ADGRG5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the adhesion family of G-protein coupled receptors. Members of this family are characterized by long N-termini and multiple functional domains. They may play a role in the immune system as well as in the central nervous system. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)8.00769743
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)8.00769743
3interferon-gamma production (GO:0032609)7.48891651
4negative T cell selection (GO:0043383)6.84162926
5positive thymic T cell selection (GO:0045059)6.73081267
6negative thymic T cell selection (GO:0045060)6.62270229
7positive regulation of gamma-delta T cell activation (GO:0046645)6.52013364
8cellular response to interleukin-15 (GO:0071350)6.34031443
9antigen processing and presentation of endogenous antigen (GO:0019883)6.26124377
10response to interleukin-15 (GO:0070672)6.26024631
11positive T cell selection (GO:0043368)6.00451250
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.95807337
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.95807337
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.89443006
15T cell migration (GO:0072678)5.88513667
16regulation of gamma-delta T cell differentiation (GO:0045586)5.87498584
17regulation of B cell receptor signaling pathway (GO:0050855)5.85568482
18thymic T cell selection (GO:0045061)5.80778677
19regulation of gamma-delta T cell activation (GO:0046643)5.28671877
20leukocyte aggregation (GO:0070486)5.28515253
21regulation of isotype switching to IgG isotypes (GO:0048302)5.14015900
22positive regulation of B cell differentiation (GO:0045579)5.10341393
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.06564717
24T cell selection (GO:0045058)5.02176934
25immunoglobulin mediated immune response (GO:0016064)4.97827026
26T cell receptor signaling pathway (GO:0050852)4.97461995
27regulation of interleukin-12 biosynthetic process (GO:0045075)4.69255266
28T cell costimulation (GO:0031295)4.57208125
29lymphocyte costimulation (GO:0031294)4.48636381
30regulation of interferon-gamma-mediated signaling pathway (GO:0060334)4.46660617
31regulation of response to interferon-gamma (GO:0060330)4.44310054
32antigen receptor-mediated signaling pathway (GO:0050851)4.38491015
33B cell mediated immunity (GO:0019724)4.30711266
34detection of bacterium (GO:0016045)4.30320329
35regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.30211223
36T cell differentiation involved in immune response (GO:0002292)4.25568151
37alpha-beta T cell differentiation involved in immune response (GO:0002293)4.25568151
38alpha-beta T cell activation involved in immune response (GO:0002287)4.25568151
39regulation of T cell tolerance induction (GO:0002664)4.24646803
40modulation by symbiont of host defense response (GO:0052031)4.18473885
41modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.18473885
42modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.18473885
43positive regulation by organism of defense response of other organism involved in symbiotic interact4.18473885
44modulation by symbiont of host immune response (GO:0052553)4.18473885
45positive regulation by symbiont of host defense response (GO:0052509)4.18473885
46detection of other organism (GO:0098543)4.15534205
47cytidine metabolic process (GO:0046087)4.09880386
48cytidine catabolic process (GO:0006216)4.09880386
49cytidine deamination (GO:0009972)4.09880386
50regulation of T cell receptor signaling pathway (GO:0050856)4.01019677
51mast cell activation (GO:0045576)3.95405178
52CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.94733568
53T-helper cell differentiation (GO:0042093)3.94733568
54positive regulation of isotype switching (GO:0045830)3.94465252
55activated T cell proliferation (GO:0050798)3.92642376
56positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.91430783
57regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.89806883
58regulation of natural killer cell mediated immunity (GO:0002715)3.84096624
59regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.84096624
60tolerance induction (GO:0002507)3.82734429
61sequestering of actin monomers (GO:0042989)3.81364306
62negative regulation of leukocyte mediated immunity (GO:0002704)3.80588309
63regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.79959724
64pyrimidine ribonucleoside catabolic process (GO:0046133)3.78840568
65alpha-beta T cell differentiation (GO:0046632)3.78071606
66alpha-beta T cell activation (GO:0046631)3.77394184
67DNA deamination (GO:0045006)3.75670968
68neutrophil activation involved in immune response (GO:0002283)3.71901960
69regulation of leukocyte mediated cytotoxicity (GO:0001910)3.71612045
70negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.68368418
71B cell receptor signaling pathway (GO:0050853)3.65546540
