (HP:0003551)2.61534310
65Supranuclear gaze palsy (HP:0000605)2.61199285
66Epileptiform EEG discharges (HP:0011182)2.60005840
67Anxiety (HP:0000739)2.56302627
68Gaze-evoked nystagmus (HP:0000640)2.55950484
69Hyperglycinemia (HP:0002154)2.53568386
70Xanthomatosis (HP:0000991)2.51880246
71Hypoglycemic coma (HP:0001325)2.51497807
72Postural instability (HP:0002172)2.51451225
73Neurofibrillary tangles (HP:0002185)2.51150635
74Difficulty running (HP:0009046)2.49890710
75Intrahepatic cholestasis (HP:0001406)2.49315869
76Type 1 muscle fiber predominance (HP:0003803)2.49107519
77Depression (HP:0000716)2.48966828
78Aplasia/hypoplasia of the femur (HP:0005613)2.48525102
79Prolonged partial thromboplastin time (HP:0003645)2.48329855
80Sudden death (HP:0001699)2.47554344
81Impaired vibration sensation in the lower limbs (HP:0002166)2.45758773
82Abnormality of the lumbar spine (HP:0100712)2.45144216
83Dysmetric saccades (HP:0000641)2.45107866
84Muscle fiber splitting (HP:0003555)2.43212126
85Abnormality of the intervertebral disk (HP:0005108)2.42114228
86Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.41818997
87Short 4th metacarpal (HP:0010044)2.41818997
88Abnormality of the lower motor neuron (HP:0002366)2.40192000
89EEG with generalized epileptiform discharges (HP:0011198)2.37863208
90Decreased circulating renin level (HP:0003351)2.36617689
91Broad-based gait (HP:0002136)2.36127555
92Truncal ataxia (HP:0002078)2.31895102
93Excessive salivation (HP:0003781)2.31237607
94Drooling (HP:0002307)2.31237607
95Bundle branch block (HP:0011710)2.29564634
96Hyperlipoproteinemia (HP:0010980)2.29242991
97Hypoglycemic seizures (HP:0002173)2.28433904
98Hyperglycemia (HP:0003074)2.28270839
99Skin nodule (HP:0200036)2.22015306
100Hypsarrhythmia (HP:0002521)2.22012492
101Scanning speech (HP:0002168)2.21827213
102Syncope (HP:0001279)2.21208736
103Gout (HP:0001997)2.19719341
104Premature graying of hair (HP:0002216)2.19244009
105Amblyopia (HP:0000646)2.18773209
106Impaired vibratory sensation (HP:0002495)2.17242090
107Complement deficiency (HP:0004431)2.17107355
108Urinary bladder sphincter dysfunction (HP:0002839)2.16109822
109Impaired smooth pursuit (HP:0007772)2.15944567
110Osteomalacia (HP:0002749)2.15892636
111Prominent occiput (HP:0000269)2.15005939
112Asymmetric septal hypertrophy (HP:0001670)2.13183755
113Ventricular fibrillation (HP:0001663)2.12649140
114Genetic anticipation (HP:0003743)2.10721648
115Carpal bone hypoplasia (HP:0001498)2.10663272
116Abnormal trabecular bone morphology (HP:0100671)2.10437520
117Flared iliac wings (HP:0002869)2.10387224
118Death in childhood (HP:0003819)2.09521674
119Conjugated hyperbilirubinemia (HP:0002908)2.08999136
120Insulin-resistant diabetes mellitus (HP:0000831)2.08553470
121Hyperkalemia (HP:0002153)2.06677378
122Intention tremor (HP:0002080)2.06652323
123Muscle fiber inclusion bodies (HP:0100299)2.06172687
124Bradykinesia (HP:0002067)2.05500871
125Abnormality of monocarboxylic acid metabolism (HP:0010996)2.03581925
126Round ear (HP:0100830)2.03345131
127Ovoid vertebral bodies (HP:0003300)2.02176883
128Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.01332944
129Hyperglycinuria (HP:0003108)1.98634659
130Achilles tendon contracture (HP:0001771)1.96890516
131Hypoalphalipoproteinemia (HP:0003233)1.94407720
132Abnormality of the 4th metacarpal (HP:0010012)1.93396291
133Lipoatrophy (HP:0100578)1.93352649
134Resting tremor (HP:0002322)1.92259130
135Abnormality of the common coagulation pathway (HP:0010990)1.92180736
136Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.91631531
