ADGRG4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a G-protein coupled receptor belonging to a large family of diverse integral membrane proteins that participate in various physiological functions. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The ligand for this family member is unknown, and it is therefore an orphan receptor. This receptor is known to be expressed in normal enterochromaffin cells and in gastrointestinal neuroendocrine carcinoma cells, and it is therefore considered to be a novel biomarker or target for immunotherapy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.78204902
2positive regulation of cellular amide metabolic process (GO:0034250)5.39233169
3superoxide anion generation (GO:0042554)5.06574799
4regulation of activation of Janus kinase activity (GO:0010533)5.02952922
5ATP synthesis coupled proton transport (GO:0015986)5.02095678
6energy coupled proton transport, down electrochemical gradient (GO:0015985)5.02095678
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.80061241
8electron transport chain (GO:0022900)4.56530428
9respiratory electron transport chain (GO:0022904)4.56158958
10indolalkylamine metabolic process (GO:0006586)4.28684023
11transcription elongation from RNA polymerase III promoter (GO:0006385)4.26311734
12termination of RNA polymerase III transcription (GO:0006386)4.26311734
13detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.16378728
14regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.13766279
15positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.12568869
16mitochondrial respiratory chain complex assembly (GO:0033108)4.08127970
17protein complex biogenesis (GO:0070271)4.01090887
18respiratory chain complex IV assembly (GO:0008535)4.01020193
19cytochrome complex assembly (GO:0017004)3.96514816
20behavioral response to nicotine (GO:0035095)3.96193261
21establishment of protein localization to mitochondrial membrane (GO:0090151)3.95071114
22kynurenine metabolic process (GO:0070189)3.79078052
23response to peptidoglycan (GO:0032494)3.78591230
24dopamine transport (GO:0015872)3.71682043
25dendritic cell chemotaxis (GO:0002407)3.71322946
26positive regulation of interleukin-1 beta secretion (GO:0050718)3.69283382
27indole-containing compound catabolic process (GO:0042436)3.67101308
28indolalkylamine catabolic process (GO:0046218)3.67101308
29tryptophan catabolic process (GO:0006569)3.67101308
30hydrogen ion transmembrane transport (GO:1902600)3.66866198
31proton transport (GO:0015992)3.63405477
32positive regulation by organism of defense response of other organism involved in symbiotic interact3.58879621
33modulation by symbiont of host immune response (GO:0052553)3.58879621
34positive regulation by symbiont of host defense response (GO:0052509)3.58879621
35modulation by symbiont of host defense response (GO:0052031)3.58879621
36modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.58879621
37modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.58879621
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.57765705
39NADH dehydrogenase complex assembly (GO:0010257)3.57765705
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.57765705
41regulation of memory T cell differentiation (GO:0043380)3.56594648
42behavioral response to ethanol (GO:0048149)3.55786352
43hydrogen transport (GO:0006818)3.54366268
44cellular extravasation (GO:0045123)3.52106517
45negative regulation of multicellular organism growth (GO:0040015)3.49111817
46sulfation (GO:0051923)3.46374273
47regulation of RIG-I signaling pathway (GO:0039535)3.45938988
48pseudouridine synthesis (GO:0001522)3.43692353
49chaperone-mediated protein transport (GO:0072321)3.42591158
50CENP-A containing nucleosome assembly (GO:0034080)3.41612256
51daunorubicin metabolic process (GO:0044597)3.41562035
52polyketide metabolic process (GO:0030638)3.41562035
53doxorubicin metabolic process (GO:0044598)3.41562035
54regulation of establishment of cell polarity (GO:2000114)3.38034633
55chromatin remodeling at centromere (GO:0031055)3.37613122
56regulation of interleukin-1 beta secretion (GO:0050706)3.37052910
57positive regulation of interleukin-1 secretion (GO:0050716)3.36539188
58regulation of dendritic cell antigen processing and presentation (GO:0002604)3.34529087
59positive regulation of interleukin-17 production (GO:0032740)3.33788440
60water-soluble vitamin biosynthetic process (GO:0042364)3.31477892
61response to host immune response (GO:0052572)3.30891792
62response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.30891792
63DNA deamination (GO:0045006)3.30431538
64positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.29737729
65regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.25083759
66superoxide metabolic process (GO:0006801)3.24575874
67regulation of posttranscriptional gene silencing (GO:0060147)3.23664507
68regulation of gene silencing by miRNA (GO:0060964)3.23664507
69regulation of gene silencing by RNA (GO:0060966)3.23664507
70dendritic cell migration (GO:0036336)3.19654947
71positive regulation of antigen processing and presentation (GO:0002579)3.15165311
72protein neddylation (GO:0045116)3.14815592
73cellular anion homeostasis (GO:0030002)3.12169192
74sex differentiation (GO:0007548)3.11201065
75myeloid dendritic cell activation (GO:0001773)3.09615428
76natural killer cell activation involved in immune response (GO:0002323)3.08874034
77positive regulation of interleukin-12 production (GO:0032735)3.06130657
78germinal center formation (GO:0002467)3.04638037
79cholesterol catabolic process (GO:0006707)3.03678717
80sterol catabolic process (GO:0016127)3.03678717
81photoreceptor cell maintenance (GO:0045494)3.02880404
82ATP biosynthetic process (GO:0006754)3.02852019
83microglial cell activation (GO:0001774)3.01400200
84detection of molecule of bacterial origin (GO:0032490)3.00862170
85neutrophil activation involved in immune response (GO:0002283)2.99597271
86tryptophan metabolic process (GO:0006568)2.99003774
87neuromuscular process controlling posture (GO:0050884)2.97722778
88positive regulation of DNA-dependent DNA replication (GO:2000105)2.95173745
89nucleoside diphosphate catabolic process (GO:0009134)2.95146202
90adult feeding behavior (GO:0008343)2.94641998
91myeloid dendritic cell differentiation (GO:0043011)2.92645037
92cerebral cortex radially oriented cell migration (GO:0021799)2.92399880
93translational termination (GO:0006415)2.92279466