72regulation of cell killing (GO:0031341)3.60262118
73type I interferon signaling pathway (GO:0060337)3.58914387
74cellular response to type I interferon (GO:0071357)3.58914387
75response to type I interferon (GO:0034340)3.57829061
76positive regulation of natural killer cell mediated immunity (GO:0002717)3.56959602
77positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.56959602
78mast cell activation involved in immune response (GO:0002279)3.49096963
79mast cell degranulation (GO:0043303)3.49096963
80T cell differentiation (GO:0030217)3.48358544
81leukocyte cell-cell adhesion (GO:0007159)3.48010852
82cellular extravasation (GO:0045123)3.46861978
83lymphocyte migration (GO:0072676)3.46506221
84positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.45471769
85regulation of B cell differentiation (GO:0045577)3.44818146
86positive regulation of immunoglobulin mediated immune response (GO:0002891)3.43692213
87positive regulation of B cell mediated immunity (GO:0002714)3.43692213
88T cell activation involved in immune response (GO:0002286)3.40666026
89positive regulation of cell killing (GO:0031343)3.37309340
90positive regulation of DNA recombination (GO:0045911)3.36641216
91regulation of antigen processing and presentation (GO:0002577)3.35434484
92negative regulation of T cell mediated immunity (GO:0002710)3.35192718
93macrophage activation involved in immune response (GO:0002281)3.34233000
94positive regulation of interleukin-2 production (GO:0032743)3.33772888
95regulation of T cell mediated cytotoxicity (GO:0001914)3.33485535
96regulation of type I interferon-mediated signaling pathway (GO:0060338)3.32670903
97Arp2/3 complex-mediated actin nucleation (GO:0034314)3.31349000
98response to host immune response (GO:0052572)3.31177289
99response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.31177289
100negative regulation of B cell proliferation (GO:0030889)3.30443927
101respiratory burst (GO:0045730)3.30255639
102regulation of isotype switching (GO:0045191)3.28982745
103NIK/NF-kappaB signaling (GO:0038061)3.28638049
104regulation of mast cell degranulation (GO:0043304)3.28045840
105T cell activation (GO:0042110)3.26648805
106negative regulation of T cell receptor signaling pathway (GO:0050860)3.26279366
107negative regulation of erythrocyte differentiation (GO:0045647)3.25413442
108regulation of alpha-beta T cell proliferation (GO:0046640)3.24138760
109immune response-activating cell surface receptor signaling pathway (GO:0002429)3.23559413
110positive regulation of granulocyte differentiation (GO:0030854)3.19540519
111heterotypic cell-cell adhesion (GO:0034113)3.19004606
112regulation of immunoglobulin mediated immune response (GO:0002889)3.17481447
113positive regulation of tolerance induction (GO:0002645)3.17057083
114positive regulation of defense response to virus by host (GO:0002230)3.16714612
115natural killer cell activation (GO:0030101)3.15257887
116regulation of dendritic cell antigen processing and presentation (GO:0002604)3.13269011
117negative regulation of interleukin-12 production (GO:0032695)3.13183401
118detection of external biotic stimulus (GO:0098581)3.11735033
119interferon-gamma-mediated signaling pathway (GO:0060333)3.10835129
120negative regulation of alpha-beta T cell activation (GO:0046636)3.10631151
121myeloid cell activation involved in immune response (GO:0002275)3.10395562
122JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.09913981
123regulation of B cell mediated immunity (GO:0002712)3.09786106
124antigen processing and presentation via MHC class Ib (GO:0002475)3.09746280
125negative regulation of lymphocyte mediated immunity (GO:0002707)3.09696845
126positive regulation of T-helper 1 type immune response (GO:0002827)3.09619684
127positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.09528293
128negative regulation of phagocytosis (GO:0050765)3.08793743
129response to peptidoglycan (GO:0032494)3.07520474
130regulation of myeloid leukocyte mediated immunity (GO:0002886)3.06266020
131negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.05758939
132positive regulation of T cell mediated cytotoxicity (GO:0001916)3.05175921
133defense response to protozoan (GO:0042832)3.04765941
134positive regulation of antigen processing and presentation (GO:0002579)3.04467489
135neutrophil activation (GO:0042119)3.02714581
136positive regulation of alpha-beta T cell proliferation (GO:0046641)3.02457817
137regulation of tolerance induction (GO:0002643)3.02082808
138positive regulation of humoral immune response (GO:0002922)3.01717382
139regulation of mast cell activation involved in immune response (GO:0033006)3.00160248
140response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.99830188
141response to host (GO:0075136)2.99830188
142response to host defenses (GO:0052200)2.99830188
