ADCYAP1R1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)6.00768273
2axon ensheathment in central nervous system (GO:0032291)6.00768273
3locomotory exploration behavior (GO:0035641)5.92085854
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.82107942
5synaptic vesicle maturation (GO:0016188)5.34555232
6vocalization behavior (GO:0071625)5.17768152
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.15512497
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.15434006
9gamma-aminobutyric acid transport (GO:0015812)4.86371751
10neuron cell-cell adhesion (GO:0007158)4.81538780
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.80578411
12regulation of glutamate receptor signaling pathway (GO:1900449)4.80210232
13synaptic vesicle exocytosis (GO:0016079)4.70538673
14glutamate secretion (GO:0014047)4.68561629
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.59971433
16layer formation in cerebral cortex (GO:0021819)4.58001772
17regulation of synaptic vesicle exocytosis (GO:2000300)4.45147912
18auditory behavior (GO:0031223)4.43399168
19neurotransmitter secretion (GO:0007269)4.42966214
20cellular potassium ion homeostasis (GO:0030007)4.40959032
21exploration behavior (GO:0035640)4.39636657
22neurotransmitter uptake (GO:0001504)4.36453473
23synaptic vesicle docking involved in exocytosis (GO:0016081)4.34212580
24response to auditory stimulus (GO:0010996)4.33605766
25sodium ion export (GO:0071436)4.28259444
26astrocyte differentiation (GO:0048708)4.26350552
27neurotransmitter-gated ion channel clustering (GO:0072578)4.25564167
28protein localization to synapse (GO:0035418)4.25086076
29regulation of neuronal synaptic plasticity (GO:0048168)4.21328882
30proline transport (GO:0015824)4.20168320
31regulation of synapse structural plasticity (GO:0051823)4.19935589
32dermatan sulfate biosynthetic process (GO:0030208)4.15168924
33regulation of long-term neuronal synaptic plasticity (GO:0048169)4.12867083
34synaptic transmission, glutamatergic (GO:0035249)4.06186545
35glutamate receptor signaling pathway (GO:0007215)4.00062025
36dendritic spine morphogenesis (GO:0060997)3.97240027
37regulation of synaptic vesicle transport (GO:1902803)3.96413409
38neuronal action potential propagation (GO:0019227)3.89471233
39photoreceptor cell differentiation (GO:0046530)3.88559855
40eye photoreceptor cell differentiation (GO:0001754)3.88559855
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.88323350
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.86801425
43dermatan sulfate metabolic process (GO:0030205)3.83134884
44cell communication by electrical coupling (GO:0010644)3.81840660
45positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.76476090
46long-term memory (GO:0007616)3.73368158
47innervation (GO:0060384)3.72826308
48L-amino acid import (GO:0043092)3.67695647
49postsynaptic membrane organization (GO:0001941)3.67171347
50cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.66671207
51neuron-neuron synaptic transmission (GO:0007270)3.65941736
52neurotransmitter transport (GO:0006836)3.65074104
53oligodendrocyte differentiation (GO:0048709)3.62165550
54astrocyte development (GO:0014002)3.57484438
55regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.56677719
56regulation of neurotransmitter uptake (GO:0051580)3.56486846
57positive regulation of synaptic transmission, GABAergic (GO:0032230)3.50078675
58cGMP-mediated signaling (GO:0019934)3.46163162
59transmission of nerve impulse (GO:0019226)3.45534945
60regulation of synaptic transmission, glutamatergic (GO:0051966)3.43779731
61neuron recognition (GO:0008038)3.43517763
62regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.42731054
63regulation of neurotransmitter levels (GO:0001505)3.41592614
64acidic amino acid transport (GO:0015800)3.41474632
65dendrite morphogenesis (GO:0048813)3.41408897
66prepulse inhibition (GO:0060134)3.40563867
67mechanosensory behavior (GO:0007638)3.40303045
68positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.40205938
69chondroitin sulfate catabolic process (GO:0030207)3.39057416
70startle response (GO:0001964)3.38027580
71one-carbon compound transport (GO:0019755)3.36767443
72neuromuscular process controlling balance (GO:0050885)3.36719840
73glycine transport (GO:0015816)3.35080079
74positive regulation of membrane potential (GO:0045838)3.34952184
75amino acid import (GO:0043090)3.34914513
76axonal fasciculation (GO:0007413)3.34359297
77activation of protein kinase A activity (GO:0034199)3.32646051
