ADGRF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sphingoid metabolic process (GO:0046519)9.92137009
2keratinization (GO:0031424)8.29431437
3long-chain fatty acid biosynthetic process (GO:0042759)7.78748517
4keratinocyte proliferation (GO:0043616)7.56562948
5sphingosine metabolic process (GO:0006670)7.08106396
6multicellular organismal water homeostasis (GO:0050891)6.84767358
7diol metabolic process (GO:0034311)6.80689437
8keratinocyte differentiation (GO:0030216)6.50635037
9regulation of ruffle assembly (GO:1900027)6.26900869
10peptide cross-linking (GO:0018149)5.95267008
11bundle of His cell to Purkinje myocyte communication (GO:0086069)5.72819567
12water homeostasis (GO:0030104)5.72582147
13linoleic acid metabolic process (GO:0043651)5.66004135
14epidermal cell differentiation (GO:0009913)5.56280624
15regulation of transforming growth factor beta1 production (GO:0032908)5.12042144
16phospholipid scrambling (GO:0017121)5.03640252
17epidermis development (GO:0008544)4.98934442
18cyclooxygenase pathway (GO:0019371)4.88053303
19regulation of cell proliferation involved in kidney development (GO:1901722)4.82973564
20chemical homeostasis within a tissue (GO:0048875)4.68518348
21skin morphogenesis (GO:0043589)4.67064117
22negative regulation of stress fiber assembly (GO:0051497)4.55130424
23cilium or flagellum-dependent cell motility (GO:0001539)4.47831584
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.46875483
25fatty acid elongation (GO:0030497)4.45039247
26positive regulation of interleukin-8 secretion (GO:2000484)4.27060215
27detection of bacterium (GO:0016045)4.25659542
28hair cycle (GO:0042633)4.25598648
29molting cycle (GO:0042303)4.25598648
30ectoderm development (GO:0007398)4.20113361
31G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.20064622
32response to phenylpropanoid (GO:0080184)4.18918070
33cilium movement (GO:0003341)4.17568984
34positive regulation of glomerulus development (GO:0090193)4.13789113
35sperm motility (GO:0030317)4.13665464
36chemosensory behavior (GO:0007635)4.10604629
37surfactant homeostasis (GO:0043129)4.10078510
38lipoxygenase pathway (GO:0019372)4.07560422
39cellular ketone body metabolic process (GO:0046950)4.07059176
40epithelial cilium movement (GO:0003351)4.01097642
41multicellular organism reproduction (GO:0032504)3.98620205
42behavioral response to nicotine (GO:0035095)3.95563230
43positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.88955856
44intermediate filament organization (GO:0045109)3.85965426
45regulation of phospholipase A2 activity (GO:0032429)3.85553037
46regulation of sarcomere organization (GO:0060297)3.85132149
47reflex (GO:0060004)3.82057617
48sphingolipid biosynthetic process (GO:0030148)3.79575164
49regulation of cilium movement (GO:0003352)3.79521696
50axonemal dynein complex assembly (GO:0070286)3.74079560
51intestinal epithelial cell development (GO:0060576)3.71179159
52regulation of female gonad development (GO:2000194)3.69081360
53negative regulation of translation, ncRNA-mediated (GO:0040033)3.68230796
54regulation of translation, ncRNA-mediated (GO:0045974)3.68230796
55negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.68230796
56transmission of nerve impulse (GO:0019226)3.67587389
57ketone body metabolic process (GO:1902224)3.65016369
58acrosome reaction (GO:0007340)3.62350853
59detection of other organism (GO:0098543)3.60688039
60primary alcohol catabolic process (GO:0034310)3.59469022
61detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.59174245
62glucosamine-containing compound catabolic process (GO:1901072)3.59048226
63negative regulation of cell fate specification (GO:0009996)3.56221162
64detection of light stimulus involved in visual perception (GO:0050908)3.52813441
65detection of light stimulus involved in sensory perception (GO:0050962)3.52813441
66phosphatidylserine acyl-chain remodeling (GO:0036150)3.51485175
67regulation of chemokine secretion (GO:0090196)3.48861348
68axoneme assembly (GO:0035082)3.48462607
69membrane depolarization during action potential (GO:0086010)3.46879521
70regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.45199513
71negative regulation of kidney development (GO:0090185)3.43484428
72regulation of glomerulus development (GO:0090192)3.41802751
73negative regulation of actin filament bundle assembly (GO:0032232)3.40627782
74L-fucose catabolic process (GO:0042355)3.40170985
75fucose catabolic process (GO:0019317)3.40170985
76L-fucose metabolic process (GO:0042354)3.40170985
77indolalkylamine metabolic process (GO:0006586)3.34955893
78response to pheromone (GO:0019236)3.33671375
79dendritic spine morphogenesis (GO:0060997)3.28636840
80tryptophan catabolic process (GO:0006569)3.28574045
81indole-containing compound catabolic process (GO:0042436)3.28574045
82indolalkylamine catabolic process (GO:0046218)3.28574045
83regulation of neurotransmitter uptake (GO:0051580)3.28568008
84gamma-aminobutyric acid transport (GO:0015812)3.21967287
85long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.21044803
86negative regulation of smooth muscle cell differentiation (GO:0051151)3.18345326
87phosphatidylinositol acyl-chain remodeling (GO:0036149)3.17341478
88postsynaptic membrane organization (GO:0001941)3.15172051
89protein polyglutamylation (GO:0018095)3.13508551
90regulation of interleukin-8 secretion (GO:2000482)3.08640169
91kynurenine metabolic process (GO:0070189)3.08554164
92cardiolipin metabolic process (GO:0032048)3.07539849
93nonmotile primary cilium assembly (GO:0035058)3.05290368
94NAD biosynthetic process (GO:0009435)3.05021039
95photoreceptor cell maintenance (GO:0045494)3.03013490
96phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.02837469
97positive regulation of chemokine secretion (GO:0090197)3.02760855
98auditory receptor cell stereocilium organization (GO:0060088)3.01391356
99response to misfolded protein (GO:0051788)2.98987575
100calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.98561246
101positive regulation of mitochondrial membrane permeability (GO:0035794)2.97293856
102viral transcription (GO:0019083)2.96980269
103calcium ion-dependent exocytosis (GO:0017156)2.95633887
104phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.94705774
105spinal cord motor neuron differentiation (GO:0021522)2.94652696
106establishment of protein localization to Golgi (GO:0072600)2.93882210