143positive regulation of T cell activation (GO:0050870)2.97111327
144response to protozoan (GO:0001562)2.95034991
145regulation of leukocyte degranulation (GO:0043300)2.94824990
146leukocyte tethering or rolling (GO:0050901)2.94634208
147negative regulation of innate immune response (GO:0045824)2.94476290
148positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.94382630
149positive regulation of T cell differentiation (GO:0045582)2.93601473
150positive regulation of immunoglobulin production (GO:0002639)2.93543689
151leukocyte degranulation (GO:0043299)2.91162887
152adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.90610844
153regulation of interferon-beta biosynthetic process (GO:0045357)2.89270441
154positive regulation of B cell activation (GO:0050871)2.87220525
155regulation of B cell apoptotic process (GO:0002902)2.87054948
156positive regulation of interleukin-17 production (GO:0032740)2.86266901
157T-helper 1 type immune response (GO:0042088)2.85993932
158negative regulation of T-helper cell differentiation (GO:0045623)2.85030306

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.82603479
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.05285371
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.33844315
4STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.78684747
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.75585521
6FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.55959262
7RUNX_20019798_ChIP-Seq_JUKART_Human3.55562553
8STAT4_19710469_ChIP-ChIP_TH1__Mouse3.42491507
9MYC_22102868_ChIP-Seq_BL_Human3.39009909
10MYB_26560356_Chip-Seq_TH2_Human3.37622377
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.36914700
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.25257389
13IRF8_21731497_ChIP-ChIP_J774_Mouse3.16125075
14EGR1_19374776_ChIP-ChIP_THP-1_Human3.01663269
15MAF_26560356_Chip-Seq_TH1_Human2.98986493
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.83168874
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.78447089
18MYB_26560356_Chip-Seq_TH1_Human2.73566299
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.62757653
20UTX_26944678_Chip-Seq_JUKART_Human2.62489889
21E2F7_22180533_ChIP-Seq_HELA_Human2.51718531
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.50713775
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.41632658
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35484036
25VDR_21846776_ChIP-Seq_THP-1_Human2.33007882
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.21377114
27RUNX1_22412390_ChIP-Seq_EML_Mouse2.20603019
28NOTCH1_21737748_ChIP-Seq_TLL_Human2.17415075
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.06367734
30MYB_21317192_ChIP-Seq_ERMYB_Mouse2.05445206
31TCF7_22412390_ChIP-Seq_EML_Mouse2.05080866
32MAF_26560356_Chip-Seq_TH2_Human2.02164201
33GATA3_27048872_Chip-Seq_THYMUS_Human2.02024436
34KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.00665888
35SPI1_23547873_ChIP-Seq_NB4_Human2.00597299
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.93513114
37VDR_24763502_ChIP-Seq_THP-1_Human1.89840229
38SCL_19346495_ChIP-Seq_HPC-7_Human1.81100435
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79132424
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78270992
41KDM2B_26808549_Chip-Seq_DND41_Human1.76192124
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.70722704
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64629605
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64394769
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52811153
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.52676480
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50349643
48SPI1_23127762_ChIP-Seq_K562_Human1.48683943
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.48439043
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44944733
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.41486082
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.38204074
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36492144
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35852212
55PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35554651
56PU_27001747_Chip-Seq_BMDM_Mouse1.29779173
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27641337
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26101174
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.25709168
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24993257
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23947220
62BCL6_27268052_Chip-Seq_Bcells_Human1.23589739
63GATA1_22025678_ChIP-Seq_K562_Human1.22723172
64RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.22627450
65CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21311748
66GATA3_26560356_Chip-Seq_TH2_Human1.21220237
