ADGRE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.81785291
2modulation by symbiont of host defense response (GO:0052031)5.51314808
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.51314808
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.51314808
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.51314808
6modulation by symbiont of host immune response (GO:0052553)5.51314808
7positive regulation by symbiont of host defense response (GO:0052509)5.51314808
8negative regulation of interleukin-12 production (GO:0032695)5.29747766
9response to peptidoglycan (GO:0032494)5.29386736
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.17271920
11negative regulation of cell killing (GO:0031342)5.17271920
12macrophage activation involved in immune response (GO:0002281)5.01539134
13neutrophil activation involved in immune response (GO:0002283)4.99635189
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.53628735
15detection of molecule of bacterial origin (GO:0032490)4.50402126
16cellular extravasation (GO:0045123)4.43227233
17regulation of B cell receptor signaling pathway (GO:0050855)4.27246941
18positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.24910598
19regulation of gamma-delta T cell activation (GO:0046643)4.23013695
20detection of other organism (GO:0098543)4.22987697
21regulation of interferon-beta biosynthetic process (GO:0045357)4.14652025
22microglial cell activation (GO:0001774)4.10299391
23immunoglobulin mediated immune response (GO:0016064)4.06705857
24neutrophil activation (GO:0042119)3.99739604
25detection of external biotic stimulus (GO:0098581)3.92138822
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.92024490
27antigen processing and presentation of endogenous antigen (GO:0019883)3.88128506
28macrophage activation (GO:0042116)3.87498525
29granulocyte activation (GO:0036230)3.86278940
30antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.85250514
31detection of bacterium (GO:0016045)3.83317042
32response to host immune response (GO:0052572)3.81710570
33response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.81710570
34leukocyte aggregation (GO:0070486)3.76305544
35lipopolysaccharide-mediated signaling pathway (GO:0031663)3.71883355
36myeloid cell activation involved in immune response (GO:0002275)3.70386133
37germinal center formation (GO:0002467)3.62330301
38neutrophil mediated immunity (GO:0002446)3.60111866
39negative regulation of lymphocyte mediated immunity (GO:0002707)3.55454255
40negative regulation of T cell mediated immunity (GO:0002710)3.55349497
41detection of biotic stimulus (GO:0009595)3.53835299
42response to muramyl dipeptide (GO:0032495)3.52216606
43regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.51911247
44respiratory burst (GO:0045730)3.48917428
45antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.47087399
46defense response to protozoan (GO:0042832)3.45708550
47regulation of mast cell degranulation (GO:0043304)3.45426535
48regulation of gamma-delta T cell differentiation (GO:0045586)3.43043355
49regulation of interferon-alpha production (GO:0032647)3.42991319
50response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.42280180
51response to host (GO:0075136)3.42280180
52response to host defenses (GO:0052200)3.42280180
53cellular response to type I interferon (GO:0071357)3.39592620
54type I interferon signaling pathway (GO:0060337)3.39592620
55response to type I interferon (GO:0034340)3.38650898
56positive regulation of mast cell activation (GO:0033005)3.38383345
57regulation of mast cell activation (GO:0033003)3.33220362
58positive regulation of interferon-alpha production (GO:0032727)3.29010837
59response to protozoan (GO:0001562)3.27629625
60positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.26561711
61interferon-gamma-mediated signaling pathway (GO:0060333)3.26550970
62regulation of mast cell activation involved in immune response (GO:0033006)3.25486950
63T-helper 1 type immune response (GO:0042088)3.24577964
64negative regulation of cytokine production involved in immune response (GO:0002719)3.19939772
65positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.19356973
