ADGRB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.77003259
2locomotory exploration behavior (GO:0035641)6.65520467
3regulation of short-term neuronal synaptic plasticity (GO:0048172)6.63934675
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.31608404
5vocalization behavior (GO:0071625)5.71505763
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.70815593
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.66340024
8synaptic vesicle docking involved in exocytosis (GO:0016081)5.49983908
9regulation of glutamate receptor signaling pathway (GO:1900449)5.38553408
10synaptic vesicle exocytosis (GO:0016079)5.35933921
11glutamate secretion (GO:0014047)5.33571788
12regulation of neuronal synaptic plasticity (GO:0048168)5.18002282
13regulation of synaptic vesicle exocytosis (GO:2000300)5.05187827
14regulation of long-term neuronal synaptic plasticity (GO:0048169)5.01521055
15regulation of synapse structural plasticity (GO:0051823)5.00369983
16exploration behavior (GO:0035640)4.96909269
17dendritic spine morphogenesis (GO:0060997)4.88504272
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.84478370
19protein localization to synapse (GO:0035418)4.83172050
20layer formation in cerebral cortex (GO:0021819)4.64483921
21regulation of synaptic vesicle transport (GO:1902803)4.53204468
22neurotransmitter secretion (GO:0007269)4.50006567
23cerebellar granule cell differentiation (GO:0021707)4.49189588
24neuronal action potential propagation (GO:0019227)4.48238051
25synaptic transmission, glutamatergic (GO:0035249)4.40374068
26neurotransmitter-gated ion channel clustering (GO:0072578)4.38062638
27amino acid import (GO:0043090)4.30178376
28long-term memory (GO:0007616)4.20854028
29positive regulation of membrane potential (GO:0045838)4.16093151
30regulation of dendritic spine morphogenesis (GO:0061001)4.13397298
31regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.10502698
32membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.09747360
33neuron cell-cell adhesion (GO:0007158)4.09314020
34glutamate receptor signaling pathway (GO:0007215)4.08889003
35regulation of excitatory postsynaptic membrane potential (GO:0060079)4.01333714
36neuromuscular process controlling balance (GO:0050885)3.95670270
37gamma-aminobutyric acid transport (GO:0015812)3.94227381
38neuron-neuron synaptic transmission (GO:0007270)3.93596890
39regulation of synaptic plasticity (GO:0048167)3.92805581
40proline transport (GO:0015824)3.92138257
41cellular potassium ion homeostasis (GO:0030007)3.87623887
42sodium ion export (GO:0071436)3.86309967
43negative regulation of synaptic transmission, GABAergic (GO:0032229)3.80825636
44positive regulation of synapse maturation (GO:0090129)3.77996149
45positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.75370061
46regulation of postsynaptic membrane potential (GO:0060078)3.75271673
47auditory behavior (GO:0031223)3.69843741
48activation of protein kinase A activity (GO:0034199)3.67875574
49dendritic spine organization (GO:0097061)3.66834226
50G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.66723460
51regulation of voltage-gated calcium channel activity (GO:1901385)3.65733103
52negative regulation of dendrite morphogenesis (GO:0050774)3.62838480
53positive regulation of synaptic transmission, GABAergic (GO:0032230)3.60433377
54potassium ion homeostasis (GO:0055075)3.59135006
55cell migration in hindbrain (GO:0021535)3.57511294
56neuronal ion channel clustering (GO:0045161)3.54158631
57cytoskeletal anchoring at plasma membrane (GO:0007016)3.53654911
58prepulse inhibition (GO:0060134)3.52414094
59neurotransmitter transport (GO:0006836)3.52330246
60transmission of nerve impulse (GO:0019226)3.46760943
61axon ensheathment in central nervous system (GO:0032291)3.45826852
62central nervous system myelination (GO:0022010)3.45826852
63presynaptic membrane assembly (GO:0097105)3.44757792
64response to auditory stimulus (GO:0010996)3.43774951
65L-amino acid import (GO:0043092)3.43604898
66regulation of neurotransmitter secretion (GO:0046928)3.43239561
67positive regulation of neurotransmitter secretion (GO:0001956)3.43000863
68neuron recognition (GO:0008038)3.41375968
69long-term synaptic potentiation (GO:0060291)3.40756211
70positive regulation of dendritic spine development (GO:0060999)3.40219224
71regulation of synaptic transmission, glutamatergic (GO:0051966)3.38915035