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.19210123
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18461654
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17945700
70FOXM1_23109430_ChIP-Seq_U2OS_Human1.15396396
71BCOR_27268052_Chip-Seq_Bcells_Human1.13828814
72CIITA_25753668_ChIP-Seq_RAJI_Human1.12408500
73CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11728690
74EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08958491
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08756345
76KDM2B_26808549_Chip-Seq_JURKAT_Human1.08426781
77ELF1_20517297_ChIP-Seq_JURKAT_Human1.07478936
78GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04500952
79PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02664062
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02530656
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01977844
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01873624
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01002095
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00465385
85STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99691598
86P300_27268052_Chip-Seq_Bcells_Human0.97464875
87GATA1_19941827_ChIP-Seq_MEL_Mouse0.97063867
88Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93177837
89VDR_23849224_ChIP-Seq_CD4+_Human0.93153946
90GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92277084
91CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90195933
92ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89910473
93EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89862509
94RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88230195
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87759883
96SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87409721
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86865284
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86855180
99NCOR1_26117541_ChIP-Seq_K562_Human0.86789630
100NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86470768
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85139007
102SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.80634619
103SRY_22984422_ChIP-ChIP_TESTIS_Rat0.80389836
104RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80137501
105LXR_22292898_ChIP-Seq_THP-1_Human0.79596109
106VDR_24787735_ChIP-Seq_THP-1_Human0.79372982
107GATA3_26560356_Chip-Seq_TH1_Human0.79286140
108GATA2_19941826_ChIP-Seq_K562_Human0.76962816
109HOXB4_20404135_ChIP-ChIP_EML_Mouse0.76850378
110PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74420838
111FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74242688
112GATA1_19941826_ChIP-Seq_K562_Human0.71044746
113FOXP3_21729870_ChIP-Seq_TREG_Human0.70339036
114STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.68613994
115EGR1_19032775_ChIP-ChIP_M12_Human0.68581433
116SPI1_20517297_ChIP-Seq_HL60_Human0.68076343
117CLOCK_20551151_ChIP-Seq_293T_Human0.66900919
118CTCF_27219007_Chip-Seq_ERYTHROID_Human0.65626494

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.75318680
2MP0003763_abnormal_thymus_physiology4.46472531
3MP0001835_abnormal_antigen_presentation4.42072049
4MP0000685_abnormal_immune_system3.90495677
5MP0001800_abnormal_humoral_immune3.44941048
6MP0001790_abnormal_immune_system3.21691065
7MP0005387_immune_system_phenotype3.21691065
8MP0005000_abnormal_immune_tolerance3.06040239
9MP0002723_abnormal_immune_serum2.99993275
10MP0002420_abnormal_adaptive_immunity2.97631472
11MP0001819_abnormal_immune_cell2.94603597
12MP0009785_altered_susceptibility_to2.88373052
13MP0002452_abnormal_antigen_presenting2.88051958
14MP0002398_abnormal_bone_marrow2.74093768
15MP0001873_stomach_inflammation2.71978545
16MP0002405_respiratory_system_inflammati2.70800544
17MP0005025_abnormal_response_to2.64294168
18MP0009333_abnormal_splenocyte_physiolog2.50804123
19MP0004510_myositis2.47857532
20MP0000716_abnormal_immune_system2.47288399
21MP0003724_increased_susceptibility_to2.45307389
22MP0000703_abnormal_thymus_morphology2.42920777
23MP0002166_altered_tumor_susceptibility2.42565050
24MP0003436_decreased_susceptibility_to2.40641711
25MP0002722_abnormal_immune_system2.32397600
26MP0002419_abnormal_innate_immunity2.32115441
27MP0010155_abnormal_intestine_physiology2.29873899
28MP0000689_abnormal_spleen_morphology2.16529247
29MP0002148_abnormal_hypersensitivity_rea2.11145333
30MP0002006_tumorigenesis2.09394077
31MP0004947_skin_inflammation2.06826098
32MP0001853_heart_inflammation2.05670214
33MP0002429_abnormal_blood_cell2.01309624
34MP0003866_abnormal_defecation1.94631759
35MP0003303_peritoneal_inflammation1.94421350
36MP0005464_abnormal_platelet_physiology1.91955766
37MP0002396_abnormal_hematopoietic_system1.88136973
38MP0001845_abnormal_inflammatory_respons1.84785748
39MP0002933_joint_inflammation1.84135672
