ADGRG6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene, which is upregulated in human umbilical vein endothelial cells, encodes a G protein-coupled receptor. Variations in this gene can affect a person's stature. Multiple transcript variants encoding different proteins have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of fibrinolysis (GO:0051918)6.78762406
2very-low-density lipoprotein particle assembly (GO:0034379)6.06851854
3regulation of fibrinolysis (GO:0051917)5.81828855
4regulation of protein activation cascade (GO:2000257)5.71098099
5regulation of complement activation (GO:0030449)5.57312922
6protein carboxylation (GO:0018214)5.18958635
7peptidyl-glutamic acid carboxylation (GO:0017187)5.18958635
8plasma lipoprotein particle assembly (GO:0034377)5.13311684
9inflammatory response to antigenic stimulus (GO:0002437)4.87572724
10intestinal cholesterol absorption (GO:0030299)4.76297351
11L-phenylalanine metabolic process (GO:0006558)4.70960370
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.70960370
13protein-lipid complex assembly (GO:0065005)4.53418982
14regulation of plasminogen activation (GO:0010755)4.42730918
15blood coagulation, intrinsic pathway (GO:0007597)4.40822853
16negative regulation of protein activation cascade (GO:2000258)4.40809577
17L-phenylalanine catabolic process (GO:0006559)4.38110984
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.38110984
19low-density lipoprotein particle remodeling (GO:0034374)4.32977496
20regulation of apoptotic cell clearance (GO:2000425)4.20126811
21cholesterol efflux (GO:0033344)4.05426806
22positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.03433460
23complement activation, alternative pathway (GO:0006957)4.02805193
24production of molecular mediator involved in inflammatory response (GO:0002532)3.95873053
25fibrinolysis (GO:0042730)3.86548958
26growth hormone receptor signaling pathway (GO:0060396)3.85221693
27regulation of cholesterol esterification (GO:0010872)3.84258389
28Golgi transport vesicle coating (GO:0048200)3.83645681
29COPI coating of Golgi vesicle (GO:0048205)3.83645681
30plasma lipoprotein particle remodeling (GO:0034369)3.83626023
31protein-lipid complex remodeling (GO:0034368)3.83626023
32macromolecular complex remodeling (GO:0034367)3.83626023
33regulation of cholesterol homeostasis (GO:2000188)3.76545396
34endocardial cushion morphogenesis (GO:0003203)3.73734741
35plasma lipoprotein particle organization (GO:0071827)3.71797417
36regulation of T-helper 2 cell differentiation (GO:0045628)3.69251419
37detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.68388983
38negative regulation of complement activation (GO:0045916)3.68325201
39COPII vesicle coating (GO:0048208)3.61825665
40hemidesmosome assembly (GO:0031581)3.61324126
41proline biosynthetic process (GO:0006561)3.60435389
42natural killer cell mediated cytotoxicity (GO:0042267)3.56060749
43natural killer cell mediated immunity (GO:0002228)3.56060749
44hepatocyte apoptotic process (GO:0097284)3.54636308
45bundle of His cell to Purkinje myocyte communication (GO:0086069)3.52255028
46cell adhesion mediated by integrin (GO:0033627)3.50879526
47regulation of dendritic cell antigen processing and presentation (GO:0002604)3.50684379
48protein-lipid complex subunit organization (GO:0071825)3.47705293
49regulation of interleukin-8 secretion (GO:2000482)3.46419986
50regulation of cholesterol biosynthetic process (GO:0045540)3.46325687
51negative regulation of blood coagulation (GO:0030195)3.45778518
52negative regulation of hemostasis (GO:1900047)3.45778518
53regulation of bile acid biosynthetic process (GO:0070857)3.45329527
54skin morphogenesis (GO:0043589)3.38349790
55positive regulation of type 2 immune response (GO:0002830)3.37591372
56positive regulation of blood coagulation (GO:0030194)3.34427741
57positive regulation of hemostasis (GO:1900048)3.34427741
58proline metabolic process (GO:0006560)3.33625122
59desmosome organization (GO:0002934)3.33400143
