ADGRF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1RNA destabilization (GO:0050779)5.82217649
2piRNA metabolic process (GO:0034587)5.61590576
3sperm motility (GO:0030317)5.28397289
4DNA deamination (GO:0045006)5.26512772
5purine nucleobase biosynthetic process (GO:0009113)5.25737017
6artery smooth muscle contraction (GO:0014824)5.16392147
7secretory granule organization (GO:0033363)5.02944432
8folic acid-containing compound biosynthetic process (GO:0009396)4.91471330
9fat-soluble vitamin biosynthetic process (GO:0042362)4.84305098
10cilium or flagellum-dependent cell motility (GO:0001539)4.64184666
113-UTR-mediated mRNA stabilization (GO:0070935)4.62586740
12axonemal dynein complex assembly (GO:0070286)4.60274821
13activation of MAPKKK activity (GO:0000185)4.59778764
14spermatid development (GO:0007286)4.58674096
15regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)4.58015193
16positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO4.58015193
17response to gravity (GO:0009629)4.57565531
18fusion of sperm to egg plasma membrane (GO:0007342)4.57062248
19sperm-egg recognition (GO:0035036)4.52739560
20seminiferous tubule development (GO:0072520)4.52669177
21synaptonemal complex assembly (GO:0007130)4.41057356
22regulation of mRNA catabolic process (GO:0061013)4.32166444
23positive regulation of mRNA 3-end processing (GO:0031442)4.31322696
24regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)4.30674888
25positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)4.30674888
26tonic smooth muscle contraction (GO:0014820)4.29791619
27response to pheromone (GO:0019236)4.29337144
28male meiosis (GO:0007140)4.28438293
29acrosome reaction (GO:0007340)4.25582494
30definitive hemopoiesis (GO:0060216)4.24074641
31positive regulation of mRNA catabolic process (GO:0061014)4.23679772
32binding of sperm to zona pellucida (GO:0007339)4.23215380
33ribosome assembly (GO:0042255)4.22356320
34regulation of cilium movement (GO:0003352)4.16476389
35synaptonemal complex organization (GO:0070193)4.15120831
36guanosine-containing compound biosynthetic process (GO:1901070)4.09449672
37cell-cell recognition (GO:0009988)4.08043667
38maturation of SSU-rRNA (GO:0030490)4.07564003
39nucleobase biosynthetic process (GO:0046112)4.00794686
40retinal cone cell development (GO:0046549)3.93729081
41male meiosis I (GO:0007141)3.89100178
42multicellular organism reproduction (GO:0032504)3.86010012
43DNA catabolic process, exonucleolytic (GO:0000738)3.85939181
44DNA damage response, detection of DNA damage (GO:0042769)3.79068778
45meiosis I (GO:0007127)3.76101425
46cell wall macromolecule metabolic process (GO:0044036)3.73068687
47cell wall macromolecule catabolic process (GO:0016998)3.73068687
48acrosome assembly (GO:0001675)3.72678861
49plasma membrane fusion (GO:0045026)3.71010569
50DNA double-strand break processing (GO:0000729)3.67577176
51histone H2A monoubiquitination (GO:0035518)3.64363137
52regulation of mRNA 3-end processing (GO:0031440)3.63311101
53ribosome biogenesis (GO:0042254)3.61239249
54mitochondrial DNA replication (GO:0006264)3.61078577
55inner mitochondrial membrane organization (GO:0007007)3.50447784
56monoubiquitinated protein deubiquitination (GO:0035520)3.50065606
57vitamin transmembrane transport (GO:0035461)3.47512421
58regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.47274937
59tetrahydrofolate metabolic process (GO:0046653)3.46742235
60GTP biosynthetic process (GO:0006183)3.46470272
61negative regulation of transcription by competitive promoter binding (GO:0010944)3.45622351
62establishment of protein localization to mitochondrial membrane (GO:0090151)3.45249713
63vascular smooth muscle contraction (GO:0014829)3.42629641
64cell morphogenesis involved in neuron differentiation (GO:0048667)3.41805187
65folic acid-containing compound metabolic process (GO:0006760)3.41122786
66proteasome assembly (GO:0043248)3.40890120
67positive regulation of p38MAPK cascade (GO:1900745)3.40435139
68DNA methylation involved in gamete generation (GO:0043046)3.39781142
69UTP biosynthetic process (GO:0006228)3.38711899
70motile cilium assembly (GO:0044458)3.35021102
71meiotic chromosome segregation (GO:0045132)3.33421142
72antigen processing and presentation via MHC class Ib (GO:0002475)3.30880225
73protein prenylation (GO:0018342)3.28707512
74prenylation (GO:0097354)3.28707512
75chromatin remodeling at centromere (GO:0031055)3.24714381
76DNA ligation (GO:0006266)3.23323494
77ribosomal small subunit assembly (GO:0000028)3.22419850
78meiotic nuclear division (GO:0007126)3.21839278
79reciprocal DNA recombination (GO:0035825)3.19471219
80reciprocal meiotic recombination (GO:0007131)3.19471219
81cilium movement (GO:0003341)3.17911221
82pteridine-containing compound biosynthetic process (GO:0042559)3.16134186
83alditol metabolic process (GO:0019400)3.14909036
84indolalkylamine metabolic process (GO:0006586)3.13890368
85reproduction (GO:0000003)3.13360704
86CENP-A containing nucleosome assembly (GO:0034080)3.12814169
87regulation of spindle organization (GO:0090224)3.10451060
88negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.09608668
89carnitine metabolic process (GO:0009437)3.08813074
90epithelial cilium movement (GO:0003351)3.07904568
91negative regulation of complement activation (GO:0045916)3.06294737
92protein complex biogenesis (GO:0070271)3.04919464
93folic acid metabolic process (GO:0046655)3.04573509
94regulation of gene silencing by RNA (GO:0060966)3.03359642
95regulation of posttranscriptional gene silencing (GO:0060147)3.03359642
96regulation of gene silencing by miRNA (GO:0060964)3.03359642
97post-embryonic morphogenesis (GO:0009886)3.00831403
98resolution of meiotic recombination intermediates (GO:0000712)3.00643244
99positive regulation of prostaglandin secretion (GO:0032308)2.99257125
100replication fork processing (GO:0031297)2.98879088
101interferon-gamma secretion (GO:0072643)2.96487174
102tryptophan metabolic process (GO:0006568)2.96346198
103regulation of spindle checkpoint (GO:0090231)2.96188250
104organic cation transport (GO:0015695)2.93709135
105alkaloid metabolic process (GO:0009820)2.93638293
106mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.93168506
107mitochondrial respiratory chain complex assembly (GO:0033108)2.92596983
