ADGB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)7.45166680
2axonemal dynein complex assembly (GO:0070286)7.12747811
3cilium movement (GO:0003341)7.08303734
4left/right pattern formation (GO:0060972)6.91637870
5epithelial cilium movement (GO:0003351)6.02622852
6fusion of sperm to egg plasma membrane (GO:0007342)6.01071671
7cilium assembly (GO:0042384)5.87336746
8microtubule bundle formation (GO:0001578)5.58799781
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.28283912
10multicellular organism reproduction (GO:0032504)5.24995716
11acrosome assembly (GO:0001675)5.18744152
12sperm motility (GO:0030317)5.15140375
13regulation of dendritic cell antigen processing and presentation (GO:0002604)4.95035637
14regulation of activation of Janus kinase activity (GO:0010533)4.88341563
15axoneme assembly (GO:0035082)4.83330972
16cellular component assembly involved in morphogenesis (GO:0010927)4.74478352
17reproduction (GO:0000003)4.71900444
18cell wall macromolecule catabolic process (GO:0016998)4.60824602
19cell wall macromolecule metabolic process (GO:0044036)4.60824602
20cilium morphogenesis (GO:0060271)4.57121846
21vitamin transmembrane transport (GO:0035461)4.55190894
22microtubule-based movement (GO:0007018)4.51899546
23ventricular system development (GO:0021591)4.49875088
24protein localization to cilium (GO:0061512)4.44083282
25positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.41891727
26centriole assembly (GO:0098534)4.40090287
27sperm-egg recognition (GO:0035036)4.33191641
28plasma membrane fusion (GO:0045026)4.31670489
29cell-cell recognition (GO:0009988)4.25992742
30regulation of interleukin-5 production (GO:0032674)4.18787282
31acrosome reaction (GO:0007340)4.18260463
32one-carbon compound transport (GO:0019755)4.14002164
33cell projection assembly (GO:0030031)4.12872505
34motile cilium assembly (GO:0044458)4.11715286
35primary alcohol catabolic process (GO:0034310)4.05904868
36negative regulation of humoral immune response (GO:0002921)4.05722802
37regulation of microtubule-based movement (GO:0060632)3.97794048
38sperm capacitation (GO:0048240)3.89495113
39regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.88887024
40negative regulation of B cell mediated immunity (GO:0002713)3.83898486
41negative regulation of immunoglobulin mediated immune response (GO:0002890)3.83898486
42natural killer cell mediated immunity (GO:0002228)3.83356897
43natural killer cell mediated cytotoxicity (GO:0042267)3.83356897
44diterpenoid biosynthetic process (GO:0016102)3.82996555
45lateral ventricle development (GO:0021670)3.81000091
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.79909418
47germinal center formation (GO:0002467)3.75325456
48spermatid development (GO:0007286)3.73805079
49positive regulation of antigen processing and presentation (GO:0002579)3.73479154
50ethanol metabolic process (GO:0006067)3.67528116
51single fertilization (GO:0007338)3.64977643
52response to xenobiotic stimulus (GO:0009410)3.63065298
53positive regulation by symbiont of host defense response (GO:0052509)3.62347525
54modulation by symbiont of host defense response (GO:0052031)3.62347525
55modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.62347525
56modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.62347525
57positive regulation by organism of defense response of other organism involved in symbiotic interact3.62347525
58modulation by symbiont of host immune response (GO:0052553)3.62347525
59regulation of apoptotic cell clearance (GO:2000425)3.60969181
60retinal rod cell development (GO:0046548)3.60548228
61glomerular epithelial cell development (GO:0072310)3.59612889
62NIK/NF-kappaB signaling (GO:0038061)3.56284185
63regulation of integrin activation (GO:0033623)3.55412313
64retinal cone cell development (GO:0046549)3.54729970
65binding of sperm to zona pellucida (GO:0007339)3.53572707
66photoreceptor cell maintenance (GO:0045494)3.48607684
67pyrimidine-containing compound transmembrane transport (GO:0072531)3.47492808
68tolerance induction (GO:0002507)3.46402853
69neutrophil activation involved in immune response (GO:0002283)3.45998225
70centriole replication (GO:0007099)3.42589464
71regulation of interleukin-13 production (GO:0032656)3.42378396
72regulation of germinal center formation (GO:0002634)3.41224999
73response to peptidoglycan (GO:0032494)3.38414999
74regulation of cilium movement (GO:0003352)3.33336115
75microtubule polymerization or depolymerization (GO:0031109)3.29253279
76leukocyte mediated cytotoxicity (GO:0001909)3.23812373
77determination of left/right symmetry (GO:0007368)3.23311734
78positive regulation of heat generation (GO:0031652)3.22703783
79antigen processing and presentation of endogenous antigen (GO:0019883)3.21772313
80piRNA metabolic process (GO:0034587)3.21226659
81negative regulation of inclusion body assembly (GO:0090084)3.20310337
82microtubule depolymerization (GO:0007019)3.18773908
83neural tube formation (GO:0001841)3.17230938
84hydrogen peroxide biosynthetic process (GO:0050665)3.16997841
85regulation of antigen processing and presentation (GO:0002577)3.15694784
86left/right axis specification (GO:0070986)3.14836949
87positive regulation of T-helper 1 type immune response (GO:0002827)3.11161060
88T-helper 1 type immune response (GO:0042088)3.10817063
89determination of bilateral symmetry (GO:0009855)3.08912886
90apoptotic cell clearance (GO:0043277)3.07607959
91positive regulation of interleukin-17 production (GO:0032740)3.04203441
92positive regulation of cellular amide metabolic process (GO:0034250)3.04197092
93positive regulation of Cdc42 GTPase activity (GO:0043089)3.02296918
94cytoplasmic microtubule organization (GO:0031122)3.01479909
95male meiosis (GO:0007140)3.00564477
96specification of symmetry (GO:0009799)3.00122012
97response to muramyl dipeptide (GO:0032495)2.99628085
98response to type I interferon (GO:0034340)2.97885657
99regulation of mononuclear cell migration (GO:0071675)2.95683892
100regulation of T-helper 1 cell differentiation (GO:0045625)2.95573075