137Torticollis (HP:0000473)1.91522213
138Scapular winging (HP:0003691)1.90295486
139Epidermoid cyst (HP:0200040)1.87897820
140Abnormality of glycine metabolism (HP:0010895)1.86938211
141Abnormality of serine family amino acid metabolism (HP:0010894)1.86938211
142Generalized myoclonic seizures (HP:0002123)1.86427377
143Sparse lateral eyebrow (HP:0005338)1.86388590
144Skin pits (HP:0100276)1.86359252
145Retinal atrophy (HP:0001105)1.86259984
146Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.85930138
147Abnormality of the Achilles tendon (HP:0005109)1.85478032
148Pheochromocytoma (HP:0002666)1.85198517
149Urinary glycosaminoglycan excretion (HP:0003541)1.84876419
150Mucopolysacchariduria (HP:0008155)1.84876419
151Increased circulating renin level (HP:0000848)1.84262009
152Abnormality of the intrinsic pathway (HP:0010989)1.83164544
153Long toe (HP:0010511)1.81370123
154Thin skin (HP:0000963)1.81160938
155Nemaline bodies (HP:0003798)1.80949994
156Hemiplegia (HP:0002301)1.80828566
157Hyporeflexia of lower limbs (HP:0002600)1.80629793
158Hyperammonemia (HP:0001987)1.80591566
159Areflexia of lower limbs (HP:0002522)1.80261158
160Insidious onset (HP:0003587)1.80025773
161Termporal pattern (HP:0011008)1.80025773
162Morphological abnormality of the pyramidal tract (HP:0002062)1.79925959
163Symptomatic seizures (HP:0011145)1.79237662
164Confusion (HP:0001289)1.79226802
165Focal dystonia (HP:0004373)1.79162465
166Agitation (HP:0000713)1.78665913
167Neuronal loss in central nervous system (HP:0002529)1.77979925
168Rapidly progressive (HP:0003678)1.77659330
169Atrial fibrillation (HP:0005110)1.76745310
170Blue irides (HP:0000635)1.76585205
171Increased variability in muscle fiber diameter (HP:0003557)1.76317532
172Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.76080112
173Ventricular arrhythmia (HP:0004308)1.75253324
174Abnormality of ocular smooth pursuit (HP:0000617)1.74222540
175Muscle hypertrophy of the lower extremities (HP:0008968)1.73581284
176Distal lower limb amyotrophy (HP:0008944)1.71591978
177Striae distensae (HP:0001065)1.68803257
178Hemivertebrae (HP:0002937)1.67659549
179Dysostosis multiplex (HP:0000943)1.66833023
180Short nail (HP:0001799)1.65239662
181Meningocele (HP:0002435)1.65007390
182Limb-girdle muscle atrophy (HP:0003797)1.64158861
183Myocardial infarction (HP:0001658)1.62624077
184Myoglobinuria (HP:0002913)1.61792232
185Muscular dystrophy (HP:0003560)1.59386224
186Thoracic kyphosis (HP:0002942)1.59247979
187Preauricular pit (HP:0004467)1.58839577
188Periauricular skin pits (HP:0100277)1.58839577
189Thickened calvaria (HP:0002684)1.57905397
190Aortic aneurysm (HP:0004942)1.57875052

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK9.50259895
2EPHA45.03318646
3NTRK34.44665640
4MAP3K93.64138391
5RIPK43.12802722
6TLK12.99005510
7INSRR2.56334548
8MAP3K42.42992116
9KSR22.23065280
10DAPK22.20732145
11NTRK12.04996171
12IRAK32.00445799
13MAP2K41.99522463
14MAP3K131.99039933
15ZAK1.90717672
16ARAF1.85364937
17PRKD31.81863522
18MINK11.68741974
19TTN1.60094948
20PAK61.56009128
21MAP2K71.56002622
22TGFBR21.55359292
23MAP3K21.54661719
24CAMKK11.52291237
25SIK21.33313331
26KSR11.29879371
27CDK51.27365228
28DAPK11.25172414
29MARK11.19811465
30PINK11.19254130
31FRK1.19203899
32STK41.18891346
33CAMKK21.17877348
34GRK51.16673596
35STK381.15410134
36NEK91.15376432
37BMPR21.14497157
38GRK71.11989648
39PRKCG1.10959952
40CAMK2B1.07383380
41SGK31.06900253
42EPHA31.06007670
43TAOK31.05727247
44CASK1.04503344
45CAMK2A1.04204068
46NTRK21.02372801
47FES1.02264439
48PHKG21.02176678
49PHKG11.02176678
50PTK2B1.02057946
51AKT31.01358192