60intestinal absorption (GO:0050892)3.32412008
61high-density lipoprotein particle remodeling (GO:0034375)3.32155445
62negative regulation of coagulation (GO:0050819)3.31374517
63maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.26922290
64basement membrane organization (GO:0071711)3.26118167
65drug transmembrane transport (GO:0006855)3.23555542
66cellular response to growth hormone stimulus (GO:0071378)3.21563233
67plasma lipoprotein particle clearance (GO:0034381)3.21519268
68negative regulation of wound healing (GO:0061045)3.19999111
69cellular response to vitamin D (GO:0071305)3.18938815
70negative regulation of sterol transport (GO:0032372)3.12634824
71negative regulation of cholesterol transport (GO:0032375)3.12634824
72hepatocyte differentiation (GO:0070365)3.12357275
73lipoprotein metabolic process (GO:0042157)3.11100395
74positive regulation of coagulation (GO:0050820)3.10001331
75regulation of integrin activation (GO:0033623)3.09877326
76protein retention in ER lumen (GO:0006621)3.08248085
77mesenchyme morphogenesis (GO:0072132)3.08097358
78low-density lipoprotein particle clearance (GO:0034383)3.07893179
79positive regulation of natural killer cell differentiation (GO:0032825)3.05499126
80antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.05481353
81negative regulation of fatty acid transport (GO:2000192)3.04404797
82reverse cholesterol transport (GO:0043691)3.03032322
83response to muramyl dipeptide (GO:0032495)3.02865618
84glutamate metabolic process (GO:0006536)2.99642627
85neural crest cell development (GO:0014032)2.99403005
86negative regulation of interleukin-8 production (GO:0032717)2.97885912
87dicarboxylic acid biosynthetic process (GO:0043650)2.97398025
88triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.96840539
89heart valve formation (GO:0003188)2.94845020
90lung epithelium development (GO:0060428)2.94484159
91renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.94199195
92positive regulation of T-helper cell differentiation (GO:0045624)2.90597518
93neutrophil activation involved in immune response (GO:0002283)2.88092592
94ruffle organization (GO:0031529)2.87956543
95regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.87761999
96protein activation cascade (GO:0072376)2.87218616
97mammary gland development (GO:0030879)2.87085943
98regulation of activation of Janus kinase activity (GO:0010533)2.85938010
99icosanoid secretion (GO:0032309)2.85722336
100arachidonic acid secretion (GO:0050482)2.85722336
101regulation of interleukin-12 biosynthetic process (GO:0045075)2.85672651
102gland morphogenesis (GO:0022612)2.85198292
103regulation of humoral immune response (GO:0002920)2.83489645
104NIK/NF-kappaB signaling (GO:0038061)2.82629185
105pinocytosis (GO:0006907)2.81941356
106response to fungus (GO:0009620)2.81698263
107granulocyte differentiation (GO:0030851)2.79077721
108positive regulation of hormone metabolic process (GO:0032352)2.78441824
109interleukin-6-mediated signaling pathway (GO:0070102)2.77662317
110embryonic retina morphogenesis in camera-type eye (GO:0060059)2.77498522
111cholesterol homeostasis (GO:0042632)2.73455316
112negative regulation of lipase activity (GO:0060192)2.73120439
113regulation of macrophage cytokine production (GO:0010935)2.72194832
114sterol homeostasis (GO:0055092)2.72159455
115cell proliferation involved in metanephros development (GO:0072203)2.71579586
116biotin metabolic process (GO:0006768)2.71254066
117Notch signaling involved in heart development (GO:0061314)2.70967816
118positive regulation of interleukin-12 production (GO:0032735)2.70894929
119acute-phase response (GO:0006953)2.70228337
120otic vesicle formation (GO:0030916)2.69837629
121gap junction assembly (GO:0016264)2.68598139
122positive regulation of male gonad development (GO:2000020)2.68004305
123glutamine family amino acid biosynthetic process (GO:0009084)2.67339599
124notochord development (GO:0030903)2.66868875
