ADGRG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the G protein-coupled receptor family and regulates brain cortical patterning. The encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an inhibitor of tumor progression. Mutations in this gene are associated with a brain malformation known as bilateral frontoparietal polymicrogyria. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1definitive hemopoiesis (GO:0060216)8.14772666
2ribosomal small subunit assembly (GO:0000028)7.57841240
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)7.31019680
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.31019680
5negative regulation of erythrocyte differentiation (GO:0045647)6.58834952
6antigen processing and presentation via MHC class Ib (GO:0002475)6.11860795
7megakaryocyte development (GO:0035855)5.93090484
8antigen processing and presentation of endogenous antigen (GO:0019883)5.78311415
9platelet dense granule organization (GO:0060155)5.55089220
10viral transcription (GO:0019083)5.20619924
11postsynaptic membrane organization (GO:0001941)5.06254866
12positive regulation of B cell differentiation (GO:0045579)5.01160112
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.00186785
14translational termination (GO:0006415)4.94065925
15pyrimidine nucleobase catabolic process (GO:0006208)4.68663117
16lymphoid progenitor cell differentiation (GO:0002320)4.55906201
17translational elongation (GO:0006414)4.46535912
18secretory granule organization (GO:0033363)4.44970177
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.37829926
20endosome to pigment granule transport (GO:0043485)4.36243512
21endosome to melanosome transport (GO:0035646)4.36243512
22cotranslational protein targeting to membrane (GO:0006613)4.28305044
23protein targeting to ER (GO:0045047)4.24261178
24embryonic hemopoiesis (GO:0035162)4.23348032
25positive regulation of gamma-delta T cell activation (GO:0046645)4.22295215
26dendritic spine morphogenesis (GO:0060997)4.19691968
27regulation of erythrocyte differentiation (GO:0045646)4.14337651
28L-fucose catabolic process (GO:0042355)4.10162214
29fucose catabolic process (GO:0019317)4.10162214
30L-fucose metabolic process (GO:0042354)4.10162214
31central nervous system myelination (GO:0022010)4.06587448
32axon ensheathment in central nervous system (GO:0032291)4.06587448
33establishment of protein localization to endoplasmic reticulum (GO:0072599)4.05669658
34protein localization to endoplasmic reticulum (GO:0070972)4.02616099
35auditory behavior (GO:0031223)4.02095542
36presynaptic membrane organization (GO:0097090)4.01159754
37T cell homeostasis (GO:0043029)3.94056942
38nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.93745995
39Peyers patch development (GO:0048541)3.93359253
40mucosal-associated lymphoid tissue development (GO:0048537)3.93359253
41axonal fasciculation (GO:0007413)3.93000090
42presynaptic membrane assembly (GO:0097105)3.89983044
43heparin metabolic process (GO:0030202)3.89590020
44heparin biosynthetic process (GO:0030210)3.89590020
45DNA deamination (GO:0045006)3.87604361
46viral life cycle (GO:0019058)3.81989531
47nucleobase catabolic process (GO:0046113)3.80781438
48response to auditory stimulus (GO:0010996)3.80192846
49DNA unwinding involved in DNA replication (GO:0006268)3.79523279
50ribosomal small subunit biogenesis (GO:0042274)3.74487699
51dosage compensation (GO:0007549)3.70062700
52neuronal ion channel clustering (GO:0045161)3.64742638
53neuron recognition (GO:0008038)3.62779781
54regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.62086886
55cellular protein complex disassembly (GO:0043624)3.61416221
56neuron cell-cell adhesion (GO:0007158)3.59358315
57protein complex disassembly (GO:0043241)3.56044933
58protein-DNA complex disassembly (GO:0032986)3.54577646
59nucleosome disassembly (GO:0006337)3.54577646
60toxin transport (GO:1901998)3.53267907
61response to interferon-beta (GO:0035456)3.49301642
62establishment of mitochondrion localization (GO:0051654)3.47332670
63maturation of SSU-rRNA (GO:0030490)3.45425894
64regulation of gamma-delta T cell differentiation (GO:0045586)3.43163746
65locomotory exploration behavior (GO:0035641)3.43131117
66purine-containing compound salvage (GO:0043101)3.40186694
67mature B cell differentiation involved in immune response (GO:0002313)3.39093779
68lymph node development (GO:0048535)3.35069624
69cellular potassium ion homeostasis (GO:0030007)3.33955855
70peptidyl-tyrosine autophosphorylation (GO:0038083)3.33671619
71cellular response to thyroid hormone stimulus (GO:0097067)3.33339988
72astrocyte differentiation (GO:0048708)3.32838570
73regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.32279762
74sodium ion export (GO:0071436)3.31044472
75translational initiation (GO:0006413)3.29984069
76DNA strand elongation involved in DNA replication (GO:0006271)3.26925675
77macromolecular complex disassembly (GO:0032984)3.26782314
78synapse assembly (GO:0007416)3.26449929
79positive regulation of granulocyte differentiation (GO:0030854)3.26148363
803-UTR-mediated mRNA stabilization (GO:0070935)3.25687481
81regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.25085939
82response to interferon-alpha (GO:0035455)3.24489363
83mast cell activation (GO:0045576)3.21731286
84DNA strand elongation (GO:0022616)3.20413174
85mechanosensory behavior (GO:0007638)3.19781607
86telomere maintenance via semi-conservative replication (GO:0032201)3.17191870
87regulation of B cell differentiation (GO:0045577)3.15908965
88calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.15016995
89phospholipid scrambling (GO:0017121)3.14764740
90vocalization behavior (GO:0071625)3.14750443
91nuclear-transcribed mRNA catabolic process (GO:0000956)3.12272714
92cell migration in hindbrain (GO:0021535)3.10044106
93negative regulation of glycoprotein biosynthetic process (GO:0010561)3.08325486
94positive regulation of synapse assembly (GO:0051965)3.05370143
95deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.05027063
96ionotropic glutamate receptor signaling pathway (GO:0035235)3.04521448
97hemidesmosome assembly (GO:0031581)3.03936938
98regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.03390048
99regulation of gamma-delta T cell activation (GO:0046643)3.03110908
100mRNA catabolic process (GO:0006402)3.01811482
101mast cell degranulation (GO:0043303)3.01807410
102mast cell activation involved in immune response (GO:0002279)3.01807410
103myeloid cell development (GO:0061515)2.97661026
104thyroid hormone generation (GO:0006590)2.97227595
105fucosylation (GO:0036065)2.95646457
106negative regulation of oligodendrocyte differentiation (GO:0048715)2.93456797
107execution phase of apoptosis (GO:0097194)2.92997198
108germ cell migration (GO:0008354)2.90631771
109negative regulation of RNA splicing (GO:0033119)2.88511260
110negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.88338169
111regulation of synapse structural plasticity (GO:0051823)2.88310626
112camera-type eye morphogenesis (GO:0048593)2.87331499
113granulocyte differentiation (GO:0030851)2.87239024