52PNCK0.99790365
53KDR0.98815407
54MAP3K10.98634134
55PLK20.98102534
56CAMK10.93860750
57RAF10.93478826
58PDPK10.92951002
59MARK20.92645372
60MAP3K70.91040789
61CAMK1G0.90838345
62RIPK10.90347515
63PDK10.88602181
64RET0.87616910
65SYK0.87256593
66MAP3K120.84988028
67EPHA20.84561535
68STK240.84130523
69SGK20.83301967
70SGK4940.81482150
71SGK2230.81482150
72NME10.81325721
73PRKCH0.80017046
74DMPK0.79359324
75SGK10.79152297
76CAMK2D0.78283099
77PAK30.75874903
78BCKDK0.73533965
79FER0.72132791
80CAMK1D0.71624435
81STK110.71347831
82GRK60.71307378
83TRIB30.71289077
84CAMK2G0.69183475
85TNIK0.68723608
86MAP2K30.66107647
87RPS6KA50.65194553
88PRPF4B0.64480221
89PDGFRB0.64072486
90ABL20.63689314
91PIM10.63513192
92STK30.63253656
93BRAF0.63137355
94PRKCE0.62003644
95TYRO30.61304902
96LMTK20.60403524
97MAP2K10.59453155
98HIPK20.59433403
99PDK30.58849903
100PDK40.58849903
101NEK60.58181245
102PKN20.58020335
103PKN10.56995294
104CDC42BPA0.56371329
105FGR0.55604504
106CSNK1G20.54779198
107WNK40.54300244
108DAPK30.53974641
109MAP4K10.52166875
110RPS6KA30.51764918
111SIK10.51244167
112MAPK130.50895057
113TAOK10.50180696
114JAK20.49761097
115PIK3CG0.49738502
116PRKAA20.49418533
117CAMK40.47310216
118STK38L0.46026414
119PTK20.45839571
120PDGFRA0.44338585
121PRKD20.44219092
122EEF2K0.44082939
123MAPK100.43979249
124PRKAA10.43895931
125MAP3K50.43564039
126WNK10.42875529
127PRKCZ0.42627070
128MAPK120.42619149
129SCYL20.41575011
130STK390.40691208
131MAP3K60.39856128
132OBSCN0.39592268
133MOS0.39496817
134DYRK1A0.39344320
135HCK0.39014296
136FGFR30.38840637
137PRKACA0.38557118
138PDK20.36563028
139CSK0.35704312
140MAP3K30.35099063
141IRAK40.34854547
142VRK10.34696840
143LYN0.34327784
144RPS6KA20.34242198
145MAPK40.33818457
146IKBKE0.33269647
147TRPM70.33003922
148RPS6KA60.32718915
149RPS6KC10.29057876
150RPS6KL10.29057876
151MUSK0.27875797
152ICK0.27657118
153AKT20.27626317
154FYN0.27089659
155ADRBK10.26873848
156ERBB20.26251840
157MST1R0.24181546
158IRAK10.23691479

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053224.52566652
2Alcoholism_Homo sapiens_hsa050343.12638667
3Nicotine addiction_Homo sapiens_hsa050332.67995669
4Nitrogen metabolism_Homo sapiens_hsa009102.54155765
5Long-term potentiation_Homo sapiens_hsa047202.34188378
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.21089077
7* Insulin secretion_Homo sapiens_hsa049112.16168374
8Amphetamine addiction_Homo sapiens_hsa050312.15427256
9* Circadian entrainment_Homo sapiens_hsa047132.15005466
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.02429311
11* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.02411611
12* Glutamatergic synapse_Homo sapiens_hsa047241.99422024
13* GABAergic synapse_Homo sapiens_hsa047271.88360484
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.87541442
15Synaptic vesicle cycle_Homo sapiens_hsa047211.81628404
16* Salivary secretion_Homo sapiens_hsa049701.76619242
17Arginine biosynthesis_Homo sapiens_hsa002201.71816199
18* Morphine addiction_Homo sapiens_hsa050321.71724236
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.67453386
20* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66649674
21* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.64879260
22Dopaminergic synapse_Homo sapiens_hsa047281.59221058
23Olfactory transduction_Homo sapiens_hsa047401.57697964
24Type II diabetes mellitus_Homo sapiens_hsa049301.52230045
25Renin secretion_Homo sapiens_hsa049241.51851068
26Taste transduction_Homo sapiens_hsa047421.51512938
27Staphylococcus aureus infection_Homo sapiens_hsa051501.38188734
28* Gastric acid secretion_Homo sapiens_hsa049711.37104525
