ADGRB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.76917385
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.67290523
3locomotory exploration behavior (GO:0035641)6.53410720
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.22459895
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.73081862
6vocalization behavior (GO:0071625)5.69175658
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.47549113
8synaptic vesicle exocytosis (GO:0016079)5.45028466
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.42654092
10glutamate secretion (GO:0014047)5.34438819
11regulation of glutamate receptor signaling pathway (GO:1900449)5.17593456
12regulation of synaptic vesicle exocytosis (GO:2000300)5.06478852
13regulation of neuronal synaptic plasticity (GO:0048168)5.04991368
14regulation of long-term neuronal synaptic plasticity (GO:0048169)4.97525895
15cerebellar granule cell differentiation (GO:0021707)4.85607254
16regulation of synapse structural plasticity (GO:0051823)4.85468949
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.80524517
18protein localization to synapse (GO:0035418)4.75320946
19exploration behavior (GO:0035640)4.75078056
20neurotransmitter secretion (GO:0007269)4.62263823
21layer formation in cerebral cortex (GO:0021819)4.61048479
22dendritic spine morphogenesis (GO:0060997)4.60966697
23amino acid import (GO:0043090)4.58222812
24regulation of synaptic vesicle transport (GO:1902803)4.52444572
25central nervous system myelination (GO:0022010)4.50860352
26axon ensheathment in central nervous system (GO:0032291)4.50860352
27neuronal action potential propagation (GO:0019227)4.43466900
28gamma-aminobutyric acid transport (GO:0015812)4.36390459
29neurotransmitter-gated ion channel clustering (GO:0072578)4.32455066
30positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr4.32389837
31synaptic transmission, glutamatergic (GO:0035249)4.30104694
32neuromuscular process controlling balance (GO:0050885)4.14465693
33long-term memory (GO:0007616)4.13888790
34potassium ion homeostasis (GO:0055075)4.09822305
35glutamate receptor signaling pathway (GO:0007215)4.09500004
36positive regulation of membrane potential (GO:0045838)4.08578008
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.07893133
38regulation of dendritic spine morphogenesis (GO:0061001)4.05144405
39cellular potassium ion homeostasis (GO:0030007)4.04115321
40ovulation cycle (GO:0042698)4.04076271
41neuron cell-cell adhesion (GO:0007158)4.03023650
42regulation of excitatory postsynaptic membrane potential (GO:0060079)4.01587522
43proline transport (GO:0015824)3.97590631
44sodium ion export (GO:0071436)3.97151931
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.94721613
46neuron-neuron synaptic transmission (GO:0007270)3.91979423
47regulation of synaptic plasticity (GO:0048167)3.84865978
48negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.79673036
49glycine transport (GO:0015816)3.79214072
50regulation of postsynaptic membrane potential (GO:0060078)3.78339929
51auditory behavior (GO:0031223)3.76654802
52positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.71362040
53chondroitin sulfate catabolic process (GO:0030207)3.69765215
54prepulse inhibition (GO:0060134)3.68109337
55neuromuscular process controlling posture (GO:0050884)3.67700558
56synaptic vesicle endocytosis (GO:0048488)3.63854531
57neurotransmitter transport (GO:0006836)3.63757726
58dermatan sulfate biosynthetic process (GO:0030208)3.63750389
59positive regulation of synaptic transmission, GABAergic (GO:0032230)3.62956216
60activation of protein kinase A activity (GO:0034199)3.62287894
61regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.60955127
62presynaptic membrane assembly (GO:0097105)3.59211432
63transmission of nerve impulse (GO:0019226)3.59025031
64dermatan sulfate metabolic process (GO:0030205)3.55150570
65positive regulation of synapse maturation (GO:0090129)3.54558525
66regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.54095008
67response to auditory stimulus (GO:0010996)3.53266608
68neuronal ion channel clustering (GO:0045161)3.49302853
69G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.49246013
70presynaptic membrane organization (GO:0097090)3.46964177
71regulation of neurotransmitter secretion (GO:0046928)3.46445076
72regulation of neurotransmitter levels (GO:0001505)3.42444706