78regulation of excitatory postsynaptic membrane potential (GO:0060079)3.32009179
79negative regulation of synaptic transmission, GABAergic (GO:0032229)3.31133237
80alanine transport (GO:0032328)3.29232320
81positive regulation of synapse maturation (GO:0090129)3.29162413
82neuron projection regeneration (GO:0031102)3.27973298
83cellular sodium ion homeostasis (GO:0006883)3.27169713
84establishment of mitochondrion localization (GO:0051654)3.26660694
85regulation of synaptic plasticity (GO:0048167)3.26314571
86cerebellar granule cell differentiation (GO:0021707)3.23836354
87regulation of female receptivity (GO:0045924)3.22867116
88potassium ion import (GO:0010107)3.22554491
89long-term synaptic potentiation (GO:0060291)3.21391227
90regulation of postsynaptic membrane potential (GO:0060078)3.19394973
91synaptic vesicle endocytosis (GO:0048488)3.18949028
92pyrimidine nucleobase catabolic process (GO:0006208)3.18474046
93presynaptic membrane assembly (GO:0097105)3.16565608
94neuromuscular process controlling posture (GO:0050884)3.16400520
95membrane assembly (GO:0071709)3.15678304
96regulation of respiratory system process (GO:0044065)3.13606418
97cerebellar Purkinje cell differentiation (GO:0021702)3.13349038
98regulation of neurotransmitter secretion (GO:0046928)3.13024080
99neuronal ion channel clustering (GO:0045161)3.12630292
100synapse assembly (GO:0007416)3.11352281
101negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.09950063
102negative regulation of astrocyte differentiation (GO:0048712)3.08983196
103regulation of dendritic spine morphogenesis (GO:0061001)3.07591606
104G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.07269049
105gamma-aminobutyric acid signaling pathway (GO:0007214)3.07235164
106potassium ion homeostasis (GO:0055075)3.06275312
107regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.04624799
108negative regulation of cytosolic calcium ion concentration (GO:0051481)3.03014180
109L-glutamate transport (GO:0015813)3.02873280
110positive regulation of potassium ion transmembrane transport (GO:1901381)3.00716290
111presynaptic membrane organization (GO:0097090)3.00331387
112regulation of neurotransmitter transport (GO:0051588)2.98083546
113synapse organization (GO:0050808)2.95568443
114negative regulation of neurotransmitter transport (GO:0051589)2.95427373
115positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.94972076
116membrane hyperpolarization (GO:0060081)2.94790668
117glial cell differentiation (GO:0010001)2.93639223
118regulation of vesicle fusion (GO:0031338)2.93128932
119positive regulation of synaptic transmission (GO:0050806)2.93068537
120myelination (GO:0042552)2.92970821
121enteric nervous system development (GO:0048484)2.91140655
122neuromuscular process (GO:0050905)2.90543132
123negative regulation of sodium ion transport (GO:0010766)2.90471051
124negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.89978418
125regulation of synaptic transmission (GO:0050804)2.88564802
126membrane depolarization during action potential (GO:0086010)2.88418010
127hyperosmotic salinity response (GO:0042538)2.87418572
128cellular response to cholesterol (GO:0071397)2.86801825
129negative regulation of dendrite development (GO:2000171)2.86228826
130positive regulation of synapse assembly (GO:0051965)2.84396441
131axon ensheathment (GO:0008366)2.83147009
132ensheathment of neurons (GO:0007272)2.83147009
133cerebellar Purkinje cell layer development (GO:0021680)2.81748402

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.98238276
2GBX2_23144817_ChIP-Seq_PC3_Human3.35903260
3* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.13216377
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11592506
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09396269
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.81155062
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.81155062
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.74008337
9* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.72126944
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62746085
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.62434387
12* REST_21632747_ChIP-Seq_MESCs_Mouse2.61997535
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.55334270
14* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54949749
15DROSHA_22980978_ChIP-Seq_HELA_Human2.52101357
16* EED_16625203_ChIP-ChIP_MESCs_Mouse2.51694559
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47577298