94detection of other organism (GO:0098543)2.91927184
95positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.88709431
96regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.88709431
97negative regulation of viral genome replication (GO:0045071)2.84092803
98regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.84004172
99antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.82997147
100regulation of establishment or maintenance of cell polarity (GO:0032878)2.82460008
101response to host (GO:0075136)2.81279920
102response to host defenses (GO:0052200)2.81279920
103response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.81279920
104reflex (GO:0060004)2.80837331
105piRNA metabolic process (GO:0034587)2.79049509
106regulation of cellular extravasation (GO:0002691)2.78730669
107regulation of interleukin-1 secretion (GO:0050704)2.76414886
108oligosaccharide catabolic process (GO:0009313)2.73958526
109indole-containing compound metabolic process (GO:0042430)2.73683124
110nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.72870446
111positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.72618357
112respiratory burst (GO:0045730)2.72599982
113viral transcription (GO:0019083)2.71619831
114neutrophil activation (GO:0042119)2.70851721
115neural tube formation (GO:0001841)2.70183063
116negative regulation of homotypic cell-cell adhesion (GO:0034111)2.70107573
117G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.69889009
118acrosome assembly (GO:0001675)2.68919305
119regulation of interleukin-17 production (GO:0032660)2.68791908
120positive regulation of interleukin-1 beta production (GO:0032731)2.68630569
121detection of light stimulus involved in sensory perception (GO:0050962)2.68460127
122detection of light stimulus involved in visual perception (GO:0050908)2.68460127
123positive regulation of T-helper 1 type immune response (GO:0002827)2.66892237
124histone exchange (GO:0043486)2.66234562
125regulation of MHC class I biosynthetic process (GO:0045343)2.65885885
126regulation of T-helper 1 cell differentiation (GO:0045625)2.65814399
127regulation of germinal center formation (GO:0002634)2.65697888
128protein K6-linked ubiquitination (GO:0085020)2.65464265
129spliceosomal complex assembly (GO:0000245)2.65221083
130positive regulation of interleukin-10 production (GO:0032733)2.65177303
131response to muramyl dipeptide (GO:0032495)2.64762957
132positive regulation of monocyte chemotaxis (GO:0090026)2.63938903
133purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.62790067
134NIK/NF-kappaB signaling (GO:0038061)2.62287954
135prostate gland growth (GO:0060736)2.59191828
136L-fucose catabolic process (GO:0042355)2.59087084
137fucose catabolic process (GO:0019317)2.59087084
138L-fucose metabolic process (GO:0042354)2.59087084
139hydrogen peroxide biosynthetic process (GO:0050665)2.58543739
140male meiosis I (GO:0007141)2.57686338
141purine nucleoside triphosphate biosynthetic process (GO:0009145)2.57668234
142regulation of antigen processing and presentation (GO:0002577)2.57291244
143regulation of mitochondrial translation (GO:0070129)2.57034945
144granulocyte activation (GO:0036230)2.56845818
145macrophage activation involved in immune response (GO:0002281)2.56836294
146regulation of collateral sprouting (GO:0048670)2.56317330
147purine ribonucleotide transport (GO:0015868)2.55992564
148preassembly of GPI anchor in ER membrane (GO:0016254)2.55633418
149exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.55599310
150auditory receptor cell stereocilium organization (GO:0060088)2.55452716
151positive regulation of heat generation (GO:0031652)2.55104041
152synaptic vesicle endocytosis (GO:0048488)2.54595759
153positive regulation of interleukin-1 production (GO:0032732)2.52572879
154positive regulation of interferon-gamma production (GO:0032729)2.52356092
155meiotic chromosome segregation (GO:0045132)2.51806655
156DNA damage response, detection of DNA damage (GO:0042769)2.51370364
157adenine nucleotide transport (GO:0051503)2.50515707
158positive regulation of guanylate cyclase activity (GO:0031284)2.50431379
159fat-soluble vitamin catabolic process (GO:0042363)2.47133212
160vitamin catabolic process (GO:0009111)2.47133212
161rRNA modification (GO:0000154)2.46960742
162negative regulation of mast cell activation (GO:0033004)2.46950551
163platelet dense granule organization (GO:0060155)2.46327360
164positive regulation of alpha-beta T cell proliferation (GO:0046641)2.46182697
165cotranslational protein targeting to membrane (GO:0006613)2.45655410
166regulation of rhodopsin mediated signaling pathway (GO:0022400)2.45503409
167SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.44880511
168regulation of timing of cell differentiation (GO:0048505)2.44599715
169detection of bacterium (GO:0016045)2.44270821
170meiosis I (GO:0007127)2.43876701
171mesenchymal to epithelial transition (GO:0060231)2.43588257
172eosinophil migration (GO:0072677)2.43493273
173positive regulation of T-helper cell differentiation (GO:0045624)2.43439366
174transmission of nerve impulse (GO:0019226)2.43365026
175regulation of nuclear cell cycle DNA replication (GO:0033262)2.43029060
176G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.43021263
177G-protein coupled receptor internalization (GO:0002031)2.42939410
178aminoglycoside antibiotic metabolic process (GO:0030647)2.42829388
179T-helper 1 type immune response (GO:0042088)2.42481323
180positive regulation of type 2 immune response (GO:0002830)2.42363149
181T-helper cell differentiation (GO:0042093)2.42048032
182CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.42048032
183negative regulation of cytosolic calcium ion concentration (GO:0051481)2.41165706
184intracellular protein transmembrane import (GO:0044743)2.40824068
185recombinational repair (GO:0000725)2.40718742
186mannosylation (GO:0097502)2.39611056
187protein targeting to ER (GO:0045047)2.39605139
188double-strand break repair via homologous recombination (GO:0000724)2.39483407
189ADP metabolic process (GO:0046031)2.39448556
190neuronal action potential (GO:0019228)2.39421204
191eosinophil chemotaxis (GO:0048245)2.38513697
192establishment of protein localization to endoplasmic reticulum (GO:0072599)2.37970897
193regulation of interferon-gamma biosynthetic process (GO:0045072)2.37792312
194axoneme assembly (GO:0035082)2.37447523
195dentate gyrus development (GO:0021542)2.37064016