125negative regulation of lipid transport (GO:0032369)2.66848042
126heart valve morphogenesis (GO:0003179)2.66512722
127aorta morphogenesis (GO:0035909)2.65860346
128cellular glucuronidation (GO:0052695)2.65743311
129phospholipid efflux (GO:0033700)2.65576888
130regulation of hypersensitivity (GO:0002883)2.65215603
131negative regulation of chondrocyte differentiation (GO:0032331)2.65075100
132dendritic cell chemotaxis (GO:0002407)2.63676473
133dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.63564636
134cellular response to antibiotic (GO:0071236)2.62110825
135neuron projection extension involved in neuron projection guidance (GO:1902284)2.61729197
136axon extension involved in axon guidance (GO:0048846)2.61729197
137complement activation, classical pathway (GO:0006958)2.61231226
138positive regulation of vesicle fusion (GO:0031340)2.60515431
139regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.60169311
140urea metabolic process (GO:0019627)2.60084462
141regulation of cholesterol metabolic process (GO:0090181)2.59715390
142mesenchymal cell development (GO:0014031)2.58798563
143negative regulation of humoral immune response (GO:0002921)2.57556045
144lipoxygenase pathway (GO:0019372)2.56845773
145regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.55788740
146negative regulation by host of viral transcription (GO:0043922)2.55697583
147cholesterol transport (GO:0030301)2.55327163
148sterol transport (GO:0015918)2.55327163
149regulation of water loss via skin (GO:0033561)2.55158079
150nephron tubule formation (GO:0072079)2.54785367
151cellular response to interferon-alpha (GO:0035457)2.54687701
152positive regulation of pseudopodium assembly (GO:0031274)2.54687419
153regulation of heart morphogenesis (GO:2000826)2.53446015
1544-hydroxyproline metabolic process (GO:0019471)2.52690963
155negative regulation of sodium ion transport (GO:0010766)2.52197771
156endocardial cushion development (GO:0003197)2.51377871
157response to prostaglandin (GO:0034694)2.50894789
158positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.50330239
159hyaluronan metabolic process (GO:0030212)2.50164919
160urea cycle (GO:0000050)2.49835170
161mesodermal cell differentiation (GO:0048333)2.48279328
162epithelial cell-cell adhesion (GO:0090136)2.46908117
163positive regulation of antigen processing and presentation (GO:0002579)2.46707926
164regulation of male gonad development (GO:2000018)2.46149937
165eye photoreceptor cell differentiation (GO:0001754)2.45830038
166photoreceptor cell differentiation (GO:0046530)2.45830038
167interferon-gamma secretion (GO:0072643)2.43065324
168icosanoid transport (GO:0071715)2.42892485
169fatty acid derivative transport (GO:1901571)2.42892485
170detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.42550051
171regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.40431481
172neutrophil activation (GO:0042119)2.40004260
173cellular response to vitamin (GO:0071295)2.39599015
174cell migration involved in sprouting angiogenesis (GO:0002042)2.39319423
175antigen processing and presentation of endogenous antigen (GO:0019883)2.33864012
176vitamin catabolic process (GO:0009111)2.33689833
177fat-soluble vitamin catabolic process (GO:0042363)2.33689833
178granulocyte activation (GO:0036230)2.32669036
179positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.32317480
180positive regulation of extracellular matrix organization (GO:1903055)2.29038230
181limb bud formation (GO:0060174)2.28216726
182regulation of antigen processing and presentation (GO:0002577)2.26856801
183regulation of T-helper 1 cell differentiation (GO:0045625)2.26747613
184stem cell development (GO:0048864)2.22952561
185negative regulation of keratinocyte proliferation (GO:0010839)2.22740300
186prostaglandin biosynthetic process (GO:0001516)2.21811824
187prostanoid biosynthetic process (GO:0046457)2.21811824
188dendritic cell migration (GO:0036336)2.21466797
189positive regulation of T cell cytokine production (GO:0002726)2.20916964