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.32740846
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.29317198
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.27622457
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27615359
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.23046965
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20840343
24AR_21572438_ChIP-Seq_LNCaP_Human2.18924631
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.14426503
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.11003812
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07216971
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97256631
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.92115613
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86609579
31RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.79055953
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77189861
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.69787425
34PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56403167
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51060220
36RING1B_27294783_Chip-Seq_ESCs_Mouse1.50924310
37SMAD4_21799915_ChIP-Seq_A2780_Human1.50824176
38* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.48847168
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47754734
40* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47613974
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.45584009
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41934119
43ZNF274_21170338_ChIP-Seq_K562_Hela1.37003491
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36747434
45SOX2_21211035_ChIP-Seq_LN229_Gbm1.30406533
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28385989
47P300_19829295_ChIP-Seq_ESCs_Human1.27878533
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26860908
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.26515967
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.25981417
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25024272
52AR_19668381_ChIP-Seq_PC3_Human1.24876263
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23173031
54* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21106123
55TAF15_26573619_Chip-Seq_HEK293_Human1.21039440
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19656323
57RING1B_27294783_Chip-Seq_NPCs_Mouse1.19557965
58RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19051329
59AR_25329375_ChIP-Seq_VCAP_Human1.18931772
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17867910
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.16970135
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15145226
63STAT3_23295773_ChIP-Seq_U87_Human1.14060383
64CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13957907
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13950909
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10628515
67* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09601907
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09413482
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07927070
70GATA1_26923725_Chip-Seq_HPCs_Mouse1.07661833
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05608825
72YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05449722
73KDM2B_26808549_Chip-Seq_K562_Human1.05044043
74MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04662074
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03750668
76LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02971568
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02743861
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.01122618
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01097450
80* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00640969
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99584011
82TRIM28_21343339_ChIP-Seq_HEK293_Human0.98695706
83SMAD3_21741376_ChIP-Seq_ESCs_Human0.97997544
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97444457
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97363275
86RNF2_27304074_Chip-Seq_NSC_Mouse0.96619089
87AHR_22903824_ChIP-Seq_MCF-7_Human0.96385099
88EP300_21415370_ChIP-Seq_HL-1_Mouse0.96014072
89P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95589022
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95273374
91SMAD4_21741376_ChIP-Seq_HESCs_Human0.95172275
92TCF4_23295773_ChIP-Seq_U87_Human0.95010710
93KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94189678