40MP0003300_gastrointestinal_ulcer1.75101844
41MP0000858_altered_metastatic_potential1.71394357
42MP0006082_CNS_inflammation1.70231881
43MP0005310_abnormal_salivary_gland1.69300403
44MP0003183_abnormal_peptide_metabolism1.51623106
45MP0003448_altered_tumor_morphology1.36882630
46MP0010352_gastrointestinal_tract_polyps1.35177397
47MP0005645_abnormal_hypothalamus_physiol1.32074586
48MP0008469_abnormal_protein_level1.20741977
49MP0004808_abnormal_hematopoietic_stem1.19709985
50MP0001533_abnormal_skeleton_physiology1.19049222
51MP0002693_abnormal_pancreas_physiology1.18111213
52MP0005075_abnormal_melanosome_morpholog1.12595116
53MP0001851_eye_inflammation1.10571310
54MP0003787_abnormal_imprinting1.10416669
55MP0000465_gastrointestinal_hemorrhage1.08010451
56MP0005451_abnormal_body_composition1.06013671
57MP0003075_altered_response_to1.05410227
58MP0000490_abnormal_crypts_of1.04620893
59MP0004381_abnormal_hair_follicle1.03862668
60MP0002138_abnormal_hepatobiliary_system1.01394173
61MP0003045_fibrosis0.96642343
62MP0001545_abnormal_hematopoietic_system0.92922608
63MP0005397_hematopoietic_system_phenotyp0.92922608
64MP0002019_abnormal_tumor_incidence0.92894310
65MP0005174_abnormal_tail_pigmentation0.91616592
66MP0009764_decreased_sensitivity_to0.89230037
67MP0002998_abnormal_bone_remodeling0.87584493
68MP0005084_abnormal_gallbladder_morpholo0.86663102
69MP0002009_preneoplasia0.86642000
70MP0008961_abnormal_basal_metabolism0.85628009
71MP0003806_abnormal_nucleotide_metabolis0.83300008
72MP0001986_abnormal_taste_sensitivity0.79384761
73MP0005023_abnormal_wound_healing0.79328541
74MP0002163_abnormal_gland_morphology0.78261628
75MP0000343_altered_response_to0.77087029
76MP0009278_abnormal_bone_marrow0.75942849
77MP0002132_abnormal_respiratory_system0.74219027
78MP0005058_abnormal_lysosome_morphology0.73312465
79MP0000015_abnormal_ear_pigmentation0.72944143
80MP0008260_abnormal_autophagy0.72338014
81MP0009763_increased_sensitivity_to0.72220640
82MP0004883_abnormal_blood_vessel0.71748583
83MP0005076_abnormal_cell_differentiation0.71651248
84MP0008057_abnormal_DNA_replication0.70989675
85MP0000609_abnormal_liver_physiology0.70946204
86MP0003172_abnormal_lysosome_physiology0.69122889
87MP0009765_abnormal_xenobiotic_induced0.68821193
88MP0005319_abnormal_enzyme/_coenzyme0.67165075
89MP0008877_abnormal_DNA_methylation0.67056954
90MP0003453_abnormal_keratinocyte_physiol0.66951788
91MP0010307_abnormal_tumor_latency0.66519682
92MP0002136_abnormal_kidney_physiology0.65591669
93MP0002277_abnormal_respiratory_mucosa0.63254316
94MP0000477_abnormal_intestine_morphology0.60703819
95MP0005379_endocrine/exocrine_gland_phen0.60011745
96MP0001243_abnormal_dermal_layer0.59822665
97MP0003828_pulmonary_edema0.58800068
98MP0003690_abnormal_glial_cell0.58461165
99MP0000249_abnormal_blood_vessel0.57884890
100MP0003191_abnormal_cellular_cholesterol0.57642219
101MP0001663_abnormal_digestive_system0.56636413
102MP0003077_abnormal_cell_cycle0.56042007
103MP0008874_decreased_physiological_sensi0.55287502
104MP0005535_abnormal_body_temperature0.53283124
105MP0009642_abnormal_blood_homeostasis0.52875347
106MP0002139_abnormal_hepatobiliary_system0.51965353
107MP0003786_premature_aging0.51862969
108MP0001881_abnormal_mammary_gland0.51565722
109MP0003795_abnormal_bone_structure0.49996583
110MP0003638_abnormal_response/metabolism_0.49877139
111MP0003252_abnormal_bile_duct0.48838659
112MP0001765_abnormal_ion_homeostasis0.48817737
113MP0005220_abnormal_exocrine_pancreas0.48219589
114MP0003943_abnormal_hepatobiliary_system0.46775461
115MP0002078_abnormal_glucose_homeostasis0.46637833
116MP0000604_amyloidosis0.45900598
117MP0001216_abnormal_epidermal_layer0.45425866
118MP0005166_decreased_susceptibility_to0.44679371
119MP0008873_increased_physiological_sensi0.44115663
120MP0002928_abnormal_bile_duct0.44076140
121MP0008007_abnormal_cellular_replicative0.43961002
122MP0010234_abnormal_vibrissa_follicle0.43739327
123MP0003091_abnormal_cell_migration0.43167208
124MP0005390_skeleton_phenotype0.42846531
125MP0003693_abnormal_embryo_hatching0.42360130
126MP0004957_abnormal_blastocyst_morpholog0.40739679
127MP0000367_abnormal_coat/_hair0.39421955
128MP0003566_abnormal_cell_adhesion0.39256413

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.64802101
2Abnormality of T cell number (HP:0011839)7.23618679
3Myositis (HP:0100614)5.71133865
4Combined immunodeficiency (HP:0005387)5.46460352
5Abnormality of T cells (HP:0002843)5.34771064
6Severe combined immunodeficiency (HP:0004430)5.26035197
7Elevated erythrocyte sedimentation rate (HP:0003565)5.14510152
8IgM deficiency (HP:0002850)4.87420820
9Retrobulbar optic neuritis (HP:0100654)4.72743001
10Optic neuritis (HP:0100653)4.72743001
11Orchitis (HP:0100796)4.46791398
12Recurrent bronchitis (HP:0002837)4.45240645