114IMP biosynthetic process (GO:0006188)2.85433375
115negative regulation of stress fiber assembly (GO:0051497)2.85430059
116negative regulation of phagocytosis (GO:0050765)2.85103529
117leukocyte homeostasis (GO:0001776)2.84651721
118positive regulation of histone H3-K4 methylation (GO:0051571)2.84112009
119RNA catabolic process (GO:0006401)2.83996722
120positive regulation of erythrocyte differentiation (GO:0045648)2.83440587
121translesion synthesis (GO:0019985)2.83032883
122polyketide metabolic process (GO:0030638)2.82363522
123doxorubicin metabolic process (GO:0044598)2.82363522
124daunorubicin metabolic process (GO:0044597)2.82363522
125erythrocyte maturation (GO:0043249)2.81594776
126positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.80330161
127positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.79129101
128nonmotile primary cilium assembly (GO:0035058)2.78933457
129histamine transport (GO:0051608)2.78798573
130protein targeting to membrane (GO:0006612)2.78662812
131potassium ion import (GO:0010107)2.78080885
132regulation of histone H3-K4 methylation (GO:0051569)2.77940579
133regulation of glutamate receptor signaling pathway (GO:1900449)2.77840081
134membrane repolarization (GO:0086009)2.77771080
135exploration behavior (GO:0035640)2.77758870
136regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.77591053
137natural killer cell differentiation (GO:0001779)2.77232110
138IMP metabolic process (GO:0046040)2.76622759
139retinal ganglion cell axon guidance (GO:0031290)2.76276366
140positive regulation of protein deacetylation (GO:0090312)2.75834588
141dendritic spine organization (GO:0097061)2.74570021
142regulation of respiratory system process (GO:0044065)2.73290739
143Arp2/3 complex-mediated actin nucleation (GO:0034314)2.72876381
144neuronal stem cell maintenance (GO:0097150)2.71874184
145negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.71194122
146negative regulation of T-helper cell differentiation (GO:0045623)2.71194122
147axon extension (GO:0048675)2.70893505
148layer formation in cerebral cortex (GO:0021819)2.70670405
149substrate-independent telencephalic tangential migration (GO:0021826)2.69880630
150substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.69880630
151mitochondrion transport along microtubule (GO:0047497)2.69173427
152establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.69173427
153potassium ion homeostasis (GO:0055075)2.68560420
154positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.68290757
155membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.68289077
156negative regulation of catenin import into nucleus (GO:0035414)2.68268202
157dendrite morphogenesis (GO:0048813)2.66599835
158forebrain neuron differentiation (GO:0021879)2.65599974
159establishment of nucleus localization (GO:0040023)2.65321508
160oligodendrocyte differentiation (GO:0048709)2.65190884
161cerebellar granule cell differentiation (GO:0021707)2.64872990
162amino acid import (GO:0043090)2.64763707
163glutamate secretion (GO:0014047)2.64474124
164nephron tubule formation (GO:0072079)2.63440667
165synapse organization (GO:0050808)2.61038675
166positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.60444857
167dermatan sulfate biosynthetic process (GO:0030208)2.58218100
168L-amino acid import (GO:0043092)2.56799117
169negative regulation of axonogenesis (GO:0050771)2.56064800
170negative regulation of axon extension (GO:0030517)2.56018181
171spinal cord development (GO:0021510)2.53932613
172synaptic transmission, glutamatergic (GO:0035249)2.53770017
173regulation of axon extension involved in axon guidance (GO:0048841)2.53239355
174dermatan sulfate metabolic process (GO:0030205)2.51107279
175chondroitin sulfate catabolic process (GO:0030207)2.50868688
176central nervous system projection neuron axonogenesis (GO:0021952)2.50123157
177establishment of planar polarity (GO:0001736)2.46354851
178establishment of tissue polarity (GO:0007164)2.46354851
179synaptic vesicle exocytosis (GO:0016079)2.46135589
180adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.45513773
181behavioral response to nicotine (GO:0035095)2.43973900
182nephron tubule development (GO:0072080)2.43750827
183axon extension involved in axon guidance (GO:0048846)2.43706860
184neuron projection extension involved in neuron projection guidance (GO:1902284)2.43706860
185regulation of axonogenesis (GO:0050770)2.43390534
186synaptic vesicle maturation (GO:0016188)2.42732019
187cell-cell junction maintenance (GO:0045217)2.42648785
188neurotransmitter-gated ion channel clustering (GO:0072578)2.41678474
189cerebral cortex radially oriented cell migration (GO:0021799)2.41271792
190transmission of nerve impulse (GO:0019226)2.41268770
191eye photoreceptor cell differentiation (GO:0001754)2.41104983
192photoreceptor cell differentiation (GO:0046530)2.41104983
193synaptic vesicle endocytosis (GO:0048488)2.40363329
194neuron projection regeneration (GO:0031102)2.40089975
195gamma-aminobutyric acid transport (GO:0015812)2.39519624
196semaphorin-plexin signaling pathway (GO:0071526)2.38621047
197regulation of axon guidance (GO:1902667)2.38463629
198glial cell differentiation (GO:0010001)2.37841979
199positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.35255304
200regulation of neurotransmitter uptake (GO:0051580)2.34084734

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_19346495_ChIP-Seq_HPC-7_Human5.94478402
2EZH2_22144423_ChIP-Seq_EOC_Human5.39734059
3E2F7_22180533_ChIP-Seq_HELA_Human5.25018544
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.53976514
5RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.37521563
6MYC_22102868_ChIP-Seq_BL_Human3.33765027
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.29564193
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.27147112
9TAL1_20887958_ChIP-Seq_HPC-7_Mouse3.06682068
10VDR_21846776_ChIP-Seq_THP-1_Human2.92570754
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.91874368
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.85106089
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.84929569
14SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.73009205
15SUZ12_27294783_Chip-Seq_ESCs_Mouse2.68211268
16GATA1_22025678_ChIP-Seq_K562_Human2.64260498
17LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.58326428
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.53822093
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.51727771
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.49808086
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.47394405
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.43024392
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.39516812
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.32624598
25JARID2_20075857_ChIP-Seq_MESCs_Mouse2.31920046
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.31396089
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30883969
28CIITA_25753668_ChIP-Seq_RAJI_Human2.29904527
29SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.29009350