108DNA-dependent DNA replication (GO:0006261)2.90846533
109UTP metabolic process (GO:0046051)2.90743109
110fucose catabolic process (GO:0019317)2.90553898
111L-fucose metabolic process (GO:0042354)2.90553898
112L-fucose catabolic process (GO:0042355)2.90553898
113pseudouridine synthesis (GO:0001522)2.89068398
114amino-acid betaine metabolic process (GO:0006577)2.88336786
115regulation of sarcomere organization (GO:0060297)2.87453355
116GDP-mannose metabolic process (GO:0019673)2.86402053
117oxygen transport (GO:0015671)2.86314111
118endosome to pigment granule transport (GO:0043485)2.84568984
119endosome to melanosome transport (GO:0035646)2.84568984
120regulation of norepinephrine secretion (GO:0014061)2.84544881
121somatic hypermutation of immunoglobulin genes (GO:0016446)2.82209396
122somatic diversification of immune receptors via somatic mutation (GO:0002566)2.82209396
123chromosome organization involved in meiosis (GO:0070192)2.80234225
124mitochondrial respiratory chain complex I assembly (GO:0032981)2.80214501
125NADH dehydrogenase complex assembly (GO:0010257)2.80214501
126mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.80214501
127positive regulation of mRNA metabolic process (GO:1903313)2.79051299
128histone H3-K9 methylation (GO:0051567)2.78991450
129fertilization (GO:0009566)2.77440443
130membrane disassembly (GO:0030397)2.77349014
131nuclear envelope disassembly (GO:0051081)2.77349014
132sleep (GO:0030431)2.76664875
133intestinal cholesterol absorption (GO:0030299)2.76578766
134ribonucleoprotein complex biogenesis (GO:0022613)2.75896921
135oocyte maturation (GO:0001556)2.74894749
136mitotic nuclear envelope disassembly (GO:0007077)2.73893558
137pteridine-containing compound metabolic process (GO:0042558)2.73401107
138adenosine metabolic process (GO:0046085)2.72861204
139histone exchange (GO:0043486)2.72817232
140nucleoside diphosphate phosphorylation (GO:0006165)2.72663625
141epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.72134795
142GMP metabolic process (GO:0046037)2.71572138
143histone-serine phosphorylation (GO:0035404)2.70950667
144protein complex localization (GO:0031503)2.70093752
145negative regulation of protein activation cascade (GO:2000258)2.70068831
146regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.69857932
147negative regulation of inclusion body assembly (GO:0090084)2.68831841
148water-soluble vitamin biosynthetic process (GO:0042364)2.68260242
149male gamete generation (GO:0048232)2.67229122
150spermatogenesis (GO:0007283)2.66510846
151histamine secretion (GO:0001821)2.66379213
152regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.65653182
153L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.65544507
154signal peptide processing (GO:0006465)2.65537019
155negative regulation of norepinephrine secretion (GO:0010700)2.65490954
156negative regulation of protein oligomerization (GO:0032460)2.65170933
157phosphatidylethanolamine biosynthetic process (GO:0006646)2.64984651
158regulation of meiosis I (GO:0060631)2.64840839
159negative regulation of epidermal cell differentiation (GO:0045605)2.64093352
160synapsis (GO:0007129)2.64088165
161endoderm formation (GO:0001706)2.63630337
162negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.62334247
163N-acetylneuraminate metabolic process (GO:0006054)2.62287853
164recombinational repair (GO:0000725)2.61921258
165rRNA modification (GO:0000154)2.61421013
166antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.60789522
167establishment of protein localization to Golgi (GO:0072600)2.60506618
168cellular ketone body metabolic process (GO:0046950)2.60495758
169meiotic cell cycle process (GO:1903046)2.57939978
170purinergic nucleotide receptor signaling pathway (GO:0035590)2.56562022
171double-strand break repair via homologous recombination (GO:0000724)2.56369766
172regulation of collateral sprouting (GO:0048670)2.56101928
173regulation of nuclear cell cycle DNA replication (GO:0033262)2.54815434
174protein targeting to Golgi (GO:0000042)2.54686816
175positive regulation of macroautophagy (GO:0016239)2.53200200
176negative regulation of humoral immune response (GO:0002921)2.52507401
177lysine metabolic process (GO:0006553)2.52436156
178lysine catabolic process (GO:0006554)2.52436156
179viral mRNA export from host cell nucleus (GO:0046784)2.52085482
180mismatch repair (GO:0006298)2.51561887
181removal of superoxide radicals (GO:0019430)2.51264819
182cellular response to superoxide (GO:0071451)2.51264819
183cellular response to oxygen radical (GO:0071450)2.51264819
184tyrosine metabolic process (GO:0006570)2.51252504
185positive regulation of developmental pigmentation (GO:0048087)2.49349062
186centriole replication (GO:0007099)2.49005755
187retrograde transport, vesicle recycling within Golgi (GO:0000301)2.47782376
188regulation of prostaglandin secretion (GO:0032306)2.47757792
189phosphatidylethanolamine metabolic process (GO:0046337)2.47379940
190positive regulation of fatty acid transport (GO:2000193)2.47179983
191spliceosomal complex assembly (GO:0000245)2.46539104
192platelet dense granule organization (GO:0060155)11.2018270
193thrombin receptor signaling pathway (GO:0070493)10.1268356

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.76442080
2ZNF263_19887448_ChIP-Seq_K562_Human6.30310431
3EGR1_19374776_ChIP-ChIP_THP-1_Human5.59127475
4E2F7_22180533_ChIP-Seq_HELA_Human5.20729314
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.83468653
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.21412240
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.90442130
8NOTCH1_21737748_ChIP-Seq_TLL_Human3.16175500
9SCL_19346495_ChIP-Seq_HPC-7_Human3.03062181
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.89826950
11IGF1R_20145208_ChIP-Seq_DFB_Human2.72293443
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.61498929
13VDR_22108803_ChIP-Seq_LS180_Human2.55700096
14POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.46037956
15TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.46037956
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.45882624
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.30602007
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.30277820
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.26345127
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.23910566
21ELK1_19687146_ChIP-ChIP_HELA_Human2.21586900
22FUS_26573619_Chip-Seq_HEK293_Human2.18260852
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13520120
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.10691200
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.09140543
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.06195849
27CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05603911
28EWS_26573619_Chip-Seq_HEK293_Human2.02977332
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.02698830
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.01757505
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.97887133
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96655270
33MYC_18940864_ChIP-ChIP_HL60_Human1.95826355
34ZNF274_21170338_ChIP-Seq_K562_Hela1.94159532
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92387958
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.90144627
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.87427084
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.84955571
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81471515
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77347371
41HIF1A_21447827_ChIP-Seq_MCF-7_Human1.73718323
42IRF8_21731497_ChIP-ChIP_J774_Mouse1.73040187
43MYC_19030024_ChIP-ChIP_MESCs_Mouse1.70303742
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.69880716
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63736661
46SOX2_16153702_ChIP-ChIP_HESCs_Human1.63478035
47P300_19829295_ChIP-Seq_ESCs_Human1.61019342
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.59938079
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.59573190
50BCAT_22108803_ChIP-Seq_LS180_Human1.59207642
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59067160
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57889116
53VDR_23849224_ChIP-Seq_CD4+_Human1.55746753
54DCP1A_22483619_ChIP-Seq_HELA_Human1.54010688
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.51065966
56ETS1_20019798_ChIP-Seq_JURKAT_Human1.49989621
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49849985
58DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.49806181
59EGR1_23403033_ChIP-Seq_LIVER_Mouse1.48928815
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47745994
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46902758
62XRN2_22483619_ChIP-Seq_HELA_Human1.45572540
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.44848378
64TAF15_26573619_Chip-Seq_HEK293_Human1.43929271
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.41657386
66MYC_22102868_ChIP-Seq_BL_Human1.39670394
67ER_23166858_ChIP-Seq_MCF-7_Human1.36280623
68NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.36233311
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35804033
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35599866
71IRF1_19129219_ChIP-ChIP_H3396_Human1.34734570
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34661988
73JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.34307071
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33983126
75MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33623387
76AR_21909140_ChIP-Seq_LNCAP_Human1.32196547
77E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30291327
78MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.29751719
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29344228
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28446158
81IRF8_22096565_ChIP-ChIP_GC-B_Human1.27041584
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26434021
83FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26334230
84ESR2_21235772_ChIP-Seq_MCF-7_Human1.24278320
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.24078465
86TCF4_22108803_ChIP-Seq_LS180_Human1.23929602
87YY1_21170310_ChIP-Seq_MESCs_Mouse1.23063081
88KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22528724
89STAT3_23295773_ChIP-Seq_U87_Human1.20763520
90EST1_17652178_ChIP-ChIP_JURKAT_Human1.18840939
91FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.18518795
92NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15025718
93NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14964637
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14942471
95AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12902513
96HTT_18923047_ChIP-ChIP_STHdh_Human1.10328461
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10069830
98POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09741483
99GABP_17652178_ChIP-ChIP_JURKAT_Human1.09046351
100TCF4_23295773_ChIP-Seq_U87_Human1.08496567
101SRF_21415370_ChIP-Seq_HL-1_Mouse1.08043821
102SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.08042126
103FOXP3_21729870_ChIP-Seq_TREG_Human1.07431991
104RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07015741
105MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05826088
106CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04103699
107SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03869540
108P300_27268052_Chip-Seq_Bcells_Human1.03805141
109TCF7_22412390_ChIP-Seq_EML_Mouse1.03049659
110MYB_26560356_Chip-Seq_TH1_Human1.02142804
111NCOR1_26117541_ChIP-Seq_K562_Human1.01688236
112GBX2_23144817_ChIP-Seq_PC3_Human1.01157678
113SALL4_22934838_ChIP-ChIP_CD34+_Human0.99579441
114FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99493130
115AR_25329375_ChIP-Seq_VCAP_Human0.99177549
116PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98066677
117HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97639816
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96767215
119RUNX1_22412390_ChIP-Seq_EML_Mouse0.96234760
120IRF8_27001747_Chip-Seq_BMDM_Mouse0.96202950
121NANOG_19829295_ChIP-Seq_ESCs_Human0.95834807
122SOX2_19829295_ChIP-Seq_ESCs_Human0.95834807
123LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94942137
124SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94686585
125ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94444011
126POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94115119
127SMAD4_21799915_ChIP-Seq_A2780_Human0.93722958
128NANOG_16153702_ChIP-ChIP_HESCs_Human0.93678466
129CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93387963
130BCOR_27268052_Chip-Seq_Bcells_Human0.93296451
131RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93042292
132SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92967990
133NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92714238
134CDX2_22108803_ChIP-Seq_LS180_Human0.92613413
135SPI1_23547873_ChIP-Seq_NB4_Human0.92549901
136KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92116981
137IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.91693843
138PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90666039
139GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89832936
140FOXA1_25329375_ChIP-Seq_VCAP_Human0.89758256
141FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89758256
142UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89580070
143RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89557687
144TP63_19390658_ChIP-ChIP_HaCaT_Human0.89040813
145MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88680093
146E2F1_20622854_ChIP-Seq_HELA_Human0.88245421
147TTF2_22483619_ChIP-Seq_HELA_Human0.88210173
148SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87773542
149CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87247364
150BRD4_27068464_Chip-Seq_AML-cells_Mouse0.86989153
151KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.86525113
152KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.86525113
153KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.86525113
154P300_18555785_Chip-Seq_ESCs_Mouse0.85562439
155E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.85397781
156TP53_22573176_ChIP-Seq_HFKS_Human0.85173218
157E2F1_21310950_ChIP-Seq_MCF-7_Human0.85151000
158EZH2_27294783_Chip-Seq_NPCs_Mouse0.85005395
159CTCF_26484167_Chip-Seq_Bcells_Mouse0.84720845
160YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84709214
161TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83992508
162MYCN_18555785_ChIP-Seq_MESCs_Mouse0.83824718
163SMRT_27268052_Chip-Seq_Bcells_Human0.83452836
164TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.83390471
165RUNX2_22187159_ChIP-Seq_PCA_Human0.83151075
166MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.82831201
167RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.82818304
168E2F1_18555785_ChIP-Seq_MESCs_Mouse0.82607754
169TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82390677
170RUNX_20019798_ChIP-Seq_JUKART_Human0.81825382
171PU.1_20513432_ChIP-Seq_Bcells_Mouse0.81240001
172SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.80679855
173EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.79680580
174GATA1_26923725_Chip-Seq_HPCs_Mouse0.79593181
175HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.79476225

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.00308895
2MP0008057_abnormal_DNA_replication5.43885416
3MP0003195_calcinosis4.74178547
4MP0002638_abnormal_pupillary_reflex4.03888632
5MP0003136_yellow_coat_color3.85686738
6MP0002396_abnormal_hematopoietic_system3.77462477
7MP0001853_heart_inflammation3.29580404
8MP0008877_abnormal_DNA_methylation3.06076526
9MP0003011_delayed_dark_adaptation3.05507978
10MP0006072_abnormal_retinal_apoptosis3.02188759
11MP0008995_early_reproductive_senescence3.02029010
12MP0002254_reproductive_system_inflammat2.95120483
13MP0005171_absent_coat_pigmentation2.95112499
14MP0000383_abnormal_hair_follicle2.69060996
15MP0005174_abnormal_tail_pigmentation2.67009226
16MP0010094_abnormal_chromosome_stability2.55279678
17MP0000569_abnormal_digit_pigmentation2.53850929
18MP0004043_abnormal_pH_regulation2.50796204
19MP0003693_abnormal_embryo_hatching2.45281740
20MP0003786_premature_aging2.43927188
21MP0005253_abnormal_eye_physiology2.41433482
22MP0000372_irregular_coat_pigmentation2.31716637
23MP0001929_abnormal_gametogenesis2.30298618
24MP0003718_maternal_effect2.24492808
25MP0003698_abnormal_male_reproductive2.20988689
26MP0000579_abnormal_nail_morphology2.14498125
27MP0005670_abnormal_white_adipose2.07774624
28MP0003436_decreased_susceptibility_to1.95076316
29MP0008058_abnormal_DNA_repair1.92900617
30MP0005551_abnormal_eye_electrophysiolog1.92385916
31MP0005377_hearing/vestibular/ear_phenot1.88544008
32MP0003878_abnormal_ear_physiology1.88544008
33MP0005397_hematopoietic_system_phenotyp1.88264494
34MP0001545_abnormal_hematopoietic_system1.88264494
35MP0004947_skin_inflammation1.86181578
36MP0004808_abnormal_hematopoietic_stem1.82782083
37MP0000566_synostosis1.77396948
38MP0003879_abnormal_hair_cell1.72761515
39MP0002210_abnormal_sex_determination1.70859095
40MP0009840_abnormal_foam_cell1.68307444
41MP0010678_abnormal_skin_adnexa1.67328507
42MP0002452_abnormal_antigen_presenting1.63216993
43MP0005464_abnormal_platelet_physiology1.59609053
44MP0005671_abnormal_response_to1.58329256
45MP0002138_abnormal_hepatobiliary_system1.55567172
46MP0000689_abnormal_spleen_morphology1.55166487
47MP0001501_abnormal_sleep_pattern1.54100128
48MP0003111_abnormal_nucleus_morphology1.51879280
49MP0003077_abnormal_cell_cycle1.51736246
50MP0001145_abnormal_male_reproductive1.51059878
51MP0001764_abnormal_homeostasis1.50132045
52MP0001800_abnormal_humoral_immune1.49693381
53MP0003567_abnormal_fetal_cardiomyocyte1.47846940
54MP0002095_abnormal_skin_pigmentation1.47586329
55MP0010386_abnormal_urinary_bladder1.47075944
56MP0002398_abnormal_bone_marrow1.44517994
57MP0002722_abnormal_immune_system1.43838657
58MP0000015_abnormal_ear_pigmentation1.41805882
59MP0008007_abnormal_cellular_replicative1.41564164
60MP0005000_abnormal_immune_tolerance1.41520303
61MP0003448_altered_tumor_morphology1.41495219
62MP0002723_abnormal_immune_serum1.41015865
63MP0002419_abnormal_innate_immunity1.38658277
64MP0001873_stomach_inflammation1.37013933
65MP0002009_preneoplasia1.36163090
66MP0004957_abnormal_blastocyst_morpholog1.35835357
67MP0002166_altered_tumor_susceptibility1.35237771
68MP0010307_abnormal_tumor_latency1.33691534
69MP0002161_abnormal_fertility/fecundity1.31427170
70MP0002420_abnormal_adaptive_immunity1.28937293
71MP0001819_abnormal_immune_cell1.28932144
72MP0000653_abnormal_sex_gland1.26885716
73MP0005076_abnormal_cell_differentiation1.26638149
74MP0001542_abnormal_bone_strength1.24073520
75MP0000465_gastrointestinal_hemorrhage1.22961307
76MP0000703_abnormal_thymus_morphology1.21609469
77MP0001835_abnormal_antigen_presentation1.20628236
78MP0001293_anophthalmia1.16822250
79MP0000716_abnormal_immune_system1.15443027
80MP0005365_abnormal_bile_salt1.14539909
81MP0001851_eye_inflammation1.13052901
82MP0005025_abnormal_response_to1.12648135
83MP0002653_abnormal_ependyma_morphology1.11520980
84MP0010329_abnormal_lipoprotein_level1.11321041
85MP0006292_abnormal_olfactory_placode1.10688672
86MP0005391_vision/eye_phenotype1.09896604
87MP0009046_muscle_twitch1.08779823
88MP0002429_abnormal_blood_cell1.08464090
89MP0010155_abnormal_intestine_physiology1.01665711
90MP0009333_abnormal_splenocyte_physiolog1.01240094
91MP0000490_abnormal_crypts_of1.00363234
92MP0002006_tumorigenesis0.99901226
93MP0005379_endocrine/exocrine_gland_phen0.99271382
94MP0005645_abnormal_hypothalamus_physiol0.98157578
95MP0002019_abnormal_tumor_incidence0.98070139
96MP0006276_abnormal_autonomic_nervous0.96466793
97MP0004742_abnormal_vestibular_system0.95677206
98MP0004133_heterotaxia0.95115732
99MP0002933_joint_inflammation0.93523374
100MP0002139_abnormal_hepatobiliary_system0.91389515
101MP0002938_white_spotting0.90360214
102MP0002098_abnormal_vibrissa_morphology0.90359233
103MP0005085_abnormal_gallbladder_physiolo0.89341864
104MP0001533_abnormal_skeleton_physiology0.89058375
105MP0009697_abnormal_copulation0.87732230
106MP0003724_increased_susceptibility_to0.85725437
107MP0005310_abnormal_salivary_gland0.85609544
108MP0003828_pulmonary_edema0.85074900
109MP0005083_abnormal_biliary_tract0.84578533
110MP0000350_abnormal_cell_proliferation0.84085325
111MP0002132_abnormal_respiratory_system0.83762064
112MP0001529_abnormal_vocalization0.83438239
113MP0001790_abnormal_immune_system0.83123259
114MP0005387_immune_system_phenotype0.83123259
115MP0002163_abnormal_gland_morphology0.82882024
116MP0010352_gastrointestinal_tract_polyps0.82638470
117MP0000647_abnormal_sebaceous_gland0.81926460
118MP0002405_respiratory_system_inflammati0.80421097
119MP0003806_abnormal_nucleotide_metabolis0.80031365
120MP0001845_abnormal_inflammatory_respons0.79925025
121MP0003303_peritoneal_inflammation0.79902790
122MP0002148_abnormal_hypersensitivity_rea0.76882727
123MP0000631_abnormal_neuroendocrine_gland0.76481337
124MP0000013_abnormal_adipose_tissue0.74990656
125MP0001661_extended_life_span0.74330686
126MP0002127_abnormal_cardiovascular_syste0.74279636
127MP0008872_abnormal_physiological_respon0.73324735
128MP0002693_abnormal_pancreas_physiology0.72645033
129MP0000249_abnormal_blood_vessel0.72539457
130MP0005220_abnormal_exocrine_pancreas0.72404723
131MP0009785_altered_susceptibility_to0.72263410
132MP0003122_maternal_imprinting0.72065997
133MP0005636_abnormal_mineral_homeostasis0.71731326
134MP0003763_abnormal_thymus_physiology0.71503374
135MP0000427_abnormal_hair_cycle0.70825346
136MP0001765_abnormal_ion_homeostasis0.70035205
137MP0000858_altered_metastatic_potential0.69884858
138MP0005058_abnormal_lysosome_morphology0.69668047
139MP0008789_abnormal_olfactory_epithelium0.68847956
140MP0005332_abnormal_amino_acid0.68582102
141MP0003866_abnormal_defecation0.68486059
142MP0003252_abnormal_bile_duct0.67842977
143MP0005075_abnormal_melanosome_morpholog0.65976580
144MP0009379_abnormal_foot_pigmentation0.65829048
145MP0008469_abnormal_protein_level0.65825845
146MP0001963_abnormal_hearing_physiology0.63337531
147MP0005451_abnormal_body_composition0.63173556
148MP0005319_abnormal_enzyme/_coenzyme0.62793835
149MP0009278_abnormal_bone_marrow0.62564341
150MP0001756_abnormal_urination0.62534673
151MP0004883_abnormal_blood_vessel0.61734568
152MP0000371_diluted_coat_color0.61591576
153MP0009703_decreased_birth_body0.61364257
154MP0001485_abnormal_pinna_reflex0.61354364
155MP0008932_abnormal_embryonic_tissue0.61139535
156MP0000613_abnormal_salivary_gland0.60267018
157MP0000049_abnormal_middle_ear0.59167129
158MP0003941_abnormal_skin_development0.58107413
159MP0004019_abnormal_vitamin_homeostasis0.57418029
160MP0002837_dystrophic_cardiac_calcinosis0.55952100
161MP0000230_abnormal_systemic_arterial0.55791440

Predicted human phenotypes

RankGene SetZ-score
1Progressive muscle weakness (HP:0003323)6.38005440
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.56781897
3Abnormal spermatogenesis (HP:0008669)4.49006094
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.37327881
5Absent/shortened dynein arms (HP:0200106)4.37327881
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.27334580
7Hyperglycinemia (HP:0002154)4.23991530
8Abnormal respiratory motile cilium morphology (HP:0005938)4.21587646
9Abnormal respiratory epithelium morphology (HP:0012253)4.21587646
10Congenital stationary night blindness (HP:0007642)4.15368766
11Impulsivity (HP:0100710)4.07775611
12Hyperglycinuria (HP:0003108)3.90503019
13Chromsome breakage (HP:0040012)3.89678293
14Petechiae (HP:0000967)3.69702487
15Osteolytic defects of the hand bones (HP:0009699)3.64418835
16Osteolytic defects of the phalanges of the hand (HP:0009771)3.64418835
17Coronal craniosynostosis (HP:0004440)3.61021753
18Thrombocytosis (HP:0001894)3.58782001
19Duplicated collecting system (HP:0000081)3.58293131
20Abnormal number of erythroid precursors (HP:0012131)3.54065256
21Chronic otitis media (HP:0000389)3.42000885
22Nasal polyposis (HP:0100582)3.41206308
23Bundle branch block (HP:0011710)3.31343893
24Hypothermia (HP:0002045)3.24944645
25Abnormality of cells of the erythroid lineage (HP:0012130)3.20886686
26Abnormality of the renal collecting system (HP:0004742)3.17565512
27Chronic bronchitis (HP:0004469)3.16468122
28Breast hypoplasia (HP:0003187)3.13858857
29Pancreatic cysts (HP:0001737)3.12665275
30Infertility (HP:0000789)3.12359134
31Reticulocytopenia (HP:0001896)3.10933227
32Abnormality of glycine metabolism (HP:0010895)3.07496207
33Abnormality of serine family amino acid metabolism (HP:0010894)3.07496207
34Rhinitis (HP:0012384)3.07142571
35Congenital, generalized hypertrichosis (HP:0004540)3.06497264
36Azoospermia (HP:0000027)3.05229003
37Atrioventricular block (HP:0001678)3.01882973
38Progressive external ophthalmoplegia (HP:0000590)3.00141021
39Scanning speech (HP:0002168)2.99650176
40Bronchitis (HP:0012387)2.98928325
41Pancreatic fibrosis (HP:0100732)2.98766913
42Pancytopenia (HP:0001876)2.98702478
43Elevated erythrocyte sedimentation rate (HP:0003565)2.98559008
44Persistence of primary teeth (HP:0006335)2.97781031
45Growth hormone excess (HP:0000845)2.95161943
46Abnormality of the nasal mucosa (HP:0000433)2.92959736
47Bile duct proliferation (HP:0001408)2.92879267
48Abnormal biliary tract physiology (HP:0012439)2.92879267
49Pendular nystagmus (HP:0012043)2.91766791
50Albinism (HP:0001022)2.89010898
51Glucose intolerance (HP:0000833)2.87892055
52Recurrent bronchitis (HP:0002837)2.87235127
53True hermaphroditism (HP:0010459)2.86005129
54Pustule (HP:0200039)2.73904247
55Methylmalonic acidemia (HP:0002912)2.73715633
56Meckel diverticulum (HP:0002245)2.72880939
57Microvesicular hepatic steatosis (HP:0001414)2.72532026
58Methylmalonic aciduria (HP:0012120)2.70832668
59Ectopic kidney (HP:0000086)2.69635410
60Muscle fiber atrophy (HP:0100295)2.69413656
61Abnormal respiratory motile cilium physiology (HP:0012261)2.68701881
62Abnormality of chromosome stability (HP:0003220)2.63522821
63Large hands (HP:0001176)2.61102616
64Nephronophthisis (HP:0000090)2.60009204
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.59466311
66Supernumerary spleens (HP:0009799)2.59221892
67Abnormality of the ileum (HP:0001549)2.54342601
68Hypergonadotropic hypogonadism (HP:0000815)2.50956774
69Spinal muscular atrophy (HP:0007269)2.49934716
70Medial flaring of the eyebrow (HP:0010747)2.46152720
71Bony spicule pigmentary retinopathy (HP:0007737)2.45616815
72Decreased central vision (HP:0007663)2.42865234
73Abnormality of the renal medulla (HP:0100957)2.42585802
74Heart block (HP:0012722)2.42534593
75Conjunctival telangiectasia (HP:0000524)2.41755297
76Abnormality of the lower motor neuron (HP:0002366)2.39396039
77Abolished electroretinogram (ERG) (HP:0000550)2.37594121
78Birth length less than 3rd percentile (HP:0003561)2.36297072
79Postural instability (HP:0002172)2.35989694
80Abnormality of the preputium (HP:0100587)2.35595682
81Abnormal trabecular bone morphology (HP:0100671)2.35256062
82Diplopia (HP:0000651)2.35180425
83Abnormality of binocular vision (HP:0011514)2.35180425
84Bronchiectasis (HP:0002110)2.30519060
85Abnormality of vitamin B metabolism (HP:0004340)2.30260137
86Clubbing of toes (HP:0100760)2.29170320
87Male infertility (HP:0003251)2.28708552
88Abnormal atrioventricular conduction (HP:0005150)2.28150250
89Abnormality of the umbilical cord (HP:0010881)2.28032042
90Confusion (HP:0001289)2.25544173
91Hypoplasia of the thymus (HP:0000778)2.25494640
92Abnormality of the vasculature of the conjunctiva (HP:0008054)2.25422065
93Woolly hair (HP:0002224)2.23469429
94Gonadotropin excess (HP:0000837)2.23129721
95Hypochromic anemia (HP:0001931)2.21151349
96Rough bone trabeculation (HP:0100670)2.16607427
97Absent thumb (HP:0009777)2.15772926
98Type 2 muscle fiber atrophy (HP:0003554)2.13466323
99Attenuation of retinal blood vessels (HP:0007843)2.13062394
100Abnormal rod and cone electroretinograms (HP:0008323)2.12343535
101Chronic sinusitis (HP:0011109)2.11311771
102Gaze-evoked nystagmus (HP:0000640)2.10165302
103Stomach cancer (HP:0012126)2.09178083
104Insulin resistance (HP:0000855)2.08885866
105Abnormality of DNA repair (HP:0003254)2.06448919
106Mitochondrial inheritance (HP:0001427)2.05516656
107Agammaglobulinemia (HP:0004432)2.05333873
108Gout (HP:0001997)2.05240356
109Carpal bone hypoplasia (HP:0001498)2.02865347
110Increased circulating renin level (HP:0000848)2.02819697
111Ureteral duplication (HP:0000073)2.00916887
112Premature loss of primary teeth (HP:0006323)2.00796020
113Polyuria (HP:0000103)2.00227922
114Stenosis of the external auditory canal (HP:0000402)2.00138006
115Hyperpituitarism (HP:0010514)1.97633877
116Myelodysplasia (HP:0002863)1.96928137
117Panhypogammaglobulinemia (HP:0003139)1.96902760
118Hemiparesis (HP:0001269)1.96750049
119Abnormal ciliary motility (HP:0012262)1.96620272
120Acute necrotizing encephalopathy (HP:0006965)1.96357496
121Horseshoe kidney (HP:0000085)1.95019406
122Congenital malformation of the right heart (HP:0011723)1.94596125
123Double outlet right ventricle (HP:0001719)1.94596125
124Abnormality of serum amino acid levels (HP:0003112)1.94104588
125Congenital hepatic fibrosis (HP:0002612)1.93403271
126Broad foot (HP:0001769)1.93015419
127Molar tooth sign on MRI (HP:0002419)1.92338574
128Abnormality of midbrain morphology (HP:0002418)1.92338574
129IgM deficiency (HP:0002850)1.91822219
130Intestinal atresia (HP:0011100)1.91775410
131Delayed epiphyseal ossification (HP:0002663)1.91661045
132Aplasia/Hypoplasia of the patella (HP:0006498)1.90530623
133Increased CSF lactate (HP:0002490)1.88092936
134Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.87917164
135Recurrent otitis media (HP:0000403)1.87807739
136Pili torti (HP:0003777)1.87623125
137Abnormality of the carotid arteries (HP:0005344)1.87584129
138Congenital primary aphakia (HP:0007707)1.87447471
139Hypomagnesemia (HP:0002917)1.87353415
140Neonatal respiratory distress (HP:0002643)1.87056726
141Myoglobinuria (HP:0002913)1.86793154
142Microcytic anemia (HP:0001935)1.86686643
143Reduced antithrombin III activity (HP:0001976)1.85889236
144Urethral obstruction (HP:0000796)1.85185304
145Patellar aplasia (HP:0006443)1.84912989
146Squamous cell carcinoma (HP:0002860)1.84137875
147Gait imbalance (HP:0002141)1.84106104
148Generalized myoclonic seizures (HP:0002123)1.83766041
149Cystic liver disease (HP:0006706)1.82531309
150Microretrognathia (HP:0000308)1.82035769
151Abnormality of the vitamin B12 metabolism (HP:0004341)1.81773732
152Abnormal mitochondria in muscle tissue (HP:0008316)1.81491376
153Short palpebral fissure (HP:0012745)1.80879576
154Hypokinesia (HP:0002375)1.80057866
155Abnormality of homocysteine metabolism (HP:0010919)1.79664365
156Homocystinuria (HP:0002156)1.79664365
157Absent radius (HP:0003974)1.79462560
158Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78960762
1593-Methylglutaconic aciduria (HP:0003535)1.78534809
160Difficulty climbing stairs (HP:0003551)1.77372932
161Abnormality of subcutaneous fat tissue (HP:0001001)1.77369464
162Acute encephalopathy (HP:0006846)1.76880839
163Absent frontal sinuses (HP:0002688)1.76189465
164Cellular immunodeficiency (HP:0005374)1.74637896
165Astigmatism (HP:0000483)1.74551183
166Recurrent abscess formation (HP:0002722)1.74381434