94SOX9_26525672_Chip-Seq_HEART_Mouse0.94018535
95RUNX2_22187159_ChIP-Seq_PCA_Human0.93430446
96TP53_20018659_ChIP-ChIP_R1E_Mouse0.93089608
97STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92581305
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92491390
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91408862
100RXR_22108803_ChIP-Seq_LS180_Human0.91367710
101TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91163674
102SMAD3_21741376_ChIP-Seq_HESCs_Human0.90296704
103IGF1R_20145208_ChIP-Seq_DFB_Human0.89903960
104POU5F1_16518401_ChIP-PET_MESCs_Mouse0.89592998
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88289960
106POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.87830774
107OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86190578
108TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.85145855
109TP53_16413492_ChIP-PET_HCT116_Human0.85032588
110ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84924707
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84555334
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84555334
113TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84253630
114BMI1_23680149_ChIP-Seq_NPCS_Mouse0.84234625
115ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83878110
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83683712
117PRDM14_20953172_ChIP-Seq_ESCs_Human0.83672696
118SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83452269

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.17434732
2MP0003880_abnormal_central_pattern4.26606919
3* MP0003635_abnormal_synaptic_transmissio3.93532632
4MP0005423_abnormal_somatic_nervous3.39655658
5MP0009745_abnormal_behavioral_response3.28272811
6MP0004270_analgesia3.18786007
7* MP0002063_abnormal_learning/memory/cond3.11629587
8MP0002064_seizures3.10506062
9MP0009046_muscle_twitch2.98296643
10MP0001968_abnormal_touch/_nociception2.85850987
11MP0001486_abnormal_startle_reflex2.66212598
12* MP0002572_abnormal_emotion/affect_behav2.65985997
13MP0004858_abnormal_nervous_system2.53123230
14MP0002822_catalepsy2.52452846
15MP0002272_abnormal_nervous_system2.37002355
16MP0002734_abnormal_mechanical_nocicepti2.35591144
17MP0002736_abnormal_nociception_after2.32275780
18MP0005646_abnormal_pituitary_gland2.18972521
19MP0000778_abnormal_nervous_system2.13161845
20MP0001501_abnormal_sleep_pattern2.10012921
21MP0001440_abnormal_grooming_behavior2.07449433
22MP0009780_abnormal_chondrocyte_physiolo1.99523610
23MP0002067_abnormal_sensory_capabilities1.97781052
24MP0002733_abnormal_thermal_nociception1.96279458
25MP0008569_lethality_at_weaning1.96187958
26MP0003329_amyloid_beta_deposits1.89340741
27MP0004885_abnormal_endolymph1.86954874
28MP0002557_abnormal_social/conspecific_i1.84580304
29MP0001970_abnormal_pain_threshold1.83916118
30MP0005645_abnormal_hypothalamus_physiol1.75706118
31MP0002735_abnormal_chemical_nociception1.75544757
32MP0002184_abnormal_innervation1.73175207
33MP0001984_abnormal_olfaction1.69316216
34MP0004811_abnormal_neuron_physiology1.65173188
35MP0000955_abnormal_spinal_cord1.64527556
36MP0004924_abnormal_behavior1.60845834
37MP0005386_behavior/neurological_phenoty1.60845834
38MP0003690_abnormal_glial_cell1.56917095
39MP0003122_maternal_imprinting1.56019950
40MP0002909_abnormal_adrenal_gland1.55605791
41MP0006276_abnormal_autonomic_nervous1.50435252
42MP0002882_abnormal_neuron_morphology1.43196107
43MP0003633_abnormal_nervous_system1.39121297
44* MP0002066_abnormal_motor_capabilities/c1.37156097
45MP0004142_abnormal_muscle_tone1.36550182
46MP0003787_abnormal_imprinting1.36132809
47MP0000566_synostosis1.32141029
48MP0003634_abnormal_glial_cell1.25156529
49MP0002152_abnormal_brain_morphology1.24661585
50MP0001529_abnormal_vocalization1.22472065
51MP0002653_abnormal_ependyma_morphology1.22144616
52MP0005167_abnormal_blood-brain_barrier1.21614648
53* MP0001502_abnormal_circadian_rhythm1.20156203
54MP0003283_abnormal_digestive_organ1.18933943
55MP0001905_abnormal_dopamine_level1.18484317
56MP0003631_nervous_system_phenotype1.18236774
57MP0000579_abnormal_nail_morphology1.17253010
58MP0008961_abnormal_basal_metabolism1.13978436
59MP0003879_abnormal_hair_cell1.10735366
60MP0002638_abnormal_pupillary_reflex1.04774325
61MP0000631_abnormal_neuroendocrine_gland1.02217367
62MP0000751_myopathy1.01099058
63MP0001177_atelectasis1.01002776
64MP0003632_abnormal_nervous_system0.99137465
65MP0004742_abnormal_vestibular_system0.96006744
66MP0002069_abnormal_eating/drinking_beha0.93732372
