ADGRE4P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the EGF-TM7 receptor gene family which is thought to play a role in leukocyte adhesion and migration. In other vertebrates, including nonhuman primates, this gene encodes a protein containing N-terminal EGF domains and a C-terminal transmembrane domain. Sequence evidence for the human gene, however, indicates nucleotide deletion in the genomic sequence would result in frameshift and early termination of translation. A protein expressed by this gene would be soluble rather than expressed on the cell surface. As the encoded protein has not been detected, this gene may represent a transcribed pseudogene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.45185465
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.82379081
3negative regulation of cell killing (GO:0031342)5.82379081
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.29196072
5regulation of B cell receptor signaling pathway (GO:0050855)5.24013674
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.23322047
7positive regulation by organism of defense response of other organism involved in symbiotic interact5.23322047
8modulation by symbiont of host immune response (GO:0052553)5.23322047
9positive regulation by symbiont of host defense response (GO:0052509)5.23322047
10modulation by symbiont of host defense response (GO:0052031)5.23322047
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.23322047
12neutrophil activation involved in immune response (GO:0002283)5.09653092
13cellular extravasation (GO:0045123)4.81850803
14regulation of gamma-delta T cell activation (GO:0046643)4.74585314
15macrophage activation involved in immune response (GO:0002281)4.67745346
16response to peptidoglycan (GO:0032494)4.61303157
17antigen processing and presentation of endogenous antigen (GO:0019883)4.61049737
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.54100316
19detection of other organism (GO:0098543)4.40654496
20regulation of gamma-delta T cell differentiation (GO:0045586)4.40414510
21negative regulation of interleukin-12 production (GO:0032695)4.39062119
22positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.32487596
23detection of molecule of bacterial origin (GO:0032490)4.31921115
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.10369148
25positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.05364814
26detection of bacterium (GO:0016045)4.04036883
27detection of external biotic stimulus (GO:0098581)4.01518591
28positive regulation of mast cell activation (GO:0033005)3.99656073
29microglial cell activation (GO:0001774)3.98850399
30negative thymic T cell selection (GO:0045060)3.97200846
31neutrophil activation (GO:0042119)3.94683988
32regulation of interferon-beta biosynthetic process (GO:0045357)3.89800022
33negative T cell selection (GO:0043383)3.85913623
34negative regulation of lymphocyte mediated immunity (GO:0002707)3.81635731
35positive regulation of B cell differentiation (GO:0045579)3.79362387
36regulation of mast cell degranulation (GO:0043304)3.77655535
37B cell receptor signaling pathway (GO:0050853)3.75813421
38immunoglobulin mediated immune response (GO:0016064)3.75642037
39negative regulation of T cell mediated immunity (GO:0002710)3.72431792
40granulocyte activation (GO:0036230)3.69580881
41myeloid cell activation involved in immune response (GO:0002275)3.66559080
42regulation of mast cell activation (GO:0033003)3.66070884
43leukocyte aggregation (GO:0070486)3.66018776
44respiratory burst (GO:0045730)3.65520110
45regulation of mast cell activation involved in immune response (GO:0033006)3.62730339
46macrophage activation (GO:0042116)3.59916646
47regulation of B cell differentiation (GO:0045577)3.59473864
48neutrophil mediated immunity (GO:0002446)3.56189081
49positive regulation of mast cell degranulation (GO:0043306)3.54248055
50positive regulation of mast cell activation involved in immune response (GO:0033008)3.54248055
51detection of biotic stimulus (GO:0009595)3.52428601
52response to host immune response (GO:0052572)3.51645250
53response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.51645250
54positive thymic T cell selection (GO:0045059)3.46734988
55activated T cell proliferation (GO:0050798)3.45472016