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26648570
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.25793048
32TCF7_22412390_ChIP-Seq_EML_Mouse2.25696743
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.25399181
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.22563954
35LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.21317456
36MYC_18555785_ChIP-Seq_MESCs_Mouse2.20348283
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.19342879
38EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17523066
39RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17523066
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15171630
41REST_21632747_ChIP-Seq_MESCs_Mouse2.14707865
42MYB_21317192_ChIP-Seq_ERMYB_Mouse2.14330574
43DROSHA_22980978_ChIP-Seq_HELA_Human2.12782444
44EED_16625203_ChIP-ChIP_MESCs_Mouse2.12476518
45VDR_24763502_ChIP-Seq_THP-1_Human2.11407343
46ERG_20887958_ChIP-Seq_HPC-7_Mouse2.11291653
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.09183089
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.08861998
49ERG_21242973_ChIP-ChIP_JURKAT_Human2.05981052
50MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05661558
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.03236551
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.02752204
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.01138569
54SPI1_23547873_ChIP-Seq_NB4_Human1.99688260
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.98693097
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98467035
57GATA1_22383799_ChIP-Seq_G1ME_Mouse1.98108606
58RUNX1_22412390_ChIP-Seq_EML_Mouse1.91437034
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.89915159
60SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.87526905
61MAF_26560356_Chip-Seq_TH1_Human1.84104600
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.83190104
63GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.82469032
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.80879087
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.80038121
66REST_18959480_ChIP-ChIP_MESCs_Mouse1.78674863
67GATA1_19941827_ChIP-Seq_MEL_Mouse1.75507594
68UTX_26944678_Chip-Seq_JUKART_Human1.75346052
69HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.74675349
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.73426504
71GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.73417177
72MYB_26560356_Chip-Seq_TH2_Human1.72960148
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.72085667
74RING1B_27294783_Chip-Seq_ESCs_Mouse1.68944819
75EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.63564474
76OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.60297218
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59280254
78BP1_19119308_ChIP-ChIP_Hs578T_Human1.58071493
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57514885
80ESR2_21235772_ChIP-Seq_MCF-7_Human1.55538437
81MYB_26560356_Chip-Seq_TH1_Human1.55317901
82FOXP3_21729870_ChIP-Seq_TREG_Human1.55302581
83KDM2B_26808549_Chip-Seq_K562_Human1.54882805
84E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.53619178
85MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53097186
86RARB_27405468_Chip-Seq_BRAIN_Mouse1.51123501
87GATA2_22383799_ChIP-Seq_G1ME_Mouse1.50890049
88TP53_20018659_ChIP-ChIP_R1E_Mouse1.50692924
89XRN2_22483619_ChIP-Seq_HELA_Human1.49433862
90ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48403324
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48216813
92TRIM28_21343339_ChIP-Seq_HEK293_Human1.48084024
93KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47363742
94NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47253467
95DNAJC2_21179169_ChIP-ChIP_NT2_Human1.45590296
96CTCF_27219007_Chip-Seq_Bcells_Human1.45055896
97SPI1_23127762_ChIP-Seq_K562_Human1.44495490
98SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.44091626
99RUNX_20019798_ChIP-Seq_JUKART_Human1.43896762
100CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.41444474
101FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.39916125
102STAT6_21828071_ChIP-Seq_BEAS2B_Human1.39682258
103ELK3_25401928_ChIP-Seq_HUVEC_Human1.35394222
104RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.34826862
105ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34177940
106STAT4_19710469_ChIP-ChIP_TH1__Mouse1.32916264
107NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32753639
108IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31523258
109MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29660963
110VDR_23849224_ChIP-Seq_CD4+_Human1.29487689
111RING1B_27294783_Chip-Seq_NPCs_Mouse1.28733169
112FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27110229
113GBX2_23144817_ChIP-Seq_PC3_Human1.26756565
114ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24431180
115GATA2_21666600_ChIP-Seq_HMVEC_Human1.23656111
116FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.22288896
117WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21792683
118MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21458834
119EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21177413
120BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20243302
121RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20157286
122KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20031851
123EST1_17652178_ChIP-ChIP_JURKAT_Human1.19484511
124RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19130312
125ETS1_22383799_ChIP-Seq_G1ME_Mouse1.18854099
126KDM2B_26808549_Chip-Seq_DND41_Human1.18482238
127TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17365861
128SMC4_20622854_ChIP-Seq_HELA_Human1.16829480
129GATA1_19941826_ChIP-Seq_K562_Human1.14668697
130SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13194052
131CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13109163
132SRF_21415370_ChIP-Seq_HL-1_Mouse1.10340898
133ETS1_20019798_ChIP-Seq_JURKAT_Human1.09364015
134TET1_21490601_ChIP-Seq_MESCs_Mouse1.09294937
135TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08852815
136KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08560647
137MAF_26560356_Chip-Seq_TH2_Human1.07358046
138E2F1_21310950_ChIP-Seq_MCF-7_Human1.07021047
139GABP_19822575_ChIP-Seq_HepG2_Human1.06453572
140FOXM1_23109430_ChIP-Seq_U2OS_Human1.06393905
141E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06387902
142VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05479841
143FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.04189321
144CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03613548
145AR_21572438_ChIP-Seq_LNCaP_Human1.03230750
146ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00698444
147NCOR1_26117541_ChIP-Seq_K562_Human1.00329672
148PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96771450
149E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96502310
150RNF2_27304074_Chip-Seq_NSC_Mouse0.96437433
151TTF2_22483619_ChIP-Seq_HELA_Human0.95157370
152CTCF_18555785_ChIP-Seq_MESCs_Mouse0.94687592
