ADGRA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)4.68051338
2planar cell polarity pathway involved in neural tube closure (GO:0090179)3.99870535
3midgut development (GO:0007494)3.92062568
4regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.71299429
5notochord development (GO:0030903)3.66570920
6hippo signaling (GO:0035329)3.64678153
7G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.43694526
8regulation of hippo signaling (GO:0035330)3.27759320
9outer ear morphogenesis (GO:0042473)3.24565933
10mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.23326456
11polarized epithelial cell differentiation (GO:0030859)3.21397056
12anatomical structure regression (GO:0060033)3.16276740
13gastrulation with mouth forming second (GO:0001702)3.14635932
14generation of neurons (GO:0048699)3.13618615
15hemidesmosome assembly (GO:0031581)3.07385090
16desmosome organization (GO:0002934)3.06081040
17dorsal/ventral axis specification (GO:0009950)3.04292185
18regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.98198083
19positive regulation of fatty acid beta-oxidation (GO:0032000)2.97119101
20embryonic foregut morphogenesis (GO:0048617)2.94891952
21positive regulation of catenin import into nucleus (GO:0035413)2.94750216
22lateral sprouting from an epithelium (GO:0060601)2.94319462
23metanephric mesenchyme development (GO:0072075)2.92089631
24regulation of heart morphogenesis (GO:2000826)2.88414327
25establishment of apical/basal cell polarity (GO:0035089)2.84588838
26male genitalia development (GO:0030539)2.83856645
27regulation of fatty acid beta-oxidation (GO:0031998)2.82972186
28endocardial cushion development (GO:0003197)2.82160317
29gonadal mesoderm development (GO:0007506)2.81564433
30cochlea morphogenesis (GO:0090103)2.81419525
31negative regulation of chondrocyte differentiation (GO:0032331)2.79535724
32embryonic skeletal joint morphogenesis (GO:0060272)2.73314021
33regulation of catenin import into nucleus (GO:0035412)2.73190637
34mitotic sister chromatid cohesion (GO:0007064)2.71958829
35regulation of non-canonical Wnt signaling pathway (GO:2000050)2.71958760
36glyoxylate metabolic process (GO:0046487)2.69348437
37nuclear pore complex assembly (GO:0051292)2.68769134
38collagen fibril organization (GO:0030199)2.67496992
39heterochromatin organization (GO:0070828)2.67097523
40alpha-linolenic acid metabolic process (GO:0036109)2.65753382
41proximal/distal pattern formation (GO:0009954)2.64934213
42homocysteine metabolic process (GO:0050667)2.64532877
43kidney mesenchyme development (GO:0072074)2.64092393
44insulin-like growth factor receptor signaling pathway (GO:0048009)2.63722079
45positive regulation of hormone biosynthetic process (GO:0046886)2.62413746
46lysine catabolic process (GO:0006554)2.60688219
47lysine metabolic process (GO:0006553)2.60688219
48regulation of transforming growth factor beta2 production (GO:0032909)2.60169860
49regulation of SMAD protein import into nucleus (GO:0060390)2.57699634
50regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.56472275
51positive regulation of SMAD protein import into nucleus (GO:0060391)2.56275796
52epithelial cell-cell adhesion (GO:0090136)2.54301305
53mesenchyme development (GO:0060485)2.52078486
54organ growth (GO:0035265)2.50876153
55anterior/posterior axis specification, embryo (GO:0008595)2.49127429
56regulation of gene silencing by RNA (GO:0060966)2.48901423
57regulation of posttranscriptional gene silencing (GO:0060147)2.48901423
58regulation of gene silencing by miRNA (GO:0060964)2.48901423
59Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.48584932
60chondrocyte proliferation (GO:0035988)2.47000844
61negative regulation of cell fate specification (GO:0009996)2.46406375
62serine family amino acid catabolic process (GO:0009071)2.45803517
63dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.45067923
64cellular response to cholesterol (GO:0071397)2.44600066
65negative regulation of DNA repair (GO:0045738)2.44579653
66non-canonical Wnt signaling pathway (GO:0035567)2.44560740
67cell migration involved in sprouting angiogenesis (GO:0002042)2.44361551
68establishment of tissue polarity (GO:0007164)2.43975156
69establishment of planar polarity (GO:0001736)2.43975156
70basement membrane organization (GO:0071711)2.43366935
71organ induction (GO:0001759)2.43065738
72mesenchymal to epithelial transition (GO:0060231)2.42580615
73pre-miRNA processing (GO:0031054)2.42502714
74limb bud formation (GO:0060174)2.41304983
75negative regulation of fibrinolysis (GO:0051918)2.40600803
76embryonic camera-type eye development (GO:0031076)2.40430907
77regulation of sister chromatid cohesion (GO:0007063)2.40410908
78nuclear pore organization (GO:0006999)2.39941243
79artery development (GO:0060840)2.39537791
80L-phenylalanine metabolic process (GO:0006558)2.38945695
81erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.38945695
82bone trabecula formation (GO:0060346)2.38612020
83erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.38437668
84L-phenylalanine catabolic process (GO:0006559)2.38437668
85establishment or maintenance of monopolar cell polarity (GO:0061339)2.38386850
86establishment of monopolar cell polarity (GO:0061162)2.38386850
87glycine metabolic process (GO:0006544)2.38276813