29* Calcium signaling pathway_Homo sapiens_hsa040201.36868785
30* Cholinergic synapse_Homo sapiens_hsa047251.35658741
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.34705081
32Long-term depression_Homo sapiens_hsa047301.33964188
33Osteoclast differentiation_Homo sapiens_hsa043801.30699792
34Viral carcinogenesis_Homo sapiens_hsa052031.29696471
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.29181377
36* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.28887966
37* Oxytocin signaling pathway_Homo sapiens_hsa049211.27731105
38* Platelet activation_Homo sapiens_hsa046111.26095484
39Cocaine addiction_Homo sapiens_hsa050301.25195778
40* Bile secretion_Homo sapiens_hsa049761.20954569
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20932229
42Butanoate metabolism_Homo sapiens_hsa006501.20927613
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19732513
44ECM-receptor interaction_Homo sapiens_hsa045121.17155849
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16755295
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13443631
47* Ovarian steroidogenesis_Homo sapiens_hsa049131.12531206
48Serotonergic synapse_Homo sapiens_hsa047261.09899366
49* cAMP signaling pathway_Homo sapiens_hsa040241.09671916
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08465927
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06325875
52* GnRH signaling pathway_Homo sapiens_hsa049121.04443462
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02555401
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01421641
55Prolactin signaling pathway_Homo sapiens_hsa049171.00779328
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99543909
57Leishmaniasis_Homo sapiens_hsa051400.99213466
58Glucagon signaling pathway_Homo sapiens_hsa049220.99086292
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98728669
60* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98711301
61Tryptophan metabolism_Homo sapiens_hsa003800.96760583
62Focal adhesion_Homo sapiens_hsa045100.95731492
63TNF signaling pathway_Homo sapiens_hsa046680.94418577
64* Pancreatic secretion_Homo sapiens_hsa049720.94399935
65FoxO signaling pathway_Homo sapiens_hsa040680.94392293
66Fatty acid degradation_Homo sapiens_hsa000710.93597305
67* Vascular smooth muscle contraction_Homo sapiens_hsa042700.92458425
68Tuberculosis_Homo sapiens_hsa051520.91316121
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90064354
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90035596
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.88638527
72Linoleic acid metabolism_Homo sapiens_hsa005910.87269227
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86792700
74Pancreatic cancer_Homo sapiens_hsa052120.86336457
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85939035
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84726334
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.84515223
78* Estrogen signaling pathway_Homo sapiens_hsa049150.84315297
79Propanoate metabolism_Homo sapiens_hsa006400.83202966
80* Gap junction_Homo sapiens_hsa045400.78730222
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78587279
82PPAR signaling pathway_Homo sapiens_hsa033200.78207163
83Cardiac muscle contraction_Homo sapiens_hsa042600.77071540
84Complement and coagulation cascades_Homo sapiens_hsa046100.75420509
85Bladder cancer_Homo sapiens_hsa052190.75116132
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74865705
87MAPK signaling pathway_Homo sapiens_hsa040100.74817072
88Glioma_Homo sapiens_hsa052140.74057896
89* Thyroid hormone synthesis_Homo sapiens_hsa049180.72980878