190T-helper 1 type immune response (GO:0042088)2.20390115
191keratinocyte differentiation (GO:0030216)2.20319339
192negative regulation of bone mineralization (GO:0030502)2.20102262
193regulation of pseudopodium assembly (GO:0031272)2.18602550
194hippo signaling (GO:0035329)2.17979602

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.77988857
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.87713837
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.46592370
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.59117540
5AR_21909140_ChIP-Seq_LNCAP_Human3.50431876
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.45581791
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.08704093
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.98852297
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.96523084
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.94667831
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.88369022
12FOXA2_19822575_ChIP-Seq_HepG2_Human2.86014407
13ESR1_15608294_ChIP-ChIP_MCF-7_Human2.75152073
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.63356188
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.49343435
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.48178238
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.35779197
18PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.35691047
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.34717353
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.29676432
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.20544457
22ZNF217_24962896_ChIP-Seq_MCF-7_Human2.12647568
23HNF4A_19822575_ChIP-Seq_HepG2_Human2.06254659
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.98584229
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.93438112
26ESR1_21235772_ChIP-Seq_MCF-7_Human1.93279044
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.92859824
28SOX2_27498859_Chip-Seq_STOMACH_Mouse1.88663160
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.87907900
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.84608577
31GATA6_25053715_ChIP-Seq_YYC3_Human1.84467057
32CJUN_26792858_Chip-Seq_BT549_Human1.84317309
33CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.82988797
34TP53_18474530_ChIP-ChIP_U2OS_Human1.80044847
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.79411077
36SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.79345482
37SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.79345482
38CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.78899268
39SOX9_24532713_ChIP-Seq_HFSC_Mouse1.76209484
40STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.74990518
41STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.73955741
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.71741301
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.70023015
44ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.69904729
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.67260405
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64223022
47NRF2_20460467_ChIP-Seq_MEFs_Mouse1.64216797
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.64216797
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.64132363
50AR_21572438_ChIP-Seq_LNCaP_Human1.63598132
51ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.61257262
52TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60794445
53SOX2_20726797_ChIP-Seq_SW620_Human1.60238841
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59971863
55TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59068404
56AHR_22903824_ChIP-Seq_MCF-7_Human1.57072893
57WT1_19549856_ChIP-ChIP_CCG9911_Human1.53991011
58E2F7_22180533_ChIP-Seq_HELA_Human1.52277087
59SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.45456586
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.44475529
61FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44198601
62ATF3_27146783_Chip-Seq_COLON_Human1.43025243
63TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.40914107
64EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.40785867
65TCF4_18268006_ChIP-ChIP_LS174T_Human1.39926274
66GATA2_21666600_ChIP-Seq_HMVEC_Human1.39750516
67TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.38283039
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36837539
69IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.36768849
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36230305
71IRF8_27001747_Chip-Seq_BMDM_Mouse1.35830303
72FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.34189777
73ESR1_20079471_ChIP-ChIP_T-47D_Human1.32275356
74RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31570536
75VDR_24787735_ChIP-Seq_THP-1_Human1.29511117
76CTNNB1_20460455_ChIP-Seq_HCT116_Human1.29060836
77SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28129648
78KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.26884956
79SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.24731474
80ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23675819
81SOX17_20123909_ChIP-Seq_XEN_Mouse1.23628450
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22689512
83TP53_16413492_ChIP-PET_HCT116_Human1.22568839
84STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20947599
85TP63_23658742_ChIP-Seq_EP156T_Human1.20819157
86BRD4_25478319_ChIP-Seq_HGPS_Human1.20611176
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19564146
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.19021699
89NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18205895
90CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17892048
91SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17082651
92FOXM1_23109430_ChIP-Seq_U2OS_Human1.16642436
93SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15420004
94MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12776499
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12756845
96EP300_21415370_ChIP-Seq_HL-1_Mouse1.11481073
97BP1_19119308_ChIP-ChIP_Hs578T_Human1.11199162
98CDX2_20551321_ChIP-Seq_CACO-2_Human1.10917011
99ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10574224
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10376937
101MYC_18555785_ChIP-Seq_MESCs_Mouse1.10176587
102GATA4_25053715_ChIP-Seq_YYC3_Human1.10176315
103CLOCK_20551151_ChIP-Seq_293T_Human1.10086652
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09509489
105FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09109910
106UBF1/2_26484160_Chip-Seq_HMECs_Human1.09050026
107RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08580115
108KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08055625
109CHD1_26751641_Chip-Seq_LNCaP_Human1.07232755
110CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06250976
111POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05784721
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05498399
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04709089
114EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04423575
115JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02840399
116ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02363870
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01799257
118P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01689217
119TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00553035
120SMAD3_21741376_ChIP-Seq_HESCs_Human0.98317259
121PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96816716
122KLF5_25053715_ChIP-Seq_YYC3_Human0.96284291
123RXR_22108803_ChIP-Seq_LS180_Human0.96237728
124NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95963921
125GATA3_24758297_ChIP-Seq_MCF-7_Human0.94034944
126STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93960691
127JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92712242
128TP53_22127205_ChIP-Seq_IMR90_Human0.92174388
129PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91175945
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90942104