72positive regulation of neurotransmitter transport (GO:0051590)3.38757826
73cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.38643149
74presynaptic membrane organization (GO:0097090)3.37946971
75regulation of ARF protein signal transduction (GO:0032012)3.37679789
76regulation of dendritic spine development (GO:0060998)3.37479688
77regulation of synapse maturation (GO:0090128)3.37157571
78dendrite morphogenesis (GO:0048813)3.36890594
79cell communication by electrical coupling (GO:0010644)3.36275178
80glycine transport (GO:0015816)3.36242176
81synaptic vesicle endocytosis (GO:0048488)3.36029532
82regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.34078204
83regulation of neurotransmitter levels (GO:0001505)3.32434289
84regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.31464935
85potassium ion import (GO:0010107)3.31013950
86axonal fasciculation (GO:0007413)3.29760044
87positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.29374885
88positive regulation of dendritic spine morphogenesis (GO:0061003)3.26562903
89regulation of vesicle fusion (GO:0031338)3.22261223
90regulation of neurotransmitter transport (GO:0051588)3.21275377
91innervation (GO:0060384)3.20139567
92membrane depolarization (GO:0051899)3.17866043
93neuromuscular process controlling posture (GO:0050884)3.17618949
94learning (GO:0007612)3.13805588
95postsynaptic membrane organization (GO:0001941)3.13531065
96establishment of mitochondrion localization (GO:0051654)3.11727638
97regulation of synaptic transmission (GO:0050804)3.08804616
98positive regulation of dendrite development (GO:1900006)3.08658460
99membrane hyperpolarization (GO:0060081)3.08503423
100positive regulation of synaptic transmission (GO:0050806)3.08457209
101neuromuscular process (GO:0050905)3.08394942
102behavioral fear response (GO:0001662)3.07753327
103behavioral defense response (GO:0002209)3.07753327
104chemosensory behavior (GO:0007635)3.07637091
105membrane depolarization during action potential (GO:0086010)3.06870970
106cerebellar Purkinje cell differentiation (GO:0021702)3.06657867
107vesicle transport along microtubule (GO:0047496)3.04762255
108acidic amino acid transport (GO:0015800)3.03550743
109regulation of dendrite morphogenesis (GO:0048814)3.03501659
110regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.01020869
111intraspecies interaction between organisms (GO:0051703)2.99106135
112social behavior (GO:0035176)2.99106135
113negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.98359179
114regulation of female receptivity (GO:0045924)2.94974632
115neuromuscular synaptic transmission (GO:0007274)2.94174842
116cerebellar Purkinje cell layer development (GO:0021680)2.93628408
117regulation of dendrite development (GO:0050773)2.88585671
118visual learning (GO:0008542)2.88189040
119cellular sodium ion homeostasis (GO:0006883)2.88025622
120synaptic transmission (GO:0007268)2.87392114
121establishment of nucleus localization (GO:0040023)2.86927866
122gamma-aminobutyric acid signaling pathway (GO:0007214)2.84473140
123cell communication involved in cardiac conduction (GO:0086065)2.79763519

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.07788755
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.16368984
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14057149
4RARB_27405468_Chip-Seq_BRAIN_Mouse3.13593053
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08766293
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.89972628
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.89972628
8DROSHA_22980978_ChIP-Seq_HELA_Human2.89561905
9REST_21632747_ChIP-Seq_MESCs_Mouse2.82541701
10GBX2_23144817_ChIP-Seq_PC3_Human2.81405506
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.80412705
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.62598222
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62413221
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.60764535
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.54742908
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54667425
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.54533011
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.49469050
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47613837
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.41832174
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.37953518