196exogenous drug catabolic process (GO:0042738)2.36682909
197negative regulation of interleukin-17 production (GO:0032700)2.35537431
198reactive oxygen species biosynthetic process (GO:1903409)2.34945854

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.59991665
2GBX2_23144817_ChIP-Seq_PC3_Human3.54572837
3ZNF274_21170338_ChIP-Seq_K562_Hela3.01043912
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.70679332
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.66302322
6EZH2_22144423_ChIP-Seq_EOC_Human2.65474694
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.64106998
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.56827613
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.54461785
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.36817299
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36166995
12SUZ12_27294783_Chip-Seq_NPCs_Mouse2.27791036
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.26137100
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.25485554
15NFE2_27457419_Chip-Seq_LIVER_Mouse2.20891562
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.16925089
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.12411534
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.12020314
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.09742385
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.07675233
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.07173288
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06122742
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.05829450
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.02520015
25PCGF2_27294783_Chip-Seq_NPCs_Mouse1.96491514
26EZH2_27294783_Chip-Seq_NPCs_Mouse1.91995127
27EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.89522078
28TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.87719752
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.87391399
30P300_19829295_ChIP-Seq_ESCs_Human1.87355120
31IGF1R_20145208_ChIP-Seq_DFB_Human1.87016199
32SUZ12_18555785_Chip-Seq_ESCs_Mouse1.85149013
33NANOG_18555785_Chip-Seq_ESCs_Mouse1.84687535
34STAT3_18555785_Chip-Seq_ESCs_Mouse1.84535895
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.84056795
36P53_22387025_ChIP-Seq_ESCs_Mouse1.83267701
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.82139450
38E2F1_18555785_Chip-Seq_ESCs_Mouse1.82066939
39BCAT_22108803_ChIP-Seq_LS180_Human1.79620846
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77820277
41FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.75069559
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.72911370
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72511389
44CMYC_18555785_Chip-Seq_ESCs_Mouse1.71843263
45NMYC_18555785_Chip-Seq_ESCs_Mouse1.67889896
46EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.66140945
47P300_18555785_Chip-Seq_ESCs_Mouse1.62684262
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62501540
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62338864
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.61050001
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.59554637
52SOX2_18555785_Chip-Seq_ESCs_Mouse1.58355820
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56511351
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54690634
55OCT4_18555785_Chip-Seq_ESCs_Mouse1.54372846
56PU1_27457419_Chip-Seq_LIVER_Mouse1.54025962
57RUNX1_27457419_Chip-Seq_LIVER_Mouse1.53403576
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52965311
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.52316494
60IRF8_27001747_Chip-Seq_BMDM_Mouse1.51252365
61CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49609087
62ESRRB_18555785_Chip-Seq_ESCs_Mouse1.49136308
63SMAD4_21799915_ChIP-Seq_A2780_Human1.47903252
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46296969
65ZFX_18555785_Chip-Seq_ESCs_Mouse1.45967091
66VDR_22108803_ChIP-Seq_LS180_Human1.45699982
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.45603236
68KLF4_18555785_Chip-Seq_ESCs_Mouse1.45095338
69SMAD1_18555785_Chip-Seq_ESCs_Mouse1.44561153
70ER_23166858_ChIP-Seq_MCF-7_Human1.43531861
71TP53_22573176_ChIP-Seq_HFKS_Human1.42593175
72CTCF_18555785_Chip-Seq_ESCs_Mouse1.42555791
73IRF1_19129219_ChIP-ChIP_H3396_Human1.41980325
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41388689
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40859772
76SOX2_19829295_ChIP-Seq_ESCs_Human1.40297277
77NANOG_19829295_ChIP-Seq_ESCs_Human1.40297277
78EWS_26573619_Chip-Seq_HEK293_Human1.40145929
79FUS_26573619_Chip-Seq_HEK293_Human1.40097728
80TAL1_26923725_Chip-Seq_HPCs_Mouse1.38980958
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38292647
82TP53_18474530_ChIP-ChIP_U2OS_Human1.38221041
83CRX_20693478_ChIP-Seq_RETINA_Mouse1.37827245
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37375028
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.35577822
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35498632
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35498632
88TCF4_22108803_ChIP-Seq_LS180_Human1.33019705
89OCT4_21477851_ChIP-Seq_ESCs_Mouse1.31482165
90ELK1_19687146_ChIP-ChIP_HELA_Human1.30416282
91SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.30254644
92CBP_20019798_ChIP-Seq_JUKART_Human1.29506109
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29506109
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28339992
95VDR_24787735_ChIP-Seq_THP-1_Human1.27935369
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27381842
97SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27240227
98BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26919482
99TAF15_26573619_Chip-Seq_HEK293_Human1.26506939
100AR_21572438_ChIP-Seq_LNCaP_Human1.26473248
101POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26119588
102EED_16625203_ChIP-ChIP_MESCs_Mouse1.24825581
103NOTCH1_21737748_ChIP-Seq_TLL_Human1.22991222
104ETV2_25802403_ChIP-Seq_MESCs_Mouse1.22862959
105OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22722543
106LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22225309
107SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21791826
108SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20922880
109MYC_18940864_ChIP-ChIP_HL60_Human1.20426687
110AR_25329375_ChIP-Seq_VCAP_Human1.20207303
111CDX2_22108803_ChIP-Seq_LS180_Human1.19293931
112SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19089396