131PIAS1_25552417_ChIP-Seq_VCAP_Human0.89599790
132RUNX1_27514584_Chip-Seq_MCF-7_Human0.89217059
133GATA1_22025678_ChIP-Seq_K562_Human0.89147128
134TP53_20018659_ChIP-ChIP_R1E_Mouse0.89066556
135NELFA_20434984_ChIP-Seq_ESCs_Mouse0.88104662
136FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.88051686
137SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.87827874
138TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87715171
139TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87322472
140RUNX_20019798_ChIP-Seq_JUKART_Human0.87054365
141WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87035786
142AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86188432
143PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85510431
144ZNF263_19887448_ChIP-Seq_K562_Human0.85348213
145FOXA1_25552417_ChIP-Seq_VCAP_Human0.85164495
146PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.85043719
147NANOG_21062744_ChIP-ChIP_HESCs_Human0.84582268
148BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.81220972
149ELK3_25401928_ChIP-Seq_HUVEC_Human0.79787972
150SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.78957542
151FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78554241
152RACK7_27058665_Chip-Seq_MCF-7_Human0.78481502
153NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.78048855
154TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.76779300
155THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.75324983

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.36251814
2MP0002148_abnormal_hypersensitivity_rea3.69901691
3MP0005360_urolithiasis3.66198684
4MP0001986_abnormal_taste_sensitivity3.35978590
5MP0002254_reproductive_system_inflammat3.10470809
6MP0010234_abnormal_vibrissa_follicle3.07255989
7MP0001346_abnormal_lacrimal_gland3.05377718
8MP0005365_abnormal_bile_salt2.95995953
9MP0005085_abnormal_gallbladder_physiolo2.85381571
10MP0001348_abnormal_lacrimal_gland2.77577062
11MP0001666_abnormal_nutrient_absorption2.75479767
12MP0003566_abnormal_cell_adhesion2.68099225
13MP0008438_abnormal_cutaneous_collagen2.60083782
14MP0008875_abnormal_xenobiotic_pharmacok2.55232877
15MP0004272_abnormal_basement_membrane2.52425179
16MP0003941_abnormal_skin_development2.51962971
17MP0005409_darkened_coat_color2.51943126
18MP0008004_abnormal_stomach_pH2.43183221
19MP0009697_abnormal_copulation2.41134152
20MP0010352_gastrointestinal_tract_polyps2.28635965
21MP0005275_abnormal_skin_tensile2.26911214
22MP0003705_abnormal_hypodermis_morpholog2.24978903
23MP0002138_abnormal_hepatobiliary_system2.20765522
24MP0003252_abnormal_bile_duct2.19834456
25MP0003122_maternal_imprinting2.19490000
26MP0003950_abnormal_plasma_membrane2.17915804
27MP0003868_abnormal_feces_composition2.17143403
28MP0003436_decreased_susceptibility_to2.13417402
29MP0005408_hypopigmentation2.11607847
30MP0005623_abnormal_meninges_morphology2.02460616
31MP0003191_abnormal_cellular_cholesterol2.00524793
32MP0003091_abnormal_cell_migration1.98148241
33MP0005076_abnormal_cell_differentiation1.95376250
34MP0002009_preneoplasia1.93729313
35MP0010329_abnormal_lipoprotein_level1.93091538
36MP0001835_abnormal_antigen_presentation1.89197119
37MP0002166_altered_tumor_susceptibility1.85178348
38MP0002163_abnormal_gland_morphology1.84566914
39MP0003123_paternal_imprinting1.82068397
40MP0009780_abnormal_chondrocyte_physiolo1.81940252
41MP0005451_abnormal_body_composition1.80601963
42MP0002006_tumorigenesis1.79057659
43MP0000685_abnormal_immune_system1.73489451
44MP0003300_gastrointestinal_ulcer1.71895274
45MP0003195_calcinosis1.71083895
46MP0005023_abnormal_wound_healing1.60496675
47MP0003453_abnormal_keratinocyte_physiol1.59819417
48MP0003045_fibrosis1.56393286
49MP0005000_abnormal_immune_tolerance1.55514244
50MP0004185_abnormal_adipocyte_glucose1.52990269
51MP0005058_abnormal_lysosome_morphology1.52338729
52MP0006054_spinal_hemorrhage1.52323479
53MP0000767_abnormal_smooth_muscle1.51276233
54MP0002295_abnormal_pulmonary_circulatio1.46897752