67MP0003075_altered_response_to0.93542388
68MP0000920_abnormal_myelination0.92258368
69MP0000569_abnormal_digit_pigmentation0.91532215
70MP0003938_abnormal_ear_development0.91073080
71MP0002249_abnormal_larynx_morphology0.88207739
72MP0001299_abnormal_eye_distance/0.87608902
73MP0001485_abnormal_pinna_reflex0.86004662
74MP0001963_abnormal_hearing_physiology0.85001505
75MP0005551_abnormal_eye_electrophysiolog0.84307500
76MP0002229_neurodegeneration0.84143507
77MP0005499_abnormal_olfactory_system0.83546954
78MP0005394_taste/olfaction_phenotype0.83546954
79MP0002090_abnormal_vision0.81764246
80MP0003878_abnormal_ear_physiology0.81403567
81MP0005377_hearing/vestibular/ear_phenot0.81403567
82MP0005623_abnormal_meninges_morphology0.80161450
83MP0002089_abnormal_postnatal_growth/wei0.78565997
84MP0002752_abnormal_somatic_nervous0.78336661
85MP0008872_abnormal_physiological_respon0.76917439
86MP0000604_amyloidosis0.75418805
87MP0005409_darkened_coat_color0.73953470
88MP0003136_yellow_coat_color0.73291676
89MP0003861_abnormal_nervous_system0.73068725
90MP0001188_hyperpigmentation0.72690132
91MP0003119_abnormal_digestive_system0.72121258
92MP0003137_abnormal_impulse_conducting0.71663316
93MP0005248_abnormal_Harderian_gland0.69792587
94MP0002102_abnormal_ear_morphology0.69428113
95MP0004233_abnormal_muscle_weight0.68978881
96MP0004085_abnormal_heartbeat0.68777544
97MP0004215_abnormal_myocardial_fiber0.67748045
98MP0005171_absent_coat_pigmentation0.67493294
99MP0004043_abnormal_pH_regulation0.67208524
100MP0002751_abnormal_autonomic_nervous0.65478339
101MP0008874_decreased_physiological_sensi0.65254463
102MP0000026_abnormal_inner_ear0.64316339
103MP0003121_genomic_imprinting0.63680615
104MP0003172_abnormal_lysosome_physiology0.63561622
105MP0004130_abnormal_muscle_cell0.61983628
106MP0001943_abnormal_respiration0.61956574
107MP0000462_abnormal_digestive_system0.60455411
108MP0005535_abnormal_body_temperature0.59661728
109MP0000013_abnormal_adipose_tissue0.58858680
110MP0000534_abnormal_ureter_morphology0.57854284
111MP0003183_abnormal_peptide_metabolism0.57055846
112MP0001664_abnormal_digestion0.56757325
113MP0005253_abnormal_eye_physiology0.56626036
114* MP0010769_abnormal_survival0.55713132
115MP0005595_abnormal_vascular_smooth0.55697130
116MP0006072_abnormal_retinal_apoptosis0.55461763
117MP0004133_heterotaxia0.53997764
118* MP0002082_postnatal_lethality0.53238360
119* MP0010770_preweaning_lethality0.53238360
120* MP0010768_mortality/aging0.51977124

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.84402254
2Myokymia (HP:0002411)6.17486904
3Focal seizures (HP:0007359)5.16138236
4Visual hallucinations (HP:0002367)4.38528315
5Epileptic encephalopathy (HP:0200134)4.22135313
6Progressive cerebellar ataxia (HP:0002073)4.07617444
7Action tremor (HP:0002345)3.85340918
8Megalencephaly (HP:0001355)3.85216045
9Split foot (HP:0001839)3.80273758
10Supranuclear gaze palsy (HP:0000605)3.72710149
11Peripheral hypomyelination (HP:0007182)3.66272526
12Atonic seizures (HP:0010819)3.63648020
13Febrile seizures (HP:0002373)3.63376199
14Generalized tonic-clonic seizures (HP:0002069)3.61213321
15Absence seizures (HP:0002121)3.51391776
16Ankle clonus (HP:0011448)3.39143088
17Increased circulating renin level (HP:0000848)3.35625216
18Hemiparesis (HP:0001269)3.33315736
19Oligodactyly (hands) (HP:0001180)3.31129001
20Abnormal eating behavior (HP:0100738)3.29190730
21Hemiplegia (HP:0002301)3.26259498
22Dialeptic seizures (HP:0011146)3.22502332
23Depression (HP:0000716)3.18599386
24Aplasia of the phalanges of the hand (HP:0009802)3.17357876
25Aplasia involving bones of the extremities (HP:0009825)3.17357876
26Aplasia involving bones of the upper limbs (HP:0009823)3.17357876
27Abnormality of binocular vision (HP:0011514)3.11860663
28Diplopia (HP:0000651)3.11860663
29Dysdiadochokinesis (HP:0002075)3.11230759
30Obstructive sleep apnea (HP:0002870)3.06572152
31Neurofibrillary tangles (HP:0002185)3.04538178
32Postural instability (HP:0002172)3.03737665
33Broad-based gait (HP:0002136)2.94383431
34Morphological abnormality of the inner ear (HP:0011390)2.93951517
35Impaired vibration sensation in the lower limbs (HP:0002166)2.92646267
36Urinary bladder sphincter dysfunction (HP:0002839)2.86064475
37Truncal ataxia (HP:0002078)2.85611299
38Partial duplication of thumb phalanx (HP:0009944)2.83712034
39Dysmetria (HP:0001310)2.79987477
40Anxiety (HP:0000739)2.79889175
41Alacrima (HP:0000522)2.79066842
42Poor eye contact (HP:0000817)2.77398589