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17253221
114STAT3_23295773_ChIP-Seq_U87_Human1.17061957
115AR_20517297_ChIP-Seq_VCAP_Human1.16934385
116SMAD3_21741376_ChIP-Seq_EPCs_Human1.16367230
117FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15912402
118FOXA1_25329375_ChIP-Seq_VCAP_Human1.15912402
119KDM2B_26808549_Chip-Seq_REH_Human1.15588677
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13384674
121UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13292015
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13027652
123GATA2_21666600_ChIP-Seq_HMVEC_Human1.12286178
124REST_21632747_ChIP-Seq_MESCs_Mouse1.12245987
125ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10960474
126FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10241445
127GATA3_21878914_ChIP-Seq_MCF-7_Human1.09739811
128KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09261214
129JARID2_20064375_ChIP-Seq_MESCs_Mouse1.05969025
130STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.05905999
131P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05786435
132RNF2_27304074_Chip-Seq_NSC_Mouse1.05494778
133FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04472431
134PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04257136
135SMAD4_21741376_ChIP-Seq_EPCs_Human1.04251720
136TCF4_18268006_ChIP-ChIP_LS174T_Human1.04077038
137FLI1_21867929_ChIP-Seq_TH2_Mouse1.03676565
138HTT_18923047_ChIP-ChIP_STHdh_Human1.03594640
139NCOR_22424771_ChIP-Seq_293T_Human1.03109499
140TCF4_23295773_ChIP-Seq_U87_Human1.02750447
141STAT1_17558387_ChIP-Seq_HELA_Human1.02457963
142ETS1_20019798_ChIP-Seq_JURKAT_Human1.02082938
143RUNX2_22187159_ChIP-Seq_PCA_Human1.02070132
144NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01694574
145SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01569112
146PRDM14_20953172_ChIP-Seq_ESCs_Human1.01552540
147ETV1_20927104_ChIP-Seq_GIST48_Human0.96473986
148NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96147948
149OCT1_27270436_Chip-Seq_PROSTATE_Human0.95864504

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis4.03703905
2MP0006292_abnormal_olfactory_placode3.67416720
3MP0001835_abnormal_antigen_presentation3.62141546
4MP0009697_abnormal_copulation3.35834019
5MP0003011_delayed_dark_adaptation2.98031112
6MP0009785_altered_susceptibility_to2.85446284
7MP0003718_maternal_effect2.83533818
8MP0002148_abnormal_hypersensitivity_rea2.82354055
9MP0002876_abnormal_thyroid_physiology2.81929389
10MP0001188_hyperpigmentation2.65225310
11MP0009379_abnormal_foot_pigmentation2.58159352
12MP0005645_abnormal_hypothalamus_physiol2.56648140
13MP0005551_abnormal_eye_electrophysiolog2.50223794
14MP0003183_abnormal_peptide_metabolism2.43826602
15MP0006072_abnormal_retinal_apoptosis2.41638746
16MP0005360_urolithiasis2.33488790
17MP0002938_white_spotting2.31415499
18MP0002102_abnormal_ear_morphology2.26993266
19MP0004510_myositis2.23725361
20MP0001790_abnormal_immune_system2.14345205
21MP0005387_immune_system_phenotype2.14345205
22MP0003252_abnormal_bile_duct2.10642759
23MP0008877_abnormal_DNA_methylation2.07757014
24MP0002419_abnormal_innate_immunity2.04830537
25MP0006082_CNS_inflammation1.94840871
26MP0004782_abnormal_surfactant_physiolog1.94007149
27MP0005000_abnormal_immune_tolerance1.90910443
28MP0009745_abnormal_behavioral_response1.90626564
29MP0005670_abnormal_white_adipose1.89673556
30MP0005671_abnormal_response_to1.89533763
31MP0001485_abnormal_pinna_reflex1.89198927
32MP0003195_calcinosis1.88250253
33MP0005025_abnormal_response_to1.82761378
34MP0005085_abnormal_gallbladder_physiolo1.80687639
35MP0008872_abnormal_physiological_respon1.80250409
36MP0005310_abnormal_salivary_gland1.78583195
37MP0005253_abnormal_eye_physiology1.77682464
38MP0003436_decreased_susceptibility_to1.77332181
39MP0005171_absent_coat_pigmentation1.73821005
40MP0002638_abnormal_pupillary_reflex1.73345712
41MP0001986_abnormal_taste_sensitivity1.68412395
42MP0003880_abnormal_central_pattern1.63739432
43MP0002272_abnormal_nervous_system1.63055813
44MP0009764_decreased_sensitivity_to1.63047530
45MP0000343_altered_response_to1.62778678
46MP0002735_abnormal_chemical_nociception1.62673655
47MP0004019_abnormal_vitamin_homeostasis1.62646202
48MP0002452_abnormal_antigen_presenting1.62487610
49MP0005646_abnormal_pituitary_gland1.60227704
50MP0002277_abnormal_respiratory_mucosa1.58449038
51MP0004142_abnormal_muscle_tone1.54237612
52MP0002163_abnormal_gland_morphology1.53794791
53MP0010386_abnormal_urinary_bladder1.53097105
54MP0000678_abnormal_parathyroid_gland1.52896905
55MP0002736_abnormal_nociception_after1.52617234
56MP0009046_muscle_twitch1.51348153
57MP0002723_abnormal_immune_serum1.51063805
58MP0001853_heart_inflammation1.50642138
59MP0000631_abnormal_neuroendocrine_gland1.50471688
60MP0000685_abnormal_immune_system1.48560720
61MP0000015_abnormal_ear_pigmentation1.46937297
62MP0001800_abnormal_humoral_immune1.43013723
63MP0001819_abnormal_immune_cell1.42196482
64MP0000516_abnormal_urinary_system1.40542860
65MP0005367_renal/urinary_system_phenotyp1.40542860
66MP0002420_abnormal_adaptive_immunity1.36978930
67MP0001486_abnormal_startle_reflex1.35924672
68MP0008961_abnormal_basal_metabolism1.35907642
69MP0002733_abnormal_thermal_nociception1.34041004
70MP0002254_reproductive_system_inflammat1.33277653
71MP0001984_abnormal_olfaction1.32724688
72MP0003137_abnormal_impulse_conducting1.31598932
73MP0002837_dystrophic_cardiac_calcinosis1.29386389
74MP0003136_yellow_coat_color1.28771773
75MP0000427_abnormal_hair_cycle1.26460949
76MP0004147_increased_porphyrin_level1.26313871
77MP0000569_abnormal_digit_pigmentation1.25984505
78MP0000538_abnormal_urinary_bladder1.23701545
79MP0001666_abnormal_nutrient_absorption1.23204292
80MP0005377_hearing/vestibular/ear_phenot1.21525042
81MP0003878_abnormal_ear_physiology1.21525042
82MP0003724_increased_susceptibility_to1.20898916
83MP0000681_abnormal_thyroid_gland1.20349075
84MP0004885_abnormal_endolymph1.18713925
85MP0002933_joint_inflammation1.17746085
86MP0001919_abnormal_reproductive_system1.17686021
87MP0006035_abnormal_mitochondrial_morpho1.17346674
88MP0001970_abnormal_pain_threshold1.15060851
89MP0008057_abnormal_DNA_replication1.14223277
90MP0003941_abnormal_skin_development1.12780590
91MP0008260_abnormal_autophagy1.12572914
92MP0002064_seizures1.11984116
93MP0006036_abnormal_mitochondrial_physio1.08750619
94MP0010155_abnormal_intestine_physiology1.08612791