66negative regulation of leukocyte mediated immunity (GO:0002704)3.18655769
67B cell mediated immunity (GO:0019724)3.12461965
68response to interleukin-15 (GO:0070672)3.11683143
69regulation of dendritic cell antigen processing and presentation (GO:0002604)3.08477511
70regulation of myeloid leukocyte mediated immunity (GO:0002886)3.08089274
71myeloid leukocyte mediated immunity (GO:0002444)3.03245271
72positive regulation of B cell differentiation (GO:0045579)3.02900668
73production of molecular mediator involved in inflammatory response (GO:0002532)3.01425679
74regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.99912400
75positive regulation of mast cell activation involved in immune response (GO:0033008)2.99197465
76positive regulation of mast cell degranulation (GO:0043306)2.99197465
77regulation of leukocyte degranulation (GO:0043300)2.98500008
78negative regulation of interleukin-6 production (GO:0032715)2.98302454
79positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.97589912
80negative regulation of erythrocyte differentiation (GO:0045647)2.96158182
81regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.94978924
82leukocyte degranulation (GO:0043299)2.94148562
83negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.94052841
84positive regulation of toll-like receptor signaling pathway (GO:0034123)2.93452111
85regulation of antigen processing and presentation (GO:0002577)2.93359298
86myeloid leukocyte activation (GO:0002274)2.92534702
87leukocyte migration involved in inflammatory response (GO:0002523)2.92425953
88positive regulation of interferon-beta production (GO:0032728)2.90805582
89neutrophil chemotaxis (GO:0030593)2.89979379
90regulation of tolerance induction (GO:0002643)2.89157432
91B cell receptor signaling pathway (GO:0050853)2.88674863
92regulation of T-helper 2 cell differentiation (GO:0045628)2.87324401
93positive regulation of antigen processing and presentation (GO:0002579)2.87261105
94neutrophil migration (GO:1990266)2.82425082
95regulation of interleukin-12 production (GO:0032655)2.81772731
96T cell migration (GO:0072678)2.81719010
97regulation of interleukin-8 biosynthetic process (GO:0045414)2.80605229
98regulation of B cell differentiation (GO:0045577)2.79863599
99cellular response to interleukin-15 (GO:0071350)2.78857329
100negative regulation of innate immune response (GO:0045824)2.78254175

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.15445210
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.21551554
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.84642754
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.98685939
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.67556754
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.62224699
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.51102983
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.41075502
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.25160618
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.08699199
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.94512878
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.88943099
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.79715372
14RUNX_20019798_ChIP-Seq_JUKART_Human2.62879295
15SPI1_23127762_ChIP-Seq_K562_Human2.57297357
16SPI1_23547873_ChIP-Seq_NB4_Human2.55929701
17SCL_19346495_ChIP-Seq_HPC-7_Human2.53967662
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.50614641
19VDR_24763502_ChIP-Seq_THP-1_Human2.43492125
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.37836359
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.35622240
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.33920942
23VDR_24787735_ChIP-Seq_THP-1_Human2.27132305
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.25294468
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.20636290
26MYB_26560356_Chip-Seq_TH2_Human2.19212757
27EGR1_19374776_ChIP-ChIP_THP-1_Human2.11500509
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.08859605
29VDR_21846776_ChIP-Seq_THP-1_Human2.06906427
30BRD4_27068464_Chip-Seq_AML-cells_Mouse2.04584884
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.98743724
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.98567540