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.36011552
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.34669837
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.30062333
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.24432696
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.13230178
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01024508
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90078811
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.89972541
30AR_21572438_ChIP-Seq_LNCaP_Human1.77968963
31DNAJC2_21179169_ChIP-ChIP_NT2_Human1.54913569
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.51331068
33KDM2B_26808549_Chip-Seq_K562_Human1.50445556
34RING1B_27294783_Chip-Seq_ESCs_Mouse1.50198636
35RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.47913301
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46706152
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42958587
38WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41993839
39EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.38238631
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34019261
41WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32623916
42EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30943929
43SMAD4_21799915_ChIP-Seq_A2780_Human1.30910335
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30662771
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.30417019
46TRIM28_21343339_ChIP-Seq_HEK293_Human1.28981527
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27069320
48RING1B_27294783_Chip-Seq_NPCs_Mouse1.25822838
49SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23925079
50GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23597655
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22904143
52AR_19668381_ChIP-Seq_PC3_Human1.22044384
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.21351808
54ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20954294
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18554866
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18505243
57GATA1_26923725_Chip-Seq_HPCs_Mouse1.16653485
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16139810
59ZNF274_21170338_ChIP-Seq_K562_Hela1.15496882
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15241364
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.14900363
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14439545
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08694054
64TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08299299
65RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08065935
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.05467536
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05275663
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04208393
69P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04144028
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03439140
71CTCF_27219007_Chip-Seq_Bcells_Human1.03131505
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02146368
73KDM2B_26808549_Chip-Seq_DND41_Human1.01784690
74STAT3_23295773_ChIP-Seq_U87_Human1.01517055
75AR_25329375_ChIP-Seq_VCAP_Human1.00250387
76YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99540871
77SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99303938
78SMAD3_21741376_ChIP-Seq_HESCs_Human0.97514972
79TET1_21490601_ChIP-Seq_MESCs_Mouse0.96948541
80SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96846025
81RNF2_27304074_Chip-Seq_NSC_Mouse0.96075211
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95961994
83UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95769483
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94808911
85DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94710028
86SMAD_19615063_ChIP-ChIP_OVARY_Human0.93778671
87CREB1_26743006_Chip-Seq_LNCaP_Human0.93261337
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93043117
89SMAD4_21741376_ChIP-Seq_HESCs_Human0.91315136
90ARNT_22903824_ChIP-Seq_MCF-7_Human0.91090169
91SMAD3_21741376_ChIP-Seq_ESCs_Human0.90965766
92CBX2_27304074_Chip-Seq_ESCs_Mouse0.90429535
93AHR_22903824_ChIP-Seq_MCF-7_Human0.88866516
94OCT4_19829295_ChIP-Seq_ESCs_Human0.88578940
95P300_19829295_ChIP-Seq_ESCs_Human0.87602084
96SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87487270
97TCF4_23295773_ChIP-Seq_U87_Human0.86775371
98ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86756956
99TP53_23651856_ChIP-Seq_MEFs_Mouse0.86495996
100RUNX1_26923725_Chip-Seq_HPCs_Mouse0.86221357
101CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85766410
102RXR_22108803_ChIP-Seq_LS180_Human0.85488496
103SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85235905
104LXR_22292898_ChIP-Seq_THP-1_Human0.84755830
105DPY_21335234_ChIP-Seq_ESCs_Mouse0.84736922
106KLF4_19829295_ChIP-Seq_ESCs_Human0.84728860
107TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84568843
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84267443
109NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83573790
110OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83557047
111TAF15_26573619_Chip-Seq_HEK293_Human0.83418654
112KDM2B_26808549_Chip-Seq_JURKAT_Human0.83409711
113SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82718571
114TP53_16413492_ChIP-PET_HCT116_Human0.81919039
115TP53_20018659_ChIP-ChIP_R1E_Mouse0.81398075
116SMC4_20622854_ChIP-Seq_HELA_Human0.80786696
117ISL1_27105846_Chip-Seq_CPCs_Mouse0.80726530
118ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.79554933
119TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.79478899
120CDX2_19796622_ChIP-Seq_MESCs_Mouse0.79281720
121PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79010692
122TET1_21451524_ChIP-Seq_MESCs_Mouse0.78073879
123P68_20966046_ChIP-Seq_HELA_Human0.77555803
124MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.76169580
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75614265
126SOX3_22085726_ChIP-Seq_NPCs_Mouse0.74965732
127SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.73823821
128ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73312276
129CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.73131066
130SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.71232090
131SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.70749373

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.88586563
2MP0003880_abnormal_central_pattern4.66023517
3MP0003635_abnormal_synaptic_transmissio4.46485486
4MP0004270_analgesia3.85648404
5MP0002822_catalepsy3.70603767
6MP0002063_abnormal_learning/memory/cond3.58483450
7MP0009745_abnormal_behavioral_response3.57037011
8MP0002064_seizures3.24764697
9MP0005423_abnormal_somatic_nervous2.95137784
10MP0009046_muscle_twitch2.88488169
11MP0002572_abnormal_emotion/affect_behav2.80665849
12MP0001968_abnormal_touch/_nociception2.70344675
13MP0001486_abnormal_startle_reflex2.66006323
14MP0002272_abnormal_nervous_system2.51320256
15MP0002734_abnormal_mechanical_nocicepti2.51054467
16MP0001501_abnormal_sleep_pattern2.20219651
17MP0004858_abnormal_nervous_system2.15811356
18MP0009780_abnormal_chondrocyte_physiolo2.14536079
19MP0008569_lethality_at_weaning2.02536920
20MP0004811_abnormal_neuron_physiology1.95082772
21MP0002736_abnormal_nociception_after1.93497090
22MP0001440_abnormal_grooming_behavior1.91033610
23MP0003329_amyloid_beta_deposits1.87377188
24MP0002733_abnormal_thermal_nociception1.84753857
25MP0002735_abnormal_chemical_nociception1.83922161
26MP0001970_abnormal_pain_threshold1.83252643
27MP0002909_abnormal_adrenal_gland1.82850916
28MP0000778_abnormal_nervous_system1.78429330
29MP0002557_abnormal_social/conspecific_i1.72392749
30MP0002067_abnormal_sensory_capabilities1.70997986
31MP0004885_abnormal_endolymph1.67962658
32MP0002184_abnormal_innervation1.64527512
33MP0003879_abnormal_hair_cell1.63440127
34MP0000955_abnormal_spinal_cord1.62143559
35MP0004924_abnormal_behavior1.59988852
36MP0005386_behavior/neurological_phenoty1.59988852
37MP0005646_abnormal_pituitary_gland1.59482767
38MP0003633_abnormal_nervous_system1.44634580
39MP0002882_abnormal_neuron_morphology1.42729970
40MP0002066_abnormal_motor_capabilities/c1.41163135
41MP0003075_altered_response_to1.40235095
42MP0003787_abnormal_imprinting1.37945088
43MP0003283_abnormal_digestive_organ1.31495044
44MP0003123_paternal_imprinting1.29467593
45MP0001984_abnormal_olfaction1.23376420
46MP0003631_nervous_system_phenotype1.19911244
47MP0001346_abnormal_lacrimal_gland1.18132796
48MP0002152_abnormal_brain_morphology1.15597915
49MP0000569_abnormal_digit_pigmentation1.12799417
50MP0001502_abnormal_circadian_rhythm1.12340894
51MP0001177_atelectasis1.10964951
52MP0008961_abnormal_basal_metabolism1.09941275
53MP0005645_abnormal_hypothalamus_physiol1.09339219