153TP63_22573176_ChIP-Seq_HFKS_Human0.94616301
154SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94114319
155CTCF_21964334_ChIP-Seq_BJAB-B_Human0.94044270
156JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.93801935
157PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93120760
158SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92920177
159BCL6_27268052_Chip-Seq_Bcells_Human0.92571527
160TP53_23651856_ChIP-Seq_MEFs_Mouse0.92536056
161WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92157075
162ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92059945
163NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.91611639
164FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91354557
165LXR_22292898_ChIP-Seq_THP-1_Human0.91177777
166NELFA_20434984_ChIP-Seq_ESCs_Mouse0.90999361
167AR_19668381_ChIP-Seq_PC3_Human0.90625961
168MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90382303
169ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89471266
170ELF1_20517297_ChIP-Seq_JURKAT_Human0.89289224
171NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89179832
172RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88951345
173THAP11_20581084_ChIP-Seq_MESCs_Mouse0.88918754
174UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86471861
175BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86331930
176SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86059871
177AHR_22903824_ChIP-Seq_MCF-7_Human0.85942575
178PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85729263
179ELK4_26923725_Chip-Seq_MESODERM_Mouse0.84605146
180P68_20966046_ChIP-Seq_HELA_Human0.84572070
181OCT4_19829295_ChIP-Seq_ESCs_Human0.84442271
182ARNT_22903824_ChIP-Seq_MCF-7_Human0.82859724
183CTBP2_25329375_ChIP-Seq_LNCAP_Human0.81518654
184SA1_27219007_Chip-Seq_ERYTHROID_Human0.81179462
185KDM2B_26808549_Chip-Seq_JURKAT_Human0.81153942
186RUNX1_27514584_Chip-Seq_MCF-7_Human0.80930827
187P53_22127205_ChIP-Seq_FIBROBLAST_Human0.80814789
188MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.78913793
189CTBP1_25329375_ChIP-Seq_LNCAP_Human0.78777885
190CREB1_26743006_Chip-Seq_LNCaP_Human0.77462041
191CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76819542
192RACK7_27058665_Chip-Seq_MCF-7_Human0.76705368
193ESR1_21235772_ChIP-Seq_MCF-7_Human0.76454149
194ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.75775833
195P63_26484246_Chip-Seq_KERATINOCYTES_Human0.74759496
196YAP1_20516196_ChIP-Seq_MESCs_Mouse0.74498864
197KLF4_19829295_ChIP-Seq_ESCs_Human0.74446208

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system5.27577013
2MP0004808_abnormal_hematopoietic_stem4.11649262
3MP0004859_abnormal_synaptic_plasticity3.70261158
4MP0000465_gastrointestinal_hemorrhage3.58113770
5MP0005423_abnormal_somatic_nervous3.45797484
6MP0005397_hematopoietic_system_phenotyp3.43242150
7MP0001545_abnormal_hematopoietic_system3.43242150
8MP0009278_abnormal_bone_marrow3.42668170
9MP0004147_increased_porphyrin_level3.22944414
10MP0005174_abnormal_tail_pigmentation3.15110471
11MP0005464_abnormal_platelet_physiology3.01321158
12MP0000579_abnormal_nail_morphology2.87306286
13MP0000778_abnormal_nervous_system2.85987581
14MP0003136_yellow_coat_color2.71180428
15MP0002653_abnormal_ependyma_morphology2.62879376
16MP0003880_abnormal_central_pattern2.55228566
17MP0005075_abnormal_melanosome_morpholog2.48177716
18MP0001835_abnormal_antigen_presentation2.45073626
19MP0004270_analgesia2.40629357
20MP0000685_abnormal_immune_system2.35939129
21MP0002822_catalepsy2.34665509
22MP0001986_abnormal_taste_sensitivity2.28118073
23MP0002095_abnormal_skin_pigmentation2.22417291
24MP0003724_increased_susceptibility_to2.21333703
25MP0003635_abnormal_synaptic_transmissio2.18751359
26MP0002398_abnormal_bone_marrow2.15804425
27MP0000566_synostosis2.15578092
28MP0005671_abnormal_response_to2.14056315
29MP0003866_abnormal_defecation2.13348042
30MP0000490_abnormal_crypts_of2.11782170
31MP0003300_gastrointestinal_ulcer2.11117499
32MP0002877_abnormal_melanocyte_morpholog2.07741806
33MP0006054_spinal_hemorrhage2.04387230
34MP0003329_amyloid_beta_deposits2.00325441
35MP0001502_abnormal_circadian_rhythm1.95791093
36MP0002063_abnormal_learning/memory/cond1.92484037
37MP0003763_abnormal_thymus_physiology1.92431474
38MP0003943_abnormal_hepatobiliary_system1.91441330
39MP0005394_taste/olfaction_phenotype1.89678542
40MP0005499_abnormal_olfactory_system1.89678542
41MP0002572_abnormal_emotion/affect_behav1.89283637
42MP0000689_abnormal_spleen_morphology1.83097684
43MP0001873_stomach_inflammation1.78874578
44MP0006276_abnormal_autonomic_nervous1.77796654
45MP0001984_abnormal_olfaction1.76284077
46MP0002722_abnormal_immune_system1.75956996
47MP0008007_abnormal_cellular_replicative1.74477995
48MP0000955_abnormal_spinal_cord1.71879712
49MP0001486_abnormal_startle_reflex1.70184374
50MP0005025_abnormal_response_to1.68329339
51MP0001853_heart_inflammation1.68040750
52MP0009785_altered_susceptibility_to1.67803697
53MP0002909_abnormal_adrenal_gland1.67769694
54MP0000716_abnormal_immune_system1.65365978
55MP0003283_abnormal_digestive_organ1.64948049
56MP0008789_abnormal_olfactory_epithelium1.64943462
57MP0002429_abnormal_blood_cell1.63296055
58MP0010368_abnormal_lymphatic_system1.62321314
59MP0002420_abnormal_adaptive_immunity1.62032145
60MP0002064_seizures1.60758570
61MP0003787_abnormal_imprinting1.59463427
62MP0001819_abnormal_immune_cell1.59197745
63MP0001529_abnormal_vocalization1.57759232
64MP0009745_abnormal_behavioral_response1.56896027
65MP0002638_abnormal_pupillary_reflex1.56459949
66MP0008569_lethality_at_weaning1.55724206
67MP0002734_abnormal_mechanical_nocicepti1.53305472
68MP0002272_abnormal_nervous_system1.52953087
69MP0002557_abnormal_social/conspecific_i1.52780514
70MP0010155_abnormal_intestine_physiology1.52586531
71MP0003122_maternal_imprinting1.52184156
72MP0004858_abnormal_nervous_system1.52048304
73MP0002166_altered_tumor_susceptibility1.51869507
74MP0002452_abnormal_antigen_presenting1.51630909
75MP0002882_abnormal_neuron_morphology1.50038056
76MP0000703_abnormal_thymus_morphology1.49075516
77MP0003011_delayed_dark_adaptation1.48953662
78MP0002723_abnormal_immune_serum1.48638880
79MP0005171_absent_coat_pigmentation1.45903371
80MP0001800_abnormal_humoral_immune1.44778243
81MP0003690_abnormal_glial_cell1.42951728
82MP0002184_abnormal_innervation1.42440504
83MP0000026_abnormal_inner_ear1.41571838
84MP0001905_abnormal_dopamine_level1.40245255
85MP0003634_abnormal_glial_cell1.38948307
86MP0001968_abnormal_touch/_nociception1.37363196
87MP0010094_abnormal_chromosome_stability1.36682609
88MP0004133_heterotaxia1.34689456
89MP0001485_abnormal_pinna_reflex1.32890546
90MP0001970_abnormal_pain_threshold1.31629677
91MP0008995_early_reproductive_senescence1.31266578
92MP0004381_abnormal_hair_follicle1.29898373
93MP0002419_abnormal_innate_immunity1.24952336
94MP0005409_darkened_coat_color1.24817757
95MP0003879_abnormal_hair_cell1.24809601
96MP0009379_abnormal_foot_pigmentation1.22814177
97MP0002152_abnormal_brain_morphology1.20385067
98MP0001879_abnormal_lymphatic_vessel1.20078079