88regulation of establishment of planar polarity (GO:0090175)2.37771459
89positive regulation of epithelial to mesenchymal transition (GO:0010718)2.36884490
90L-serine metabolic process (GO:0006563)2.35456395
91hindlimb morphogenesis (GO:0035137)2.35055202
92cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.34799697
93sulfur amino acid catabolic process (GO:0000098)2.34731485
94regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.33421675
95axon extension involved in axon guidance (GO:0048846)2.33403303
96neuron projection extension involved in neuron projection guidance (GO:1902284)2.33403303
97regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.33253892
98negative regulation of cartilage development (GO:0061037)2.32759868
99regulation of cardioblast differentiation (GO:0051890)2.32443612
100negative regulation of keratinocyte proliferation (GO:0010839)2.32007326
101cytoplasmic mRNA processing body assembly (GO:0033962)2.31604994
102negative regulation of catenin import into nucleus (GO:0035414)2.31344685
103embryonic viscerocranium morphogenesis (GO:0048703)2.31054252
104chondrocyte development (GO:0002063)2.29952566
105regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.29397816
106cell surface receptor signaling pathway involved in heart development (GO:0061311)2.28490693
107convergent extension (GO:0060026)2.28474345
108gap junction assembly (GO:0016264)2.27672327
109cysteine metabolic process (GO:0006534)2.27354785
110lung-associated mesenchyme development (GO:0060484)2.26939825
111epithelial cell differentiation involved in prostate gland development (GO:0060742)2.26702161
112otic vesicle formation (GO:0030916)2.25189101
113renal system development (GO:0072001)2.25181437
114positive regulation of hormone metabolic process (GO:0032352)2.24947591
115embryonic retina morphogenesis in camera-type eye (GO:0060059)2.24697924
116glomerular basement membrane development (GO:0032836)2.24592861
117regulation of cell fate specification (GO:0042659)2.24312611
118regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.22783567
119positive regulation of dendritic spine morphogenesis (GO:0061003)2.22341510
120DNA unwinding involved in DNA replication (GO:0006268)2.20760417
121nephron tubule formation (GO:0072079)2.18366367
122exogenous drug catabolic process (GO:0042738)2.17541949
123regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.16293092
124morphogenesis of an epithelial sheet (GO:0002011)2.14685679
125branching involved in salivary gland morphogenesis (GO:0060445)2.09575381
126negative regulation of astrocyte differentiation (GO:0048712)2.07454511
127prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.07000099
128biotin metabolic process (GO:0006768)2.02513720
129bundle of His cell to Purkinje myocyte communication (GO:0086069)2.01840904
130cellular response to sterol (GO:0036315)2.00943320
131NLS-bearing protein import into nucleus (GO:0006607)1.99989142
132positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)1.99869476
133regulation of protein activation cascade (GO:2000257)1.99684353
134myoblast migration (GO:0051451)1.99486664
135regulation of centriole replication (GO:0046599)1.99346876
136drug catabolic process (GO:0042737)1.96719036
137presynaptic membrane assembly (GO:0097105)1.96308690
138cell migration involved in gastrulation (GO:0042074)1.96090198
139regulation of fibrinolysis (GO:0051917)1.92148722
140asymmetric protein localization (GO:0008105)1.91143987
141neural tube development (GO:0021915)1.90503906
142myelination in peripheral nervous system (GO:0022011)1.88974593
143peripheral nervous system axon ensheathment (GO:0032292)1.88974593
144ectodermal placode formation (GO:0060788)1.88194235
145apical protein localization (GO:0045176)1.88017051
146genitalia morphogenesis (GO:0035112)1.87464174
147mitotic chromosome condensation (GO:0007076)1.86516373
148regulation of complement activation (GO:0030449)1.86386260
149short-term memory (GO:0007614)1.85855742

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.87465586
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.96146914
3RXR_22158963_ChIP-Seq_LIVER_Mouse2.80746810
4CLOCK_20551151_ChIP-Seq_293T_Human2.77165781
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.74629785
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.57969271
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.57207798
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.51700473
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.42718389
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.39174427
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.35973831
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.34890529
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25643467
14E2F7_22180533_ChIP-Seq_HELA_Human2.23335597
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.18863985
16AR_21909140_ChIP-Seq_LNCAP_Human2.16562837
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.13498067
18HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.10472829
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08682160
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.01654464
21ZNF263_19887448_ChIP-Seq_K562_Human1.98092694
22KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.92696786
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.92696786