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.97954189
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.87240105
35MAF_26560356_Chip-Seq_TH1_Human1.86463324
36GATA1_22025678_ChIP-Seq_K562_Human1.78617393
37MYB_26560356_Chip-Seq_TH1_Human1.76907623
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.74401692
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.73901336
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.69085714
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.64568951
42GATA3_27048872_Chip-Seq_THYMUS_Human1.64560815
43UTX_26944678_Chip-Seq_JUKART_Human1.61472602
44PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.60546604
45PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.60420489
46GATA3_26560356_Chip-Seq_TH2_Human1.52042483
47CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51852191
48GATA1_19941827_ChIP-Seq_MEL_Mouse1.48092100
49PU_27001747_Chip-Seq_BMDM_Mouse1.45800275
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41850171
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36777885
52TCF7_22412390_ChIP-Seq_EML_Mouse1.34730307
53GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.33972610
54SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33507682
55MYC_22102868_ChIP-Seq_BL_Human1.32184710
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29417184
57GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29405379
58NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.26256983
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25633038
60MAF_26560356_Chip-Seq_TH2_Human1.25632348
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25628007
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.24336491
63VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.23967318
64GATA1_19941826_ChIP-Seq_K562_Human1.21323411
65CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20981327
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20671372
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20164437
68CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19461655
69CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17695079
70PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15919648
71KDM2B_26808549_Chip-Seq_DND41_Human1.13164165
72STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12805222
73STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12180372
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10575392
75SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08322339
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04897491
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02487877
78KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02306715
79GATA2_19941826_ChIP-Seq_K562_Human1.00338032
80IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92762290
81GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92059413
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87696974
83SMRT_27268052_Chip-Seq_Bcells_Human0.87036309
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86722770
85GATA1_19941827_ChIP-Seq_MEL86_Mouse0.82958728
86BCL6_27268052_Chip-Seq_Bcells_Human0.81498184
87NOTCH1_21737748_ChIP-Seq_TLL_Human0.78957863
88PU.1_20513432_ChIP-Seq_Bcells_Mouse0.78775520
89STAT1_20625510_ChIP-Seq_HELA_Human0.78183262
90RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.74741327
91BCOR_27268052_Chip-Seq_Bcells_Human0.72911359
92RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70803103
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70131624
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.69977409
95ELK3_25401928_ChIP-Seq_HUVEC_Human0.69936560
96SPI1_20517297_ChIP-Seq_HL60_Human0.68011610
97KDM2B_26808549_Chip-Seq_JURKAT_Human0.67379296
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.66382072
99EGR1_19032775_ChIP-ChIP_M12_Human0.65345493
100NCOR1_26117541_ChIP-Seq_K562_Human0.65082346

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.82670340
2MP0003303_peritoneal_inflammation4.59228614
3MP0003436_decreased_susceptibility_to3.97112856
4MP0001835_abnormal_antigen_presentation3.67073281
5MP0002419_abnormal_innate_immunity3.09336573
6MP0009785_altered_susceptibility_to3.06410961