99MP0005248_abnormal_Harderian_gland1.19253472
100MP0002733_abnormal_thermal_nociception1.18144165
101MP0008058_abnormal_DNA_repair1.17126698
102MP0004811_abnormal_neuron_physiology1.16556070
103MP0003172_abnormal_lysosome_physiology1.15434032
104MP0005000_abnormal_immune_tolerance1.15350876
105MP0002067_abnormal_sensory_capabilities1.15315682
106MP0002249_abnormal_larynx_morphology1.14617183
107MP0002735_abnormal_chemical_nociception1.14165193
108MP0000383_abnormal_hair_follicle1.13724947
109MP0002752_abnormal_somatic_nervous1.13635323
110MP0002019_abnormal_tumor_incidence1.12093490
111MP0003077_abnormal_cell_cycle1.10888733
112MP0003191_abnormal_cellular_cholesterol1.10189047
113MP0000762_abnormal_tongue_morphology1.09442014
114MP0002736_abnormal_nociception_after1.08155742
115MP0004742_abnormal_vestibular_system1.07996801
116MP0000462_abnormal_digestive_system1.06736944
117MP0002098_abnormal_vibrissa_morphology1.05583876
118MP0004924_abnormal_behavior1.02312077
119MP0005386_behavior/neurological_phenoty1.02312077
120MP0004142_abnormal_muscle_tone1.01601343
121MP0002876_abnormal_thyroid_physiology1.01141204
122MP0001963_abnormal_hearing_physiology1.00636098
123MP0000534_abnormal_ureter_morphology0.99376964
124MP0008961_abnormal_basal_metabolism0.98306916
125MP0000049_abnormal_middle_ear0.98178358
126MP0003183_abnormal_peptide_metabolism0.98133447
127MP0000313_abnormal_cell_death0.97602919
128MP0003436_decreased_susceptibility_to0.97331852
129MP0000631_abnormal_neuroendocrine_gland0.97061985
130MP0003638_abnormal_response/metabolism_0.96919148
131MP0003693_abnormal_embryo_hatching0.96663682
132MP0003828_pulmonary_edema0.96480787
133MP0001188_hyperpigmentation0.95005405
134MP0000920_abnormal_myelination0.94790863
135MP0005220_abnormal_exocrine_pancreas0.94018657
136MP0002148_abnormal_hypersensitivity_rea0.93890922
137MP0002229_neurodegeneration0.93680228
138MP0003861_abnormal_nervous_system0.92908468
139MP0002075_abnormal_coat/hair_pigmentati0.91508068
140MP0009046_muscle_twitch0.90515350
141MP0001845_abnormal_inflammatory_respons0.90070779
142MP0005551_abnormal_eye_electrophysiolog0.90045239
143MP0001440_abnormal_grooming_behavior0.89950223
144MP0002089_abnormal_postnatal_growth/wei0.89515093
145MP0005645_abnormal_hypothalamus_physiol0.88582103
146MP0005377_hearing/vestibular/ear_phenot0.88514935
147MP0003878_abnormal_ear_physiology0.88514935
148MP0009333_abnormal_splenocyte_physiolog0.88210530
149MP0003632_abnormal_nervous_system0.87870750
150MP0000377_abnormal_hair_follicle0.87324849
151MP0000343_altered_response_to0.87224623
152MP0005387_immune_system_phenotype0.87197318
153MP0001790_abnormal_immune_system0.87197318
154MP0003075_altered_response_to0.87189158
155MP0002066_abnormal_motor_capabilities/c0.87153988
156MP0003123_paternal_imprinting0.87086163
157MP0002405_respiratory_system_inflammati0.85668449
158MP0002006_tumorigenesis0.85282302
159MP0003938_abnormal_ear_development0.84610248
160MP0010678_abnormal_skin_adnexa0.84411766
161MP0000477_abnormal_intestine_morphology0.84059321
162MP0002938_white_spotting0.83787601
163MP0001851_eye_inflammation0.83586858
164MP0005253_abnormal_eye_physiology0.82651707
165MP0003868_abnormal_feces_composition0.82515751
166MP0000467_abnormal_esophagus_morphology0.81915733
167MP0009780_abnormal_chondrocyte_physiolo0.81370717
168MP0003656_abnormal_erythrocyte_physiolo0.81204218
169MP0003121_genomic_imprinting0.81198464
170MP0004947_skin_inflammation0.80316689
171MP0008469_abnormal_protein_level0.80108407
172MP0002069_abnormal_eating/drinking_beha0.79658611
173MP0000015_abnormal_ear_pigmentation0.79134758
174MP0006292_abnormal_olfactory_placode0.78149343
175MP0003755_abnormal_palate_morphology0.77720613
176MP0005195_abnormal_posterior_eye0.77266370
177MP0001663_abnormal_digestive_system0.75733206
178MP0010352_gastrointestinal_tract_polyps0.75057297
179MP0008057_abnormal_DNA_replication0.72987017
180MP0001270_distended_abdomen0.72557734
181MP0005167_abnormal_blood-brain_barrier0.70567543
182MP0006036_abnormal_mitochondrial_physio0.68592339
183MP0005058_abnormal_lysosome_morphology0.67903503
184MP0005646_abnormal_pituitary_gland0.67646752
185MP0000681_abnormal_thyroid_gland0.66143138
186MP0004885_abnormal_endolymph0.64953488
187MP0002928_abnormal_bile_duct0.64269839
188MP0004957_abnormal_blastocyst_morpholog0.63517665
189MP0001348_abnormal_lacrimal_gland0.63464313
190MP0001944_abnormal_pancreas_morphology0.62941286
191MP0003111_abnormal_nucleus_morphology0.62553724
192MP0003567_abnormal_fetal_cardiomyocyte0.61550840
193MP0001765_abnormal_ion_homeostasis0.60761804

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)5.87457137
2Chronic otitis media (HP:0000389)5.38906296
3Aplastic anemia (HP:0001915)5.33054312
4Prolonged bleeding time (HP:0003010)5.30268929
5Petechiae (HP:0000967)4.86958050
6IgM deficiency (HP:0002850)4.45926206
7Abnormality of cells of the erythroid lineage (HP:0012130)4.18455016
8Abnormal platelet function (HP:0011869)4.16997471
9Impaired platelet aggregation (HP:0003540)4.16997471
10Abnormal number of erythroid precursors (HP:0012131)4.08966400
11Myokymia (HP:0002411)3.78951307
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.71570980
13Epistaxis (HP:0000421)3.61455859
14Neurofibrillary tangles (HP:0002185)3.54463547
15Abnormality of the nasal mucosa (HP:0000433)3.48363438
16Abnormality of the heme biosynthetic pathway (HP:0010472)3.47384914
17Reticulocytopenia (HP:0001896)3.42174622
18Interstitial pulmonary disease (HP:0006530)3.40920316
19Acute lymphatic leukemia (HP:0006721)3.37486280
20Cellulitis (HP:0100658)3.25362661
21Acute myeloid leukemia (HP:0004808)3.19131193
22Panhypogammaglobulinemia (HP:0003139)3.15956860
23Polyphagia (HP:0002591)3.10193127
24Amaurosis fugax (HP:0100576)3.09294435
25Abnormality of T cell physiology (HP:0011840)3.04208600
26Elevated erythrocyte sedimentation rate (HP:0003565)3.02586104
27Myositis (HP:0100614)3.00129999
28Pili torti (HP:0003777)2.95007270
29Milia (HP:0001056)2.94051041
30Recurrent bronchitis (HP:0002837)2.91964694
31Hyperacusis (HP:0010780)2.86874554
32Fatigue (HP:0012378)2.83442430
33Nasal polyposis (HP:0100582)2.82959616
34Gastrointestinal inflammation (HP:0004386)2.82387980
35Fragile nails (HP:0001808)2.82203006
36Thyroid-stimulating hormone excess (HP:0002925)2.81766634
37Hemiparesis (HP:0001269)2.79624350
38Megalencephaly (HP:0001355)2.70529943
39Colon cancer (HP:0003003)2.69975919
40Spontaneous hematomas (HP:0007420)2.68993695
41Supranuclear gaze palsy (HP:0000605)2.68312977
42Abnormality of binocular vision (HP:0011514)2.67678397
43Diplopia (HP:0000651)2.67678397
44Purpura (HP:0000979)2.66337373
45Split foot (HP:0001839)2.65860584
46Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.58599220
47Myelodysplasia (HP:0002863)2.57866416
48Hyperthyroidism (HP:0000836)2.52386195
49Cerebral inclusion bodies (HP:0100314)2.52245107
50Agammaglobulinemia (HP:0004432)2.51312451
51Morphological abnormality of the inner ear (HP:0011390)2.51218192
5211 pairs of ribs (HP:0000878)2.49758579