13Recurrent fungal infections (HP:0002841)4.32358464
14Stomatitis (HP:0010280)4.24552406
15Nasal polyposis (HP:0100582)4.20772662
16Recurrent viral infections (HP:0004429)4.20157763
17Thyroiditis (HP:0100646)4.19370716
18Pustule (HP:0200039)4.13778179
19Abnormality of macrophages (HP:0004311)4.13413338
20Eczematoid dermatitis (HP:0000976)3.97741595
21Recurrent abscess formation (HP:0002722)3.92319248
22Panhypogammaglobulinemia (HP:0003139)3.91122127
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.81182135
24Chronic mucocutaneous candidiasis (HP:0002728)3.79141693
25Recurrent cutaneous fungal infections (HP:0011370)3.79141693
26Chronic otitis media (HP:0000389)3.75094968
27Abnormality of eosinophils (HP:0001879)3.70398673
28Chronic diarrhea (HP:0002028)3.68000107
29IgG deficiency (HP:0004315)3.64847349
30Abnormality of the nasal mucosa (HP:0000433)3.54392065
31Urticaria (HP:0001025)3.51161354
32Keratoconjunctivitis sicca (HP:0001097)3.50926884
33Inflammation of the large intestine (HP:0002037)3.43129432
34Hypochromic anemia (HP:0001931)3.41376474
35Pulmonary infiltrates (HP:0002113)3.35101762
36Abnormality of T cell physiology (HP:0011840)3.33806553
37Gastrointestinal inflammation (HP:0004386)3.31044082
38Meningitis (HP:0001287)3.29904836
39Recurrent bacterial skin infections (HP:0005406)3.28153741
40Gastrointestinal stroma tumor (HP:0100723)3.26953749
41Encephalitis (HP:0002383)3.25875321
42Leukocytosis (HP:0001974)3.22576895
43Abnormality of the fingertips (HP:0001211)3.21377452
44Recurrent skin infections (HP:0001581)3.15971116
45Keratoconjunctivitis (HP:0001096)3.15894704
46Autoimmune thrombocytopenia (HP:0001973)3.12949521
47Spontaneous hematomas (HP:0007420)3.10976219
48Hemoptysis (HP:0002105)3.08003135
49Joint swelling (HP:0001386)2.98218220
50Vasculitis (HP:0002633)2.97453097
51Increased density of long bones (HP:0006392)2.97352606
52Arterial thrombosis (HP:0004420)2.86358442
53Lymphopenia (HP:0001888)2.86264190
54Mediastinal lymphadenopathy (HP:0100721)2.85044893
55Autoimmune hemolytic anemia (HP:0001890)2.84769552
56Gastrointestinal infarctions (HP:0005244)2.83969512
57Agammaglobulinemia (HP:0004432)2.82300169
58Eosinophilia (HP:0001880)2.79917623
59Chronic obstructive pulmonary disease (HP:0006510)2.79236768
60Obstructive lung disease (HP:0006536)2.79236768
61Recurrent sinusitis (HP:0011108)2.75988676
62Osteomyelitis (HP:0002754)2.75950806
63Abnormality of cells of the lymphoid lineage (HP:0012140)2.72077980
64IgA deficiency (HP:0002720)2.68294856
65Increased IgM level (HP:0003496)2.67634976
66Colitis (HP:0002583)2.62903990
67Sepsis (HP:0100806)2.61807718
68Increased IgE level (HP:0003212)2.61670172
69Abnormality of B cell number (HP:0010975)2.61637302
70B lymphocytopenia (HP:0010976)2.61637302
71Pulmonary embolism (HP:0002204)2.54323712
72Granulocytopenia (HP:0001913)2.44813895
73Abnormality of the prostate (HP:0008775)2.43156259
74Bronchitis (HP:0012387)2.41553192
75Prolonged bleeding time (HP:0003010)2.37016264
76Lymphoma (HP:0002665)2.32359658
77Hypergammaglobulinemia (HP:0010702)2.31222017
78Epistaxis (HP:0000421)2.30463737
79Acute hepatic failure (HP:0006554)2.29298315
80Gingivitis (HP:0000230)2.24358600
81Recurrent lower respiratory tract infections (HP:0002783)2.24340803
82Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.23324259
83Skin rash (HP:0000988)2.21746619
84Hematochezia (HP:0002573)2.21597193
85Viral hepatitis (HP:0006562)2.21340407
86Anorexia (HP:0002039)2.20992700
87Petechiae (HP:0000967)2.20673921
88Papilloma (HP:0012740)2.19765077
89Verrucae (HP:0200043)2.19765077
90Neonatal hypoglycemia (HP:0001998)2.17618157
91Hypochromic microcytic anemia (HP:0004840)2.14545970
92Thrombocytosis (HP:0001894)2.13488014
93Gangrene (HP:0100758)2.12821813
94Gingival bleeding (HP:0000225)2.12774906
95Persistence of primary teeth (HP:0006335)2.11960412
96Recurrent pneumonia (HP:0006532)2.11029313
97Hypoplasia of the thymus (HP:0000778)2.10311461
98Restrictive lung disease (HP:0002091)2.08883969
99Abnormal platelet volume (HP:0011876)2.01842836
100Neutropenia (HP:0001875)2.01783861
101Chest pain (HP:0100749)2.00625345
102Basal cell carcinoma (HP:0002671)1.98596607
103Frequent falls (HP:0002359)1.97360953
104Interstitial pulmonary disease (HP:0006530)1.96798415
105Spondylolisthesis (HP:0003302)1.94838760
106Aplasia/Hypoplasia of the thymus (HP:0010515)1.94534516
107Recurrent otitis media (HP:0000403)1.93372721
108Increased CSF protein (HP:0002922)1.92564857
109Skin ulcer (HP:0200042)1.91329719
110Recurrent gram-negative bacterial infections (HP:0005420)1.90187531
111Episodic fever (HP:0001954)1.89112833
112Microcytic anemia (HP:0001935)1.88330228
113Polyneuropathy (HP:0001271)1.84973558
114Abnormality of the pleura (HP:0002103)1.83903181
115Abnormality of the endocardium (HP:0004306)1.83454682
