ADCYAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.08886184
2negative regulation of gluconeogenesis (GO:0045721)5.59460693
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.47418026
4neuron cell-cell adhesion (GO:0007158)5.44129791
5regulation of glucokinase activity (GO:0033131)5.43090552
6regulation of hexokinase activity (GO:1903299)5.43090552
7positive regulation of respiratory burst (GO:0060267)5.36255349
8glutamate secretion (GO:0014047)5.26650308
9positive regulation of synaptic transmission, GABAergic (GO:0032230)5.24137262
10positive regulation of glycolytic process (GO:0045821)5.18169329
11endocrine pancreas development (GO:0031018)5.08907039
12synaptic vesicle maturation (GO:0016188)5.07318303
13regulation of type B pancreatic cell apoptotic process (GO:2000674)5.06883270
14synaptic vesicle exocytosis (GO:0016079)4.91745579
15negative regulation of glycogen metabolic process (GO:0070874)4.85040914
16protein localization to synapse (GO:0035418)4.82919608
17vocalization behavior (GO:0071625)4.80051993
18regulation of synaptic vesicle exocytosis (GO:2000300)4.74495325
19negative regulation of protein oligomerization (GO:0032460)4.74401160
20layer formation in cerebral cortex (GO:0021819)4.68151721
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.66735872
22neuron recognition (GO:0008038)4.62251663
23negative regulation of hormone biosynthetic process (GO:0032353)4.50751151
24synaptic vesicle docking involved in exocytosis (GO:0016081)4.45891842
25positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.34341509
26regulation of glutamate receptor signaling pathway (GO:1900449)4.32621036
27nitric oxide mediated signal transduction (GO:0007263)4.30207193
28chemosensory behavior (GO:0007635)4.25513716
29neuronal action potential propagation (GO:0019227)4.24910887
30insulin secretion (GO:0030073)4.22469573
31positive regulation of action potential (GO:0045760)4.22439639
32positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.18518337
33proline transport (GO:0015824)4.18223014
34locomotory exploration behavior (GO:0035641)4.16868083
35fatty acid homeostasis (GO:0055089)4.11353110
36cell migration in hindbrain (GO:0021535)4.09657478
37regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.09290376
38regulation of synaptic vesicle transport (GO:1902803)4.08872198
39lactate metabolic process (GO:0006089)4.05228145
40neurotransmitter secretion (GO:0007269)4.04895090
41positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.94896394
42pyrimidine nucleobase catabolic process (GO:0006208)3.94580474
43regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.89724476
44axonal fasciculation (GO:0007413)3.86472275
45regulation of feeding behavior (GO:0060259)3.84573008
46negative regulation of synaptic transmission, GABAergic (GO:0032229)3.83346817
47activation of protein kinase A activity (GO:0034199)3.82433082
48negative regulation of hormone metabolic process (GO:0032351)3.78913718
49nucleoside diphosphate catabolic process (GO:0009134)3.78752188
50ionotropic glutamate receptor signaling pathway (GO:0035235)3.77655255
51exploration behavior (GO:0035640)3.76950988
52type B pancreatic cell development (GO:0003323)3.74767172
53presynaptic membrane assembly (GO:0097105)3.73222250
54postsynaptic membrane organization (GO:0001941)3.71868695
55negative regulation of microtubule polymerization (GO:0031115)3.71590913
56regulation of glucocorticoid secretion (GO:2000849)3.70994465
57neuromuscular process controlling posture (GO:0050884)3.69744787
58positive regulation of glycogen biosynthetic process (GO:0045725)3.69661070
59long-term memory (GO:0007616)3.69281215
60dendritic spine morphogenesis (GO:0060997)3.64836465
61detection of calcium ion (GO:0005513)3.64727110
62regulation of neuronal synaptic plasticity (GO:0048168)3.64169265
63gamma-aminobutyric acid signaling pathway (GO:0007214)3.61973032
64glutamate receptor signaling pathway (GO:0007215)3.60220897
65regulation of long-term neuronal synaptic plasticity (GO:0048169)3.57323063
66negative regulation of catecholamine secretion (GO:0033604)3.52009298
67regulation of synaptic transmission, GABAergic (GO:0032228)3.46828386
68positive regulation of insulin secretion (GO:0032024)3.45980444
69cellular ketone body metabolic process (GO:0046950)3.43804445
70neurotransmitter-gated ion channel clustering (GO:0072578)3.43183624
71neurotransmitter transport (GO:0006836)3.42852378
72* positive regulation of peptide hormone secretion (GO:0090277)3.42405257
73nucleobase catabolic process (GO:0046113)3.42276394
74axon extension (GO:0048675)3.41982977
75regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.39696753
76presynaptic membrane organization (GO:0097090)3.39552721
77neuron-neuron synaptic transmission (GO:0007270)3.37744042
78tachykinin receptor signaling pathway (GO:0007217)3.37687379
79dendrite morphogenesis (GO:0048813)3.36427097
80positive regulation of synapse assembly (GO:0051965)3.36400132
81neuronal ion channel clustering (GO:0045161)3.35458288
82positive regulation of glycogen metabolic process (GO:0070875)3.34802082
83synaptic transmission, glutamatergic (GO:0035249)3.34061986
84transmission of nerve impulse (GO:0019226)3.33963914
85negative regulation of cytosolic calcium ion concentration (GO:0051481)3.33250791
86regulation of synapse structural plasticity (GO:0051823)3.32580045
87positive regulation of neurotransmitter transport (GO:0051590)3.31138518
