ADGRE5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.07404482
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.07404482
3positive regulation of gamma-delta T cell activation (GO:0046645)5.95988699
4antigen processing and presentation of endogenous antigen (GO:0019883)5.91052676
5positive thymic T cell selection (GO:0045059)5.31251008
6regulation of B cell receptor signaling pathway (GO:0050855)5.22572810
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.22035144
8negative regulation of cell killing (GO:0031342)5.22035144
9regulation of gamma-delta T cell differentiation (GO:0045586)5.07109486
10detection of other organism (GO:0098543)4.87692406
11negative T cell selection (GO:0043383)4.75163680
12negative thymic T cell selection (GO:0045060)4.74931829
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.73680623
14detection of bacterium (GO:0016045)4.69899861
15regulation of gamma-delta T cell activation (GO:0046643)4.68397234
16macrophage activation involved in immune response (GO:0002281)4.60636185
17response to peptidoglycan (GO:0032494)4.42460540
18leukocyte aggregation (GO:0070486)4.37331579
19thymic T cell selection (GO:0045061)4.37126274
20negative regulation of lymphocyte mediated immunity (GO:0002707)4.32298660
21positive T cell selection (GO:0043368)4.25805630
22detection of external biotic stimulus (GO:0098581)4.13098637
23T cell migration (GO:0072678)4.03607427
24response to interleukin-15 (GO:0070672)4.01449755
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.98849678
26T cell selection (GO:0045058)3.93646244
27B cell receptor signaling pathway (GO:0050853)3.91395911
28detection of molecule of bacterial origin (GO:0032490)3.90851310
29cellular extravasation (GO:0045123)3.85754975
30negative regulation of leukocyte mediated immunity (GO:0002704)3.84388754
31regulation of T cell tolerance induction (GO:0002664)3.80279968
32regulation of interleukin-12 biosynthetic process (GO:0045075)3.77694072
33negative regulation of T cell mediated immunity (GO:0002710)3.74202864
34response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.73660062
35response to host immune response (GO:0052572)3.73660062
36leukocyte migration involved in inflammatory response (GO:0002523)3.71922447
37interferon-gamma production (GO:0032609)3.71422891
38tolerance induction (GO:0002507)3.71322825
39morphogenesis of an endothelium (GO:0003159)3.66028736
40endothelial tube morphogenesis (GO:0061154)3.66028736
41regulation of B cell differentiation (GO:0045577)3.64540323
42negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.63093966
43detection of biotic stimulus (GO:0009595)3.62210154
44positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.61212008
45cellular response to interleukin-15 (GO:0071350)3.59998288
46microglial cell activation (GO:0001774)3.54603405
47type I interferon signaling pathway (GO:0060337)3.54279149
48cellular response to type I interferon (GO:0071357)3.54279149
49leukocyte cell-cell adhesion (GO:0007159)3.54186132
50response to host (GO:0075136)3.52704239
51response to host defenses (GO:0052200)3.52704239
52response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.52704239
53response to type I interferon (GO:0034340)3.52090405
54regulation of mast cell degranulation (GO:0043304)3.51726370
55myeloid cell activation involved in immune response (GO:0002275)3.50646277
56macrophage activation (GO:0042116)3.37695047
57neutrophil mediated immunity (GO:0002446)3.36148429
58positive regulation of tolerance induction (GO:0002645)3.35949278
59negative regulation of erythrocyte differentiation (GO:0045647)3.35235479
60regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.30605217
61activated T cell proliferation (GO:0050798)3.30564041
62regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.27855636
63regulation of myeloid leukocyte mediated immunity (GO:0002886)3.27301028
64regulation of mast cell activation involved in immune response (GO:0033006)3.21877735
65regulation of T cell mediated cytotoxicity (GO:0001914)3.20513061
66regulation of interferon-beta biosynthetic process (GO:0045357)3.20387126
67negative regulation of phagocytosis (GO:0050765)3.20223985
68T cell costimulation (GO:0031295)3.19233217
69regulation of isotype switching to IgG isotypes (GO:0048302)3.18534330
70response to laminar fluid shear stress (GO:0034616)3.18472866
71positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.18389662
72positive regulation of B cell differentiation (GO:0045579)3.18329523
73regulation of leukocyte degranulation (GO:0043300)3.17474458
74defense response to protozoan (GO:0042832)3.17266420
75positive regulation of T cell mediated cytotoxicity (GO:0001916)3.14949144
76positive regulation of isotype switching (GO:0045830)3.14185560