55MP0002089_abnormal_postnatal_growth/wei1.45828173
56MP0002168_other_aberrant_phenotype1.45427559
57MP0002060_abnormal_skin_morphology1.45394572
58MP0001661_extended_life_span1.45215703
59MP0010678_abnormal_skin_adnexa1.43751433
60MP0004782_abnormal_surfactant_physiolog1.41564609
61MP0010155_abnormal_intestine_physiology1.35707122
62MP0003315_abnormal_perineum_morphology1.35639060
63MP0000383_abnormal_hair_follicle1.34585896
64MP0004510_myositis1.34183939
65MP0005387_immune_system_phenotype1.34117006
66MP0001790_abnormal_immune_system1.34117006
67MP0004858_abnormal_nervous_system1.32694718
68MP0001216_abnormal_epidermal_layer1.32577533
69MP0000490_abnormal_crypts_of1.31611796
70MP0010368_abnormal_lymphatic_system1.30796210
71MP0001533_abnormal_skeleton_physiology1.30547875
72MP0004233_abnormal_muscle_weight1.29847038
73MP0002796_impaired_skin_barrier1.27771521
74MP0004947_skin_inflammation1.21592242
75MP0009785_altered_susceptibility_to1.21083648
76MP0000609_abnormal_liver_physiology1.20704219
77MP0000534_abnormal_ureter_morphology1.20316252
78MP0009053_abnormal_anal_canal1.19982259
79MP0003878_abnormal_ear_physiology1.17881023
80MP0005377_hearing/vestibular/ear_phenot1.17881023
81MP0004264_abnormal_extraembryonic_tissu1.17599782
82MP0002086_abnormal_extraembryonic_tissu1.12620845
83MP0005501_abnormal_skin_physiology1.11784469
84MP0000003_abnormal_adipose_tissue1.09713088
85MP0009384_cardiac_valve_regurgitation1.05855636
86MP0005390_skeleton_phenotype1.05113974
87MP0002098_abnormal_vibrissa_morphology1.04892667
88MP0005367_renal/urinary_system_phenotyp1.04579959
89MP0000516_abnormal_urinary_system1.04579959
90MP0003943_abnormal_hepatobiliary_system1.04494747
91MP0001879_abnormal_lymphatic_vessel1.04247615
92MP0001958_emphysema1.04023610
93MP0009840_abnormal_foam_cell1.03514301
94MP0003303_peritoneal_inflammation1.03314408
95MP0000762_abnormal_tongue_morphology1.02960556
96MP0000013_abnormal_adipose_tissue1.02881984
97MP0005395_other_phenotype1.02567074
98MP0006138_congestive_heart_failure1.01901686
99MP0003183_abnormal_peptide_metabolism1.01717841
100MP0003448_altered_tumor_morphology1.00335609
101MP0002877_abnormal_melanocyte_morpholog1.00269265
102MP0002282_abnormal_trachea_morphology0.98970485
103MP0001730_embryonic_growth_arrest0.97773016
104MP0000377_abnormal_hair_follicle0.97427260
105MP0005508_abnormal_skeleton_morphology0.97068693
106MP0001849_ear_inflammation0.96373831
107MP0002405_respiratory_system_inflammati0.95650775
108MP0002277_abnormal_respiratory_mucosa0.93927339
109MP0001915_intracranial_hemorrhage0.92922490
110MP0002697_abnormal_eye_size0.92766833
111MP0005332_abnormal_amino_acid0.92052242
112MP0003984_embryonic_growth_retardation0.91498394
113MP0000598_abnormal_liver_morphology0.90975036
114MP0002249_abnormal_larynx_morphology0.90840820
115MP0005310_abnormal_salivary_gland0.90149483
116MP0003115_abnormal_respiratory_system0.90092653
117MP0005025_abnormal_response_to0.89494301
118MP0000538_abnormal_urinary_bladder0.87562935
119MP0002092_abnormal_eye_morphology0.87321453
120MP0002118_abnormal_lipid_homeostasis0.87254316
121MP0005257_abnormal_intraocular_pressure0.87233184
122MP0002088_abnormal_embryonic_growth/wei0.86950881
123MP0002419_abnormal_innate_immunity0.86238787
124MP0000566_synostosis0.85988524
125MP0002452_abnormal_antigen_presenting0.85634510
126MP0000467_abnormal_esophagus_morphology0.85300223
127MP0003828_pulmonary_edema0.84598654
128MP0009250_abnormal_appendicular_skeleto0.83967958
129MP0002896_abnormal_bone_mineralization0.83893351
130MP0001672_abnormal_embryogenesis/_devel0.82844092
131MP0005380_embryogenesis_phenotype0.82844092
132MP0005503_abnormal_tendon_morphology0.82170177
133MP0000537_abnormal_urethra_morphology0.82103921
134MP0002998_abnormal_bone_remodeling0.82046220
135MP0005164_abnormal_response_to0.81746840
136MP0009278_abnormal_bone_marrow0.81357821
137MP0000627_abnormal_mammary_gland0.80713515
138MP0003806_abnormal_nucleotide_metabolis0.80704725