54MP0005167_abnormal_blood-brain_barrier1.06878494
55MP0002249_abnormal_larynx_morphology1.06349786
56MP0004142_abnormal_muscle_tone1.05598196
57MP0001905_abnormal_dopamine_level1.05001593
58MP0003690_abnormal_glial_cell1.04593985
59MP0008872_abnormal_physiological_respon1.04463475
60MP0010234_abnormal_vibrissa_follicle1.02108755
61MP0001529_abnormal_vocalization1.01864077
62MP0008874_decreased_physiological_sensi0.97803151
63MP0002069_abnormal_eating/drinking_beha0.96833758
64MP0000751_myopathy0.95690921
65MP0006276_abnormal_autonomic_nervous0.92902608
66MP0000579_abnormal_nail_morphology0.90565424
67MP0001348_abnormal_lacrimal_gland0.90089427
68MP0003634_abnormal_glial_cell0.89541778
69MP0000920_abnormal_myelination0.88356404
70MP0003705_abnormal_hypodermis_morpholog0.88104194
71MP0000566_synostosis0.87050101
72MP0003122_maternal_imprinting0.86154879
73MP0003632_abnormal_nervous_system0.84026991
74MP0002229_neurodegeneration0.83619597
75MP0002638_abnormal_pupillary_reflex0.83467260
76MP0000604_amyloidosis0.82091050
77MP0003938_abnormal_ear_development0.80514600
78MP0004085_abnormal_heartbeat0.78857973
79MP0002090_abnormal_vision0.78474353
80MP0005394_taste/olfaction_phenotype0.76362212
81MP0005499_abnormal_olfactory_system0.76362212
82MP0005535_abnormal_body_temperature0.76132680
83MP0005623_abnormal_meninges_morphology0.74072406
84MP0000026_abnormal_inner_ear0.70017812
85MP0004510_myositis0.69896321
86MP0000631_abnormal_neuroendocrine_gland0.69650182
87MP0000013_abnormal_adipose_tissue0.68603530
88MP0001963_abnormal_hearing_physiology0.67579051
89MP0003137_abnormal_impulse_conducting0.67532794
90MP0004145_abnormal_muscle_electrophysio0.66876143
91MP0000534_abnormal_ureter_morphology0.65989909
92MP0004742_abnormal_vestibular_system0.65467353
93MP0003172_abnormal_lysosome_physiology0.63712858
94MP0004233_abnormal_muscle_weight0.63483826
95MP0005551_abnormal_eye_electrophysiolog0.63038681
96MP0003861_abnormal_nervous_system0.62181832
97MP0002752_abnormal_somatic_nervous0.61915777
98MP0000537_abnormal_urethra_morphology0.61159655
99MP0001485_abnormal_pinna_reflex0.60065936
100MP0002082_postnatal_lethality0.59672573
101MP0010770_preweaning_lethality0.59672573
102MP0001188_hyperpigmentation0.58458375
103MP0005409_darkened_coat_color0.57741462
104MP0002653_abnormal_ependyma_morphology0.57068925
105MP0001299_abnormal_eye_distance/0.56286884
106MP0002081_perinatal_lethality0.55188913
107MP0010769_abnormal_survival0.54893083
108MP0001943_abnormal_respiration0.54028401
109MP0005166_decreased_susceptibility_to0.53115622
110MP0003121_genomic_imprinting0.52708780
111MP0001664_abnormal_digestion0.52446735
112MP0004130_abnormal_muscle_cell0.52064945
113MP0002234_abnormal_pharynx_morphology0.51921646
114MP0010386_abnormal_urinary_bladder0.51572200
115MP0002089_abnormal_postnatal_growth/wei0.51234335
116MP0010768_mortality/aging0.51064224
117MP0004215_abnormal_myocardial_fiber0.50895023
118MP0003183_abnormal_peptide_metabolism0.49488308
119MP0003385_abnormal_body_wall0.49330870
120MP0001958_emphysema0.47547412

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.23559240
2Focal motor seizures (HP:0011153)7.28083072
3Focal seizures (HP:0007359)5.66678494
4Visual hallucinations (HP:0002367)5.23138286
5Action tremor (HP:0002345)4.29280848
6Epileptic encephalopathy (HP:0200134)4.28388692
7Progressive cerebellar ataxia (HP:0002073)4.04171384
8Ankle clonus (HP:0011448)3.93826244
9Febrile seizures (HP:0002373)3.81811505
10Impaired vibration sensation in the lower limbs (HP:0002166)3.80484413
11Atonic seizures (HP:0010819)3.75899444
12Supranuclear gaze palsy (HP:0000605)3.68026293
13Absence seizures (HP:0002121)3.62761424
14Generalized tonic-clonic seizures (HP:0002069)3.62479475
15Poor eye contact (HP:0000817)3.53450714
16Depression (HP:0000716)3.52199972
17Abnormality of the lower motor neuron (HP:0002366)3.44821371
18Papilledema (HP:0001085)3.40246377
19Urinary bladder sphincter dysfunction (HP:0002839)3.36501533
20Dialeptic seizures (HP:0011146)3.31912269
21Broad-based gait (HP:0002136)3.29912709
22Postural instability (HP:0002172)3.26723246
23Dysdiadochokinesis (HP:0002075)3.20654883
24Abnormal social behavior (HP:0012433)3.20001050
25Impaired social interactions (HP:0000735)3.20001050
26Gaze-evoked nystagmus (HP:0000640)3.19230688
27Dysmetria (HP:0001310)3.17189427
28Mutism (HP:0002300)3.16291156
29Torticollis (HP:0000473)3.13382657