95MP0004043_abnormal_pH_regulation1.08566894
96MP0002138_abnormal_hepatobiliary_system1.08522151
97MP0001845_abnormal_inflammatory_respons1.07885861
98MP0005410_abnormal_fertilization1.07777299
99MP0008995_early_reproductive_senescence1.06650590
100MP0004134_abnormal_chest_morphology1.06642843
101MP0004133_heterotaxia1.04306755
102MP0004215_abnormal_myocardial_fiber1.03608085
103MP0001905_abnormal_dopamine_level1.01868330
104MP0001440_abnormal_grooming_behavior1.01516983
105MP0001873_stomach_inflammation1.01277041
106MP0005075_abnormal_melanosome_morpholog1.00769024
107MP0001324_abnormal_eye_pigmentation1.00706901
108MP0002572_abnormal_emotion/affect_behav0.99136464
109MP0003787_abnormal_imprinting0.97837735
110MP0006276_abnormal_autonomic_nervous0.96857953
111MP0005195_abnormal_posterior_eye0.96714807
112MP0002998_abnormal_bone_remodeling0.95976409
113MP0001664_abnormal_digestion0.95309177
114MP0005379_endocrine/exocrine_gland_phen0.95263540
115MP0005365_abnormal_bile_salt0.94319068
116MP0000371_diluted_coat_color0.93749144
117MP0001968_abnormal_touch/_nociception0.92618160
118MP0005166_decreased_susceptibility_to0.91373349
119MP0005167_abnormal_blood-brain_barrier0.91331868
120MP0002139_abnormal_hepatobiliary_system0.91105106
121MP0005464_abnormal_platelet_physiology0.90442907
122MP0005636_abnormal_mineral_homeostasis0.89974096
123MP0002405_respiratory_system_inflammati0.89829120
124MP0008469_abnormal_protein_level0.89428313
125MP0002693_abnormal_pancreas_physiology0.89350399
126MP0002067_abnormal_sensory_capabilities0.88604708
127MP0001346_abnormal_lacrimal_gland0.87771068
128MP0003448_altered_tumor_morphology0.87197835
129MP0003638_abnormal_response/metabolism_0.86807155
130MP0004742_abnormal_vestibular_system0.85317627
131MP0009250_abnormal_appendicular_skeleto0.85270927
132MP0005389_reproductive_system_phenotype0.85076659
133MP0001502_abnormal_circadian_rhythm0.84727868
134MP0000716_abnormal_immune_system0.84406088
135MP0002557_abnormal_social/conspecific_i0.84197155
136MP0005248_abnormal_Harderian_gland0.84122032
137MP0003646_muscle_fatigue0.83747601
138MP0008058_abnormal_DNA_repair0.83309146
139MP0003868_abnormal_feces_composition0.82194604
140MP0002822_catalepsy0.82121892
141MP0002229_neurodegeneration0.81630050
142MP0005332_abnormal_amino_acid0.80939678
143MP0003172_abnormal_lysosome_physiology0.80549033
144MP0001293_anophthalmia0.79566380
145MP0001186_pigmentation_phenotype0.78577367
146MP0002752_abnormal_somatic_nervous0.78309012
147MP0004924_abnormal_behavior0.77675155
148MP0005386_behavior/neurological_phenoty0.77675155
149MP0005395_other_phenotype0.77645460
150MP0003186_abnormal_redox_activity0.77174299
151MP0001663_abnormal_digestive_system0.76746572
152MP0005503_abnormal_tendon_morphology0.76630221
153MP0003698_abnormal_male_reproductive0.76474043
154MP0002095_abnormal_skin_pigmentation0.75249491
155MP0002075_abnormal_coat/hair_pigmentati0.74641837
156MP0002396_abnormal_hematopoietic_system0.74588846
157MP0005647_abnormal_sex_gland0.74337510
158MP0002398_abnormal_bone_marrow0.73740419
159MP0009333_abnormal_splenocyte_physiolog0.73689404
160MP0000372_irregular_coat_pigmentation0.72366359
161MP0005174_abnormal_tail_pigmentation0.72036248
162MP0001533_abnormal_skeleton_physiology0.70838920
163MP0001764_abnormal_homeostasis0.69475793
164MP0000767_abnormal_smooth_muscle0.68499911
165MP0003075_altered_response_to0.68361350
166MP0005390_skeleton_phenotype0.67308344
167MP0000026_abnormal_inner_ear0.66867663
168MP0005451_abnormal_body_composition0.64133272
169MP0001119_abnormal_female_reproductive0.63828763
170MP0001501_abnormal_sleep_pattern0.62220607
171MP0002177_abnormal_outer_ear0.61834049
172MP0001963_abnormal_hearing_physiology0.60690379
173MP0005084_abnormal_gallbladder_morpholo0.59016846

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)4.38751048
2Optic neuritis (HP:0100653)4.38751048
3Acute necrotizing encephalopathy (HP:0006965)4.22280376
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.14683935
5Chromsome breakage (HP:0040012)3.81720911
6Orchitis (HP:0100796)3.80165652
7Acute encephalopathy (HP:0006846)3.76367809
8Mitochondrial inheritance (HP:0001427)3.71019037
9Abnormality of midbrain morphology (HP:0002418)3.68315572
10Molar tooth sign on MRI (HP:0002419)3.68315572
11Progressive macrocephaly (HP:0004481)3.58114639
12Pendular nystagmus (HP:0012043)3.51125683
13Pancreatic cysts (HP:0001737)3.46867890
14Increased CSF lactate (HP:0002490)3.45566200
15Abnormal mitochondria in muscle tissue (HP:0008316)3.45431471
16Prostate neoplasm (HP:0100787)3.38093704
17Myositis (HP:0100614)3.38020774
18Congenital, generalized hypertrichosis (HP:0004540)3.30448338
19Pancreatic fibrosis (HP:0100732)3.28701444
20Abnormality of incisor morphology (HP:0011063)3.27555779
21Recurrent abscess formation (HP:0002722)3.21098238
22Hepatocellular necrosis (HP:0001404)3.18989476
23Nephronophthisis (HP:0000090)3.13595994
24Congenital stationary night blindness (HP:0007642)3.09181120
25Genetic anticipation (HP:0003743)3.05418147
26Abnormality of macular pigmentation (HP:0008002)3.03053670
27Recurrent pneumonia (HP:0006532)2.99426345
28Progressive cerebellar ataxia (HP:0002073)2.98914029
29Abolished electroretinogram (ERG) (HP:0000550)2.98711911
30Central scotoma (HP:0000603)2.98470148
31Eczematoid dermatitis (HP:0000976)2.96715177
32Long nose (HP:0003189)2.95880512
33Mediastinal lymphadenopathy (HP:0100721)2.91321073
34Recurrent bacterial skin infections (HP:0005406)2.84063103
35Hepatic necrosis (HP:0002605)2.81891874
36Gaze-evoked nystagmus (HP:0000640)2.80256470
37Abnormality of macrophages (HP:0004311)2.76579230
38Recurrent cutaneous fungal infections (HP:0011370)2.75170622
39Chronic mucocutaneous candidiasis (HP:0002728)2.75170622
40Lipid accumulation in hepatocytes (HP:0006561)2.72641080
413-Methylglutaconic aciduria (HP:0003535)2.72180508
42Increased hepatocellular lipid droplets (HP:0006565)2.70236698
43Recurrent gram-negative bacterial infections (HP:0005420)2.70181395
44Attenuation of retinal blood vessels (HP:0007843)2.67509745
45Abnormality of the renal medulla (HP:0100957)2.60672912
46Febrile seizures (HP:0002373)2.60548709
47Septo-optic dysplasia (HP:0100842)2.57852462
48Keratoconjunctivitis (HP:0001096)2.57452653
49Constricted visual fields (HP:0001133)2.56609289
50Cerebral edema (HP:0002181)2.53311223
51Vacuolated lymphocytes (HP:0001922)2.52652535
52White forelock (HP:0002211)2.50524846