77leukocyte degranulation (GO:0043299)3.12867359
78positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.12692353
79production of molecular mediator involved in inflammatory response (GO:0002532)3.12611854
80lymphocyte costimulation (GO:0031294)3.11740699
81antigen receptor-mediated signaling pathway (GO:0050851)3.09611976
82negative regulation of innate immune response (GO:0045824)3.06216514
83positive regulation of mast cell activation (GO:0033005)3.05484863
84antigen processing and presentation via MHC class Ib (GO:0002475)3.05111964
85negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.05042403
86negative regulation of T-helper cell differentiation (GO:0045623)3.05042403
87Arp2/3 complex-mediated actin nucleation (GO:0034314)3.04244304
88positive regulation of histone deacetylation (GO:0031065)3.04039404
89regulation of tolerance induction (GO:0002643)3.03563526
90regulation of alpha-beta T cell proliferation (GO:0046640)3.00830215
91positive regulation of lamellipodium assembly (GO:0010592)2.99462257
92regulation of mast cell activation (GO:0033003)2.98925334
93heterotypic cell-cell adhesion (GO:0034113)2.98216977
94B cell mediated immunity (GO:0019724)2.97596498
95positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.97487075
96T cell receptor signaling pathway (GO:0050852)2.94826849
97JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.94108210
98negative regulation of interleukin-6 production (GO:0032715)2.92150357
99negative regulation of type 2 immune response (GO:0002829)2.91076604
100myeloid leukocyte mediated immunity (GO:0002444)2.90001501
101positive regulation of antigen processing and presentation (GO:0002579)2.89820595
102negative regulation of interleukin-12 production (GO:0032695)2.89378904
103lipopolysaccharide-mediated signaling pathway (GO:0031663)2.88741289
104endothelial cell chemotaxis (GO:0035767)2.87417809
105neutrophil activation (GO:0042119)2.80667240
106angiogenesis involved in wound healing (GO:0060055)2.78450171
107pinocytosis (GO:0006907)2.78008345
108establishment of endothelial barrier (GO:0061028)2.77837311
109regulation of response to interferon-gamma (GO:0060330)2.76327469
110negative regulation of granulocyte differentiation (GO:0030853)2.73917116
111positive regulation by symbiont of host defense response (GO:0052509)2.73421834
112modulation by symbiont of host defense response (GO:0052031)2.73421834
113modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.73421834
114modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.73421834
115positive regulation by organism of defense response of other organism involved in symbiotic interact2.73421834
116modulation by symbiont of host immune response (GO:0052553)2.73421834
117regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.73090352
118T cell proliferation (GO:0042098)2.69172598
119regulation of type I interferon-mediated signaling pathway (GO:0060338)2.68083718
120immunoglobulin mediated immune response (GO:0016064)2.67794695
121negative regulation of stress fiber assembly (GO:0051497)2.67472267
122germinal center formation (GO:0002467)2.67170987
123neutrophil activation involved in immune response (GO:0002283)2.66593558
124cellular response to zinc ion (GO:0071294)2.66202894
125positive regulation of immunoglobulin mediated immune response (GO:0002891)2.65831948
126positive regulation of B cell mediated immunity (GO:0002714)2.65831948
127negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.65082336
128regulation of natural killer cell mediated immunity (GO:0002715)2.64964988
129regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.64964988
130NIK/NF-kappaB signaling (GO:0038061)2.64449673
131mannose metabolic process (GO:0006013)2.63996071
132respiratory burst (GO:0045730)2.63764652
133positive regulation of interleukin-2 production (GO:0032743)2.63138764
134interferon-gamma-mediated signaling pathway (GO:0060333)2.62938800
135immune response-activating cell surface receptor signaling pathway (GO:0002429)2.60572901
136regulation of T cell receptor signaling pathway (GO:0050856)2.59348917
137positive regulation of lamellipodium organization (GO:1902745)2.59171733
138leukocyte tethering or rolling (GO:0050901)2.57659658
139negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.56072968
140granulocyte activation (GO:0036230)2.55366119
141positive regulation of DNA recombination (GO:0045911)2.55307827
142natural killer cell activation (GO:0030101)2.55259855
143regulation of dendritic cell antigen processing and presentation (GO:0002604)2.54606725
144regulation of antigen processing and presentation (GO:0002577)2.54447335
145positive regulation of alpha-beta T cell proliferation (GO:0046641)2.54294467