88regulation of protein kinase A signaling (GO:0010738)3.31051585
89gamma-aminobutyric acid transport (GO:0015812)3.31046651
90* positive regulation of peptide secretion (GO:0002793)3.30608612
91positive regulation of insulin receptor signaling pathway (GO:0046628)3.28190287
92cerebellar Purkinje cell differentiation (GO:0021702)3.28169595
93regulation of vesicle fusion (GO:0031338)3.27364262
94synaptic vesicle endocytosis (GO:0048488)3.27048101
95behavioral response to nicotine (GO:0035095)3.25359642
96response to histamine (GO:0034776)3.22763296
97innervation (GO:0060384)3.22446798
98mating behavior (GO:0007617)3.21376420
99regulation of cAMP-dependent protein kinase activity (GO:2000479)3.20231572
100regulation of insulin secretion (GO:0050796)3.18973469
101positive regulation of potassium ion transmembrane transport (GO:1901381)3.17586943
102positive regulation of protein autophosphorylation (GO:0031954)3.17586423
103regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.17269713
104regulation of neurotransmitter levels (GO:0001505)3.16855883
105detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.16138829
106detection of temperature stimulus involved in sensory perception (GO:0050961)3.16138829
107synapse assembly (GO:0007416)3.14983416
108regulation of action potential (GO:0098900)3.13631044
109inositol phosphate catabolic process (GO:0071545)3.13507118
110cerebellar granule cell differentiation (GO:0021707)3.11747588
111cellular potassium ion homeostasis (GO:0030007)3.09401330
112negative regulation of dendrite morphogenesis (GO:0050774)3.07647153
113regulation of excitatory postsynaptic membrane potential (GO:0060079)3.07574057
114glandular epithelial cell differentiation (GO:0002067)3.05090453
115peptide hormone secretion (GO:0030072)3.04045813
116ketone body metabolic process (GO:1902224)3.03949501
117regulation of respiratory system process (GO:0044065)3.03167684
118* regulation of postsynaptic membrane potential (GO:0060078)3.03081868
119regulation of neurotransmitter secretion (GO:0046928)3.02716122
120righting reflex (GO:0060013)3.02200006
121response to auditory stimulus (GO:0010996)3.01563313
122regulation of corticosteroid hormone secretion (GO:2000846)3.01437455
123calcium ion-dependent exocytosis (GO:0017156)3.00231254
124neuron projection extension (GO:1990138)2.99631421
125auditory behavior (GO:0031223)2.99147693
126membrane depolarization during action potential (GO:0086010)2.98484571
127neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.97929531
128dendrite development (GO:0016358)2.96216593
129regulation of synapse assembly (GO:0051963)2.95782283
130opioid receptor signaling pathway (GO:0038003)2.95046079
131neuromuscular process controlling balance (GO:0050885)2.94332315
132axon cargo transport (GO:0008088)2.94071550
133positive regulation of membrane potential (GO:0045838)2.93697166
134detection of temperature stimulus (GO:0016048)2.93300710
135regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.92799992
136negative regulation of heart rate (GO:0010459)2.92313995
137organelle transport along microtubule (GO:0072384)2.92022070
138peptide secretion (GO:0002790)2.91513154
139regulation of calcium ion-dependent exocytosis (GO:0017158)2.91148377
140learning (GO:0007612)2.90963179
141positive regulation of synapse maturation (GO:0090129)2.89455401
142startle response (GO:0001964)2.88791610
143glycerophospholipid catabolic process (GO:0046475)2.87073140
144* regulation of peptide hormone secretion (GO:0090276)2.85648286
145negative regulation of neurological system process (GO:0031645)2.79761883
146* regulation of peptide secretion (GO:0002791)2.79213561
147brain morphogenesis (GO:0048854)2.77289747
148regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.76708814
149regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.76708814
150dentate gyrus development (GO:0021542)2.76543361
151cellular response to leptin stimulus (GO:0044320)2.76529877
152positive regulation of nitric-oxide synthase activity (GO:0051000)2.76120214
153calcium ion import (GO:0070509)2.73537908
154phosphorylated carbohydrate dephosphorylation (GO:0046838)2.72347360
155inositol phosphate dephosphorylation (GO:0046855)2.72347360
156substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.71722272
157substrate-independent telencephalic tangential migration (GO:0021826)2.71722272
158kidney morphogenesis (GO:0060993)2.70007711
159adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.69423927
160neurofilament cytoskeleton organization (GO:0060052)2.69340698
161dendritic spine organization (GO:0097061)2.68551028
162protein targeting to Golgi (GO:0000042)2.67981436
163regulation of respiratory burst (GO:0060263)2.66790985
164epithelial cell fate commitment (GO:0072148)2.65160947
165* positive regulation of hormone secretion (GO:0046887)2.64824195
166regulation of energy homeostasis (GO:2000505)2.62528969
167establishment of protein localization to Golgi (GO:0072600)2.62101679
168membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.58849004
169response to leptin (GO:0044321)2.57751851
170protein localization to cilium (GO:0061512)2.57412904
171protein localization to Golgi apparatus (GO:0034067)2.57219285
172retinal ganglion cell axon guidance (GO:0031290)2.56375794
173prepulse inhibition (GO:0060134)2.56315448
174negative regulation of dendrite development (GO:2000171)2.55209148
175glandular epithelial cell development (GO:0002068)2.54997142