7MP0006082_CNS_inflammation2.94693144
8MP0002148_abnormal_hypersensitivity_rea2.87011617
9MP0005671_abnormal_response_to2.84968126
10MP0005000_abnormal_immune_tolerance2.83502329
11MP0005025_abnormal_response_to2.78685001
12MP0001790_abnormal_immune_system2.74979120
13MP0005387_immune_system_phenotype2.74979120
14MP0001800_abnormal_humoral_immune2.70688209
15MP0002723_abnormal_immune_serum2.52028416
16MP0002452_abnormal_antigen_presenting2.48572450
17MP0000685_abnormal_immune_system2.46438702
18MP0003300_gastrointestinal_ulcer2.36364312
19MP0009278_abnormal_bone_marrow2.31766995
20MP0002420_abnormal_adaptive_immunity2.30601826
21MP0001819_abnormal_immune_cell2.29177165
22MP0009764_decreased_sensitivity_to2.19166403
23MP0001533_abnormal_skeleton_physiology2.17885488
24MP0003172_abnormal_lysosome_physiology2.11475924
25MP0005464_abnormal_platelet_physiology1.93824595
26MP0003191_abnormal_cellular_cholesterol1.93686187
27MP0002405_respiratory_system_inflammati1.89370500
28MP0001845_abnormal_inflammatory_respons1.81733131
29MP0005451_abnormal_body_composition1.77857849
30MP0004947_skin_inflammation1.75836947
31MP0010155_abnormal_intestine_physiology1.74354724
32MP0005397_hematopoietic_system_phenotyp1.74252275
33MP0001545_abnormal_hematopoietic_system1.74252275
34MP0004510_myositis1.72607300
35MP0000716_abnormal_immune_system1.70279029
36MP0005058_abnormal_lysosome_morphology1.69794224
37MP0002398_abnormal_bone_marrow1.62408410
38MP0003075_altered_response_to1.61723120
39MP0008469_abnormal_protein_level1.56042351
40MP0008260_abnormal_autophagy1.55058608
41MP0003828_pulmonary_edema1.53432023
42MP0003763_abnormal_thymus_physiology1.52307083
43MP0005310_abnormal_salivary_gland1.50050607
44MP0000689_abnormal_spleen_morphology1.38609432
45MP0002998_abnormal_bone_remodeling1.34642043
46MP0009333_abnormal_splenocyte_physiolog1.33649148
47MP0000343_altered_response_to1.33278227
48MP0002722_abnormal_immune_system1.33276574
49MP0002429_abnormal_blood_cell1.31439834
50MP0008004_abnormal_stomach_pH1.31357595
51MP0001853_heart_inflammation1.31307580
52MP0003183_abnormal_peptide_metabolism1.29128334
53MP0005167_abnormal_blood-brain_barrier1.29127424
54MP0004883_abnormal_blood_vessel1.27229902
55MP0000465_gastrointestinal_hemorrhage1.26186549
56MP0003690_abnormal_glial_cell1.25684227
57MP0003656_abnormal_erythrocyte_physiolo1.22213774
58MP0000569_abnormal_digit_pigmentation1.21759131
59MP0000604_amyloidosis1.20320952
60MP0000858_altered_metastatic_potential1.19628928
61MP0005164_abnormal_response_to1.17625892
62MP0002277_abnormal_respiratory_mucosa1.15135443
63MP0005166_decreased_susceptibility_to1.13477486
64MP0002332_abnormal_exercise_endurance1.12128153
65MP0002132_abnormal_respiratory_system1.11594022
66MP0003448_altered_tumor_morphology1.09241645
67MP0003866_abnormal_defecation1.08935792
68MP0009840_abnormal_foam_cell1.07156228
69MP0003195_calcinosis1.06091277
70MP0000703_abnormal_thymus_morphology0.98180218
71MP0001851_eye_inflammation0.95986740
72MP0006054_spinal_hemorrhage0.95087551
73MP0004381_abnormal_hair_follicle0.94998754
74MP0002396_abnormal_hematopoietic_system0.93739152
75MP0009763_increased_sensitivity_to0.91876087
76MP0004808_abnormal_hematopoietic_stem0.90179772
77MP0003806_abnormal_nucleotide_metabolis0.88616204
78MP0009765_abnormal_xenobiotic_induced0.85655561
79MP0001663_abnormal_digestive_system0.84812577
80MP0005390_skeleton_phenotype0.84454454
81MP0002138_abnormal_hepatobiliary_system0.80236764
82MP0003045_fibrosis0.77119295
83MP0003646_muscle_fatigue0.76756903
84MP0000015_abnormal_ear_pigmentation0.74106663
85MP0002254_reproductive_system_inflammat0.72662323
86MP0000249_abnormal_blood_vessel0.66612347
87MP0008874_decreased_physiological_sensi0.64783583
88MP0003453_abnormal_keratinocyte_physiol0.63001413
89MP0002933_joint_inflammation0.61927128
90MP0000371_diluted_coat_color0.60426909
91MP0003795_abnormal_bone_structure0.59850167
92MP0002166_altered_tumor_susceptibility0.58875771
93MP0003221_abnormal_cardiomyocyte_apopto0.57456849
94MP0005535_abnormal_body_temperature0.56887710
95MP0000920_abnormal_myelination0.56861315
96MP0005075_abnormal_melanosome_morpholog0.55245033
97MP0001873_stomach_inflammation0.54795946
98MP0004130_abnormal_muscle_cell0.54115058
99MP0005319_abnormal_enzyme/_coenzyme0.53417472
100MP0002693_abnormal_pancreas_physiology0.53277376

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)5.92625576
2Myositis (HP:0100614)5.84927275
3Orchitis (HP:0100796)5.81594177
4Recurrent abscess formation (HP:0002722)5.77728435
5Eczematoid dermatitis (HP:0000976)5.77146896
6Optic neuritis (HP:0100653)5.75839560
7Retrobulbar optic neuritis (HP:0100654)5.75839560
8Abnormality of macrophages (HP:0004311)5.31771393
9Stomatitis (HP:0010280)5.31668909
10Elevated erythrocyte sedimentation rate (HP:0003565)4.64802917
11Recurrent gram-negative bacterial infections (HP:0005420)4.62968456
12Mediastinal lymphadenopathy (HP:0100721)4.11439102
13Recurrent fungal infections (HP:0002841)4.09955709
14Keratoconjunctivitis sicca (HP:0001097)4.09724586
15Abnormality of liposaccharide metabolism (HP:0010968)3.89777124
16Abnormality of glycosphingolipid metabolism (HP:0004343)3.89777124
17Abnormality of glycolipid metabolism (HP:0010969)3.89777124
18Keratoconjunctivitis (HP:0001096)3.84534483
19Recurrent skin infections (HP:0001581)3.82127308
20Obstructive lung disease (HP:0006536)3.61039893
21Chronic obstructive pulmonary disease (HP:0006510)3.61039893
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.58283510
23Encephalitis (HP:0002383)3.58133755
24Gastrointestinal infarctions (HP:0005244)3.56911241
25Meningitis (HP:0001287)3.52829454
26Vasculitis (HP:0002633)3.46977957
27Chronic mucocutaneous candidiasis (HP:0002728)3.41819608
28Recurrent cutaneous fungal infections (HP:0011370)3.41819608
29Increased cerebral lipofuscin (HP:0011813)3.41423905
30Hemoptysis (HP:0002105)3.21965858
31T lymphocytopenia (HP:0005403)3.21803221
32Spontaneous hematomas (HP:0007420)3.20624650
33Gingivitis (HP:0000230)3.19047245
34Pulmonary infiltrates (HP:0002113)3.15302745
35Abnormality of T cell number (HP:0011839)3.14194739
36Urticaria (HP:0001025)3.09943486
37Leukocytosis (HP:0001974)3.06259712
38Arterial thrombosis (HP:0004420)3.03755437
39Autoimmune thrombocytopenia (HP:0001973)2.99200077
40Increased neuronal autofluorescent lipopigment (HP:0002074)2.94189299
41Recurrent viral infections (HP:0004429)2.93449457
42Increased IgE level (HP:0003212)2.92746118
43Episodic fever (HP:0001954)2.90095727
44Prolonged bleeding time (HP:0003010)2.86836176
45Chest pain (HP:0100749)2.79629314
46Amyloidosis (HP:0011034)2.78955447
47Gangrene (HP:0100758)2.75199052
48Gingival bleeding (HP:0000225)2.70532176
49Loss of speech (HP:0002371)2.69601747
50Anorexia (HP:0002039)2.69536649
51Pulmonary embolism (HP:0002204)2.63715412
52Increased IgM level (HP:0003496)2.61658683
53Vacuolated lymphocytes (HP:0001922)2.60536182
54Epistaxis (HP:0000421)2.53044921
55Abnormality of T cells (HP:0002843)2.51310826
56Dysostosis multiplex (HP:0000943)2.51278104
57Petechiae (HP:0000967)2.47661073
58Cellulitis (HP:0100658)2.46710270
59Disinhibition (HP:0000734)2.42310921
60Abnormality of the pleura (HP:0002103)2.41724772
61Granulocytopenia (HP:0001913)2.37419316
62Peritonitis (HP:0002586)2.36961568
63Increased serum ferritin (HP:0003281)2.36702207
64Pustule (HP:0200039)2.35779747
65Inflammation of the large intestine (HP:0002037)2.35090505
66Hematochezia (HP:0002573)2.34524189
67Vertigo (HP:0002321)2.31407792
68Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.30135947
69Polyneuropathy (HP:0001271)2.27405843
70Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.26868076
71Systemic lupus erythematosus (HP:0002725)2.25180474
72Panhypogammaglobulinemia (HP:0003139)2.25171639
73Eosinophilia (HP:0001880)2.24845100
74Autoimmune hemolytic anemia (HP:0001890)2.24024495
75Keratitis (HP:0000491)2.18915199
76Gastrointestinal inflammation (HP:0004386)2.18663073
77Abnormality of the endocardium (HP:0004306)2.17162542
78Osteomyelitis (HP:0002754)2.15617445
79Abnormality of iron homeostasis (HP:0011031)2.15398228
80Hypergammaglobulinemia (HP:0010702)2.15389245
81Hypochromic anemia (HP:0001931)2.10847320
82Purpura (HP:0000979)2.06236756
83Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04594512
84Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04594512
85Abnormality of polysaccharide metabolism (HP:0011012)2.04594512
86Acne (HP:0001061)2.04206383
87Abnormality of T cell physiology (HP:0011840)2.03251088
88Colitis (HP:0002583)2.03192313
89Sepsis (HP:0100806)2.03052747
90Glomerulopathy (HP:0100820)1.98994177
91Hypochromic microcytic anemia (HP:0004840)1.97622835
92Abnormality of the pericardium (HP:0001697)1.94783086
93Abnormality of eosinophils (HP:0001879)1.90486513
94Mutism (HP:0002300)1.89448387
95Abnormality of the peritoneum (HP:0002585)1.88433213
96Abnormality of transition element cation homeostasis (HP:0011030)1.88164946
97Chronic otitis media (HP:0000389)1.86794755
98Amaurosis fugax (HP:0100576)1.85078295
99Hepatosplenomegaly (HP:0001433)1.84907359
100Mucopolysacchariduria (HP:0008155)1.83829996

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.61485029
2BLK3.43176411
3MAP4K13.26361204
4IRAK43.09639736
5TYK22.75049853
6CSK2.71055560
7MAP3K142.63422911
8MAP2K32.61028787
9TXK2.29470039
10FES2.18790222
11IRAK32.04906563
12FGR2.04485347
13IKBKE2.01705563
14JAK31.99981069
15MATK1.97164003
16ERN11.95273897
17TAOK31.94404101
18ZAP701.92688812
19TBK11.82139245
20SYK1.75958695
21PRPF4B1.75670479
22TAOK11.71737763
23MAP3K31.70734273
24TNK21.63823665
25MAP3K111.61400324
26BMPR21.60514800
27IKBKB1.59069982
28BTK1.58387461
29IRAK11.52853297
30GRK71.51979979
31HCK1.51124620
32GRK61.49161596
33KIT1.46741438
34LYN1.45928114
35EPHB11.41031069
36JAK21.38781936
37JAK11.36570503
38MAP3K131.33012661
39CSF1R1.30727068
40MAP3K11.27034367
41TAOK21.23494461
42LCK1.15813352
43TGFBR21.11152488
44MARK31.09171682
45FRK1.07673701
46IRAK21.06965855
47TEC0.98171514
48ACVR1B0.96794099
49SIK30.94417140
50ITK0.93328944
51CDC42BPA0.93013415
52YES10.87906468
53ADRBK20.84556036
54STK100.84178943
55PIK3CG0.84049627
56DAPK20.78504000
57KSR20.76599981
58PDK10.76119673
59MAP3K50.76071550
60CHUK0.74020063
61MARK20.72415116
62PIM10.66425019
63EPHA30.65712911
64MAP3K60.64447142
65MAP2K60.61801031
66SIK20.60727897
67PDPK10.59263720
68CAMKK20.57878763
69MAP3K20.54207394
70MOS0.54206414
71PTK2B0.52901914
72HIPK20.52173460
73FYN0.49978245
74PRKCQ0.49526407
75MAPK70.48520547
76DYRK30.48304977
77PRKD20.47727582
78FGFR30.44308074
79RPS6KA60.41760455
80SGK30.40816931
81RPS6KL10.40807988
82RPS6KC10.40807988
83MAPK120.40779552
84STK110.40767735
85PTK60.38673017
86NLK0.38210078
87CAMK1D0.36570624
88SGK20.36258383
89MAP3K70.35198393
90MAP2K40.34931690
91ABL10.33515510
92PRKAA20.31192675
93LRRK20.30495175
94DYRK1B0.30009102
95MAPKAPK20.29161830
96WNK10.28839232
97TESK20.28526325
98RAF10.28149256
99DDR20.25708119
100KSR10.25267890

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.10009998
2Osteoclast differentiation_Homo sapiens_hsa043802.99877953
3Staphylococcus aureus infection_Homo sapiens_hsa051502.94401649
4Allograft rejection_Homo sapiens_hsa053302.46364458
5Graft-versus-host disease_Homo sapiens_hsa053322.45609875
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.45118797
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.42278311
8Tuberculosis_Homo sapiens_hsa051522.31180434
9Malaria_Homo sapiens_hsa051442.17119578
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.16323370
11Autoimmune thyroid disease_Homo sapiens_hsa053202.12118244
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.10843119
13Legionellosis_Homo sapiens_hsa051342.00108837
14B cell receptor signaling pathway_Homo sapiens_hsa046621.95967369
15Asthma_Homo sapiens_hsa053101.90150098
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.85234042
17Type I diabetes mellitus_Homo sapiens_hsa049401.83829455
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.82499008
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.80313745
20Rheumatoid arthritis_Homo sapiens_hsa053231.79981626
21TNF signaling pathway_Homo sapiens_hsa046681.75537787
22Hematopoietic cell lineage_Homo sapiens_hsa046401.73825142
23Primary immunodeficiency_Homo sapiens_hsa053401.68106414
24Measles_Homo sapiens_hsa051621.66623257
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.65580413
26Influenza A_Homo sapiens_hsa051641.63682268
27Other glycan degradation_Homo sapiens_hsa005111.61903077
28Toxoplasmosis_Homo sapiens_hsa051451.59491910
29Chemokine signaling pathway_Homo sapiens_hsa040621.55123917