107eyelid development in camera-type eye (GO:0061029)2.93420887
108regulation of hippo signaling (GO:0035330)2.92047383
109positive regulation of meiotic cell cycle (GO:0051446)2.91870295
110tryptophan metabolic process (GO:0006568)2.90606311
111cilium organization (GO:0044782)2.89330558
112membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.88903141
113peristalsis (GO:0030432)2.88640420
114positive regulation of Rho protein signal transduction (GO:0035025)2.87053068
115regulation of natural killer cell differentiation (GO:0032823)2.85321704
116membrane lipid biosynthetic process (GO:0046467)2.85150035
117regulation of mesoderm development (GO:2000380)2.84360510
118primary amino compound metabolic process (GO:1901160)2.84327514
119sperm capacitation (GO:0048240)2.84004377
120regulation of axon regeneration (GO:0048679)2.82576935
121regulation of neuron projection regeneration (GO:0070570)2.82576935
122regulation of endothelial cell chemotaxis (GO:2001026)2.82558583
123alanine transport (GO:0032328)2.81013250
124righting reflex (GO:0060013)2.80148747
125positive regulation of vesicle fusion (GO:0031340)2.80134787
126cilium assembly (GO:0042384)2.80013216
127ethanol metabolic process (GO:0006067)2.77221991
128microtubule polymerization or depolymerization (GO:0031109)2.76647676
129prostaglandin biosynthetic process (GO:0001516)2.76576530
130prostanoid biosynthetic process (GO:0046457)2.76576530
131inner ear receptor stereocilium organization (GO:0060122)2.75391495
132translational termination (GO:0006415)2.75288516
133positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.75203961
134centrosome localization (GO:0051642)2.74990330
135phospholipid efflux (GO:0033700)2.74645488
136fatty-acyl-CoA metabolic process (GO:0035337)2.74645263
137serotonin metabolic process (GO:0042428)2.74291492
138negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.74237342
139arachidonic acid metabolic process (GO:0019369)2.74038897
140positive regulation of sodium ion transmembrane transport (GO:1902307)2.73868790
141regulation of posttranscriptional gene silencing (GO:0060147)2.73366382
142regulation of gene silencing by miRNA (GO:0060964)2.73366382
143regulation of gene silencing by RNA (GO:0060966)2.73366382
144cAMP catabolic process (GO:0006198)2.73012961
145somite rostral/caudal axis specification (GO:0032525)2.72034665
146signal peptide processing (GO:0006465)2.71865222
147nucleoside diphosphate catabolic process (GO:0009134)2.71846934
148reproduction (GO:0000003)2.69992311
149cytoskeletal anchoring at plasma membrane (GO:0007016)2.69497898
150G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.68602851
151transepithelial transport (GO:0070633)2.68385063
152proline transport (GO:0015824)2.67455931
153vocalization behavior (GO:0071625)2.66394521
154neuronal action potential (GO:0019228)2.66373137
155indole-containing compound metabolic process (GO:0042430)2.66312542
156negative regulation of cell fate commitment (GO:0010454)2.64980634
157regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.64173807
158cell communication involved in cardiac conduction (GO:0086065)2.64131814
159exogenous drug catabolic process (GO:0042738)2.63291580
160fusion of sperm to egg plasma membrane (GO:0007342)2.62278621
161drug catabolic process (GO:0042737)2.61535896
162glycine transport (GO:0015816)2.61465351
163sperm-egg recognition (GO:0035036)2.61084132
164negative regulation of calcium ion transport into cytosol (GO:0010523)2.60352135
165calcium ion import (GO:0070509)2.60155500
166regulation of glomerular filtration (GO:0003093)2.58882290
167regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.56937573
168centriole replication (GO:0007099)2.55683918
169monoubiquitinated protein deubiquitination (GO:0035520)2.54889417
170atrioventricular valve morphogenesis (GO:0003181)2.54758122
171retinal cone cell development (GO:0046549)2.54647631
172glutamate receptor signaling pathway (GO:0007215)2.54145790
173regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.53827002
174regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.53827002
175spinal cord development (GO:0021510)2.53617343
176gland morphogenesis (GO:0022612)2.52923033
177regulation of cardioblast differentiation (GO:0051890)2.52632134
178retina layer formation (GO:0010842)2.51936941
179arginine catabolic process (GO:0006527)2.51650579
180microtubule depolymerization (GO:0007019)2.51169193
181protein localization to cilium (GO:0061512)2.50770883
182mammary gland epithelial cell differentiation (GO:0060644)2.49947955
183neural tube formation (GO:0001841)2.49537231
184positive regulation of transforming growth factor beta production (GO:0071636)2.49297186
185regulation of collateral sprouting (GO:0048670)2.48821623
186regulation of microtubule-based movement (GO:0060632)2.48006870
187rhodopsin mediated signaling pathway (GO:0016056)2.46484557
188phosphatidylcholine acyl-chain remodeling (GO:0036151)2.45764499
189unsaturated fatty acid biosynthetic process (GO:0006636)2.45184873
190positive regulation of guanylate cyclase activity (GO:0031284)2.44364959
191cellular potassium ion transport (GO:0071804)2.43876058
192potassium ion transmembrane transport (GO:0071805)2.43876058
193ribosomal small subunit biogenesis (GO:0042274)2.42394192
194ceramide biosynthetic process (GO:0046513)2.41142378
195phosphatidylserine metabolic process (GO:0006658)2.40837877
196positive regulation of cholesterol efflux (GO:0010875)2.40666563
197establishment of planar polarity (GO:0001736)2.40535911
198desmosome organization (GO:0002934)14.1800699
199establishment of skin barrier (GO:0061436)11.1604563
200regulation of water loss via skin (GO:0033561)10.2228894

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.92450501
2EZH2_22144423_ChIP-Seq_EOC_Human6.33426705
3ESR2_21235772_ChIP-Seq_MCF-7_Human2.58336542
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.56575626
5GBX2_23144817_ChIP-Seq_PC3_Human2.53085528
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.45557969
7P63_26484246_Chip-Seq_KERATINOCYTES_Human2.40483660
8SOX9_24532713_ChIP-Seq_HFSC_Mouse2.39639292
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.27080402
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19089671
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15236673