101positive regulation of T-helper cell differentiation (GO:0045624)2.95306798
102neutrophil mediated immunity (GO:0002446)2.95214589
103macroautophagy (GO:0016236)2.95205314
104negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.94462740
105regulation of fever generation (GO:0031620)2.93149081
106fertilization (GO:0009566)2.92827098
107type I interferon signaling pathway (GO:0060337)2.91306349
108cellular response to type I interferon (GO:0071357)2.91306349
109positive regulation of cell adhesion mediated by integrin (GO:0033630)2.91175507
110positive regulation of interleukin-12 production (GO:0032735)2.90644510
111neutrophil activation (GO:0042119)2.87546011
112sexual reproduction (GO:0019953)2.86066989
113macrophage activation involved in immune response (GO:0002281)2.84698082
114granulocyte activation (GO:0036230)2.83070614
115intraciliary transport (GO:0042073)2.82941797
116regulation of macrophage chemotaxis (GO:0010758)2.82630269
117regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.81860910
118exogenous drug catabolic process (GO:0042738)2.81694613
119smoothened signaling pathway (GO:0007224)2.80258592
120regulation of memory T cell differentiation (GO:0043380)2.79651864
121cytokine secretion (GO:0050663)2.78358183
122positive regulation of tolerance induction (GO:0002645)2.78324109
123intra-S DNA damage checkpoint (GO:0031573)2.78186491
124defense response to protozoan (GO:0042832)2.77820057
125lung epithelium development (GO:0060428)2.77015070
126respiratory burst (GO:0045730)2.76964318
127positive regulation of smoothened signaling pathway (GO:0045880)2.76570084
128positive regulation of T cell migration (GO:2000406)2.76419028
129microglial cell activation (GO:0001774)2.75651303
130reactive oxygen species biosynthetic process (GO:1903409)2.75136901
131regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.74869799
132positive regulation of monocyte chemotaxis (GO:0090026)2.74426892
133positive regulation of cholesterol efflux (GO:0010875)2.72100478
134ethanol oxidation (GO:0006069)2.71806388
135superoxide anion generation (GO:0042554)2.71228529
136positive regulation of gamma-delta T cell activation (GO:0046645)2.70762099
137cellular response to ATP (GO:0071318)2.70237295
138negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.69544949
139negative regulation of cell killing (GO:0031342)2.69544949
140detection of molecule of bacterial origin (GO:0032490)2.68887150
141organelle assembly (GO:0070925)2.67848751
142nucleoside diphosphate phosphorylation (GO:0006165)2.67078496
143iron ion import (GO:0097286)2.66914900
144microtubule severing (GO:0051013)2.66795860
145leukotriene metabolic process (GO:0006691)2.65503589
146negative regulation of T cell differentiation in thymus (GO:0033085)2.64888296
147positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.64751770
148microtubule-based process (GO:0007017)2.64531535
149retinoic acid metabolic process (GO:0042573)2.64046577
150detection of biotic stimulus (GO:0009595)2.63903672
151lymphocyte chemotaxis (GO:0048247)2.63271452
152regulation of Cdc42 GTPase activity (GO:0043088)2.62970820
153positive regulation of interferon-alpha production (GO:0032727)2.62728381
154drug catabolic process (GO:0042737)2.58096303
155regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.57969419
156cilium organization (GO:0044782)2.57508583
157regulation of collateral sprouting (GO:0048670)2.55761541
158regulation of cilium assembly (GO:1902017)2.51955209
159interkinetic nuclear migration (GO:0022027)2.50129703
160negative regulation of cytosolic calcium ion concentration (GO:0051481)2.48905090
161establishment of apical/basal cell polarity (GO:0035089)2.35826558
162appendage development (GO:0048736)2.34214970
163limb development (GO:0060173)2.34214970
164phosphatidylethanolamine biosynthetic process (GO:0006646)2.33355877
165O-glycan processing (GO:0016266)2.32828712
166glutathione derivative metabolic process (GO:1901685)2.27592957
167glutathione derivative biosynthetic process (GO:1901687)2.27592957
168phosphatidylethanolamine metabolic process (GO:0046337)2.25811769
169negative regulation of complement activation (GO:0045916)2.25741539
170establishment or maintenance of monopolar cell polarity (GO:0061339)2.21158379
171establishment of monopolar cell polarity (GO:0061162)2.21158379
172negative regulation of adaptive immune response (GO:0002820)2.20639358
173protein polyglutamylation (GO:0018095)2.20614385
174lateral sprouting from an epithelium (GO:0060601)2.16668874
175excretion (GO:0007588)2.15446112
176cellular response to ethanol (GO:0071361)2.12582063
177regulation of smoothened signaling pathway (GO:0008589)2.12346321
178import into cell (GO:0098657)2.11409518
179benzene-containing compound metabolic process (GO:0042537)2.11332086
180sphingoid metabolic process (GO:0046519)2.10479088
181striated muscle atrophy (GO:0014891)2.09628895
182retinol metabolic process (GO:0042572)2.09239784

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.95308446
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.63749126
3IRF8_27001747_Chip-Seq_BMDM_Mouse2.96809592
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.96510793
5Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.89505631
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.74151791
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.49089934
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.44433838
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43119862
10GBX2_23144817_ChIP-Seq_PC3_Human2.26887384
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.24337984
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.24208653
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.22849058
14PIAS1_25552417_ChIP-Seq_VCAP_Human2.07605667
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04863083
16AHR_22903824_ChIP-Seq_MCF-7_Human2.03365688
17AR_21572438_ChIP-Seq_LNCaP_Human1.97017611
18ARNT_22903824_ChIP-Seq_MCF-7_Human1.83421133
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81720984