73positive regulation of neurotransmitter transport (GO:0051590)3.42294038
74positive regulation of neurotransmitter secretion (GO:0001956)3.41624327
75positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.41226773
76negative regulation of synaptic transmission, GABAergic (GO:0032229)3.40715813
77cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.40083712
78regulation of synaptic transmission, glutamatergic (GO:0051966)3.38618421
79L-amino acid import (GO:0043092)3.37651867
80dendritic spine organization (GO:0097061)3.37225998
81dendrite morphogenesis (GO:0048813)3.35865481
82positive regulation of dendritic spine development (GO:0060999)3.35479484
83cerebellar Purkinje cell differentiation (GO:0021702)3.32361292
84cell communication by electrical coupling (GO:0010644)3.31938241
85regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.31509552
86long-term synaptic potentiation (GO:0060291)3.31185078
87regulation of dendritic spine development (GO:0060998)3.30013059
88cerebellar Purkinje cell layer development (GO:0021680)3.28815951
89neuromuscular process (GO:0050905)3.28679586
90positive regulation of dendritic spine morphogenesis (GO:0061003)3.26466483
91neuron recognition (GO:0008038)3.24530835
92regulation of neurotransmitter transport (GO:0051588)3.24115527
93regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.24097898
94mechanosensory behavior (GO:0007638)3.23460697
95acidic amino acid transport (GO:0015800)3.22663460
96regulation of ARF protein signal transduction (GO:0032012)3.22654903
97regulation of synapse maturation (GO:0090128)3.21412145
98membrane depolarization (GO:0051899)3.20390239
99membrane hyperpolarization (GO:0060081)3.19429514
100cellular sodium ion homeostasis (GO:0006883)3.19385258
101regulation of vesicle fusion (GO:0031338)3.19195164
102learning (GO:0007612)3.16483422
103membrane depolarization during action potential (GO:0086010)3.14813283
104postsynaptic membrane organization (GO:0001941)3.08848698
105tongue development (GO:0043586)3.07122604
106axonal fasciculation (GO:0007413)3.06957520
107positive regulation of synaptic transmission (GO:0050806)3.06900303
108regulation of synaptic transmission (GO:0050804)3.05602631
109establishment of mitochondrion localization (GO:0051654)3.03124142
110response to dietary excess (GO:0002021)3.02972841
111G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.98639192
112negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.98602450
113astrocyte differentiation (GO:0048708)2.98196258
114neurotransmitter uptake (GO:0001504)2.97754660
115chemosensory behavior (GO:0007635)2.96846685
116social behavior (GO:0035176)2.96564240
117intraspecies interaction between organisms (GO:0051703)2.96564240
118visual learning (GO:0008542)2.95898511
119vesicle transport along microtubule (GO:0047496)2.95334727
120behavioral defense response (GO:0002209)2.95016335
121behavioral fear response (GO:0001662)2.95016335
122regulation of beta-amyloid formation (GO:1902003)2.94622104
123cell migration in hindbrain (GO:0021535)2.94477948
124regulation of female receptivity (GO:0045924)2.93554913
125synaptic transmission (GO:0007268)2.89940113
126regulation of voltage-gated calcium channel activity (GO:1901385)2.89936109
127potassium ion import (GO:0010107)2.89877144

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.92287425
2RARB_27405468_Chip-Seq_BRAIN_Mouse3.18578707
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02428777
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98811601
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.96341347
6DROSHA_22980978_ChIP-Seq_HELA_Human2.91734930
7REST_21632747_ChIP-Seq_MESCs_Mouse2.87872857
8GBX2_23144817_ChIP-Seq_PC3_Human2.76974912
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74120952
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74120952
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.68079524
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.67991956
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.54934992
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.54486580
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.53548233
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46853068
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.40997066
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.39301248
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38910051