176* negative regulation of acute inflammatory response (GO:0002674)2.54612407
177regulation of cilium movement (GO:0003352)2.54575245
178nonmotile primary cilium assembly (GO:0035058)2.54032705
179* regulation of hormone secretion (GO:0046883)2.52674445
180neuron maturation (GO:0042551)2.51768144

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.40430147
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.37726901
3GBX2_23144817_ChIP-Seq_PC3_Human3.63988413
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19423370
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08237364
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96947352
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.93805756
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.81179367
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.68439317
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.66183890
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.65780358
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.63904028
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61639995
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61639995
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57854501
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55229354
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.52391710
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.49426686
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49204874
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.47973363
21TAF15_26573619_Chip-Seq_HEK293_Human2.42960220
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.36141301
23* REST_18959480_ChIP-ChIP_MESCs_Mouse2.31567115
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22352018
25* EZH2_27294783_Chip-Seq_ESCs_Mouse2.21493874
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.20683126
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.06892753
28CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02299126
29DROSHA_22980978_ChIP-Seq_HELA_Human2.00877478
30ZNF274_21170338_ChIP-Seq_K562_Hela1.99170773
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.94577438
32* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.92761447
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.81501264
34* AR_21572438_ChIP-Seq_LNCaP_Human1.79761251
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.78927508
36SMAD4_21799915_ChIP-Seq_A2780_Human1.69587872
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69001026
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64038559
39* P300_19829295_ChIP-Seq_ESCs_Human1.62284439
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58037342
41RNF2_27304074_Chip-Seq_NSC_Mouse1.50912073
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.50641022
43* CBX2_27304074_Chip-Seq_ESCs_Mouse1.47612369
44* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44361584
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40576906
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39967420
47NANOG_18555785_Chip-Seq_ESCs_Mouse1.38832047
48* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38151096
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36611625
50* SOX2_21211035_ChIP-Seq_LN229_Gbm1.35554945
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35413493
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.34989931
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34976414
54* RING1B_27294783_Chip-Seq_ESCs_Mouse1.31973310
55IGF1R_20145208_ChIP-Seq_DFB_Human1.29688332
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.28337016
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.28050007
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.26851678
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26835167
60RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26465176
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26004137
62AR_25329375_ChIP-Seq_VCAP_Human1.25538157
63EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25056932
64P53_22387025_ChIP-Seq_ESCs_Mouse1.22468548
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21993438
66CBP_20019798_ChIP-Seq_JUKART_Human1.21993438
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16917151
68BCAT_22108803_ChIP-Seq_LS180_Human1.16809819
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16759613
70* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15947803
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15083806
72ER_23166858_ChIP-Seq_MCF-7_Human1.15051317
73EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13812836
74TP53_22573176_ChIP-Seq_HFKS_Human1.13552758
75DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12591174
76ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12505789
77EWS_26573619_Chip-Seq_HEK293_Human1.12294597
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12166320
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11143138
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10502032
81STAT3_23295773_ChIP-Seq_U87_Human1.10229717
82* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09890018
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.08988367
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.08900051
85FUS_26573619_Chip-Seq_HEK293_Human1.08655580
86AHR_22903824_ChIP-Seq_MCF-7_Human1.08610198
87AR_19668381_ChIP-Seq_PC3_Human1.08479588
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07128435
89RUNX2_22187159_ChIP-Seq_PCA_Human1.06742047