30Anxiety (HP:0000739)3.12804608
31Annular pancreas (HP:0001734)3.07419373
32Urinary urgency (HP:0000012)2.99783575
33Megalencephaly (HP:0001355)2.96505150
34Focal dystonia (HP:0004373)2.92452935
35Abnormal eating behavior (HP:0100738)2.85704330
36Genetic anticipation (HP:0003743)2.84416470
37Amblyopia (HP:0000646)2.83451554
38Intention tremor (HP:0002080)2.83153691
39Ventricular fibrillation (HP:0001663)2.79765174
40Tetraplegia (HP:0002445)2.79254200
41Hemiplegia (HP:0002301)2.76704776
42Pointed chin (HP:0000307)2.76164231
43Truncal ataxia (HP:0002078)2.75981671
44Spastic gait (HP:0002064)2.74648244
45Impaired smooth pursuit (HP:0007772)2.72783033
46Stereotypic behavior (HP:0000733)2.70169610
47Insomnia (HP:0100785)2.67483794
48Akinesia (HP:0002304)2.67244684
49Turricephaly (HP:0000262)2.64969953
50Hemiparesis (HP:0001269)2.57996569
51Bradykinesia (HP:0002067)2.57966935
52Craniofacial dystonia (HP:0012179)2.56264363
53Impaired vibratory sensation (HP:0002495)2.55547832
54Neurofibrillary tangles (HP:0002185)2.49642478
55Sleep apnea (HP:0010535)2.43565199
56Scanning speech (HP:0002168)2.43177777
57Cerebral inclusion bodies (HP:0100314)2.43115583
58Ankyloglossia (HP:0010296)2.42958283
59Bundle branch block (HP:0011710)2.39892566
60Abnormality of ocular smooth pursuit (HP:0000617)2.38555830
61Obstructive sleep apnea (HP:0002870)2.38009863
62Cerebral hypomyelination (HP:0006808)2.35476524
63Excessive salivation (HP:0003781)2.34157281
64Drooling (HP:0002307)2.34157281
65Abnormality of binocular vision (HP:0011514)2.31910746
66Diplopia (HP:0000651)2.31910746
67Lower limb muscle weakness (HP:0007340)2.29350088
68Dysmetric saccades (HP:0000641)2.28323085
69Bronchomalacia (HP:0002780)2.27695121
70Delusions (HP:0000746)2.25941740
71Peripheral hypomyelination (HP:0007182)2.25714194
72Progressive inability to walk (HP:0002505)2.18127756
73Hyperventilation (HP:0002883)2.17827732
74Split foot (HP:0001839)2.17055641
75Lower limb amyotrophy (HP:0007210)2.13618893
76Epileptiform EEG discharges (HP:0011182)2.11487962
77Clonus (HP:0002169)2.10647633
78Resting tremor (HP:0002322)2.10362706
79Termporal pattern (HP:0011008)2.09647445
80Insidious onset (HP:0003587)2.09647445
81Status epilepticus (HP:0002133)2.07307858
82EEG with generalized epileptiform discharges (HP:0011198)2.04955070
83Shallow orbits (HP:0000586)2.04311402
84Fetal akinesia sequence (HP:0001989)2.03140466
85Incomplete penetrance (HP:0003829)2.02299234
86Apathy (HP:0000741)2.01949588
87Overriding aorta (HP:0002623)2.01317921
88Hypsarrhythmia (HP:0002521)2.00340002
89Spastic tetraparesis (HP:0001285)1.98122408
90Lower limb asymmetry (HP:0100559)1.97978859
91Abnormal EKG (HP:0003115)1.97238219
92Abnormality of the corticospinal tract (HP:0002492)1.96024105
93Mild short stature (HP:0003502)1.93259463
94Upper limb amyotrophy (HP:0009129)1.92932240
95Distal upper limb amyotrophy (HP:0007149)1.92932240
96Generalized myoclonic seizures (HP:0002123)1.92628426
97Amyotrophic lateral sclerosis (HP:0007354)1.90101104
98Abnormality of the periventricular white matter (HP:0002518)1.88011685
99Aplasia involving bones of the extremities (HP:0009825)1.86605762
100Aplasia involving bones of the upper limbs (HP:0009823)1.86605762
101Aplasia of the phalanges of the hand (HP:0009802)1.86605762
102Rapidly progressive (HP:0003678)1.86330090
103Gait ataxia (HP:0002066)1.85018492
104Neuronal loss in central nervous system (HP:0002529)1.84459507
105Absent speech (HP:0001344)1.83156326
106Hand muscle atrophy (HP:0009130)1.82899380
107Elfin facies (HP:0004428)1.82392855
108Rigidity (HP:0002063)1.82352369
109Bowel diverticulosis (HP:0005222)1.81764882
110Abnormality of saccadic eye movements (HP:0000570)1.81760632
111Hammertoe (HP:0001765)1.81415852
112Hyperacusis (HP:0010780)1.80044400
113Limb dystonia (HP:0002451)1.78671129
114Anosmia (HP:0000458)1.75543615
115Diminished motivation (HP:0000745)1.75279715
116Spinal canal stenosis (HP:0003416)1.73490611
117Polyphagia (HP:0002591)1.73204449
118Intellectual disability, profound (HP:0002187)1.73188593
119Abnormality of oral frenula (HP:0000190)1.73151866
120Agitation (HP:0000713)1.72741230
121Hypoventilation (HP:0002791)1.69311959
122Morphological abnormality of the pyramidal tract (HP:0002062)1.67951101
123Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.64261235

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.18745366