146response to muramyl dipeptide (GO:0032495)2.54289305
147regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.54224190

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.29929717
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.78621536
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.03962730
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.24502201
5MYC_22102868_ChIP-Seq_BL_Human3.14000536
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.13336142
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.12648222
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.11920935
9RUNX_20019798_ChIP-Seq_JUKART_Human3.00236966
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.82010834
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.80136667
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.78951811
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.75367973
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.71734248
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.70091452
16VDR_21846776_ChIP-Seq_THP-1_Human2.61191830
17MAF_26560356_Chip-Seq_TH1_Human2.60344939
18MYB_26560356_Chip-Seq_TH2_Human2.54855096
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.53813545
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.48954983
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.48925901
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.39908582
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.32397649
24UTX_26944678_Chip-Seq_JUKART_Human2.28477501
25MYB_26560356_Chip-Seq_TH1_Human2.23072546
26BRD4_27068464_Chip-Seq_AML-cells_Mouse2.15966773
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.14718602
28TCF7_22412390_ChIP-Seq_EML_Mouse2.13358197
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.12556308
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.10263756
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.99837183
32SCL_19346495_ChIP-Seq_HPC-7_Human1.97744940
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.97023267
34VDR_24763502_ChIP-Seq_THP-1_Human1.95752500
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.90138830
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.87410045
37KDM2B_26808549_Chip-Seq_DND41_Human1.86622193
38SPI1_23547873_ChIP-Seq_NB4_Human1.83993043
39SPI1_23127762_ChIP-Seq_K562_Human1.83409011
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.82196768
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.81542066
42GATA1_22025678_ChIP-Seq_K562_Human1.70422984
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.63777954
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62722962
45MAF_26560356_Chip-Seq_TH2_Human1.59008159
46GATA3_27048872_Chip-Seq_THYMUS_Human1.58269937
47E2F7_22180533_ChIP-Seq_HELA_Human1.53374403
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.53365998
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51125441
50CLOCK_20551151_ChIP-Seq_293T_Human1.49527747
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44715383
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.44344287
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43838955
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.43465547
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40161789
56PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34473063
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34124068
58PU_27001747_Chip-Seq_BMDM_Mouse1.28328937
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28210977
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.27263810
61PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26795522
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25104865
63TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22746139
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22242383
65NCOR1_26117541_ChIP-Seq_K562_Human1.20880384
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20316706
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.19965626
68CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19279578
69CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17618697
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.16701056
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16486696
72KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16129620
73SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15570565
74LXR_22292898_ChIP-Seq_THP-1_Human1.15283276
75PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15161100
76GATA1_19941826_ChIP-Seq_K562_Human1.13975251
77TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13563653
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11640062
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.09161285
80NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08668075
81RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08642811
82PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.08633587
83BCL6_27268052_Chip-Seq_Bcells_Human1.06909357
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05819530
85GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04627246
86FOXO3_23340844_ChIP-Seq_DLD1_Human1.04452032
87SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04080780
88GATA2_19941826_ChIP-Seq_K562_Human1.03923489
89BCOR_27268052_Chip-Seq_Bcells_Human1.03282421
90VDR_24787735_ChIP-Seq_THP-1_Human1.03193499
91SMAD_19615063_ChIP-ChIP_OVARY_Human1.01714537
92TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00952900
93CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00508686
94VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00464988
95FOXM1_23109430_ChIP-Seq_U2OS_Human0.99598041
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99288890
97CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97638035
98GATA3_26560356_Chip-Seq_TH2_Human0.94906856
99STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94656799
100PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94226140
101GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93736730
102IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92320717
103KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91989103
104RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91955277
105RACK7_27058665_Chip-Seq_MCF-7_Human0.90086852
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87063997
107RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.86231600
108SA1_27219007_Chip-Seq_ERYTHROID_Human0.86177400
109SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83234050
110CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82872589
111CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81945381
112PPARA_22158963_ChIP-Seq_LIVER_Mouse0.81907751
113FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.81831383
114ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.81142683
115STAT6_21828071_ChIP-Seq_BEAS2B_Human0.80793016
116HIF1A_21447827_ChIP-Seq_MCF-7_Human0.80668398
117TBX20_22328084_ChIP-Seq_HEART_Mouse0.80327091

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.28261662
2MP0000685_abnormal_immune_system3.11067514
3MP0005387_immune_system_phenotype2.93071064
4MP0001790_abnormal_immune_system2.93071064
5MP0003303_peritoneal_inflammation2.88731293
6MP0001800_abnormal_humoral_immune2.79539623
7MP0005671_abnormal_response_to2.79012140
8MP0003436_decreased_susceptibility_to2.69721736
9MP0003763_abnormal_thymus_physiology2.68814854
10MP0005000_abnormal_immune_tolerance2.49019068
11MP0003300_gastrointestinal_ulcer2.46900296
12MP0002452_abnormal_antigen_presenting2.42178317
13MP0003724_increased_susceptibility_to2.36136268
14MP0002166_altered_tumor_susceptibility2.34666077
15MP0002420_abnormal_adaptive_immunity2.32859336
16MP0001819_abnormal_immune_cell2.29790830
17MP0009785_altered_susceptibility_to2.29565803
18MP0002723_abnormal_immune_serum2.26169586
19MP0005025_abnormal_response_to2.25083129
20MP0002405_respiratory_system_inflammati2.12542436
21MP0002419_abnormal_innate_immunity2.11849957
22MP0002398_abnormal_bone_marrow2.03982205
23MP0000716_abnormal_immune_system1.91437759
24MP0008260_abnormal_autophagy1.89954121
25MP0009333_abnormal_splenocyte_physiolog1.85640485
26MP0001873_stomach_inflammation1.85306135
27MP0002138_abnormal_hepatobiliary_system1.84483047
28MP0005464_abnormal_platelet_physiology1.81072169
29MP0004510_myositis1.79771261
30MP0010368_abnormal_lymphatic_system1.78633062
31MP0009278_abnormal_bone_marrow1.77957938
32MP0002148_abnormal_hypersensitivity_rea1.77422115
33MP0005451_abnormal_body_composition1.77038434
34MP0004947_skin_inflammation1.76723869
35MP0003566_abnormal_cell_adhesion1.76081004
36MP0000689_abnormal_spleen_morphology1.75792430
37MP0010155_abnormal_intestine_physiology1.74220930
38MP0002006_tumorigenesis1.73917429
39MP0000465_gastrointestinal_hemorrhage1.72231603
40MP0006082_CNS_inflammation1.71351569
41MP0001879_abnormal_lymphatic_vessel1.71298052
42MP0002722_abnormal_immune_system1.69407521
43MP0001853_heart_inflammation1.66094513
44MP0002933_joint_inflammation1.65098433
45MP0002396_abnormal_hematopoietic_system1.63767952
46MP0001845_abnormal_inflammatory_respons1.62063108
47MP0002429_abnormal_blood_cell1.59776483
48MP0001533_abnormal_skeleton_physiology1.52972948
49MP0004808_abnormal_hematopoietic_stem1.52195884
50MP0003828_pulmonary_edema1.50649137
51MP0003279_aneurysm1.50312024
52MP0001958_emphysema1.48742632
53MP0003705_abnormal_hypodermis_morpholog1.46674806
54MP0000703_abnormal_thymus_morphology1.46440349