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06695506
91RING1B_27294783_Chip-Seq_NPCs_Mouse1.06290038
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06255341
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05569900
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05519537
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.04903974
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04549336
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02571523
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.02053501
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02014128
100RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01852444
101GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01311933
102MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01266325
103TCF4_23295773_ChIP-Seq_U87_Human1.00893849
104EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00881675
105SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00642073
106EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00441882
107FLI1_21867929_ChIP-Seq_TH2_Mouse1.00101891
108HTT_18923047_ChIP-ChIP_STHdh_Human0.99937745
109ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98716933
110EZH2_27294783_Chip-Seq_NPCs_Mouse0.98689071
111SMAD3_21741376_ChIP-Seq_ESCs_Human0.98613447
112ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97987328
113* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97504215
114JUN_21703547_ChIP-Seq_K562_Human0.94194613
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92359863
116TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92359863
117WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90459733
118VDR_22108803_ChIP-Seq_LS180_Human0.90428024
119KDM2B_26808549_Chip-Seq_REH_Human0.87468566
120* PRDM14_20953172_ChIP-Seq_ESCs_Human0.87369130
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86999682
122TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86155887
123TP53_18474530_ChIP-ChIP_U2OS_Human0.85563359
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83668204
125CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.83582848
126SMAD4_21741376_ChIP-Seq_HESCs_Human0.83523511
127MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83506474
128TET1_21490601_ChIP-Seq_MESCs_Mouse0.82253529
129TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82218667
130* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.82052186

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.33823221
2MP0004859_abnormal_synaptic_plasticity4.75280004
3MP0001968_abnormal_touch/_nociception4.12145018
4MP0004270_analgesia3.81616358
5MP0006276_abnormal_autonomic_nervous3.79026241
6MP0002735_abnormal_chemical_nociception3.76256778
7MP0003635_abnormal_synaptic_transmissio3.55683749
8MP0003283_abnormal_digestive_organ3.43982080
9MP0002734_abnormal_mechanical_nocicepti3.12457808
10MP0009745_abnormal_behavioral_response3.03695356
11MP0003195_calcinosis3.01753159
12MP0002736_abnormal_nociception_after2.97709779
13* MP0002063_abnormal_learning/memory/cond2.90733872
14MP0009046_muscle_twitch2.77565988
15MP0005423_abnormal_somatic_nervous2.71353656
16MP0002064_seizures2.69568292
17MP0010386_abnormal_urinary_bladder2.67060909
18MP0002733_abnormal_thermal_nociception2.57402564
19* MP0002572_abnormal_emotion/affect_behav2.56738798
20MP0001970_abnormal_pain_threshold2.51459319
21MP0010234_abnormal_vibrissa_follicle2.48229677
22MP0008877_abnormal_DNA_methylation2.44348610
23MP0003122_maternal_imprinting2.43343786
24MP0002272_abnormal_nervous_system2.30720014
25* MP0001440_abnormal_grooming_behavior2.30536105
26MP0001486_abnormal_startle_reflex2.29977762
27MP0002067_abnormal_sensory_capabilities2.15043558
28MP0002638_abnormal_pupillary_reflex2.11832614
29MP0002184_abnormal_innervation2.10789802
30MP0000778_abnormal_nervous_system2.10719566
31MP0004858_abnormal_nervous_system2.09163054
32MP0001944_abnormal_pancreas_morphology2.08424783
33MP0002693_abnormal_pancreas_physiology1.93582450
34MP0005386_behavior/neurological_phenoty1.90832198
35MP0004924_abnormal_behavior1.90832198
36MP0001501_abnormal_sleep_pattern1.89083628
37MP0002928_abnormal_bile_duct1.83037012
38MP0002102_abnormal_ear_morphology1.80638794
39MP0001529_abnormal_vocalization1.79128455
40MP0003329_amyloid_beta_deposits1.74719139
41* MP0002557_abnormal_social/conspecific_i1.68189893
42MP0004811_abnormal_neuron_physiology1.62220842
43MP0009780_abnormal_chondrocyte_physiolo1.58916544
44MP0005220_abnormal_exocrine_pancreas1.53358603
45MP0004142_abnormal_muscle_tone1.51570571
46MP0003011_delayed_dark_adaptation1.51474041
47MP0001986_abnormal_taste_sensitivity1.49079999
48MP0004145_abnormal_muscle_electrophysio1.46624574
49MP0001984_abnormal_olfaction1.46303632
50MP0001905_abnormal_dopamine_level1.45576333
51MP0000955_abnormal_spinal_cord1.45222980
52MP0002909_abnormal_adrenal_gland1.42364978
53MP0002882_abnormal_neuron_morphology1.42129108
54MP0001502_abnormal_circadian_rhythm1.41571311
55MP0005645_abnormal_hypothalamus_physiol1.39734082
56MP0005646_abnormal_pituitary_gland1.35614279
57MP0000751_myopathy1.33388845
58* MP0002066_abnormal_motor_capabilities/c1.32923294
59MP0008569_lethality_at_weaning1.30190117
60MP0004742_abnormal_vestibular_system1.26752926
61MP0002078_abnormal_glucose_homeostasis1.26609164
62MP0003879_abnormal_hair_cell1.21002210
63MP0002837_dystrophic_cardiac_calcinosis1.19936708
64MP0000427_abnormal_hair_cycle1.19136563
65MP0000462_abnormal_digestive_system1.13261757