53Flat capital femoral epiphysis (HP:0003370)2.49542650
54Decreased electroretinogram (ERG) amplitude (HP:0000654)2.45587461
55Keratoconjunctivitis sicca (HP:0001097)2.45547038
56Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.44525089
57Action tremor (HP:0002345)2.43511262
58Large for gestational age (HP:0001520)2.42924423
59Xerostomia (HP:0000217)2.40736698
60Optic disc pallor (HP:0000543)2.40344258
61Patchy hypopigmentation of hair (HP:0011365)2.35241908
62Sclerocornea (HP:0000647)2.34790827
63Congenital sensorineural hearing impairment (HP:0008527)2.34543983
64Dialeptic seizures (HP:0011146)2.34526453
65Bilateral microphthalmos (HP:0007633)2.31105357
66Epiphyseal dysplasia (HP:0002656)2.31100018
67Optic nerve hypoplasia (HP:0000609)2.29903724
68Severe visual impairment (HP:0001141)2.29250319
69Scotoma (HP:0000575)2.28816268
70Obstructive lung disease (HP:0006536)2.28512626
71Chronic obstructive pulmonary disease (HP:0006510)2.28512626
72Abnormality of the renal cortex (HP:0011035)2.27041599
73Absence seizures (HP:0002121)2.24582701
74Aplasia cutis congenita (HP:0001057)2.19265524
75Abnormal hair whorl (HP:0010721)2.18047241
76Abnormal number of erythroid precursors (HP:0012131)2.17542367
77Alveolar cell carcinoma (HP:0006519)2.16006203
78Recurrent skin infections (HP:0001581)2.15941894
79Thyroid-stimulating hormone excess (HP:0002925)2.15669067
80Type 2 muscle fiber atrophy (HP:0003554)2.15586236
81Methylmalonic acidemia (HP:0002912)2.15416867
82Furrowed tongue (HP:0000221)2.14953515
83Renal Fanconi syndrome (HP:0001994)2.14719109
84Volvulus (HP:0002580)2.14707745
85Tubular atrophy (HP:0000092)2.14005931
86Cystic liver disease (HP:0006706)2.13436916
87Recurrent fungal infections (HP:0002841)2.12799920
88Recurrent lower respiratory tract infections (HP:0002783)2.10333138
89Basal ganglia calcification (HP:0002135)2.08948532
90Hypergonadotropic hypogonadism (HP:0000815)2.08843717
91Male pseudohermaphroditism (HP:0000037)2.08533745
92Increased corneal curvature (HP:0100692)2.07644565
93Keratoconus (HP:0000563)2.07644565
94Respiratory failure (HP:0002878)2.06288256
95Chronic diarrhea (HP:0002028)2.05476115
96Focal motor seizures (HP:0011153)2.03717600
97Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.03661686
98Hepatoblastoma (HP:0002884)2.03498050
99Systemic lupus erythematosus (HP:0002725)2.02113204
100Abnormality of vitamin B metabolism (HP:0004340)2.01901614
101Reduced antithrombin III activity (HP:0001976)2.01626869
102Methylmalonic aciduria (HP:0012120)2.01413676
103Hyperglycinuria (HP:0003108)2.01257134
104Conjugated hyperbilirubinemia (HP:0002908)2.00576032
105Clubbing of toes (HP:0100760)2.00492817
106Fair hair (HP:0002286)1.99632132
107Premature loss of primary teeth (HP:0006323)1.97843159
108Leukodystrophy (HP:0002415)1.95664570
109CNS demyelination (HP:0007305)1.95417632
110Oligodactyly (hands) (HP:0001180)1.95374209
111Intestinal atresia (HP:0011100)1.95318779
112Abnormality of cells of the erythroid lineage (HP:0012130)1.95248852
113Scrotal hypoplasia (HP:0000046)1.94388539
114Ectopic kidney (HP:0000086)1.93534073
115Abnormality of the columella (HP:0009929)1.93356071
116Abnormality of urine glucose concentration (HP:0011016)1.93194665
117Glycosuria (HP:0003076)1.93194665
118Hypoproteinemia (HP:0003075)1.93042051
119Long clavicles (HP:0000890)1.92773080
120Inability to walk (HP:0002540)1.92760729
121Abnormality of the vitamin B12 metabolism (HP:0004341)1.92614306
122Tetany (HP:0001281)1.91815327
123Abnormal ciliary motility (HP:0012262)1.90856813
124Abnormality of the phalanges of the hallux (HP:0010057)1.90760700
125Aplasia/Hypoplasia of the uvula (HP:0010293)1.90366980
126Vasculitis (HP:0002633)1.88854488
127Lactic acidosis (HP:0003128)1.88846324
128Exertional dyspnea (HP:0002875)1.88237523
129Anencephaly (HP:0002323)1.87967041
130Arthropathy (HP:0003040)1.87621649
131Abnormal respiratory motile cilium physiology (HP:0012261)1.87441140
132Widely patent fontanelles and sutures (HP:0004492)1.87177461
133Conical tooth (HP:0000698)1.87064084
134True hermaphroditism (HP:0010459)1.86516624
135Increased serum lactate (HP:0002151)1.86140675
136Gingivitis (HP:0000230)1.85921346
137Focal seizures (HP:0007359)1.85754611
138Prolonged neonatal jaundice (HP:0006579)1.85503931
139Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.85470140
140Hypoplasia of the fovea (HP:0007750)1.85367703
141Aplasia/Hypoplasia of the fovea (HP:0008060)1.85367703
142Pancreatic islet-cell hyperplasia (HP:0004510)1.85297914
143Stenosis of the external auditory canal (HP:0000402)1.85109238
144Stomatitis (HP:0010280)1.85018601
145Metaphyseal dysplasia (HP:0100255)1.84338871
146Proximal tubulopathy (HP:0000114)1.83893604
147Abnormality of the hepatic vasculature (HP:0006707)1.83695760
148Abnormality of renal resorption (HP:0011038)1.83462349
149Lethargy (HP:0001254)1.82671346
150Bony spicule pigmentary retinopathy (HP:0007737)1.81903037
151Abnormality of the ileum (HP:0001549)1.81214989
152Macrocytic anemia (HP:0001972)1.81179575
153Meningitis (HP:0001287)1.80236024
154Dynein arm defect of respiratory motile cilia (HP:0012255)1.79836996
155Absent/shortened dynein arms (HP:0200106)1.79836996
156Hypoplasia of the pons (HP:0012110)1.79769917
157Meckel diverticulum (HP:0002245)1.79516324
158Abnormality of the incisor (HP:0000676)1.78462959
159Abnormality of the fovea (HP:0000493)1.78279945
160Midline defect of the nose (HP:0004122)1.78108097
161Rib fusion (HP:0000902)1.77365048
162Hypothermia (HP:0002045)1.77086631
163Chronic hepatic failure (HP:0100626)1.76968303
164Abnormality of the pons (HP:0007361)1.76788630
165Abnormality of alanine metabolism (HP:0010916)1.76519891
166Hyperalaninemia (HP:0003348)1.76519891
167Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.76519891
168Abnormality of the labia minora (HP:0012880)1.76334171
169Autoimmune thrombocytopenia (HP:0001973)1.75213234
170Azoospermia (HP:0000027)1.73053574
171Abnormality of DNA repair (HP:0003254)1.72711146
172Abnormality of chromosome stability (HP:0003220)1.72566169
173Dry hair (HP:0011359)1.72097829
174Hyperventilation (HP:0002883)1.70322774
175Abnormality of the preputium (HP:0100587)1.69628160
176Protruding tongue (HP:0010808)1.69169785
177Metaphyseal irregularity (HP:0003025)1.68877715
178Abnormality of the prostate (HP:0008775)1.68253446
179Abnormality of the femoral head (HP:0003368)1.68098716
180Neoplasm of the tracheobronchial system (HP:0100552)1.67895420
