ADD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.91257931
2locomotory exploration behavior (GO:0035641)4.90651623
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.52508659
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.20272611
5layer formation in cerebral cortex (GO:0021819)4.15696012
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.12674658
7regulation of synapse structural plasticity (GO:0051823)3.79925041
8synaptic vesicle exocytosis (GO:0016079)3.78295787
9synaptic vesicle docking involved in exocytosis (GO:0016081)3.71094718
10axon ensheathment in central nervous system (GO:0032291)3.70036903
11central nervous system myelination (GO:0022010)3.70036903
12glutamate secretion (GO:0014047)3.69793615
13dendritic spine morphogenesis (GO:0060997)3.66829227
14regulation of synaptic vesicle exocytosis (GO:2000300)3.65373976
15vocalization behavior (GO:0071625)3.62743629
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.59930278
17cytoskeletal anchoring at plasma membrane (GO:0007016)3.54171574
18sodium ion export (GO:0071436)3.51742638
19negative regulation of erythrocyte differentiation (GO:0045647)3.48769327
20exploration behavior (GO:0035640)3.46608850
21regulation of long-term neuronal synaptic plasticity (GO:0048169)3.34615168
22establishment of nucleus localization (GO:0040023)3.33861447
23regulation of neuronal synaptic plasticity (GO:0048168)3.32573567
24regulation of glutamate receptor signaling pathway (GO:1900449)3.29941460
25dendrite morphogenesis (GO:0048813)3.26082447
26protein localization to synapse (GO:0035418)3.17169141
27cellular potassium ion homeostasis (GO:0030007)3.15699106
28regulation of synaptic vesicle transport (GO:1902803)3.14978777
29regulation of ARF protein signal transduction (GO:0032012)3.13670506
30neuron recognition (GO:0008038)3.13260260
31activation of protein kinase A activity (GO:0034199)3.07803330
32ionotropic glutamate receptor signaling pathway (GO:0035235)3.04894270
33positive regulation of synapse maturation (GO:0090129)3.03181294
34neuromuscular process controlling balance (GO:0050885)3.02531500
35axonal fasciculation (GO:0007413)3.01875516
36neuron cell-cell adhesion (GO:0007158)2.98858283
37nerve growth factor signaling pathway (GO:0038180)2.98155772
38regulation of dendritic spine morphogenesis (GO:0061001)2.97419334
39neuronal ion channel clustering (GO:0045161)2.95249155
40lens fiber cell development (GO:0070307)2.94592641
41neuronal action potential propagation (GO:0019227)2.93145036
42positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.92610799
43transmission of nerve impulse (GO:0019226)2.91521760
44cell communication by electrical coupling (GO:0010644)2.88372279
45protein localization to endosome (GO:0036010)2.87731524
46neurotransmitter secretion (GO:0007269)2.83055858
47G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.81058675
48glycine transport (GO:0015816)2.80973845
49membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.78632154
50peptidyl-tyrosine autophosphorylation (GO:0038083)2.77209664
51L-amino acid import (GO:0043092)2.77142897
52positive regulation of membrane potential (GO:0045838)2.77138404
53cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.76819594
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.75189265
55negative regulation of axonogenesis (GO:0050771)2.74653480
56auditory behavior (GO:0031223)2.72692202
57long-term memory (GO:0007616)2.71951523
58cellular response to monoamine stimulus (GO:0071868)2.71235153
59cellular response to catecholamine stimulus (GO:0071870)2.71235153
60vesicle transport along microtubule (GO:0047496)2.70075231
61regulation of ARF GTPase activity (GO:0032312)2.69877072
62dendritic spine organization (GO:0097061)2.69228881
63cell migration in hindbrain (GO:0021535)2.67214836
64myelination (GO:0042552)2.66895620
65regulation of excitatory postsynaptic membrane potential (GO:0060079)2.66788537
66potassium ion import (GO:0010107)2.66390953
67synaptic transmission, glutamatergic (GO:0035249)2.66207237
68positive regulation of receptor recycling (GO:0001921)2.65800475
69regulation of synaptic plasticity (GO:0048167)2.65726124
70axon ensheathment (GO:0008366)2.65293719
71ensheathment of neurons (GO:0007272)2.65293719
72adherens junction assembly (GO:0034333)2.64460454
73proline transport (GO:0015824)2.63488654
74clathrin coat assembly (GO:0048268)2.63381125
75amino acid import (GO:0043090)2.62984074
76gamma-aminobutyric acid transport (GO:0015812)2.62435376
77cerebellar Purkinje cell differentiation (GO:0021702)2.60687774
78mannose metabolic process (GO:0006013)2.59372601
79positive regulation of Rap GTPase activity (GO:0032854)2.58830713
80stress fiber assembly (GO:0043149)2.58039044
81cortical actin cytoskeleton organization (GO:0030866)2.57816033
82regulation of dendritic spine development (GO:0060998)2.57802819
83regulation of early endosome to late endosome transport (GO:2000641)2.56054855
84positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.55817661
85negative regulation of oligodendrocyte differentiation (GO:0048715)2.54633798
86glutamate receptor signaling pathway (GO:0007215)2.54614026
87membrane hyperpolarization (GO:0060081)2.54259717
88positive regulation of dendritic spine development (GO:0060999)2.53826956
89response to auditory stimulus (GO:0010996)2.53117287