66MP0005253_abnormal_eye_physiology1.11586088
67MP0000013_abnormal_adipose_tissue1.10543610
68MP0001188_hyperpigmentation1.10113528
69MP0002090_abnormal_vision1.08395152
70MP0008872_abnormal_physiological_respon1.06610728
71MP0003633_abnormal_nervous_system1.04299985
72MP0002751_abnormal_autonomic_nervous1.03182075
73MP0004043_abnormal_pH_regulation1.02655838
74MP0004134_abnormal_chest_morphology1.00455286
75MP0002152_abnormal_brain_morphology1.00206598
76MP0002229_neurodegeneration0.95269288
77MP0000516_abnormal_urinary_system0.93062895
78MP0005367_renal/urinary_system_phenotyp0.93062895
79MP0003890_abnormal_embryonic-extraembry0.91406406
80MP0002938_white_spotting0.91219130
81MP0000569_abnormal_digit_pigmentation0.90958055
82MP0003631_nervous_system_phenotype0.89446650
83MP0003787_abnormal_imprinting0.89064061
84MP0004885_abnormal_endolymph0.88967092
85MP0002752_abnormal_somatic_nervous0.87130012
86MP0002822_catalepsy0.86361331
87MP0001963_abnormal_hearing_physiology0.85979767
88MP0001756_abnormal_urination0.85452122
89MP0003121_genomic_imprinting0.85448341
90* MP0003953_abnormal_hormone_level0.84425802
91MP0002069_abnormal_eating/drinking_beha0.83741231
92MP0002160_abnormal_reproductive_system0.81460674
93MP0003119_abnormal_digestive_system0.80112086
94MP0000604_amyloidosis0.79926262
95MP0003634_abnormal_glial_cell0.77025297
96MP0004133_heterotaxia0.76787758
97MP0005551_abnormal_eye_electrophysiolog0.75460407
98MP0004085_abnormal_heartbeat0.74034809
99MP0000538_abnormal_urinary_bladder0.73693329
100MP0006072_abnormal_retinal_apoptosis0.72978777
101MP0000631_abnormal_neuroendocrine_gland0.72478429
102MP0004484_altered_response_of0.71659647
103MP0002876_abnormal_thyroid_physiology0.71287508
104MP0000639_abnormal_adrenal_gland0.71095933
105* MP0005535_abnormal_body_temperature0.70345513
106MP0005499_abnormal_olfactory_system0.68840666
107MP0005394_taste/olfaction_phenotype0.68840666
108MP0010678_abnormal_skin_adnexa0.68418548
109MP0008874_decreased_physiological_sensi0.67748720
110MP0004510_myositis0.67401487
111MP0001485_abnormal_pinna_reflex0.66585171
112MP0000003_abnormal_adipose_tissue0.66514473
113MP0005389_reproductive_system_phenotype0.65628246
114MP0001299_abnormal_eye_distance/0.64978025
115MP0008961_abnormal_basal_metabolism0.63972103
116MP0005623_abnormal_meninges_morphology0.62748356
117MP0001348_abnormal_lacrimal_gland0.61583108
118MP0003137_abnormal_impulse_conducting0.61513807
119MP0002163_abnormal_gland_morphology0.60784311
120MP0003632_abnormal_nervous_system0.59845735
121MP0001943_abnormal_respiration0.59432628
122MP0000026_abnormal_inner_ear0.58879762
123MP0005448_abnormal_energy_balance0.58591848
124MP0001664_abnormal_digestion0.57098031
125MP0000920_abnormal_myelination0.55545820
126MP0003861_abnormal_nervous_system0.54789716
127MP0003123_paternal_imprinting0.53891601
128MP0009379_abnormal_foot_pigmentation0.53883922
129MP0005410_abnormal_fertilization0.52826670
130MP0006035_abnormal_mitochondrial_morpho0.51800006
131MP0004233_abnormal_muscle_weight0.49580458
132MP0003183_abnormal_peptide_metabolism0.49369199
133MP0005379_endocrine/exocrine_gland_phen0.49239487

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)8.15394711
2Hyperinsulinemic hypoglycemia (HP:0000825)7.45231851
3Focal motor seizures (HP:0011153)6.71470358
4Hypoglycemic coma (HP:0001325)6.69488171
5Myokymia (HP:0002411)6.08661060
6Ketoacidosis (HP:0001993)5.91976682
7Abnormality of endocrine pancreas physiology (HP:0012093)5.50718431
8Abnormality of the pancreatic islet cells (HP:0006476)5.50718431
9Focal seizures (HP:0007359)5.29999463
10Symptomatic seizures (HP:0011145)5.14668849
11Visual hallucinations (HP:0002367)4.94877717
12Hyperglycemia (HP:0003074)4.78872226
13Epileptic encephalopathy (HP:0200134)4.70297371
14Prominent metopic ridge (HP:0005487)4.63168313
15Atonic seizures (HP:0010819)4.55807381
16Abnormal pancreas size (HP:0012094)4.27173229
17Progressive cerebellar ataxia (HP:0002073)4.26685822
18Abnormality of the metopic suture (HP:0005556)4.20624344
19Absence seizures (HP:0002121)4.20076591
20Supranuclear gaze palsy (HP:0000605)4.07121555
21Neoplasm of the adrenal cortex (HP:0100641)4.05625657
22Polyphagia (HP:0002591)3.91684999
23Abnormal eating behavior (HP:0100738)3.89558505
24Dialeptic seizures (HP:0011146)3.87846018
25Febrile seizures (HP:0002373)3.85837467
26Generalized tonic-clonic seizures (HP:0002069)3.76937244
27Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.65346749
28Ketosis (HP:0001946)3.65128428
29Large for gestational age (HP:0001520)3.64068215
30Mutism (HP:0002300)3.59454371
31Termporal pattern (HP:0011008)3.56499181
32Insidious onset (HP:0003587)3.56499181
33Insulin-resistant diabetes mellitus (HP:0000831)3.55070142
34Failure to thrive in infancy (HP:0001531)3.53211520
35Broad-based gait (HP:0002136)3.45898306
36Limb dystonia (HP:0002451)3.43461409
37Agitation (HP:0000713)3.39394263
38Enlarged penis (HP:0000040)3.34884034
39Action tremor (HP:0002345)3.31689507
40Late onset (HP:0003584)3.31058896
41Papilledema (HP:0001085)3.29097195
42Ankle clonus (HP:0011448)3.25011520
43Abnormality of the corticospinal tract (HP:0002492)3.16285470
44Pheochromocytoma (HP:0002666)3.14822605
45Hypomagnesemia (HP:0002917)3.12594195
46Truncal ataxia (HP:0002078)3.10241391
47Hyperventilation (HP:0002883)3.08605556
48Hepatoblastoma (HP:0002884)3.04401925
49Hypoventilation (HP:0002791)2.98451588
50Hypothermia (HP:0002045)2.94645417