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78027061
21EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.76324331
22NR3C1_21868756_ChIP-Seq_MCF10A_Human1.75464931
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74083053
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73308458
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.69251350
26PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.67619852
27FOXM1_26456572_ChIP-Seq_MCF-7_Human1.66220569
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.65472136
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65040331
30TAF15_26573619_Chip-Seq_HEK293_Human1.62316434
31TCF4_23295773_ChIP-Seq_U87_Human1.60057410
32VDR_24787735_ChIP-Seq_THP-1_Human1.59976959
33TP53_16413492_ChIP-PET_HCT116_Human1.53589749
34TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50352924
35CTNNB1_20460455_ChIP-Seq_HCT116_Human1.50095026
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47599770
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46250652
38STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.44751240
39TP63_23658742_ChIP-Seq_EP156T_Human1.40811046
40TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40587953
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.40574814
42P300_19829295_ChIP-Seq_ESCs_Human1.37414212
43ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37352517
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.37040171
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36770007
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36366034
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36341072
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35920902
49PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35810981
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.35810491
51TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.34592104
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33271661
53IGF1R_20145208_ChIP-Seq_DFB_Human1.32625129
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.31086375
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30702359
56FUS_26573619_Chip-Seq_HEK293_Human1.30676169
57TP53_18474530_ChIP-ChIP_U2OS_Human1.29135876
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.26597185
59ELK4_26923725_Chip-Seq_MESODERM_Mouse1.25730616
60EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23865085
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.23657962
62P53_22387025_ChIP-Seq_ESCs_Mouse1.23623093
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21164390
64PRDM14_20953172_ChIP-Seq_ESCs_Human1.20281435
65STAT3_18555785_Chip-Seq_ESCs_Mouse1.18783642
66CMYC_18555785_Chip-Seq_ESCs_Mouse1.18642635
67CDX2_22108803_ChIP-Seq_LS180_Human1.18410588
68SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18237355
69SMAD3_21741376_ChIP-Seq_HESCs_Human1.17686649
70STAT1_17558387_ChIP-Seq_HELA_Human1.17332578
71BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17196857
72SMAD4_21741376_ChIP-Seq_EPCs_Human1.16892959
73PU_27001747_Chip-Seq_BMDM_Mouse1.16801385
74PU1_27457419_Chip-Seq_LIVER_Mouse1.16792570
75MYB_21317192_ChIP-Seq_ERMYB_Mouse1.16438126
76AR_25329375_ChIP-Seq_VCAP_Human1.16425783
77SOX2_18555785_Chip-Seq_ESCs_Mouse1.16410855
78AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.16304406
79CBP_20019798_ChIP-Seq_JUKART_Human1.14120132
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14120132
81TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.13755738
82KDM2B_26808549_Chip-Seq_REH_Human1.13548962
83SCL_19346495_ChIP-Seq_HPC-7_Human1.13399261
84RUNX2_22187159_ChIP-Seq_PCA_Human1.13111856
85OCT4_18555785_Chip-Seq_ESCs_Mouse1.13045851
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13042853
87SPI1_23127762_ChIP-Seq_K562_Human1.12905448
88KLF4_18555785_Chip-Seq_ESCs_Mouse1.11903430
89FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.11882134
90VDR_22108803_ChIP-Seq_LS180_Human1.11814941
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11642777
92EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10769711
93ETV1_20927104_ChIP-Seq_GIST48_Human1.10731835
94E2F1_18555785_Chip-Seq_ESCs_Mouse1.10616650
95P300_18555785_Chip-Seq_ESCs_Mouse1.10338015
96ESRRB_18555785_Chip-Seq_ESCs_Mouse1.10181760
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10092930
98GF1_26923725_Chip-Seq_HPCs_Mouse1.09908689
99ZFX_18555785_Chip-Seq_ESCs_Mouse1.09875693
100ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09585490
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.09476878
102EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08804970
103OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08589973
104ZNF274_21170338_ChIP-Seq_K562_Hela1.08401213
105RXR_22108803_ChIP-Seq_LS180_Human1.07746592
106TBL1_22424771_ChIP-Seq_293T_Human1.06955213
107PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06906413
108CTCF_18555785_Chip-Seq_ESCs_Mouse1.06410923
109PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.06185907
110NMYC_18555785_Chip-Seq_ESCs_Mouse1.05904734
111RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05789099
112CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05343106
113DROSHA_22980978_ChIP-Seq_HELA_Human1.05331483
114HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05075707
115CRX_20693478_ChIP-Seq_RETINA_Mouse1.04600215
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04431308
117SMRT_27268052_Chip-Seq_Bcells_Human1.03296329
118RUNX_20019798_ChIP-Seq_JUKART_Human1.02914865
119MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02197874
120CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02183129
121FLI1_21867929_ChIP-Seq_TH2_Mouse1.01994081
122CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01679366
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00334693
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00334693
125FOXA2_19822575_ChIP-Seq_HepG2_Human0.99777089
126TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99656664
127SMAD4_21741376_ChIP-Seq_HESCs_Human0.99167050
128SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98416017
129SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98355554
130ER_23166858_ChIP-Seq_MCF-7_Human0.98052637
131NFYA_21822215_ChIP-Seq_K562_Human0.97931294
132MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97886619
133CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97536034
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97192439
135SOX2_21211035_ChIP-Seq_LN229_Gbm0.97154469
136ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97111973
137FOXA1_25552417_ChIP-Seq_VCAP_Human0.96790680
138KAP1_22055183_ChIP-Seq_ESCs_Mouse0.96775934
139GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96732233
140EWS_26573619_Chip-Seq_HEK293_Human0.96329412
141NFYB_21822215_ChIP-Seq_K562_Human0.96087541
142LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95943622
143AR_19668381_ChIP-Seq_PC3_Human0.95850471
144GATA2_21666600_ChIP-Seq_HMVEC_Human0.95649968
145GATA1_19941826_ChIP-Seq_K562_Human0.95514095
146TAL1_26923725_Chip-Seq_HPCs_Mouse0.95314541
147PHF8_20622853_ChIP-Seq_HELA_Human0.95129469
148NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94746337
149VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94442938
150SMAD1_18555785_Chip-Seq_ESCs_Mouse0.94393115
151SMAD_19615063_ChIP-ChIP_OVARY_Human0.93947849
152LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93811468
153GATA1_26923725_Chip-Seq_HPCs_Mouse0.93218598
154VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92247286
155FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91943614
156STAT4_19710469_ChIP-ChIP_TH1__Mouse0.91511696
157TCF4_22108803_ChIP-Seq_LS180_Human0.91057210
158SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90755525
159ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90567172
160PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89400481
161SMAD4_21799915_ChIP-Seq_A2780_Human0.89254307
162BRD4_27068464_Chip-Seq_AML-cells_Mouse0.88040292
163MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.87855615
164LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87171265
165BCAT_22108803_ChIP-Seq_LS180_Human0.86890974
166STAT3_23295773_ChIP-Seq_U87_Human0.86363720

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat6.22121659
2MP0008875_abnormal_xenobiotic_pharmacok4.53027879
3MP0000569_abnormal_digit_pigmentation4.32128154
4MP0005410_abnormal_fertilization4.27192868
5MP0002132_abnormal_respiratory_system3.93713514
6MP0000685_abnormal_immune_system3.82925520
7MP0004043_abnormal_pH_regulation3.61809879
8MP0001835_abnormal_antigen_presentation3.51967093
9MP0000383_abnormal_hair_follicle3.24508032
10MP0002876_abnormal_thyroid_physiology3.05616282
11MP0001984_abnormal_olfaction2.92187757
12MP0005387_immune_system_phenotype2.77840239
13MP0001790_abnormal_immune_system2.77840239
14MP0003183_abnormal_peptide_metabolism2.74363767
15MP0001348_abnormal_lacrimal_gland2.63865568
16MP0006082_CNS_inflammation2.61895000
17MP0009780_abnormal_chondrocyte_physiolo2.61267134
18MP0005310_abnormal_salivary_gland2.53961623
19MP0003878_abnormal_ear_physiology2.48400052
20MP0005377_hearing/vestibular/ear_phenot2.48400052
21MP0004510_myositis2.37931127
22MP0002148_abnormal_hypersensitivity_rea2.33844393
23MP0009785_altered_susceptibility_to2.31817714
24MP0010678_abnormal_skin_adnexa2.31568080
25MP0003172_abnormal_lysosome_physiology2.28976328
26MP0001873_stomach_inflammation2.25972410
27MP0005645_abnormal_hypothalamus_physiol2.25612388
28MP0002419_abnormal_innate_immunity2.19426562
29MP0005025_abnormal_response_to2.18003482
30MP0005000_abnormal_immune_tolerance2.16922420
31MP0001346_abnormal_lacrimal_gland2.14406652
32MP0003656_abnormal_erythrocyte_physiolo2.12615361
33MP0004133_heterotaxia2.11560994
34MP0003950_abnormal_plasma_membrane2.08455603
35MP0003724_increased_susceptibility_to2.08235472
36MP0003436_decreased_susceptibility_to2.06127730
37MP0002282_abnormal_trachea_morphology2.05796407
38MP0002877_abnormal_melanocyte_morpholog2.02016917
39MP0005058_abnormal_lysosome_morphology1.95093366
40MP0003136_yellow_coat_color1.78382505
41MP0005551_abnormal_eye_electrophysiolog1.78188901
42MP0001800_abnormal_humoral_immune1.74511302
43MP0005671_abnormal_response_to1.73616621
44MP0005083_abnormal_biliary_tract1.73168232
45MP0004947_skin_inflammation1.72934778
46MP0002405_respiratory_system_inflammati1.68804987
47MP0009278_abnormal_bone_marrow1.67785012
48MP0001851_eye_inflammation1.66911769
49MP0001485_abnormal_pinna_reflex1.66302627
50MP0005174_abnormal_tail_pigmentation1.62836809
51MP0002160_abnormal_reproductive_system1.60931440
52MP0009046_muscle_twitch1.60425797
53MP0002452_abnormal_antigen_presenting1.57861526
54MP0002723_abnormal_immune_serum1.57850585
55MP0005395_other_phenotype1.57228764
56MP0003252_abnormal_bile_duct1.51477870
57MP0002693_abnormal_pancreas_physiology1.49497816
58MP0000015_abnormal_ear_pigmentation1.46844395
59MP0003698_abnormal_male_reproductive1.46090679
60MP0005253_abnormal_eye_physiology1.42522167
61MP0001845_abnormal_inflammatory_respons1.42009263
62MP0003045_fibrosis1.38679125
63MP0003195_calcinosis1.38391640
64MP0003303_peritoneal_inflammation1.38087211
65MP0002928_abnormal_bile_duct1.37163890
66MP0001533_abnormal_skeleton_physiology1.32947442
67MP0005464_abnormal_platelet_physiology1.32282004
68MP0003300_gastrointestinal_ulcer1.31119437
69MP0002138_abnormal_hepatobiliary_system1.29730248
70MP0000371_diluted_coat_color1.27646122
71MP0001819_abnormal_immune_cell1.25833928
72MP0003075_altered_response_to1.25828152
73MP0002277_abnormal_respiratory_mucosa1.23293647
74MP0002420_abnormal_adaptive_immunity1.21960173
75MP0001929_abnormal_gametogenesis1.21295129
76MP0004782_abnormal_surfactant_physiolog1.19422413
77MP0005647_abnormal_sex_gland1.15591594
78MP0008789_abnormal_olfactory_epithelium1.11001796
79MP0000427_abnormal_hair_cycle1.10679692
80MP0008469_abnormal_protein_level1.10278589
81MP0002653_abnormal_ependyma_morphology1.08385146
82MP0005646_abnormal_pituitary_gland1.03018867
83MP0005085_abnormal_gallbladder_physiolo1.01486136