53Inflammation of the large intestine (HP:0002037)2.49468483
54Recurrent viral infections (HP:0004429)2.49085997
55Pallor (HP:0000980)2.48191724
56Gingival bleeding (HP:0000225)2.47831525
57Hemiplegia (HP:0002301)2.47502045
58Muscle fiber atrophy (HP:0100295)2.45339304
59Abnormal eating behavior (HP:0100738)2.44560934
60Type 2 muscle fiber atrophy (HP:0003554)2.43272982
61Abnormality of nail color (HP:0100643)2.42805001
62Albinism (HP:0001022)2.42571729
63Poikiloderma (HP:0001029)2.42116446
64Increased neuronal autofluorescent lipopigment (HP:0002074)2.36084861
65Goiter (HP:0000853)2.34454355
66Type I transferrin isoform profile (HP:0003642)2.33073791
67Abnormality of the intervertebral disk (HP:0005108)2.32699609
68Abnormality of the fingertips (HP:0001211)2.29356205
69Anomalous pulmonary venous return (HP:0010772)2.27109768
70Erythema (HP:0010783)2.25554885
71Menorrhagia (HP:0000132)2.25062885
72Chronic sinusitis (HP:0011109)2.24848163
73Retinal dysplasia (HP:0007973)2.24538304
74Peripheral hypomyelination (HP:0007182)2.24082249
75Progressive cerebellar ataxia (HP:0002073)2.23367488
76Patchy hypopigmentation of hair (HP:0011365)2.21664452
77Chest pain (HP:0100749)2.21628704
78Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.19433213
79Abnormal protein N-linked glycosylation (HP:0012347)2.19433213
80Abnormal protein glycosylation (HP:0012346)2.19433213
81Abnormal glycosylation (HP:0012345)2.19433213
82Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.19219136
83Gait imbalance (HP:0002141)2.16091311
84Pancytopenia (HP:0001876)2.15552409
85Progressive neurologic deterioration (HP:0002344)2.14952402
86Gastrointestinal stroma tumor (HP:0100723)2.14454484
87Ankle clonus (HP:0011448)2.13855263
88Generalized aminoaciduria (HP:0002909)2.13847600
89Plantar hyperkeratosis (HP:0007556)2.13586363
90Macrocytic anemia (HP:0001972)2.11865577
91Bronchomalacia (HP:0002780)2.09989303
92Hematochezia (HP:0002573)2.09582292
93Oligodactyly (hands) (HP:0001180)2.09403137
94White forelock (HP:0002211)2.08428329
95Agitation (HP:0000713)2.07907183
96Increased cerebral lipofuscin (HP:0011813)2.07251330
97Abnormal respiratory motile cilium physiology (HP:0012261)2.07083349
98Focal motor seizures (HP:0011153)2.06946829
99Colitis (HP:0002583)2.06130404
100Sparse scalp hair (HP:0002209)2.03999732
101Arterial thrombosis (HP:0004420)2.03989801
102Obstructive sleep apnea (HP:0002870)2.03871938
103Onycholysis (HP:0001806)2.00016529
104Reduced antithrombin III activity (HP:0001976)1.99225121
105Broad face (HP:0000283)1.97489524
106Rib fusion (HP:0000902)1.97380231
107Abnormal respiratory motile cilium morphology (HP:0005938)1.97055426
108Abnormal respiratory epithelium morphology (HP:0012253)1.97055426
109Bruising susceptibility (HP:0000978)1.97010210
110Increased IgE level (HP:0003212)1.96965658
111Limb dystonia (HP:0002451)1.93907180
112Abnormality of T cells (HP:0002843)1.93262437
113Microcytic anemia (HP:0001935)1.93016807
114Abnormality of the corticospinal tract (HP:0002492)1.92957274
115Sleep apnea (HP:0010535)1.90975447
116Gonadotropin excess (HP:0000837)1.90689680
117Focal seizures (HP:0007359)1.90326877
118Meningitis (HP:0001287)1.89985701
119Renal dysplasia (HP:0000110)1.89013822
120Abnormal platelet volume (HP:0011876)1.89005379
121Cerebellar dysplasia (HP:0007033)1.88085744
122Intention tremor (HP:0002080)1.86836443
123Elfin facies (HP:0004428)1.85472570
124Hypoplasia of the corpus callosum (HP:0002079)1.85395109
125Atrophic scars (HP:0001075)1.85378387
126Laryngomalacia (HP:0001601)1.84950882
127Gonadal dysgenesis (HP:0000133)1.84764623
128Type II lissencephaly (HP:0007260)1.84231725
129Large hands (HP:0001176)1.84001246
130Growth hormone excess (HP:0000845)1.83852640
131Hypoplasia of the thymus (HP:0000778)1.82796470
132Oligodactyly (HP:0012165)1.82692018
133Papilledema (HP:0001085)1.82459292
134Heterochromia iridis (HP:0001100)1.79948067
135Hypsarrhythmia (HP:0002521)1.79803378
136Lymphopenia (HP:0001888)1.79436338
137Ulnar claw (HP:0001178)1.79106569
138Entropion (HP:0000621)1.78599368
139Asplenia (HP:0001746)1.78351366
140Lymphoma (HP:0002665)1.77560396
141Esophageal atresia (HP:0002032)1.77417877
142Meningocele (HP:0002435)1.77318114
143Neoplasm of head and neck (HP:0012288)1.76985629
144Esophageal neoplasm (HP:0100751)1.76985629
145Action tremor (HP:0002345)1.75942507
146Abnormal ciliary motility (HP:0012262)1.75871460
147EEG with generalized epileptiform discharges (HP:0011198)1.75778987
148Abnormality of the pulmonary veins (HP:0011718)1.75018059
149Germ cell neoplasia (HP:0100728)1.74688236
150Epileptiform EEG discharges (HP:0011182)1.74632074
151Akinesia (HP:0002304)1.74576969
152Spastic gait (HP:0002064)1.73776103
153Abnormality of the columella (HP:0009929)1.73315559
154Abnormality of the aortic arch (HP:0012303)1.73080570
155Shawl scrotum (HP:0000049)1.72621162
156Nail dystrophy (HP:0008404)1.72450862
157Bronchitis (HP:0012387)1.71836475
158Abnormal hair laboratory examination (HP:0003328)1.71469334
159Abnormality of cells of the lymphoid lineage (HP:0012140)1.71382590
160Congenital sensorineural hearing impairment (HP:0008527)1.71094769
161Hyperparathyroidism (HP:0000843)1.70974634
162Volvulus (HP:0002580)1.70760585
163Abnormality of the diencephalon (HP:0010662)1.70744701
164Genetic anticipation (HP:0003743)1.70524380
165Neoplasm of the oral cavity (HP:0100649)1.70387044
166Cardiomegaly (HP:0001640)1.69831507
167Pachygyria (HP:0001302)1.69649266
168Neutropenia (HP:0001875)1.69593998
169Optic nerve coloboma (HP:0000588)1.68092331
170Thick nail (HP:0001805)1.67760757
171Hypoproteinemia (HP:0003075)1.67583603
172Deformed sella turcica (HP:0002681)1.67181665
173Aplasia/Hypoplasia of the spleen (HP:0010451)1.66589787
174Easy fatigability (HP:0003388)1.66315881
175Specific learning disability (HP:0001328)1.66178654
176Recurrent fungal infections (HP:0002841)1.66107505
177Tibial bowing (HP:0002982)1.65069201
178Migraine (HP:0002076)1.64966372
179Hypoplasia of dental enamel (HP:0006297)1.64179860
180Abnormality of the 4th metacarpal (HP:0010012)1.64010789
181Lissencephaly (HP:0001339)1.62025859
182Hypoplasia of the brainstem (HP:0002365)1.61337743
183Aplasia/Hypoplasia of the brainstem (HP:0007362)1.61337743
184Blue irides (HP:0000635)1.60480103
185Increased circulating renin level (HP:0000848)1.60381819
186Nephrogenic diabetes insipidus (HP:0009806)1.60059039
187Taurodontia (HP:0000679)1.59071346
188Abnormality of permanent molar morphology (HP:0011071)1.59071346
189Abnormality of the dental root (HP:0006486)1.59071346
190Down-sloping shoulders (HP:0200021)1.58900644
191Medial flaring of the eyebrow (HP:0010747)1.58514130
192Abnormal drinking behavior (HP:0030082)1.58088424
193Polydipsia (HP:0001959)1.58088424
194Congenital primary aphakia (HP:0007707)1.57964680
195Truncal ataxia (HP:0002078)1.55975505
196Dynein arm defect of respiratory motile cilia (HP:0012255)1.55957280
197Absent/shortened dynein arms (HP:0200106)1.55957280
198Spastic tetraplegia (HP:0002510)1.54602782

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K5.23801923