90cell-substrate adherens junction assembly (GO:0007045)2.53099256
91focal adhesion assembly (GO:0048041)2.53099256
92cellular response to epinephrine stimulus (GO:0071872)2.52962069
93organelle transport along microtubule (GO:0072384)2.52135523
94positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.51791679
95regulation of postsynaptic membrane potential (GO:0060078)2.51779142
96negative regulation of microtubule polymerization (GO:0031115)2.51614870
97regulation of voltage-gated calcium channel activity (GO:1901385)2.50763988
98protein targeting to plasma membrane (GO:0072661)2.50303493
99neurotransmitter-gated ion channel clustering (GO:0072578)2.49036520
100regulation of extracellular matrix disassembly (GO:0010715)2.46442063
101negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.46434652
102negative regulation of axon extension (GO:0030517)2.46126406
103regulation of dendrite morphogenesis (GO:0048814)2.45379713
104cerebellar granule cell differentiation (GO:0021707)2.45093137
105neuron-neuron synaptic transmission (GO:0007270)2.44586319
106synapse organization (GO:0050808)2.42656585
107prepulse inhibition (GO:0060134)2.41644763
108mating behavior (GO:0007617)2.41402998
109positive regulation of fibroblast migration (GO:0010763)2.40320475
110neuron projection morphogenesis (GO:0048812)2.39631037
111insulin-like growth factor receptor signaling pathway (GO:0048009)2.38645125
112dopamine receptor signaling pathway (GO:0007212)2.38405039
113central nervous system projection neuron axonogenesis (GO:0021952)2.37517878
114regulation of neurotransmitter secretion (GO:0046928)2.37187666
115regulation of dendrite development (GO:0050773)2.37172820
116cell-substrate junction assembly (GO:0007044)2.36179581
117positive regulation of dendrite development (GO:1900006)2.35946420
118semaphorin-plexin signaling pathway (GO:0071526)2.35890478
119positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.35170695
120potassium ion homeostasis (GO:0055075)2.34711116
121cortical cytoskeleton organization (GO:0030865)2.29753000
122regulation of Rap GTPase activity (GO:0032317)2.27726866
123positive regulation of blood vessel endothelial cell migration (GO:0043536)2.24640375
124response to monoamine (GO:0071867)2.19275525
125response to catecholamine (GO:0071869)2.19275525
126signal complex assembly (GO:0007172)2.18279368
127response to laminar fluid shear stress (GO:0034616)2.17185608
128regulation of NFAT protein import into nucleus (GO:0051532)2.14706016
129regulation of macrophage cytokine production (GO:0010935)2.11628230
130positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.10354622
131cellular response to prostaglandin stimulus (GO:0071379)2.09648038
132cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.08594133
133vascular endothelial growth factor signaling pathway (GO:0038084)2.08500145
134extracellular matrix assembly (GO:0085029)2.06285761
135cellular sodium ion homeostasis (GO:0006883)2.04616504
136actin filament depolymerization (GO:0030042)2.04300309
137positive regulation of macrophage cytokine production (GO:0060907)2.03915503
138negative regulation of Ras protein signal transduction (GO:0046580)2.03174113
139vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.02078575
140regulation of amyloid precursor protein catabolic process (GO:1902991)2.00980424
141negative regulation of fatty acid transport (GO:2000192)2.00466458
142* barbed-end actin filament capping (GO:0051016)1.99327483
143positive regulation of myotube differentiation (GO:0010831)1.99325682
144positive regulation of protein dephosphorylation (GO:0035307)1.97709502
145negative regulation of catenin import into nucleus (GO:0035414)1.97530478
146negative regulation of leukocyte mediated cytotoxicity (GO:0001911)1.96498145
147negative regulation of cell killing (GO:0031342)1.96498145
148planar cell polarity pathway involved in neural tube closure (GO:0090179)1.96166876
149activation of JUN kinase activity (GO:0007257)1.96076339
150hypotonic response (GO:0006971)1.95548206
151regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)1.95370633
152negative regulation of small GTPase mediated signal transduction (GO:0051058)1.94433091
153peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)1.94022476
154venous blood vessel morphogenesis (GO:0048845)1.93872514
155negative regulation of myotube differentiation (GO:0010832)1.93675027
156response to fluid shear stress (GO:0034405)1.93103762
157* actin filament capping (GO:0051693)1.90827261
158myelination in peripheral nervous system (GO:0022011)1.90719463
159peripheral nervous system axon ensheathment (GO:0032292)1.90719463
160negative regulation of cell size (GO:0045792)1.90036563
161protein retention in ER lumen (GO:0006621)1.89625444
162regulation of Ras protein signal transduction (GO:0046578)1.89563524

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.00302789
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.85394265
3DROSHA_22980978_ChIP-Seq_HELA_Human2.80022140
4EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74716520
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74716520
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.68224084
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64317444
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.58256127
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.55637223