43Abnormality of the diencephalon (HP:0010662)2.75149918
44Mutism (HP:0002300)2.74351089
45Polyphagia (HP:0002591)2.73128344
46Abnormality of the 4th metacarpal (HP:0010012)2.72629916
47Hyperventilation (HP:0002883)2.70925744
48Spastic gait (HP:0002064)2.64981629
49Abnormality of cochlea (HP:0000375)2.61328121
50Cerebral inclusion bodies (HP:0100314)2.60510982
51Insomnia (HP:0100785)2.58018167
52Abnormal social behavior (HP:0012433)2.57031603
53Impaired social interactions (HP:0000735)2.57031603
54Gaze-evoked nystagmus (HP:0000640)2.57019274
55Urinary urgency (HP:0000012)2.56072188
56Papilledema (HP:0001085)2.55946450
57Sleep apnea (HP:0010535)2.53019574
58Torticollis (HP:0000473)2.44701273
59Intention tremor (HP:0002080)2.44400167
60Partial duplication of the phalanx of hand (HP:0009999)2.40752349
61Progressive inability to walk (HP:0002505)2.38654384
62Excessive salivation (HP:0003781)2.38232856
63Drooling (HP:0002307)2.38232856
64Oligodactyly (HP:0012165)2.38021446
65Anomalous pulmonary venous return (HP:0010772)2.36167240
66Genetic anticipation (HP:0003743)2.34616107
67Status epilepticus (HP:0002133)2.33726147
68Akinesia (HP:0002304)2.33382391
69Lower limb muscle weakness (HP:0007340)2.33139812
70Turricephaly (HP:0000262)2.29286318
71Bradykinesia (HP:0002067)2.27452177
72Urethral obstruction (HP:0000796)2.23187719
73Focal dystonia (HP:0004373)2.17015608
74Pointed chin (HP:0000307)2.16927562
75Stereotypic behavior (HP:0000733)2.16373483
76Aqueductal stenosis (HP:0002410)2.15921936
77Pheochromocytoma (HP:0002666)2.15270768
78Scanning speech (HP:0002168)2.13840374
79Amblyopia (HP:0000646)2.12971820
80Decreased lacrimation (HP:0000633)2.12898458
81Epileptiform EEG discharges (HP:0011182)2.10239709
82EEG with generalized epileptiform discharges (HP:0011198)2.07942376
83Limb dystonia (HP:0002451)2.06565525
84Bowel incontinence (HP:0002607)2.04697695
85Abnormality of the lower motor neuron (HP:0002366)2.04250370
86Ventricular fibrillation (HP:0001663)2.03930727
87Hypsarrhythmia (HP:0002521)2.03439317
88Impaired smooth pursuit (HP:0007772)2.01542921
89Abnormality of the pulmonary veins (HP:0011718)2.01406422
90Agitation (HP:0000713)1.99189312
91Cutaneous finger syndactyly (HP:0010554)1.97994055
92Abnormality of ocular smooth pursuit (HP:0000617)1.96496191
93Esophageal atresia (HP:0002032)1.92890190
94Gait ataxia (HP:0002066)1.91997283
95Craniofacial dystonia (HP:0012179)1.91976740
96Narrow nasal bridge (HP:0000446)1.90300951
97Impaired vibratory sensation (HP:0002495)1.90007854
98Fetal akinesia sequence (HP:0001989)1.89743802
99Coronal craniosynostosis (HP:0004440)1.88675552
100Synostosis of carpal bones (HP:0005048)1.88657439
101Thickened helices (HP:0000391)1.87288296
102Blue irides (HP:0000635)1.83036242
103Neuronal loss in central nervous system (HP:0002529)1.82959712
104Humeroradial synostosis (HP:0003041)1.82945851
105Synostosis involving the elbow (HP:0003938)1.82945851
106Abnormal large intestine physiology (HP:0012700)1.82405840
107Neoplasm of the heart (HP:0100544)1.82312885
108Fibular hypoplasia (HP:0003038)1.82296625
109Abnormality of the corticospinal tract (HP:0002492)1.81565621
110Clonus (HP:0002169)1.81284465
111Metabolic alkalosis (HP:0200114)1.81153985
112Elfin facies (HP:0004428)1.81027813
113Overriding aorta (HP:0002623)1.80447740
114Bronchomalacia (HP:0002780)1.79692313
115Ankyloglossia (HP:0010296)1.78608543
116Septo-optic dysplasia (HP:0100842)1.78545887
117Incomplete penetrance (HP:0003829)1.78438970
118Cutaneous syndactyly (HP:0012725)1.78353522
119Neuroendocrine neoplasm (HP:0100634)1.78252169
120Hyperacusis (HP:0010780)1.77823350
121Psychosis (HP:0000709)1.77402740
122Absent speech (HP:0001344)1.76154328
123Specific learning disability (HP:0001328)1.75709113
124Anophthalmia (HP:0000528)1.74393353
125Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.74310768
126Generalized myoclonic seizures (HP:0002123)1.73910871
127Clumsiness (HP:0002312)1.71691392
128Failure to thrive in infancy (HP:0001531)1.71575983
129Rigidity (HP:0002063)1.71318372
130Termporal pattern (HP:0011008)1.70460456
131Insidious onset (HP:0003587)1.70460456
132Tetraplegia (HP:0002445)1.69596034
133Mixed hearing impairment (HP:0000410)1.67161572
134Hypoventilation (HP:0002791)1.66307809
135Hypoplasia of the corpus callosum (HP:0002079)1.65455400
136Heterochromia iridis (HP:0001100)1.64358081
137Gastrointestinal atresia (HP:0002589)1.61175475
138Spastic tetraparesis (HP:0001285)1.60006293