56regulation of myeloid leukocyte mediated immunity (GO:0002886)3.39181625
57response to muramyl dipeptide (GO:0032495)3.39178209
58negative regulation of leukocyte mediated immunity (GO:0002704)3.37209359
59regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.34829420
60positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.31969697
61response to interleukin-15 (GO:0070672)3.28943472
62regulation of leukocyte degranulation (GO:0043300)3.25082317
63T cell selection (GO:0045058)3.23250580
64antigen processing and presentation via MHC class Ib (GO:0002475)3.21319708
65positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.21299701
66response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.17010065
67response to host (GO:0075136)3.17010065
68response to host defenses (GO:0052200)3.17010065
69myeloid leukocyte mediated immunity (GO:0002444)3.12876976
70positive T cell selection (GO:0043368)3.11731402
71negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.07908129
72leukocyte migration involved in inflammatory response (GO:0002523)3.07615474
73negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.07445009
74regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.07012891
75regulation of T cell tolerance induction (GO:0002664)3.04446790
76production of molecular mediator involved in inflammatory response (GO:0002532)3.02501492
77positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.02384284
78regulation of tolerance induction (GO:0002643)3.02206301
79interferon-gamma production (GO:0032609)3.01599928
80germinal center formation (GO:0002467)3.00288171
81interferon-gamma-mediated signaling pathway (GO:0060333)2.99423757
82defense response to protozoan (GO:0042832)2.98736239
83regulation of alpha-beta T cell proliferation (GO:0046640)2.98601033
84T cell migration (GO:0072678)2.97319254
85leukocyte degranulation (GO:0043299)2.96621712
86dendritic cell migration (GO:0036336)2.95102293
87regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.93388283
88cellular response to interleukin-15 (GO:0071350)2.92152367
89B cell mediated immunity (GO:0019724)2.91737291
90positive regulation of cellular amide metabolic process (GO:0034250)2.88698628
91dendritic cell chemotaxis (GO:0002407)2.88051927
92myeloid leukocyte activation (GO:0002274)2.87615474
93regulation of antigen processing and presentation (GO:0002577)2.87433581
94negative regulation of erythrocyte differentiation (GO:0045647)2.86913234
95negative regulation of T-helper cell differentiation (GO:0045623)2.85950106
96negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.85950106
97positive regulation of antigen processing and presentation (GO:0002579)2.85250207
98thymic T cell selection (GO:0045061)2.84013275
99negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.81821881
100lipopolysaccharide-mediated signaling pathway (GO:0031663)2.81285207

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.74831717
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.66597438
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.58658585
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.13235622
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.03382352
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.75760938
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.69675187
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.52878298
9RUNX_20019798_ChIP-Seq_JUKART_Human3.04903411
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.94707713
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.93719662
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.82542137
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.79082564
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.74452255
15SPI1_23547873_ChIP-Seq_NB4_Human2.64894445
16SPI1_23127762_ChIP-Seq_K562_Human2.54790349
17VDR_24763502_ChIP-Seq_THP-1_Human2.54717481
18SCL_19346495_ChIP-Seq_HPC-7_Human2.51612789
19MYB_26560356_Chip-Seq_TH2_Human2.49088741
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.45162290
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.43149547
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.39759752
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.33698185
24VDR_21846776_ChIP-Seq_THP-1_Human2.28095825
25VDR_24787735_ChIP-Seq_THP-1_Human2.25954117