84MP0005623_abnormal_meninges_morphology0.99974710
85MP0005171_absent_coat_pigmentation0.98889669
86MP0001486_abnormal_startle_reflex0.98435501
87MP0010386_abnormal_urinary_bladder0.97918313
88MP0005389_reproductive_system_phenotype0.97532540
89MP0002006_tumorigenesis0.97329250
90MP0003879_abnormal_hair_cell0.96304190
91MP0004019_abnormal_vitamin_homeostasis0.95330982
92MP0000604_amyloidosis0.92875310
93MP0003448_altered_tumor_morphology0.90902326
94MP0003633_abnormal_nervous_system0.90894744
95MP0002166_altered_tumor_susceptibility0.90468499
96MP0002229_neurodegeneration0.89503337
97MP0001324_abnormal_eye_pigmentation0.89176125
98MP0002168_other_aberrant_phenotype0.88775402
99MP0004264_abnormal_extraembryonic_tissu0.87186292
100MP0001764_abnormal_homeostasis0.86449177
101MP0009764_decreased_sensitivity_to0.86203684
102MP0002998_abnormal_bone_remodeling0.86102224
103MP0002136_abnormal_kidney_physiology0.85493506
104MP0002735_abnormal_chemical_nociception0.85210188
105MP0000372_irregular_coat_pigmentation0.85036669
106MP0000716_abnormal_immune_system0.84969768
107MP0010155_abnormal_intestine_physiology0.84487021
108MP0000470_abnormal_stomach_morphology0.84159439
109MP0002909_abnormal_adrenal_gland0.83060985
110MP0005636_abnormal_mineral_homeostasis0.82300416
111MP0005397_hematopoietic_system_phenotyp0.82228428
112MP0001545_abnormal_hematopoietic_system0.82228428
113MP0008961_abnormal_basal_metabolism0.80876050
114MP0005164_abnormal_response_to0.79042033
115MP0001853_heart_inflammation0.78664401
116MP0009763_increased_sensitivity_to0.77216071
117MP0004883_abnormal_blood_vessel0.75503285
118MP0003943_abnormal_hepatobiliary_system0.75268373
119MP0005670_abnormal_white_adipose0.73958160
120MP0002332_abnormal_exercise_endurance0.71975914
121MP0000465_gastrointestinal_hemorrhage0.71882536
122MP0005220_abnormal_exocrine_pancreas0.71798840
123MP0003890_abnormal_embryonic-extraembry0.71777357
124MP0009745_abnormal_behavioral_response0.71374544
125MP0005257_abnormal_intraocular_pressure0.69375557
126MP0001968_abnormal_touch/_nociception0.68896938
127MP0000613_abnormal_salivary_gland0.68023121
128MP0003453_abnormal_keratinocyte_physiol0.67757102
129MP0009643_abnormal_urine_homeostasis0.67532786
130MP0003763_abnormal_thymus_physiology0.66718417
131MP0008995_early_reproductive_senescence0.66470236
132MP0002135_abnormal_kidney_morphology0.65318587
133MP0005365_abnormal_bile_salt0.63761781
134MP0006054_spinal_hemorrhage0.63698591
135MP0001963_abnormal_hearing_physiology0.63371841
136MP0001970_abnormal_pain_threshold0.62835400
137MP0005408_hypopigmentation0.62591627
138MP0003631_nervous_system_phenotype0.62248854
139MP0005195_abnormal_posterior_eye0.62245851
140MP0009703_decreased_birth_body0.62071730
141MP0001664_abnormal_digestion0.61992634
142MP0004858_abnormal_nervous_system0.61314671
143MP0005535_abnormal_body_temperature0.61182480
144MP0002161_abnormal_fertility/fecundity0.61131010
145MP0008057_abnormal_DNA_replication0.61010967
146MP0000681_abnormal_thyroid_gland0.60898250
147MP0004381_abnormal_hair_follicle0.60589771
148MP0001986_abnormal_taste_sensitivity0.60108562
149MP0002398_abnormal_bone_marrow0.59900014
150MP0000026_abnormal_inner_ear0.59603419
151MP0002133_abnormal_respiratory_system0.58926681
152MP0005388_respiratory_system_phenotype0.58926681
153MP0002734_abnormal_mechanical_nocicepti0.58636737
154MP0008877_abnormal_DNA_methylation0.58548726
155MP0005376_homeostasis/metabolism_phenot0.58116174
156MP0002210_abnormal_sex_determination0.57740980
157MP0000566_synostosis0.57232538
158MP0005503_abnormal_tendon_morphology0.56874644
159MP0009765_abnormal_xenobiotic_induced0.56149170
160MP0003690_abnormal_glial_cell0.55539493
161MP0002095_abnormal_skin_pigmentation0.54855740
162MP0001501_abnormal_sleep_pattern0.53894269
163MP0000538_abnormal_urinary_bladder0.51840554
164MP0005390_skeleton_phenotype0.51743510
165MP0001765_abnormal_ion_homeostasis0.51136229

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.14160062
2Abnormal respiratory motile cilium physiology (HP:0012261)8.13173122
3Abnormal ciliary motility (HP:0012262)7.73993940
4Rhinitis (HP:0012384)6.80885770
5Dynein arm defect of respiratory motile cilia (HP:0012255)6.72631226
6Absent/shortened dynein arms (HP:0200106)6.72631226
7Abnormal respiratory epithelium morphology (HP:0012253)6.28107855
8Abnormal respiratory motile cilium morphology (HP:0005938)6.28107855
9Nasal polyposis (HP:0100582)5.41201827
10Chronic bronchitis (HP:0004469)4.77698081
11Abnormality of the nasal mucosa (HP:0000433)4.41758864
12Bronchiectasis (HP:0002110)4.34297795
13Recurrent abscess formation (HP:0002722)4.27184158
14Recurrent bacterial skin infections (HP:0005406)4.26761974
15Eczematoid dermatitis (HP:0000976)4.16993185
16Recurrent cutaneous fungal infections (HP:0011370)3.97488415
17Chronic mucocutaneous candidiasis (HP:0002728)3.97488415
18Recurrent gram-negative bacterial infections (HP:0005420)3.94997490
19Occipital encephalocele (HP:0002085)3.73680032
20Recurrent skin infections (HP:0001581)3.42898701
21Gingivitis (HP:0000230)3.38991279
22Periodontitis (HP:0000704)3.35654459
23Bronchitis (HP:0012387)3.23338803
24Recurrent sinusitis (HP:0011108)3.08992217
25Recurrent fungal infections (HP:0002841)2.99647151
26Systemic lupus erythematosus (HP:0002725)2.97543819
27Abnormality of calcium-phosphate metabolism (HP:0100530)2.97247900
28Male infertility (HP:0003251)2.84671103
29Keratoconjunctivitis (HP:0001096)2.79003634
30Infertility (HP:0000789)2.75269401
31Tubular atrophy (HP:0000092)2.69001717
32Chronic sinusitis (HP:0011109)2.66605721
33Nephronophthisis (HP:0000090)2.64494025
34Chronic otitis media (HP:0000389)2.55920138
35Pustule (HP:0200039)2.54410340
36Postaxial foot polydactyly (HP:0001830)2.54229003
37Dysostosis multiplex (HP:0000943)2.46770782
38Vacuolated lymphocytes (HP:0001922)2.41247929
39Stomatitis (HP:0010280)2.30957608
40Absent rod-and cone-mediated responses on ERG (HP:0007688)2.30156194
41Hyperactive renin-angiotensin system (HP:0000841)2.28740116
