ADGRA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)6.38765664
2collagen fibril organization (GO:0030199)5.81811282
3bone trabecula formation (GO:0060346)5.67753054
4chondrocyte proliferation (GO:0035988)5.64630171
5axon extension involved in axon guidance (GO:0048846)5.17659294
6neuron projection extension involved in neuron projection guidance (GO:1902284)5.17659294
7endodermal cell differentiation (GO:0035987)4.87473742
8sequestering of extracellular ligand from receptor (GO:0035581)4.59151328
9skin morphogenesis (GO:0043589)4.56992618
10collagen metabolic process (GO:0032963)4.39720082
11basement membrane organization (GO:0071711)4.35367803
12collagen catabolic process (GO:0030574)4.34189400
13polarized epithelial cell differentiation (GO:0030859)4.23232467
14planar cell polarity pathway involved in neural tube closure (GO:0090179)4.18532749
15multicellular organismal macromolecule metabolic process (GO:0044259)4.12849045
16type B pancreatic cell proliferation (GO:0044342)4.11900656
17regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.02585556
18negative regulation of fatty acid transport (GO:2000192)4.02086178
19plasma membrane repair (GO:0001778)4.00839666
20multicellular organismal catabolic process (GO:0044243)3.98672797
21multicellular organismal metabolic process (GO:0044236)3.88052633
22outer ear morphogenesis (GO:0042473)3.87590416
23regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.87433860
24insulin-like growth factor receptor signaling pathway (GO:0048009)3.84040933
25hippo signaling (GO:0035329)3.80143228
26adhesion of symbiont to host cell (GO:0044650)3.78759577
27virion attachment to host cell (GO:0019062)3.78759577
28mesenchymal-epithelial cell signaling (GO:0060638)3.78447802
29metanephric mesenchyme development (GO:0072075)3.75898728
30extracellular matrix disassembly (GO:0022617)3.74485365
31cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.68926796
32craniofacial suture morphogenesis (GO:0097094)3.67255253
33kidney mesenchyme development (GO:0072074)3.61873128
34cell migration involved in sprouting angiogenesis (GO:0002042)3.61572947
35negative regulation of chondrocyte differentiation (GO:0032331)3.61147357
36vascular endothelial growth factor signaling pathway (GO:0038084)3.61142766
37G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.55829180
38cell proliferation involved in metanephros development (GO:0072203)3.53839540
39paraxial mesoderm development (GO:0048339)3.51069599
40tooth mineralization (GO:0034505)3.49457728
41keratan sulfate catabolic process (GO:0042340)3.45482011
42peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.43130291
43dermatan sulfate metabolic process (GO:0030205)3.42178072
44endocardial cushion development (GO:0003197)3.40973956
45retina vasculature morphogenesis in camera-type eye (GO:0061299)3.39418330
46positive regulation of endothelial cell apoptotic process (GO:2000353)3.39066211
47cell adhesion mediated by integrin (GO:0033627)3.36908319
48adhesion of symbiont to host (GO:0044406)3.32936457
49wound healing, spreading of epidermal cells (GO:0035313)3.25429338
50cell migration involved in heart development (GO:0060973)3.25161269
51blood vessel maturation (GO:0001955)3.20515049
52embryonic cranial skeleton morphogenesis (GO:0048701)3.19460875
53cardiac myofibril assembly (GO:0055003)3.19314470
54trabecula formation (GO:0060343)3.17497414
55negative regulation of catenin import into nucleus (GO:0035414)3.15865600
56glomerular basement membrane development (GO:0032836)3.15594506
57barbed-end actin filament capping (GO:0051016)3.14867755
58positive regulation of epithelial to mesenchymal transition (GO:0010718)3.12253704
59vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.09554597
60regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.08606725
61renal filtration (GO:0097205)3.08439117
62glomerular filtration (GO:0003094)3.07339115
63middle ear morphogenesis (GO:0042474)3.04083245
64epithelial cell-cell adhesion (GO:0090136)3.03722019
65negative regulation of cartilage development (GO:0061037)3.02120354
66blood vessel endothelial cell migration (GO:0043534)3.02044485
67lymph vessel development (GO:0001945)3.01328324
68cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.98001599
69anatomical structure regression (GO:0060033)2.97746705
70apoptotic cell clearance (GO:0043277)2.97203806
71stress fiber assembly (GO:0043149)2.97075774
72positive regulation of blood vessel endothelial cell migration (GO:0043536)2.97074614
73positive regulation of mesenchymal cell proliferation (GO:0002053)2.96814164