55MP0003448_altered_tumor_morphology1.46043024
56MP0010352_gastrointestinal_tract_polyps1.45824339
57MP0000858_altered_metastatic_potential1.40080352
58MP0005023_abnormal_wound_healing1.39168333
59MP0003191_abnormal_cellular_cholesterol1.38957984
60MP0005397_hematopoietic_system_phenotyp1.37126391
61MP0001545_abnormal_hematopoietic_system1.37126391
62MP0005167_abnormal_blood-brain_barrier1.36928144
63MP0004381_abnormal_hair_follicle1.34041448
64MP0003183_abnormal_peptide_metabolism1.29920721
65MP0005058_abnormal_lysosome_morphology1.29362111
66MP0002277_abnormal_respiratory_mucosa1.23251774
67MP0003091_abnormal_cell_migration1.23203373
68MP0000343_altered_response_to1.23046563
69MP0000767_abnormal_smooth_muscle1.19748213
70MP0003866_abnormal_defecation1.18125844
71MP0002132_abnormal_respiratory_system1.15720831
72MP0000249_abnormal_blood_vessel1.13201010
73MP0008469_abnormal_protein_level1.11730307
74MP0005076_abnormal_cell_differentiation1.10612665
75MP0008438_abnormal_cutaneous_collagen1.07253269
76MP0006054_spinal_hemorrhage1.05174846
77MP0001851_eye_inflammation1.03078686
78MP0003045_fibrosis1.02294051
79MP0002998_abnormal_bone_remodeling1.01375910
80MP0009764_decreased_sensitivity_to0.93538853
81MP0002136_abnormal_kidney_physiology0.85238862
82MP0001663_abnormal_digestive_system0.85085102
83MP0000490_abnormal_crypts_of0.84534828
84MP0003690_abnormal_glial_cell0.83126483
85MP0005166_decreased_susceptibility_to0.82297980
86MP0003453_abnormal_keratinocyte_physiol0.77983899
87MP0008004_abnormal_stomach_pH0.77914674
88MP0000604_amyloidosis0.77805763
89MP0000733_abnormal_muscle_development0.77191790
90MP0008961_abnormal_basal_metabolism0.75993905
91MP0005310_abnormal_salivary_gland0.75877187
92MP0009763_increased_sensitivity_to0.75475185
93MP0009840_abnormal_foam_cell0.74683056
94MP0003075_altered_response_to0.74207594
95MP0002019_abnormal_tumor_incidence0.74077531
96MP0005390_skeleton_phenotype0.73047554
97MP0002128_abnormal_blood_circulation0.72099537
98MP0004883_abnormal_blood_vessel0.70809698
99MP0003656_abnormal_erythrocyte_physiolo0.70682365
100MP0001986_abnormal_taste_sensitivity0.67621849
101MP0005164_abnormal_response_to0.66234161
102MP0002925_abnormal_cardiovascular_devel0.64928333
103MP0002168_other_aberrant_phenotype0.64881141
104MP0004782_abnormal_surfactant_physiolog0.64598595
105MP0003172_abnormal_lysosome_physiology0.64432013
106MP0004185_abnormal_adipocyte_glucose0.64429868
107MP0010630_abnormal_cardiac_muscle0.63909898
108MP0000015_abnormal_ear_pigmentation0.63558320
109MP0000609_abnormal_liver_physiology0.63414794
110MP0003806_abnormal_nucleotide_metabolis0.63094386
111MP0002332_abnormal_exercise_endurance0.62727555
112MP0005075_abnormal_melanosome_morpholog0.62654304
113MP0009765_abnormal_xenobiotic_induced0.61877772
114MP0001614_abnormal_blood_vessel0.61319210
115MP0008874_decreased_physiological_sensi0.61147946
116MP0004084_abnormal_cardiac_muscle0.59831051
117MP0003795_abnormal_bone_structure0.59441169
118MP0002009_preneoplasia0.58505555
119MP0004130_abnormal_muscle_cell0.56594306
120MP0003221_abnormal_cardiomyocyte_apopto0.55679101
121MP0005388_respiratory_system_phenotype0.53232740
122MP0002133_abnormal_respiratory_system0.53232740
123MP0005319_abnormal_enzyme/_coenzyme0.50576436

Predicted human phenotypes

RankGene SetZ-score
1Spontaneous hematomas (HP:0007420)4.74102850
2Eczematoid dermatitis (HP:0000976)4.56971383
3Abnormality of the nasal mucosa (HP:0000433)4.48893942
4Recurrent abscess formation (HP:0002722)4.32422098
5Hematochezia (HP:0002573)3.95927043
6Nasal polyposis (HP:0100582)3.83433327
7T lymphocytopenia (HP:0005403)3.79077961
8Recurrent bronchitis (HP:0002837)3.70486273
9Abnormality of T cell number (HP:0011839)3.66049810
10Pustule (HP:0200039)3.62839050
11Recurrent fungal infections (HP:0002841)3.56899408
12Recurrent viral infections (HP:0004429)3.54121734
13Recurrent gram-negative bacterial infections (HP:0005420)3.50244708
14Myositis (HP:0100614)3.46219715
15Chronic otitis media (HP:0000389)3.42311700
16Recurrent bacterial skin infections (HP:0005406)3.41785671
17Interstitial pulmonary disease (HP:0006530)3.37325807
18Urticaria (HP:0001025)3.32634799
19Cellulitis (HP:0100658)3.32374780
20IgM deficiency (HP:0002850)3.29871646
21Keratoconjunctivitis (HP:0001096)3.28114281
22Elevated erythrocyte sedimentation rate (HP:0003565)3.19979930
23Agammaglobulinemia (HP:0004432)3.10014344
24Inflammation of the large intestine (HP:0002037)3.09842584
25Colitis (HP:0002583)3.03389946
26Gastrointestinal inflammation (HP:0004386)2.97321057
27Papilloma (HP:0012740)2.96929663
28Verrucae (HP:0200043)2.96929663
29Cerebral aneurysm (HP:0004944)2.96352605
30Meningitis (HP:0001287)2.96253630
31Polycythemia (HP:0001901)2.92248767
32Stomatitis (HP:0010280)2.89513975
33Episodic fever (HP:0001954)2.87770423
34Abnormality of T cells (HP:0002843)2.85285931
35Abnormal delayed hypersensitivity skin test (HP:0002963)2.83093547
36Hypochromic anemia (HP:0001931)2.82854175
37Autoimmune thrombocytopenia (HP:0001973)2.78019801
38Increased IgM level (HP:0003496)2.77650974
39Mediastinal lymphadenopathy (HP:0100721)2.76716091
40Peritonitis (HP:0002586)2.74647095
41Aortic aneurysm (HP:0004942)2.69382890
42Hypochromic microcytic anemia (HP:0004840)2.67203633
43Orchitis (HP:0100796)2.66715414
44Prolonged bleeding time (HP:0003010)2.66650369
45Panhypogammaglobulinemia (HP:0003139)2.66322218
46Amyloidosis (HP:0011034)2.65875505
47Abnormality of macrophages (HP:0004311)2.65217267
48Systemic lupus erythematosus (HP:0002725)2.63196637
49Anorexia (HP:0002039)2.63017541
50Obstructive lung disease (HP:0006536)2.60626737
51Chronic obstructive pulmonary disease (HP:0006510)2.60626737
52Recurrent skin infections (HP:0001581)2.56823111
53Vasculitis (HP:0002633)2.54200261
54Chronic mucocutaneous candidiasis (HP:0002728)2.54007423
55Recurrent cutaneous fungal infections (HP:0011370)2.54007423
56Petechiae (HP:0000967)2.51799119
57Emphysema (HP:0002097)2.51749071
58Gingivitis (HP:0000230)2.48059670
59Abnormality of the fingertips (HP:0001211)2.47314184
60Hemoptysis (HP:0002105)2.47313061
61Lymphopenia (HP:0001888)2.44354349
62Arterial thrombosis (HP:0004420)2.44228384
63Leukocytosis (HP:0001974)2.40107517
64Hypergammaglobulinemia (HP:0010702)2.37840668
65Epistaxis (HP:0000421)2.37767663
66Increased density of long bones (HP:0006392)2.37478121
67Abnormality of cells of the lymphoid lineage (HP:0012140)2.36420081
68Gastrointestinal stroma tumor (HP:0100723)2.35885205
69Periodontitis (HP:0000704)2.34862918
70Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.34321622
71Pulmonary embolism (HP:0002204)2.33163052
72Osteolytic defects of the hand bones (HP:0009699)2.32073360
73Osteolytic defects of the phalanges of the hand (HP:0009771)2.32073360
74Combined immunodeficiency (HP:0005387)2.31307323
75Pulmonary infiltrates (HP:0002113)2.29868079
76Osteomyelitis (HP:0002754)2.29768080
77Sepsis (HP:0100806)2.27275800
78Abnormal platelet volume (HP:0011876)2.27133380
79Bronchitis (HP:0012387)2.26963607
80Eosinophilia (HP:0001880)2.26600036
81Optic neuritis (HP:0100653)2.26035257
82Retrobulbar optic neuritis (HP:0100654)2.26035257
83Abnormality of the pleura (HP:0002103)2.23483997
84Thyroiditis (HP:0100646)2.22050814
85Spondylolisthesis (HP:0003302)2.20874743
86Chronic sinusitis (HP:0011109)2.20315134
87Glomerulopathy (HP:0100820)2.19213842
88Gangrene (HP:0100758)2.18742187
89Recurrent sinusitis (HP:0011108)2.17256906
90Myocardial infarction (HP:0001658)2.17173137
91Severe combined immunodeficiency (HP:0004430)2.15568548
92Increased IgE level (HP:0003212)2.15335892
93Restrictive lung disease (HP:0002091)2.15219447
94Aortic dissection (HP:0002647)2.14860345
95Abnormality of the peritoneum (HP:0002585)2.14298947
96Esophageal varix (HP:0002040)2.14091773
97Increased serum ferritin (HP:0003281)2.12543684
98Vacuolated lymphocytes (HP:0001922)2.11810565
99Chest pain (HP:0100749)2.09177722
100Purpura (HP:0000979)2.09062366
101Autoimmune hemolytic anemia (HP:0001890)2.07494912
102Slow saccadic eye movements (HP:0000514)2.07436598
103Gastrointestinal infarctions (HP:0005244)2.06319885
104Viral hepatitis (HP:0006562)2.05457005
105Skin ulcer (HP:0200042)2.05080654
106Microcytic anemia (HP:0001935)2.05003665
107B lymphocytopenia (HP:0010976)2.04668562
108Abnormality of B cell number (HP:0010975)2.04668562
109Abnormality of the endocardium (HP:0004306)2.02599321
110Abnormality of eosinophils (HP:0001879)2.02554619
111Abnormality of T cell physiology (HP:0011840)2.01676117
112Hepatosplenomegaly (HP:0001433)2.01640021
113Mitral stenosis (HP:0001718)2.01406429
114Premature loss of primary teeth (HP:0006323)2.00836158
115Gingival bleeding (HP:0000225)2.00209871
116Thrombocytosis (HP:0001894)1.95793381
117Keratitis (HP:0000491)1.93934197
118Granulocytopenia (HP:0001913)1.93577727
119IgG deficiency (HP:0004315)1.93001996
120Subacute progressive viral hepatitis (HP:0006572)1.92834686
121Abnormality of the pericardium (HP:0001697)1.92333452
122Loss of speech (HP:0002371)1.92111349
123Abnormal platelet function (HP:0011869)1.92109994
124Impaired platelet aggregation (HP:0003540)1.92109994
125Dysostosis multiplex (HP:0000943)1.91911578
126Encephalitis (HP:0002383)1.91780999
127IgA deficiency (HP:0002720)1.90613730
128Joint swelling (HP:0001386)1.90607509
129Abnormality of iron homeostasis (HP:0011031)1.89157175
130Acne (HP:0001061)1.88979950
131Increased mean platelet volume (HP:0011877)1.88049959