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37244432
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35783781
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.29624264
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.26895076
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.26335556
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.14325380
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.13503676
27ERG_21242973_ChIP-ChIP_JURKAT_Human2.09908835
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.07989374
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90775366
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90179698
31AR_21572438_ChIP-Seq_LNCaP_Human1.81492850
32RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.60562977
33DNAJC2_21179169_ChIP-ChIP_NT2_Human1.59219901
34KDM2B_26808549_Chip-Seq_K562_Human1.58326223
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.54949478
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50461753
37RING1B_27294783_Chip-Seq_ESCs_Mouse1.46325664
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41854811
39EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39990198
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33706443
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32760883
42EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32648204
43WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31414916
44ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30384937
45SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29897090
46RING1B_27294783_Chip-Seq_NPCs_Mouse1.29053883
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26486454
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26066949
49RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.25922031
50GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25072412
51SMAD4_21799915_ChIP-Seq_A2780_Human1.24929418
52AR_19668381_ChIP-Seq_PC3_Human1.22354308
53CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18566499
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18428294
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.17956658
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.16649045
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16530674
58ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13236546
59P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12506601
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11033489
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10136364
62CTCF_27219007_Chip-Seq_Bcells_Human1.09950160
63EGR1_19032775_ChIP-ChIP_M12_Human1.08843017
64ZNF274_21170338_ChIP-Seq_K562_Hela1.08401860
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07698148
66ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06960360
67TET1_21490601_ChIP-Seq_MESCs_Mouse1.06685752
68P68_20966046_ChIP-Seq_HELA_Human1.05665270
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05033589
70SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04246766
71GATA1_26923725_Chip-Seq_HPCs_Mouse1.04182678
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02630457
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01993932
74STAT3_23295773_ChIP-Seq_U87_Human1.01443064
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.00330517
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00313306
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00206482
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98523842
79NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98181028
80LXR_22292898_ChIP-Seq_THP-1_Human0.97218199
81YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96804666
82SMAD3_21741376_ChIP-Seq_HESCs_Human0.96787425
83ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95643092
84AR_25329375_ChIP-Seq_VCAP_Human0.94000489
85UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93949774
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93461234
87CREB1_26743006_Chip-Seq_LNCaP_Human0.92996469
88SMAD_19615063_ChIP-ChIP_OVARY_Human0.92523758
89DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92416122
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92314777
91TP53_23651856_ChIP-Seq_MEFs_Mouse0.91265818
92RUNX1_26923725_Chip-Seq_HPCs_Mouse0.91121352
93DPY_21335234_ChIP-Seq_ESCs_Mouse0.89075571
94KLF4_19829295_ChIP-Seq_ESCs_Human0.88476972
95SMAD4_21741376_ChIP-Seq_HESCs_Human0.88379422