51Excessive salivation (HP:0003781)2.93650651
52Drooling (HP:0002307)2.93650651
53Progressive inability to walk (HP:0002505)2.91859550
54Amblyopia (HP:0000646)2.85070979
55Neuroendocrine neoplasm (HP:0100634)2.84079313
56Urinary bladder sphincter dysfunction (HP:0002839)2.83706641
57Neurofibrillary tangles (HP:0002185)2.76850366
58Pancreatic islet-cell hyperplasia (HP:0004510)2.75780367
59Urinary urgency (HP:0000012)2.74704994
60Impaired vibration sensation in the lower limbs (HP:0002166)2.72300828
61Metaphyseal dysplasia (HP:0100255)2.72140700
62Depression (HP:0000716)2.70662913
63Poor eye contact (HP:0000817)2.69280391
64Increased circulating renin level (HP:0000848)2.67998269
65Type I diabetes mellitus (HP:0100651)2.65462697
66Abnormal hair whorl (HP:0010721)2.62711556
67Anxiety (HP:0000739)2.62454771
68Cerebral inclusion bodies (HP:0100314)2.61878633
69Abnormality of magnesium homeostasis (HP:0004921)2.59589711
70Sleep apnea (HP:0010535)2.58145211
71Inability to walk (HP:0002540)2.54909407
72Gait imbalance (HP:0002141)2.53529466
73Muscular hypotonia of the trunk (HP:0008936)2.52182941
74Calf muscle hypertrophy (HP:0008981)2.51941341
75Spastic gait (HP:0002064)2.45169228
76Gaze-evoked nystagmus (HP:0000640)2.44761981
77Ulnar claw (HP:0001178)2.43605366
78Esotropia (HP:0000565)2.41904487
79Fetal akinesia sequence (HP:0001989)2.35651345
80Impaired social interactions (HP:0000735)2.35328643
81Abnormal social behavior (HP:0012433)2.35328643
82Neoplasm of the adrenal gland (HP:0100631)2.34619416
83Dysdiadochokinesis (HP:0002075)2.34286385
84Abnormality of pain sensation (HP:0010832)2.33493352
85Impaired pain sensation (HP:0007328)2.33493352
86Amyotrophic lateral sclerosis (HP:0007354)2.33315988
87Dysmetria (HP:0001310)2.31093757
88Specific learning disability (HP:0001328)2.28779392
89Epileptiform EEG discharges (HP:0011182)2.28209357
90Abnormality of the labia minora (HP:0012880)2.27454085
91Poor suck (HP:0002033)2.27370451
92Hemiparesis (HP:0001269)2.27156099
93Downturned corners of mouth (HP:0002714)2.26908489
94EEG with generalized epileptiform discharges (HP:0011198)2.24604692
95Morphological abnormality of the pyramidal tract (HP:0002062)2.23791970
96Abnormal drinking behavior (HP:0030082)2.23590334
97Polydipsia (HP:0001959)2.23590334
98Lower limb muscle weakness (HP:0007340)2.22739728
99Hyperphosphatemia (HP:0002905)2.20437834
100Genetic anticipation (HP:0003743)2.18908180
101Akinesia (HP:0002304)2.18763492
102Abnormality of the lower motor neuron (HP:0002366)2.18160453
103Macroorchidism (HP:0000053)2.18153606
104Diplopia (HP:0000651)2.17887090
105Abnormality of binocular vision (HP:0011514)2.17887090
106Bradykinesia (HP:0002067)2.17861941
107Muscle hypertrophy of the lower extremities (HP:0008968)2.16532184
108Exotropia (HP:0000577)2.15234341
109Hypsarrhythmia (HP:0002521)2.12107078
110Psychosis (HP:0000709)2.10202301
111Aplasia/Hypoplasia of the brainstem (HP:0007362)2.10134008
112Hypoplasia of the brainstem (HP:0002365)2.10134008
113Degeneration of the lateral corticospinal tracts (HP:0002314)2.08136038
114Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.08136038
115Neoplasm of the peripheral nervous system (HP:0100007)2.08002996
116Scanning speech (HP:0002168)2.07748724
117Postural instability (HP:0002172)2.06680970
118Lissencephaly (HP:0001339)2.05565907
119Hamartoma of the eye (HP:0010568)2.05316177
120Myotonia (HP:0002486)2.04953941
121Oligomenorrhea (HP:0000876)2.04650495
122Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.02742164
123Testicular neoplasm (HP:0010788)2.00812158
124Torticollis (HP:0000473)2.00101531
125Progressive macrocephaly (HP:0004481)1.99530199
126Nephrogenic diabetes insipidus (HP:0009806)1.99012580
127Ventricular fibrillation (HP:0001663)1.97628067
128Neonatal hypoglycemia (HP:0001998)1.97080487
129Hyperthyroidism (HP:0000836)1.97005137
130Narrow nasal bridge (HP:0000446)1.96273018
131Hepatic necrosis (HP:0002605)1.95891375
132Impaired smooth pursuit (HP:0007772)1.94881696
133Protruding tongue (HP:0010808)1.93520682
134Abnormality of calcium-phosphate metabolism (HP:0100530)1.90179995
135Blue irides (HP:0000635)1.88153070
136Abnormality of salivation (HP:0100755)1.88026948
137Delusions (HP:0000746)1.87914618
138Nephronophthisis (HP:0000090)1.87364037
139Generalized myoclonic seizures (HP:0002123)1.86653012
140Menstrual irregularities (HP:0000858)1.86496089
141Lower limb amyotrophy (HP:0007210)1.85763082
142Focal dystonia (HP:0004373)1.85477681
143Medial flaring of the eyebrow (HP:0010747)1.85303391
144Congenital primary aphakia (HP:0007707)1.85110147
145Difficulty running (HP:0009046)1.85006363
146Aqueductal stenosis (HP:0002410)1.81770057
147Genital tract atresia (HP:0001827)1.73914401
148Vaginal atresia (HP:0000148)1.73427225
149Hematochezia (HP:0002573)1.73380180
150Adrenal hypoplasia (HP:0000835)1.73295884
151Intention tremor (HP:0002080)1.71760281
152Insulin resistance (HP:0000855)1.70248150
153Methylmalonic acidemia (HP:0002912)1.69883818
154Abnormality of the renal cortex (HP:0011035)1.67306100
155Hypogonadotrophic hypogonadism (HP:0000044)1.67187969
156Status epilepticus (HP:0002133)1.65022067
157Abnormal sex determination (HP:0012244)1.64948456
158Sex reversal (HP:0012245)1.64948456
159Restlessness (HP:0000711)1.63190674
160Conjunctival hamartoma (HP:0100780)1.63161601
161Abnormality of renin-angiotensin system (HP:0000847)1.62895955
162Molar tooth sign on MRI (HP:0002419)1.62433732
163Abnormality of midbrain morphology (HP:0002418)1.62433732