42Abnormality of macrophages (HP:0004311)2.26550025
43Short nail (HP:0001799)2.26469206
44Aplasia/Hypoplasia of the tongue (HP:0010295)2.26005396
45Atelectasis (HP:0100750)2.23522498
46Hypoplasia of dental enamel (HP:0006297)2.22465165
47Pancreatic fibrosis (HP:0100732)2.20901041
48Abnormality of midbrain morphology (HP:0002418)2.20620674
49Molar tooth sign on MRI (HP:0002419)2.20620674
50Recurrent bronchitis (HP:0002837)2.20432617
51Premature loss of primary teeth (HP:0006323)2.18504282
52Mediastinal lymphadenopathy (HP:0100721)2.16828634
53Anencephaly (HP:0002323)2.16661433
54Thick nail (HP:0001805)2.16130440
55Bell-shaped thorax (HP:0001591)2.15238857
56Abnormality of the renal medulla (HP:0100957)2.12292462
57Lip pit (HP:0100267)2.10503754
58Prostate neoplasm (HP:0100787)2.09218478
59Gastrointestinal infarctions (HP:0005244)2.08854619
60Tetraparesis (HP:0002273)2.04236161
61Glomerulonephritis (HP:0000099)2.04155157
62Abnormal delayed hypersensitivity skin test (HP:0002963)2.03837129
63Vasculitis (HP:0002633)2.02060938
64Elevated erythrocyte sedimentation rate (HP:0003565)1.98069250
65Recurrent otitis media (HP:0000403)1.97353293
66Aplasia/Hypoplasia of the spleen (HP:0010451)1.97031297
67Autoimmune thrombocytopenia (HP:0001973)1.96885843
68Increased IgM level (HP:0003496)1.95334026
69Cystic liver disease (HP:0006706)1.94768795
70Furrowed tongue (HP:0000221)1.94316307
71Urinary glycosaminoglycan excretion (HP:0003541)1.93858242
72Mucopolysacchariduria (HP:0008155)1.93858242
73Obstructive lung disease (HP:0006536)1.92859160
74Chronic obstructive pulmonary disease (HP:0006510)1.92859160
75Abnormality of the renal cortex (HP:0011035)1.92287263
76Congenital hepatic fibrosis (HP:0002612)1.90186980
77Hyperphosphatemia (HP:0002905)1.89035646
78Tubulointerstitial abnormality (HP:0001969)1.88712209
79Male pseudohermaphroditism (HP:0000037)1.88542367
80Decreased circulating renin level (HP:0003351)1.88186720
81Bile duct proliferation (HP:0001408)1.87589440
82Abnormal biliary tract physiology (HP:0012439)1.87589440
83True hermaphroditism (HP:0010459)1.87443368
84Medial flaring of the eyebrow (HP:0010747)1.87277052
85Oculomotor apraxia (HP:0000657)1.86491596
86Abnormality of dentin (HP:0010299)1.86317009
87Abnormality of mucopolysaccharide metabolism (HP:0011020)1.86112870
88Abnormality of polysaccharide metabolism (HP:0011012)1.86112870
89Abnormality of glycosaminoglycan metabolism (HP:0004371)1.86112870
90Congenital primary aphakia (HP:0007707)1.85027478
91Aplasia/Hypoplasia of the macula (HP:0008059)1.84030149
92Sclerocornea (HP:0000647)1.82307961
93Colitis (HP:0002583)1.81855179
94Median cleft lip (HP:0000161)1.80671379
95Gait imbalance (HP:0002141)1.79977867
96Chronic hepatic failure (HP:0100626)1.77378628
97Retrobulbar optic neuritis (HP:0100654)1.77227030
98Optic neuritis (HP:0100653)1.77227030
99Hyperkalemia (HP:0002153)1.76858606
100Asplenia (HP:0001746)1.76324323
101Tubulointerstitial nephritis (HP:0001970)1.75754731
102Abnormal drinking behavior (HP:0030082)1.75149670
103Polydipsia (HP:0001959)1.75149670
104Abnormality of proline metabolism (HP:0010907)1.73978844
105Hydroxyprolinuria (HP:0003080)1.73978844
106Interstitial pulmonary disease (HP:0006530)1.71510783
107J-shaped sella turcica (HP:0002680)1.71004476
108Myositis (HP:0100614)1.69691146
109Abnormal rod and cone electroretinograms (HP:0008323)1.67851068
110Orchitis (HP:0100796)1.66852493
111Loss of speech (HP:0002371)1.66137106
112Abnormality of the dental root (HP:0006486)1.65444608
113Taurodontia (HP:0000679)1.65444608
114Abnormality of permanent molar morphology (HP:0011071)1.65444608
115Aplasia/Hypoplasia affecting the retina (HP:0008061)1.65433314
116Nephrogenic diabetes insipidus (HP:0009806)1.65292835
117Postaxial hand polydactyly (HP:0001162)1.62780972
118Spondylolisthesis (HP:0003302)1.61192552
119Absent frontal sinuses (HP:0002688)1.58952164
120Tetany (HP:0001281)1.58876391
121Genetic anticipation (HP:0003743)1.58790593
122Hypergammaglobulinemia (HP:0010702)1.57932633
123Portal hypertension (HP:0001409)1.57418482
124Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.57234095
125Increased IgE level (HP:0003212)1.57063556
126Abnormality of the hepatic vasculature (HP:0006707)1.56691523
127Abnormality of the dental pulp (HP:0006479)1.56366152
128Pancreatic cysts (HP:0001737)1.56358222
129Recurrent pneumonia (HP:0006532)1.56236913
130Pathologic fracture (HP:0002756)1.55875883
131Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.55862940
132Gaze-evoked nystagmus (HP:0000640)1.51142634
133Cone-rod dystrophy (HP:0000548)1.50722511
134Bony spicule pigmentary retinopathy (HP:0007737)1.48237508
135Stage 5 chronic kidney disease (HP:0003774)1.48116114
136Nephropathy (HP:0000112)1.47272684
137Hyperventilation (HP:0002883)1.46737552
138Genital tract atresia (HP:0001827)1.46301461
139Preaxial hand polydactyly (HP:0001177)1.44525277
140Progressive cerebellar ataxia (HP:0002073)1.44152972
141Poor coordination (HP:0002370)1.43027561
142Vaginal atresia (HP:0000148)1.42982000
143Decreased central vision (HP:0007663)1.41814564
144Hyperaldosteronism (HP:0000859)1.36690147
145Renal salt wasting (HP:0000127)1.33110844
146Abnormality of chloride homeostasis (HP:0011422)1.29324225
147Tubulointerstitial fibrosis (HP:0005576)1.28995416
148Absent speech (HP:0001344)1.27930201
149Retinitis pigmentosa (HP:0000510)1.27780292
150Hypokalemic alkalosis (HP:0001949)1.24833084
151Highly arched eyebrow (HP:0002553)1.24058925
152Polyuria (HP:0000103)1.22739806
153Abnormality of renin-angiotensin system (HP:0000847)1.20310326
154Prominent nasal bridge (HP:0000426)1.15622215
155Intellectual disability, moderate (HP:0002342)1.15094263
156Glucose intolerance (HP:0000833)1.14581532
157Narrow forehead (HP:0000341)1.11270582
158Constricted visual fields (HP:0001133)1.10033735
159Abnormality of macular pigmentation (HP:0008002)1.10010810
160Short thorax (HP:0010306)1.08118373
161Supernumerary spleens (HP:0009799)1.07997167
162Dysmetric saccades (HP:0000641)1.07442971
163Central scotoma (HP:0000603)1.06439472
164Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.05046912
165Hypoplastic labia majora (HP:0000059)1.04618982

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.04109801
2MAPK153.75075461
3IRAK33.39517686
4IRAK43.05445002
5TAOK33.03206396
6RIPK42.65932771
7MST1R2.46348806
8TBK12.35955164
9LATS12.29616074
10EPHA32.27676849
11TYK22.21862194
12IKBKE2.19110745
13PDK32.18374124
14PDK42.18374124
15INSRR2.17137256
16ADRBK21.91641529
17JAK31.91355524
18PRKD31.89702207
19EPHB11.83722338
20JAK11.81986017
21IRAK11.80691400
22ACVR1B1.78354982
23MAP3K71.74731019
24IKBKB1.74671504
25STK38L1.71350733
26MAP4K21.66439686
27MAPKAPK31.64031626
28DAPK21.59765693
29CHUK1.49691073
30TRPM71.43698807
31MAP3K41.40547543
32MAP3K131.35346120
33CAMK1G1.29031823
34TESK11.27718350
35PDK21.27098541
36NEK61.25935612
37FGFR41.25825749
38NLK1.25650650
39OXSR11.25066251
40STK381.24806302
41PTK61.24613309
42MARK31.23505881
43PNCK1.19173252
44CAMK1D1.17798710
45CSK1.16019885
46DYRK31.15548395
47ICK1.10560723
48KIT1.08489688
49TXK1.05188498
50BMPR21.04669365
51NEK91.04569238
52HCK1.03979425
53MST41.02723626
54PTK2B1.02295441
55FER1.00813709
56BCR1.00743050
57DYRK1B0.98548718
58STK390.94258595
59HIPK20.91455925
60SGK20.91300469
61BLK0.90539059
62ERBB20.90391940
63PIK3CG0.90086187
64MAPK130.85763319
65MARK20.85508698
66JAK20.84657206
67CDC42BPA0.83359189
68NME10.81391142
69MET0.78996262
70AKT30.75711349
71TNK20.75137032
72FGFR30.74528775
73GRK60.73370165
74BRSK20.72330010
75BTK0.72250078
76STK240.71324446
77FES0.71162623
78ADRBK10.70662103
79EIF2AK20.70489713
80EGFR0.68822930
81LCK0.68443027
82SYK0.66135574
83FGR0.65961921
84EEF2K0.65649811
85BMPR1B0.65172321
86ZAP700.64741481
87ERN10.62897968
88ERBB30.62791147
89GRK50.62670973
90NUAK10.62410588
91PINK10.62299773
92WNK40.62037523
93PKN10.61837216
94PDK10.59779469
95IRAK20.58552053
96TEC0.57378841
97RPS6KA20.56085094
98MAP3K20.55890546
99PTK20.55736527
100TLK10.55691895
101NTRK10.54751088
102PRKAA20.53570275
103PBK0.53391520
104WNK30.52078593
105WNK10.51574354
106MELK0.51250477
107ITK0.50981896
108CDK190.50501310
109NTRK20.50456567
110ABL10.50063279
111PRKCI0.48837555
112RIPK10.48393585
113FRK0.48182538
114MAP2K20.47958982
115CAMK40.46174121
116TGFBR20.46062283
117STK110.45163363
118SIK20.45107667
119STK100.45057231
120SGK4940.44358913
121SGK2230.44358913
122PAK30.43704620
123EPHA20.43591064
124STK30.43440189
125GSK3A0.43186705
126PRKCE0.42432125
127DYRK1A0.41281012
128BRD40.41146029
129GRK70.41133895
130YES10.41126828
131MAP3K30.41098610
132PDPK10.40871021
133LYN0.40382439
134MAP4K10.40275888
135IGF1R0.39889534
136PRKCQ0.39733135
137SGK10.38548594
138SGK30.38325430
139PRKCD0.37208780
140CDK120.34392347
141MAP2K10.33980224
142MATK0.33584941
143MAP3K10.31060554
144INSR0.30921567
145CAMKK10.30906277
146GRK10.30380086
147MKNK20.28846570
148PRKAA10.28097427
149CDK90.27534691
150TTK0.27443138
151RPS6KB20.26591333
152MUSK0.26373788
153NTRK30.26296335
154PLK40.25963781

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.67036176
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.62819156
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.39918753
4Chemical carcinogenesis_Homo sapiens_hsa052043.24188529
5Leishmaniasis_Homo sapiens_hsa051402.72954317
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.50841057
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.38744422
8Pertussis_Homo sapiens_hsa051332.35104369
9Allograft rejection_Homo sapiens_hsa053302.32624792
10Other glycan degradation_Homo sapiens_hsa005112.25804348
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.21836168
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.15693325
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.14664761
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.07008859
15Osteoclast differentiation_Homo sapiens_hsa043802.02076274
16Malaria_Homo sapiens_hsa051442.00387954
17Legionellosis_Homo sapiens_hsa051342.00083463
18Tyrosine metabolism_Homo sapiens_hsa003501.97019615
19Type I diabetes mellitus_Homo sapiens_hsa049401.96987808
20beta-Alanine metabolism_Homo sapiens_hsa004101.95726150
21Retinol metabolism_Homo sapiens_hsa008301.85220894
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.80224874
23African trypanosomiasis_Homo sapiens_hsa051431.77159710
24Graft-versus-host disease_Homo sapiens_hsa053321.76511852
25Asthma_Homo sapiens_hsa053101.71786016
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.70974743
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.69121537
28Rheumatoid arthritis_Homo sapiens_hsa053231.68343994
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.68246556
30Measles_Homo sapiens_hsa051621.66236996
31Antigen processing and presentation_Homo sapiens_hsa046121.65147694
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.60692196
33Tuberculosis_Homo sapiens_hsa051521.56850708
34Linoleic acid metabolism_Homo sapiens_hsa005911.55289055
35Influenza A_Homo sapiens_hsa051641.48686052
36Lysosome_Homo sapiens_hsa041421.47409416
37TNF signaling pathway_Homo sapiens_hsa046681.47073904
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46839417
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44872415
40Toxoplasmosis_Homo sapiens_hsa051451.42665119
41Phototransduction_Homo sapiens_hsa047441.31942538
42Huntingtons disease_Homo sapiens_hsa050161.30787725
43Phagosome_Homo sapiens_hsa041451.30593133
44Salivary secretion_Homo sapiens_hsa049701.28233287
45Histidine metabolism_Homo sapiens_hsa003401.28063944
46Primary immunodeficiency_Homo sapiens_hsa053401.27270168
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.26961560
48Caffeine metabolism_Homo sapiens_hsa002321.25735549
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25361279
50Complement and coagulation cascades_Homo sapiens_hsa046101.24801493
51Carbohydrate digestion and absorption_Homo sapiens_hsa049731.16239483
52Dorso-ventral axis formation_Homo sapiens_hsa043201.14511400
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13913526
54Type II diabetes mellitus_Homo sapiens_hsa049301.13120923