181Mesomelia (HP:0003027)1.66671957
182Abnormality of primary teeth (HP:0006481)1.64845802
183Encephalitis (HP:0002383)1.64821857
184Abnormality of the parietal bone (HP:0002696)1.63887204
185Neonatal hypoglycemia (HP:0001998)1.62820351
186Vitreoretinal degeneration (HP:0000655)1.61888997
187Generalized hypopigmentation of hair (HP:0011358)1.61687515
188Abnormality of the metopic suture (HP:0005556)1.61214147
189Cheilitis (HP:0100825)1.60565125
190Hemoptysis (HP:0002105)1.59706382
191Pulmonary infiltrates (HP:0002113)1.58343176
192Increased IgM level (HP:0003496)1.58273887

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.91166142
2IRAK33.82503140
3CASK3.81258885
4CDK193.50016290
5OXSR12.83464080
6ACVR1B2.79906289
7TXK2.63822298
8INSRR2.54111291
9VRK22.42243615
10IRAK42.21634437
11BMPR22.16383714
12PRPF4B2.14588266
13EIF2AK22.05375694
14PBK2.03044297
15TLK11.98029824
16GRK71.97436634
17STK241.96594850
18NUAK11.95338664
19PIK3CG1.94908342
20CDC71.94237464
21NTRK31.89728884
22MUSK1.85710163
23AKT31.82407936
24FRK1.76317163
25STK38L1.76217958
26WNK31.74168420
27ADRBK21.71884960
28SGK21.69487973
29ERBB31.68878623
30IKBKB1.67499453
31TAF11.64111317
32VRK11.60517161
33WNK41.58302529
34SIK31.54062656
35GRK11.53067125
36RIPK41.51035469
37STK161.47315290
38MAP2K71.45387807
39DYRK21.45100249
40ZAK1.45063527
41MAP3K131.44228161
42YES11.44020110
43MAP3K31.40751378
44BRSK21.39525315
45TEC1.30764000
46BMPR1B1.29674166
47CDK81.28037270
48CAMKK21.27937512
49TIE11.26052037
50EIF2AK31.25655423
51CHUK1.24327395
52ADRBK11.23130595
53BLK1.21404051
54MST41.20317255
55IKBKE1.20189562
56MAPK71.19635574
57TGFBR21.19230357
58PASK1.17080561
59ERBB41.10458386
60PRKCG1.10059122
61NME11.08854874
62STK391.08629147
63KIT1.08283237
64PDK21.04048985
65TBK11.01892434
66CDK31.01474027
67MAP2K61.00809302
68PIM20.99891529
69PLK40.95805032
70MAP3K120.95408958
71TYK20.93993856
72NEK60.93705469
73MAPK130.93253655
74MAPK150.92452043
75PLK30.90425534
76TGFBR10.86734205
77EPHA40.85766255
78STK30.84964697
79MKNK10.84847319
80CHEK20.81152674
81SGK30.81081633
82PLK20.80976525
83LATS10.80198263
84SGK4940.79073122
85SGK2230.79073122
86PIM10.77976991
87JAK10.77968692
88LYN0.74311068
89PRKCE0.74227535
90JAK30.73752709
91PRKG20.72314667
92TAOK20.72256036
93NTRK20.71621808
94PNCK0.70051078
95PTK2B0.69853022
96BUB10.69618718
97MAP4K20.69201739
98TRIM280.68789903
99CCNB10.67466288
100EIF2AK10.67386263
101SYK0.63027579
102NLK0.62716995
103BTK0.60423512
104CAMK2A0.57784394
105BCR0.57671543
106TNK20.57603621
107EPHA30.57373046
108PIK3CA0.57251974
109CSF1R0.54624331
110GRK50.54060519
111SGK10.53679098
112FGFR20.52830496
113LMTK20.52612544
114STK40.52005153
115HCK0.50863537
116CLK10.50799591
117MAP3K40.49735759
118PLK10.47303549
119MAPKAPK30.47214169
120CSNK1A10.47122086
121MKNK20.46875376
122PRKACA0.46284018
123NEK20.46097970
124TRPM70.45481014
125STK110.44257362
126PRKCD0.43142867
127DYRK30.40516102
128PRKCQ0.40511532
129OBSCN0.40389567
130IRAK10.40321280
131BCKDK0.37858538
132BRD40.37727488
133PRKG10.36872167
134CSNK2A10.36715941
135ITK0.36013997
136PINK10.36012757
137TAOK30.35587582
138IGF1R0.35418093
139SRPK10.35373103
140TNIK0.34789216
141MATK0.34285446
142KDR0.34142401
143PAK30.33984096
144MAPKAPK50.33977473
145PRKACB0.32732042
146LCK0.32331559
147MAPK120.31714174
148RPS6KA50.31110408
149PKN10.31018252
150FES0.29122409
151MAP3K110.28320017
152MAPK110.27634611
153FGFR30.26533379
154PRKCA0.26487597
155DAPK30.26448400
156PRKAA20.25005463
157DAPK20.24384325

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.05638743
2Parkinsons disease_Homo sapiens_hsa050123.20495838
3Ribosome_Homo sapiens_hsa030103.04036971
4Allograft rejection_Homo sapiens_hsa053302.77085918
5RNA polymerase_Homo sapiens_hsa030202.76496773
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.67253211
7Graft-versus-host disease_Homo sapiens_hsa053322.66191565
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.63170923
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.54660173
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.46923331
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.45971736
12Type I diabetes mellitus_Homo sapiens_hsa049402.45693991
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.42326742
14NF-kappa B signaling pathway_Homo sapiens_hsa040642.41328593
15Linoleic acid metabolism_Homo sapiens_hsa005912.37476392
16Leishmaniasis_Homo sapiens_hsa051402.33611015
17Rheumatoid arthritis_Homo sapiens_hsa053232.32258009
18Alzheimers disease_Homo sapiens_hsa050102.26700644
19Huntingtons disease_Homo sapiens_hsa050162.22260561
20Autoimmune thyroid disease_Homo sapiens_hsa053202.17349945
21Toll-like receptor signaling pathway_Homo sapiens_hsa046202.14709932
22Proteasome_Homo sapiens_hsa030502.06977224
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.98816514
24Protein export_Homo sapiens_hsa030601.97366868
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.96619524
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.93370559
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.91231878
28Tryptophan metabolism_Homo sapiens_hsa003801.89700329
29Cardiac muscle contraction_Homo sapiens_hsa042601.88746033
30Legionellosis_Homo sapiens_hsa051341.86939875
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.85598537
32Phototransduction_Homo sapiens_hsa047441.84729434
33Vitamin digestion and absorption_Homo sapiens_hsa049771.77315881
34Hematopoietic cell lineage_Homo sapiens_hsa046401.71756477
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.66163944
36Asthma_Homo sapiens_hsa053101.65807789
37Tuberculosis_Homo sapiens_hsa051521.65614665
38Butanoate metabolism_Homo sapiens_hsa006501.62675997
39Measles_Homo sapiens_hsa051621.58582229
40Pertussis_Homo sapiens_hsa051331.57629139
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.56245052
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54877370
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.54433312
44Malaria_Homo sapiens_hsa051441.50147634
45Other glycan degradation_Homo sapiens_hsa005111.48914184
46TNF signaling pathway_Homo sapiens_hsa046681.45978804
47Selenocompound metabolism_Homo sapiens_hsa004501.44039947
48Chemical carcinogenesis_Homo sapiens_hsa052041.37603588
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36837336
50Collecting duct acid secretion_Homo sapiens_hsa049661.35937067
51Caffeine metabolism_Homo sapiens_hsa002321.34985818