139Degeneration of the lateral corticospinal tracts (HP:0002314)1.59659393

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.29130502
2EPHA43.68161704
3NTRK23.64839501
4MAP3K93.44901438
5MARK13.42574416
6MAP3K42.72338089
7TNIK2.57727998
8MINK12.48484657
9PRKD32.30326586
10MAP2K72.28934888
11PAK62.23264340
12CASK1.93133714
13PKN11.88006177
14DAPK21.87294709
15LMTK21.86800825
16MAP3K121.84870523
17PHKG21.72954749
18PHKG11.72954749
19MAP2K41.71738117
20NTRK11.69321502
21MAPK131.69305978
22KSR21.68538291
23CAMKK11.68061725
24KSR11.66699451
25TYRO31.61458326
26CDK51.51270143
27STK381.49212248
28SIK21.30374728
29MAPK151.24518161
30UHMK11.22590540
31PRKCG1.16931028
32PRPF4B1.14852850
33SGK2231.14126245
34SGK4941.14126245
35FES1.10239613
36CDK191.08868067
37SGK21.07234452
38PLK21.03955376
39DYRK21.03725748
40NEK10.99519827
41PRKCH0.96931400
42PAK30.95729606
43DAPK10.93948692
44GRK50.92521373
45SGK30.92463040
46CDK180.91793805
47LATS20.91453900
48CDK150.91253330
49CAMK2A0.90896548
50CSNK1G20.87704708
51PNCK0.87354006
52STK110.86829706
53CDK140.83307280
54CAMK10.81589511
55MAP3K130.80687602
56PINK10.80090672
57CDK11A0.78525448
58ARAF0.77122496
59CAMK1G0.76920774
60NEK60.76513667
61ALK0.75035351
62RIPK40.74762087
63RET0.74445868
64MARK20.72781079
65FGFR20.72396140
66DYRK1A0.70751842
67CAMKK20.69572526
68MAPK120.69242335
69CDC42BPA0.66259328
70SGK10.65507468
71TAOK10.64776820
72PDGFRA0.64515399
73MAP3K20.63626324
74TNK20.61864234
75ICK0.61579387
76CAMK2B0.59669058
77FER0.58663213
78CDK30.57634398
79MAPKAPK50.57582936
80PDGFRB0.52357866
81RPS6KA30.52198538
82CSNK1G10.50153178
83OXSR10.49513688
84PRKCZ0.49227342
85ROCK10.48944744
86PRKCE0.48723695
87ROCK20.47706980
88PRKG10.47548989
89CSNK1D0.47393710
90ERBB20.47332687
91FYN0.47172774
92CAMK2G0.47034360
93MAPK100.46166932
94CAMK40.44058235
95RIPK10.43927478
96FGR0.43191906
97WNK30.42829685
98MUSK0.42293074
99RPS6KB10.41602084
100CSNK1G30.40380526
101MAP2K10.40321357
102SIK30.40316775
103RAF10.39987334
104PRKDC0.39905063
105DDR20.39350500
106CSNK1A10.38954135
107MAP3K70.38070782
108MAPK40.37701177
109MAP3K10.36228256
110BMX0.36193715
111CSNK1A1L0.35250412
112BRSK10.35024174
113PRKD10.34889863
114WNK10.34876074
115CAMK2D0.34762931
116PDPK10.34720002
117GSK3B0.32454105
118EPHB10.31287544
119CSNK1E0.27069509
120EPHA30.26892063
121PRKACA0.26589707
122PRKCA0.26044879
123MAPK80.25985560
124PIK3CA0.25819650

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.77159439
2Synaptic vesicle cycle_Homo sapiens_hsa047212.92491134
3GABAergic synapse_Homo sapiens_hsa047272.89085621
4Nitrogen metabolism_Homo sapiens_hsa009102.64728730
5Glutamatergic synapse_Homo sapiens_hsa047242.53303310
6Olfactory transduction_Homo sapiens_hsa047402.50147072
7* Circadian entrainment_Homo sapiens_hsa047132.46566979
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.46165727
9Morphine addiction_Homo sapiens_hsa050322.39533602
10Long-term potentiation_Homo sapiens_hsa047202.27268822
11Amphetamine addiction_Homo sapiens_hsa050312.12948797
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.12673026
13Salivary secretion_Homo sapiens_hsa049702.09534992
14Gastric acid secretion_Homo sapiens_hsa049711.94957186
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.92995154
16Dopaminergic synapse_Homo sapiens_hsa047281.90405704
17* Insulin secretion_Homo sapiens_hsa049111.89163448
18Cholinergic synapse_Homo sapiens_hsa047251.72082826
19Cocaine addiction_Homo sapiens_hsa050301.70466167
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64308244
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59967096
22Taste transduction_Homo sapiens_hsa047421.59710901
23Long-term depression_Homo sapiens_hsa047301.54550057
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53572411
25Calcium signaling pathway_Homo sapiens_hsa040201.51791587
26Serotonergic synapse_Homo sapiens_hsa047261.47457247
27Oxytocin signaling pathway_Homo sapiens_hsa049211.43850693
28* Renin secretion_Homo sapiens_hsa049241.41337779
29Gap junction_Homo sapiens_hsa045401.39894810
30Vitamin B6 metabolism_Homo sapiens_hsa007501.35284962
31GnRH signaling pathway_Homo sapiens_hsa049121.33879397
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32506505
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.30525825
34Axon guidance_Homo sapiens_hsa043601.26526365
35* cAMP signaling pathway_Homo sapiens_hsa040241.24588953
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17477282
37Dorso-ventral axis formation_Homo sapiens_hsa043201.14526345