132Acute hepatic failure (HP:0006554)1.87993461
133Keratoconjunctivitis sicca (HP:0001097)1.87373825
134Vertigo (HP:0002321)1.82371339

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.94435509
2STK102.95405103
3TXK2.76898382
4PRPF4B2.76745189
5ERN12.54349366
6TGFBR22.52475592
7TRIB32.46053817
8TYK22.42452469
9GRK62.39054319
10ZAP702.25695378
11MAP3K102.20584684
12ITK2.16934958
13FGFR42.10175768
14TNK22.09738552
15JAK32.09164853
16BLK2.05614133
17CSK2.02256905
18LRRK22.01309376
19JAK11.98260895
20TTN1.98079221
21KDR1.96838907
22PKN21.93144800
23TIE11.88928765
24EPHB11.69495442
25TAOK11.67511838
26TBK11.65813552
27MAP3K141.63507436
28BTK1.54952470
29SIK31.53134826
30FGFR31.51849481
31IKBKE1.50839385
32MAP2K31.48929503
33MAP3K111.48919663
34HCK1.42508691
35TEC1.42468111
36MARK31.37652525
37EEF2K1.36728628
38KIT1.29871795
39LCK1.28037776
40MAP3K11.26151918
41IRAK41.25402641
42SYK1.18596129
43MAP3K131.17916788
44KSR21.16637104
45CDK121.14741716
46RIPK11.14324883
47SMG11.10776323
48PTK61.10760273
49CSF1R1.09948183
50PIM11.09014080
51RPS6KA41.08609984
52MST41.08465916
53NLK1.06543545
54IKBKB1.06336491
55TAOK21.03929414
56IRAK31.03870165
57YES11.01111377
58MARK20.97947869
59PRKCH0.97787262
60CLK10.93907874
61IRAK10.91831283
62FES0.91106032
63BMPR20.87841192
64CAMK1D0.86712742
65SIK20.84741873
66JAK20.81678203
67DMPK0.80825436
68MATK0.80767931
69TGFBR10.78944856
70EPHA30.76962987
71MAP3K60.76643776
72PDPK10.76468935
73HIPK20.76456042
74PAK40.76034379
75CHUK0.75501247
76SIK10.73528322
77PRKCQ0.73142568
78IRAK20.72574000
79LYN0.72326783
80TRPM70.70477293
81CDC42BPA0.68496509
82NEK90.67574903
83MAP3K70.67419240
84TAOK30.66374658
85RIPK40.65787589
86PDGFRB0.64514029
87PTK2B0.64368996
88MYLK0.63031316
89MELK0.57887228
90MAP3K30.57662069
91CAMK1G0.57167556
92MAP3K20.56368394
93PIK3CG0.56044850
94CDK40.55901331
95CDK90.55000255
96CDK60.48995503
97MAP3K50.48966930
98PRKD20.48868671
99STK380.48502335
100STK240.48346825
101MAPK120.48135068
102MOS0.47884745
103BMX0.47461662
104FGR0.47016400
105EGFR0.46753797
106STK40.46188740
107PDGFRA0.45361060
108GRK70.44899467
109PRKD10.44899452
110SGK30.44514531
111GRK10.44189385
112ILK0.43430214
113RAF10.42392513
114RPS6KA60.41941414
115MAP3K80.41540109
116DYRK1B0.41478787
117PDK10.41443254
118CDK190.41327903
119RET0.40936192
120FLT30.40906841
121STK110.39964597
122CAMKK10.38083003
123INSR0.38040337
124MAP2K60.37962714
125ABL10.37815725
126PRKG20.37412396
127FYN0.37118106
128MAPK110.36239585
129MAPKAPK20.35985925
130TESK20.35653165
131MAPK70.34677483
132IGF1R0.34189857
133ALK0.34010403
134RPS6KL10.33116433
135RPS6KC10.33116433
136MAP2K20.30111983

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.55815295
2B cell receptor signaling pathway_Homo sapiens_hsa046622.66021092
3Leishmaniasis_Homo sapiens_hsa051402.60594941
4Staphylococcus aureus infection_Homo sapiens_hsa051502.54991839
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.35296900
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.28713597
7Osteoclast differentiation_Homo sapiens_hsa043802.27903649
8T cell receptor signaling pathway_Homo sapiens_hsa046602.25100212
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.19277882
10Hematopoietic cell lineage_Homo sapiens_hsa046402.17855690
11Leukocyte transendothelial migration_Homo sapiens_hsa046702.15825677
12Antigen processing and presentation_Homo sapiens_hsa046122.15395183
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.14829407
14Measles_Homo sapiens_hsa051621.99821974
15Viral myocarditis_Homo sapiens_hsa054161.89215981
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.76994293
17Graft-versus-host disease_Homo sapiens_hsa053321.76034895
18Type I diabetes mellitus_Homo sapiens_hsa049401.74076850
19Toxoplasmosis_Homo sapiens_hsa051451.66807865
20Malaria_Homo sapiens_hsa051441.64075231
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.52314971
22Platelet activation_Homo sapiens_hsa046111.50800583
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.49241171
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.47208939
25Pertussis_Homo sapiens_hsa051331.44361392
26Chemokine signaling pathway_Homo sapiens_hsa040621.42593712
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.40746909
28Shigellosis_Homo sapiens_hsa051311.40227921
29Acute myeloid leukemia_Homo sapiens_hsa052211.37211599
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37011140
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36745168
32Caffeine metabolism_Homo sapiens_hsa002321.32451219
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30983615
34Tuberculosis_Homo sapiens_hsa051521.29702313
35Other glycan degradation_Homo sapiens_hsa005111.28097597
36Herpes simplex infection_Homo sapiens_hsa051681.27257360