52Phagosome_Homo sapiens_hsa041451.34755166
53African trypanosomiasis_Homo sapiens_hsa051431.34563634
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.33510130
55Osteoclast differentiation_Homo sapiens_hsa043801.32619312
56Influenza A_Homo sapiens_hsa051641.31801092
57Pentose and glucuronate interconversions_Homo sapiens_hsa000401.31754938
58Staphylococcus aureus infection_Homo sapiens_hsa051501.29259911
59Fat digestion and absorption_Homo sapiens_hsa049751.20910057
60Herpes simplex infection_Homo sapiens_hsa051681.20713256
61Homologous recombination_Homo sapiens_hsa034401.19585243
62Fanconi anemia pathway_Homo sapiens_hsa034601.19131324
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.17579213
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16910987
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15787899
66Sphingolipid metabolism_Homo sapiens_hsa006001.15114120
67Jak-STAT signaling pathway_Homo sapiens_hsa046301.14562297
68SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13652563
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.13394490
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11148253
71Nitrogen metabolism_Homo sapiens_hsa009101.09517714
72Propanoate metabolism_Homo sapiens_hsa006401.07804593
73Arachidonic acid metabolism_Homo sapiens_hsa005901.02568281
74Purine metabolism_Homo sapiens_hsa002300.97220643
75Basal transcription factors_Homo sapiens_hsa030220.95764737
76Mineral absorption_Homo sapiens_hsa049780.93876434
77Mismatch repair_Homo sapiens_hsa034300.92584755
78Salmonella infection_Homo sapiens_hsa051320.92055369
79Taste transduction_Homo sapiens_hsa047420.90485060
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90450652
81Primary immunodeficiency_Homo sapiens_hsa053400.87267718
82Chemokine signaling pathway_Homo sapiens_hsa040620.86788753
83Nicotine addiction_Homo sapiens_hsa050330.85511956
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83006024
85Glutathione metabolism_Homo sapiens_hsa004800.82808826
86Pyrimidine metabolism_Homo sapiens_hsa002400.82662383
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82477962
88Fatty acid degradation_Homo sapiens_hsa000710.81231504
89Ovarian steroidogenesis_Homo sapiens_hsa049130.79475916
90Metabolic pathways_Homo sapiens_hsa011000.77876070
91Olfactory transduction_Homo sapiens_hsa047400.75975065
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75915050
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74860657
94Hepatitis C_Homo sapiens_hsa051600.74387018
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73158610
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70633362
97Toxoplasmosis_Homo sapiens_hsa051450.70355774
98Lysosome_Homo sapiens_hsa041420.66614112
99Nucleotide excision repair_Homo sapiens_hsa034200.66614045
100One carbon pool by folate_Homo sapiens_hsa006700.66407408
101Morphine addiction_Homo sapiens_hsa050320.65461750
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64901890
103Ether lipid metabolism_Homo sapiens_hsa005650.64072910
104Inositol phosphate metabolism_Homo sapiens_hsa005620.64055351
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61717854
106Melanoma_Homo sapiens_hsa052180.61032710
107Apoptosis_Homo sapiens_hsa042100.60886957
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.59452218
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58104634
110Hepatitis B_Homo sapiens_hsa051610.58098225
111Glutamatergic synapse_Homo sapiens_hsa047240.57816202
112Serotonergic synapse_Homo sapiens_hsa047260.57672311
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.57038731
114Calcium signaling pathway_Homo sapiens_hsa040200.56137239
115Peroxisome_Homo sapiens_hsa041460.55506239
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54973925
117Renin-angiotensin system_Homo sapiens_hsa046140.52713731
118B cell receptor signaling pathway_Homo sapiens_hsa046620.52231320
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.48890287
120Non-homologous end-joining_Homo sapiens_hsa034500.47895867
121Vibrio cholerae infection_Homo sapiens_hsa051100.46828959
122Spliceosome_Homo sapiens_hsa030400.46624196
123Histidine metabolism_Homo sapiens_hsa003400.46072294
124Dorso-ventral axis formation_Homo sapiens_hsa043200.45804403
125Steroid biosynthesis_Homo sapiens_hsa001000.45186194
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45138250
127Insulin secretion_Homo sapiens_hsa049110.43622758
128Fatty acid metabolism_Homo sapiens_hsa012120.42642471
129DNA replication_Homo sapiens_hsa030300.42635025
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42031441
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41952023
132Circadian rhythm_Homo sapiens_hsa047100.40403568
133Starch and sucrose metabolism_Homo sapiens_hsa005000.40103623
134Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39429967
135GABAergic synapse_Homo sapiens_hsa047270.39087489
136RNA degradation_Homo sapiens_hsa030180.36872758
137Glycerolipid metabolism_Homo sapiens_hsa005610.36807962
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36310120
139Steroid hormone biosynthesis_Homo sapiens_hsa001400.35434450
140MAPK signaling pathway_Homo sapiens_hsa040100.34923653
141Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.34493232
142Circadian entrainment_Homo sapiens_hsa047130.33771049
143Salivary secretion_Homo sapiens_hsa049700.32890432
144Protein digestion and absorption_Homo sapiens_hsa049740.32762115
145Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.32180684
146cAMP signaling pathway_Homo sapiens_hsa040240.31656255
147PPAR signaling pathway_Homo sapiens_hsa033200.31059692
148Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30800208
149Sulfur metabolism_Homo sapiens_hsa009200.30239288
150Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30053696
151Retinol metabolism_Homo sapiens_hsa008300.29956569
152Pyruvate metabolism_Homo sapiens_hsa006200.29341884
153ABC transporters_Homo sapiens_hsa020100.28874856
154Basal cell carcinoma_Homo sapiens_hsa052170.28333716
155beta-Alanine metabolism_Homo sapiens_hsa004100.28137031
156AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.27504501
157Synaptic vesicle cycle_Homo sapiens_hsa047210.27373916
158FoxO signaling pathway_Homo sapiens_hsa040680.26748037
159Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26635585
160Arginine and proline metabolism_Homo sapiens_hsa003300.25357175

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