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.92696786
25NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.81637227
26ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.80625081
27GBX2_23144817_ChIP-Seq_PC3_Human1.79768186
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.78706502
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.77416631
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.75587744
31SOX9_24532713_ChIP-Seq_HFSC_Mouse1.75314497
32KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.73022797
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72119065
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.71912448
35TCF3_18692474_ChIP-Seq_MEFs_Mouse1.70409570
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.65813781
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.61640099
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59450296
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.58853872
40EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.58673846
41ISL1_27105846_Chip-Seq_CPCs_Mouse1.58099408
42TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.57076227
43SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.55154671
44FUS_26573619_Chip-Seq_HEK293_Human1.55016961
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.49991544
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.49910886
47EP300_21415370_ChIP-Seq_HL-1_Mouse1.46894052
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.44807138
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.44174788
50SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.42212800
51PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.42013580
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39945333
53ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39827584
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.38341418
55P300_27058665_Chip-Seq_ZR-75-30cells_Human1.38071378
56FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.37663002
57SALL4_18804426_ChIP-ChIP_XEN_Mouse1.37317930
58KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36388542
59FOXO3_23340844_ChIP-Seq_DLD1_Human1.35919394
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34742353
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.33028118
62TCF3_18692474_ChIP-Seq_MESCs_Mouse1.32976175
63DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.31732601
64SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.31482509
65SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.31482509
66ATF3_27146783_Chip-Seq_COLON_Human1.30923266
67WT1_19549856_ChIP-ChIP_CCG9911_Human1.30178434
68ZFP281_27345836_Chip-Seq_ESCs_Mouse1.28993975
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26088541
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25996452
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25620271
72SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.25471414
73NANOG_16153702_ChIP-ChIP_HESCs_Human1.25345908
74CHD1_26751641_Chip-Seq_LNCaP_Human1.24820022
75SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.23735164
76STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.23279303
77RACK7_27058665_Chip-Seq_MCF-7_Human1.22815581
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.22285887
79CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22157527
80TBX3_20139965_ChIP-Seq_ESCs_Mouse1.21712176
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.20533972
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20522454
83TBX3_20139965_ChIP-Seq_MESCs_Mouse1.20357857
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20337596
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19705752
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18255487
87FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.16772320
88EZH2_27304074_Chip-Seq_ESCs_Mouse1.15949397
89UBF1/2_26484160_Chip-Seq_HMECs_Human1.15673315
90SOX9_26525672_Chip-Seq_HEART_Mouse1.15621334
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15605185
92GATA6_25053715_ChIP-Seq_YYC3_Human1.14994068
93SOX2_16153702_ChIP-ChIP_HESCs_Human1.14979643
94BRD4_25478319_ChIP-Seq_HGPS_Human1.14872097
95POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.14547311
96NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.13356407
97NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.13344191
98EGR1_19374776_ChIP-ChIP_THP-1_Human1.13325743
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13037787
100RING1B_27294783_Chip-Seq_NPCs_Mouse1.12580468
101HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12486322
102CBX2_27304074_Chip-Seq_ESCs_Mouse1.11265818
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10864252
104SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10799403
105GATA4_25053715_ChIP-Seq_YYC3_Human1.10540677
106ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09898667
107EED_16625203_ChIP-ChIP_MESCs_Mouse1.09258503
108ESR1_20079471_ChIP-ChIP_T-47D_Human1.09080560
109RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09029515
110EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09029515
111FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.08965630
112NANOG_21062744_ChIP-ChIP_HESCs_Human1.08867667
113SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08528063
114PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08253334
115TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07970945
116E2F1_21310950_ChIP-Seq_MCF-7_Human1.07953706
117TP53_20018659_ChIP-ChIP_R1E_Mouse1.07346999
118TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07206641
119RUNX1_27514584_Chip-Seq_MCF-7_Human1.07202318
120FOXA2_19822575_ChIP-Seq_HepG2_Human1.07061975
121ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06742691
122P300_19829295_ChIP-Seq_ESCs_Human1.05754078
123CJUN_26792858_Chip-Seq_BT549_Human1.05721475
124YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04764357
125POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03763952
126SMAD4_21799915_ChIP-Seq_A2780_Human1.03749272
127ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02934463
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02915551
129GATA1_26923725_Chip-Seq_HPCs_Mouse1.02816036
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01464382
131NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01242709
132POU5F1_16518401_ChIP-PET_MESCs_Mouse1.01123227
133HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00905555
134IGF1R_20145208_ChIP-Seq_DFB_Human1.00655860
135PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00079511
136MYC_18555785_ChIP-Seq_MESCs_Mouse0.99320767
137SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99312818
138TCF4_18268006_ChIP-ChIP_LS174T_Human0.98863075
139NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98463011
140ELK3_25401928_ChIP-Seq_HUVEC_Human0.97337988
141ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97234657
142FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.96877090
143PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96364420
144CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96306542
145FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95735050
146TP53_18474530_ChIP-ChIP_U2OS_Human0.95164047
147OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94550786
148PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93878495
149TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93071124
150KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93045707
151TAF15_26573619_Chip-Seq_HEK293_Human0.92489322
152PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92421161
153SMAD3_21741376_ChIP-Seq_HESCs_Human0.92386460
154STAT3_23295773_ChIP-Seq_U87_Human0.91689893
155SOX17_20123909_ChIP-Seq_XEN_Mouse0.91305689
156TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.90605887
157LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88715421

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.92210432
2MP0009053_abnormal_anal_canal3.18941763
3MP0010030_abnormal_orbit_morphology3.02273893
4MP0000537_abnormal_urethra_morphology2.63712179
5MP0010234_abnormal_vibrissa_follicle2.47290569
6MP0002139_abnormal_hepatobiliary_system2.40284945
7MP0005275_abnormal_skin_tensile2.39359653
8MP0003941_abnormal_skin_development2.34952773
9MP0005360_urolithiasis2.29295284
10MP0008438_abnormal_cutaneous_collagen2.12045965
11MP0004272_abnormal_basement_membrane2.04850898
12MP0001299_abnormal_eye_distance/1.89951304
13MP0002249_abnormal_larynx_morphology1.85504634
14MP0005248_abnormal_Harderian_gland1.81576224
15MP0005503_abnormal_tendon_morphology1.80213450
16MP0010352_gastrointestinal_tract_polyps1.78404548
17MP0009384_cardiac_valve_regurgitation1.74611498
18MP0003123_paternal_imprinting1.74349133
19MP0003385_abnormal_body_wall1.73962083
20MP0002796_impaired_skin_barrier1.73404431
21MP0003942_abnormal_urinary_system1.67094892
22MP0003136_yellow_coat_color1.66904727
23MP0002282_abnormal_trachea_morphology1.66567696
24MP0000566_synostosis1.61838677
25MP0010678_abnormal_skin_adnexa1.59982146
26MP0003937_abnormal_limbs/digits/tail_de1.56986978
27MP0005085_abnormal_gallbladder_physiolo1.56240009
28MP0000383_abnormal_hair_follicle1.53874792
29MP0003252_abnormal_bile_duct1.52868414
30MP0005365_abnormal_bile_salt1.51409232
31MP0002060_abnormal_skin_morphology1.50709420
32MP0009250_abnormal_appendicular_skeleto1.49428740
33MP0002098_abnormal_vibrissa_morphology1.46357795
34MP0000762_abnormal_tongue_morphology1.42933508
35MP0001849_ear_inflammation1.41025254
36MP0005076_abnormal_cell_differentiation1.38568069
37MP0003115_abnormal_respiratory_system1.38458194
38MP0006054_spinal_hemorrhage1.37388973
39MP0000579_abnormal_nail_morphology1.36969639
40MP0000534_abnormal_ureter_morphology1.36162725
41MP0003755_abnormal_palate_morphology1.35972103
42MP0005623_abnormal_meninges_morphology1.35608219
43MP0002932_abnormal_joint_morphology1.35400616
44MP0004197_abnormal_fetal_growth/weight/1.35017753
45MP0005187_abnormal_penis_morphology1.34719266
46MP0002233_abnormal_nose_morphology1.33871305
47MP0006292_abnormal_olfactory_placode1.33569394
48MP0003119_abnormal_digestive_system1.32310306
49MP0001346_abnormal_lacrimal_gland1.30551106
50MP0000778_abnormal_nervous_system1.29610597
51MP0003935_abnormal_craniofacial_develop1.29556091
52MP0005377_hearing/vestibular/ear_phenot1.25118223
53MP0003878_abnormal_ear_physiology1.25118223
54MP0003566_abnormal_cell_adhesion1.25110510
55MP0000467_abnormal_esophagus_morphology1.24498706
56MP0000428_abnormal_craniofacial_morphol1.24374830
57MP0002111_abnormal_tail_morphology1.20711923
58MP0005508_abnormal_skeleton_morphology1.20247266