12TP63_17297297_ChIP-ChIP_HaCaT_Human11.0727636
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.96505901
14TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96505901
15ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.86264367
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.78245802
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.77755486
18ZNF217_24962896_ChIP-Seq_MCF-7_Human1.76279686
19P300_19829295_ChIP-Seq_ESCs_Human1.74522218
20REST_21632747_ChIP-Seq_MESCs_Mouse1.73698535
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.72937235
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.72865833
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.71343268
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.70071572
25SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.68507651
26SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.68507651
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67919947
28IGF1R_20145208_ChIP-Seq_DFB_Human1.66738458
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66731070
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.63208594
31SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.62506795
32FUS_26573619_Chip-Seq_HEK293_Human1.62431928
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61718019
34STAT3_23295773_ChIP-Seq_U87_Human1.60711598
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59844149
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.59738950
37TCF4_18268006_ChIP-ChIP_LS174T_Human1.59150899
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58338166
39TP53_18474530_ChIP-ChIP_U2OS_Human1.56891880
40ER_23166858_ChIP-Seq_MCF-7_Human1.54841220
41SOX2_20726797_ChIP-Seq_SW620_Human1.54723092
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54532417
43CBP_20019798_ChIP-Seq_JUKART_Human1.54532417
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.53934961
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52704263
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.51471632
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.51347239
48SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.49903673
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.45641024
50SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.44736103
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.42398068
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42252264
53TCF4_23295773_ChIP-Seq_U87_Human1.41738260
54RNF2_27304074_Chip-Seq_NSC_Mouse1.41456991
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41332659
56EZH2_18974828_ChIP-Seq_MESCs_Mouse1.41257369
57RNF2_18974828_ChIP-Seq_MESCs_Mouse1.41257369
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41140623
59SMAD4_21741376_ChIP-Seq_HESCs_Human1.40069078
60SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.39971458
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39449200
62JARID2_20075857_ChIP-Seq_MESCs_Mouse1.35734317
63AR_21572438_ChIP-Seq_LNCaP_Human1.35565982
64SMAD4_21741376_ChIP-Seq_EPCs_Human1.34111889
65TP63_23658742_ChIP-Seq_EP156T_Human1.33333380
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33166303
67WT1_19549856_ChIP-ChIP_CCG9911_Human1.31721956
68EZH2_27294783_Chip-Seq_ESCs_Mouse1.31180022
69ZNF263_19887448_ChIP-Seq_K562_Human1.31050167
70TP53_16413492_ChIP-PET_HCT116_Human1.30163833
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28815174
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27982625
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.27431954
74SMAD3_21741376_ChIP-Seq_ESCs_Human1.27350288
75RUNX2_22187159_ChIP-Seq_PCA_Human1.26778353
76MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26143336
77FLI1_27457419_Chip-Seq_LIVER_Mouse1.25878350
78BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.24305585
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23648853
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22846712
81EWS_26573619_Chip-Seq_HEK293_Human1.22066467
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21268264
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.20539258
84RUNX1_27514584_Chip-Seq_MCF-7_Human1.20459675
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20344670
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20257407
87CJUN_26792858_Chip-Seq_BT549_Human1.17958979
88NANOG_19829295_ChIP-Seq_ESCs_Human1.16825777
89SOX2_19829295_ChIP-Seq_ESCs_Human1.16825777
90TP53_20018659_ChIP-ChIP_R1E_Mouse1.15390427
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15335952
92REST_18959480_ChIP-ChIP_MESCs_Mouse1.15220983
93CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.14237123
94RNF2_27304074_Chip-Seq_ESCs_Mouse1.14101003
95KDM2B_26808549_Chip-Seq_REH_Human1.13314307
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12962335
97KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11886960
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11194856
99CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10417537
100MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10264856
101SOX2_21211035_ChIP-Seq_LN229_Gbm1.09416612
102NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09030161
103BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08035153
104P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06300550
105KLF5_25053715_ChIP-Seq_YYC3_Human1.06265705
106TAF15_26573619_Chip-Seq_HEK293_Human1.05518565
107RXR_22108803_ChIP-Seq_LS180_Human1.05358969
108TP63_22573176_ChIP-Seq_HFKS_Human1.04275528
109RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01461637
110GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.01191603
111AR_19668381_ChIP-Seq_PC3_Human1.00923725
112ESR1_20079471_ChIP-ChIP_T-47D_Human1.00826211
113KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98741612
114TCF4_22108803_ChIP-Seq_LS180_Human0.98119934
115HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96432729
116KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96187222
117TBL1_22424771_ChIP-Seq_293T_Human0.96177891
118MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95224464
119GATA3_21878914_ChIP-Seq_MCF-7_Human0.94885293
120ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94164144
121PIAS1_25552417_ChIP-Seq_VCAP_Human0.94084001
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93945904
123SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93385027