2NTRK34.39137533
3MAP3K94.12937058
4PRKD32.98163099
5DAPK22.90318817
6MARK12.88353826
7MINK12.71357517
8PAK62.52180996
9KSR22.51099560
10MAP3K42.40909364
11NTRK22.30124379
12CAMKK12.21651283
13NTRK12.16729567
14KSR11.94710498
15MAP2K71.78239140
16CDK51.64395019
17DAPK11.63605825
18RIPK41.60410747
19TYRO31.56613648
20STK381.53636500
21PRPF4B1.46399072
22MAP2K41.42881801
23TAOK11.39992121
24TNIK1.39427748
25MAP3K131.37672119
26SIK21.35388015
27ARAF1.33735275
28FES1.33083008
29MAP3K21.28656685
30UHMK11.16285820
31PRKCG1.13186047
32ALK1.09565247
33GRK51.09206716
34CAMK11.09110154
35MAPK131.06592262
36PLK21.06567039
37MAP3K121.05868019
38CDK191.02548509
39PRKCH0.99685345
40STK110.98915244
41CDK180.97246610
42CDK150.96815440
43LATS20.95434608
44RAF10.94476821
45PHKG10.91891983
46PHKG20.91891983
47CDK140.88606155
48LMTK20.87992475
49CDK11A0.84845653
50SGK2230.82837482
51SGK4940.82837482
52RIPK10.82302601
53PINK10.82231261
54CAMK2A0.81886809
55MARK20.80116137
56RET0.80074451
57PTK2B0.78923746
58PDK10.76657075
59MAPK120.75057294
60PKN10.74002625
61PAK30.73401387
62LIMK10.73314360
63CAMKK20.73202406
64TESK10.72600567
65SGK30.71182925
66NEK10.70057626
67MAP3K70.69107280
68PDPK10.68204263
69FGFR20.68090672
70SGK10.67236345
71CAMK2B0.67083800
72BRSK10.66291840
73PNCK0.66130975
74SGK20.63682144
75ROCK20.63243969
76MAP3K10.61216248
77CAMK40.58106676
78DYRK1A0.57267864
79BRAF0.55736124
80DMPK0.54126075
81NEK60.54108483
82RPS6KA30.53880835
83CDC42BPA0.53146383
84PRKCZ0.52980817
85TNK20.52701299
86DDR20.52548390
87CSNK1G20.50826289
88FYN0.49464534
89DAPK30.48904299
90ROCK10.47253144
91MAPK100.46509147
92TRIB30.45792777
93EPHB20.45161417
94BMPR20.44997740
95CAMK2D0.44226448
96PTK20.44069394
97CASK0.43926040
98CAMK1G0.42424997
99DYRK20.41567758
100SCYL20.40919657
101MAP2K10.39612566
102ICK0.39504340
103CAMK1D0.38191478
104OXSR10.37315244
105PDGFRA0.37003026
106PRKD20.36162233
107BMX0.35444758
108MAP3K110.33391849
109EEF2K0.32295571
110CCNB10.32152216
111FER0.32051035
112MAPK80.31996217
113CAMK2G0.31197069
114MOS0.31083848
115PAK20.30838847
116ERBB20.30441230
117PRKCB0.29941255
118RPS6KA20.29754863
119PRKCE0.29046336
120SRC0.27459532
121GSK3B0.26802635

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.22373510
2Synaptic vesicle cycle_Homo sapiens_hsa047213.07327768
3Olfactory transduction_Homo sapiens_hsa047403.01729116
4Circadian entrainment_Homo sapiens_hsa047132.75056721
5Long-term potentiation_Homo sapiens_hsa047202.66231690
6Glutamatergic synapse_Homo sapiens_hsa047242.58326286
7GABAergic synapse_Homo sapiens_hsa047272.56938798
8Amphetamine addiction_Homo sapiens_hsa050312.46674976
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.41130544
10Morphine addiction_Homo sapiens_hsa050322.39559787
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.27338587
12Salivary secretion_Homo sapiens_hsa049702.18024251
13Dopaminergic synapse_Homo sapiens_hsa047282.10727252
14Cholinergic synapse_Homo sapiens_hsa047252.00861950
15Insulin secretion_Homo sapiens_hsa049112.00377872
16Gastric acid secretion_Homo sapiens_hsa049712.00222335
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.99162952
18Nitrogen metabolism_Homo sapiens_hsa009101.89692509
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77276618
20Oxytocin signaling pathway_Homo sapiens_hsa049211.72727299
21Cocaine addiction_Homo sapiens_hsa050301.68585638
22Vitamin B6 metabolism_Homo sapiens_hsa007501.68291790
23Calcium signaling pathway_Homo sapiens_hsa040201.58899107
24GnRH signaling pathway_Homo sapiens_hsa049121.55523638
25Renin secretion_Homo sapiens_hsa049241.55151396
26Long-term depression_Homo sapiens_hsa047301.54011082
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.52027674
28Glioma_Homo sapiens_hsa052141.40707172
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39031223
30Gap junction_Homo sapiens_hsa045401.38597178
31Taste transduction_Homo sapiens_hsa047421.37735333
32Serotonergic synapse_Homo sapiens_hsa047261.36459733
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32715220
34cAMP signaling pathway_Homo sapiens_hsa040241.31902605
35Type II diabetes mellitus_Homo sapiens_hsa049301.26709938
36Estrogen signaling pathway_Homo sapiens_hsa049151.22394819
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16686928
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14398978
39ErbB signaling pathway_Homo sapiens_hsa040121.13879464