2MARK14.38496065
3TIE13.66167998
4CASK3.52821719
5KIT3.36757927
6TGFBR13.16864711
7NTRK23.09162438
8NTRK32.70704575
9TGFBR22.44202402
10MAP4K12.41460577
11FLT32.37381101
12MATK2.34329757
13BTK2.34306586
14TRIB32.27329380
15EPHB22.27226271
16RPS6KB22.23572096
17TYRO32.20072506
18LMTK22.15958527
19PRKD32.12733965
20CDK192.06225994
21PKN22.04818735
22JAK31.99280735
23TNIK1.96495817
24MAPKAPK51.89505578
25MAP3K101.89427445
26MAP2K31.88900262
27NTRK11.88359732
28PASK1.84391134
29ICK1.84229914
30EPHA21.81840328
31PRKCH1.81176331
32STK161.78832904
33SIK21.75585888
34MAPKAPK31.73861956
35SIK11.72123098
36CSF1R1.71651375
37DYRK21.71272927
38NME21.58130721
39TEC1.47181476
40ZAP701.41969022
41EPHA41.38347131
42PHKG21.34360873
43PHKG11.34360873
44SGK2231.32235514
45SGK4941.32235514
46WEE11.30510600
47MAPK151.30098109
48ERN11.25657851
49TAOK31.24552165
50LRRK21.24504925
51PAK41.19554833
52HIPK21.17540150
53BCKDK1.16104872
54MAP2K71.15008588
55PIM21.14997727
56DYRK1B1.14618463
57MAP3K121.13744034
58RIPK11.13577358
59UHMK11.13445583
60PAK61.13416871
61SCYL21.13212073
62PNCK1.13186987
63MKNK11.12885057
64MUSK1.10756749
65SYK1.09395898
66ERBB21.09219968
67DYRK31.08651944
68MAP3K21.06932555
69FES1.06095810
70BRSK21.05022989
71PKN11.04334761
72VRK11.04129651
73CDK51.02278658
74CAMK2B1.01925317
75NEK61.01370543
76PINK11.01325849
77MINK11.00673030
78CDK81.00071512
79TBK10.97052203
80MAP3K40.89138590
81STK380.88864060
82SGK20.88615551
83CCNB10.88153729
84CAMK2G0.88036807
85CDC70.84257457
86PRKCG0.82732731
87CSNK1G20.81751854
88CAMK2D0.81706209
89IKBKE0.81022200
90EPHB10.78860994
91ACVR1B0.78193443
92KDR0.77158384
93MAPK40.76433735
94PTK60.76298818
95MAP2K20.75008025
96CAMKK20.72970038
97MST1R0.72944256
98TESK10.72665492
99TSSK60.72178430
100SGK30.71180714
101WNK40.70437079
102ILK0.70381514
103FER0.69352602
104FGFR20.69106356
105ROCK20.68751511
106MAPK110.67871855
107MAP2K60.67857101
108LCK0.67680341
109DYRK1A0.67352346
110PAK30.66003592
111NLK0.65668768
112LYN0.65650687
113PTK20.65519344
114MAP3K70.65281569
115STK110.65245237
116MET0.63054455
117ATR0.62712048
118CDK70.62374147
119MAP3K60.61487501
120CDK40.61292149
121PRKCZ0.61217475
122KSR10.61194647
123CLK10.60907388
124TYK20.60588529
125CAMKK10.60565940
126BMPR1B0.60481708
127CAMK2A0.58727468
128MAP2K40.57757589
129KSR20.56761890
130MAP3K90.55216875
131WNK30.54098348
132PRKG20.52618300
133CAMK10.52566901
134DAPK20.52455743
135RPS6KA40.52265800
136HCK0.51837522
137FYN0.51401172
138ARAF0.50660581
139CSNK1G30.50019354
140MARK20.49589684
141TAOK10.49556173
142PIM10.49025459
143RPS6KA20.48268933
144NEK20.48176462
145PRKD10.47280038
146STK100.47155553
147TNK20.46642232
148PIK3CG0.46498347
149IRAK40.45800189
150TRPM70.45673306
151ROCK10.45481544
152RPS6KA60.45379614
153CAMK1G0.44166104
154BCR0.43233546
155SGK10.43111686
156RPS6KA10.43018562
157PRPF4B0.42932575
158IKBKB0.42653104
159FGFR30.42288125
160SRC0.41993916
161MAPK130.41718389
162PDGFRB0.40910335
163CDK30.40486578
164CSNK1A1L0.40360935
165SIK30.40124198
166DAPK10.39794650
167RET0.38916477
168MTOR0.38864667
169PRKD20.36867259
170FGFR40.34860172
171RPS6KC10.34556511
172RPS6KL10.34556511
173MAPK30.34420767
174BRSK10.34341741
175MAPKAPK20.32069887
176EPHA30.31642674
177CDK90.30245015
178PAK20.29427147
179CDK60.27983914

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.45918726
2Ribosome_Homo sapiens_hsa030103.93162239
3Mismatch repair_Homo sapiens_hsa034303.00293145
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.81070489
5Base excision repair_Homo sapiens_hsa034102.67836086
6B cell receptor signaling pathway_Homo sapiens_hsa046622.19312259
7Axon guidance_Homo sapiens_hsa043602.18886422
8Primary immunodeficiency_Homo sapiens_hsa053402.17119018
9Nicotine addiction_Homo sapiens_hsa050332.09706869
10Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.07080069
11N-Glycan biosynthesis_Homo sapiens_hsa005102.04377563
12Platelet activation_Homo sapiens_hsa046112.03100036
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.99413042
14Spliceosome_Homo sapiens_hsa030401.91580013
15Acute myeloid leukemia_Homo sapiens_hsa052211.89450477
16Insulin secretion_Homo sapiens_hsa049111.85215222
17Circadian entrainment_Homo sapiens_hsa047131.83383672
18Synaptic vesicle cycle_Homo sapiens_hsa047211.82767083
19Transcriptional misregulation in cancer_Homo sapiens_hsa052021.82089789
20Glutamatergic synapse_Homo sapiens_hsa047241.81208511
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.77220717
22Gastric acid secretion_Homo sapiens_hsa049711.71656601
23GABAergic synapse_Homo sapiens_hsa047271.65645430
24Thyroid hormone synthesis_Homo sapiens_hsa049181.64590796
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.64269682
26Other glycan degradation_Homo sapiens_hsa005111.63020989
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.61894597
28Cocaine addiction_Homo sapiens_hsa050301.61020916
29Chronic myeloid leukemia_Homo sapiens_hsa052201.58306818
30Antigen processing and presentation_Homo sapiens_hsa046121.55591828
31Dorso-ventral axis formation_Homo sapiens_hsa043201.53753032
32Pyrimidine metabolism_Homo sapiens_hsa002401.53713533
33Dopaminergic synapse_Homo sapiens_hsa047281.51589307
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51469983
35Nucleotide excision repair_Homo sapiens_hsa034201.50883802
36Cell cycle_Homo sapiens_hsa041101.49812892
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48653692
38Homologous recombination_Homo sapiens_hsa034401.47530684
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45965132
40Morphine addiction_Homo sapiens_hsa050321.43908986
41Herpes simplex infection_Homo sapiens_hsa051681.43349903
42Hematopoietic cell lineage_Homo sapiens_hsa046401.42707357
43Measles_Homo sapiens_hsa051621.41756047
44Cholinergic synapse_Homo sapiens_hsa047251.40023510
45Non-homologous end-joining_Homo sapiens_hsa034501.36274862
46Leishmaniasis_Homo sapiens_hsa051401.35428852
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.32455763
48Jak-STAT signaling pathway_Homo sapiens_hsa046301.32136775
49Shigellosis_Homo sapiens_hsa051311.31995915
50Long-term depression_Homo sapiens_hsa047301.28233002
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24641161
52Notch signaling pathway_Homo sapiens_hsa043301.22721770
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.21557225
54Endometrial cancer_Homo sapiens_hsa052131.19172833
55ErbB signaling pathway_Homo sapiens_hsa040121.17616980
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.16469689
57Amphetamine addiction_Homo sapiens_hsa050311.15469865
58Thyroid cancer_Homo sapiens_hsa052161.15243103
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.14596451
60Non-small cell lung cancer_Homo sapiens_hsa052231.13893220
61Glycosaminoglycan degradation_Homo sapiens_hsa005311.12599161
62Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12391678
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11771386
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11457797
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11409157