164Abnormality of the renal medulla (HP:0100957)1.60653507
165Pancreatic fibrosis (HP:0100732)1.58729690
166Hypokinesia (HP:0002375)1.56055489
167Asymmetry of the thorax (HP:0001555)1.55081705
168Increased density of long bones (HP:0006392)1.54380175
169Thyroid carcinoma (HP:0002890)1.49497537
170Tachypnea (HP:0002789)1.49445916
171Poor coordination (HP:0002370)1.49138651

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.51152174
2MAP3K94.40398305
3MARK14.39412125
4NTRK33.76967334
5PASK3.34282821
6MAP3K123.21688690
7CASK3.20324165
8MINK12.93306833
9MAP3K42.85039750
10NTRK22.46590964
11MAP2K72.46429163
12NTRK12.39265508
13EPHA42.31951722
14TRIM282.29823405
15DAPK22.12051459
16MAP2K42.10029625
17PAK61.88866955
18MAPK131.82073317
19SIK21.79637039
20KSR21.79521672
21UHMK11.79326215
22CDK191.68019114
23SIK31.57511477
24KSR11.53404643
25PINK11.53392568
26LATS21.51238302
27TNIK1.46302171
28GRK51.46123941
29PNCK1.45956762
30PHKG21.44907528
31PHKG11.44907528
32CDK51.43573124
33BCR1.42747401
34FGFR31.38828159
35ADRBK21.35486926
36DAPK11.27571651
37LIMK11.21481248
38PLK21.15574903
39HIPK21.13976666
40WNK41.12690996
41RIPK41.09285474
42MAP3K21.03310011
43RET1.03158053
44PRKCG1.02874361
45CDK181.01978910
46PAK31.01259251
47NLK1.01050749
48GRK11.00753050
49CSNK1G11.00595853
50INSRR1.00309805
51CSNK1G20.99602290
52CDK140.99407923
53ARAF0.98616833
54CCNB10.97861334
55CAMK2A0.96185719
56ACVR1B0.94555853
57CDK150.93082437
58LMTK20.92625242
59SGK30.92150265
60DYRK20.91843012
61PRKAA10.91496616
62WNK30.90638954
63PRKAA20.89937829
64ZAK0.87976116
65STK390.87579423
66CAMKK10.86718077
67TYRO30.86027672
68FGFR20.83751184
69OXSR10.83310112
70AKT30.81451006
71STK38L0.81187102
72FER0.80888826
73CDK11A0.79791035
74PRPF4B0.79299379
75STK380.76377367
76MAP4K20.73968453
77NUAK10.72936195
78EPHB20.72876510
79GRK70.71817605
80FES0.68599891
81CSNK1G30.68299269
82CAMKK20.67615658
83CDK30.67594997
84PRKCE0.64701481
85ADRBK10.62892250
86CAMK2B0.61349392
87DYRK1A0.60510843
88SGK2230.60225530
89SGK4940.60225530
90TAOK10.58171356
91STK160.57481610
92ERBB30.57213573
93MARK20.56425523
94STK110.56084292
95SCYL20.55544826
96TNK20.55312313
97BMPR1B0.53519725
98PRKCZ0.51389544
99RPS6KA20.49489321
100MAP3K10.49230421
101STK240.49190298
102EPHA30.49004824
103CAMK1G0.48024119
104CSNK1E0.45654169
105CAMK1D0.44520722
106CAMK2D0.43677097
107MAP3K70.43549592
108ROCK20.43468351
109STK30.43000180
110NME10.42843086
111MAP2K60.42842965
112MAPK150.42081444
113CAMK10.41732122
114FYN0.41381537
115MAPK120.40402786
116DAPK30.39775526
117PRKG10.39386583
118PRKD30.39094193
119CSNK1A1L0.36968173
120CSNK1A10.36717592
121MAP2K10.36172968
122PRKCH0.34083169
123CAMK2G0.33299676
124CDC42BPA0.33151945
125PRKCA0.33101099
126MKNK20.33051544
127DYRK30.32292793
128SGK20.32218663
129WNK10.31572800
130CSNK1D0.31547436
131PTK2B0.30847005
132MATK0.30707965
133SGK10.30196080
134FGR0.30063555
135PLK30.29954759
136RPS6KA30.29734297
137MAPK100.29097477
138MAPK40.28748510
139TRPM70.28564701
140IRAK10.28344949
141PRKACA0.28280715
142MAP3K130.28165639
143MAP3K110.27577283

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.38908861
2Nicotine addiction_Homo sapiens_hsa050333.98510325
3Synaptic vesicle cycle_Homo sapiens_hsa047213.70911422
4Butanoate metabolism_Homo sapiens_hsa006502.78329015
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.62408208
6GABAergic synapse_Homo sapiens_hsa047272.61296421
7Protein export_Homo sapiens_hsa030602.43549880
8Regulation of autophagy_Homo sapiens_hsa041402.34968560
9Morphine addiction_Homo sapiens_hsa050322.30355144
10Olfactory transduction_Homo sapiens_hsa047402.29488740
11Circadian entrainment_Homo sapiens_hsa047132.28135189
12Glutamatergic synapse_Homo sapiens_hsa047242.26252977
13Long-term potentiation_Homo sapiens_hsa047202.20695924
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.20468868
15Collecting duct acid secretion_Homo sapiens_hsa049662.12879416
16Dopaminergic synapse_Homo sapiens_hsa047282.08384682
17Amphetamine addiction_Homo sapiens_hsa050312.07121908
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.98095219
19Taste transduction_Homo sapiens_hsa047421.95469217
20* Insulin secretion_Homo sapiens_hsa049111.81929416
21Salivary secretion_Homo sapiens_hsa049701.79437443
22Gastric acid secretion_Homo sapiens_hsa049711.79265002
23Cocaine addiction_Homo sapiens_hsa050301.76925385
24Cholinergic synapse_Homo sapiens_hsa047251.73020356
25Serotonergic synapse_Homo sapiens_hsa047261.72394553
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61466072
27Oxidative phosphorylation_Homo sapiens_hsa001901.61374533
28Long-term depression_Homo sapiens_hsa047301.59977813
29Axon guidance_Homo sapiens_hsa043601.56420386
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.55440994
31Cardiac muscle contraction_Homo sapiens_hsa042601.52842008
32* Renin secretion_Homo sapiens_hsa049241.47878561
33Oxytocin signaling pathway_Homo sapiens_hsa049211.44691393
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43446490
35Vibrio cholerae infection_Homo sapiens_hsa051101.41535373
36GnRH signaling pathway_Homo sapiens_hsa049121.41262569
37Gap junction_Homo sapiens_hsa045401.38773155
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33166897
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28729725
40Parkinsons disease_Homo sapiens_hsa050121.28562052
41Vitamin B6 metabolism_Homo sapiens_hsa007501.25623761
42Estrogen signaling pathway_Homo sapiens_hsa049151.23167988