30African trypanosomiasis_Homo sapiens_hsa051431.53621113
31Antigen processing and presentation_Homo sapiens_hsa046121.53522199
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.53228891
33Pertussis_Homo sapiens_hsa051331.52761045
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48373204
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.43029637
36Lysosome_Homo sapiens_hsa041421.41334015
37Acute myeloid leukemia_Homo sapiens_hsa052211.38584859
38T cell receptor signaling pathway_Homo sapiens_hsa046601.35746644
39Phagosome_Homo sapiens_hsa041451.34460743
40Herpes simplex infection_Homo sapiens_hsa051681.30702231
41Viral myocarditis_Homo sapiens_hsa054161.26669726
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.24671925
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22416170
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18032461
45Salmonella infection_Homo sapiens_hsa051321.16849466
46Hepatitis B_Homo sapiens_hsa051611.12800629
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.09921228
48Hepatitis C_Homo sapiens_hsa051601.09319301
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05035240
50Platelet activation_Homo sapiens_hsa046110.98796529
51Glycosaminoglycan degradation_Homo sapiens_hsa005310.93800418
52Shigellosis_Homo sapiens_hsa051310.88711629
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87407274
54Apoptosis_Homo sapiens_hsa042100.85872305
55Dorso-ventral axis formation_Homo sapiens_hsa043200.84485536
56Prolactin signaling pathway_Homo sapiens_hsa049170.83620146
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.82180142
58VEGF signaling pathway_Homo sapiens_hsa043700.75818536
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72166236
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.72044865
61Amoebiasis_Homo sapiens_hsa051460.70785174
62Non-small cell lung cancer_Homo sapiens_hsa052230.68843387
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68219809
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66553044
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.66482257
66Pancreatic cancer_Homo sapiens_hsa052120.65477781
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.62125624
68Epstein-Barr virus infection_Homo sapiens_hsa051690.61831146
69Chronic myeloid leukemia_Homo sapiens_hsa052200.60084768
70Type II diabetes mellitus_Homo sapiens_hsa049300.59371484
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54148056
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53911606
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53347434
74FoxO signaling pathway_Homo sapiens_hsa040680.53009002
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51364987
76Renal cell carcinoma_Homo sapiens_hsa052110.49837607
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.48798114
78Notch signaling pathway_Homo sapiens_hsa043300.45909437
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43278399
80Viral carcinogenesis_Homo sapiens_hsa052030.43261165
81HIF-1 signaling pathway_Homo sapiens_hsa040660.43041827
82Collecting duct acid secretion_Homo sapiens_hsa049660.42949497
83Insulin resistance_Homo sapiens_hsa049310.42156174
84Endocytosis_Homo sapiens_hsa041440.40874594
85GnRH signaling pathway_Homo sapiens_hsa049120.39376437
86MAPK signaling pathway_Homo sapiens_hsa040100.38641354
87Complement and coagulation cascades_Homo sapiens_hsa046100.38052432
88HTLV-I infection_Homo sapiens_hsa051660.37166382
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35338535
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35165257
91mTOR signaling pathway_Homo sapiens_hsa041500.34518878
92Bladder cancer_Homo sapiens_hsa052190.34397974
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30610353
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29834238
95Choline metabolism in cancer_Homo sapiens_hsa052310.29700405
96Regulation of autophagy_Homo sapiens_hsa041400.29032158
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.25638194
98Sphingolipid metabolism_Homo sapiens_hsa006000.21685530
99Endometrial cancer_Homo sapiens_hsa052130.20035076
100ErbB signaling pathway_Homo sapiens_hsa040120.19901332

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