116Cellulitis (HP:0100658)1.82446934
117Periodontitis (HP:0000704)1.81953493
118Cheilitis (HP:0100825)1.80460098
119Bronchiectasis (HP:0002110)1.78800120
120Arthralgia (HP:0002829)1.78365570
121Keratitis (HP:0000491)1.77317965

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.96201300
2MAP4K15.81846558
3ZAP703.20182826
4ITK3.18751650
5JAK32.68829364
6GRK62.62277019
7STK102.52209046
8JAK12.43125244
9TYK22.37439701
10BLK2.24126540
11IKBKE2.20158859
12FGFR42.15879218
13MAP3K142.15082744
14PRPF4B2.10043117
15TLK12.08330473
16TESK22.06839588
17MAP3K132.00034909
18EEF2K1.81726654
19TAOK31.79628220
20TBK11.76978074
21CSK1.72612687
22MAP3K121.72466404
23NLK1.69669613
24LCK1.63829180
25TEC1.57338872
26FGFR31.57220712
27CDK191.56667868
28SYK1.54214482
29BTK1.47974314
30MST41.40214775
31MAP3K101.39036394
32KDR1.36952055
33MAP3K111.36410684
34IKBKB1.35343552
35IRAK31.34593006
36IRAK41.31906461
37HCK1.30445415
38KIT1.25227301
39PIK3CA1.18458725
40EPHB11.08848571
41PIM11.06433599
42MAPK121.00949879
43LRRK21.00838457
44PKN21.00630381
45MARK31.00244972
46STK240.99493481
47SIK20.98811516
48SMG10.98205781
49TGFBR20.97096494
50CDC42BPA0.94276310
51PRKCH0.92304501
52CHUK0.90311048
53MATK0.89913684
54CSF1R0.89772273
55PRKCQ0.86090751
56LYN0.85155457
57CLK10.81391757
58TSSK60.81127749
59MAP3K10.76376083
60FES0.75587745
61PIK3CG0.74214461
62JAK20.73609551
63RPS6KA40.72906404
64FLT30.70829323
65TNK20.69124314
66MAP2K30.64307259
67PDGFRB0.64005091
68PASK0.63324563
69MAP3K70.63209721
70RET0.62875421
71CDK40.62276448
72MAP3K30.61818526
73SIK30.61301923
74EPHA30.60582230
75PDPK10.59435227
76TRIB30.58829794
77MELK0.58467307
78GRK70.58413225
79TESK10.57073053
80FRK0.56478136
81MAP3K50.54559367
82BCKDK0.54454894
83FGFR10.53453090
84CDK120.52843964
85YES10.51580738
86MAPK70.49693282
87PRKD20.49091245
88CAMKK20.48786511
89DMPK0.47154356
90EIF2AK10.45231200
91FYN0.44387182
92OXSR10.44087766
93PDK10.42813646
94MAP3K60.41453640
95ALK0.40212572
96PTK2B0.39582270
97ERN10.39485464
98BMPR20.39452641
99RPS6KB20.38641359
100TTN0.37173233
101MARK20.37120246
102TAOK10.36986673
103HIPK20.36454925
104SIK10.35861222
105INSR0.34415443
106MAPKAPK20.34360994
107PAK40.33375265
108CAMKK10.33192097
109MAP2K60.32731376
110IRAK10.32574722
111MAPK150.31473358
112TRPM70.30897483
113NME20.30547825
114MYLK0.29874748
115STK110.29680777
116FGR0.29650376
117MAP3K80.28270205
118STK40.27582353
119EIF2AK30.26581415
120DAPK20.26101182
121MAPKAPK30.24582192
122ABL10.24528986
123CDK90.24132663
124SCYL20.23659952
125IGF1R0.23496602
126MAP2K20.22943054
127MAPK110.21852779
128PTK60.20744994
129TYRO30.20728566
130PRKD10.20348485
131PRKCD0.20261784
132RIPK40.19355120

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.04652904
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.74736173
3T cell receptor signaling pathway_Homo sapiens_hsa046603.71854903
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.34638969
5Antigen processing and presentation_Homo sapiens_hsa046123.33270123
6Graft-versus-host disease_Homo sapiens_hsa053323.02919216
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.83458165
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.71820546
9Measles_Homo sapiens_hsa051622.68112250
10Osteoclast differentiation_Homo sapiens_hsa043802.44780670
11Leishmaniasis_Homo sapiens_hsa051402.36630427
12B cell receptor signaling pathway_Homo sapiens_hsa046622.18409197
13Hematopoietic cell lineage_Homo sapiens_hsa046402.12345155
14Allograft rejection_Homo sapiens_hsa053302.06981904
15Jak-STAT signaling pathway_Homo sapiens_hsa046301.96667445
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.64002457
17Chemokine signaling pathway_Homo sapiens_hsa040621.58564216
18Herpes simplex infection_Homo sapiens_hsa051681.57225544
19Leukocyte transendothelial migration_Homo sapiens_hsa046701.56441848
20Toxoplasmosis_Homo sapiens_hsa051451.55796050
21Viral myocarditis_Homo sapiens_hsa054161.54179914
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.50271199
23Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.40027089
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39268462
25Acute myeloid leukemia_Homo sapiens_hsa052211.38946609
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.38394153
27Apoptosis_Homo sapiens_hsa042101.36195812
28Staphylococcus aureus infection_Homo sapiens_hsa051501.30345832
29TNF signaling pathway_Homo sapiens_hsa046681.27804310
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26763740
31Influenza A_Homo sapiens_hsa051641.22552332
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21023556
33Shigellosis_Homo sapiens_hsa051311.20358565
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.19580634
35Hepatitis B_Homo sapiens_hsa051611.13601928
36Pancreatic cancer_Homo sapiens_hsa052121.11884794
37VEGF signaling pathway_Homo sapiens_hsa043701.05044738