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.17301733
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.12601373
28MAF_26560356_Chip-Seq_TH1_Human2.08358365
29MYB_26560356_Chip-Seq_TH1_Human2.03423443
30BRD4_27068464_Chip-Seq_AML-cells_Mouse2.02487078
31STAT4_19710469_ChIP-ChIP_TH1__Mouse2.01564421
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.96549076
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.95370635
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.93597616
35GATA3_27048872_Chip-Seq_THYMUS_Human1.89548354
36UTX_26944678_Chip-Seq_JUKART_Human1.78764267
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.76066257
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.74910301
39MYC_22102868_ChIP-Seq_BL_Human1.72333805
40GATA3_26560356_Chip-Seq_TH2_Human1.59228157
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.56952417
42PU_27001747_Chip-Seq_BMDM_Mouse1.54888617
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52713096
44GATA1_22025678_ChIP-Seq_K562_Human1.52490178
45PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.52303307
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.50879565
47PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50283360
48GATA1_19941827_ChIP-Seq_MEL_Mouse1.50253560
49MAF_26560356_Chip-Seq_TH2_Human1.49985876
50TCF7_22412390_ChIP-Seq_EML_Mouse1.48533847
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45060648
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.41332863
53CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40487859
54SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36083561
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29837640
56GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28764932
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.27192552
58KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26866729
59KDM2B_26808549_Chip-Seq_DND41_Human1.24989160
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21633660
61CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21298382
62GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20785402
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20227512
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20065436
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19926659
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19154465
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17905074
68CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17263841
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16900735
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15139406
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.14591640
72PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13711193
73GATA1_19941826_ChIP-Seq_K562_Human1.13709332
74RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09709941
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09427590
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.05177708
77NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04946489
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02929036
79PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00263726
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99091306
81GATA2_19941826_ChIP-Seq_K562_Human0.96103263
82GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94678887
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94192599
84SMRT_27268052_Chip-Seq_Bcells_Human0.93405119
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93042664
86KDM2B_26808549_Chip-Seq_JURKAT_Human0.87046583
87GATA1_19941827_ChIP-Seq_MEL86_Mouse0.85453112
88STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.82274019
89BCL6_27268052_Chip-Seq_Bcells_Human0.81722630
90PU.1_20513432_ChIP-Seq_Bcells_Mouse0.80256406
91NOTCH1_21737748_ChIP-Seq_TLL_Human0.77020101
92RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75777134
93CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.73883613
94STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.72508768
95ELF1_17652178_ChIP-ChIP_JURKAT_Human0.70874203
96CIITA_25753668_ChIP-Seq_RAJI_Human0.70330342
97SPI1_20517297_ChIP-Seq_HL60_Human0.70281539
98BCOR_27268052_Chip-Seq_Bcells_Human0.68663257
99RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.67400203
100GATA3_26560356_Chip-Seq_TH1_Human0.66919125

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.26695722
2MP0001835_abnormal_antigen_presentation3.83658148
3MP0003436_decreased_susceptibility_to3.77019805
4MP0003303_peritoneal_inflammation3.45167509
5MP0005671_abnormal_response_to3.41355234
6MP0002419_abnormal_innate_immunity3.09001537
7MP0001800_abnormal_humoral_immune2.95935531
8MP0000685_abnormal_immune_system2.79656896
9MP0005000_abnormal_immune_tolerance2.78084534
10MP0006082_CNS_inflammation2.77807878
11MP0001790_abnormal_immune_system2.76334087
12MP0005387_immune_system_phenotype2.76334087
13MP0005025_abnormal_response_to2.69917123
14MP0003172_abnormal_lysosome_physiology2.65442276
15MP0002452_abnormal_antigen_presenting2.62676567
16MP0002723_abnormal_immune_serum2.59133639
17MP0009785_altered_susceptibility_to2.56993067
18MP0002148_abnormal_hypersensitivity_rea2.52257828
19MP0002420_abnormal_adaptive_immunity2.48702814
20MP0001819_abnormal_immune_cell2.46360182
21MP0005464_abnormal_platelet_physiology2.31796177
22MP0003300_gastrointestinal_ulcer2.23409252
23MP0003763_abnormal_thymus_physiology2.15460388
24MP0001533_abnormal_skeleton_physiology2.01940489
25MP0002405_respiratory_system_inflammati1.99047146
26MP0009278_abnormal_bone_marrow1.92962801
27MP0003191_abnormal_cellular_cholesterol1.90268742
28MP0000716_abnormal_immune_system1.88236436
29MP0002398_abnormal_bone_marrow1.87999012
30MP0005058_abnormal_lysosome_morphology1.81087255
31MP0000569_abnormal_digit_pigmentation1.78371860
32MP0005310_abnormal_salivary_gland1.75226424
33MP0001845_abnormal_inflammatory_respons1.73177820
34MP0003828_pulmonary_edema1.72554449
35MP0010155_abnormal_intestine_physiology1.72503046
36MP0005451_abnormal_body_composition1.68469533
37MP0004947_skin_inflammation1.66361393
38MP0009764_decreased_sensitivity_to1.66039142
39MP0000689_abnormal_spleen_morphology1.64750757
40MP0008260_abnormal_autophagy1.63912326
41MP0005397_hematopoietic_system_phenotyp1.59542597
42MP0001545_abnormal_hematopoietic_system1.59542597
43MP0002722_abnormal_immune_system1.52963170
44MP0004381_abnormal_hair_follicle1.49936676
45MP0009333_abnormal_splenocyte_physiolog1.49285755
46MP0002132_abnormal_respiratory_system1.48517133
47MP0002429_abnormal_blood_cell1.46081788
48MP0002998_abnormal_bone_remodeling1.45138631
49MP0004883_abnormal_blood_vessel1.44933109
50MP0003183_abnormal_peptide_metabolism1.43224285
51MP0008469_abnormal_protein_level1.39268025
52MP0000465_gastrointestinal_hemorrhage1.37151114
53MP0000703_abnormal_thymus_morphology1.33872396
54MP0000604_amyloidosis1.30720701
55MP0000015_abnormal_ear_pigmentation1.29464964
56MP0003690_abnormal_glial_cell1.28737888
57MP0003866_abnormal_defecation1.26975967
58MP0002396_abnormal_hematopoietic_system1.26114478
59MP0002166_altered_tumor_susceptibility1.22608674
60MP0001851_eye_inflammation1.20334869
61MP0001853_heart_inflammation1.16648384
62MP0000858_altered_metastatic_potential1.16405810
63MP0003075_altered_response_to1.12625016
64MP0002138_abnormal_hepatobiliary_system1.11292457
65MP0005174_abnormal_tail_pigmentation1.06358106
66MP0001986_abnormal_taste_sensitivity1.06266833
67MP0003656_abnormal_erythrocyte_physiolo1.05323019
68MP0000343_altered_response_to1.04857823
69MP0005164_abnormal_response_to1.04402791
70MP0002009_preneoplasia1.04189881
71MP0005075_abnormal_melanosome_morpholog1.01613928
72MP0002277_abnormal_respiratory_mucosa0.99760706
73MP0008004_abnormal_stomach_pH0.99487367
74MP0003448_altered_tumor_morphology0.97849066
75MP0005167_abnormal_blood-brain_barrier0.97113286
76MP0005166_decreased_susceptibility_to0.85677127
77MP0004130_abnormal_muscle_cell0.83291964
78MP0002006_tumorigenesis0.82260304
79MP0009840_abnormal_foam_cell0.80295271
80MP0000249_abnormal_blood_vessel0.79616918
81MP0001663_abnormal_digestive_system0.78816933
82MP0000371_diluted_coat_color0.77835525
83MP0009763_increased_sensitivity_to0.76167985
84MP0004510_myositis0.75284747
85MP0004808_abnormal_hematopoietic_stem0.74471679
86MP0002933_joint_inflammation0.72538565
87MP0005390_skeleton_phenotype0.70940748
88MP0009765_abnormal_xenobiotic_induced0.69085695
89MP0001873_stomach_inflammation0.68633506
90MP0000920_abnormal_myelination0.68457254
91MP0008874_decreased_physiological_sensi0.66149591
92MP0003045_fibrosis0.65799987
93MP0003795_abnormal_bone_structure0.62840837
94MP0009115_abnormal_fat_cell0.54543355
95MP0000490_abnormal_crypts_of0.53931792
96MP0003329_amyloid_beta_deposits0.53707234
97MP0003091_abnormal_cell_migration0.53080631
98MP0002133_abnormal_respiratory_system0.51832186
99MP0005388_respiratory_system_phenotype0.51832186
100MP0003221_abnormal_cardiomyocyte_apopto0.49328601

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)6.10711006
2Recurrent abscess formation (HP:0002722)6.04867129
3Eczematoid dermatitis (HP:0000976)5.98125842
4Abnormality of macrophages (HP:0004311)5.06886058
5Myositis (HP:0100614)5.00492019
6Orchitis (HP:0100796)4.68164013
7Optic neuritis (HP:0100653)4.62428620
8Retrobulbar optic neuritis (HP:0100654)4.62428620
9Stomatitis (HP:0010280)4.59575316
10Recurrent gram-negative bacterial infections (HP:0005420)4.56414175
11Recurrent fungal infections (HP:0002841)4.47020367
12Recurrent skin infections (HP:0001581)4.11434579
13Mediastinal lymphadenopathy (HP:0100721)4.04319108
14T lymphocytopenia (HP:0005403)3.99984304
15Recurrent cutaneous fungal infections (HP:0011370)3.99449002
16Chronic mucocutaneous candidiasis (HP:0002728)3.99449002
17Spontaneous hematomas (HP:0007420)3.98648832
18Elevated erythrocyte sedimentation rate (HP:0003565)3.93431008
19Meningitis (HP:0001287)3.76645776
20Abnormality of T cell number (HP:0011839)3.72068768
21Obstructive lung disease (HP:0006536)3.59105428
22Chronic obstructive pulmonary disease (HP:0006510)3.59105428
23Gastrointestinal infarctions (HP:0005244)3.58838503
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.53965667
25Increased cerebral lipofuscin (HP:0011813)3.49593952
26Encephalitis (HP:0002383)3.46798384
27Keratoconjunctivitis sicca (HP:0001097)3.46738953
28Abnormality of liposaccharide metabolism (HP:0010968)3.41778969
29Abnormality of glycosphingolipid metabolism (HP:0004343)3.41778969
30Abnormality of glycolipid metabolism (HP:0010969)3.41778969
31Panhypogammaglobulinemia (HP:0003139)3.36230984
32Keratoconjunctivitis (HP:0001096)3.34953930
33Vasculitis (HP:0002633)3.27522004
34Gingivitis (HP:0000230)3.24858565
35Recurrent viral infections (HP:0004429)3.24222151
36Vacuolated lymphocytes (HP:0001922)3.19246116
37Prolonged bleeding time (HP:0003010)3.10886677
38Increased neuronal autofluorescent lipopigment (HP:0002074)3.06549580
39Leukocytosis (HP:0001974)3.05320019
40Hemoptysis (HP:0002105)3.05105787
41Pustule (HP:0200039)3.00846086
42Gingival bleeding (HP:0000225)2.94981093
43Pulmonary infiltrates (HP:0002113)2.94509505
44Abnormality of T cells (HP:0002843)2.92116108
45Urticaria (HP:0001025)2.89503368
46Chest pain (HP:0100749)2.86906953
47Epistaxis (HP:0000421)2.86368783
48Inflammation of the large intestine (HP:0002037)2.82473002
49Hematochezia (HP:0002573)2.68716472
50Arterial thrombosis (HP:0004420)2.67798792
51Gastrointestinal inflammation (HP:0004386)2.64106535
52Granulocytopenia (HP:0001913)2.60047534
53Cellulitis (HP:0100658)2.59078456
54Increased IgE level (HP:0003212)2.53329637
55Pulmonary embolism (HP:0002204)2.50659150
56Dysostosis multiplex (HP:0000943)2.48983308
57Disinhibition (HP:0000734)2.48448877
58Eosinophilia (HP:0001880)2.46141082
59Loss of speech (HP:0002371)2.42391109
60Petechiae (HP:0000967)2.42388469
61Colitis (HP:0002583)2.42020314
62Autoimmune thrombocytopenia (HP:0001973)2.39671781
63Amyloidosis (HP:0011034)2.34188371
64Increased IgM level (HP:0003496)2.29431862
65Episodic fever (HP:0001954)2.28001877
66Anorexia (HP:0002039)2.27940858
67Osteomyelitis (HP:0002754)2.25198955
68Abnormality of eosinophils (HP:0001879)2.19409346
69Lymphopenia (HP:0001888)2.19087458
70Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.16826838
71Purpura (HP:0000979)2.15886238
72Abnormality of T cell physiology (HP:0011840)2.15571260
73Gangrene (HP:0100758)2.11543405
74Agammaglobulinemia (HP:0004432)2.09575081
75Systemic lupus erythematosus (HP:0002725)2.09364895
76Abnormality of the pleura (HP:0002103)2.08822517
77Hypochromic anemia (HP:0001931)2.07300992
78Sepsis (HP:0100806)2.06861430
79Severe combined immunodeficiency (HP:0004430)2.04221970
80Viral hepatitis (HP:0006562)2.00977426
81Abnormality of cells of the lymphoid lineage (HP:0012140)1.99485451
82Vertigo (HP:0002321)1.96719901
83Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.94874506
84Peritonitis (HP:0002586)1.94831127
85Combined immunodeficiency (HP:0005387)1.94777023
86Polyneuropathy (HP:0001271)1.94511454
87Hypochromic microcytic anemia (HP:0004840)1.94234363
88Abnormality of mucopolysaccharide metabolism (HP:0011020)1.93649534
89Abnormality of polysaccharide metabolism (HP:0011012)1.93649534
90Abnormality of glycosaminoglycan metabolism (HP:0004371)1.93649534
91Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.91993111
92Keratitis (HP:0000491)1.91910663
93Hepatosplenomegaly (HP:0001433)1.90559849
94Restrictive lung disease (HP:0002091)1.89891377
95Abnormality of the endocardium (HP:0004306)1.88185681
96Recurrent pneumonia (HP:0006532)1.88125352
97Glomerulopathy (HP:0100820)1.87122728
98Slow saccadic eye movements (HP:0000514)1.86033457
99Papilloma (HP:0012740)1.83407938
100Verrucae (HP:0200043)1.83407938

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.49932937
2BLK4.09011445
3MAP4K13.43203035
4TYK22.83907994
5TXK2.68901802
6IRAK42.63772179
7CSK2.57554214
8FES2.55050180
9MAP3K142.14926831
10MAP2K32.11983893
11ZAP702.01206932
12SYK1.94050407
13PRPF4B1.93533439
14BTK1.90419939
15JAK31.86546299
16GRK61.84133380
17FGR1.84127534
18TAOK31.82467753
19HCK1.75389353
20CSF1R1.74306613
21TNK21.70063224
22MAP3K131.68170440
23ERN11.62418479
24IKBKE1.59942887
25LYN1.50502397
26JAK11.49903293
27ITK1.49110838
28TGFBR21.48781458
29TEC1.43373414
30JAK21.40396055
31CAMKK21.35802702
32YES11.34519126
33MARK31.28707179
34IRAK11.25590102
35LCK1.22601528
36MAP3K31.19378698
37SIK31.18374646
38IKBKB1.15084079
39TBK11.14062573
40KIT1.07875922
41ACVR1B1.07505873
42IRAK21.04190365
43EPHB11.03660667
44TAOK11.03467824
45BMPR20.99676821
46MAP3K110.97495375
47CAMKK10.97420109
48STK100.95606740
49MATK0.95324305
50MAP3K10.95171425
51GRK70.94156823
52FRK0.93673849
53PDK10.93200093
54SIK20.88753432
55PIK3CG0.85568856
56CDK190.84217261
57MARK20.82407087
58PRKD20.75685032
59KSR20.73372308
60CDC42BPA0.73012595
61PDPK10.71677071
62PRKCQ0.70224076
63MAPK70.68698066
64CAMK1D0.68281865
65MAPK120.65833752
66FGFR30.64827798
67PTK2B0.63726735
68NLK0.62686052
69PIM10.61687940
70MAP3K20.60146301
71MAP3K70.57590555
72SGK30.56656541
73FYN0.56352602
74SGK20.55227024
75RPS6KL10.53028133
76RPS6KC10.53028133
77CDK60.52937673
78RPS6KA60.52625940
79DYRK1B0.52599320
80CAMK40.50906700
81MAP3K100.50237768
82PTK60.49031151
83HIPK20.48789308
84ADRBK20.47566742
85STK110.46668307
86EPHA30.44380236
87MAP3K50.44005372
88TAOK20.43055413
89WNK10.42737032
90DAPK20.42663492
91LRRK20.41358232
92NEK90.40199184
93CDK120.39021673
94IRAK30.38633670
95MAP3K60.33458165
96ABL10.33096982
97CHUK0.32837991
98KSR10.32592997
99PRKCH0.31521878
100RAF10.30993472

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.04096546
2Leishmaniasis_Homo sapiens_hsa051402.98680076
3Osteoclast differentiation_Homo sapiens_hsa043802.87641175
4Allograft rejection_Homo sapiens_hsa053302.55796738
5Graft-versus-host disease_Homo sapiens_hsa053322.53884097
6Autoimmune thyroid disease_Homo sapiens_hsa053202.37600094
7B cell receptor signaling pathway_Homo sapiens_hsa046622.30424307
8Primary immunodeficiency_Homo sapiens_hsa053402.27276842
9Tuberculosis_Homo sapiens_hsa051522.24029696
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.05921014
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.99945335
12Asthma_Homo sapiens_hsa053101.97725371
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.97575888
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.93160406
15Hematopoietic cell lineage_Homo sapiens_hsa046401.91547230
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.87872845
17Other glycan degradation_Homo sapiens_hsa005111.86818557
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.85194417
19Type I diabetes mellitus_Homo sapiens_hsa049401.82210564
20T cell receptor signaling pathway_Homo sapiens_hsa046601.74781017
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.73863747
22Antigen processing and presentation_Homo sapiens_hsa046121.65041583
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.64048654
24Chemokine signaling pathway_Homo sapiens_hsa040621.59846697
25Toxoplasmosis_Homo sapiens_hsa051451.56360160
26Malaria_Homo sapiens_hsa051441.55561226
27Lysosome_Homo sapiens_hsa041421.49748820
28Measles_Homo sapiens_hsa051621.49136139
29Legionellosis_Homo sapiens_hsa051341.48895930
30Phagosome_Homo sapiens_hsa041451.47156762
31Acute myeloid leukemia_Homo sapiens_hsa052211.44388667
32Viral myocarditis_Homo sapiens_hsa054161.44027957
33Rheumatoid arthritis_Homo sapiens_hsa053231.39537417
34Influenza A_Homo sapiens_hsa051641.35333482
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.31128315
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29960694
37TNF signaling pathway_Homo sapiens_hsa046681.29643110
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23255200
39Herpes simplex infection_Homo sapiens_hsa051681.21185309
40Platelet activation_Homo sapiens_hsa046111.20882830
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.20623241
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.14987733
43Hepatitis B_Homo sapiens_hsa051611.08727599
44Pertussis_Homo sapiens_hsa051331.07070905
45Non-small cell lung cancer_Homo sapiens_hsa052231.03306362
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.03248907
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96189669
48Apoptosis_Homo sapiens_hsa042100.88012153
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86768292
50Dorso-ventral axis formation_Homo sapiens_hsa043200.85656771
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85116523
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84121114
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82707639
54Hepatitis C_Homo sapiens_hsa051600.80647486
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80365144
56Pancreatic cancer_Homo sapiens_hsa052120.79842589
57African trypanosomiasis_Homo sapiens_hsa051430.78072725
58Salmonella infection_Homo sapiens_hsa051320.75815397
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.73557323
60Chronic myeloid leukemia_Homo sapiens_hsa052200.73463562
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72839282
62Renal cell carcinoma_Homo sapiens_hsa052110.72204268
63Prolactin signaling pathway_Homo sapiens_hsa049170.71820535
64VEGF signaling pathway_Homo sapiens_hsa043700.70702880
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.69364155
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66745802
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66300109
68FoxO signaling pathway_Homo sapiens_hsa040680.65891759
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65452780
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.64569417
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64208679
72Shigellosis_Homo sapiens_hsa051310.61522519
73Epstein-Barr virus infection_Homo sapiens_hsa051690.59947299
74Endocytosis_Homo sapiens_hsa041440.58038769
75Choline metabolism in cancer_Homo sapiens_hsa052310.55709897
76mTOR signaling pathway_Homo sapiens_hsa041500.52619062
77GnRH signaling pathway_Homo sapiens_hsa049120.51031872
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50686805
79HTLV-I infection_Homo sapiens_hsa051660.48374515
80Viral carcinogenesis_Homo sapiens_hsa052030.46793683
81Inositol phosphate metabolism_Homo sapiens_hsa005620.46277911
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.46183213
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45898607
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.45276034
85MAPK signaling pathway_Homo sapiens_hsa040100.43990346
86Notch signaling pathway_Homo sapiens_hsa043300.43898507
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43889017
88Endometrial cancer_Homo sapiens_hsa052130.43287336
89Amoebiasis_Homo sapiens_hsa051460.41937442
90Colorectal cancer_Homo sapiens_hsa052100.40665089
91HIF-1 signaling pathway_Homo sapiens_hsa040660.39865794
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39486979
93Regulation of autophagy_Homo sapiens_hsa041400.38647237
94Insulin resistance_Homo sapiens_hsa049310.35709045
95Type II diabetes mellitus_Homo sapiens_hsa049300.35121435
96ErbB signaling pathway_Homo sapiens_hsa040120.31623911
97Estrogen signaling pathway_Homo sapiens_hsa049150.29648476
98Collecting duct acid secretion_Homo sapiens_hsa049660.29497588
99Complement and coagulation cascades_Homo sapiens_hsa046100.29146993
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28671500

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