74cellular response to vitamin (GO:0071295)2.96463350
75extracellular fibril organization (GO:0043206)2.96034710
76positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.94990263
77Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.93516133
78venous blood vessel morphogenesis (GO:0048845)2.92989729
79adherens junction assembly (GO:0034333)2.91575245
80regulation of establishment of planar polarity (GO:0090175)2.89244651
81substrate adhesion-dependent cell spreading (GO:0034446)2.89062932
82protein localization to cell surface (GO:0034394)2.88877721
83establishment of apical/basal cell polarity (GO:0035089)2.87050460
84dermatan sulfate biosynthetic process (GO:0030208)2.87027465
85chondrocyte development (GO:0002063)2.86690905
86endothelial cell morphogenesis (GO:0001886)2.85654945
87branching involved in salivary gland morphogenesis (GO:0060445)2.85566870
88negative regulation of embryonic development (GO:0045992)2.85376976
89smooth muscle tissue development (GO:0048745)2.84983227
90regulation of extracellular matrix disassembly (GO:0010715)2.82118783
91atrioventricular valve morphogenesis (GO:0003181)2.81511144
92regulation of heart morphogenesis (GO:2000826)2.81254082
93artery morphogenesis (GO:0048844)2.73853056
94positive regulation of glycogen biosynthetic process (GO:0045725)2.73820587
95heart morphogenesis (GO:0003007)2.73630190
96cell proliferation involved in kidney development (GO:0072111)2.73590832
97regulation of cartilage development (GO:0061035)2.72470138
98glial cell migration (GO:0008347)2.72308499
99positive regulation of fibroblast migration (GO:0010763)2.72292291
100cellular response to amino acid stimulus (GO:0071230)2.72135466
101cell-substrate junction assembly (GO:0007044)2.70399828
102negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.69724674
103mesenchyme development (GO:0060485)2.69554181
104semaphorin-plexin signaling pathway (GO:0071526)2.68930837
105regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.68891166
106cell-substrate adherens junction assembly (GO:0007045)2.68533114
107focal adhesion assembly (GO:0048041)2.68533114
108midgut development (GO:0007494)2.68356117
109regulation of mesenchymal cell proliferation (GO:0010464)2.66161719
110embryonic skeletal joint morphogenesis (GO:0060272)2.65953518
111extracellular matrix organization (GO:0030198)2.65942898
112extracellular regulation of signal transduction (GO:1900115)2.65180245
113extracellular negative regulation of signal transduction (GO:1900116)2.65180245
114extracellular structure organization (GO:0043062)2.64785126
115substrate-dependent cell migration (GO:0006929)2.64419942
116negative regulation of smooth muscle cell migration (GO:0014912)2.64331319
117eye morphogenesis (GO:0048592)2.63902192
118lymphangiogenesis (GO:0001946)2.63673614
119regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.62405239
120mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.62165523
121regulation of chondrocyte differentiation (GO:0032330)2.62132879
122positive regulation of receptor recycling (GO:0001921)2.61583478
123non-canonical Wnt signaling pathway (GO:0035567)2.60539406
124hyaluronan catabolic process (GO:0030214)2.60404503
125fibril organization (GO:0097435)2.59551547
126extracellular matrix assembly (GO:0085029)2.58390579
127lung-associated mesenchyme development (GO:0060484)2.57852076
128aorta morphogenesis (GO:0035909)2.57127279
129chondroitin sulfate catabolic process (GO:0030207)2.54865191
130negative regulation of BMP signaling pathway (GO:0030514)2.54786065
131response to fluid shear stress (GO:0034405)2.53945045
132chondroitin sulfate biosynthetic process (GO:0030206)2.52819982
133protein retention in ER lumen (GO:0006621)2.51605871
134cochlea morphogenesis (GO:0090103)2.49169016
135Golgi transport vesicle coating (GO:0048200)2.47579592
136COPI coating of Golgi vesicle (GO:0048205)2.47579592

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.76795179
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.67221973
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.16601861
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.16452934
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.13617292
6CLOCK_20551151_ChIP-Seq_293T_Human2.98825500
7RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.73531625
8EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.72128376
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.70859207
10TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.61936993
11WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.54700051
12ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.40404734
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.34947178
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.23506459
15WT1_19549856_ChIP-ChIP_CCG9911_Human2.23496722
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.19818886
17EP300_21415370_ChIP-Seq_HL-1_Mouse2.16608400
18CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.00456544
19CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.97402171
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.97212244
21BRD4_25478319_ChIP-Seq_HGPS_Human1.92258940
22ZFP281_18757296_ChIP-ChIP_E14_Mouse1.90255083
23HIF1A_21447827_ChIP-Seq_MCF-7_Human1.85244888
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.82433370
25CJUN_26792858_Chip-Seq_BT549_Human1.79182355
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.78205233
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.77511557
28DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.76944188
29TP53_20018659_ChIP-ChIP_R1E_Mouse1.76707238
30P300_27058665_Chip-Seq_ZR-75-30cells_Human1.75775497
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.74573619
32ZFP281_27345836_Chip-Seq_ESCs_Mouse1.64016726
33RNF2_18974828_ChIP-Seq_MESCs_Mouse1.63229210
34EZH2_18974828_ChIP-Seq_MESCs_Mouse1.63229210
35ISL1_27105846_Chip-Seq_CPCs_Mouse1.59619218
36NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.52039570
37HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.51482014
38TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.50759102
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.49411359
40MTF2_20144788_ChIP-Seq_MESCs_Mouse1.49323739
41KDM2B_26808549_Chip-Seq_K562_Human1.46810708
42SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.45352327
43TBX20_22328084_ChIP-Seq_HEART_Mouse1.44497765
44TBX20_22080862_ChIP-Seq_HEART_Mouse1.44497765
45KDM2B_26808549_Chip-Seq_DND41_Human1.44432070
46KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44060369
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43731412
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.42992025
49SMC1_22415368_ChIP-Seq_MEFs_Mouse1.41711191
50NFIB_24661679_ChIP-Seq_LUNG_Mouse1.40810712
51UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.40106511
52UBF1/2_26484160_Chip-Seq_HMECs_Human1.39817421
53TP53_22127205_ChIP-Seq_IMR90_Human1.39763191
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.39054557
55LXR_22292898_ChIP-Seq_THP-1_Human1.37170128
56ATF3_27146783_Chip-Seq_COLON_Human1.36886326
57RACK7_27058665_Chip-Seq_MCF-7_Human1.36695089
58PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.36308067
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35368814
60PPAR_26484153_Chip-Seq_NCI-H1993_Human1.34985178
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33082918
62SA1_22415368_ChIP-Seq_MEFs_Mouse1.32946409
63KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32400224
64EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32191120
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.31121460
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31030838
67SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.30406228
68SOX9_24532713_ChIP-Seq_HFSC_Mouse1.29440602
69SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.28133697
70SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.28133697
71TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26284297
72ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.25208230
73TP53_23651856_ChIP-Seq_MEFs_Mouse1.24813989
74SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.24728613
75ESR1_21235772_ChIP-Seq_MCF-7_Human1.23611433
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.22797247
77SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.22408760
78NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22102964
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22102964
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20780368
81JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19525149
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19241799
83WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18299517
84SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.17255851
85MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.17141629
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16010192
87FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.15992540
88TP53_16413492_ChIP-PET_HCT116_Human1.15433428
89ZNF263_19887448_ChIP-Seq_K562_Human1.15209229
90DROSHA_22980978_ChIP-Seq_HELA_Human1.14845224
91JARID2_20075857_ChIP-Seq_MESCs_Mouse1.13174484
92SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13030998
93SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12605838
94SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12371294
95TP53_18474530_ChIP-ChIP_U2OS_Human1.12356502
96EZH2_27294783_Chip-Seq_ESCs_Mouse1.11270049
97SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09775472
98FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.09642233
99SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08761517
100EZH2_27304074_Chip-Seq_ESCs_Mouse1.08427579
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05491020
102TET1_21490601_ChIP-Seq_MESCs_Mouse1.05354594
103SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02992585
104NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02961488
105SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02397443
106RING1B_27294783_Chip-Seq_ESCs_Mouse1.02226147
107EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02053640
108FOXM1_23109430_ChIP-Seq_U2OS_Human1.02013310
109JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01632988
110ESR1_20079471_ChIP-ChIP_T-47D_Human1.01110980
111ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00959516
112ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00855016
113DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00598932
114TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00382907
115FOXO3_23340844_ChIP-Seq_DLD1_Human1.00222416
116SMC3_22415368_ChIP-Seq_MEFs_Mouse0.99604219
117ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99094222
118RNF2_27304074_Chip-Seq_ESCs_Mouse0.98577623
119CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98318012
120TCF7_22412390_ChIP-Seq_EML_Mouse0.97986986
121NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97238650
122VDR_21846776_ChIP-Seq_THP-1_Human0.94210838
123CTCF_27219007_Chip-Seq_Bcells_Human0.92346239
124PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91835863

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.97196733
2MP0005503_abnormal_tendon_morphology4.29435868
3MP0005275_abnormal_skin_tensile4.19055268
4MP0003705_abnormal_hypodermis_morpholog4.15158561
5MP0004272_abnormal_basement_membrane3.71495813
6MP0005623_abnormal_meninges_morphology3.33519648
7MP0003279_aneurysm3.30099873
8MP0001958_emphysema2.67979913
9MP0006054_spinal_hemorrhage2.51928551
10MP0010030_abnormal_orbit_morphology2.47115150
11MP0003385_abnormal_body_wall2.26406364
12MP0010368_abnormal_lymphatic_system2.18874663
13MP0005257_abnormal_intraocular_pressure2.08170425
14MP0003122_maternal_imprinting1.99734025
15MP0005508_abnormal_skeleton_morphology1.98812584
16MP0009384_cardiac_valve_regurgitation1.95856047
17MP0003566_abnormal_cell_adhesion1.86545281
18MP0009250_abnormal_appendicular_skeleto1.85282228
19MP0000733_abnormal_muscle_development1.83555168
20MP0009053_abnormal_anal_canal1.81228026
21MP0003283_abnormal_digestive_organ1.80207291
22MP0000534_abnormal_ureter_morphology1.75323655
23MP0002060_abnormal_skin_morphology1.67249795
24MP0003942_abnormal_urinary_system1.64256061
25MP0010352_gastrointestinal_tract_polyps1.63051341
26MP0003091_abnormal_cell_migration1.59268668
27MP0002896_abnormal_bone_mineralization1.59007101
28MP0000428_abnormal_craniofacial_morphol1.57954602
29MP0002108_abnormal_muscle_morphology1.57086097
30MP0000751_myopathy1.54093893
31MP0000537_abnormal_urethra_morphology1.50798414
32MP0000767_abnormal_smooth_muscle1.48998184
33MP0004858_abnormal_nervous_system1.46967574
34MP0005023_abnormal_wound_healing1.45820292
35MP0003115_abnormal_respiratory_system1.43529904
36MP0002932_abnormal_joint_morphology1.42235650
37MP0001299_abnormal_eye_distance/1.42223749
38MP0001243_abnormal_dermal_layer1.35472004
39MP0005076_abnormal_cell_differentiation1.33562167
40MP0000049_abnormal_middle_ear1.30350532
41MP0002282_abnormal_trachea_morphology1.28218975
42MP0002295_abnormal_pulmonary_circulatio1.25350250
43MP0004084_abnormal_cardiac_muscle1.23035294
44MP0002249_abnormal_larynx_morphology1.22459097
45MP0003755_abnormal_palate_morphology1.20137080
46MP0003935_abnormal_craniofacial_develop1.18970851
47MP0003941_abnormal_skin_development1.18750662
48MP0000013_abnormal_adipose_tissue1.18486112
49MP0001879_abnormal_lymphatic_vessel1.17452225
50MP0004134_abnormal_chest_morphology1.15278096
51MP0002933_joint_inflammation1.15256008
52MP0002115_abnormal_skeleton_extremities1.12375928
53MP0003123_paternal_imprinting1.11732781
54MP0000163_abnormal_cartilage_morphology1.10418067
55MP0003937_abnormal_limbs/digits/tail_de1.07487363
56MP0005409_darkened_coat_color1.07104110
57MP0000750_abnormal_muscle_regeneration1.06931922
58MP0005171_absent_coat_pigmentation1.02440208