55Arachidonic acid metabolism_Homo sapiens_hsa005901.11088136
56B cell receptor signaling pathway_Homo sapiens_hsa046621.09338479
57Prion diseases_Homo sapiens_hsa050201.09186376
58Herpes simplex infection_Homo sapiens_hsa051681.09088678
59Glutathione metabolism_Homo sapiens_hsa004801.08126523
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06901897
61Chemokine signaling pathway_Homo sapiens_hsa040621.06363699
62Circadian rhythm_Homo sapiens_hsa047101.05483389
63ABC transporters_Homo sapiens_hsa020101.03248960
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03117546
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01370134
66Sphingolipid metabolism_Homo sapiens_hsa006001.01125722
67Fatty acid degradation_Homo sapiens_hsa000710.99277631
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.99020075
69Tryptophan metabolism_Homo sapiens_hsa003800.97018984
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96934151
71Nicotine addiction_Homo sapiens_hsa050330.96367497
72Autoimmune thyroid disease_Homo sapiens_hsa053200.93607675
73Amoebiasis_Homo sapiens_hsa051460.92357723
74Nitrogen metabolism_Homo sapiens_hsa009100.92333707
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91603961
76Systemic lupus erythematosus_Homo sapiens_hsa053220.88880532
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87670002
78Choline metabolism in cancer_Homo sapiens_hsa052310.86432820
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84756298
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82847112
81Hematopoietic cell lineage_Homo sapiens_hsa046400.82026889
82Salmonella infection_Homo sapiens_hsa051320.78837654
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78492849
84Ether lipid metabolism_Homo sapiens_hsa005650.77688976
85Butanoate metabolism_Homo sapiens_hsa006500.75800167
86Tight junction_Homo sapiens_hsa045300.74663016
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73498593
88Apoptosis_Homo sapiens_hsa042100.72409110
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71000336
90Glycerolipid metabolism_Homo sapiens_hsa005610.69607702
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69472535
92Peroxisome_Homo sapiens_hsa041460.68765533
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.67837104
94Hepatitis C_Homo sapiens_hsa051600.67207162
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66803192
96cAMP signaling pathway_Homo sapiens_hsa040240.66772688
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66577444
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66295145
99Ovarian steroidogenesis_Homo sapiens_hsa049130.64259279
100Hedgehog signaling pathway_Homo sapiens_hsa043400.63746569
101Prolactin signaling pathway_Homo sapiens_hsa049170.61498749
102Inositol phosphate metabolism_Homo sapiens_hsa005620.60557513
103Serotonergic synapse_Homo sapiens_hsa047260.59676107
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59282932
105Starch and sucrose metabolism_Homo sapiens_hsa005000.56934012
106Insulin resistance_Homo sapiens_hsa049310.55773457
107Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55063122
108Insulin secretion_Homo sapiens_hsa049110.54005629
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52479437
110Hepatitis B_Homo sapiens_hsa051610.52197223
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.51777778
112Collecting duct acid secretion_Homo sapiens_hsa049660.51455489
113Olfactory transduction_Homo sapiens_hsa047400.51420579
114Protein export_Homo sapiens_hsa030600.50830495
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50450381
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.49992034
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49222435
118Platelet activation_Homo sapiens_hsa046110.48679474
119Lysine degradation_Homo sapiens_hsa003100.47181184
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47102599
121Glutamatergic synapse_Homo sapiens_hsa047240.44520313
122Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41073707
123PPAR signaling pathway_Homo sapiens_hsa033200.40266418
124T cell receptor signaling pathway_Homo sapiens_hsa046600.39876982
125Propanoate metabolism_Homo sapiens_hsa006400.39283958
126Morphine addiction_Homo sapiens_hsa050320.38210488
127Fatty acid biosynthesis_Homo sapiens_hsa000610.37738503
128Renin secretion_Homo sapiens_hsa049240.36382428
129Glucagon signaling pathway_Homo sapiens_hsa049220.34829329
130Alcoholism_Homo sapiens_hsa050340.34562522
131Selenocompound metabolism_Homo sapiens_hsa004500.34551600
132Mineral absorption_Homo sapiens_hsa049780.33947129
133Adherens junction_Homo sapiens_hsa045200.33291613
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.32746279
135Small cell lung cancer_Homo sapiens_hsa052220.32589273
136mTOR signaling pathway_Homo sapiens_hsa041500.32205764
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30743940
138Acute myeloid leukemia_Homo sapiens_hsa052210.30614140
139Regulation of autophagy_Homo sapiens_hsa041400.30046125
140Pancreatic secretion_Homo sapiens_hsa049720.29888891
141Basal cell carcinoma_Homo sapiens_hsa052170.29564946
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.29513267
143Circadian entrainment_Homo sapiens_hsa047130.29154823
144Phenylalanine metabolism_Homo sapiens_hsa003600.28612901
145Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28504101
146FoxO signaling pathway_Homo sapiens_hsa040680.27783058
147Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27776185
148Vitamin digestion and absorption_Homo sapiens_hsa049770.26998749
149Sulfur metabolism_Homo sapiens_hsa009200.26860999
150MAPK signaling pathway_Homo sapiens_hsa040100.22264242
151Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.19641942
152Taste transduction_Homo sapiens_hsa047420.19131900
153Chronic myeloid leukemia_Homo sapiens_hsa052200.18025837
154Calcium signaling pathway_Homo sapiens_hsa040200.17664949
155Viral myocarditis_Homo sapiens_hsa054160.17092587
156Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16081262

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