37Chronic myeloid leukemia_Homo sapiens_hsa052201.26734654
38Allograft rejection_Homo sapiens_hsa053301.26582981
39Apoptosis_Homo sapiens_hsa042101.24526100
40Pancreatic cancer_Homo sapiens_hsa052121.21897068
41TNF signaling pathway_Homo sapiens_hsa046681.21453683
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.19854356
43Hepatitis B_Homo sapiens_hsa051611.19498338
44Small cell lung cancer_Homo sapiens_hsa052221.17490596
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17241006
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.10522161
47Influenza A_Homo sapiens_hsa051641.09563955
48Focal adhesion_Homo sapiens_hsa045101.08508180
49Legionellosis_Homo sapiens_hsa051341.04635981
50Salmonella infection_Homo sapiens_hsa051321.03147443
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02633076
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01830545
53Complement and coagulation cascades_Homo sapiens_hsa046100.99780474
54Adherens junction_Homo sapiens_hsa045200.97389436
55Regulation of actin cytoskeleton_Homo sapiens_hsa048100.97353306
56VEGF signaling pathway_Homo sapiens_hsa043700.96523500
57HTLV-I infection_Homo sapiens_hsa051660.94787570
58Proteoglycans in cancer_Homo sapiens_hsa052050.88943778
59Lysosome_Homo sapiens_hsa041420.87815443
60Amoebiasis_Homo sapiens_hsa051460.87745834
61Hepatitis C_Homo sapiens_hsa051600.84774453
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84514561
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83444712
64Notch signaling pathway_Homo sapiens_hsa043300.82684876
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.80933528
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80729062
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80669792
68Insulin resistance_Homo sapiens_hsa049310.80192668
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78088978
70ECM-receptor interaction_Homo sapiens_hsa045120.76700079
71Colorectal cancer_Homo sapiens_hsa052100.73299138
72Autoimmune thyroid disease_Homo sapiens_hsa053200.72989976
73Epstein-Barr virus infection_Homo sapiens_hsa051690.72705432
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72144363
75Endocytosis_Homo sapiens_hsa041440.70666573
76Non-small cell lung cancer_Homo sapiens_hsa052230.69684998
77Viral carcinogenesis_Homo sapiens_hsa052030.69337675
78Renal cell carcinoma_Homo sapiens_hsa052110.67350099
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.66105496
80Rap1 signaling pathway_Homo sapiens_hsa040150.65677138
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64546682
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61089953
83Choline metabolism in cancer_Homo sapiens_hsa052310.60715030
84FoxO signaling pathway_Homo sapiens_hsa040680.59916934
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59362386
86GnRH signaling pathway_Homo sapiens_hsa049120.58305579
87MicroRNAs in cancer_Homo sapiens_hsa052060.57070467
88Asthma_Homo sapiens_hsa053100.55089848
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54206231
90Prolactin signaling pathway_Homo sapiens_hsa049170.52952979
91Pathways in cancer_Homo sapiens_hsa052000.52251398
92HIF-1 signaling pathway_Homo sapiens_hsa040660.51943357
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50541851
94Inositol phosphate metabolism_Homo sapiens_hsa005620.48555088
95Prostate cancer_Homo sapiens_hsa052150.48469918
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48047931
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.47672152
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47081624
99Rheumatoid arthritis_Homo sapiens_hsa053230.43891384
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43734548
101Renin-angiotensin system_Homo sapiens_hsa046140.43724477
102mTOR signaling pathway_Homo sapiens_hsa041500.43687332
103Dorso-ventral axis formation_Homo sapiens_hsa043200.43261366
104ErbB signaling pathway_Homo sapiens_hsa040120.42615132
105Lysine degradation_Homo sapiens_hsa003100.41572700
106Dilated cardiomyopathy_Homo sapiens_hsa054140.40650385
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.40107080
108MAPK signaling pathway_Homo sapiens_hsa040100.39981333
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38558214
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.38021412
111Phagosome_Homo sapiens_hsa041450.37152290
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36544514
113Type II diabetes mellitus_Homo sapiens_hsa049300.35646146
114African trypanosomiasis_Homo sapiens_hsa051430.32948241
115Endometrial cancer_Homo sapiens_hsa052130.32861849
116Thyroid cancer_Homo sapiens_hsa052160.30787513

Most similar genes based on co-expression Upload to Enrichr

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