38Platelet activation_Homo sapiens_hsa046111.02254070
39HTLV-I infection_Homo sapiens_hsa051661.01946313
40Autoimmune thyroid disease_Homo sapiens_hsa053201.00070764
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99627234
42Colorectal cancer_Homo sapiens_hsa052100.98964431
43Epstein-Barr virus infection_Homo sapiens_hsa051690.95473639
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94863713
45Malaria_Homo sapiens_hsa051440.90075777
46Tuberculosis_Homo sapiens_hsa051520.89381194
47Legionellosis_Homo sapiens_hsa051340.87718197
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87034628
49Chronic myeloid leukemia_Homo sapiens_hsa052200.84131553
50Salmonella infection_Homo sapiens_hsa051320.83886938
51Prolactin signaling pathway_Homo sapiens_hsa049170.81107369
52Systemic lupus erythematosus_Homo sapiens_hsa053220.80956356
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80181231
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.76646007
55Type I diabetes mellitus_Homo sapiens_hsa049400.75956710
56Phagosome_Homo sapiens_hsa041450.75523763
57Hepatitis C_Homo sapiens_hsa051600.75132323
58Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74023818
59Viral carcinogenesis_Homo sapiens_hsa052030.71889445
60p53 signaling pathway_Homo sapiens_hsa041150.67778171
61Pertussis_Homo sapiens_hsa051330.64898049
62Endocytosis_Homo sapiens_hsa041440.63435017
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61404972
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61294271
65Asthma_Homo sapiens_hsa053100.60517748
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60131790
67Non-small cell lung cancer_Homo sapiens_hsa052230.59888029
68Rheumatoid arthritis_Homo sapiens_hsa053230.53394800
69Notch signaling pathway_Homo sapiens_hsa043300.51982438
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51412058
71Small cell lung cancer_Homo sapiens_hsa052220.49753890
72Other glycan degradation_Homo sapiens_hsa005110.49065490
73Ribosome_Homo sapiens_hsa030100.48907737
74FoxO signaling pathway_Homo sapiens_hsa040680.48596364
75Spliceosome_Homo sapiens_hsa030400.46686539
76Insulin resistance_Homo sapiens_hsa049310.44464754
77MAPK signaling pathway_Homo sapiens_hsa040100.44371043
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42558671
79Circadian rhythm_Homo sapiens_hsa047100.42246390
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42000917
81Thyroid cancer_Homo sapiens_hsa052160.39206720
82Lysosome_Homo sapiens_hsa041420.38409847
83mTOR signaling pathway_Homo sapiens_hsa041500.38132446
84Caffeine metabolism_Homo sapiens_hsa002320.37308117
85Rap1 signaling pathway_Homo sapiens_hsa040150.34825627
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34706261
87HIF-1 signaling pathway_Homo sapiens_hsa040660.33428673
88Pentose phosphate pathway_Homo sapiens_hsa000300.33347941
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.32800270
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.32712368
91Endometrial cancer_Homo sapiens_hsa052130.32212654
92African trypanosomiasis_Homo sapiens_hsa051430.31735535
93Inositol phosphate metabolism_Homo sapiens_hsa005620.31685523
94RNA degradation_Homo sapiens_hsa030180.30900748
95Type II diabetes mellitus_Homo sapiens_hsa049300.30086124
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.29757871
97Non-homologous end-joining_Homo sapiens_hsa034500.29328463
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.28152521
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28020073
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.25190791
101Prostate cancer_Homo sapiens_hsa052150.24435498
102Renal cell carcinoma_Homo sapiens_hsa052110.24411731
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23830016
104Adherens junction_Homo sapiens_hsa045200.23505364
105Base excision repair_Homo sapiens_hsa034100.21834949
106Focal adhesion_Homo sapiens_hsa045100.21448543
107MicroRNAs in cancer_Homo sapiens_hsa052060.20212050
108Pathways in cancer_Homo sapiens_hsa052000.19701910
109Choline metabolism in cancer_Homo sapiens_hsa052310.19421290
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19290071
111Regulation of autophagy_Homo sapiens_hsa041400.18814269
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.17691901
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.16921986
114Arachidonic acid metabolism_Homo sapiens_hsa005900.15491811
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13725908
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.12841063
117Renin-angiotensin system_Homo sapiens_hsa046140.10314832
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.05746148
119Ras signaling pathway_Homo sapiens_hsa040140.03705519
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.03602056

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »