ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	primary amino compound metabolic process (GO:1901160)	4.99932073
2	imidazole-containing compound metabolic process (GO:0052803)	4.85560908
3	regulation of sarcomere organization (GO:0060297)	4.62461847
4	protein-chromophore linkage (GO:0018298)	4.60852587
5	tryptophan catabolic process (GO:0006569)	4.43944510
6	indole-containing compound catabolic process (GO:0042436)	4.43944510
7	indolalkylamine catabolic process (GO:0046218)	4.43944510
8	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.43542177
9	indolalkylamine metabolic process (GO:0006586)	4.42283731
10	negative regulation of systemic arterial blood pressure (GO:0003085)	4.39171609
11	cilium or flagellum-dependent cell motility (GO:0001539)	4.35715433
12	kynurenine metabolic process (GO:0070189)	4.34761664
13	NAD biosynthetic process (GO:0009435)	4.21065170
14	negative regulation of mast cell activation (GO:0033004)	4.09998293
15	regulation of hippo signaling (GO:0035330)	4.08255417
16	serotonin metabolic process (GO:0042428)	4.03318700
17	adenosine metabolic process (GO:0046085)	4.03296822
18	platelet dense granule organization (GO:0060155)	4.03233990
19	indole-containing compound metabolic process (GO:0042430)	4.00599519
20	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.92219579
21	signal peptide processing (GO:0006465)	3.86768175
22	tryptophan metabolic process (GO:0006568)	3.85502914
23	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	3.78696767
24	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.63832530
25	cellular biogenic amine biosynthetic process (GO:0042401)	3.55368226
26	reflex (GO:0060004)	3.53593644
27	retinal cone cell development (GO:0046549)	3.52944194
28	musculoskeletal movement (GO:0050881)	3.50821460
29	multicellular organismal movement (GO:0050879)	3.50821460
30	amine biosynthetic process (GO:0009309)	3.49013575
31	monoubiquitinated protein deubiquitination (GO:0035520)	3.45524066
32	behavioral response to nicotine (GO:0035095)	3.35844736
33	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.35295760
34	postsynaptic membrane organization (GO:0001941)	3.32823537
35	phasic smooth muscle contraction (GO:0014821)	3.31849627
36	positive regulation of endothelial cell differentiation (GO:0045603)	3.28428190
37	photoreceptor cell maintenance (GO:0045494)	3.20042586
38	cytokine biosynthetic process (GO:0042089)	3.16912713
39	pyridine nucleotide biosynthetic process (GO:0019363)	3.14019632
40	nicotinamide nucleotide biosynthetic process (GO:0019359)	3.14019632
41	amino acid salvage (GO:0043102)	3.11690220
42	L-methionine salvage (GO:0071267)	3.11690220
43	L-methionine biosynthetic process (GO:0071265)	3.11690220
44	endosome to melanosome transport (GO:0035646)	3.10843319
45	endosome to pigment granule transport (GO:0043485)	3.10843319
46	tachykinin receptor signaling pathway (GO:0007217)	3.10349287
47	positive regulation of vasculogenesis (GO:2001214)	3.06078548
48	detection of light stimulus involved in visual perception (GO:0050908)	3.01278033
49	detection of light stimulus involved in sensory perception (GO:0050962)	3.01278033
50	cellular response to sterol (GO:0036315)	2.98646293
51	sphingoid metabolic process (GO:0046519)	2.94948394
52	righting reflex (GO:0060013)	2.92249119
53	regulation of T cell tolerance induction (GO:0002664)	2.90733959
54	negative regulation of keratinocyte proliferation (GO:0010839)	2.89778564
55	neural tube formation (GO:0001841)	2.88824743
56	cellular ketone body metabolic process (GO:0046950)	2.83940867
57	benzene-containing compound metabolic process (GO:0042537)	2.83372363
58	protein localization to cilium (GO:0061512)	2.82516016
59	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.81891764
60	positive regulation of mast cell activation involved in immune response (GO:0033008)	2.81270797
61	positive regulation of mast cell degranulation (GO:0043306)	2.81270797
62	neuronal action potential (GO:0019228)	2.80058739
63	behavioral response to ethanol (GO:0048149)	2.79348524
64	cysteine metabolic process (GO:0006534)	2.78861471
65	regulation of sequestering of triglyceride (GO:0010889)	2.75794072
66	fucose catabolic process (GO:0019317)	2.74334995
67	L-fucose metabolic process (GO:0042354)	2.74334995
68	L-fucose catabolic process (GO:0042355)	2.74334995
69	aromatic amino acid family metabolic process (GO:0009072)	2.73816847
70	protein K48-linked deubiquitination (GO:0071108)	2.73405389
71	mitochondrial RNA metabolic process (GO:0000959)	2.71184608
72	regulation of vasculogenesis (GO:2001212)	2.70600970
73	regulation of endothelial cell differentiation (GO:0045601)	2.69365514
74	adaptation of signaling pathway (GO:0023058)	2.67068060
75	aromatic amino acid family catabolic process (GO:0009074)	2.66518989
76	retina vasculature morphogenesis in camera-type eye (GO:0061299)	2.64346350
77	methionine biosynthetic process (GO:0009086)	2.63818800
78	phosphatidylglycerol biosynthetic process (GO:0006655)	2.61688916
79	xenobiotic catabolic process (GO:0042178)	2.61629798
80	methionine metabolic process (GO:0006555)	2.61152448
81	cytokine metabolic process (GO:0042107)	2.61082287
82	tRNA methylation (GO:0030488)	2.60046614
83	sulfur amino acid biosynthetic process (GO:0000097)	2.59538598
84	G-protein coupled receptor internalization (GO:0002031)	2.58721954
85	autophagic vacuole fusion (GO:0000046)	2.57462191
86	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.57329989
87	response to misfolded protein (GO:0051788)	2.57149909
88	inner ear receptor stereocilium organization (GO:0060122)	2.56558475
89	auditory receptor cell stereocilium organization (GO:0060088)	2.55501331
90	cellular biogenic amine catabolic process (GO:0042402)	2.53510658
91	amine catabolic process (GO:0009310)	2.53510658
92	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.53171092
93	thyroid hormone metabolic process (GO:0042403)	2.52001182
94	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.51471427
95	phosphorelay signal transduction system (GO:0000160)	2.50154634
96	negative regulation of Rho protein signal transduction (GO:0035024)	2.49385370
97	sulfation (GO:0051923)	2.49142865
98	rhodopsin mediated signaling pathway (GO:0016056)	2.48163379
99	lipopolysaccharide biosynthetic process (GO:0009103)	2.48134771
100	arginine catabolic process (GO:0006527)	2.47903275

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	4.15544360
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.27323529
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.20432283
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.04886637
5	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.01310412
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.90921519
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.41281455
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.38606264
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.35776563
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.29331921
11	DROSHA_22980978_ChIP-Seq_HELA_Human	2.09596139
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.03809384
13	P300_19829295_ChIP-Seq_ESCs_Human	2.00682564
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.99831223
15	STAT3_23295773_ChIP-Seq_U87_Human	1.93841057
16	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.81597958
17	BCAT_22108803_ChIP-Seq_LS180_Human	1.80769038
18	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.78975807
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.76798683
20	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.72259272
21	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.68646984
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.67326335
23	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.66564421
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.63547031
25	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.58271054
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.57656333
27	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.57018095
28	TAF15_26573619_Chip-Seq_HEK293_Human	1.56563569
29	SOX2_19829295_ChIP-Seq_ESCs_Human	1.55952923
30	NANOG_19829295_ChIP-Seq_ESCs_Human	1.55952923
31	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.55947974
32	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.50243357
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.49328542
34	AR_21572438_ChIP-Seq_LNCaP_Human	1.49220419
35	TP53_22573176_ChIP-Seq_HFKS_Human	1.48523545
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.47597063
37	CBP_20019798_ChIP-Seq_JUKART_Human	1.44903490
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.44903490
39	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.44221873
40	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.43649678
41	TCF4_23295773_ChIP-Seq_U87_Human	1.41059800
42	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.40996663
43	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.40746877
44	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.38080991
45	CDX2_22108803_ChIP-Seq_LS180_Human	1.37587439
46	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.35961755
47	TCF4_22108803_ChIP-Seq_LS180_Human	1.32250258
48	RXR_22108803_ChIP-Seq_LS180_Human	1.31223533
49	TP53_16413492_ChIP-PET_HCT116_Human	1.31139618
50	FUS_26573619_Chip-Seq_HEK293_Human	1.29958225
51	RUNX2_22187159_ChIP-Seq_PCA_Human	1.29912589
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.24997911
53	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24734680
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.23910121
55	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.23639940
56	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23244171
57	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.22153145
58	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.21297737
59	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.21098457
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.21098457
61	CJUN_26792858_Chip-Seq_BT549_Human	1.20568532
62	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.20523919
63	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.19675048
64	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.17949090
65	AR_25329375_ChIP-Seq_VCAP_Human	1.16853539
66	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.14279865
67	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.14255225
68	KDM2B_26808549_Chip-Seq_REH_Human	1.13935442
69	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.13840503
70	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.13669272
71	EWS_26573619_Chip-Seq_HEK293_Human	1.13173244
72	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.13108108
73	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.12861840
74	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.12478216
75	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.11478036
76	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.10097686
77	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.09983503
78	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.09718358
79	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.09142159
80	EGR1_19032775_ChIP-ChIP_M12_Human	1.08250099
81	TP53_18474530_ChIP-ChIP_U2OS_Human	1.07990499
82	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.07339829
83	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.07271234
84	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.06672327
85	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.06568907
86	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.06275850
87	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.05637105
88	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05109365
89	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.05109365
90	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.04635870
91	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.04511382
92	AHR_22903824_ChIP-Seq_MCF-7_Human	1.02717987
93	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.02712708
94	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.02248922
95	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.01903090
96	P300_18555785_Chip-Seq_ESCs_Mouse	1.01374835
97	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.01310609
98	REST_21632747_ChIP-Seq_MESCs_Mouse	1.00970831
99	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.00807613
100	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.00333221

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.63385222
2	MP0001501_abnormal_sleep_pattern	3.53205555
3	MP0003950_abnormal_plasma_membrane	3.38400655
4	MP0003136_yellow_coat_color	3.21269264
5	MP0005167_abnormal_blood-brain_barrier	3.11168471
6	MP0002736_abnormal_nociception_after	2.84894384
7	MP0002735_abnormal_chemical_nociception	2.64304068
8	MP0005423_abnormal_somatic_nervous	2.62577619
9	MP0002653_abnormal_ependyma_morphology	2.50890923
10	MP0003183_abnormal_peptide_metabolism	2.49163042
11	MP0005551_abnormal_eye_electrophysiolog	2.46498117
12	MP0005171_absent_coat_pigmentation	2.32324905
13	MP0001968_abnormal_touch/_nociception	2.28250073
14	MP0006054_spinal_hemorrhage	2.27332934
15	MP0004147_increased_porphyrin_level	2.26984283
16	MP0005084_abnormal_gallbladder_morpholo	2.26073993
17	MP0003646_muscle_fatigue	2.21469419
18	MP0005083_abnormal_biliary_tract	2.17670607
19	MP0003806_abnormal_nucleotide_metabolis	2.16181995
20	MP0005670_abnormal_white_adipose	2.12381110
21	MP0010368_abnormal_lymphatic_system	2.04742992
22	MP0003880_abnormal_central_pattern	1.89224634
23	MP0004043_abnormal_pH_regulation	1.87632091
24	MP0005085_abnormal_gallbladder_physiolo	1.85793029
25	MP0006082_CNS_inflammation	1.80846042
26	MP0005646_abnormal_pituitary_gland	1.80636883
27	MP0008872_abnormal_physiological_respon	1.77399425
28	MP0008995_early_reproductive_senescence	1.66637828
29	MP0006276_abnormal_autonomic_nervous	1.63628754
30	MP0001485_abnormal_pinna_reflex	1.60265321
31	MP0009046_muscle_twitch	1.58834108
32	MP0002332_abnormal_exercise_endurance	1.56147039
33	MP0009745_abnormal_behavioral_response	1.54604001
34	MP0009278_abnormal_bone_marrow	1.53709952
35	MP0005360_urolithiasis	1.50506060
36	MP0003724_increased_susceptibility_to	1.47272268
37	MP0003252_abnormal_bile_duct	1.47020428
38	MP0003045_fibrosis	1.44489294
39	MP0002734_abnormal_mechanical_nocicepti	1.42774722
40	MP0001764_abnormal_homeostasis	1.41595052
41	MP0005253_abnormal_eye_physiology	1.39453246
42	MP0003943_abnormal_hepatobiliary_system	1.38391504
43	MP0002928_abnormal_bile_duct	1.36983742
44	MP0002733_abnormal_thermal_nociception	1.34833387
45	MP0005595_abnormal_vascular_smooth	1.34767044
46	MP0002572_abnormal_emotion/affect_behav	1.30748996
47	MP0003638_abnormal_response/metabolism_	1.29455297
48	MP0001970_abnormal_pain_threshold	1.20598147
49	MP0002138_abnormal_hepatobiliary_system	1.20023876
50	MP0009697_abnormal_copulation	1.19721345
51	MP0000230_abnormal_systemic_arterial	1.18106937
52	MP0003633_abnormal_nervous_system	1.13761288
53	MP0002638_abnormal_pupillary_reflex	1.12674589
54	MP0001486_abnormal_startle_reflex	1.10084540
55	MP0005410_abnormal_fertilization	1.07716846
56	MP0009764_decreased_sensitivity_to	1.06599530
57	MP0002938_white_spotting	1.04880436
58	MP0005377_hearing/vestibular/ear_phenot	1.04149351
59	MP0003878_abnormal_ear_physiology	1.04149351
60	MP0002148_abnormal_hypersensitivity_rea	0.99338220