40Axon guidance_Homo sapiens_hsa043601.13219278
41Melanogenesis_Homo sapiens_hsa049161.12808587
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06687546
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04914757
44Phospholipase D signaling pathway_Homo sapiens_hsa040721.00757137
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96957373
46Oocyte meiosis_Homo sapiens_hsa041140.95404823
47Dorso-ventral axis formation_Homo sapiens_hsa043200.94213647
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.92408537
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81970699
50Pancreatic secretion_Homo sapiens_hsa049720.81788472
51Collecting duct acid secretion_Homo sapiens_hsa049660.80680114
52Thyroid hormone synthesis_Homo sapiens_hsa049180.79457834
53Neurotrophin signaling pathway_Homo sapiens_hsa047220.79373064
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79269576
55Choline metabolism in cancer_Homo sapiens_hsa052310.78711463
56VEGF signaling pathway_Homo sapiens_hsa043700.77507220
57Dilated cardiomyopathy_Homo sapiens_hsa054140.76616493
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75363077
59Cardiac muscle contraction_Homo sapiens_hsa042600.71920091
60MAPK signaling pathway_Homo sapiens_hsa040100.71891867
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71535140
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69630507
63mTOR signaling pathway_Homo sapiens_hsa041500.67682047
64Rap1 signaling pathway_Homo sapiens_hsa040150.67344143
65Hippo signaling pathway_Homo sapiens_hsa043900.67080848
66Non-small cell lung cancer_Homo sapiens_hsa052230.66907886
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65056127
68Endocytosis_Homo sapiens_hsa041440.61706846
69Bile secretion_Homo sapiens_hsa049760.59913595
70Ras signaling pathway_Homo sapiens_hsa040140.59673163
71Endometrial cancer_Homo sapiens_hsa052130.59433627
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.58744846
73Glucagon signaling pathway_Homo sapiens_hsa049220.57676941
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57007297
75Alcoholism_Homo sapiens_hsa050340.54422625
76Vibrio cholerae infection_Homo sapiens_hsa051100.52949274
77Tight junction_Homo sapiens_hsa045300.52137798
78Phototransduction_Homo sapiens_hsa047440.52030049
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51252007
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50822930
81Prion diseases_Homo sapiens_hsa050200.50320752
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49117133
83Type I diabetes mellitus_Homo sapiens_hsa049400.47632252
84Wnt signaling pathway_Homo sapiens_hsa043100.46962474
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46506423
86Renal cell carcinoma_Homo sapiens_hsa052110.46304296
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45941461
88AMPK signaling pathway_Homo sapiens_hsa041520.45440668
89Inositol phosphate metabolism_Homo sapiens_hsa005620.45215822
90Chemokine signaling pathway_Homo sapiens_hsa040620.44626793
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44130194
92Insulin signaling pathway_Homo sapiens_hsa049100.44029776
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43552891
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42979386
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41781870
96Focal adhesion_Homo sapiens_hsa045100.38525258
97Hedgehog signaling pathway_Homo sapiens_hsa043400.35879723
98Circadian rhythm_Homo sapiens_hsa047100.33691949
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33587508
100Ovarian steroidogenesis_Homo sapiens_hsa049130.33278722
101Protein digestion and absorption_Homo sapiens_hsa049740.32935081
102African trypanosomiasis_Homo sapiens_hsa051430.32882667
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32167247
104Colorectal cancer_Homo sapiens_hsa052100.31961001
105Arginine and proline metabolism_Homo sapiens_hsa003300.31210455
106Basal cell carcinoma_Homo sapiens_hsa052170.30841287
1072-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30418402
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.30404205
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30225181
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29288123
111Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29171895
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29034003

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