124SMAD_19615063_ChIP-ChIP_OVARY_Human0.93340498
125FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93062452
126DROSHA_22980978_ChIP-Seq_HELA_Human0.91801913
127SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91574724
128ERA_21632823_ChIP-Seq_H3396_Human0.91258674
129CBX2_27304074_Chip-Seq_ESCs_Mouse0.91141264
130RARG_19884340_ChIP-ChIP_MEFs_Mouse0.89465726
131AHR_22903824_ChIP-Seq_MCF-7_Human0.88617936
132BCAT_22108803_ChIP-Seq_LS180_Human0.87655907
133GATA4_25053715_ChIP-Seq_YYC3_Human0.87047727
134GATA6_21074721_ChIP-Seq_CACO-2_Human0.86739047
135SMAD3_21741376_ChIP-Seq_HESCs_Human0.86159032
136FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85768385
137PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.85202417
138CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85148859
139VDR_22108803_ChIP-Seq_LS180_Human0.82065305
140STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.81967109
141LXR_22292898_ChIP-Seq_THP-1_Human0.81889015
142ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.81649247
143ARNT_22903824_ChIP-Seq_MCF-7_Human0.81157265
144GATA3_24758297_ChIP-Seq_MCF-7_Human0.81060894
145ZNF274_21170338_ChIP-Seq_K562_Hela0.80667535
146PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79717164
147AR_25329375_ChIP-Seq_VCAP_Human0.78807758
148OCT1_27270436_Chip-Seq_PROSTATE_Human0.78394341
149NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.77700301
150NRF2_20460467_ChIP-Seq_MEFs_Mouse0.77700301
151ATF3_27146783_Chip-Seq_COLON_Human0.76486795
152RACK7_27058665_Chip-Seq_MCF-7_Human0.76286306
153FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.74574791
154SOX2_27498859_Chip-Seq_STOMACH_Mouse0.74570455
155SA1_27219007_Chip-Seq_Bcells_Human0.74209396
156CDX2_20551321_ChIP-Seq_CACO-2_Human0.73754143
157GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73412007
158CTBP2_25329375_ChIP-Seq_LNCAP_Human0.72246351
159WT1_25993318_ChIP-Seq_PODOCYTE_Human0.70975496
160CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.69580709
161CEBPB_22108803_ChIP-Seq_LS180_Human0.68472639
162SMAD4_21799915_ChIP-Seq_A2780_Human0.68149624
163FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.67940945

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.28997621
2MP0003941_abnormal_skin_development5.64640905
3MP0010234_abnormal_vibrissa_follicle5.32641014
4MP0005501_abnormal_skin_physiology5.23352736
5MP0005275_abnormal_skin_tensile4.92320652
6MP0004381_abnormal_hair_follicle4.55934521
7MP0005451_abnormal_body_composition3.84529948
8MP0003453_abnormal_keratinocyte_physiol3.70694040
9MP0003646_muscle_fatigue3.53878358
10MP0002060_abnormal_skin_morphology3.47110761
11MP0010771_integument_phenotype3.38365406
12MP0001216_abnormal_epidermal_layer3.09267253
13MP0000647_abnormal_sebaceous_gland3.00721559
14MP0002009_preneoplasia2.75107877
15MP0003878_abnormal_ear_physiology2.57112224
16MP0005377_hearing/vestibular/ear_phenot2.57112224
17MP0004947_skin_inflammation2.47333393
18MP0001501_abnormal_sleep_pattern2.47317364
19MP0010386_abnormal_urinary_bladder2.45439749
20MP0002098_abnormal_vibrissa_morphology2.37822709
21MP0005423_abnormal_somatic_nervous2.35152758
22MP0000377_abnormal_hair_follicle2.33434334
23MP0003890_abnormal_embryonic-extraembry2.27699752
24MP0002638_abnormal_pupillary_reflex2.27673239
25MP0005410_abnormal_fertilization2.25903147
26MP0001485_abnormal_pinna_reflex2.23900959
27MP0005551_abnormal_eye_electrophysiolog2.22332521
28MP0003011_delayed_dark_adaptation2.18833407
29MP0006276_abnormal_autonomic_nervous2.16452816
30MP0010678_abnormal_skin_adnexa2.14609332
31MP0000566_synostosis2.10641928
32MP0009745_abnormal_behavioral_response2.07177872
33MP0004133_heterotaxia2.06189097
34MP0003283_abnormal_digestive_organ2.05617333
35MP0004142_abnormal_muscle_tone2.02275254
36MP0004043_abnormal_pH_regulation1.95825170
37MP0009379_abnormal_foot_pigmentation1.87626255
38MP0001243_abnormal_dermal_layer1.82346997
39MP0000579_abnormal_nail_morphology1.80977975
40MP0002653_abnormal_ependyma_morphology1.78865344
41MP0005645_abnormal_hypothalamus_physiol1.73910366
42MP0008872_abnormal_physiological_respon1.72259249
43MP0001486_abnormal_startle_reflex1.64952070
44MP0002272_abnormal_nervous_system1.64160921
45MP0003119_abnormal_digestive_system1.62715729
46MP0002572_abnormal_emotion/affect_behav1.62182148
47MP0000467_abnormal_esophagus_morphology1.61928139
48MP0002735_abnormal_chemical_nociception1.61468793
49MP0000026_abnormal_inner_ear1.58026153
50MP0001440_abnormal_grooming_behavior1.57371858
51MP0001191_abnormal_skin_condition1.55824766
52MP0002102_abnormal_ear_morphology1.52715880
53MP0000631_abnormal_neuroendocrine_gland1.50445625
54MP0002249_abnormal_larynx_morphology1.50431867
55MP0000427_abnormal_hair_cycle1.47362191
56MP0004742_abnormal_vestibular_system1.46678812
57MP0005253_abnormal_eye_physiology1.46503753
58MP0009931_abnormal_skin_appearance1.45210224
59MP0001851_eye_inflammation1.44036390
60MP0003191_abnormal_cellular_cholesterol1.42547803
61MP0003136_yellow_coat_color1.41964966
62MP0006292_abnormal_olfactory_placode1.41831055
63MP0005670_abnormal_white_adipose1.41022313
64MP0001970_abnormal_pain_threshold1.40047838
65MP0002938_white_spotting1.39698418
66MP0004885_abnormal_endolymph1.37863125
67MP0000383_abnormal_hair_follicle1.36766592
68MP0002067_abnormal_sensory_capabilities1.35008840
69MP0003698_abnormal_male_reproductive1.34678484
70MP0001963_abnormal_hearing_physiology1.32420221
71MP0000778_abnormal_nervous_system1.32228428
72MP0002928_abnormal_bile_duct1.32117309
73MP0005167_abnormal_blood-brain_barrier1.31916354
74MP0002733_abnormal_thermal_nociception1.31479887
75MP0002734_abnormal_mechanical_nocicepti1.30141167
76MP0003566_abnormal_cell_adhesion1.29802794
77MP0001348_abnormal_lacrimal_gland1.29249152
78MP0004782_abnormal_surfactant_physiolog1.26148475
79MP0001905_abnormal_dopamine_level1.24757469
80MP0001346_abnormal_lacrimal_gland1.22126951
81MP0002254_reproductive_system_inflammat1.19164425
82MP0002184_abnormal_innervation1.15693830
83MP0001984_abnormal_olfaction1.14922720
84MP0005646_abnormal_pituitary_gland1.13477569
85MP0000367_abnormal_coat/_hair1.13471714
86MP0002752_abnormal_somatic_nervous1.12705789
87MP0000569_abnormal_digit_pigmentation1.11303316
88MP0000955_abnormal_spinal_cord1.11101568
89MP0000762_abnormal_tongue_morphology1.10737137