59MP0003567_abnormal_fetal_cardiomyocyte1.18993694
60MP0004133_heterotaxia1.17960380
61MP0000733_abnormal_muscle_development1.17608060
62MP0000432_abnormal_head_morphology1.17265562
63MP0008932_abnormal_embryonic_tissue1.17209564
64MP0003861_abnormal_nervous_system1.15379048
65MP0003283_abnormal_digestive_organ1.15049862
66MP0000647_abnormal_sebaceous_gland1.14896746
67MP0000049_abnormal_middle_ear1.14792816
68MP0002084_abnormal_developmental_patter1.14782564
69MP0005501_abnormal_skin_physiology1.14715903
70MP0000462_abnormal_digestive_system1.12852777
71MP0008789_abnormal_olfactory_epithelium1.11014529
72MP0002697_abnormal_eye_size1.10789278
73MP0000427_abnormal_hair_cycle1.10459977
74MP0000377_abnormal_hair_follicle1.10206458
75MP0002896_abnormal_bone_mineralization1.09609568
76MP0009697_abnormal_copulation1.09385928
77MP0010368_abnormal_lymphatic_system1.09130737
78MP0003121_genomic_imprinting1.08878774
79MP0002938_white_spotting1.08346013
80MP0002092_abnormal_eye_morphology1.08328862
81MP0000163_abnormal_cartilage_morphology1.08294144
82MP0004957_abnormal_blastocyst_morpholog1.07120227
83MP0003315_abnormal_perineum_morphology1.06100101
84MP0003122_maternal_imprinting1.04831160
85MP0001293_anophthalmia1.04681778
86MP0009703_decreased_birth_body1.04121751
87MP0002089_abnormal_postnatal_growth/wei1.03142010
88MP0003938_abnormal_ear_development1.03067143
89MP0003195_calcinosis1.01806009
90MP0002116_abnormal_craniofacial_bone1.01780837
91MP0003693_abnormal_embryo_hatching1.01568104
92MP0002085_abnormal_embryonic_tissue1.00430455
93MP0009780_abnormal_chondrocyte_physiolo1.00344695
94MP0002109_abnormal_limb_morphology1.00030876
95MP0004264_abnormal_extraembryonic_tissu0.98015200
96MP0002115_abnormal_skeleton_extremities0.97752177
97MP0001666_abnormal_nutrient_absorption0.97164268
98MP0002254_reproductive_system_inflammat0.97160830
99MP0003453_abnormal_keratinocyte_physiol0.94756686
100MP0001340_abnormal_eyelid_morphology0.94379978
101MP0003943_abnormal_hepatobiliary_system0.94312606
102MP0001661_extended_life_span0.93861821
103MP0001177_atelectasis0.93663605
104MP0009672_abnormal_birth_weight0.93619310
105MP0010094_abnormal_chromosome_stability0.93385908
106MP0005023_abnormal_wound_healing0.93316278
107MP0001216_abnormal_epidermal_layer0.90139165
108MP0003890_abnormal_embryonic-extraembry0.89938551
109MP0005197_abnormal_uvea_morphology0.88920488
110MP0002102_abnormal_ear_morphology0.88899746
111MP0002086_abnormal_extraembryonic_tissu0.88391587
112MP0005408_hypopigmentation0.88279241
113MP0002114_abnormal_axial_skeleton0.87661937
114MP0001730_embryonic_growth_arrest0.87605489
115MP0001672_abnormal_embryogenesis/_devel0.87158911
116MP0005380_embryogenesis_phenotype0.87158911
117MP0005257_abnormal_intraocular_pressure0.86977516
118MP0002108_abnormal_muscle_morphology0.86195033
119MP0001286_abnormal_eye_development0.84533018
120MP0004233_abnormal_muscle_weight0.83382892
121MP0002088_abnormal_embryonic_growth/wei0.83127931
122MP0005367_renal/urinary_system_phenotyp0.81789309
123MP0000516_abnormal_urinary_system0.81789309
124MP0001915_intracranial_hemorrhage0.81715115
125MP0001958_emphysema0.81391384
126MP0003984_embryonic_growth_retardation0.81221568
127MP0002234_abnormal_pharynx_morphology0.80678086
128MP0003111_abnormal_nucleus_morphology0.79796350
129MP0000751_myopathy0.77635206
130MP0000631_abnormal_neuroendocrine_gland0.77472867
131MP0001697_abnormal_embryo_size0.76125469
132MP0002081_perinatal_lethality0.75326654
133MP0002751_abnormal_autonomic_nervous0.72635665
134MP0003868_abnormal_feces_composition0.72481525
135MP0005391_vision/eye_phenotype0.72394150

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.64986296
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.33650145
3Short 4th metacarpal (HP:0010044)3.33650145
4Shallow orbits (HP:0000586)3.16760660
5Abnormality of the 4th metacarpal (HP:0010012)3.13442478
6Ankle contracture (HP:0006466)2.70055345
7Deep venous thrombosis (HP:0002625)2.67443055
8Neonatal short-limb short stature (HP:0008921)2.64545704
9Premature rupture of membranes (HP:0001788)2.57902820
10Renal duplication (HP:0000075)2.54841136
11Lymphangioma (HP:0100764)2.44376162
12Rectal prolapse (HP:0002035)2.38880474
13Vitreoretinal degeneration (HP:0000655)2.36909948
14Atrophic scars (HP:0001075)2.28075771
15Preaxial foot polydactyly (HP:0001841)2.28068135
16Cutaneous syndactyly (HP:0012725)2.27027204
17Hepatoblastoma (HP:0002884)2.26714182
18Hypoplastic ischia (HP:0003175)2.21825188
19Hypoplastic labia majora (HP:0000059)2.21551299
20Mitral valve prolapse (HP:0001634)2.20635907
21Broad metatarsal (HP:0001783)2.19672333
22Right ventricular cardiomyopathy (HP:0011663)2.17798441
23Coronal craniosynostosis (HP:0004440)2.17434872
24Midline defect of the nose (HP:0004122)2.16658226
25Subacute progressive viral hepatitis (HP:0006572)2.16242057
26Selective tooth agenesis (HP:0001592)2.14499607
27Mesomelia (HP:0003027)2.12927622
28Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.06689574
29Bladder diverticulum (HP:0000015)2.04967575
30Turricephaly (HP:0000262)2.04294375
31Metaphyseal cupping (HP:0003021)2.02774414
32High anterior hairline (HP:0009890)2.02451332
33Deviation of the hallux (HP:0010051)2.02327156
34Abnormality of the labia majora (HP:0012881)2.02108063