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72894246
91* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72495424
92Collecting duct acid secretion_Homo sapiens_hsa049660.70517506
93Sulfur metabolism_Homo sapiens_hsa009200.69908165
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69765714
95* Dilated cardiomyopathy_Homo sapiens_hsa054140.69148172
96Fatty acid metabolism_Homo sapiens_hsa012120.67892303
97* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67175618
98Dorso-ventral axis formation_Homo sapiens_hsa043200.66556687
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64154795
100ABC transporters_Homo sapiens_hsa020100.63985216
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63955572
102Non-small cell lung cancer_Homo sapiens_hsa052230.63452116
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63100603
104Starch and sucrose metabolism_Homo sapiens_hsa005000.60843272
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.59367235
106* Melanogenesis_Homo sapiens_hsa049160.59280316
107Melanoma_Homo sapiens_hsa052180.59169535
108Prion diseases_Homo sapiens_hsa050200.59125153
109* Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58743531
110Choline metabolism in cancer_Homo sapiens_hsa052310.58283924
111Renin-angiotensin system_Homo sapiens_hsa046140.57772963
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57407606
113Insulin resistance_Homo sapiens_hsa049310.56785474
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56671253
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56506372
116Glycerolipid metabolism_Homo sapiens_hsa005610.56449370
117* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56139887
118Circadian rhythm_Homo sapiens_hsa047100.55166055
119Insulin signaling pathway_Homo sapiens_hsa049100.52707407
120Fat digestion and absorption_Homo sapiens_hsa049750.52705999
121* Phospholipase D signaling pathway_Homo sapiens_hsa040720.51187226
122Fatty acid biosynthesis_Homo sapiens_hsa000610.51157458
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.50339121
124Caffeine metabolism_Homo sapiens_hsa002320.50292984
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50089129
126Ras signaling pathway_Homo sapiens_hsa040140.49722468
127ErbB signaling pathway_Homo sapiens_hsa040120.49591850
128Toxoplasmosis_Homo sapiens_hsa051450.47736002
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47730679
130Inositol phosphate metabolism_Homo sapiens_hsa005620.46354735
131Renal cell carcinoma_Homo sapiens_hsa052110.46287087
132Small cell lung cancer_Homo sapiens_hsa052220.46209126
133Hepatitis C_Homo sapiens_hsa051600.45070009
134AMPK signaling pathway_Homo sapiens_hsa041520.44703871
135Amoebiasis_Homo sapiens_hsa051460.44060941
136* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44057286
137VEGF signaling pathway_Homo sapiens_hsa043700.42500903
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.42363810
139Pyruvate metabolism_Homo sapiens_hsa006200.41613842
140Peroxisome_Homo sapiens_hsa041460.41306984
141Phenylalanine metabolism_Homo sapiens_hsa003600.40819042
142Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38213142
143mTOR signaling pathway_Homo sapiens_hsa041500.37977188
144Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37679535
145* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37423197
146Alzheimers disease_Homo sapiens_hsa050100.35864544
147* Vibrio cholerae infection_Homo sapiens_hsa051100.35299421
148Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35126510

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