61	MP0005266_abnormal_metabolism	0.98735722
62	MP0001986_abnormal_taste_sensitivity	0.94567602
63	MP0004142_abnormal_muscle_tone	0.93607146
64	MP0002168_other_aberrant_phenotype	0.92348209
65	MP0004085_abnormal_heartbeat	0.89888323
66	MP0008058_abnormal_DNA_repair	0.87853072
67	MP0002067_abnormal_sensory_capabilities	0.86668864
68	MP0002064_seizures	0.86456507
69	MP0004233_abnormal_muscle_weight	0.85429350
70	MP0000026_abnormal_inner_ear	0.85204677
71	MP0002272_abnormal_nervous_system	0.84588694
72	MP0002557_abnormal_social/conspecific_i	0.83527720
73	MP0004145_abnormal_muscle_electrophysio	0.83144734
74	MP0005174_abnormal_tail_pigmentation	0.82757619
75	MP0004133_heterotaxia	0.82556816
76	MP0005332_abnormal_amino_acid	0.81746788
77	MP0008961_abnormal_basal_metabolism	0.80119320
78	MP0000371_diluted_coat_color	0.79905853
79	MP0008004_abnormal_stomach_pH	0.78805516
80	MP0001984_abnormal_olfaction	0.78401752
81	MP0001664_abnormal_digestion	0.77469274
82	MP0010386_abnormal_urinary_bladder	0.76891501
83	MP0002184_abnormal_innervation	0.74432175
84	MP0000372_irregular_coat_pigmentation	0.74226605
85	MP0003718_maternal_effect	0.74029809
86	MP0003698_abnormal_male_reproductive	0.73084806
87	MP0003635_abnormal_synaptic_transmissio	0.72692205
88	MP0005376_homeostasis/metabolism_phenot	0.72487901
89	MP0000631_abnormal_neuroendocrine_gland	0.72265719
90	MP0001963_abnormal_hearing_physiology	0.71354599
91	MP0000465_gastrointestinal_hemorrhage	0.70814259
92	MP0003631_nervous_system_phenotype	0.70485615
93	MP0000249_abnormal_blood_vessel	0.70030303
94	MP0005395_other_phenotype	0.68926969
95	MP0005448_abnormal_energy_balance	0.68560313
96	MP0002229_neurodegeneration	0.67252269
97	MP0003879_abnormal_hair_cell	0.67056761
98	MP0005195_abnormal_posterior_eye	0.66762845
99	MP0004215_abnormal_myocardial_fiber	0.66209446
100	MP0004885_abnormal_endolymph	0.64817329

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of alanine metabolism (HP:0010916)	4.97849847
2	Hyperalaninemia (HP:0003348)	4.97849847
3	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.97849847
4	Attenuation of retinal blood vessels (HP:0007843)	4.94328424
5	Congenital sensorineural hearing impairment (HP:0008527)	4.60059468
6	Increased neuronal autofluorescent lipopigment (HP:0002074)	4.29248413
7	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	4.27947257
8	Pancreatic cysts (HP:0001737)	3.80246570
9	Abolished electroretinogram (ERG) (HP:0000550)	3.67631228
10	Increased cerebral lipofuscin (HP:0011813)	3.56788129
11	Genetic anticipation (HP:0003743)	3.43715758
12	Chronic hepatic failure (HP:0100626)	3.43540804
13	Congenital stationary night blindness (HP:0007642)	3.39548973
14	Increased corneal curvature (HP:0100692)	3.36578432
15	Keratoconus (HP:0000563)	3.36578432
16	Constricted visual fields (HP:0001133)	3.31712566
17	Molar tooth sign on MRI (HP:0002419)	3.20210276
18	Abnormality of midbrain morphology (HP:0002418)	3.20210276
19	Progressive cerebellar ataxia (HP:0002073)	3.10555198
20	Hyperventilation (HP:0002883)	3.08178925
21	Gaze-evoked nystagmus (HP:0000640)	3.01667676
22	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.00292180
23	Retinal dysplasia (HP:0007973)	2.98630185
24	Central scotoma (HP:0000603)	2.96709928
25	True hermaphroditism (HP:0010459)	2.92340156
26	Pancreatic fibrosis (HP:0100732)	2.88840237
27	Bony spicule pigmentary retinopathy (HP:0007737)	2.88582471
28	Abnormality of macular pigmentation (HP:0008002)	2.85153841
29	Facial diplegia (HP:0001349)	2.77270360
30	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.75531886
31	Abnormal protein N-linked glycosylation (HP:0012347)	2.75531886
32	Abnormal protein glycosylation (HP:0012346)	2.75531886
33	Abnormal glycosylation (HP:0012345)	2.75531886
34	Cerebellar dysplasia (HP:0007033)	2.75327359
35	Febrile seizures (HP:0002373)	2.63289919
36	Type I transferrin isoform profile (HP:0003642)	2.61532461
37	Cystic liver disease (HP:0006706)	2.55852288
38	Type 2 muscle fiber atrophy (HP:0003554)	2.55571944
39	Abnormality of binocular vision (HP:0011514)	2.50955048
40	Diplopia (HP:0000651)	2.50955048
41	Inability to walk (HP:0002540)	2.48407854
42	Clumsiness (HP:0002312)	2.46837909
43	Sclerocornea (HP:0000647)	2.42462717
44	Absent speech (HP:0001344)	2.41066653
45	Autoimmune thrombocytopenia (HP:0001973)	2.40606059
46	Portal hypertension (HP:0001409)	2.37214805
47	Type II lissencephaly (HP:0007260)	2.34960788
48	Nephronophthisis (HP:0000090)	2.34746574
49	Decreased central vision (HP:0007663)	2.34742857
50	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.33032606
51	Scotoma (HP:0000575)	2.32092651
52	Progressive inability to walk (HP:0002505)	2.29858146
53	Large for gestational age (HP:0001520)	2.27334329
54	Abnormality of the hepatic vasculature (HP:0006707)	2.23607473
55	Abnormality of the ischium (HP:0003174)	2.14003534
56	Hypoplastic ischia (HP:0003175)	2.12857278
57	Congenital hepatic fibrosis (HP:0002612)	2.09577441
58	Abnormality of the renal medulla (HP:0100957)	2.08581637
59	Areflexia of lower limbs (HP:0002522)	2.07876842
60	Ileus (HP:0002595)	2.07684764
61	Esophageal varix (HP:0002040)	2.05581071
62	Abnormality of the pons (HP:0007361)	2.04385318
63	Hemiparesis (HP:0001269)	2.03866198
64	Thyroid-stimulating hormone excess (HP:0002925)	2.03353137
65	Pendular nystagmus (HP:0012043)	2.03283835
66	Polydipsia (HP:0001959)	2.02878062
67	Abnormal drinking behavior (HP:0030082)	2.02878062
68	Birth length less than 3rd percentile (HP:0003561)	2.02236998
69	Proximal tubulopathy (HP:0000114)	2.02092483
70	Cone-rod dystrophy (HP:0000548)	1.99237118
71	Poikiloderma (HP:0001029)	1.98329461
72	Ketoacidosis (HP:0001993)	1.97210257
73	Tubular atrophy (HP:0000092)	1.94859254
74	Methylmalonic aciduria (HP:0012120)	1.94624327
75	Small hand (HP:0200055)	1.94410645
76	Muscle fiber atrophy (HP:0100295)	1.93752869
77	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.93676894
78	Generalized aminoaciduria (HP:0002909)	1.93465253
79	Hypoplasia of the pons (HP:0012110)	1.91195949
80	Failure to thrive in infancy (HP:0001531)	1.90560408
81	Choroideremia (HP:0001139)	1.90000409
82	Nephrogenic diabetes insipidus (HP:0009806)	1.87553204
83	Decreased circulating renin level (HP:0003351)	1.86682319
84	Abnormal biliary tract physiology (HP:0012439)	1.86052989
85	Bile duct proliferation (HP:0001408)	1.86052989
86	Photophobia (HP:0000613)	1.83534217
87	Intrahepatic cholestasis (HP:0001406)	1.83225634
88	Albinism (HP:0001022)	1.82416675
89	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.81589212
90	Severe visual impairment (HP:0001141)	1.81436910
91	Depressed nasal tip (HP:0000437)	1.80306582
92	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.79132184
93	Conjugated hyperbilirubinemia (HP:0002908)	1.78359520
94	Vacuolated lymphocytes (HP:0001922)	1.78256867
95	Type II diabetes mellitus (HP:0005978)	1.77201886
96	Hypoplasia of the iris (HP:0007676)	1.73634540
97	Abnormal ciliary motility (HP:0012262)	1.72956883
98	Opisthotonus (HP:0002179)	1.72519366
99	Chorioretinal atrophy (HP:0000533)	1.70888372
100	Conjunctival telangiectasia (HP:0000524)	1.70833299

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.12767788
2	TIE1	6.95503498
3	INSRR	3.52062679
4	ACVR1B	3.18753063
5	BMPR1B	2.98420258
6	TRIM28	2.90035736
7	CASK	2.67886904
8	TAOK3	2.66022194
9	ADRBK2	2.53250136
10	PIK3CG	2.43052829
11	GRK1	2.38163375
12	MUSK	2.12691712
13	LATS1	2.01360159
14	FER	1.91553115
15	STK38L	1.80777418
16	NUAK1	1.76720263
17	NTRK3	1.58063591
18	TGFBR1	1.50144825
19	PDK2	1.29939242
20	TNK2	1.23309224
21	TEC	1.22020555
22	MAPK13	1.20487318
23	ADRBK1	1.15831932
24	KDR	1.12467628
25	PKN1	1.12358087
26	STK39	1.12191734
27	PRKD3	1.11922061
28	CCNB1	1.11320554
29	PINK1	1.03498555
30	SIK3	1.02482021
31	MAP4K2	1.00822314
32	PRKCE	0.92367649
33	OXSR1	0.89915734
34	BCKDK	0.81775659
35	PTK2B	0.79422775
36	WNK4	0.78972257
37	FGR	0.73181264
38	STK38	0.64615772
39	CDK9	0.62433429
40	IRAK4	0.61920081
41	CAMK2A	0.59390628
42	PIK3CA	0.58923290
43	DAPK2	0.58763849
44	TNIK	0.57859233
45	MAP2K1	0.56682385
46	BMPR2	0.56035158
47	PRKD2	0.54788230
48	CDK8	0.54155377
49	SIK2	0.52168072
50	PRKCH	0.52104963
51	MKNK2	0.50512145
52	LIMK1	0.50492232
53	ZAP70	0.50227205
54	NEK6	0.49818650
55	MARK3	0.48713884
56	ARAF	0.48623738
57	MOS	0.46755534
58	EPHA4	0.46655097
59	ERBB4	0.45480580
60	FES	0.43789866
61	IKBKB	0.42916758
62	MAP3K9	0.41948531
63	IRAK1	0.40174747
64	MAPK15	0.39635547
65	ZAK	0.38320663
66	MAP3K13	0.38145508
67	STK3	0.37293960
68	OBSCN	0.35437885
69	MAP3K3	0.35383558
70	EIF2AK3	0.35066736
71	ICK	0.34227652
72	PRKCQ	0.32859082
73	EPHB2	0.31767968
74	NTRK2	0.31516408
75	PRKCG	0.31325593
76	MATK	0.29145958
77	INSR	0.29004666
78	NEK1	0.27085404
79	MAPKAPK3	0.26995579
80	BCR	0.26664625
81	MAPKAPK2	0.26057092
82	PBK	0.25520904
83	PRKCI	0.25493084
84	PRKACB	0.25265462
85	WNK3	0.24736849
86	ERBB3	0.24593707
87	CSNK1A1L	0.24365332
88	PRKCA	0.23551241
89	EGFR	0.22813301
90	MAP3K4	0.22647775
91	PIM2	0.22156531
92	PRKACA	0.22051928
93	CAMK1	0.20715888
94	GRK7	0.19750451
95	PRKG1	0.18574096
96	CDK19	0.18401784
97	DAPK1	0.18295017
98	CAMK2B	0.17163130
99	PRKAA2	0.17010366
100	TGFBR2	0.16678242

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nitrogen metabolism_Homo sapiens_hsa00910	3.25794650
2	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.09556694
3	Selenocompound metabolism_Homo sapiens_hsa00450	2.73183183
4	Histidine metabolism_Homo sapiens_hsa00340	2.61437880
5	ABC transporters_Homo sapiens_hsa02010	2.55880834
6	Butanoate metabolism_Homo sapiens_hsa00650	2.32568847
7	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.27051485
8	Phototransduction_Homo sapiens_hsa04744	2.22924996
9	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.16193664
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.14730264
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.13926355
12	Tryptophan metabolism_Homo sapiens_hsa00380	2.09700188
13	Linoleic acid metabolism_Homo sapiens_hsa00591	2.08863769
14	Taste transduction_Homo sapiens_hsa04742	2.08383113
15	Nicotine addiction_Homo sapiens_hsa05033	1.96277131
16	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.94085436
17	Morphine addiction_Homo sapiens_hsa05032	1.86248107
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.73802824
19	Basal transcription factors_Homo sapiens_hsa03022	1.72297014
20	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.72152111
21	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.64483329
22	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.63182054
23	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.57655499
24	Olfactory transduction_Homo sapiens_hsa04740	1.55452509
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.53925606
26	Homologous recombination_Homo sapiens_hsa03440	1.49726318
27	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.49036419
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.48522972
29	Sulfur relay system_Homo sapiens_hsa04122	1.46199970
30	Ether lipid metabolism_Homo sapiens_hsa00565	1.44967545
31	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.34468573
32	One carbon pool by folate_Homo sapiens_hsa00670	1.31149679
33	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.29022831
34	Propanoate metabolism_Homo sapiens_hsa00640	1.26574111
35	Glutamatergic synapse_Homo sapiens_hsa04724	1.25854719
36	GABAergic synapse_Homo sapiens_hsa04727	1.25842337
37	Chemical carcinogenesis_Homo sapiens_hsa05204	1.20850419
38	Other glycan degradation_Homo sapiens_hsa00511	1.19787107
39	Retinol metabolism_Homo sapiens_hsa00830	1.19424701
40	Circadian entrainment_Homo sapiens_hsa04713	1.18621113
41	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.16741993
42	Peroxisome_Homo sapiens_hsa04146	1.13215466
43	Calcium signaling pathway_Homo sapiens_hsa04020	1.06729724
44	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.05838276
45	Renin-angiotensin system_Homo sapiens_hsa04614	1.05658617
46	Fanconi anemia pathway_Homo sapiens_hsa03460	1.04861984
47	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.03618058
48	Mineral absorption_Homo sapiens_hsa04978	0.97142064
49	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.95689453
50	Serotonergic synapse_Homo sapiens_hsa04726	0.95615806
51	Salivary secretion_Homo sapiens_hsa04970	0.95451945
52	Sphingolipid metabolism_Homo sapiens_hsa00600	0.92650456
53	Glycerolipid metabolism_Homo sapiens_hsa00561	0.90720222
54	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.88142944
55	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.85990249
56	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.83409797
57	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.79736899
58	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.76805809
59	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.76791207
60	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.73883164
61	Glutathione metabolism_Homo sapiens_hsa00480	0.72953904
62	Asthma_Homo sapiens_hsa05310	0.71372327
63	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.71135679
64	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.70723248
65	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.69035131
66	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.67302719
67	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.66172064
68	beta-Alanine metabolism_Homo sapiens_hsa00410	0.64912167
69	Collecting duct acid secretion_Homo sapiens_hsa04966	0.64387156
70	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.64104675
71	Gastric acid secretion_Homo sapiens_hsa04971	0.61400900
72	Rheumatoid arthritis_Homo sapiens_hsa05323	0.61140459
73	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.60851381
74	African trypanosomiasis_Homo sapiens_hsa05143	0.60424745
75	Legionellosis_Homo sapiens_hsa05134	0.59847391
76	Fatty acid degradation_Homo sapiens_hsa00071	0.57164059
77	Lysosome_Homo sapiens_hsa04142	0.56924211
78	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.56119038
79	Sulfur metabolism_Homo sapiens_hsa00920	0.55392279
80	Caffeine metabolism_Homo sapiens_hsa00232	0.51560144
81	Complement and coagulation cascades_Homo sapiens_hsa04610	0.50803112
82	Bile secretion_Homo sapiens_hsa04976	0.48670954
83	Purine metabolism_Homo sapiens_hsa00230	0.48405859
84	Fatty acid metabolism_Homo sapiens_hsa01212	0.48300288
85	Pancreatic secretion_Homo sapiens_hsa04972	0.47744923
86	Cholinergic synapse_Homo sapiens_hsa04725	0.47283955
87	cAMP signaling pathway_Homo sapiens_hsa04024	0.46079842
88	Metabolic pathways_Homo sapiens_hsa01100	0.45257534
89	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.42969941
90	Regulation of autophagy_Homo sapiens_hsa04140	0.41447825
91	PPAR signaling pathway_Homo sapiens_hsa03320	0.40324835
92	Fat digestion and absorption_Homo sapiens_hsa04975	0.39433254
93	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.38282088
94	Arginine and proline metabolism_Homo sapiens_hsa00330	0.37175164
95	Insulin secretion_Homo sapiens_hsa04911	0.37019051
96	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.34943400
97	TNF signaling pathway_Homo sapiens_hsa04668	0.34627653
98	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.31708565
99	Arginine biosynthesis_Homo sapiens_hsa00220	0.29815264
100	Ras signaling pathway_Homo sapiens_hsa04014	0.29339506

ADGRF5P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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