167Duplication of thumb phalanx (HP:0009942)1.74080591
168Pallor (HP:0000980)1.73644579
169Hypercholesterolemia (HP:0003124)1.73335067
170Neutropenia (HP:0001875)1.73168234
171Leukocytosis (HP:0001974)1.73009138
172Sloping forehead (HP:0000340)1.71948877
173Abnormal urine output (HP:0012590)1.71938115
174Anencephaly (HP:0002323)1.71546929
175Recurrent sinusitis (HP:0011108)1.70599583
176Bone marrow hypocellularity (HP:0005528)1.70270224
177Facial hemangioma (HP:0000329)1.69993895
178Male pseudohermaphroditism (HP:0000037)1.69857870
179Abnormal glucose tolerance (HP:0001952)1.69472784
180Abnormality of the duodenum (HP:0002246)1.69002231
181Glomerulopathy (HP:0100820)1.68747641
182Amelogenesis imperfecta (HP:0000705)1.68716787
183Degeneration of anterior horn cells (HP:0002398)1.68514861
184Abnormality of the anterior horn cell (HP:0006802)1.68514861
185Ventricular fibrillation (HP:0001663)1.68017812
186Patent foramen ovale (HP:0001655)1.67529492
187Recurrent bacterial skin infections (HP:0005406)1.66461905
188Widely patent fontanelles and sutures (HP:0004492)1.65707420

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIM25.54601711
2TESK25.48364731
3TIE14.92653137
4DYRK34.40777561
5CDC73.46088917
6WNK33.22840748
7MAP2K22.98802168
8LATS12.83536861
9NUAK12.83073960
10WEE12.73517548
11BUB12.62431046
12BLK2.60962609
13CAMKK22.55638968
14RIPK12.37037757
15FRK2.32478506
16TLK12.29532978
17TSSK62.12028010
18MST42.11150088
19PDK42.07910811
20PDK32.07910811
21IRAK32.02681925
22PLK41.97897154
23TAF11.97308294
24CAMK1D1.84964696
25PDK21.80165267
26MAP4K21.79635113
27MAPK41.72392132
28NEK21.68335378
29BRSK21.65179638
30TESK11.63594525
31VRK11.55795674
32EIF2AK21.54456654
33IKBKB1.48523809
34MAP4K11.35154276
35MAPK71.34240372
36FGFR21.33937037
37RAF11.32782064
38AKT31.30304656
39PAK21.29825113
40EIF2AK11.29424734
41ITK1.26713229
42TEC1.26067853
43MKNK11.25151127
44TAOK31.23312121
45CDK81.23206402
46GRK11.22836393
47IRAK11.21069733
48BRSK11.20199389
49OXSR11.14209813
50ZAK1.13848347
51NLK1.11281726
52MAP3K141.11263846
53BMPR1B1.10197370
54PIM11.06141761
55TNIK1.05757274
56CAMK1G1.04691592
57ADRBK21.02607750
58ICK1.01578907
59MAP3K61.00483124
60MAP2K30.99419848
61MAP3K90.97010899
62PLK30.94926261
63TXK0.93543485
64TTK0.87114443
65FGFR30.86154813
66PTK2B0.86139305
67ACVR1B0.83907655
68RPS6KA20.83863604
69BTK0.83731787
70TNK20.83542400
71IKBKE0.83118260
72TBK10.82667100
73MAP3K40.81991484
74MAPK150.81787034
75EEF2K0.81678025
76RPS6KA10.80641339
77BRD40.80545155
78STK160.78405918
79EPHA20.77927788
80RPS6KA60.75375758
81VRK20.74901766
82CDK70.74424497
83IRAK40.73142236
84SRPK10.72697825
85STK240.68705818
86RPS6KL10.67534114
87RPS6KC10.67534114
88STK38L0.65674878
89ZAP700.64529019
90PLK10.64344080
91KIT0.64232494
92DYRK20.63889056
93MKNK20.63036652
94MAP3K100.60506953
95CAMKK10.60162836
96SGK20.60080954
97DYRK1B0.59217855
98PAK40.58440005
99CDK120.58371056
100INSRR0.57999790
101NME10.56508493
102BCKDK0.55129507
103JAK30.54501887
104CHEK20.54111568
105FGFR10.53754363
106ABL20.53028379
107RPS6KA50.51303738
108ALK0.50838563
109RPS6KB20.50003789
110STK40.49828091
111PRKD30.49719309
112DAPK20.48299182
113STK100.48039907
114MAPKAPK20.47915065
115PNCK0.47798232
116CCNB10.47655616
117MAPK110.46493386
118FGR0.45785325
119EIF2AK30.45778926
120ATR0.45605715
121GSK3A0.45186751
122STK390.45005987
123CSNK1A1L0.44100547
124MAPKAPK30.42469272
125AURKB0.42226020
126CHUK0.42086378
127DYRK1A0.41580330
128BMX0.41134577
129BMPR20.40899715
130LYN0.40168583
131IRAK20.39451890
132CSNK2A20.39372829
133MTOR0.38189325
134CDK30.37769509
135PRKCG0.37067858
136ATM0.36724843
137CAMK40.36516243
138STK380.35749730
139FGFR40.34797128
140STK30.33735585
141CDK60.33517264
142CSNK2A10.32732997
143PRKAA20.32680528
144AURKA0.32552534
145MAPK30.31917745
146MAP2K10.31552498
147MAP3K10.30659365
148PIK3CG0.30143021
149NME20.29983504
150PLK20.29657004
151WNK40.29459379
152CDK20.29444248
153SYK0.27151120
154ABL10.26853857

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.07924464
2Non-homologous end-joining_Homo sapiens_hsa034503.72745607
3Proteasome_Homo sapiens_hsa030503.38803508
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.37852417
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.28828393
6RNA polymerase_Homo sapiens_hsa030202.64276474
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.42503120
8RNA transport_Homo sapiens_hsa030132.31950028
9Folate biosynthesis_Homo sapiens_hsa007902.20320071
10Systemic lupus erythematosus_Homo sapiens_hsa053222.19370231
11Pyrimidine metabolism_Homo sapiens_hsa002402.18116451
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.14388879
13DNA replication_Homo sapiens_hsa030302.12936903
14Cyanoamino acid metabolism_Homo sapiens_hsa004602.12629156
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.12104084
16Oxidative phosphorylation_Homo sapiens_hsa001902.04833027
17Cell cycle_Homo sapiens_hsa041101.99533299
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.97441820
19Ribosome_Homo sapiens_hsa030101.91517871
20Fructose and mannose metabolism_Homo sapiens_hsa000511.88326855
21Parkinsons disease_Homo sapiens_hsa050121.87101174
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.85369456
23Huntingtons disease_Homo sapiens_hsa050161.83826722
24Protein export_Homo sapiens_hsa030601.80122040
25Pentose phosphate pathway_Homo sapiens_hsa000301.76374978
26Phototransduction_Homo sapiens_hsa047441.73481198
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.69647368
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.69190462
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.66805637
30Glycerophospholipid metabolism_Homo sapiens_hsa005641.61432542
31Lysine degradation_Homo sapiens_hsa003101.58892724
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53696718
33Butanoate metabolism_Homo sapiens_hsa006501.53424863
34Homologous recombination_Homo sapiens_hsa034401.52376968
35Tryptophan metabolism_Homo sapiens_hsa003801.51411946
36Spliceosome_Homo sapiens_hsa030401.51399836
37Purine metabolism_Homo sapiens_hsa002301.49903563
38p53 signaling pathway_Homo sapiens_hsa041151.46755302
39Histidine metabolism_Homo sapiens_hsa003401.44909424
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43340658
41Leishmaniasis_Homo sapiens_hsa051401.41351648
42Pyruvate metabolism_Homo sapiens_hsa006201.36409596
43Epstein-Barr virus infection_Homo sapiens_hsa051691.29811279
44Fanconi anemia pathway_Homo sapiens_hsa034601.29782231
45Nitrogen metabolism_Homo sapiens_hsa009101.27338698
46Antigen processing and presentation_Homo sapiens_hsa046121.20221304
47Alcoholism_Homo sapiens_hsa050341.19603465
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18485209
49B cell receptor signaling pathway_Homo sapiens_hsa046621.18194420
50Mismatch repair_Homo sapiens_hsa034301.17775186
51ABC transporters_Homo sapiens_hsa020101.17530250
52Alzheimers disease_Homo sapiens_hsa050101.16942113
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12830513
54Galactose metabolism_Homo sapiens_hsa000521.10860819
55Herpes simplex infection_Homo sapiens_hsa051681.10144449
56Retinol metabolism_Homo sapiens_hsa008301.08384994
57RNA degradation_Homo sapiens_hsa030181.05834390
58Complement and coagulation cascades_Homo sapiens_hsa046101.04996123
59Base excision repair_Homo sapiens_hsa034101.01457477
60Rheumatoid arthritis_Homo sapiens_hsa053231.00745359
61Taste transduction_Homo sapiens_hsa047420.99753815
62Glycerolipid metabolism_Homo sapiens_hsa005610.95907626
63Chemical carcinogenesis_Homo sapiens_hsa052040.95110874
64One carbon pool by folate_Homo sapiens_hsa006700.90776023
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88228610
66Basal transcription factors_Homo sapiens_hsa030220.85302926
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.84591031
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83902393
69Glutathione metabolism_Homo sapiens_hsa004800.83836025
70Fatty acid biosynthesis_Homo sapiens_hsa000610.83045284
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.82793878
72Arachidonic acid metabolism_Homo sapiens_hsa005900.82355270
73Hedgehog signaling pathway_Homo sapiens_hsa043400.80572068
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78794163
75Nucleotide excision repair_Homo sapiens_hsa034200.78465772
76Peroxisome_Homo sapiens_hsa041460.78412881
77Legionellosis_Homo sapiens_hsa051340.78058214
78Propanoate metabolism_Homo sapiens_hsa006400.77037785
79Osteoclast differentiation_Homo sapiens_hsa043800.76680282
80Fatty acid degradation_Homo sapiens_hsa000710.76217074
81Apoptosis_Homo sapiens_hsa042100.75230712
82Caffeine metabolism_Homo sapiens_hsa002320.74335081
83Steroid biosynthesis_Homo sapiens_hsa001000.73692993
84Arginine and proline metabolism_Homo sapiens_hsa003300.73170090
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72662566
86Selenocompound metabolism_Homo sapiens_hsa004500.72583027
87Oocyte meiosis_Homo sapiens_hsa041140.72387492
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72314665
89Biosynthesis of amino acids_Homo sapiens_hsa012300.72098517
90HTLV-I infection_Homo sapiens_hsa051660.71201325
91Linoleic acid metabolism_Homo sapiens_hsa005910.69252013
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68808171
93Sulfur metabolism_Homo sapiens_hsa009200.68640147
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.66226386
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65414760
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65198052
97Carbon metabolism_Homo sapiens_hsa012000.64230914
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61880966
99Basal cell carcinoma_Homo sapiens_hsa052170.61804260
100Vitamin digestion and absorption_Homo sapiens_hsa049770.61051934
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60645742
102mRNA surveillance pathway_Homo sapiens_hsa030150.59454676
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58118437
104Primary immunodeficiency_Homo sapiens_hsa053400.56748695
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56003212
106Cysteine and methionine metabolism_Homo sapiens_hsa002700.55612156
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53937348
108Serotonergic synapse_Homo sapiens_hsa047260.51965839
109Fatty acid elongation_Homo sapiens_hsa000620.51506996
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51174052
111Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50536957
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49634273
113Olfactory transduction_Homo sapiens_hsa047400.49048685
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.45606820
115Circadian rhythm_Homo sapiens_hsa047100.45521952
116Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42705338
117TNF signaling pathway_Homo sapiens_hsa046680.42123063
118Bile secretion_Homo sapiens_hsa049760.41437118
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39531149
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39310805
121Hepatitis B_Homo sapiens_hsa051610.37844152
122Cardiac muscle contraction_Homo sapiens_hsa042600.36805208
123Bladder cancer_Homo sapiens_hsa052190.35923341
124Shigellosis_Homo sapiens_hsa051310.35472239
125Regulation of autophagy_Homo sapiens_hsa041400.35095001
126Ovarian steroidogenesis_Homo sapiens_hsa049130.34825974
127PPAR signaling pathway_Homo sapiens_hsa033200.34755694
128Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34158497
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.33690483
130Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32853340
131Hematopoietic cell lineage_Homo sapiens_hsa046400.31687236
132beta-Alanine metabolism_Homo sapiens_hsa004100.31565737
133Measles_Homo sapiens_hsa051620.31040074
134Platelet activation_Homo sapiens_hsa046110.31015545
135Metabolic pathways_Homo sapiens_hsa011000.30222560
136Viral carcinogenesis_Homo sapiens_hsa052030.30138618
137Pertussis_Homo sapiens_hsa051330.26177993
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.25905799
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25787265
140Staphylococcus aureus infection_Homo sapiens_hsa051500.25621915
141Renin-angiotensin system_Homo sapiens_hsa046140.22391578
142Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22108654
143HIF-1 signaling pathway_Homo sapiens_hsa040660.21059590
144Ether lipid metabolism_Homo sapiens_hsa005650.20761564
145FoxO signaling pathway_Homo sapiens_hsa040680.20718350
146African trypanosomiasis_Homo sapiens_hsa051430.20265982
147Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18048243

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