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39093544
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.38615841
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32008077
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.28807755
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.28690829
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26672696
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.24225267
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.22219792
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20551251
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.18249601
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.14302969
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.11450210
22WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.08656740
23GBX2_23144817_ChIP-Seq_PC3_Human2.07431612
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03044548
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.00815711
26REST_21632747_ChIP-Seq_MESCs_Mouse1.87146582
27* KDM2B_26808549_Chip-Seq_K562_Human1.85292939
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.82860050
29EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.80404022
30* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.78356191
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.78191195
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.68697069
33AR_21572438_ChIP-Seq_LNCaP_Human1.67775770
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.65558013
35CLOCK_20551151_ChIP-Seq_293T_Human1.65517095
36DNAJC2_21179169_ChIP-ChIP_NT2_Human1.64758362
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61593493
38KDM2B_26808549_Chip-Seq_DND41_Human1.55187702
39* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.53567741
40WT1_25993318_ChIP-Seq_PODOCYTE_Human1.52254147
41VDR_21846776_ChIP-Seq_THP-1_Human1.48796412
42RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.48498587
43TP63_17297297_ChIP-ChIP_HaCaT_Human1.47469748
44GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45368392
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45083302
46TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.44119012
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43584669
48ZFP281_27345836_Chip-Seq_ESCs_Mouse1.43095995
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.41569496
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.41206414
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.39678959
52RACK7_27058665_Chip-Seq_MCF-7_Human1.38658992
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38138748
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.36277807
55MYC_22102868_ChIP-Seq_BL_Human1.35904944
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35123609
57DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.34240318
58* GATA1_19941827_ChIP-Seq_MEL_Mouse1.31986037
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30874762
60TBX20_22328084_ChIP-Seq_HEART_Mouse1.26468557
61TBX20_22080862_ChIP-Seq_HEART_Mouse1.26468557
62RING1B_27294783_Chip-Seq_NPCs_Mouse1.24542617
63NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23775934
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.23728687
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21864223
66UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20337904
67LXR_22292898_ChIP-Seq_THP-1_Human1.20254742
68* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19542452
69ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16694139
70SMC4_20622854_ChIP-Seq_HELA_Human1.15794383
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15512140
72GATA2_21666600_ChIP-Seq_HMVEC_Human1.15343517
73ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12368760
74AR_19668381_ChIP-Seq_PC3_Human1.12366260
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12304057
76EP300_21415370_ChIP-Seq_HL-1_Mouse1.12293266
77SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12101635
78OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.11898658
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11001473
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.10810784
81VDR_24763502_ChIP-Seq_THP-1_Human1.10708089
82GATA1_19941826_ChIP-Seq_K562_Human1.10505206
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10298653
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08962670
85ESR2_21235772_ChIP-Seq_MCF-7_Human1.08785425
86NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07405298
87SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06600311
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06600047
89* SOX2_21211035_ChIP-Seq_LN229_Gbm1.05994954
90STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.05862350
91* TET1_21490601_ChIP-Seq_MESCs_Mouse1.04382653
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04209627
93* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03707428
94CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01866896
95* TP53_23651856_ChIP-Seq_MEFs_Mouse1.01043376
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00482871
97SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99435664
98P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99293435
99KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99261224
100CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98381988
101SPI1_23127762_ChIP-Seq_K562_Human0.98120329
102TRIM28_21343339_ChIP-Seq_HEK293_Human0.97972948
103PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97588466
104SMAD_19615063_ChIP-ChIP_OVARY_Human0.97168936
105AHR_22903824_ChIP-Seq_MCF-7_Human0.96895390
106RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96766859
107CTCF_27219007_Chip-Seq_Bcells_Human0.96729687
108E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96320694
109KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96288848
110SA1_27219007_Chip-Seq_ERYTHROID_Human0.95696050
111P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95067174
112CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95039748
113* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.94435163
114TP53_20018659_ChIP-ChIP_R1E_Mouse0.93279132
115SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93109233
116NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92393302
117* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92275894
118STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91541759
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91056144
120SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90339993
121TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.89891251
122RXR_22108803_ChIP-Seq_LS180_Human0.89642893
123* SMAD4_21741376_ChIP-Seq_HESCs_Human0.89628019
124ISL1_27105846_Chip-Seq_CPCs_Mouse0.89449116
125ESR1_20079471_ChIP-ChIP_T-47D_Human0.89287087
126CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89029931
127ARNT_22903824_ChIP-Seq_MCF-7_Human0.88550421
128RUNX_20019798_ChIP-Seq_JUKART_Human0.88488204
129GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86764361
130SMAD3_21741376_ChIP-Seq_ESCs_Human0.86536136
131* SMAD4_21799915_ChIP-Seq_A2780_Human0.86185960
132ELK3_25401928_ChIP-Seq_HUVEC_Human0.85539936
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84234687
134CTBP2_25329375_ChIP-Seq_LNCAP_Human0.83155617
135TCF7_22412390_ChIP-Seq_EML_Mouse0.83110899
136CREB1_26743006_Chip-Seq_LNCaP_Human0.82851989
137TP53_16413492_ChIP-PET_HCT116_Human0.82329118
138SMAD3_21741376_ChIP-Seq_HESCs_Human0.81670970

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.14919017
2MP0003880_abnormal_central_pattern4.85571658
3MP0003705_abnormal_hypodermis_morpholog4.23037670
4MP0005423_abnormal_somatic_nervous3.39489632
5MP0009780_abnormal_chondrocyte_physiolo3.37901953
6MP0003635_abnormal_synaptic_transmissio3.34876220
7MP0004270_analgesia3.20988681
8MP0005409_darkened_coat_color2.60154145
9MP0002063_abnormal_learning/memory/cond2.57222974
10MP0003279_aneurysm2.45818891
11MP0002064_seizures2.44555514
12MP0009745_abnormal_behavioral_response2.44465151
13MP0000778_abnormal_nervous_system2.35724779
14MP0004858_abnormal_nervous_system2.16308822
15MP0002822_catalepsy2.15643836
16MP0003566_abnormal_cell_adhesion2.13844777
17MP0003329_amyloid_beta_deposits2.11079197
18MP0003300_gastrointestinal_ulcer2.10596673
19MP0008569_lethality_at_weaning2.05115542
20MP0001486_abnormal_startle_reflex2.00294817
21MP0002272_abnormal_nervous_system1.94616751
22MP0002734_abnormal_mechanical_nocicepti1.87543348
23MP0001968_abnormal_touch/_nociception1.86268015
24MP0002572_abnormal_emotion/affect_behav1.86205603
25MP0004811_abnormal_neuron_physiology1.83074456
26MP0009046_muscle_twitch1.82605044
27MP0005275_abnormal_skin_tensile1.81964188
28MP0000920_abnormal_myelination1.80253186
29MP0004885_abnormal_endolymph1.79616797
30MP0005623_abnormal_meninges_morphology1.74734657
31MP0000955_abnormal_spinal_cord1.72864697
32MP0001849_ear_inflammation1.71774941
33MP0008260_abnormal_autophagy1.70154558
34MP0010368_abnormal_lymphatic_system1.69884909
35MP0003172_abnormal_lysosome_physiology1.66488393
36MP0003303_peritoneal_inflammation1.60132655
37MP0004272_abnormal_basement_membrane1.54346855
38MP0005503_abnormal_tendon_morphology1.54225241
39MP0010030_abnormal_orbit_morphology1.52990495
40MP0002882_abnormal_neuron_morphology1.50189394
41MP0000751_myopathy1.49869830
42MP0003122_maternal_imprinting1.47511202
43MP0001299_abnormal_eye_distance/1.46899072
44MP0002733_abnormal_thermal_nociception1.46414425
45MP0002184_abnormal_innervation1.45831104
46MP0004924_abnormal_behavior1.45440776
47MP0005386_behavior/neurological_phenoty1.45440776
48MP0003634_abnormal_glial_cell1.44863399
49MP0000569_abnormal_digit_pigmentation1.43368017
50MP0001958_emphysema1.42509323
51MP0000566_synostosis1.42294240
52MP0000767_abnormal_smooth_muscle1.42254485
53MP0001440_abnormal_grooming_behavior1.40399349
54MP0001970_abnormal_pain_threshold1.39970712
55MP0008961_abnormal_basal_metabolism1.39088722
56MP0002089_abnormal_postnatal_growth/wei1.38720220
57MP0002909_abnormal_adrenal_gland1.36000851
58MP0003690_abnormal_glial_cell1.31784723
59MP0005257_abnormal_intraocular_pressure1.28351074
60MP0002067_abnormal_sensory_capabilities1.26940433
61MP0002557_abnormal_social/conspecific_i1.26871289
62MP0002735_abnormal_chemical_nociception1.25726423
63MP0002736_abnormal_nociception_after1.22813130
64MP0003828_pulmonary_edema1.20704427
65MP0002066_abnormal_motor_capabilities/c1.17953229
66MP0006138_congestive_heart_failure1.17442218
67MP0005076_abnormal_cell_differentiation1.17243670
68MP0003633_abnormal_nervous_system1.16442756
69* MP0002152_abnormal_brain_morphology1.13939686
70MP0005451_abnormal_body_composition1.11772679
71MP0002896_abnormal_bone_mineralization1.10842449
72MP0009384_cardiac_valve_regurgitation1.10624377
73MP0000759_abnormal_skeletal_muscle1.10147351
74MP0003191_abnormal_cellular_cholesterol1.09834020
75MP0003283_abnormal_digestive_organ1.09450014
76MP0005023_abnormal_wound_healing1.09253750
77MP0002133_abnormal_respiratory_system1.08614371
78MP0005388_respiratory_system_phenotype1.08614371
79MP0002877_abnormal_melanocyte_morpholog1.08181879
80MP0005058_abnormal_lysosome_morphology1.06281895
81MP0003631_nervous_system_phenotype1.03748512
82MP0002998_abnormal_bone_remodeling1.02587145
83MP0001348_abnormal_lacrimal_gland1.02408717
84MP0009278_abnormal_bone_marrow1.00906542
85MP0005666_abnormal_adipose_tissue1.00335073
86MP0004510_myositis0.98858007
87MP0001501_abnormal_sleep_pattern0.98438256
88MP0006276_abnormal_autonomic_nervous0.98230432
89MP0005645_abnormal_hypothalamus_physiol0.98149893
90MP0004036_abnormal_muscle_relaxation0.97681722
91MP0001529_abnormal_vocalization0.96476794
92MP0010630_abnormal_cardiac_muscle0.95065093
93MP0010234_abnormal_vibrissa_follicle0.94836912
94MP0003632_abnormal_nervous_system0.93973838
95MP0004134_abnormal_chest_morphology0.93540206
96MP0000003_abnormal_adipose_tissue0.93031225
97MP0001851_eye_inflammation0.92594071
98MP0000013_abnormal_adipose_tissue0.91583473
99MP0005375_adipose_tissue_phenotype0.91317767
100MP0002249_abnormal_larynx_morphology0.90289001
101MP0005646_abnormal_pituitary_gland0.90105170
102MP0002229_neurodegeneration0.89368381
103MP0000747_muscle_weakness0.89213566
104MP0005595_abnormal_vascular_smooth0.88554784
105MP0003436_decreased_susceptibility_to0.87163328
106MP0005167_abnormal_blood-brain_barrier0.86221166
107MP0000604_amyloidosis0.85138085
108MP0003045_fibrosis0.85095962
109MP0003183_abnormal_peptide_metabolism0.83746869
110MP0000749_muscle_degeneration0.83542652
111MP0001915_intracranial_hemorrhage0.82613572
112MP0003091_abnormal_cell_migration0.81806334
113MP0000534_abnormal_ureter_morphology0.81650125
114* MP0003861_abnormal_nervous_system0.81224583
115MP0001879_abnormal_lymphatic_vessel0.80346679
116MP0002108_abnormal_muscle_morphology0.79525713
117MP0003075_altered_response_to0.78767627
118MP0004233_abnormal_muscle_weight0.78723596
119MP0001177_atelectasis0.78612665
120MP0001502_abnormal_circadian_rhythm0.78282402
121MP0003137_abnormal_impulse_conducting0.78077868
122MP0001984_abnormal_olfaction0.76731392
123MP0002234_abnormal_pharynx_morphology0.75862911
124MP0002752_abnormal_somatic_nervous0.75571535
125MP0004085_abnormal_heartbeat0.74999754
126MP0003115_abnormal_respiratory_system0.74839848
127MP0002971_abnormal_brown_adipose0.74312923
128MP0004084_abnormal_cardiac_muscle0.73886994
129MP0001943_abnormal_respiration0.73786925
130MP0004145_abnormal_muscle_electrophysio0.72445924
131MP0004947_skin_inflammation0.71207043
132MP0002090_abnormal_vision0.71071841
133MP0004130_abnormal_muscle_cell0.70497891
134MP0000537_abnormal_urethra_morphology0.70196931
135MP0002069_abnormal_eating/drinking_beha0.69646290
136MP0005508_abnormal_skeleton_morphology0.68646504
137MP0008874_decreased_physiological_sensi0.68471692
138MP0004742_abnormal_vestibular_system0.68185592
139MP0005551_abnormal_eye_electrophysiolog0.67668482
140MP0002128_abnormal_blood_circulation0.67582510
141MP0005464_abnormal_platelet_physiology0.66215328
142MP0001614_abnormal_blood_vessel0.66108187
143MP0009840_abnormal_foam_cell0.66035849
144MP0000249_abnormal_blood_vessel0.66035512
145MP0001905_abnormal_dopamine_level0.65413683
146MP0003879_abnormal_hair_cell0.65412616
147MP0004185_abnormal_adipocyte_glucose0.65320520
148MP0008438_abnormal_cutaneous_collagen0.64675537
149MP0000428_abnormal_craniofacial_morphol0.63758726
150MP0003787_abnormal_imprinting0.63346406
151MP0000733_abnormal_muscle_development0.61023351
152MP0003385_abnormal_body_wall0.59709037
153MP0004087_abnormal_muscle_fiber0.59470639

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.84745295
2Protrusio acetabuli (HP:0003179)3.80186747
3Megalencephaly (HP:0001355)3.61238781
4Supranuclear gaze palsy (HP:0000605)3.57719027
5Focal seizures (HP:0007359)3.51062288
6Obstructive sleep apnea (HP:0002870)3.43534025
7Focal motor seizures (HP:0011153)3.39716224
8Ankle clonus (HP:0011448)3.39353254
9Action tremor (HP:0002345)3.26003796
10Aplasia involving bones of the extremities (HP:0009825)3.15127474
11Aplasia involving bones of the upper limbs (HP:0009823)3.15127474
12Aplasia of the phalanges of the hand (HP:0009802)3.15127474
13Premature rupture of membranes (HP:0001788)3.02236752
14Insomnia (HP:0100785)2.97691846
15Visual hallucinations (HP:0002367)2.97502355
16Aortic aneurysm (HP:0004942)2.90556851
17Neurofibrillary tangles (HP:0002185)2.87523858
18Cerebral inclusion bodies (HP:0100314)2.72920870
19Insidious onset (HP:0003587)2.70312173
20Termporal pattern (HP:0011008)2.70312173
21Urinary urgency (HP:0000012)2.65868629
22Aortic dissection (HP:0002647)2.64803561
23Depression (HP:0000716)2.58566310
24Spastic gait (HP:0002064)2.55638572
25Atonic seizures (HP:0010819)2.50750145
26Dysmetria (HP:0001310)2.48348847
27Epileptic encephalopathy (HP:0200134)2.46172954
28Urinary bladder sphincter dysfunction (HP:0002839)2.45678433
29Abnormality of skeletal muscle fiber size (HP:0012084)2.44331445
30Hyperacusis (HP:0010780)2.42541021
31Type 1 muscle fiber predominance (HP:0003803)2.41521566
32Intention tremor (HP:0002080)2.41273218
33Alacrima (HP:0000522)2.39256508
34Pointed chin (HP:0000307)2.39062380
35Broad metatarsal (HP:0001783)2.35254042
36Abnormality of the corticospinal tract (HP:0002492)2.34682912
37Peritonitis (HP:0002586)2.32943938
38Dilatation of the ascending aorta (HP:0005111)2.32536964
39Macroorchidism (HP:0000053)2.32396460
40Lower limb muscle weakness (HP:0007340)2.32333690
41Progressive cerebellar ataxia (HP:0002073)2.31075619
42Papilledema (HP:0001085)2.30778307
43Mitral regurgitation (HP:0001653)2.30286877
44Increased connective tissue (HP:0009025)2.25646462
45Aneurysm (HP:0002617)2.24453365
46Impaired vibration sensation in the lower limbs (HP:0002166)2.23551427
47Dysdiadochokinesis (HP:0002075)2.23382607
48Shallow orbits (HP:0000586)2.23367484
49Coronal craniosynostosis (HP:0004440)2.23127742
50Abnormal eating behavior (HP:0100738)2.22840808
51Torticollis (HP:0000473)2.21924161
52Neonatal short-limb short stature (HP:0008921)2.21501968
53Arterial tortuosity (HP:0005116)2.21335283
54Truncal ataxia (HP:0002078)2.20369725
55Mitral valve prolapse (HP:0001634)2.18542870
56Spinal canal stenosis (HP:0003416)2.17552421
57Spinal rigidity (HP:0003306)2.16318351
58Distal lower limb amyotrophy (HP:0008944)2.15832740
59Wormian bones (HP:0002645)2.15631989
60Overriding aorta (HP:0002623)2.14166544
61Broad face (HP:0000283)2.12545881
62Hyporeflexia of lower limbs (HP:0002600)2.12258800
63Mutism (HP:0002300)2.11371358
64Thickened helices (HP:0000391)2.09908382
65Atrophic scars (HP:0001075)2.09817058
66Postural instability (HP:0002172)2.09334798
67Neoplasm of the heart (HP:0100544)2.07018955
68Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.07018298
69Degeneration of the lateral corticospinal tracts (HP:0002314)2.07018298
70Hemiplegia (HP:0002301)2.06784479
71Centrally nucleated skeletal muscle fibers (HP:0003687)2.06390803
72Genu recurvatum (HP:0002816)2.06357693
73Abnormality of binocular vision (HP:0011514)2.05088160
74Diplopia (HP:0000651)2.05088160
75Aqueductal stenosis (HP:0002410)2.03420112
76Scanning speech (HP:0002168)2.01908802
77Vascular tortuosity (HP:0004948)2.01891089
78Annular pancreas (HP:0001734)2.00895376
79Cervical subluxation (HP:0003308)1.99024821
80Impaired social interactions (HP:0000735)1.96835346
81Abnormal social behavior (HP:0012433)1.96835346
82Onion bulb formation (HP:0003383)1.95837143
83Poor eye contact (HP:0000817)1.95389729
84Overgrowth (HP:0001548)1.94943765
85Disproportionate tall stature (HP:0001519)1.90418308
86Fragile skin (HP:0001030)1.90381969
87Ankyloglossia (HP:0010296)1.89262412
88Cellulitis (HP:0100658)1.89146141
89Arnold-Chiari malformation (HP:0002308)1.89118417
90Rapidly progressive (HP:0003678)1.88640579
91Turricephaly (HP:0000262)1.88344491
92Amyotrophic lateral sclerosis (HP:0007354)1.88130260
93Abnormality of the lower motor neuron (HP:0002366)1.87588871
94Hammertoe (HP:0001765)1.87154150
95Heterotopia (HP:0002282)1.86708281
96Cerebral aneurysm (HP:0004944)1.86616257
97Distal lower limb muscle weakness (HP:0009053)1.86251900
98Genetic anticipation (HP:0003743)1.85921789
99Mildly elevated creatine phosphokinase (HP:0008180)1.85286140
100Muscle fiber splitting (HP:0003555)1.84970068
101Stereotypic behavior (HP:0000733)1.84350573
102Akinesia (HP:0002304)1.84177570
103Broad-based gait (HP:0002136)1.84131844
104Bronchomalacia (HP:0002780)1.83930245
105Increased variability in muscle fiber diameter (HP:0003557)1.83175805
106Elfin facies (HP:0004428)1.83136550
107Hypoplasia of the iris (HP:0007676)1.82615731
108Distal upper limb amyotrophy (HP:0007149)1.82584939
109Upper limb amyotrophy (HP:0009129)1.82584939
110Lower limb amyotrophy (HP:0007210)1.81985007
111Visceral angiomatosis (HP:0100761)1.81274914
112Hyperextensible skin (HP:0000974)1.81033027
113Exercise-induced myalgia (HP:0003738)1.81032771
114Anxiety (HP:0000739)1.81010901
115Focal dystonia (HP:0004373)1.80994009
116Hypoventilation (HP:0002791)1.80959173
117Clonus (HP:0002169)1.80906692
118Ventricular fibrillation (HP:0001663)1.80794041
119Decreased lacrimation (HP:0000633)1.80688624
120Apathy (HP:0000741)1.80553583
121Generalized tonic-clonic seizures (HP:0002069)1.77685057
122Ulnar bowing (HP:0003031)1.77368092
123Joint laxity (HP:0001388)1.77270876
124Vertebral arch anomaly (HP:0008438)1.77196441
125Bladder diverticulum (HP:0000015)1.76849714
126Drooling (HP:0002307)1.75244080
127Excessive salivation (HP:0003781)1.75244080
128Hallux valgus (HP:0001822)1.74994999
129Peripheral hypomyelination (HP:0007182)1.74781362
130Asymmetric septal hypertrophy (HP:0001670)1.73869451
131Difficulty running (HP:0009046)1.73765170
132Blue sclerae (HP:0000592)1.72778416
133Abnormality of oral frenula (HP:0000190)1.72507094
134Absence seizures (HP:0002121)1.72341600
135Deviation of the hallux (HP:0010051)1.72051882
136Diminished motivation (HP:0000745)1.70951442
137Lymphangioma (HP:0100764)1.70644488
138Dysmetric saccades (HP:0000641)1.70103516
139Amblyopia (HP:0000646)1.70053116
140Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.70023174
141Hypercortisolism (HP:0001578)1.69130460
142Infantile muscular hypotonia (HP:0008947)1.69063326
143Polycythemia (HP:0001901)1.68726882
144Abnormality of the fingertips (HP:0001211)1.67638968
145Foot dorsiflexor weakness (HP:0009027)1.67492226
146Thin bony cortex (HP:0002753)1.67267504
147Syringomyelia (HP:0003396)1.65848129
148Spinal cord lesions (HP:0100561)1.65848129
149Wide anterior fontanel (HP:0000260)1.64402582
150Spondylolisthesis (HP:0003302)1.62717833
151Ankle contracture (HP:0006466)1.62461293
152Mild short stature (HP:0003502)1.60906995
153Bowel diverticulosis (HP:0005222)1.60519270
154Decreased motor nerve conduction velocity (HP:0003431)1.60323493
155Hand muscle atrophy (HP:0009130)1.59332277
156Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.58680405
157Thin ribs (HP:0000883)1.58382292
158Emphysema (HP:0002097)1.57750009
159Vertebral compression fractures (HP:0002953)1.56534023
160Neuronal loss in central nervous system (HP:0002529)1.56357992
161Biconcave vertebral bodies (HP:0004586)1.54534856
162Osteolytic defects of the phalanges of the hand (HP:0009771)1.54203084
163Osteolytic defects of the hand bones (HP:0009699)1.54203084
164Slender build (HP:0001533)1.53867203
165Slow saccadic eye movements (HP:0000514)1.53191006
166Difficulty climbing stairs (HP:0003551)1.51717488
167Abnormality of the foot musculature (HP:0001436)1.51007827
168Dislocated radial head (HP:0003083)1.49854404

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.35325444
2EPHA43.14825785
3MARK12.71730216
4PRPF4B2.56914411
5NTRK32.55074484
6PAK62.53612842
7MINK12.26014326
8ERN12.18024637
9TYRO32.14602626
10KSR22.12500052
11PRKD32.10382371
12NTRK11.98727527
13ICK1.98524946
14TRIB31.96575675
15UHMK11.89020646
16DAPK21.83832072
17NTRK21.77286704
18CAMKK11.76459191
19FGFR41.67552137
20KSR11.58757191
21CDK121.56826923
22CDK51.53064660
23FGFR21.51823869
24MAP3K41.51686654
25SIK11.50594538
26LMTK21.50337936
27CDK191.39728512
28TNIK1.39210383
29RIPK11.36146807
30SIK21.36120442
31PRKCH1.30582529
32PRKD21.30225851
33FGFR31.29287506
34STK391.28450585
35PDGFRA1.27480903
36OXSR11.23693429
37SMG11.22948607
38RET1.22078861
39DMPK1.20546290
40PAK31.19324075
41PHKG11.17894749
42PHKG21.17894749
43TAOK11.13010020
44PKN21.11426562
45SGK2231.09115324
46SGK4941.09115324
47CDK141.06719697
48CDK151.05220764
49RPS6KA21.04814458
50CDK181.04600798
51FGFR11.02475642
52EPHB10.99920839
53MAP2K30.98767590
54ALK0.98016045
55MAP3K70.97645542
56MAPK120.97313591
57MAP3K20.96629757
58MAP3K130.96455844
59JAK10.96103246
60MARK20.95717497
61WNK10.94097738
62FES0.92545053
63CDK11A0.91166879
64DDR20.88794072
65MAPK130.88001516
66STK110.86786668
67MAP3K10.85456951
68CSNK1G20.84488939
69PTK2B0.84420418
70MAP3K100.84210762
71SGK20.83831931
72CAMK1G0.83518179
73MTOR0.82247990
74STK380.82207145
75SCYL20.79196884
76FYN0.78596791
77ZAP700.77460691
78MOS0.76146355
79EEF2K0.74656204
80TESK10.74217091
81NEK90.72707131
82TTN0.71895722
83PAK20.71860506
84MAP3K60.71733139
85LIMK10.70962167
86PDPK10.70161560
87PDGFRB0.70052443
88SGK30.70036857
89* ROCK20.69153836
90TYK20.68205995
91PDK10.67999506
92BCR0.65537405
93PTK20.65513886
94EPHB20.64984705
95MAP2K40.64433692
96MAPK70.63226416
97SGK10.63082195
98RIPK40.62565014
99CSNK1A1L0.61531636
100BMX0.61491628
101HIPK20.61170246
102CDC42BPA0.59343639
103LATS20.58220640
104RPS6KL10.56634141
105RPS6KC10.56634141
106DYRK1B0.56124962
107* MAPK100.55821375
108JAK20.55810932
109TNK20.55575936
110MAP4K10.54909071
111CAMK10.54729828
112DAPK10.54298263
113* ROCK10.53878413
114PTK60.53864401
115PRKD10.52802970
116LRRK20.52395519
117PRKCG0.50719656
118CAMKK20.49704793
119CSNK1G30.49433603
120RAF10.49417663
121MYLK0.48325753
122CAMK40.47144313
123FER0.45721258
124CAMK2A0.45533883
125HCK0.45484578
126MAP3K110.45142807
127BLK0.45095794
128CAMK2B0.45075446
129CSK0.44964748
130MAP2K70.44321950
131SRC0.44237482
132ARAF0.43131730
133DYRK1A0.42596780
134MAP3K30.42397017
135CAMK1D0.42195608
136TAOK20.41997995
137FGR0.41722958
138WNK40.41438266
139PKN10.40939848

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.23681485
2Synaptic vesicle cycle_Homo sapiens_hsa047212.11542130
3Circadian entrainment_Homo sapiens_hsa047132.00578125
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.93599641
5Glutamatergic synapse_Homo sapiens_hsa047241.92774648
6Long-term potentiation_Homo sapiens_hsa047201.88454142
7GABAergic synapse_Homo sapiens_hsa047271.84538904
8Morphine addiction_Homo sapiens_hsa050321.79800276
9Gastric acid secretion_Homo sapiens_hsa049711.73106743
10Dopaminergic synapse_Homo sapiens_hsa047281.72780596
11Axon guidance_Homo sapiens_hsa043601.71010548
12Salivary secretion_Homo sapiens_hsa049701.70642518
13Cholinergic synapse_Homo sapiens_hsa047251.69890300
14Nicotine addiction_Homo sapiens_hsa050331.69088816
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.66413195
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62590560
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53281996
18Amphetamine addiction_Homo sapiens_hsa050311.52134882
19Oxytocin signaling pathway_Homo sapiens_hsa049211.48773362
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47892471
21Gap junction_Homo sapiens_hsa045401.44718418
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44179052
23Dorso-ventral axis formation_Homo sapiens_hsa043201.41058594
24Renin secretion_Homo sapiens_hsa049241.39213877
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37101147
26Glioma_Homo sapiens_hsa052141.35874638
27Insulin secretion_Homo sapiens_hsa049111.33261583
28Cocaine addiction_Homo sapiens_hsa050301.29024957
29Long-term depression_Homo sapiens_hsa047301.28964646
30GnRH signaling pathway_Homo sapiens_hsa049121.28746385
31Phospholipase D signaling pathway_Homo sapiens_hsa040721.22837604
32Acute myeloid leukemia_Homo sapiens_hsa052211.21381687
33Prion diseases_Homo sapiens_hsa050201.19011104
34Endocytosis_Homo sapiens_hsa041441.15586551
35Estrogen signaling pathway_Homo sapiens_hsa049151.15176308
36ErbB signaling pathway_Homo sapiens_hsa040121.14092741
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12333364
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11778817
39Dilated cardiomyopathy_Homo sapiens_hsa054141.11494748
40cAMP signaling pathway_Homo sapiens_hsa040241.10985348
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.10562734
42Melanogenesis_Homo sapiens_hsa049161.08180651
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07402207
44Serotonergic synapse_Homo sapiens_hsa047261.05341980
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05327128
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.05198272
47Calcium signaling pathway_Homo sapiens_hsa040201.04791488
48Type II diabetes mellitus_Homo sapiens_hsa049301.04315135
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04268600
50VEGF signaling pathway_Homo sapiens_hsa043701.04171302
51Renal cell carcinoma_Homo sapiens_hsa052111.04057097
52cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02661475
53Amoebiasis_Homo sapiens_hsa051461.02530692
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00770724
55Choline metabolism in cancer_Homo sapiens_hsa052310.95425222
56Adherens junction_Homo sapiens_hsa045200.94937114
57Prolactin signaling pathway_Homo sapiens_hsa049170.93580147
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.92774274
59Phototransduction_Homo sapiens_hsa047440.90892633
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90295079
61Rap1 signaling pathway_Homo sapiens_hsa040150.89684814
62Endometrial cancer_Homo sapiens_hsa052130.89666178
63Nitrogen metabolism_Homo sapiens_hsa009100.89652821
64Non-small cell lung cancer_Homo sapiens_hsa052230.88775174
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87506458
66Focal adhesion_Homo sapiens_hsa045100.87020629
67Oocyte meiosis_Homo sapiens_hsa041140.86980016
68Osteoclast differentiation_Homo sapiens_hsa043800.86915547
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.85940472
70MAPK signaling pathway_Homo sapiens_hsa040100.84980746
71Chronic myeloid leukemia_Homo sapiens_hsa052200.83363023
72Taste transduction_Homo sapiens_hsa047420.83300029
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83175199
74mTOR signaling pathway_Homo sapiens_hsa041500.83003581
75Platelet activation_Homo sapiens_hsa046110.82802241
76Proteoglycans in cancer_Homo sapiens_hsa052050.81747903
77Ras signaling pathway_Homo sapiens_hsa040140.80908467
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80115607
79Tight junction_Homo sapiens_hsa045300.76824109
80Colorectal cancer_Homo sapiens_hsa052100.76527478
81Other glycan degradation_Homo sapiens_hsa005110.76054603
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74160850
83Hippo signaling pathway_Homo sapiens_hsa043900.73234663
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73231246
85Wnt signaling pathway_Homo sapiens_hsa043100.73177604
86Chemokine signaling pathway_Homo sapiens_hsa040620.72125770
87Hedgehog signaling pathway_Homo sapiens_hsa043400.71974117
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71961563
89AMPK signaling pathway_Homo sapiens_hsa041520.71107635
90Notch signaling pathway_Homo sapiens_hsa043300.71027778
91Pancreatic secretion_Homo sapiens_hsa049720.70804383
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.70282890
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70003895
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69277142
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.68401030
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68293531
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68269008
98Prostate cancer_Homo sapiens_hsa052150.67440335
99Thyroid cancer_Homo sapiens_hsa052160.67252538
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66924898
101Thyroid hormone synthesis_Homo sapiens_hsa049180.65965034
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65269156
103Pancreatic cancer_Homo sapiens_hsa052120.63682951
104Protein digestion and absorption_Homo sapiens_hsa049740.63532571
105Basal cell carcinoma_Homo sapiens_hsa052170.62532435
106MicroRNAs in cancer_Homo sapiens_hsa052060.62470351
107Bile secretion_Homo sapiens_hsa049760.62263741
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61523954
109T cell receptor signaling pathway_Homo sapiens_hsa046600.61229610
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60893862
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57782023
112Alcoholism_Homo sapiens_hsa050340.57332313
113B cell receptor signaling pathway_Homo sapiens_hsa046620.55607803
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55210448
115Insulin signaling pathway_Homo sapiens_hsa049100.54990070
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.54686280
117ECM-receptor interaction_Homo sapiens_hsa045120.54084020
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.53286360
119Inositol phosphate metabolism_Homo sapiens_hsa005620.52740800

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