43Calcium signaling pathway_Homo sapiens_hsa040201.22608117
44Alzheimers disease_Homo sapiens_hsa050101.20732868
45Circadian rhythm_Homo sapiens_hsa047101.16751110
46Type I diabetes mellitus_Homo sapiens_hsa049401.16749517
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15610335
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15458805
49Fatty acid elongation_Homo sapiens_hsa000621.14619609
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09999167
51Tryptophan metabolism_Homo sapiens_hsa003801.09247809
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08888118
53ErbB signaling pathway_Homo sapiens_hsa040121.07770449
54cAMP signaling pathway_Homo sapiens_hsa040241.07420452
55Oocyte meiosis_Homo sapiens_hsa041141.02442372
56Melanogenesis_Homo sapiens_hsa049161.00845407
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00352132
58Glioma_Homo sapiens_hsa052141.00124128
59Type II diabetes mellitus_Homo sapiens_hsa049300.96364945
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95436079
61Dorso-ventral axis formation_Homo sapiens_hsa043200.93400861
62Huntingtons disease_Homo sapiens_hsa050160.90560297
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88534639
64Fatty acid metabolism_Homo sapiens_hsa012120.88358938
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.81416685
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81033023
67MAPK signaling pathway_Homo sapiens_hsa040100.78225455
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76420928
69Phototransduction_Homo sapiens_hsa047440.75072749
70Peroxisome_Homo sapiens_hsa041460.73468388
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72666190
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71579575
73Dilated cardiomyopathy_Homo sapiens_hsa054140.71393614
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69074919
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.68257925
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66836687
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.66651109
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66316293
79AMPK signaling pathway_Homo sapiens_hsa041520.65628928
80Prion diseases_Homo sapiens_hsa050200.65487111
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64886551
82Insulin signaling pathway_Homo sapiens_hsa049100.62170097
83VEGF signaling pathway_Homo sapiens_hsa043700.60891717
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60752615
85Ras signaling pathway_Homo sapiens_hsa040140.59474371
86Thyroid hormone synthesis_Homo sapiens_hsa049180.59125128
87ABC transporters_Homo sapiens_hsa020100.57630078
88Renal cell carcinoma_Homo sapiens_hsa052110.57094794
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.56952138
90Alcoholism_Homo sapiens_hsa050340.56340670
91Choline metabolism in cancer_Homo sapiens_hsa052310.56331746
92Pancreatic secretion_Homo sapiens_hsa049720.53522612
93Propanoate metabolism_Homo sapiens_hsa006400.53395578
94Sulfur metabolism_Homo sapiens_hsa009200.52319557
95Phagosome_Homo sapiens_hsa041450.52105290
96beta-Alanine metabolism_Homo sapiens_hsa004100.51998507
97Endometrial cancer_Homo sapiens_hsa052130.51592445
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51581821
99Ether lipid metabolism_Homo sapiens_hsa005650.50694629
100Mineral absorption_Homo sapiens_hsa049780.50592213
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50517747
102Fatty acid degradation_Homo sapiens_hsa000710.50446683
103Insulin resistance_Homo sapiens_hsa049310.49977080
104Glucagon signaling pathway_Homo sapiens_hsa049220.48906073
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48124820
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47557015
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47137797
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45427597
109Bile secretion_Homo sapiens_hsa049760.44267290
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43598608
111Endocytosis_Homo sapiens_hsa041440.43539784
112Rheumatoid arthritis_Homo sapiens_hsa053230.43074937
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41282759
114Rap1 signaling pathway_Homo sapiens_hsa040150.38948988
115Primary bile acid biosynthesis_Homo sapiens_hsa001200.38038610
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36769961
117Folate biosynthesis_Homo sapiens_hsa007900.35728424
118Colorectal cancer_Homo sapiens_hsa052100.35148696
119Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33392311
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33186610
121Wnt signaling pathway_Homo sapiens_hsa043100.32925835
122Linoleic acid metabolism_Homo sapiens_hsa005910.32862092
123FoxO signaling pathway_Homo sapiens_hsa040680.32640300
124Sphingolipid metabolism_Homo sapiens_hsa006000.32003998
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31909746
126Prolactin signaling pathway_Homo sapiens_hsa049170.31633070
127Selenocompound metabolism_Homo sapiens_hsa004500.30899587
128Starch and sucrose metabolism_Homo sapiens_hsa005000.30584103
129Ovarian steroidogenesis_Homo sapiens_hsa049130.30413377
130mTOR signaling pathway_Homo sapiens_hsa041500.29809143
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29747493
132Melanoma_Homo sapiens_hsa052180.26893095
133Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26424833
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25674623
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24997387

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