66Hepatitis B_Homo sapiens_hsa051611.09500155
67Salivary secretion_Homo sapiens_hsa049701.09366345
68Melanogenesis_Homo sapiens_hsa049161.09026782
69Estrogen signaling pathway_Homo sapiens_hsa049151.08276427
70Gap junction_Homo sapiens_hsa045401.08260586
71cAMP signaling pathway_Homo sapiens_hsa040241.05061473
72RNA degradation_Homo sapiens_hsa030181.03187140
73Phospholipase D signaling pathway_Homo sapiens_hsa040721.02307524
74Osteoclast differentiation_Homo sapiens_hsa043801.00808851
75Neurotrophin signaling pathway_Homo sapiens_hsa047221.00742600
76Collecting duct acid secretion_Homo sapiens_hsa049660.99473131
77Long-term potentiation_Homo sapiens_hsa047200.98983907
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98664943
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.97429660
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.96481376
81Bile secretion_Homo sapiens_hsa049760.96339227
82Hippo signaling pathway_Homo sapiens_hsa043900.94773053
83Phototransduction_Homo sapiens_hsa047440.94524638
84Pancreatic secretion_Homo sapiens_hsa049720.94249570
85Choline metabolism in cancer_Homo sapiens_hsa052310.90762738
86Renin secretion_Homo sapiens_hsa049240.90756317
87Serotonergic synapse_Homo sapiens_hsa047260.90645901
88Rap1 signaling pathway_Homo sapiens_hsa040150.90421646
89Prolactin signaling pathway_Homo sapiens_hsa049170.90373637
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89460025
91Basal cell carcinoma_Homo sapiens_hsa052170.89356321
92Dilated cardiomyopathy_Homo sapiens_hsa054140.89051438
93Prion diseases_Homo sapiens_hsa050200.89033331
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88598285
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87826978
96Colorectal cancer_Homo sapiens_hsa052100.87416517
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86729836
98Oxytocin signaling pathway_Homo sapiens_hsa049210.86449047
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86067910
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85989780
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85500888
102Influenza A_Homo sapiens_hsa051640.85270106
103Purine metabolism_Homo sapiens_hsa002300.84605061
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83480787
105Pancreatic cancer_Homo sapiens_hsa052120.82504780
106Vibrio cholerae infection_Homo sapiens_hsa051100.81951371
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81534602
108Folate biosynthesis_Homo sapiens_hsa007900.80346543
109Hedgehog signaling pathway_Homo sapiens_hsa043400.79645121
110Toxoplasmosis_Homo sapiens_hsa051450.79461671
111Ras signaling pathway_Homo sapiens_hsa040140.78944818
112Renal cell carcinoma_Homo sapiens_hsa052110.76920498
113GnRH signaling pathway_Homo sapiens_hsa049120.76153827
114Ovarian steroidogenesis_Homo sapiens_hsa049130.75034780
115Pentose phosphate pathway_Homo sapiens_hsa000300.75006619
116Taste transduction_Homo sapiens_hsa047420.74954197
117Legionellosis_Homo sapiens_hsa051340.74606930
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.74430016
119NF-kappa B signaling pathway_Homo sapiens_hsa040640.73936991
120HTLV-I infection_Homo sapiens_hsa051660.73669891
121Ether lipid metabolism_Homo sapiens_hsa005650.73600453
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72563320
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71475906
124ECM-receptor interaction_Homo sapiens_hsa045120.70896490
125Protein export_Homo sapiens_hsa030600.70253593
126Steroid biosynthesis_Homo sapiens_hsa001000.69420513
127Apoptosis_Homo sapiens_hsa042100.69138118
128Pertussis_Homo sapiens_hsa051330.68949515
129Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67814210
130Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67711493
131Epstein-Barr virus infection_Homo sapiens_hsa051690.67232293
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.66847014
133Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66674394
134Sulfur relay system_Homo sapiens_hsa041220.65257780
135Cardiac muscle contraction_Homo sapiens_hsa042600.64952129
136Nitrogen metabolism_Homo sapiens_hsa009100.64626827
137RNA polymerase_Homo sapiens_hsa030200.64409216
138Glioma_Homo sapiens_hsa052140.64119266
139SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63877762
140Endocytosis_Homo sapiens_hsa041440.63709753
141AMPK signaling pathway_Homo sapiens_hsa041520.63063950
142Glycerolipid metabolism_Homo sapiens_hsa005610.62527876
143RNA transport_Homo sapiens_hsa030130.62169487
144Small cell lung cancer_Homo sapiens_hsa052220.61413051
145Vascular smooth muscle contraction_Homo sapiens_hsa042700.60677314
146ABC transporters_Homo sapiens_hsa020100.60298598
147Type II diabetes mellitus_Homo sapiens_hsa049300.57411585
148Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57053475
149Viral carcinogenesis_Homo sapiens_hsa052030.56988222
150Circadian rhythm_Homo sapiens_hsa047100.56001417
151Selenocompound metabolism_Homo sapiens_hsa004500.55978863
152MAPK signaling pathway_Homo sapiens_hsa040100.55083661
153Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55019960
154Cyanoamino acid metabolism_Homo sapiens_hsa004600.54538933
155Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53396133
156Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53036540
157Calcium signaling pathway_Homo sapiens_hsa040200.51510417
158Fanconi anemia pathway_Homo sapiens_hsa034600.50470214
159Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49665024
160Tight junction_Homo sapiens_hsa045300.49636640
161Insulin signaling pathway_Homo sapiens_hsa049100.49584455
162Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49213852
163Galactose metabolism_Homo sapiens_hsa000520.47739525
164Hepatitis C_Homo sapiens_hsa051600.47691924
165Fatty acid biosynthesis_Homo sapiens_hsa000610.47520238
166VEGF signaling pathway_Homo sapiens_hsa043700.47514034
167Linoleic acid metabolism_Homo sapiens_hsa005910.46350508
168Wnt signaling pathway_Homo sapiens_hsa043100.45564944
169Insulin resistance_Homo sapiens_hsa049310.45250866
170Olfactory transduction_Homo sapiens_hsa047400.44945790
171Intestinal immune network for IgA production_Homo sapiens_hsa046720.43773625
172Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42334379
173Central carbon metabolism in cancer_Homo sapiens_hsa052300.41935012
174Pathways in cancer_Homo sapiens_hsa052000.41774577
175Adipocytokine signaling pathway_Homo sapiens_hsa049200.41304901
176Chemokine signaling pathway_Homo sapiens_hsa040620.39998835
177Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.39390190
178Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39206260
179TNF signaling pathway_Homo sapiens_hsa046680.38104469
180p53 signaling pathway_Homo sapiens_hsa041150.37915091
181Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37901828
182Salmonella infection_Homo sapiens_hsa051320.34516067
183Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33559387
184Inositol phosphate metabolism_Homo sapiens_hsa005620.33074034
185Malaria_Homo sapiens_hsa051440.32730760

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