96TET1_21451524_ChIP-Seq_MESCs_Mouse0.88352799
97TCF4_23295773_ChIP-Seq_U87_Human0.88351642
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88013075
99SMAD3_21741376_ChIP-Seq_ESCs_Human0.87557162
100KDM2B_26808549_Chip-Seq_JURKAT_Human0.87417678
101AHR_22903824_ChIP-Seq_MCF-7_Human0.87132403
102TRIM28_21343339_ChIP-Seq_HEK293_Human0.86724368
103SMC4_20622854_ChIP-Seq_HELA_Human0.86705002
104PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85609798
105ARNT_22903824_ChIP-Seq_MCF-7_Human0.85195063
106OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83747860
107KDM2B_26808549_Chip-Seq_DND41_Human0.82924055
108ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82884851
109SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82859292
110POU5F1_16518401_ChIP-PET_MESCs_Mouse0.82836406
111RXR_22108803_ChIP-Seq_LS180_Human0.82386130
112CBX2_27304074_Chip-Seq_ESCs_Mouse0.81664044
113OCT4_19829295_ChIP-Seq_ESCs_Human0.81640061
114TP53_20018659_ChIP-ChIP_R1E_Mouse0.81480706
115TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.80812113
116SOX3_22085726_ChIP-Seq_NPCs_Mouse0.79529920
117TP53_16413492_ChIP-PET_HCT116_Human0.78442762
118TCF7_22412390_ChIP-Seq_EML_Mouse0.78183537
119P300_19829295_ChIP-Seq_ESCs_Human0.77718505
120MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.76989366
121CTNNB1_20460455_ChIP-Seq_HCT116_Human0.76460512
122TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.75810205
123NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.75276641
124TOP2B_26459242_ChIP-Seq_MCF-7_Human0.74253775
125SA1_27219007_Chip-Seq_ERYTHROID_Human0.73894734
126SMAD4_21741376_ChIP-Seq_ESCs_Human0.71104875
127MYC_19915707_ChIP-ChIP_AK7_Human0.71065483
128KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.70812245

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.55747150
2MP0009379_abnormal_foot_pigmentation5.62931012
3MP0003880_abnormal_central_pattern4.48775543
4MP0003635_abnormal_synaptic_transmissio4.41754912
5MP0002822_catalepsy3.84814506
6MP0004270_analgesia3.80621515
7MP0009745_abnormal_behavioral_response3.57545500
8MP0002063_abnormal_learning/memory/cond3.55516131
9MP0002064_seizures3.30668740
10MP0009046_muscle_twitch3.16621773
11MP0005423_abnormal_somatic_nervous3.06627184
12MP0002572_abnormal_emotion/affect_behav2.87067017
13MP0001968_abnormal_touch/_nociception2.72888480
14MP0001486_abnormal_startle_reflex2.70211041
15MP0002272_abnormal_nervous_system2.58004303
16MP0002734_abnormal_mechanical_nocicepti2.50694356
17MP0001501_abnormal_sleep_pattern2.22400895
18MP0000579_abnormal_nail_morphology2.17227734
19MP0008569_lethality_at_weaning2.09493456
20MP0002733_abnormal_thermal_nociception1.98150378
21MP0009780_abnormal_chondrocyte_physiolo1.96442900
22MP0001970_abnormal_pain_threshold1.95020729
23MP0001440_abnormal_grooming_behavior1.93806764
24MP0004858_abnormal_nervous_system1.93211095
25MP0004811_abnormal_neuron_physiology1.92883242
26MP0002736_abnormal_nociception_after1.90951118
27MP0002909_abnormal_adrenal_gland1.81655508
28MP0003329_amyloid_beta_deposits1.78834451
29MP0002067_abnormal_sensory_capabilities1.76912565
30MP0002735_abnormal_chemical_nociception1.76326428
31MP0004885_abnormal_endolymph1.72876501
32MP0002557_abnormal_social/conspecific_i1.71333838
33MP0005646_abnormal_pituitary_gland1.69434524
34MP0000778_abnormal_nervous_system1.69245093
35MP0005386_behavior/neurological_phenoty1.67963456
36MP0004924_abnormal_behavior1.67963456
37MP0000955_abnormal_spinal_cord1.63438743
38MP0003879_abnormal_hair_cell1.60826319
39MP0002184_abnormal_innervation1.60799155
40MP0009384_cardiac_valve_regurgitation1.57312027
41MP0003633_abnormal_nervous_system1.54155812
42MP0002066_abnormal_motor_capabilities/c1.45434355
43MP0002882_abnormal_neuron_morphology1.43021943
44MP0003283_abnormal_digestive_organ1.42869879
45MP0003075_altered_response_to1.35808942
46MP0003787_abnormal_imprinting1.31277315
47MP0003123_paternal_imprinting1.29996832
48MP0003631_nervous_system_phenotype1.25902017
49MP0001984_abnormal_olfaction1.25802929
50MP0005645_abnormal_hypothalamus_physiol1.25574746
51MP0001502_abnormal_circadian_rhythm1.24441581
52MP0004142_abnormal_muscle_tone1.22644753
53MP0002152_abnormal_brain_morphology1.14763450
54MP0003690_abnormal_glial_cell1.14168041
55MP0008872_abnormal_physiological_respon1.11709375
56MP0008961_abnormal_basal_metabolism1.11533323