90MP0003705_abnormal_hypodermis_morpholog1.10485190
91MP0009046_muscle_twitch1.08918515
92MP0002277_abnormal_respiratory_mucosa1.06435395
93MP0001929_abnormal_gametogenesis1.06020012
94MP0003718_maternal_effect1.02611092
95MP0003879_abnormal_hair_cell1.00429887
96MP0001529_abnormal_vocalization1.00056175
97MP0008004_abnormal_stomach_pH1.00055845
98MP0002063_abnormal_learning/memory/cond0.98997726
99MP0002822_catalepsy0.98659706
100MP0004085_abnormal_heartbeat0.96031507
101MP0005195_abnormal_posterior_eye0.95981684
102MP0001340_abnormal_eyelid_morphology0.95217778
103MP0002882_abnormal_neuron_morphology0.94940421
104MP0002229_neurodegeneration0.92290198
105MP0010368_abnormal_lymphatic_system0.91009021
106MP0002138_abnormal_hepatobiliary_system0.89165980
107MP0008961_abnormal_basal_metabolism0.88930866
108MP0003880_abnormal_central_pattern0.88409913
109MP0000537_abnormal_urethra_morphology0.87697143
110MP0002876_abnormal_thyroid_physiology0.87523775
111MP0003137_abnormal_impulse_conducting0.86938667
112MP0005171_absent_coat_pigmentation0.86922839
113MP0003937_abnormal_limbs/digits/tail_de0.86013638
114MP0004147_increased_porphyrin_level0.84711306
115MP0004215_abnormal_myocardial_fiber0.84553885
116MP0002234_abnormal_pharynx_morphology0.83751456
117MP0003950_abnormal_plasma_membrane0.82975758
118MP0009780_abnormal_chondrocyte_physiolo0.82067072
119MP0003045_fibrosis0.80801032
120MP0005386_behavior/neurological_phenoty0.78118613
121MP0004924_abnormal_behavior0.78118613
122MP0000470_abnormal_stomach_morphology0.77098476
123MP0004185_abnormal_adipocyte_glucose0.76018583
124MP0008995_early_reproductive_senescence0.74976556
125MP0008789_abnormal_olfactory_epithelium0.73473931
126MP0001293_anophthalmia0.72334214
127MP0002909_abnormal_adrenal_gland0.72067209
128MP0002090_abnormal_vision0.71948310
129MP0004019_abnormal_vitamin_homeostasis0.71263440
130MP0004264_abnormal_extraembryonic_tissu0.71163391
131MP0002736_abnormal_nociception_after0.71086194
132MP0002210_abnormal_sex_determination0.70695384
133MP0000465_gastrointestinal_hemorrhage0.69861904
134MP0003861_abnormal_nervous_system0.69782528
135MP0003315_abnormal_perineum_morphology0.69732785
136MP0001968_abnormal_touch/_nociception0.68881697
137MP0001177_atelectasis0.67904218
138MP0006035_abnormal_mitochondrial_morpho0.62285741
139MP0004145_abnormal_muscle_electrophysio0.61812345
140MP0002006_tumorigenesis0.61507071
141MP0002177_abnormal_outer_ear0.56883694
142MP0003329_amyloid_beta_deposits0.55491792
143MP0005508_abnormal_skeleton_morphology0.55348346
144MP0002166_altered_tumor_susceptibility0.52126354
145MP0003195_calcinosis0.50976036
146MP0003183_abnormal_peptide_metabolism0.46918910
147MP0001784_abnormal_fluid_regulation0.44708780
148MP0000538_abnormal_urinary_bladder0.40653830
149MP0002282_abnormal_trachea_morphology0.40488166
150MP0002233_abnormal_nose_morphology0.39775581
151MP0000516_abnormal_urinary_system0.37853816
152MP0005367_renal/urinary_system_phenotyp0.37853816
153MP0001299_abnormal_eye_distance/0.33245319
154MP0005623_abnormal_meninges_morphology0.32073072
155MP0005409_darkened_coat_color0.31770996
156MP0002896_abnormal_bone_mineralization0.31427130
157MP0005248_abnormal_Harderian_gland0.29921769
158MP0000372_irregular_coat_pigmentation0.29749347
159MP0006072_abnormal_retinal_apoptosis0.27389254
160MP0004510_myositis0.27243188
161MP0004859_abnormal_synaptic_plasticity0.26752017
162MP0010352_gastrointestinal_tract_polyps0.26642151
163MP0009053_abnormal_anal_canal0.26620912
164MP0002064_seizures0.26196927
165MP0006054_spinal_hemorrhage0.26074867
166MP0005085_abnormal_gallbladder_physiolo0.25849308
167MP0000013_abnormal_adipose_tissue0.25715647
168MP0005076_abnormal_cell_differentiation0.25669487
169MP0002697_abnormal_eye_size0.25512478
170MP0005375_adipose_tissue_phenotype0.24801708
171MP0004272_abnormal_basement_membrane0.23791512
172MP0003635_abnormal_synaptic_transmissio0.23462511
173MP0009384_cardiac_valve_regurgitation0.23250564
174MP0005187_abnormal_penis_morphology0.23168516
175MP0004270_analgesia0.23002425
176MP0002295_abnormal_pulmonary_circulatio0.22923272
177MP0002557_abnormal_social/conspecific_i0.22916103
178MP0000049_abnormal_middle_ear0.22895090

Predicted human phenotypes

RankGene SetZ-score
1Congenital ichthyosiform erythroderma (HP:0007431)9.40039967
2Hypotrichosis (HP:0001006)7.01556328
3Parakeratosis (HP:0001036)7.00826190
4Increased IgE level (HP:0003212)6.86212371
5Right ventricular cardiomyopathy (HP:0011663)6.75711866
6Lip pit (HP:0100267)6.73930750
7Erythema (HP:0010783)6.28274185
8Woolly hair (HP:0002224)5.56349201
9Erythroderma (HP:0001019)5.14433786
10Ectropion (HP:0000656)5.02006402
11Genetic anticipation (HP:0003743)5.01338525
12Abnormality of nail color (HP:0100643)4.56736948
13Gangrene (HP:0100758)4.37438435
14Progressive cerebellar ataxia (HP:0002073)4.34283480
15Hyporeflexia of lower limbs (HP:0002600)4.17745187
16Palmoplantar hyperkeratosis (HP:0000972)4.12917750
17Corneal erosion (HP:0200020)4.10627412
18Pancreatic cysts (HP:0001737)3.89390713
19Abnormality of the axillary hair (HP:0100134)3.89045640
20Abnormality of secondary sexual hair (HP:0009888)3.89045640
21Hypohidrosis (HP:0000966)3.85941879
22Abnormal ciliary motility (HP:0012262)3.84382674
23Absent/shortened dynein arms (HP:0200106)3.84147869
24Dynein arm defect of respiratory motile cilia (HP:0012255)3.84147869
25Palmar hyperkeratosis (HP:0010765)3.81667500
26Pancreatic fibrosis (HP:0100732)3.80560836
27Plantar hyperkeratosis (HP:0007556)3.78395327
28Reticulocytopenia (HP:0001896)3.75873299
29Curly hair (HP:0002212)3.67281876
30Ventricular tachycardia (HP:0004756)3.65033632
31True hermaphroditism (HP:0010459)3.62146963
32Onycholysis (HP:0001806)3.58869107
33Congenital stationary night blindness (HP:0007642)3.53507355
34Abnormal respiratory motile cilium morphology (HP:0005938)3.51740784
35Abnormal respiratory epithelium morphology (HP:0012253)3.51740784
36Nephronophthisis (HP:0000090)3.51345871
37Chronic hepatic failure (HP:0100626)3.49247415
38Abnormal respiratory motile cilium physiology (HP:0012261)3.47559422
39Pruritus (HP:0000989)3.44514571
40Decreased central vision (HP:0007663)3.42919263
41Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.30767550
42Natal tooth (HP:0000695)3.29770633
43Attenuation of retinal blood vessels (HP:0007843)3.29365807
44Sclerocornea (HP:0000647)3.28533203
45Gaze-evoked nystagmus (HP:0000640)3.26736790
46Abnormal blistering of the skin (HP:0008066)3.25490788
47Advanced eruption of teeth (HP:0006288)3.25182420
48Popliteal pterygium (HP:0009756)3.23313373
49Severe visual impairment (HP:0001141)3.22415569
50Ulnar claw (HP:0001178)3.16890413
51Oligodontia (HP:0000677)3.15989450
52Abnormality of the salivary glands (HP:0010286)3.15455850
53Abnormality of the renal medulla (HP:0100957)3.14223281
54Retinal dysplasia (HP:0007973)3.11931090
55Bony spicule pigmentary retinopathy (HP:0007737)3.04562860
56Decreased circulating renin level (HP:0003351)3.04308372
57Acanthosis nigricans (HP:0000956)3.03065859
58Palmoplantar keratoderma (HP:0000982)3.01349947
59Cystic liver disease (HP:0006706)2.98472332
60Distal lower limb muscle weakness (HP:0009053)2.97135613
61Abnormality of midbrain morphology (HP:0002418)2.96161997
62Molar tooth sign on MRI (HP:0002419)2.96161997
63Abnormal drinking behavior (HP:0030082)2.94525230
64Polydipsia (HP:0001959)2.94525230
65Asymmetry of the thorax (HP:0001555)2.93106022
66Areflexia of lower limbs (HP:0002522)2.89469458
67Sparse eyelashes (HP:0000653)2.88964046
68Abnormal rod and cone electroretinograms (HP:0008323)2.82072479
69Concave nail (HP:0001598)2.80836950
70Hyperventilation (HP:0002883)2.76178891
71Fragile nails (HP:0001808)2.73089958
72Lack of skin elasticity (HP:0100679)2.72202548
73Abnormality of the pubic bones (HP:0003172)2.69611921
74Dehydration (HP:0001944)2.68892279
75Hypoplastic labia majora (HP:0000059)2.68211159
76Abnormality of the renal cortex (HP:0011035)2.67405135
77Hyperkalemia (HP:0002153)2.64819472
78Tubular atrophy (HP:0000092)2.62583571
79Dry skin (HP:0000958)2.62216430
80Abolished electroretinogram (ERG) (HP:0000550)2.61579930
81Sparse scalp hair (HP:0002209)2.61035666
82Rhinitis (HP:0012384)2.58334234
83Ventricular fibrillation (HP:0001663)2.50561700
84Abnormality of macular pigmentation (HP:0008002)2.50539045
85Diplopia (HP:0000651)2.48717267
86Abnormality of binocular vision (HP:0011514)2.48717267
87Paralysis (HP:0003470)2.47372283
88Bifid scrotum (HP:0000048)2.47101380
89Oligodactyly (hands) (HP:0001180)2.45655515
90Abnormality of the labia majora (HP:0012881)2.41578823
91Congenital hepatic fibrosis (HP:0002612)2.39151904
92Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.31702159
93Broad-based gait (HP:0002136)2.31102696
94Clumsiness (HP:0002312)2.29758921
95Increased corneal curvature (HP:0100692)2.29743622
96Keratoconus (HP:0000563)2.29743622
97Focal motor seizures (HP:0011153)2.29266866
98Hypoplastic nipples (HP:0002557)2.21496326
99Skin pits (HP:0100276)2.19297494
100Medial flaring of the eyebrow (HP:0010747)2.17731151
101Anhidrosis (HP:0000970)2.16633347
102Pustule (HP:0200039)2.15786409
103Type II lissencephaly (HP:0007260)2.14888087
104Hypoplastic ischia (HP:0003175)2.14887355
105Polyuria (HP:0000103)2.14187323
106Optic nerve hypoplasia (HP:0000609)2.10868582
107Anencephaly (HP:0002323)2.08565675
108Sudden death (HP:0001699)2.08406238
109Abnormality of the ischium (HP:0003174)2.07729185
110Focal seizures (HP:0007359)2.07391367
111Dialeptic seizures (HP:0011146)2.06490135
112Abdominal situs inversus (HP:0003363)2.05012144
113Abnormality of abdominal situs (HP:0011620)2.05012144
114Narrow nasal bridge (HP:0000446)2.04077202
115Abnormality of renin-angiotensin system (HP:0000847)2.02606639
116Congenital sensorineural hearing impairment (HP:0008527)2.01447237
117Abnormal biliary tract physiology (HP:0012439)2.01355824
118Bile duct proliferation (HP:0001408)2.01355824
119Aplasia/Hypoplasia of the tongue (HP:0010295)2.01289904
120Brittle hair (HP:0002299)2.00273271
121Hypergammaglobulinemia (HP:0010702)2.00220172
122Congenital nonbullous ichthyosiform erythroderma (HP:0007479)10.0455882
123Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.99938674
124Absent speech (HP:0001344)1.99513644
125Febrile seizures (HP:0002373)1.98855285
126Epileptic encephalopathy (HP:0200134)1.97851614
127Type I diabetes mellitus (HP:0100651)1.97787076
128Inability to walk (HP:0002540)1.96550626
129Abnormality of the gastric mucosa (HP:0004295)1.95342284
130Cerebellar dysplasia (HP:0007033)1.94433629
131Duplicated collecting system (HP:0000081)1.93350538
132Abnormality of small intestinal villus morphology (HP:0011472)1.93001550
133Villous atrophy (HP:0011473)1.93001550
134Genital tract atresia (HP:0001827)1.92846191
135Absent rod-and cone-mediated responses on ERG (HP:0007688)1.91846696
136Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.91097465
137Septo-optic dysplasia (HP:0100842)1.90716590
138Atonic seizures (HP:0010819)1.88396030
139Vaginal atresia (HP:0000148)1.88047572
140Nail dystrophy (HP:0008404)1.86972983
141Bronchiectasis (HP:0002110)1.86127397
142Protruding tongue (HP:0010808)1.84399367
143Palpebral edema (HP:0100540)1.83396719
144Gait imbalance (HP:0002141)1.82811898
145Conjunctival hamartoma (HP:0100780)1.82784727
146Sex reversal (HP:0012245)1.82244550
147Abnormal sex determination (HP:0012244)1.82244550
148Labial hypoplasia (HP:0000066)1.82054482
149Abnormal hemoglobin (HP:0011902)1.82041717
150Hypoplasia of the iris (HP:0007676)1.81258667
151Occipital encephalocele (HP:0002085)1.81230294
152Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80305414
153Chronic bronchitis (HP:0004469)1.80285821
154Testicular atrophy (HP:0000029)1.80032798
155Abnormal urine output (HP:0012590)1.79940261
156Tubulointerstitial abnormality (HP:0001969)1.79939855
157Pterygium (HP:0001059)1.79732840
158Everted lower lip vermilion (HP:0000232)1.78591794
159Furrowed tongue (HP:0000221)1.77708000
160Corneal dystrophy (HP:0001131)1.77668341
161Postaxial foot polydactyly (HP:0001830)1.76320733
162Anophthalmia (HP:0000528)1.75762696
163Sepsis (HP:0100806)1.75618320
164Aplasia cutis congenita (HP:0001057)1.75381043
165Breast hypoplasia (HP:0003187)1.73776349
166Autoimmune thrombocytopenia (HP:0001973)1.73408388
167Aplasia/Hypoplasia of the fovea (HP:0008060)1.73330355
168Hypoplasia of the fovea (HP:0007750)1.73330355
169Preauricular pit (HP:0004467)1.70555809
170Periauricular skin pits (HP:0100277)1.70555809
171Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.70553949
172Calf muscle hypertrophy (HP:0008981)1.70271039
173Pendular nystagmus (HP:0012043)1.69245045
174Male pseudohermaphroditism (HP:0000037)1.67731531
175Hyperaldosteronism (HP:0000859)1.66890168
176Tubulointerstitial fibrosis (HP:0005576)1.66814041
177Ectopic kidney (HP:0000086)1.66560939
178Absence seizures (HP:0002121)1.66376666
179Hypodontia (HP:0000668)1.65960141
180Muscle hypertrophy of the lower extremities (HP:0008968)1.65866073
181Prostate neoplasm (HP:0100787)1.65847201
182Hypoplastic female external genitalia (HP:0012815)1.65131508
183Conical tooth (HP:0000698)1.63847463
184Abnormality of the renal collecting system (HP:0004742)1.61437918
185Steppage gait (HP:0003376)1.60849519
186Hoarse voice (HP:0001609)1.60527761
187Macrocytic anemia (HP:0001972)1.59211363
188Absent hair (HP:0002298)1.58488776
189Abnormality of cells of the erythroid lineage (HP:0012130)1.58415651
190Severe Myopia (HP:0011003)1.58255078
191Congenital, generalized hypertrichosis (HP:0004540)1.56413430
192Thick nail (HP:0001805)1.56376283
193Pili torti (HP:0003777)1.55162640
194Tapered finger (HP:0001182)1.53847298
195Pallor (HP:0000980)1.53536850
196Congenital malformation of the right heart (HP:0011723)1.51462328

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.06409270
2MST45.90241993
3MAPKAPK35.65218953
4FER4.29272520
5BMPR1B3.44459249
6BLK3.35802910
7RPS6KB23.13858071
8WNK42.99566368
9ACVR1B2.72344537
10BCR2.56733438
11WNK32.55442736
12SIK22.50426286
13MAP3K32.42817467
14RIPK42.38394068
15EPHB22.35848549
16LATS12.35317522
17TNK22.18216636
18STK392.16269037
19MAPKAPK52.14331703
20ADRBK22.11905422
21ZAK2.11487742
22PINK11.96745829
23MAP3K21.95400291
24TNIK1.93044508
25MAP3K121.76863243
26STK38L1.74867060
27MAPK131.72185857
28MAPK151.66854593
29PNCK1.64568590
30MAP3K41.63299104
31RIPK11.55858507
32TRPM71.55094493
33LIMK11.55076607
34LRRK21.54892705
35TAOK31.44994761
36EPHA41.44554547
37STK101.42555184
38NTRK31.41426019
39CASK1.39084606
40CAMK1D1.31123143
41CAMK1G1.30089407
42TGFBR11.28650537
43MAP4K21.27515402
44DAPK21.21480128
45MAP3K111.20794083
46MAP2K41.18967522
47PLK41.14743513
48PIM21.14362018
49OBSCN1.13347414
50NUAK11.12687021
51PTK61.10757379
52MAP3K141.10099119
53PKN11.05381573
54BMPR21.04468255
55ERBB31.04015153
56GRK11.03327158
57MKNK21.03245344
58PASK1.01771344
59WNK11.01662353
60MAP3K61.00724753
61DYRK1B0.99686393
62MAP2K70.98279286
63MST1R0.96457822
64TESK10.93543265
65TAOK10.92602451
66CAMK10.90736211
67DYRK1A0.90586696
68NTRK20.90038775
69STK380.86290076
70PHKG10.83119183
71PHKG20.83119183
72CAMK40.78487049
73PRKCE0.78026599
74PTK2B0.75316528
75PRKD30.74825674
76MAP3K10.74408230
77LATS20.73758647
78PRKD10.73320283
79DYRK20.73073776
80CDK50.72725076
81PRKAA10.71817613
82PIK3CA0.69861979
83PAK30.69658494
84YES10.67698991
85ITK0.66120114
86PRKCQ0.65523010
87CCNB10.64731038
88PRPF4B0.64131579
89NEK20.63786247
90ADRBK10.63513751
91PRKAA20.63268946
92WEE10.62982591
93PRKCH0.62725097
94PRKCI0.60367116
95GRK50.58689940
96RPS6KA60.58679634
97CAMKK10.55711971
98PLK20.54136848
99GRK70.53165414
100CHEK20.52476928
101TLK10.51398130
102ROCK10.50264739
103CSNK1D0.48489235
104ROCK20.48238098
105NLK0.47723581
106NEK60.47692623
107STK110.47221442
108MINK10.47141921
109MAPK120.46619244
110CAMKK20.46033691
111MAP2K60.45408697
112EPHA30.44666018
113KIT0.44024842
114FGFR20.43255975
115TAOK20.43082029
116AURKA0.42388131
117STK30.41960189
118MAP3K70.41746960
119IKBKB0.40889103
120MAPKAPK20.39511078
121IRAK10.39170699
122MARK10.39116997
123PIK3CG0.39053400
124SIK30.38656581
125SIK10.38525981
126DDR20.38366178
127TXK0.38189664
128MAP3K90.38097505
129ERBB40.37816105
130EIF2AK20.36347923
131ERBB20.36315675
132FES0.34339924
133SYK0.32731002
134CDC70.32668291
135NTRK10.32442790
136CAMK2A0.31981308
137STK240.30993511
138CDK30.30932460
139SRC0.30893690
140PRKCA0.29439807
141MAPK40.28499740
142OXSR10.28393179
143DMPK0.28326985
144FYN0.27742352
145MAPK90.27381911
146MAP3K50.27294980
147SGK10.26295610
148CDK190.26035948
149ABL10.25868382
150FGFR40.25837336
151CDK60.25799969
152VRK10.25437240
153CHUK0.25288198
154PLK10.24986836
155PRKCZ0.24479376
156LMTK20.24444408
157PRKCG0.24276795
158INSRR0.23651917
159PRKACB0.23196976
160PRKACA0.23169214
161BRAF0.23058232
162RPS6KA10.22897771
163BRD40.22836214
164CSNK1A10.22190110
165RPS6KL10.22171777
166RPS6KC10.22171777
167PRKG10.21916109
168CSNK1E0.21350876
169PRKCB0.21211708

Predicted pathways (KEGG)

RankGene SetZ-score
1Sphingolipid metabolism_Homo sapiens_hsa006004.33652426
2Collecting duct acid secretion_Homo sapiens_hsa049663.03153971
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.01828786
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.74865073
5Linoleic acid metabolism_Homo sapiens_hsa005912.73307774
6Arachidonic acid metabolism_Homo sapiens_hsa005902.71215739
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.61285219
8Butanoate metabolism_Homo sapiens_hsa006502.52295926
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.48228576
10Phenylalanine metabolism_Homo sapiens_hsa003602.25748457
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.21792619
12Cyanoamino acid metabolism_Homo sapiens_hsa004602.04854093
13Ribosome_Homo sapiens_hsa030101.89468697
14Ether lipid metabolism_Homo sapiens_hsa005651.88956460
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.68666918
16Histidine metabolism_Homo sapiens_hsa003401.68031235
17Nitrogen metabolism_Homo sapiens_hsa009101.65339297
18Synaptic vesicle cycle_Homo sapiens_hsa047211.64432758
19Fatty acid elongation_Homo sapiens_hsa000621.64157054
20Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.63183993
21Tryptophan metabolism_Homo sapiens_hsa003801.60026720
22Vibrio cholerae infection_Homo sapiens_hsa051101.58349773
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58105160
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.52888955
25Renin secretion_Homo sapiens_hsa049241.50206144
26Serotonergic synapse_Homo sapiens_hsa047261.49476147
27Axon guidance_Homo sapiens_hsa043601.42260450
28Sphingolipid signaling pathway_Homo sapiens_hsa040711.40224905
29Caffeine metabolism_Homo sapiens_hsa002321.37061689
30Selenocompound metabolism_Homo sapiens_hsa004501.36061169
31Tyrosine metabolism_Homo sapiens_hsa003501.35066944
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.29802564
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.28273538
34Tight junction_Homo sapiens_hsa045301.25531564
35Gastric acid secretion_Homo sapiens_hsa049711.20994939
36Salivary secretion_Homo sapiens_hsa049701.20639871
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16733682
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16184716
39Pancreatic secretion_Homo sapiens_hsa049721.15391631
40Glutamatergic synapse_Homo sapiens_hsa047241.13055656
41Chemical carcinogenesis_Homo sapiens_hsa052041.12879301
42ErbB signaling pathway_Homo sapiens_hsa040121.12698249
43Vitamin digestion and absorption_Homo sapiens_hsa049771.11008360
44Circadian entrainment_Homo sapiens_hsa047131.09196916
45Nicotine addiction_Homo sapiens_hsa050331.08875358
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08524296
47Homologous recombination_Homo sapiens_hsa034401.07436866
48Olfactory transduction_Homo sapiens_hsa047401.06499151
49VEGF signaling pathway_Homo sapiens_hsa043701.06399717
50ABC transporters_Homo sapiens_hsa020101.04912106
51Long-term potentiation_Homo sapiens_hsa047201.02835897
52Vascular smooth muscle contraction_Homo sapiens_hsa042701.02344830
53Retinol metabolism_Homo sapiens_hsa008301.02001464
54GnRH signaling pathway_Homo sapiens_hsa049121.01231116
55Lysine degradation_Homo sapiens_hsa003100.98704685
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98447254
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98346676
58Amphetamine addiction_Homo sapiens_hsa050310.95693022
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95011485
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94371623
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94059060
62Long-term depression_Homo sapiens_hsa047300.92702052
63GABAergic synapse_Homo sapiens_hsa047270.92667600
64Phototransduction_Homo sapiens_hsa047440.92405547
65Rheumatoid arthritis_Homo sapiens_hsa053230.91850166
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.91501741
67Calcium signaling pathway_Homo sapiens_hsa040200.90091986
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89888933
69Staphylococcus aureus infection_Homo sapiens_hsa051500.89698260
70Hedgehog signaling pathway_Homo sapiens_hsa043400.89453411
71Melanogenesis_Homo sapiens_hsa049160.88582591
72Basal transcription factors_Homo sapiens_hsa030220.87971206
73Huntingtons disease_Homo sapiens_hsa050160.82942044
74Fatty acid biosynthesis_Homo sapiens_hsa000610.82925320
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81016885
76Oxytocin signaling pathway_Homo sapiens_hsa049210.80639988
77Glycerolipid metabolism_Homo sapiens_hsa005610.79801908
78Steroid biosynthesis_Homo sapiens_hsa001000.79120977
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.78796122
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78400641
81Oxidative phosphorylation_Homo sapiens_hsa001900.77951650
82Peroxisome_Homo sapiens_hsa041460.76350167
83beta-Alanine metabolism_Homo sapiens_hsa004100.75348202
84Ras signaling pathway_Homo sapiens_hsa040140.75096315
85Dopaminergic synapse_Homo sapiens_hsa047280.74554985
86Cocaine addiction_Homo sapiens_hsa050300.74518860
87Mineral absorption_Homo sapiens_hsa049780.74345389
88Adherens junction_Homo sapiens_hsa045200.74070460
89Taste transduction_Homo sapiens_hsa047420.73887265
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69997061
91Morphine addiction_Homo sapiens_hsa050320.66450811
92Bladder cancer_Homo sapiens_hsa052190.65372056
93Hepatitis C_Homo sapiens_hsa051600.64132114
94Insulin secretion_Homo sapiens_hsa049110.63828961
95Phagosome_Homo sapiens_hsa041450.63588615
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63459820
97Rap1 signaling pathway_Homo sapiens_hsa040150.61989667
98Bile secretion_Homo sapiens_hsa049760.61713741
99Propanoate metabolism_Homo sapiens_hsa006400.61436536
100Cholinergic synapse_Homo sapiens_hsa047250.60578583
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.59770667
102Fanconi anemia pathway_Homo sapiens_hsa034600.58604002
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57387992
104Fat digestion and absorption_Homo sapiens_hsa049750.57074130
105cAMP signaling pathway_Homo sapiens_hsa040240.55913820
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55901475
107Parkinsons disease_Homo sapiens_hsa050120.55405705
108Platelet activation_Homo sapiens_hsa046110.53881900
109Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53726055
110Dorso-ventral axis formation_Homo sapiens_hsa043200.52348478
111Fatty acid degradation_Homo sapiens_hsa000710.52112957
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51969947
113Estrogen signaling pathway_Homo sapiens_hsa049150.51510016
114Regulation of autophagy_Homo sapiens_hsa041400.51424226
115Gap junction_Homo sapiens_hsa045400.50662475
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49974479
117Arginine and proline metabolism_Homo sapiens_hsa003300.49001265
118Cardiac muscle contraction_Homo sapiens_hsa042600.47293847
119Alzheimers disease_Homo sapiens_hsa050100.47006214
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46261591
121Proteoglycans in cancer_Homo sapiens_hsa052050.43028551
122Type II diabetes mellitus_Homo sapiens_hsa049300.41696572
123Pertussis_Homo sapiens_hsa051330.41022137
124Basal cell carcinoma_Homo sapiens_hsa052170.40979461
125Salmonella infection_Homo sapiens_hsa051320.40879255
126Arginine biosynthesis_Homo sapiens_hsa002200.40740694
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40363687
128Fatty acid metabolism_Homo sapiens_hsa012120.40050257
129Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38979978
130PPAR signaling pathway_Homo sapiens_hsa033200.38165158
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38083170
132Melanoma_Homo sapiens_hsa052180.38006497
133Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37763587
134Purine metabolism_Homo sapiens_hsa002300.37647554
135Dilated cardiomyopathy_Homo sapiens_hsa054140.36757665
136Wnt signaling pathway_Homo sapiens_hsa043100.36718215
137Asthma_Homo sapiens_hsa053100.36470143
138Hippo signaling pathway_Homo sapiens_hsa043900.36235671
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34146616
140Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.33959209
141Ovarian steroidogenesis_Homo sapiens_hsa049130.33750739
142Circadian rhythm_Homo sapiens_hsa047100.33436510
143Glioma_Homo sapiens_hsa052140.32858867
144MAPK signaling pathway_Homo sapiens_hsa040100.32733878
145Primary bile acid biosynthesis_Homo sapiens_hsa001200.30815535

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