38Melanogenesis_Homo sapiens_hsa049161.13253265
39Type II diabetes mellitus_Homo sapiens_hsa049301.06559491
40Estrogen signaling pathway_Homo sapiens_hsa049151.06413277
41Glioma_Homo sapiens_hsa052141.06183607
42* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04222795
43Collecting duct acid secretion_Homo sapiens_hsa049660.99618574
44ErbB signaling pathway_Homo sapiens_hsa040120.98452533
45Histidine metabolism_Homo sapiens_hsa003400.97091305
46Fatty acid biosynthesis_Homo sapiens_hsa000610.94031444
47beta-Alanine metabolism_Homo sapiens_hsa004100.92538274
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92500937
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91662906
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.90132891
51Cardiac muscle contraction_Homo sapiens_hsa042600.88942965
52Pancreatic secretion_Homo sapiens_hsa049720.85917728
53Bile secretion_Homo sapiens_hsa049760.84204114
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83385236
55Dilated cardiomyopathy_Homo sapiens_hsa054140.82960321
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81512511
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80828826
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.78747711
59Oocyte meiosis_Homo sapiens_hsa041140.77056494
60Thyroid hormone synthesis_Homo sapiens_hsa049180.76258093
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74456779
62Hippo signaling pathway_Homo sapiens_hsa043900.72964951
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72051210
64Notch signaling pathway_Homo sapiens_hsa043300.71061849
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70526226
66Choline metabolism in cancer_Homo sapiens_hsa052310.68926799
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66700064
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66478891
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65344258
70Vibrio cholerae infection_Homo sapiens_hsa051100.64297958
71MAPK signaling pathway_Homo sapiens_hsa040100.62155049
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60723644
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.60460102
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57992859
75Rap1 signaling pathway_Homo sapiens_hsa040150.56752358
76Ras signaling pathway_Homo sapiens_hsa040140.54728148
77Wnt signaling pathway_Homo sapiens_hsa043100.54688147
78Endometrial cancer_Homo sapiens_hsa052130.54033605
79Arginine and proline metabolism_Homo sapiens_hsa003300.52452820
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.51417502
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50684719
82Type I diabetes mellitus_Homo sapiens_hsa049400.50401682
83Prion diseases_Homo sapiens_hsa050200.50280612
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49832245
85Hedgehog signaling pathway_Homo sapiens_hsa043400.49788456
86Glucagon signaling pathway_Homo sapiens_hsa049220.48538839
87Circadian rhythm_Homo sapiens_hsa047100.47769354
88Colorectal cancer_Homo sapiens_hsa052100.47435939
89PPAR signaling pathway_Homo sapiens_hsa033200.47267181
90Tight junction_Homo sapiens_hsa045300.47221499
91Fatty acid metabolism_Homo sapiens_hsa012120.45891301
92Butanoate metabolism_Homo sapiens_hsa006500.45887318
93Ovarian steroidogenesis_Homo sapiens_hsa049130.44661558
94mTOR signaling pathway_Homo sapiens_hsa041500.43834628
95Alcoholism_Homo sapiens_hsa050340.43436992
96Renal cell carcinoma_Homo sapiens_hsa052110.42507582
97Arginine biosynthesis_Homo sapiens_hsa002200.41656686
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40612842
99Endocytosis_Homo sapiens_hsa041440.39523137
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39218759
101Phototransduction_Homo sapiens_hsa047440.38952433
102Insulin signaling pathway_Homo sapiens_hsa049100.38430952
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37875284
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36920093
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.36768979
106VEGF signaling pathway_Homo sapiens_hsa043700.36549734
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36202769
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36156310
109Basal cell carcinoma_Homo sapiens_hsa052170.36114156
110Non-small cell lung cancer_Homo sapiens_hsa052230.35308902
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34857960
112AMPK signaling pathway_Homo sapiens_hsa041520.34467315
113Inositol phosphate metabolism_Homo sapiens_hsa005620.34430152

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