57MP0000569_abnormal_digit_pigmentation1.08717250
58MP0001177_atelectasis1.07800596
59MP0003136_yellow_coat_color1.07321229
60MP0005167_abnormal_blood-brain_barrier1.06726283
61MP0001529_abnormal_vocalization1.06059185
62MP0008874_decreased_physiological_sensi1.05800911
63MP0001905_abnormal_dopamine_level0.98959377
64MP0002249_abnormal_larynx_morphology0.98780436
65MP0000751_myopathy0.97952969
66MP0002069_abnormal_eating/drinking_beha0.95724534
67MP0000920_abnormal_myelination0.90869629
68MP0002229_neurodegeneration0.90706443
69MP0003634_abnormal_glial_cell0.90394109
70MP0006276_abnormal_autonomic_nervous0.89019018
71MP0004233_abnormal_muscle_weight0.87706804
72MP0003632_abnormal_nervous_system0.85383801
73MP0000383_abnormal_hair_follicle0.84140189
74MP0003172_abnormal_lysosome_physiology0.83046775
75MP0000026_abnormal_inner_ear0.78833394
76MP0005394_taste/olfaction_phenotype0.75784815
77MP0005499_abnormal_olfactory_system0.75784815
78MP0005535_abnormal_body_temperature0.75783544
79MP0004085_abnormal_heartbeat0.75757587
80MP0003137_abnormal_impulse_conducting0.75744874
81MP0003122_maternal_imprinting0.75239254
82MP0000604_amyloidosis0.74953794
83MP0004145_abnormal_muscle_electrophysio0.74784863
84MP0000013_abnormal_adipose_tissue0.74127688
85MP0005166_decreased_susceptibility_to0.73108648
86MP0003183_abnormal_peptide_metabolism0.72254345
87MP0001485_abnormal_pinna_reflex0.71191855
88MP0005551_abnormal_eye_electrophysiolog0.70707467
89MP0002090_abnormal_vision0.70327640
90MP0003938_abnormal_ear_development0.69394563
91MP0010234_abnormal_vibrissa_follicle0.68419572
92MP0001963_abnormal_hearing_physiology0.66586919
93MP0000631_abnormal_neuroendocrine_gland0.64924142
94MP0005623_abnormal_meninges_morphology0.64874986
95MP0002752_abnormal_somatic_nervous0.63838246
96MP0001188_hyperpigmentation0.62969097
97MP0004742_abnormal_vestibular_system0.62383204
98MP0005409_darkened_coat_color0.62070482
99MP0003861_abnormal_nervous_system0.59436051
100MP0010769_abnormal_survival0.59088173
101MP0002653_abnormal_ependyma_morphology0.58801335
102MP0001664_abnormal_digestion0.58241848
103MP0002638_abnormal_pupillary_reflex0.58102890
104MP0004510_myositis0.57411395
105MP0001943_abnormal_respiration0.57189228
106MP0000467_abnormal_esophagus_morphology0.56268412
107MP0010768_mortality/aging0.55916917
108MP0005171_absent_coat_pigmentation0.55063381
109MP0002082_postnatal_lethality0.54331162
110MP0010770_preweaning_lethality0.54331162
111MP0002089_abnormal_postnatal_growth/wei0.52610863
112MP0003956_abnormal_body_size0.52006125
113MP0001348_abnormal_lacrimal_gland0.50942581
114MP0005388_respiratory_system_phenotype0.50731160
115MP0002133_abnormal_respiratory_system0.50731160
116MP0010678_abnormal_skin_adnexa0.49311155
117MP0000762_abnormal_tongue_morphology0.48184728
118MP0003045_fibrosis0.47282266
119MP0004130_abnormal_muscle_cell0.46261338

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.03286511
2Focal motor seizures (HP:0011153)7.33877705
3Focal seizures (HP:0007359)5.75066047
4Visual hallucinations (HP:0002367)5.20833794
5Epileptic encephalopathy (HP:0200134)4.49448999
6Action tremor (HP:0002345)4.27203117
7Febrile seizures (HP:0002373)4.09515593
8Progressive cerebellar ataxia (HP:0002073)4.08459523
9Atonic seizures (HP:0010819)3.99272947
10Ankle clonus (HP:0011448)3.92212572
11Absence seizures (HP:0002121)3.75283800
12Supranuclear gaze palsy (HP:0000605)3.71638295
13Peripheral hypomyelination (HP:0007182)3.71609385
14Poor eye contact (HP:0000817)3.67386299
15Generalized tonic-clonic seizures (HP:0002069)3.64980062
16Impaired vibration sensation in the lower limbs (HP:0002166)3.52853148
17Annular pancreas (HP:0001734)3.49618692
18Dialeptic seizures (HP:0011146)3.43607327
19Dysdiadochokinesis (HP:0002075)3.43042404
20Depression (HP:0000716)3.41109382
21Abnormality of the lower motor neuron (HP:0002366)3.38713225
22Urinary bladder sphincter dysfunction (HP:0002839)3.38052666
23Broad-based gait (HP:0002136)3.37987971
24Postural instability (HP:0002172)3.36584514
25Impaired social interactions (HP:0000735)3.35170278
26Abnormal social behavior (HP:0012433)3.35170278
27Gaze-evoked nystagmus (HP:0000640)3.31489295
28Split foot (HP:0001839)3.26832536
29Dysmetria (HP:0001310)3.24438910
30Papilledema (HP:0001085)3.23752398
31Hyperacusis (HP:0010780)3.22477507
32Torticollis (HP:0000473)3.10120476
33Mutism (HP:0002300)3.07383788
