ADD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.07451101
2sodium ion export (GO:0071436)4.36917480
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.33386819
4negative regulation of cell killing (GO:0031342)4.33386819
5activated T cell proliferation (GO:0050798)3.96906523
6phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.93236878
7cellular potassium ion homeostasis (GO:0030007)3.80869788
8L-amino acid import (GO:0043092)3.79999589
9potassium ion import (GO:0010107)3.73369601
10locomotory exploration behavior (GO:0035641)3.61176296
11negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.51407531
12positive regulation of granulocyte differentiation (GO:0030854)3.43549261
13regulation of gamma-delta T cell activation (GO:0046643)3.39018157
14negative T cell selection (GO:0043383)3.33904436
15negative thymic T cell selection (GO:0045060)3.33568387
16axon ensheathment in central nervous system (GO:0032291)3.30894424
17central nervous system myelination (GO:0022010)3.30894424
18positive regulation of Rap GTPase activity (GO:0032854)3.16587755
19neutrophil activation involved in immune response (GO:0002283)3.07880157
20amino acid import (GO:0043090)3.07757934
21peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.07019427
22negative regulation of lymphocyte mediated immunity (GO:0002707)3.02407112
23regulation of tolerance induction (GO:0002643)2.99719695
24positive thymic T cell selection (GO:0045059)2.97543908
25negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.94036999
26regulation of Rap GTPase activity (GO:0032317)2.93993590
27thymic T cell selection (GO:0045061)2.93043543
28cytoskeletal anchoring at plasma membrane (GO:0007016)2.92100643
29myelination in peripheral nervous system (GO:0022011)2.89590924
30peripheral nervous system axon ensheathment (GO:0032292)2.89590924
31regulation of B cell receptor signaling pathway (GO:0050855)2.88783307
32membrane repolarization (GO:0086009)2.87477556
33histone H3-K36 demethylation (GO:0070544)2.87182413
34synaptic vesicle maturation (GO:0016188)2.85871576
35protein localization to endosome (GO:0036010)2.85398626
36cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.85074467
37negative regulation of T cell mediated immunity (GO:0002710)2.84431067
38regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.83710558
39negative regulation of T-helper cell differentiation (GO:0045623)2.83514334
40negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.83514334
41positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.81853174
42nerve growth factor signaling pathway (GO:0038180)2.80666536
43cellular sodium ion homeostasis (GO:0006883)2.76976600
44regulation of beta-amyloid formation (GO:1902003)2.76416812
45regulation of ARF protein signal transduction (GO:0032012)2.75280275
46cellular extravasation (GO:0045123)2.74833576
47positive T cell selection (GO:0043368)2.74647964
48cell communication by electrical coupling (GO:0010644)2.72141339
49regulation of platelet aggregation (GO:0090330)2.70252571
50regulation of transforming growth factor beta2 production (GO:0032909)2.69327928
51regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.68156251
52phospholipid scrambling (GO:0017121)2.66965141
53positive regulation of gamma-delta T cell activation (GO:0046645)2.66943594
54T cell selection (GO:0045058)2.66481415
55regulation of amyloid precursor protein catabolic process (GO:1902991)2.65209167
56regulation of extracellular matrix disassembly (GO:0010715)2.64986082
57antigen processing and presentation via MHC class Ib (GO:0002475)2.64896145
58regulation of B cell differentiation (GO:0045577)2.64457780
59regulation of alpha-beta T cell proliferation (GO:0046640)2.64259737
60positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.62777887
61negative regulation of leukocyte mediated immunity (GO:0002704)2.62381585
62regulation of regulatory T cell differentiation (GO:0045589)2.62075651
63potassium ion homeostasis (GO:0055075)2.61643474
64membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.59836727
65positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.59635079
66positive regulation of potassium ion transmembrane transport (GO:1901381)2.55935615
67lipid translocation (GO:0034204)2.55594106
68phospholipid translocation (GO:0045332)2.55594106
69layer formation in cerebral cortex (GO:0021819)2.54419449
70myelination (GO:0042552)2.53943555
71regulation of T cell tolerance induction (GO:0002664)2.53287802
72ensheathment of neurons (GO:0007272)2.52754101
73axon ensheathment (GO:0008366)2.52754101
74protein targeting to Golgi (GO:0000042)2.52556246
75cortical actin cytoskeleton organization (GO:0030866)2.52541407
76response to laminar fluid shear stress (GO:0034616)2.51088254
77negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.50917722
78leukocyte aggregation (GO:0070486)2.49810529
79positive regulation by symbiont of host defense response (GO:0052509)2.49137949
80modulation by symbiont of host defense response (GO:0052031)2.49137949
81modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.49137949
82modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.49137949
83positive regulation by organism of defense response of other organism involved in symbiotic interact2.49137949
84modulation by symbiont of host immune response (GO:0052553)2.49137949
85myelin maintenance (GO:0043217)2.47489917
86T cell migration (GO:0072678)2.46671468
87detection of other organism (GO:0098543)2.46339917
88positive regulation of potassium ion transport (GO:0043268)2.46115173
89T cell receptor signaling pathway (GO:0050852)2.45993602
90antigen receptor-mediated signaling pathway (GO:0050851)2.45757344
91peptidyl-tyrosine autophosphorylation (GO:0038083)2.45712844
92cellular response to interleukin-15 (GO:0071350)2.45550331
93neutrophil activation (GO:0042119)2.44448107
94membrane repolarization during action potential (GO:0086011)2.44238637
95regulation of protein glycosylation (GO:0060049)2.43950519
96microglial cell activation (GO:0001774)2.43907965
97signal complex assembly (GO:0007172)2.43887271
98relaxation of cardiac muscle (GO:0055119)2.43798286
99response to interleukin-15 (GO:0070672)2.43771247
100histone H3-K9 demethylation (GO:0033169)2.42667622
101leukocyte migration involved in inflammatory response (GO:0002523)2.42402496
102positive regulation of tolerance induction (GO:0002645)2.42360627
103B cell receptor signaling pathway (GO:0050853)2.41683286
104negative regulation of glycoprotein biosynthetic process (GO:0010561)2.41589044
105regulation of macrophage cytokine production (GO:0010935)2.41401804
106establishment of protein localization to Golgi (GO:0072600)2.38396890
107regulation of gamma-delta T cell differentiation (GO:0045586)2.38305548
108fibril organization (GO:0097435)2.37757638
109dendritic cell migration (GO:0036336)2.37486790
110interleukin-6-mediated signaling pathway (GO:0070102)2.37189233
111pathway-restricted SMAD protein phosphorylation (GO:0060389)2.36242438
112positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.34669920
113negative regulation of cardiac muscle tissue growth (GO:0055022)2.34392742
114negative regulation of heart growth (GO:0061117)2.34392742
115antigen processing and presentation of endogenous antigen (GO:0019883)2.33930372
116mast cell activation (GO:0045576)2.33039332
117stress fiber assembly (GO:0043149)2.32890168
118antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.32002527
119antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.32002527
120cortical cytoskeleton organization (GO:0030865)2.31786377
121positive regulation of cellular amide metabolic process (GO:0034250)2.31171943
122regulation of voltage-gated calcium channel activity (GO:1901385)2.30128972
123regulation of cardiac muscle cell contraction (GO:0086004)2.28980786
124regulation of ARF GTPase activity (GO:0032312)2.27618078
125radial glial cell differentiation (GO:0060019)2.26726662
126blood vessel maturation (GO:0001955)2.26504054
127T cell costimulation (GO:0031295)2.25900279
128heterotypic cell-cell adhesion (GO:0034113)2.25636830
129negative regulation of type 2 immune response (GO:0002829)2.25480292
130photoreceptor cell differentiation (GO:0046530)2.25259214
131eye photoreceptor cell differentiation (GO:0001754)2.25259214
132negative regulation of potassium ion transmembrane transport (GO:1901380)2.23720917
133positive regulation of fibroblast migration (GO:0010763)2.23292618
134positive regulation of B cell differentiation (GO:0045579)2.23236583
135phagocytosis, engulfment (GO:0006911)2.22098924
136tolerance induction (GO:0002507)2.21309636
137dendritic cell chemotaxis (GO:0002407)2.21305780
138positive regulation of histone deacetylation (GO:0031065)2.21299070
139hypotonic response (GO:0006971)2.20893176
140positive regulation of alpha-beta T cell proliferation (GO:0046641)2.20730755
141negative regulation of adaptive immune response (GO:0002820)2.20723871
142positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.20140021
143positive regulation of humoral immune response (GO:0002922)2.20059569
144lymphocyte costimulation (GO:0031294)2.19548253
145extracellular fibril organization (GO:0043206)2.18992011
146retrograde transport, vesicle recycling within Golgi (GO:0000301)2.18991262
147establishment of nucleus localization (GO:0040023)2.16258992
148negative regulation of protein localization to cell surface (GO:2000009)2.15532047
149negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.14843161
150natural killer cell differentiation (GO:0001779)2.14695879
151centrosome localization (GO:0051642)2.14568679
152regulation of actin filament-based movement (GO:1903115)2.13270717
153long-term synaptic potentiation (GO:0060291)2.09846908
154membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.09795574
155mannose metabolic process (GO:0006013)2.08845595
156G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.08339738
157exploration behavior (GO:0035640)2.07652137
158regulation of potassium ion transmembrane transport (GO:1901379)2.07033000
159positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.06979719
160adenosine receptor signaling pathway (GO:0001973)2.06344124
161negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.05843475
162positive regulation of lamellipodium assembly (GO:0010592)2.04640620
163regulation of isotype switching to IgG isotypes (GO:0048302)2.02355542
164cellular response to nerve growth factor stimulus (GO:1990090)2.02137763
165response to nerve growth factor (GO:1990089)2.02137763
166positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.01904778

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.72614259
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.19554690
3EZH2_22144423_ChIP-Seq_EOC_Human2.73589221
4* RUNX_20019798_ChIP-Seq_JUKART_Human2.41714267
5DROSHA_22980978_ChIP-Seq_HELA_Human2.29570170
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.20273812
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.19119732
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.16687974
9IKZF1_21737484_ChIP-ChIP_HCT116_Human2.11167109
10AR_21572438_ChIP-Seq_LNCaP_Human2.02312776
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.92722771
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.92335292
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.83402509
14SMAD_19615063_ChIP-ChIP_OVARY_Human1.81082729
15EZH2_18974828_ChIP-Seq_MESCs_Mouse1.79110494
16RNF2_18974828_ChIP-Seq_MESCs_Mouse1.79110494
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.76691600
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.76360325
19KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74704158
20JARID2_20064375_ChIP-Seq_MESCs_Mouse1.73618649
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.73572823
22MYB_21317192_ChIP-Seq_ERMYB_Mouse1.72017242
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69845608
24* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.69277008
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67605067
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.65986623
27* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.63235511
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.59696357
29* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.56137895
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55322505
31* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.54804246
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.54540607
33KDM2B_26808549_Chip-Seq_DND41_Human1.51614997
34SCL_19346495_ChIP-Seq_HPC-7_Human1.49841769
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.49163470
36* EP300_21415370_ChIP-Seq_HL-1_Mouse1.49077842
37KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.46934637
38KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.46934637
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.46934637
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45745801
41* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44876875
42EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44327983
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42452361
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.41054204
45* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40915829
46PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40630403
47* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.38666078
48STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.37172420
49* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36593509
50* KDM2B_26808549_Chip-Seq_JURKAT_Human1.35131361
51* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33256294
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32552482
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.31818124
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30113513
55TP53_16413492_ChIP-PET_HCT116_Human1.29576771
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.28919500
57EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28747262
58SPI1_23127762_ChIP-Seq_K562_Human1.26609519
59* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25306874
60MYB_26560356_Chip-Seq_TH1_Human1.25288590
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.24568130
62EED_16625203_ChIP-ChIP_MESCs_Mouse1.24531904
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.23491855
64IRF8_21731497_ChIP-ChIP_J774_Mouse1.22110487
65KDM2B_26808549_Chip-Seq_K562_Human1.21990189
66ESR1_20079471_ChIP-ChIP_T-47D_Human1.21843914
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21704598
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.21655068
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.20853307
70* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20233425
71RXR_22108803_ChIP-Seq_LS180_Human1.19242826
72* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.18093744
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17776305
74* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17069656
75* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17069656
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.16684597
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15946125
78NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15736573
79TRIM28_21343339_ChIP-Seq_HEK293_Human1.15587195
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.15162288
81TBX20_22080862_ChIP-Seq_HEART_Mouse1.14036745
82TBX20_22328084_ChIP-Seq_HEART_Mouse1.14036745
83AHR_22903824_ChIP-Seq_MCF-7_Human1.13355391
84EZH2_27304074_Chip-Seq_ESCs_Mouse1.12198456
85* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11889481
86GATA1_19941826_ChIP-Seq_K562_Human1.11492199
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10915051
88CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10847852
89VDR_24787735_ChIP-Seq_THP-1_Human1.09313669
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08928610
91GBX2_23144817_ChIP-Seq_PC3_Human1.08311674
92DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07985774
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07693557
94* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07406256
95* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07000576
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06053512
97* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04884568
98PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03785546
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03243927
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03200262
101FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02689210
102DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01791596
103E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01335016
104STAT3_23295773_ChIP-Seq_U87_Human1.00836085
105IRF8_27001747_Chip-Seq_BMDM_Mouse1.00761387
106MYB_26560356_Chip-Seq_TH2_Human0.99916784
107NANOG_18555785_Chip-Seq_ESCs_Mouse0.99178198
108PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98660011
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98020346
110RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97703107
111* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97541377
112GATA2_21666600_ChIP-Seq_HMVEC_Human0.97369031
113* AR_19668381_ChIP-Seq_PC3_Human0.97035932
114* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96573545
115* MAF_26560356_Chip-Seq_TH1_Human0.96303777
116TCF4_18268006_ChIP-ChIP_LS174T_Human0.96271562
117OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96242339
118ESR2_21235772_ChIP-Seq_MCF-7_Human0.95865299
119SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95404132
120TCF7_22412390_ChIP-Seq_EML_Mouse0.95316651
121PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95244972
122* GATA3_27048872_Chip-Seq_THYMUS_Human0.95162529
123GATA2_19941826_ChIP-Seq_K562_Human0.94426403
124RING1B_27294783_Chip-Seq_ESCs_Mouse0.94064690
125SMAD4_21799915_ChIP-Seq_A2780_Human0.93775960
126GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93721035
127PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93522353
128STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93478259
129* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91436851
130* P300_19829295_ChIP-Seq_ESCs_Human0.91121301
131SMAD3_21741376_ChIP-Seq_HESCs_Human0.90923112
132* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90355740
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90114961
134RUNX1_27514584_Chip-Seq_MCF-7_Human0.89768882
135OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89339002
136* TCF4_23295773_ChIP-Seq_U87_Human0.89023783
137E2F1_18555785_Chip-Seq_ESCs_Mouse0.88893867
138NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88605323
139SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88160198
140* PRDM14_20953172_ChIP-Seq_ESCs_Human0.88079444
141* FOXA2_19822575_ChIP-Seq_HepG2_Human0.87941050
142* GF1_26923725_Chip-Seq_HPCs_Mouse0.87871310
143MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.87495628
144* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.87394077
145WT1_19549856_ChIP-ChIP_CCG9911_Human0.87127293
146ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86729822
147SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86683467
148P53_22387025_ChIP-Seq_ESCs_Mouse0.86255399
149SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85717038
150SMAD4_21741376_ChIP-Seq_HESCs_Human0.85644235
151CMYC_18555785_Chip-Seq_ESCs_Mouse0.85251628
152* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.84961318
153* BCAT_22108803_ChIP-Seq_LS180_Human0.83950398

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.82906199
2MP0004859_abnormal_synaptic_plasticity3.40391770
3MP0003690_abnormal_glial_cell2.87005782
4MP0005275_abnormal_skin_tensile2.79235411
5MP0005503_abnormal_tendon_morphology2.79167954
6MP0003300_gastrointestinal_ulcer2.56275724
7MP0005464_abnormal_platelet_physiology2.49697659
8MP0002396_abnormal_hematopoietic_system2.34916854
9MP0000920_abnormal_myelination2.34399243
10MP0008004_abnormal_stomach_pH2.24982594
11MP0009780_abnormal_chondrocyte_physiolo2.09434947
12MP0003329_amyloid_beta_deposits2.09214453
13MP0001835_abnormal_antigen_presentation2.09088992
14MP0004885_abnormal_endolymph2.03166973
15MP0003303_peritoneal_inflammation2.00285051
16MP0003191_abnormal_cellular_cholesterol1.98682554
17MP0003635_abnormal_synaptic_transmissio1.96309416
18MP0008569_lethality_at_weaning1.95831394
19MP0004510_myositis1.92413506
20MP0005167_abnormal_blood-brain_barrier1.87374589
21MP0003436_decreased_susceptibility_to1.87092147
22MP0003279_aneurysm1.84464600
23MP0003763_abnormal_thymus_physiology1.84285283
24MP0004084_abnormal_cardiac_muscle1.77499396
25MP0009384_cardiac_valve_regurgitation1.72200591
26MP0001958_emphysema1.72126653
27MP0001790_abnormal_immune_system1.65709455
28MP0005387_immune_system_phenotype1.65709455
29MP0004036_abnormal_muscle_relaxation1.64644701
30MP0000569_abnormal_digit_pigmentation1.63646444
31MP0003045_fibrosis1.62477098
32MP0010155_abnormal_intestine_physiology1.58313712
33MP0004883_abnormal_blood_vessel1.58190554
34MP0000751_myopathy1.55614137
35MP0000703_abnormal_thymus_morphology1.55396834
36MP0002398_abnormal_bone_marrow1.55374462
37MP0001486_abnormal_startle_reflex1.54588694
38MP0002064_seizures1.54400619
39MP0002419_abnormal_innate_immunity1.52167464
40MP0008057_abnormal_DNA_replication1.50611504
41MP0004272_abnormal_basement_membrane1.50591640
42MP0004215_abnormal_myocardial_fiber1.48981249
43MP0009745_abnormal_behavioral_response1.46824996
44MP0003634_abnormal_glial_cell1.46713961
45MP0003950_abnormal_plasma_membrane1.45903363
46MP0004484_altered_response_of1.40014301
47MP0002405_respiratory_system_inflammati1.38372554
48MP0010352_gastrointestinal_tract_polyps1.37726377
49MP0003633_abnormal_nervous_system1.37054773
50MP0005623_abnormal_meninges_morphology1.36677802
51MP0001873_stomach_inflammation1.36105890
52MP0001177_atelectasis1.36071627
53MP0003880_abnormal_central_pattern1.32989346
54MP0002063_abnormal_learning/memory/cond1.32638041
55MP0003075_altered_response_to1.31730417
56MP0000685_abnormal_immune_system1.29340732
57MP0001533_abnormal_skeleton_physiology1.27790685
58MP0000716_abnormal_immune_system1.26424292
59MP0006054_spinal_hemorrhage1.26218121
60MP0005058_abnormal_lysosome_morphology1.25132739
61MP0005025_abnormal_response_to1.24832051
62MP0002998_abnormal_bone_remodeling1.24754901
63MP0001800_abnormal_humoral_immune1.23992864
64MP0002009_preneoplasia1.22946716
65MP0000604_amyloidosis1.21756851
66MP0008260_abnormal_autophagy1.20974536
67MP0008438_abnormal_cutaneous_collagen1.20965389
68MP0001879_abnormal_lymphatic_vessel1.20609272
69MP0002006_tumorigenesis1.18967996
70MP0004381_abnormal_hair_follicle1.18665617
71MP0002166_altered_tumor_susceptibility1.18280919
72MP0003828_pulmonary_edema1.17383831
73MP0002972_abnormal_cardiac_muscle1.15939183
74MP0004947_skin_inflammation1.15047259
75MP0002272_abnormal_nervous_system1.14661494
76MP0002572_abnormal_emotion/affect_behav1.13689772
77MP0002722_abnormal_immune_system1.13375636
78MP0002420_abnormal_adaptive_immunity1.12747737
79MP0003878_abnormal_ear_physiology1.12161030
80MP0005377_hearing/vestibular/ear_phenot1.12161030
81MP0004185_abnormal_adipocyte_glucose1.10120286
82MP0000013_abnormal_adipose_tissue1.08864785
83MP0000689_abnormal_spleen_morphology1.08366837
84MP0005671_abnormal_response_to1.08164285
85MP0001819_abnormal_immune_cell1.07960745
86MP0003631_nervous_system_phenotype1.06916679
87MP0002452_abnormal_antigen_presenting1.06617524
88MP0008961_abnormal_basal_metabolism1.05455258
89MP0002909_abnormal_adrenal_gland1.05182160
90MP0005409_darkened_coat_color1.04887974
91MP0001485_abnormal_pinna_reflex1.04872990
92MP0008877_abnormal_DNA_methylation1.03735371
93MP0001440_abnormal_grooming_behavior1.03029412
94MP0005171_absent_coat_pigmentation1.02713588
95MP0009046_muscle_twitch1.02150745
96MP0010234_abnormal_vibrissa_follicle1.01927040
97MP0010630_abnormal_cardiac_muscle1.01382843
98MP0003448_altered_tumor_morphology1.01067565
99MP0004087_abnormal_muscle_fiber1.00813489
100MP0003705_abnormal_hypodermis_morpholog1.00519223
101MP0005423_abnormal_somatic_nervous0.99816581
102MP0005164_abnormal_response_to0.99623083
103MP0003866_abnormal_defecation0.99600007
104MP0005023_abnormal_wound_healing0.98750519
105MP0006138_congestive_heart_failure0.97837165
106MP0004270_analgesia0.96969057
107MP0003183_abnormal_peptide_metabolism0.96410018
108MP0004130_abnormal_muscle_cell0.96047020
109MP0000428_abnormal_craniofacial_morphol0.95845187
110MP0005075_abnormal_melanosome_morpholog0.95580987
111MP0005551_abnormal_eye_electrophysiolog0.95218260
112MP0003091_abnormal_cell_migration0.94857050
113MP0002127_abnormal_cardiovascular_syste0.94800702
114MP0004085_abnormal_heartbeat0.92337008
115MP0004858_abnormal_nervous_system0.91496620
116MP0006082_CNS_inflammation0.91191257
117MP0005646_abnormal_pituitary_gland0.89469145
118MP0001915_intracranial_hemorrhage0.88911305
119MP0000465_gastrointestinal_hemorrhage0.88579309
120MP0002429_abnormal_blood_cell0.88445650
121MP0005000_abnormal_immune_tolerance0.88424885
122MP0005330_cardiomyopathy0.88140415
123MP0002090_abnormal_vision0.87715130
124MP0003632_abnormal_nervous_system0.87623215
125MP0005166_decreased_susceptibility_to0.87223265
126MP0005620_abnormal_muscle_contractility0.87100790
127MP0001845_abnormal_inflammatory_respons0.86271181
128MP0002133_abnormal_respiratory_system0.85916308
129MP0005388_respiratory_system_phenotype0.85916308
130MP0003566_abnormal_cell_adhesion0.85724222
131MP0005253_abnormal_eye_physiology0.85159265
132MP0002933_joint_inflammation0.84319069
133MP0003137_abnormal_impulse_conducting0.84247410
134MP0000249_abnormal_blood_vessel0.84186920
135MP0002277_abnormal_respiratory_mucosa0.83795146
136MP0000767_abnormal_smooth_muscle0.83759695
137MP0004264_abnormal_extraembryonic_tissu0.83438185
138MP0002132_abnormal_respiratory_system0.82828328
139MP0005310_abnormal_salivary_gland0.82642636
140MP0001544_abnormal_cardiovascular_syste0.82602894
141MP0005385_cardiovascular_system_phenoty0.82602894
142MP0010368_abnormal_lymphatic_system0.81640896
143MP0001851_eye_inflammation0.81508433
144MP0005390_skeleton_phenotype0.80081670
145MP0001968_abnormal_touch/_nociception0.79947806
146MP0002723_abnormal_immune_serum0.78575022
147MP0004742_abnormal_vestibular_system0.78546843
148MP0003122_maternal_imprinting0.78129766
149MP0002067_abnormal_sensory_capabilities0.77443318
150MP0001986_abnormal_taste_sensitivity0.76200264
151MP0003868_abnormal_feces_composition0.71125290
152MP0002168_other_aberrant_phenotype0.70383674
153MP0005621_abnormal_cell_physiology0.67441883
154MP0003252_abnormal_bile_duct0.67066575
155MP0005174_abnormal_tail_pigmentation0.66946977
156MP0002128_abnormal_blood_circulation0.64611206

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.10799204
2Neurofibrillary tangles (HP:0002185)3.71262202
3Prolonged bleeding time (HP:0003010)3.42170986
4Arterial tortuosity (HP:0005116)3.28843657
5Megalencephaly (HP:0001355)3.25530639
6Broad metatarsal (HP:0001783)3.23036260
7Diplopia (HP:0000651)3.20353891
8Abnormality of binocular vision (HP:0011514)3.20353891
9Cerebral inclusion bodies (HP:0100314)3.11105163
10Hemiplegia (HP:0002301)3.09061827
11Gingival bleeding (HP:0000225)3.03136424
12Papilledema (HP:0001085)2.99495335
13Cerebral aneurysm (HP:0004944)2.94076001
14Vascular tortuosity (HP:0004948)2.88541864
15Aplasia involving bones of the upper limbs (HP:0009823)2.86998027
16Aplasia of the phalanges of the hand (HP:0009802)2.86998027
17Aplasia involving bones of the extremities (HP:0009825)2.86998027
18Aortic aneurysm (HP:0004942)2.83906371
19Gastrointestinal infarctions (HP:0005244)2.82173719
20Papillary thyroid carcinoma (HP:0002895)2.80372049
21Myositis (HP:0100614)2.79661433
22Abnormal platelet volume (HP:0011876)2.73564771
23Peritonitis (HP:0002586)2.67315018
24Shallow orbits (HP:0000586)2.65902116
25Aortic dissection (HP:0002647)2.56053647
26Action tremor (HP:0002345)2.55364141
27Epistaxis (HP:0000421)2.54998175
28Recurrent bacterial skin infections (HP:0005406)2.54049901
29Optic neuritis (HP:0100653)2.53825882
30Retrobulbar optic neuritis (HP:0100654)2.53825882
31Supranuclear gaze palsy (HP:0000605)2.52480699
32Conjunctival telangiectasia (HP:0000524)2.51091345
33Increased mean platelet volume (HP:0011877)2.50573385
34Overgrowth (HP:0001548)2.45137575
35Recurrent abscess formation (HP:0002722)2.43651223
36Verrucae (HP:0200043)2.41446193
37Papilloma (HP:0012740)2.41446193
38Orchitis (HP:0100796)2.41010442
39Acanthocytosis (HP:0001927)2.40343449
40Chronic otitis media (HP:0000389)2.38818662
41Intention tremor (HP:0002080)2.38658680
42Increased circulating renin level (HP:0000848)2.37458171
43Ventricular fibrillation (HP:0001663)2.36841583
44Agammaglobulinemia (HP:0004432)2.33852590
45Abnormality of oral frenula (HP:0000190)2.31086615
46Protrusio acetabuli (HP:0003179)2.30208660
47Stomach cancer (HP:0012126)2.28484755
48Abnormality of macrophages (HP:0004311)2.28146393
49T lymphocytopenia (HP:0005403)2.25034414
50Peripheral hypomyelination (HP:0007182)2.25012459
51Stomatitis (HP:0010280)2.23959625
52Abnormality of the fingertips (HP:0001211)2.23581447
53Abnormality of the vasculature of the conjunctiva (HP:0008054)2.22379213
54Centrally nucleated skeletal muscle fibers (HP:0003687)2.21806610
55Spondylolisthesis (HP:0003302)2.19435700
56Clumsiness (HP:0002312)2.16847189
57Spontaneous hematomas (HP:0007420)2.16483964
58Short hallux (HP:0010109)2.16477364
59Dysmetria (HP:0001310)2.15303432
60Gingivitis (HP:0000230)2.14279195
61Recurrent bronchitis (HP:0002837)2.14148184
62Gastrointestinal stroma tumor (HP:0100723)2.12717769
63Subacute progressive viral hepatitis (HP:0006572)2.12209903
64Syringomyelia (HP:0003396)2.10926549
65Spinal cord lesions (HP:0100561)2.10926549
66Abnormality of incisor morphology (HP:0011063)2.08715060
67Abnormality of T cells (HP:0002843)2.08402265
68Abnormality of T cell number (HP:0011839)2.08396603
69Aplasia/Hypoplasia of the hallux (HP:0008362)2.06325159
70Abnormality of the nasal mucosa (HP:0000433)2.03408246
71Abnormal delayed hypersensitivity skin test (HP:0002963)2.03055865
72Aqueductal stenosis (HP:0002410)2.02119105
73Recurrent gram-negative bacterial infections (HP:0005420)2.01319529
74Broad palm (HP:0001169)2.00230522
75Prolonged QT interval (HP:0001657)1.99606457
76Metabolic alkalosis (HP:0200114)1.99577260
77Dysostosis multiplex (HP:0000943)1.99020485
78Trigonocephaly (HP:0000243)1.98411620
79Macroorchidism (HP:0000053)1.96681982
80Sudden death (HP:0001699)1.96161444
81Leukocytosis (HP:0001974)1.96051646
82Elevated erythrocyte sedimentation rate (HP:0003565)1.94791280
83Menorrhagia (HP:0000132)1.93956773
84Nasal polyposis (HP:0100582)1.93858539
85Asymmetric septal hypertrophy (HP:0001670)1.92322914
86Vasculitis (HP:0002633)1.92196936
87Inflammation of the large intestine (HP:0002037)1.91951082
88Exercise-induced myalgia (HP:0003738)1.91170444
89Mitral regurgitation (HP:0001653)1.89609812
90Petechiae (HP:0000967)1.89591898
91Recurrent fungal infections (HP:0002841)1.89452704
92Humeroradial synostosis (HP:0003041)1.89283138
93Synostosis involving the elbow (HP:0003938)1.89283138
94Chronic diarrhea (HP:0002028)1.89010573
95Cellulitis (HP:0100658)1.88713542
96Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.88288573
97Ankyloglossia (HP:0010296)1.87622431
98Autoimmune hemolytic anemia (HP:0001890)1.87062190
99Truncal ataxia (HP:0002078)1.85149583
100Pulmonary embolism (HP:0002204)1.84650378
101Focal seizures (HP:0007359)1.83764386
102Onion bulb formation (HP:0003383)1.83543178
103Broad ribs (HP:0000885)1.82839431
104Gastrointestinal inflammation (HP:0004386)1.82769481
105Eosinophilia (HP:0001880)1.82674716
106Keratoconjunctivitis sicca (HP:0001097)1.81713043
107Hyporeflexia of lower limbs (HP:0002600)1.81128925
108Lymphopenia (HP:0001888)1.80433411
109Hypoplastic left heart (HP:0004383)1.80162096
110Glucose intolerance (HP:0000833)1.79180425
111Chest pain (HP:0100749)1.78594483
112Mitral valve prolapse (HP:0001634)1.78505796
113Hyperlipoproteinemia (HP:0010980)1.77859131
114Slow saccadic eye movements (HP:0000514)1.77570892
115Meningitis (HP:0001287)1.77072580
116Focal motor seizures (HP:0011153)1.76872274
117Syncope (HP:0001279)1.76442752
118Hematochezia (HP:0002573)1.76405813
119Myokymia (HP:0002411)1.76131176
120Annular pancreas (HP:0001734)1.75892868
121Long nose (HP:0003189)1.74591361
122Obstructive sleep apnea (HP:0002870)1.74411671
123Osteolytic defects of the phalanges of the hand (HP:0009771)1.73852262
124Osteolytic defects of the hand bones (HP:0009699)1.73852262
125Encephalitis (HP:0002383)1.73834290
126Periodontitis (HP:0000704)1.73630404
127Osteomyelitis (HP:0002754)1.73442029
128Abnormal glucose tolerance (HP:0001952)1.72684166
129Abnormality of the middle phalanges of the toes (HP:0010183)1.72566444
130Striae distensae (HP:0001065)1.72418202
131Degeneration of the lateral corticospinal tracts (HP:0002314)1.70891752
132Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.70891752
133Atrial fibrillation (HP:0005110)1.70865937
134Vertebral arch anomaly (HP:0008438)1.69577113
135Hypoplasia of the iris (HP:0007676)1.69326397
136Emphysema (HP:0002097)1.68884083
137Pustule (HP:0200039)1.68752928
138Pulmonary infiltrates (HP:0002113)1.68428695
139Visual hallucinations (HP:0002367)1.67910568
140Narrow palate (HP:0000189)1.67417798
141Bronchomalacia (HP:0002780)1.67050649
142Colitis (HP:0002583)1.66476970
143Scanning speech (HP:0002168)1.66420712
144Termporal pattern (HP:0011008)1.66001401
145Insidious onset (HP:0003587)1.66001401
146Hemoptysis (HP:0002105)1.65906112
147Cranial hyperostosis (HP:0004437)1.64898078
148Anteriorly placed anus (HP:0001545)1.64094061
149Visceral angiomatosis (HP:0100761)1.63960426
150Ankle clonus (HP:0011448)1.63582833
151IgM deficiency (HP:0002850)1.63461274
152Disproportionate tall stature (HP:0001519)1.63176943
153Increased CSF protein (HP:0002922)1.63093819
154Aneurysm (HP:0002617)1.62702286
155Abnormality of eosinophils (HP:0001879)1.62174281
156Increased cerebral lipofuscin (HP:0011813)1.60433676
157Granulocytopenia (HP:0001913)1.59707747
158Hemiparesis (HP:0001269)1.59655868
159Recurrent viral infections (HP:0004429)1.59088989
160Urinary urgency (HP:0000012)1.58871720
161Fatigue (HP:0012378)1.58769652
162Abnormality of cells of the lymphoid lineage (HP:0012140)1.58584390
163Primary atrial arrhythmia (HP:0001692)1.58160060
164Recurrent skin infections (HP:0001581)1.57948420
165Hypokalemic alkalosis (HP:0001949)1.57446289
166Premature skin wrinkling (HP:0100678)1.57288809
167Dilatation of the ascending aorta (HP:0005111)1.57087707
168Abnormal eating behavior (HP:0100738)1.57050615
169Hemangiomatosis (HP:0007461)1.56800645
170Absent frontal sinuses (HP:0002688)1.56766371
171Increased variability in muscle fiber diameter (HP:0003557)1.56729051
172Arterial thrombosis (HP:0004420)1.56534347
173Neoplasm of the small intestine (HP:0100833)1.56481201
174J-shaped sella turcica (HP:0002680)1.54803699

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K12.96686497
2LMTK22.96572971
3STK392.66152746
4TRIB32.36546973
5STK102.35469715
6PRPF4B2.31870684
7EPHB12.27631922
8DMPK2.26023924
9MAP3K132.02066104
10GRK61.95188054
11PRKD31.90025582
12NEK91.89847407
13PRKCH1.86271213
14ITK1.85222859
15BMPR21.81000268
16TYRO31.76288471
17EPHA41.74033195
18TEC1.70515017
19PKN21.63194101
20LRRK21.63089751
21CAMK1G1.62424408
22WNK11.50673072
23FES1.48142470
24RIPK11.39540876
25NEK61.38691849
26MST41.38269559
27ACVR1B1.32880105
28FGR1.31471653
29LATS11.31011371
30TNIK1.30851371
31MAP3K91.30633297
32WNK41.30431283
33OXSR11.29924108
34NTRK21.29313522
35FGFR41.28266595
36SGK21.27812869
37PRKCQ1.27324539
38FGFR21.27194363
39TAOK31.25450659
40ROCK21.22968553
41RIPK41.20987335
42CSK1.20953125
43PIK3CG1.20594777
44CAMKK21.19737653
45TTN1.18873855
46PTK2B1.16051480
47PTK61.15176803
48YES11.10753557
49KSR21.09702516
50IKBKE1.09155269
51JAK11.06775458
52CLK11.06297476
53PDK11.05607418
54PRKD21.05210551
55TGFBR21.02908165
56MARK31.02547245
57JAK21.02519947
58SIK31.00909604
59PHKG20.97816190
60PHKG10.97816190
61BLK0.96934307
62CAMK1D0.94143503
63TXK0.93501307
64FYN0.92919808
65PDGFRB0.91350402
66PRKD10.87299506
67NTRK30.86869581
68STK30.86798468
69SGK30.86511374
70MAPK120.86233660
71MYLK0.85304898
72TNK20.85046298
73STK110.83772259
74MAP3K70.83575097
75AKT30.82706044
76LYN0.82078190
77KSR10.81877707
78PAK60.81742879
79IRAK40.81243529
80MARK20.80849446
81HCK0.80410711
82RET0.80209408
83PDPK10.79748748
84CDK50.77363362
85NTRK10.75932243
86MAP3K100.75068316
87FGFR30.74359275
88RAF10.74335695
89PAK30.73817477
90LCK0.72920965
91CAMKK10.72454093
92CDC42BPA0.70648061
93FGFR10.70388178
94SGK4940.69762773
95SGK2230.69762773
96CDK190.69416208
97MAP3K20.68828344
98BTK0.68574880
99STK380.67127837
100BMX0.66701896
101ROCK10.66594263
102TRPM70.66320641
103UHMK10.66103696
104BRD40.65394784
105CDK60.64059705
106SIK20.64048693
107PIM10.64022240
108PDGFRA0.63862609
109GRK50.63716094
110STK40.63149348
111EEF2K0.62404542
112ALK0.62152074
113MAP3K10.61798591
114JAK30.60730097
115NLK0.60701001
116CDK120.59407853
117PKN10.59195922
118STK38L0.58869339
119MAP3K140.57471017
120SIK10.56804484
121MAPK70.55262539
122ZAP700.54423583
123ILK0.52595488
124STK240.52390411
125TYK20.52232460
126CAMK2B0.52129666
127SRC0.50593407
128PTK20.49509224
129PIK3CA0.49009882
130SYK0.48782465
131DAPK20.48610979
132EGFR0.48507745
133INSR0.47913746
134MINK10.47289588
135SGK10.43303442
136MELK0.41351113

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.20743971
2Gastric acid secretion_Homo sapiens_hsa049711.88874277
3Long-term potentiation_Homo sapiens_hsa047201.66599449
4Salivary secretion_Homo sapiens_hsa049701.63056882
5Leukocyte transendothelial migration_Homo sapiens_hsa046701.49688083
6Dorso-ventral axis formation_Homo sapiens_hsa043201.48461502
7Circadian entrainment_Homo sapiens_hsa047131.47254013
8Glutamatergic synapse_Homo sapiens_hsa047241.46445207
9B cell receptor signaling pathway_Homo sapiens_hsa046621.45926762
10Renin secretion_Homo sapiens_hsa049241.44872891
11Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44656335
12Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.44488969
13T cell receptor signaling pathway_Homo sapiens_hsa046601.44392001
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44306469
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.44054652
16Morphine addiction_Homo sapiens_hsa050321.38199774
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30215028
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.27886805
19Dilated cardiomyopathy_Homo sapiens_hsa054141.27834242
20Primary immunodeficiency_Homo sapiens_hsa053401.25648758
21Phosphatidylinositol signaling system_Homo sapiens_hsa040701.25530190
22Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.24786715
23cGMP-PKG signaling pathway_Homo sapiens_hsa040221.24172483
24Phospholipase D signaling pathway_Homo sapiens_hsa040721.22758643
25Platelet activation_Homo sapiens_hsa046111.22304347
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.21220557
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.18854536
28Cholinergic synapse_Homo sapiens_hsa047251.16075255
29Acute myeloid leukemia_Homo sapiens_hsa052211.15523266
30GABAergic synapse_Homo sapiens_hsa047271.15051534
31Oxytocin signaling pathway_Homo sapiens_hsa049211.14790762
32Long-term depression_Homo sapiens_hsa047301.13643371
33Chemokine signaling pathway_Homo sapiens_hsa040621.10463434
34Olfactory transduction_Homo sapiens_hsa047401.10091437
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10079154
36cAMP signaling pathway_Homo sapiens_hsa040241.10024865
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.09232120
38Pancreatic secretion_Homo sapiens_hsa049721.08254880
39Dopaminergic synapse_Homo sapiens_hsa047281.07791029
40Estrogen signaling pathway_Homo sapiens_hsa049151.06762427
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.05797333
42Thyroid cancer_Homo sapiens_hsa052161.05777421
43Renal cell carcinoma_Homo sapiens_hsa052111.04536970
44Measles_Homo sapiens_hsa051621.02612403
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.02423856
46Amphetamine addiction_Homo sapiens_hsa050311.01966303
47VEGF signaling pathway_Homo sapiens_hsa043701.00770819
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00632855
49Osteoclast differentiation_Homo sapiens_hsa043801.00497846
50FoxO signaling pathway_Homo sapiens_hsa040680.99876171
51Viral myocarditis_Homo sapiens_hsa054160.99860472
52Insulin secretion_Homo sapiens_hsa049110.99769896
53Focal adhesion_Homo sapiens_hsa045100.99760972
54Sphingolipid signaling pathway_Homo sapiens_hsa040710.99424675
55Malaria_Homo sapiens_hsa051440.99377771
56Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.99030423
57Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98805449
58Prostate cancer_Homo sapiens_hsa052150.98474360
59Rap1 signaling pathway_Homo sapiens_hsa040150.97886703
60GnRH signaling pathway_Homo sapiens_hsa049120.97871286
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97387465
62Calcium signaling pathway_Homo sapiens_hsa040200.95978528
63Protein digestion and absorption_Homo sapiens_hsa049740.93241633
64Fatty acid biosynthesis_Homo sapiens_hsa000610.92573899
65Axon guidance_Homo sapiens_hsa043600.92531215
66Endocytosis_Homo sapiens_hsa041440.90432256
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90374162
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.89904908
69Graft-versus-host disease_Homo sapiens_hsa053320.89741405
70Choline metabolism in cancer_Homo sapiens_hsa052310.88425342
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87872774
72Nicotine addiction_Homo sapiens_hsa050330.87391575
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87067393
74Thyroid hormone synthesis_Homo sapiens_hsa049180.86884234
75Hepatitis B_Homo sapiens_hsa051610.86863656
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86141710
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85558415
78Proteoglycans in cancer_Homo sapiens_hsa052050.84710494
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83843136
80Autoimmune thyroid disease_Homo sapiens_hsa053200.83564628
81Pancreatic cancer_Homo sapiens_hsa052120.81850253
82Glioma_Homo sapiens_hsa052140.81497831
83Gap junction_Homo sapiens_hsa045400.81056475
84Cocaine addiction_Homo sapiens_hsa050300.79822403
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.79763753
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79106287
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79086961
88mTOR signaling pathway_Homo sapiens_hsa041500.78324797
89Adherens junction_Homo sapiens_hsa045200.78220987
90Melanogenesis_Homo sapiens_hsa049160.77470801
91Tuberculosis_Homo sapiens_hsa051520.74954080
92Staphylococcus aureus infection_Homo sapiens_hsa051500.74759774
93Inositol phosphate metabolism_Homo sapiens_hsa005620.74007958
94MAPK signaling pathway_Homo sapiens_hsa040100.73778123
95Toxoplasmosis_Homo sapiens_hsa051450.72202739
96Cardiac muscle contraction_Homo sapiens_hsa042600.72062082
97Renin-angiotensin system_Homo sapiens_hsa046140.71818052
98Small cell lung cancer_Homo sapiens_hsa052220.71741259
99Pathways in cancer_Homo sapiens_hsa052000.70092652
100Tight junction_Homo sapiens_hsa045300.69258226
101Non-small cell lung cancer_Homo sapiens_hsa052230.68585995
102Serotonergic synapse_Homo sapiens_hsa047260.68296267
103Allograft rejection_Homo sapiens_hsa053300.67680444
104Ras signaling pathway_Homo sapiens_hsa040140.67098979
105Colorectal cancer_Homo sapiens_hsa052100.67098452
106Type II diabetes mellitus_Homo sapiens_hsa049300.66748894
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66538581
108Amoebiasis_Homo sapiens_hsa051460.66402457
109ECM-receptor interaction_Homo sapiens_hsa045120.64497583
110ErbB signaling pathway_Homo sapiens_hsa040120.64066357
111Prolactin signaling pathway_Homo sapiens_hsa049170.62529101
112Mineral absorption_Homo sapiens_hsa049780.62232970
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61236573
114Phototransduction_Homo sapiens_hsa047440.61127331
115Leishmaniasis_Homo sapiens_hsa051400.60265020
116Wnt signaling pathway_Homo sapiens_hsa043100.59372891
117Hepatitis C_Homo sapiens_hsa051600.58516312
118TGF-beta signaling pathway_Homo sapiens_hsa043500.57991473
119Chronic myeloid leukemia_Homo sapiens_hsa052200.57592743
120Circadian rhythm_Homo sapiens_hsa047100.57219015
121Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56577487
122MicroRNAs in cancer_Homo sapiens_hsa052060.56138706
123Endometrial cancer_Homo sapiens_hsa052130.55885173
124Hematopoietic cell lineage_Homo sapiens_hsa046400.55042617
125NF-kappa B signaling pathway_Homo sapiens_hsa040640.54904234
126HIF-1 signaling pathway_Homo sapiens_hsa040660.54742301
127Histidine metabolism_Homo sapiens_hsa003400.54698850
128Salmonella infection_Homo sapiens_hsa051320.54672475
129Insulin resistance_Homo sapiens_hsa049310.51722472
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51444168
131Shigellosis_Homo sapiens_hsa051310.49944719

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