35Intrahepatic cholestasis (HP:0001406)2.02008066
36Abnormality of the ischium (HP:0003174)2.01858974
37Spastic diplegia (HP:0001264)2.01727194
38Pseudobulbar signs (HP:0002200)2.00911878
39Renovascular hypertension (HP:0100817)2.00839014
40Short 5th finger (HP:0009237)1.97671427
41Broad thumb (HP:0011304)1.97159984
42Aplasia involving bones of the extremities (HP:0009825)1.96385163
43Aplasia involving bones of the upper limbs (HP:0009823)1.96385163
44Aplasia of the phalanges of the hand (HP:0009802)1.96385163
45Advanced eruption of teeth (HP:0006288)1.95361800
46Epiphyseal dysplasia (HP:0002656)1.94939356
47Wide anterior fontanel (HP:0000260)1.92656122
48Exostoses (HP:0100777)1.90644517
49Hallux valgus (HP:0001822)1.90417819
50Colon cancer (HP:0003003)1.88880114
51Natal tooth (HP:0000695)1.88299589
52Increased nuchal translucency (HP:0010880)1.87897313
53Alopecia of scalp (HP:0002293)1.86750176
54Esophageal atresia (HP:0002032)1.85903177
55Synostosis of carpal bones (HP:0005048)1.84522679
56Hypoplastic pelvis (HP:0008839)1.82096822
57Abnormality of the distal phalanges of the toes (HP:0010182)1.81975425
58Choanal stenosis (HP:0000452)1.81489229
59Arterial tortuosity (HP:0005116)1.80812212
60Back pain (HP:0003418)1.80739486
61Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.80289019
62Abnormality of the calcaneus (HP:0008364)1.80202391
63Partial duplication of thumb phalanx (HP:0009944)1.79623958
64Bifid tongue (HP:0010297)1.79061150
65Follicular hyperkeratosis (HP:0007502)1.78886711
66Increased connective tissue (HP:0009025)1.78330737
67Abnormality of monocarboxylic acid metabolism (HP:0010996)1.77192016
68Calcaneovalgus deformity (HP:0001848)1.76643310
69Abnormality of the 2nd finger (HP:0004100)1.75280478
70Cerebral aneurysm (HP:0004944)1.75242055
71Germ cell neoplasia (HP:0100728)1.74821441
72Asymmetry of the thorax (HP:0001555)1.74488824
73Woolly hair (HP:0002224)1.73579404
74Nephroblastoma (Wilms tumor) (HP:0002667)1.72282621
75Skull defect (HP:0001362)1.71859421
76Aortic dissection (HP:0002647)1.71843735
77Ulnar bowing (HP:0003031)1.71266675
78Absent eyebrow (HP:0002223)1.70979251
79Abnormality of the distal phalanx of the thumb (HP:0009617)1.70345633
80Prolonged partial thromboplastin time (HP:0003645)1.69304759
81Microglossia (HP:0000171)1.68679464
82Milia (HP:0001056)1.68675352
83Blue sclerae (HP:0000592)1.68674058
84Thin bony cortex (HP:0002753)1.68415509
85Limited hip movement (HP:0008800)1.67521597
86Aortic aneurysm (HP:0004942)1.67127977
87Missing ribs (HP:0000921)1.66712606
88Duplication of thumb phalanx (HP:0009942)1.65556675
89Broad long bones (HP:0005622)1.65377361
90Hypotrichosis (HP:0001006)1.64662411
91Abnormal lung lobation (HP:0002101)1.64216905
92Hepatocellular carcinoma (HP:0001402)1.64062935
93Camptodactyly of toe (HP:0001836)1.62850749
94Elfin facies (HP:0004428)1.62531109
95Embryonal renal neoplasm (HP:0011794)1.62398461
96Abnormality of dentin (HP:0010299)1.62387157
97Pili torti (HP:0003777)1.61510557
98Xanthomatosis (HP:0000991)1.61090430
99Cervical subluxation (HP:0003308)1.60571698
100Soft skin (HP:0000977)1.60047475
101Enlarged penis (HP:0000040)1.59167382
102Hypobetalipoproteinemia (HP:0003563)1.58901571
103Partial duplication of the phalanx of hand (HP:0009999)1.58353508
104Hip contracture (HP:0003273)1.57649062
105Aplasia/Hypoplasia of the sternum (HP:0006714)1.57600143
106Broad phalanges of the hand (HP:0009768)1.57139504
107Down-sloping shoulders (HP:0200021)1.57123529
108Broad finger (HP:0001500)1.56765494
109Broad phalanx (HP:0006009)1.56470092
110Carpal synostosis (HP:0009702)1.56366888
111Broad toe (HP:0001837)1.55937116
112Vascular tortuosity (HP:0004948)1.55601402
113Vertebral clefting (HP:0008428)1.54895557
114Sprengel anomaly (HP:0000912)1.54490327
115Rhizomelia (HP:0008905)1.54132195
116Chromosomal breakage induced by crosslinking agents (HP:0003221)1.53967512
117Fragile skin (HP:0001030)1.53254074
118Abnormal cartilage morphology (HP:0002763)1.53026577
119Abnormality of the lower motor neuron (HP:0002366)1.52622688
120Abnormality of glutamine family amino acid metabolism (HP:0010902)1.52562389
121Abnormality of the nasal septum (HP:0000419)1.52523416
122Bifid scrotum (HP:0000048)1.52219148
123Knee flexion contracture (HP:0006380)1.52127927
124Cutaneous finger syndactyly (HP:0010554)1.52038768
125Vertebral arch anomaly (HP:0008438)1.51690502
126Bowel diverticulosis (HP:0005222)1.51647267
127Hand muscle atrophy (HP:0009130)1.51245944
128Alacrima (HP:0000522)1.51244515
129Absent eyelashes (HP:0000561)1.51221062
130Deformed tarsal bones (HP:0008119)1.50576291
131Hyperglycinemia (HP:0002154)1.50347063
132Short middle phalanx of the 5th finger (HP:0004220)1.49884530
133Hypoplastic toenails (HP:0001800)1.49864464
134Pterygium (HP:0001059)1.49795418
135Bronchomalacia (HP:0002780)1.49381474
136Flat acetabular roof (HP:0003180)1.48858265
137Aneurysm (HP:0002617)1.48799961
138Genu recurvatum (HP:0002816)1.48418036
139Gastrointestinal atresia (HP:0002589)1.48210426
140Arnold-Chiari malformation (HP:0002308)1.46218358
141Overriding aorta (HP:0002623)1.46094315
142Hyperglycinuria (HP:0003108)1.45387112
143Anophthalmia (HP:0000528)1.45246469
144Megalencephaly (HP:0001355)1.45043565
145Abnormality of the aortic arch (HP:0012303)1.44820730
146Transposition of the great arteries (HP:0001669)1.43765582
147Abnormal connection of the cardiac segments (HP:0011545)1.43765582
148Abnormal ventriculo-arterial connection (HP:0011563)1.43765582
149Chromsome breakage (HP:0040012)1.43433012
150Complement deficiency (HP:0004431)1.42712196
151Abnormality of the middle phalanges of the toes (HP:0010183)1.41498419
152Myelomeningocele (HP:0002475)1.41420014
153Renal hypoplasia (HP:0000089)1.39966241
154Omphalocele (HP:0001539)1.39182993
155Septo-optic dysplasia (HP:0100842)1.39029427
156Decreased lacrimation (HP:0000633)1.38444855
157Abnormality of the pubic bones (HP:0003172)1.37016627
158Absent radius (HP:0003974)1.35814099
159Hypoalphalipoproteinemia (HP:0003233)1.33932091
160Absent forearm bone (HP:0003953)1.33672039
161Aplasia involving forearm bones (HP:0009822)1.33672039
162Hypolipoproteinemia (HP:0010981)1.33612527
163Rhabdomyosarcoma (HP:0002859)1.32989996
164Diastasis recti (HP:0001540)1.32186600
165Atresia of the external auditory canal (HP:0000413)1.31801695

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.54815241
2PKN23.24025237
3TRIB33.19542968
4DDR22.77691630
5LATS22.48109432
6RIPK12.46528979
7PDGFRA2.38605774
8CDK122.34770383
9EEF2K2.33577489
10STK38L2.23789776
11SIK12.22794731
12EPHB22.20141528
13CASK2.17430570
14MAP3K102.17067634
15PTK62.10729490
16MAP3K31.88432380
17PNCK1.86090190
18STK31.76669463
19NTRK11.70072732
20ERBB31.66770461
21TTN1.66519987
22MET1.65836633
23MST1R1.64064405
24MKNK11.64029840
25FER1.53789873
26MKNK21.51892032
27CDK61.44628296
28EPHA21.41783132
29TSSK61.41356065
30FGFR21.39627582
31ICK1.39056899
32PBK1.37427733
33TYRO31.37103235
34FGFR11.36637381
35MTOR1.34318904
36RPS6KB21.32199881
37PAK41.31011989
38ZAK1.28101342
39TGFBR11.27987364
40TTK1.27898532
41CDC71.26484318
42SRPK11.25318535
43EPHA41.19806926
44PTK21.19434084
45ERBB41.16391712
46MAP3K21.15568209
47PLK41.15308159
48FGFR41.13508520
49BMX1.12022612
50ERBB21.11580001
51NEK21.11337452
52BRSK21.11053673
53AKT31.10724237
54PAK21.04881703
55TNIK1.04832724
56TAF11.03550304
57ERN11.01539683
58BCKDK1.01058375
59CDK70.99694566
60FRK0.95679669
61PRKD30.95451722
62PASK0.94863974
63BRD40.94643528
64OBSCN0.93720413
65NEK10.92948054
66WNK10.89911962
67CDK40.87623162
68LRRK20.87292851
69BUB10.84512189
70DYRK1B0.81623437
71STK390.81083274
72STK240.77353716
73CDK190.76363539
74FLT30.75609845
75EPHA30.75342107
76ACVR1B0.74860529
77WNK30.73307393
78PDGFRB0.73100196
79BMPR1B0.68715525
80CAMK1D0.68360775
81BCR0.68348156
82MAP3K80.66070353
83KSR10.65181820
84TGFBR20.65057179
85NLK0.62850332
86MAPKAPK30.62819911
87RET0.62790338
88MAP3K40.61150129
89MARK10.60410002
90MELK0.59449078
91CSNK1A1L0.57985813
92PIK3CA0.57619078
93AURKB0.56555299
94STK100.56394650
95NUAK10.56227422
96NTRK20.55668186
97CDK80.54387726
98FGFR30.52236314
99CDK30.52142108
100SMG10.51768184
101NTRK30.50799458
102PRKDC0.50719952
103PAK30.50476053
104AKT20.50150634
105TRPM70.49743417
106RPS6KA40.49718292
107LMTK20.49676863
108CDK90.49653525
109NEK90.49011728
110GSK3A0.48705995
111WEE10.47945822
112BRSK10.47101979
113EIF2AK20.45596243
114PHKG20.45448369
115PHKG10.45448369
116ROCK10.45153083
117CHEK10.44791772
118SGK20.43234232
119MAP3K70.42470454
120SGK4940.42362407
121SGK2230.42362407
122PLK10.41501450
123ATM0.41100991
124CSNK1G10.41099664
125DMPK0.40274202
126ATR0.39485177
127MAP2K20.38710344
128WNK40.37459565
129MAP2K10.36958123
130CSNK1E0.36624394
131CAMK1G0.36537359
132ILK0.35742549
133CHEK20.35627083
134CDK20.34873277
135RPS6KA10.32802329
136MAPK10.32006071
137CSNK1D0.31222692
138CDK10.30243249
139AKT10.30146125
140PLK30.30074487

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.64448294
2Basal cell carcinoma_Homo sapiens_hsa052172.37433375
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.31324323
4Nitrogen metabolism_Homo sapiens_hsa009102.13725709
5Lysine degradation_Homo sapiens_hsa003102.10991465
6Fatty acid degradation_Homo sapiens_hsa000712.06364779
7ECM-receptor interaction_Homo sapiens_hsa045121.99389769
8Hippo signaling pathway_Homo sapiens_hsa043901.87460085
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.86165917
10Selenocompound metabolism_Homo sapiens_hsa004501.80539312
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.80077601
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.74997959
13Tryptophan metabolism_Homo sapiens_hsa003801.73290707
14Fatty acid metabolism_Homo sapiens_hsa012121.72093097
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.71502746
16Adherens junction_Homo sapiens_hsa045201.71216526
17Hedgehog signaling pathway_Homo sapiens_hsa043401.70776110
18Arginine biosynthesis_Homo sapiens_hsa002201.65040365
19TGF-beta signaling pathway_Homo sapiens_hsa043501.64220086
20Protein digestion and absorption_Homo sapiens_hsa049741.64070868
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61248727
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.60172643
23Propanoate metabolism_Homo sapiens_hsa006401.58948848
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.53589977
25One carbon pool by folate_Homo sapiens_hsa006701.49272919
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48682153
27Butanoate metabolism_Homo sapiens_hsa006501.45426884
28Vitamin B6 metabolism_Homo sapiens_hsa007501.40500451
29Complement and coagulation cascades_Homo sapiens_hsa046101.40068114
30PPAR signaling pathway_Homo sapiens_hsa033201.38856537
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.32066028
32Fat digestion and absorption_Homo sapiens_hsa049751.31121676
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.29055888
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.28302763
35Bile secretion_Homo sapiens_hsa049761.27132409
36Retinol metabolism_Homo sapiens_hsa008301.26617217
37Chemical carcinogenesis_Homo sapiens_hsa052041.25404100
38Small cell lung cancer_Homo sapiens_hsa052221.25296557
39Focal adhesion_Homo sapiens_hsa045101.22941601
40Non-homologous end-joining_Homo sapiens_hsa034501.19911594
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.19255568
42Proteoglycans in cancer_Homo sapiens_hsa052051.19185514
43MicroRNAs in cancer_Homo sapiens_hsa052061.17579908
44Pentose and glucuronate interconversions_Homo sapiens_hsa000401.16101924
45Tyrosine metabolism_Homo sapiens_hsa003501.12902216
46Bladder cancer_Homo sapiens_hsa052191.11697475
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11318997
48beta-Alanine metabolism_Homo sapiens_hsa004101.09832031
49Notch signaling pathway_Homo sapiens_hsa043301.07718173
50Phenylalanine metabolism_Homo sapiens_hsa003601.07696683
51Biosynthesis of amino acids_Homo sapiens_hsa012301.06747600
52Pyruvate metabolism_Homo sapiens_hsa006201.04018766
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03735753
54Tight junction_Homo sapiens_hsa045301.02799063
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00806039
56Histidine metabolism_Homo sapiens_hsa003400.98977728
57DNA replication_Homo sapiens_hsa030300.90755224
58Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.89832628
59Carbon metabolism_Homo sapiens_hsa012000.89557006
60Fatty acid biosynthesis_Homo sapiens_hsa000610.88636101
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.87720671
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.85953725
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85326882
64Starch and sucrose metabolism_Homo sapiens_hsa005000.85319124
65Peroxisome_Homo sapiens_hsa041460.85318844
66Wnt signaling pathway_Homo sapiens_hsa043100.85023806
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.83313241
68Dilated cardiomyopathy_Homo sapiens_hsa054140.81903997
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79756840
70Arginine and proline metabolism_Homo sapiens_hsa003300.79411538
71Cell cycle_Homo sapiens_hsa041100.78964678
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78688736
73Vitamin digestion and absorption_Homo sapiens_hsa049770.78487989
74Mismatch repair_Homo sapiens_hsa034300.76931526
75Endometrial cancer_Homo sapiens_hsa052130.76736187
76Glucagon signaling pathway_Homo sapiens_hsa049220.76192584
77Sulfur metabolism_Homo sapiens_hsa009200.75032373
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74767311
79Insulin resistance_Homo sapiens_hsa049310.72716680
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72390511
81Thyroid cancer_Homo sapiens_hsa052160.70727625
82Amoebiasis_Homo sapiens_hsa051460.70644108
83Folate biosynthesis_Homo sapiens_hsa007900.65253689
84Chronic myeloid leukemia_Homo sapiens_hsa052200.64205654
85Ovarian steroidogenesis_Homo sapiens_hsa049130.63677144
86Nucleotide excision repair_Homo sapiens_hsa034200.63470941
87Thyroid hormone synthesis_Homo sapiens_hsa049180.62943582
88Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62790845
89Prostate cancer_Homo sapiens_hsa052150.62411511
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62039000
91mRNA surveillance pathway_Homo sapiens_hsa030150.61016626
92Pathways in cancer_Homo sapiens_hsa052000.60677972
93Melanogenesis_Homo sapiens_hsa049160.60571049
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60335058
95Caffeine metabolism_Homo sapiens_hsa002320.60137704
96RNA transport_Homo sapiens_hsa030130.59361310
97AMPK signaling pathway_Homo sapiens_hsa041520.58004814
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57711427
99Fanconi anemia pathway_Homo sapiens_hsa034600.57670987
100Steroid biosynthesis_Homo sapiens_hsa001000.56516478
101Melanoma_Homo sapiens_hsa052180.56131746
102mTOR signaling pathway_Homo sapiens_hsa041500.54786614
103Glutathione metabolism_Homo sapiens_hsa004800.54485457
104Prion diseases_Homo sapiens_hsa050200.54329287
105Axon guidance_Homo sapiens_hsa043600.53813022
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52738096
107Fatty acid elongation_Homo sapiens_hsa000620.52494350
108Circadian rhythm_Homo sapiens_hsa047100.51713901
109p53 signaling pathway_Homo sapiens_hsa041150.51683590
110Linoleic acid metabolism_Homo sapiens_hsa005910.51280862
111Colorectal cancer_Homo sapiens_hsa052100.50979476
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49070889
113Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49015679
114ABC transporters_Homo sapiens_hsa020100.47068229
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46824423
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42968241
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41271478
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41039278
119HTLV-I infection_Homo sapiens_hsa051660.40330150
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36600516

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