34Anxiety (HP:0000739)3.06802500
35Genetic anticipation (HP:0003743)2.99951117
36Sleep apnea (HP:0010535)2.98152510
37Intention tremor (HP:0002080)2.90781501
38Overriding aorta (HP:0002623)2.90337661
39Hemiplegia (HP:0002301)2.88869857
40Abnormal eating behavior (HP:0100738)2.86765956
41Elfin facies (HP:0004428)2.85771740
42Impaired smooth pursuit (HP:0007772)2.84871991
43Focal dystonia (HP:0004373)2.82332557
44Urinary urgency (HP:0000012)2.82102382
45Truncal ataxia (HP:0002078)2.75217611
46Ventricular fibrillation (HP:0001663)2.70591174
47Akinesia (HP:0002304)2.69302312
48Megalencephaly (HP:0001355)2.69033657
49Spastic gait (HP:0002064)2.67490821
50Hemiparesis (HP:0001269)2.65764263
51Stereotypic behavior (HP:0000733)2.63823135
52Amblyopia (HP:0000646)2.59402496
53Scanning speech (HP:0002168)2.57556023
54Pointed chin (HP:0000307)2.56841293
55Bradykinesia (HP:0002067)2.56039844
56Craniofacial dystonia (HP:0012179)2.51811516
57Cerebral hypomyelination (HP:0006808)2.50459467
58Abnormality of ocular smooth pursuit (HP:0000617)2.47148287
59Insomnia (HP:0100785)2.46621068
60Increased circulating renin level (HP:0000848)2.44361814
61Dysmetric saccades (HP:0000641)2.43944029
62Impaired vibratory sensation (HP:0002495)2.43037327
63Status epilepticus (HP:0002133)2.41735301
64Diminished motivation (HP:0000745)2.41386517
65Diplopia (HP:0000651)2.37333189
66Abnormality of binocular vision (HP:0011514)2.37333189
67Abnormality of the diencephalon (HP:0010662)2.37207256
68Neurofibrillary tangles (HP:0002185)2.36079786
69Obstructive sleep apnea (HP:0002870)2.35363420
70Renovascular hypertension (HP:0100817)2.29932194
71Bundle branch block (HP:0011710)2.29393180
72Clonus (HP:0002169)2.27059667
73Cerebral inclusion bodies (HP:0100314)2.25201357
74Lower limb muscle weakness (HP:0007340)2.24601676
75Drooling (HP:0002307)2.24026074
76Excessive salivation (HP:0003781)2.24026074
77Delusions (HP:0000746)2.21338338
78Ankyloglossia (HP:0010296)2.17488769
79Polyphagia (HP:0002591)2.16797441
80Hyperventilation (HP:0002883)2.16742057
81Fetal akinesia sequence (HP:0001989)2.16172331
82Progressive inability to walk (HP:0002505)2.15773214
83Epileptiform EEG discharges (HP:0011182)2.14124897
84Lower limb amyotrophy (HP:0007210)2.13777255
85Resting tremor (HP:0002322)2.10276123
86Spastic tetraparesis (HP:0001285)2.08527819
87EEG with generalized epileptiform discharges (HP:0011198)2.07413146
88Abnormality of the periventricular white matter (HP:0002518)2.05714050
89Bronchomalacia (HP:0002780)2.05098121
90Abnormal EKG (HP:0003115)2.02858560
91Hypsarrhythmia (HP:0002521)2.02705517
92Renal duplication (HP:0000075)2.02528941
93Bowel incontinence (HP:0002607)2.01381884
94Incomplete penetrance (HP:0003829)2.00898104
95Flat cornea (HP:0007720)1.98912589
96Generalized myoclonic seizures (HP:0002123)1.97832838
97Urethral obstruction (HP:0000796)1.96869102
98Termporal pattern (HP:0011008)1.93318457
99Insidious onset (HP:0003587)1.93318457
100Hyperparathyroidism (HP:0000843)1.92914861
101Anomalous pulmonary venous return (HP:0010772)1.91068961
102Morphological abnormality of the inner ear (HP:0011390)1.90387293
103Neuronal loss in central nervous system (HP:0002529)1.89896469
104Abnormality of the corticospinal tract (HP:0002492)1.89318528
105Aplasia involving bones of the upper limbs (HP:0009823)1.88886463
106Aplasia of the phalanges of the hand (HP:0009802)1.88886463
107Aplasia involving bones of the extremities (HP:0009825)1.88886463
108Shallow orbits (HP:0000586)1.88156347
109Abnormality of saccadic eye movements (HP:0000570)1.88114408
110Turricephaly (HP:0000262)1.83933310
111Abnormal large intestine physiology (HP:0012700)1.83396930
112Tetraplegia (HP:0002445)1.83356633
113Choreoathetosis (HP:0001266)1.82863584
114Absent speech (HP:0001344)1.82403217
115Rigidity (HP:0002063)1.82229440
116Dementia (HP:0000726)1.81336627
117Limb dystonia (HP:0002451)1.78941203
118Megalocornea (HP:0000485)1.78313235
119Rapidly progressive (HP:0003678)1.76850333
120Gait ataxia (HP:0002066)1.76772365
121Apathy (HP:0000741)1.76309924
122Lower limb asymmetry (HP:0100559)1.76036650
123Aqueductal stenosis (HP:0002410)1.69942568
124Amyotrophic lateral sclerosis (HP:0007354)1.69905506
125Prolonged QT interval (HP:0001657)1.68696030
126Agitation (HP:0000713)1.68227272
127Pheochromocytoma (HP:0002666)1.65897663
128Inappropriate behavior (HP:0000719)1.63367881

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.07018570
2NTRK34.30706499
3MAP3K94.10878177
4ERBB44.10534518
5PKN12.88658189
6DAPK22.87485920
7PRKD32.78539533
8MARK12.74983180
9MINK12.48542942
10PAK62.47590267
11MAP3K42.45719384
12NTRK22.25923612
13KSR22.21655999
14CAMKK12.13814291
15DAPK11.92627784
16NTRK11.87899503
17TYRO31.85398207
18MAP2K71.84173682
19STK381.65002859
20TNIK1.64798105
21CDK51.61290085
22ERBB21.54518427
23RIPK41.54211384
24TAOK11.53116826
25KSR11.49761764
26UHMK11.46915922
27PRPF4B1.44754669
28MAP2K41.42074931
29SIK21.41042269
30PINK11.30327936
31FES1.21510111
32MAP3K131.19500883
33MAP3K21.14283778
34CDK191.12443966
35ALK1.10942496
36GRK51.07601949
37PRKCG1.07203145
38ARAF1.07087188
39PHKG21.06412437
40PHKG11.06412437
41MAPK111.05952027
42LATS21.05691831
43ICK1.05582868
44MAPK131.03958942
45PRKCH1.01276497
46STK111.00412519
47CAMK11.00410746
48DDR20.98339742
49PLK20.98191345
50CDK150.94264467
51MAP3K120.93369704
52CDK180.92843006
53RIPK10.89419837
54MARK20.88860649
55RAF10.87950847
56CAMKK20.86199216
57MAPK120.84089805
58CDK140.83945045
59CAMK2A0.83527459
60CDK11A0.83359850
61SGK2230.81058466
62SGK4940.81058466
63LMTK20.79585496
64TRIB30.79382715
65JAK20.77444028
66CDC42BPA0.77080090
67MAP3K60.75226271
68SGK30.74521859
69SGK10.73756296
70RET0.73030739
71TNK20.72132110
72CAMK2B0.71408759
73MAPK150.70599382
74ROCK20.69399234
75FGFR20.68126637
76PDK10.66878718
77PRKD20.66449906
78BMX0.66128814
79SGK20.64829547
80PDPK10.62594522
81PNCK0.61068191
82BRSK10.60976840
83FGR0.60565303
84MAP3K110.60513989
85PAK30.60363391
86NEK10.59622322
87RPS6KA30.57906338
88PTK2B0.55442634
89NEK60.55403122
90CAMK40.54103500
91MAP3K70.53448771
92PRKCZ0.53103261
93CSNK1G20.52736340
94MAP3K10.52685350
95ROCK10.52367649
96PDGFRA0.51602508
97DYRK1A0.51208012
98MAPK100.50331699
99DMPK0.48505503
100CAMK1G0.46078236
101FYN0.45956492
102DAPK30.45061668
103OXSR10.44219525
104SCYL20.44214334
105CASK0.43679062
106CAMK2G0.42485591
107MAP2K60.39002195
108BMPR20.38842130
109DYRK20.37770444
110CAMK1D0.34929415
111TESK10.34563290
112CAMK2D0.33277005
113BRAF0.32435634
114SRC0.31678431
115WNK10.30887484
116IRAK20.29287412
117MAPK80.29110409
118PRKCB0.28912056
119MAP2K10.28639337
120MAPK40.28417702
121LIMK10.27242250

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.34500695
2Synaptic vesicle cycle_Homo sapiens_hsa047213.14845089
3Olfactory transduction_Homo sapiens_hsa047403.00843283
4Circadian entrainment_Homo sapiens_hsa047132.72557735
5GABAergic synapse_Homo sapiens_hsa047272.69443305
6Glutamatergic synapse_Homo sapiens_hsa047242.61709650
7Long-term potentiation_Homo sapiens_hsa047202.60244843
8Morphine addiction_Homo sapiens_hsa050322.47126735
9Amphetamine addiction_Homo sapiens_hsa050312.45969946
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.43117826
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.25450761
12Salivary secretion_Homo sapiens_hsa049702.17015292
13Dopaminergic synapse_Homo sapiens_hsa047282.11582623
14Insulin secretion_Homo sapiens_hsa049111.99865592
15Nitrogen metabolism_Homo sapiens_hsa009101.96473558
16Gastric acid secretion_Homo sapiens_hsa049711.96061878
17Cholinergic synapse_Homo sapiens_hsa047251.94760698
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.93263336
19Cocaine addiction_Homo sapiens_hsa050301.74771853
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.74543101
21Oxytocin signaling pathway_Homo sapiens_hsa049211.68619972
22Long-term depression_Homo sapiens_hsa047301.56777088
23Calcium signaling pathway_Homo sapiens_hsa040201.56388901
24Renin secretion_Homo sapiens_hsa049241.56044007
25GnRH signaling pathway_Homo sapiens_hsa049121.51706353
26Taste transduction_Homo sapiens_hsa047421.44853731
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43217100
28Gap junction_Homo sapiens_hsa045401.40787333
29Serotonergic synapse_Homo sapiens_hsa047261.39949761
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.38136274
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34929680
32cAMP signaling pathway_Homo sapiens_hsa040241.33099592
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31865065
34Vitamin B6 metabolism_Homo sapiens_hsa007501.26595964
35Glioma_Homo sapiens_hsa052141.25192408
36Type II diabetes mellitus_Homo sapiens_hsa049301.24643972
37Estrogen signaling pathway_Homo sapiens_hsa049151.17932727
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13292844
39ErbB signaling pathway_Homo sapiens_hsa040121.11933728
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10617592
41Notch signaling pathway_Homo sapiens_hsa043301.08105974
42Melanogenesis_Homo sapiens_hsa049161.06013262
43Axon guidance_Homo sapiens_hsa043601.05379403
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00041794
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98203589
46Dorso-ventral axis formation_Homo sapiens_hsa043200.97191593
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.95275774
48Oocyte meiosis_Homo sapiens_hsa041140.95072724
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.87561721
50Pancreatic secretion_Homo sapiens_hsa049720.81663285
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81326451
52Collecting duct acid secretion_Homo sapiens_hsa049660.80818047
53Choline metabolism in cancer_Homo sapiens_hsa052310.79461444
54Thyroid hormone synthesis_Homo sapiens_hsa049180.77872334
55mTOR signaling pathway_Homo sapiens_hsa041500.76190668
56VEGF signaling pathway_Homo sapiens_hsa043700.75615835
57MAPK signaling pathway_Homo sapiens_hsa040100.75264093
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74793653
59Cardiac muscle contraction_Homo sapiens_hsa042600.74031026
60Dilated cardiomyopathy_Homo sapiens_hsa054140.73252461
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71619472
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.71379795
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68677149
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68518681
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68187054
66Fatty acid biosynthesis_Homo sapiens_hsa000610.67170881
67Rap1 signaling pathway_Homo sapiens_hsa040150.65635318
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64936776
69Circadian rhythm_Homo sapiens_hsa047100.62778995
70Bile secretion_Homo sapiens_hsa049760.62386750
71Endocytosis_Homo sapiens_hsa041440.61125361
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60495120
73Phototransduction_Homo sapiens_hsa047440.59845443
74Ras signaling pathway_Homo sapiens_hsa040140.58232638
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.57092340
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56914313
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56773145
78Non-small cell lung cancer_Homo sapiens_hsa052230.56671165
79Endometrial cancer_Homo sapiens_hsa052130.54448799
80Glucagon signaling pathway_Homo sapiens_hsa049220.54163557
81Alcoholism_Homo sapiens_hsa050340.52686838
82Type I diabetes mellitus_Homo sapiens_hsa049400.50092919
83Wnt signaling pathway_Homo sapiens_hsa043100.49846173
84Vibrio cholerae infection_Homo sapiens_hsa051100.48452605
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47536641
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46840830
87Inositol phosphate metabolism_Homo sapiens_hsa005620.46563813
88Insulin signaling pathway_Homo sapiens_hsa049100.44878349
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44844757
90Prion diseases_Homo sapiens_hsa050200.44028427
91Chemokine signaling pathway_Homo sapiens_hsa040620.42854929
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.42184246
93HIF-1 signaling pathway_Homo sapiens_hsa040660.39983681
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39829419
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39298444
96Renal cell carcinoma_Homo sapiens_hsa052110.38754398
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38443077
98Arginine biosynthesis_Homo sapiens_hsa002200.36068081
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34153325
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33605427
101Bladder cancer_Homo sapiens_hsa052190.32803711
102Ovarian steroidogenesis_Homo sapiens_hsa049130.32794456
103AMPK signaling pathway_Homo sapiens_hsa041520.32382381
104Prolactin signaling pathway_Homo sapiens_hsa049170.31332734
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30919467
106Pancreatic cancer_Homo sapiens_hsa052120.30495895
107Colorectal cancer_Homo sapiens_hsa052100.29077691
108Tight junction_Homo sapiens_hsa045300.28052802
109Melanoma_Homo sapiens_hsa052180.27736905
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27400306
111Hippo signaling pathway_Homo sapiens_hsa043900.26869097
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25407112

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