59MP0001348_abnormal_lacrimal_gland1.00171643
60MP0003567_abnormal_fetal_cardiomyocyte0.99663749
61MP0002128_abnormal_blood_circulation0.98933592
62MP0002089_abnormal_postnatal_growth/wei0.98810223
63MP0002925_abnormal_cardiovascular_devel0.98735008
64MP0003045_fibrosis0.98561742
65MP0002116_abnormal_craniofacial_bone0.98255259
66MP0006138_congestive_heart_failure0.97391120
67MP0002877_abnormal_melanocyte_morpholog0.95357029
68MP0002113_abnormal_skeleton_development0.95277813
69MP0000432_abnormal_head_morphology0.94760587
70MP0001614_abnormal_blood_vessel0.93912486
71MP0004087_abnormal_muscle_fiber0.93639185
72MP0004197_abnormal_fetal_growth/weight/0.93405249
73MP0009780_abnormal_chondrocyte_physiolo0.92752358
74MP0002109_abnormal_limb_morphology0.92556899
75MP0004233_abnormal_muscle_weight0.91602672
76MP0005058_abnormal_lysosome_morphology0.91245070
77MP0000003_abnormal_adipose_tissue0.90279487
78MP0002168_other_aberrant_phenotype0.90165533
79MP0002233_abnormal_nose_morphology0.89563687
80MP0010630_abnormal_cardiac_muscle0.87090480
81MP0003300_gastrointestinal_ulcer0.86826188
82MP0001915_intracranial_hemorrhage0.86672568
83MP0005390_skeleton_phenotype0.85988912
84MP0001849_ear_inflammation0.85509902
85MP0001542_abnormal_bone_strength0.85493656
86MP0000762_abnormal_tongue_morphology0.84445442
87MP0002697_abnormal_eye_size0.83643724
88MP0003950_abnormal_plasma_membrane0.83363414
89MP0002111_abnormal_tail_morphology0.82665707
90MP0002133_abnormal_respiratory_system0.82488981
91MP0005388_respiratory_system_phenotype0.82488981
92MP0005164_abnormal_response_to0.82050116
93MP0000759_abnormal_skeletal_muscle0.81731951
94MP0000462_abnormal_digestive_system0.79926151
95MP0002114_abnormal_axial_skeleton0.77362894
96MP0000266_abnormal_heart_morphology0.76380124
97MP0003828_pulmonary_edema0.76104383
98MP0001175_abnormal_lung_morphology0.73505266
99MP0009278_abnormal_bone_marrow0.73477213
100MP0005670_abnormal_white_adipose0.71087980
101MP0005330_cardiomyopathy0.71024778
102MP0003448_altered_tumor_morphology0.70892353
103MP0002092_abnormal_eye_morphology0.69387949
104MP0000516_abnormal_urinary_system0.69382531
105MP0005367_renal/urinary_system_phenotyp0.69382531
106MP0004145_abnormal_muscle_electrophysio0.68805111
107MP0001533_abnormal_skeleton_physiology0.68281705
108MP0003795_abnormal_bone_structure0.68065280
109MP0005369_muscle_phenotype0.66460960
110MP0010386_abnormal_urinary_bladder0.66237886
111MP0005197_abnormal_uvea_morphology0.65853418
112MP0005375_adipose_tissue_phenotype0.65354142
113MP0002938_white_spotting0.64837623
114MP0005385_cardiovascular_system_phenoty0.64330520
115MP0001544_abnormal_cardiovascular_syste0.64330520
116MP0002127_abnormal_cardiovascular_syste0.63697997
117MP0005595_abnormal_vascular_smooth0.63679500
118MP0002998_abnormal_bone_remodeling0.63602290
119MP0001340_abnormal_eyelid_morphology0.63548137
120MP0002254_reproductive_system_inflammat0.63491870
121MP0005248_abnormal_Harderian_gland0.63439687
122MP0004036_abnormal_muscle_relaxation0.60733286
123MP0008004_abnormal_stomach_pH0.58418404
124MP0000249_abnormal_blood_vessel0.57444718
125MP0005620_abnormal_muscle_contractility0.54019179
126MP0000538_abnormal_urinary_bladder0.53973296
127MP0001270_distended_abdomen0.53581614
128MP0000749_muscle_degeneration0.52889504

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.79575234
2Premature rupture of membranes (HP:0001788)6.99107790
3Ankle contracture (HP:0006466)5.43254081
4Shallow orbits (HP:0000586)5.16930122
5Broad metatarsal (HP:0001783)4.57853380
6Aortic dissection (HP:0002647)4.41690812
7Cerebral aneurysm (HP:0004944)4.09386613
8Atrophic scars (HP:0001075)4.06845071
9Peritonitis (HP:0002586)4.02643965
10Bladder diverticulum (HP:0000015)3.93333528
11Type 1 muscle fiber predominance (HP:0003803)3.82822881
12Soft skin (HP:0000977)3.80358546
13Abnormality of dentin (HP:0010299)3.65887688
14Fragile skin (HP:0001030)3.64953511
15Follicular hyperkeratosis (HP:0007502)3.57614075
16Mitral valve prolapse (HP:0001634)3.51692930
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.51442872
18Short 4th metacarpal (HP:0010044)3.51442872
19Dilatation of the ascending aorta (HP:0005111)3.45507233
20Neonatal short-limb short stature (HP:0008921)3.35899627
21Cervical subluxation (HP:0003308)3.31898466
22Spinal rigidity (HP:0003306)3.19019555
23Wrist flexion contracture (HP:0001239)3.18681982
24Aortic aneurysm (HP:0004942)3.18337661
25Genu recurvatum (HP:0002816)3.17969766
26Increased connective tissue (HP:0009025)3.13409077
27Slender build (HP:0001533)2.97645643
28Blue sclerae (HP:0000592)2.97147867
29Spondylolisthesis (HP:0003302)2.91544974
30Wormian bones (HP:0002645)2.87821800
31Bowel diverticulosis (HP:0005222)2.83980728
32Abnormality of the 4th metacarpal (HP:0010012)2.82169114
33Aortic regurgitation (HP:0001659)2.79514172
34Mildly elevated creatine phosphokinase (HP:0008180)2.78423469
35Increased variability in muscle fiber diameter (HP:0003557)2.71463737
36Biconcave vertebral bodies (HP:0004586)2.70955608
37Asymmetry of the thorax (HP:0001555)2.68579245
38Deviation of the hallux (HP:0010051)2.66829226
39Hallux valgus (HP:0001822)2.54647171
40Wide anterior fontanel (HP:0000260)2.50348778
41Hyperextensible skin (HP:0000974)2.49800242
42Buphthalmos (HP:0000557)2.45343811
43Vertebral compression fractures (HP:0002953)2.42454669
44Elbow flexion contracture (HP:0002987)2.39747446
45Camptodactyly of toe (HP:0001836)2.38944949
46Ulnar bowing (HP:0003031)2.37444671
47Aneurysm (HP:0002617)2.37039082
48Joint laxity (HP:0001388)2.36600138
49Joint stiffness (HP:0001387)2.34878778
50Mild short stature (HP:0003502)2.34812985
51Thin bony cortex (HP:0002753)2.33452873
52Abnormality of skeletal muscle fiber size (HP:0012084)2.33183527
53Aortic valve stenosis (HP:0001650)2.31995962
54Coronal craniosynostosis (HP:0004440)2.31118477
55Renal duplication (HP:0000075)2.29363053
56Round ear (HP:0100830)2.28246955
57Infantile muscular hypotonia (HP:0008947)2.26529174
58Mesomelia (HP:0003027)2.25437766
59Ectopia lentis (HP:0001083)2.21539542
60Abnormal delivery (HP:0001787)2.19819379
61Mitral regurgitation (HP:0001653)2.19076642
62Abnormality of the peritoneum (HP:0002585)2.17651621
63Overgrowth (HP:0001548)2.16461091
64Lymphangioma (HP:0100764)2.16090355
65Abnormality of the acetabulum (HP:0003170)2.14537194
66Nonimmune hydrops fetalis (HP:0001790)2.12318614
67Morphological abnormality of the middle ear (HP:0008609)2.07137861
68Broad long bones (HP:0005622)2.06246893
69Spinal cord lesions (HP:0100561)2.05221863
70Syringomyelia (HP:0003396)2.05221863
71Vascular tortuosity (HP:0004948)2.04384814
72Broad ribs (HP:0000885)2.03699418
73Obstructive sleep apnea (HP:0002870)2.03417288
74Turricephaly (HP:0000262)2.00828231
75Knee flexion contracture (HP:0006380)1.99586457
76Protruding ear (HP:0000411)1.98659505
77Disproportionate tall stature (HP:0001519)1.95424299
78Hip contracture (HP:0003273)1.95119861
79Pulmonary artery stenosis (HP:0004415)1.93722418
80Generalized amyotrophy (HP:0003700)1.93288799
81Hypoplasia of the iris (HP:0007676)1.91756112
82Striae distensae (HP:0001065)1.91380217
83Venous abnormality (HP:0002624)1.90035386
84Bell-shaped thorax (HP:0001591)1.89968950
85Tibial bowing (HP:0002982)1.89785729
86Joint contractures involving the joints of the feet (HP:0100492)1.89754739
87Flexion contracture of toe (HP:0005830)1.89754739
88Long toe (HP:0010511)1.89636886
89Emphysema (HP:0002097)1.89222582
90Hypoventilation (HP:0002791)1.89133397
91Venous insufficiency (HP:0005293)1.89082291
92Delayed cranial suture closure (HP:0000270)1.88468465
93Osteolytic defects of the phalanges of the hand (HP:0009771)1.87940878
94Osteolytic defects of the hand bones (HP:0009699)1.87940878
95Renovascular hypertension (HP:0100817)1.87927288
96Premature skin wrinkling (HP:0100678)1.87155408
97Persistence of primary teeth (HP:0006335)1.86393887
98Flat cornea (HP:0007720)1.85368178
99Abnormality of skull ossification (HP:0002703)1.84729403
100Enlarged penis (HP:0000040)1.84315389
101Breech presentation (HP:0001623)1.84280182
102Bowed forearm bones (HP:0003956)1.82455112
103Bowing of the arm (HP:0006488)1.82455112
104Natal tooth (HP:0000695)1.82346642
105Scapular winging (HP:0003691)1.77401530
106Congenital glaucoma (HP:0001087)1.76136567
107Arterial tortuosity (HP:0005116)1.75880773
108Calcaneovalgus deformity (HP:0001848)1.75681906
109Femoral bowing (HP:0002980)1.75189332
110Muscle fiber splitting (HP:0003555)1.75166537
111Osteoarthritis (HP:0002758)1.74793415
112Broad toe (HP:0001837)1.74018120
113Hyperacusis (HP:0010780)1.73956268
114Abnormality of the parietal bone (HP:0002696)1.72292339
115Deformed tarsal bones (HP:0008119)1.72059900
116Slender long bone (HP:0003100)1.70756522
117Difficulty climbing stairs (HP:0003551)1.70173434
118Inguinal hernia (HP:0000023)1.69969256
119Delayed closure of the anterior fontanelle (HP:0001476)1.69837282
120Limited hip movement (HP:0008800)1.69776707
121Increased density of long bones (HP:0006392)1.69758835
122Thoracolumbar scoliosis (HP:0002944)1.68685491
123Narrow nasal bridge (HP:0000446)1.65940800
124Ulnar deviation of the wrist (HP:0003049)1.65725124
125Broad face (HP:0000283)1.65700530
126Short nail (HP:0001799)1.65603748
127Arachnodactyly (HP:0001166)1.65121131
128Ovoid vertebral bodies (HP:0003300)1.64999799

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.82831375
2DDR24.56926785
3TTN4.14434134
4PDGFRA3.82026273
5PKN23.77672360
6LATS13.24111578
7RIPK12.72307724
8LATS22.68482104
9EPHB22.37978210
10SIK12.31179886
11MAP3K102.14532582
12EEF2K2.05923493
13ERN12.04744975
14PTK62.00513142
15TIE11.98802165
16PAK21.92079354
17BMX1.87673429
18DMPK1.70957217
19PTK21.66163193
20PAK41.64642472
21PIK3CG1.61432485
22AKT31.60769192
23MAP3K61.50413282
24LRRK21.47118494
25TGFBR21.37977789
26PDGFRB1.35441251
27EPHA31.33730405
28MAPK71.33610173
29FGFR11.33240489
30PRPF4B1.32342788
31FER1.27798730
32MTOR1.27390576
33PTK2B1.26982625
34STK31.26692039
35ILK1.17253077
36PAK31.14035747
37MET1.13077389
38SMG11.10531924
39ICK1.10303411
40FGFR21.07444724
41KDR1.04615605
42TGFBR10.97467367
43ROCK10.96818434
44MYLK0.92358338
45PRKD30.91721224
46CDK120.90325142
47TRPM70.89341136
48GRK50.86293194
49SCYL20.84642910
50RPS6KA40.84538384
51CAMK1D0.78891265
52EPHB10.77192802
53RET0.76894913
54ROCK20.76228237
55FGFR40.74827632
56STK38L0.72546832
57PRKD20.70147096
58CAMK1G0.69254989
59FLT30.68005914
60PAK60.67934802
61NTRK10.67317068
62PRKD10.66929134
63PRKCH0.65864953
64MAP3K30.63659079
65MOS0.62545506
66LMTK20.62379059
67PIK3CA0.61649203
68ZAP700.60862472
69MAPKAPK30.60088014
70JAK10.59140777
71MAPK40.56668909
72MAPK120.56123196
73CDK60.55955095
74WNK10.55883144
75CDC42BPA0.55676258
76TYRO30.55549772
77CAMKK10.55244163
78DAPK30.55240680
79NEK20.55069186
80HIPK20.54794373
81NEK90.54455286
82MAP3K70.53611360
83MAP3K80.50200992
84PDPK10.49023717
85INSR0.48853289
86MAP2K10.47809428
87STK380.46143093
88TYK20.45371698
89SRC0.45256380
90PAK10.44435636
91CLK10.43429633
92JAK30.42137864
93TAOK20.41878993
94GRK70.41873722
95NEK10.39544361
96CAMK10.39052711
97DYRK1B0.38546141
98MAP2K30.38531960
99PIM20.36636797
100ERBB20.36430375
101TESK10.35335836
102MARK20.34960790
103GRK60.34841933
104EPHA20.34549775
105PRKG20.33395984
106RPS6KA20.33297197
107ABL20.32205386
108MELK0.32105683
109MAPK10.31737721
110LIMK10.31717483
111ALK0.31446341
112AKT20.29925410
113ADRBK10.29440704
114GRK10.29375404
115TBK10.28708278
116TAOK10.27572931
117GSK3A0.26247374
118STK100.26121448
119FGFR30.24017347
120RPS6KC10.23601358
121RPS6KL10.23601358
122MAPKAPK20.21140560
123KSR20.20150951
124KIT0.20141075
125AKT10.19128825
126RPS6KA60.17727782

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.51797326
2Focal adhesion_Homo sapiens_hsa045103.23901611
3Protein digestion and absorption_Homo sapiens_hsa049742.90192077
4Basal cell carcinoma_Homo sapiens_hsa052172.49506970
5Proteoglycans in cancer_Homo sapiens_hsa052052.48465146
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.45787202
7Amoebiasis_Homo sapiens_hsa051462.37789575
8Adherens junction_Homo sapiens_hsa045202.18189966
9Dilated cardiomyopathy_Homo sapiens_hsa054142.15852425
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.13262318
11Small cell lung cancer_Homo sapiens_hsa052222.12408474
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.09785515
13Hedgehog signaling pathway_Homo sapiens_hsa043402.08929088
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.04261547
15Bladder cancer_Homo sapiens_hsa052192.01545077
16Hippo signaling pathway_Homo sapiens_hsa043901.98911783
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.87701114
18MicroRNAs in cancer_Homo sapiens_hsa052061.79754295
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.79193083
20Other glycan degradation_Homo sapiens_hsa005111.77632066
21Chronic myeloid leukemia_Homo sapiens_hsa052201.67660257
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.63542319
23TGF-beta signaling pathway_Homo sapiens_hsa043501.63140830
24PI3K-Akt signaling pathway_Homo sapiens_hsa041511.59563852
25Melanoma_Homo sapiens_hsa052181.41142493
26Glioma_Homo sapiens_hsa052141.34022719
27Axon guidance_Homo sapiens_hsa043601.32322739
28Notch signaling pathway_Homo sapiens_hsa043301.30606684
29Regulation of actin cytoskeleton_Homo sapiens_hsa048101.27770608
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.25681226
31Pathways in cancer_Homo sapiens_hsa052001.24929738
32Tight junction_Homo sapiens_hsa045301.20088577
33Viral myocarditis_Homo sapiens_hsa054161.19849218
34Wnt signaling pathway_Homo sapiens_hsa043101.17929612
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.17780565
36Prostate cancer_Homo sapiens_hsa052151.17726079
37Platelet activation_Homo sapiens_hsa046111.14949197
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.13261123
39Rap1 signaling pathway_Homo sapiens_hsa040151.12281358
40Melanogenesis_Homo sapiens_hsa049161.08538229
41Complement and coagulation cascades_Homo sapiens_hsa046101.05345654
42Malaria_Homo sapiens_hsa051441.03113783
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99251080
44Estrogen signaling pathway_Homo sapiens_hsa049150.99173444
45Pancreatic cancer_Homo sapiens_hsa052120.98765465
46Lysine degradation_Homo sapiens_hsa003100.98677673
47HTLV-I infection_Homo sapiens_hsa051660.97706153
48mTOR signaling pathway_Homo sapiens_hsa041500.96839703
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94564140
50Colorectal cancer_Homo sapiens_hsa052100.91933409
51Endometrial cancer_Homo sapiens_hsa052130.91252898
52Renal cell carcinoma_Homo sapiens_hsa052110.89217301
53Toxoplasmosis_Homo sapiens_hsa051450.86454213
54p53 signaling pathway_Homo sapiens_hsa041150.85690828
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84273036
56Gap junction_Homo sapiens_hsa045400.82469900
57Insulin resistance_Homo sapiens_hsa049310.82427801
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81425896
59Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81202728
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78518994
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76760064
62VEGF signaling pathway_Homo sapiens_hsa043700.74944481
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74680177
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73981900
65Pertussis_Homo sapiens_hsa051330.72759396
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.71305113
67Non-small cell lung cancer_Homo sapiens_hsa052230.71289557
68Lysosome_Homo sapiens_hsa041420.71083292
69HIF-1 signaling pathway_Homo sapiens_hsa040660.69767047
70GnRH signaling pathway_Homo sapiens_hsa049120.69703503
71Choline metabolism in cancer_Homo sapiens_hsa052310.68599675
72Shigellosis_Homo sapiens_hsa051310.65802222
73AMPK signaling pathway_Homo sapiens_hsa041520.65159588
74TNF signaling pathway_Homo sapiens_hsa046680.64530112
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63309339
76Renin secretion_Homo sapiens_hsa049240.63002961
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.62957418
78Cocaine addiction_Homo sapiens_hsa050300.62384829
79Viral carcinogenesis_Homo sapiens_hsa052030.61647935
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60861364
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.60039407
82FoxO signaling pathway_Homo sapiens_hsa040680.57507194
83Endocytosis_Homo sapiens_hsa041440.57406860
84Insulin signaling pathway_Homo sapiens_hsa049100.56483410
85cAMP signaling pathway_Homo sapiens_hsa040240.55192968
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55029788
87Prolactin signaling pathway_Homo sapiens_hsa049170.54816285
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.53969506
89Ovarian steroidogenesis_Homo sapiens_hsa049130.53936412
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53097582
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51811880
92Ras signaling pathway_Homo sapiens_hsa040140.51291516
93Calcium signaling pathway_Homo sapiens_hsa040200.51067996
94Thyroid cancer_Homo sapiens_hsa052160.50498834
95Renin-angiotensin system_Homo sapiens_hsa046140.49715343
96Thyroid hormone synthesis_Homo sapiens_hsa049180.49018624
97Hepatitis B_Homo sapiens_hsa051610.48705986
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.47966458
99MAPK signaling pathway_Homo sapiens_hsa040100.47695816
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47373768
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46657436
102ErbB signaling pathway_Homo sapiens_hsa040120.46646696
103Gastric acid secretion_Homo sapiens_hsa049710.46382363
104Salmonella infection_Homo sapiens_hsa051320.46284688
105Dorso-ventral axis formation_Homo sapiens_hsa043200.46219398
106Glucagon signaling pathway_Homo sapiens_hsa049220.45691674
107Osteoclast differentiation_Homo sapiens_hsa043800.45341405
108Oxytocin signaling pathway_Homo sapiens_hsa049210.44752180
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43854584
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.43382300
111Prion diseases_Homo sapiens_hsa050200.42982754
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38821539
113Bile secretion_Homo sapiens_hsa049760.38496072
114Acute myeloid leukemia_Homo sapiens_hsa052210.37751836
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37389021
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35919865
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35847090
118Apoptosis_Homo sapiens_hsa042100.31274811

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