139MP0000613_abnormal_salivary_gland0.80125218
140MP0000428_abnormal_craniofacial_morphol0.79411685
141MP0002233_abnormal_nose_morphology0.79152507
142MP0003755_abnormal_palate_morphology0.76593399
143MP0005666_abnormal_adipose_tissue0.75918806
144MP0002928_abnormal_bile_duct0.75320503
145MP0000733_abnormal_muscle_development0.75220715
146MP0003724_increased_susceptibility_to0.74481410
147MP0001800_abnormal_humoral_immune0.74441777
148MP0000569_abnormal_digit_pigmentation0.73640228
149MP0001697_abnormal_embryo_size0.73582464
150MP0003942_abnormal_urinary_system0.73443724
151MP0005464_abnormal_platelet_physiology0.72234967
152MP0010630_abnormal_cardiac_muscle0.72095195
153MP0005248_abnormal_Harderian_gland0.71643066
154MP0003385_abnormal_body_wall0.70008877
155MP0000858_altered_metastatic_potential0.69204344
156MP0009643_abnormal_urine_homeostasis0.67167281
157MP0002128_abnormal_blood_circulation0.67115913
158MP0001614_abnormal_blood_vessel0.66846261
159MP0000678_abnormal_parathyroid_gland0.66571675
160MP0002925_abnormal_cardiovascular_devel0.65884897
161MP0003718_maternal_effect0.65794494

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)8.64677807
2Prolonged partial thromboplastin time (HP:0003645)5.19811114
3Hypobetalipoproteinemia (HP:0003563)4.92006080
4Abnormality of the common coagulation pathway (HP:0010990)4.42808030
5Complement deficiency (HP:0004431)4.40897868
6Flat acetabular roof (HP:0003180)4.28686612
7Joint hemorrhage (HP:0005261)4.10021726
8Right ventricular cardiomyopathy (HP:0011663)4.09276574
9Neonatal short-limb short stature (HP:0008921)3.97123915
10Conjugated hyperbilirubinemia (HP:0002908)3.77329993
11Atrophic scars (HP:0001075)3.75000585
12Abnormality of aromatic amino acid family metabolism (HP:0004338)3.65013028
13Abnormality of carpal bone ossification (HP:0006257)3.61149851
14Abnormality of complement system (HP:0005339)3.56800103
15Lip pit (HP:0100267)3.53120338
16Abnormality of monocarboxylic acid metabolism (HP:0010996)3.45695994
17Hypercholesterolemia (HP:0003124)3.43502258
18Abnormal tarsal ossification (HP:0008369)3.27030196
19Menorrhagia (HP:0000132)3.13033861
20Spontaneous abortion (HP:0005268)3.11867183
21Small epiphyses (HP:0010585)3.09465334
22Hypolipoproteinemia (HP:0010981)3.09232375
23Premature rupture of membranes (HP:0001788)3.09194648
24Hemorrhage of the eye (HP:0011885)3.00965862
25Glomerulonephritis (HP:0000099)2.96333097
26Abnormal vertebral ossification (HP:0100569)2.95875872
27Abnormal ossification of hand bones (HP:0005921)2.93911679
28Abnormality of the intrinsic pathway (HP:0010989)2.89491199
29Peritonitis (HP:0002586)2.81351164
30Xanthomatosis (HP:0000991)2.79719354
31Esophageal varix (HP:0002040)2.78383675
32Epiphyseal dysplasia (HP:0002656)2.77006061
33Cervical subluxation (HP:0003308)2.76818608
34Abnormal hand bone ossification (HP:0010660)2.75824751
35Shallow orbits (HP:0000586)2.74668086
36Protrusio acetabuli (HP:0003179)2.73034494
37Abnormal foot bone ossification (HP:0010675)2.72949360
38Intrahepatic cholestasis (HP:0001406)2.71892122
39Tibial bowing (HP:0002982)2.70442911
40Vertebral compression fractures (HP:0002953)2.69810104
4111 pairs of ribs (HP:0000878)2.64805921
42Distal lower limb muscle weakness (HP:0009053)2.64392518
43Interstitial pulmonary disease (HP:0006530)2.63243502
44Osteolytic defects of the hand bones (HP:0009699)2.56668868
45Osteolytic defects of the phalanges of the hand (HP:0009771)2.56668868
46Acanthocytosis (HP:0001927)2.55026818
47Bronchomalacia (HP:0002780)2.54603397
48Milia (HP:0001056)2.50588918
49Aortic dissection (HP:0002647)2.50557229
50Cardiovascular calcification (HP:0011915)2.47955730
51Neonatal death (HP:0003811)2.43110992
52Myocardial infarction (HP:0001658)2.41925449
53Gastrointestinal infarctions (HP:0005244)2.41751337
54Hematochezia (HP:0002573)2.39771381
55Sex reversal (HP:0012245)2.38320692
56Abnormal sex determination (HP:0012244)2.38320692
57Abnormality of the acetabulum (HP:0003170)2.37475149
58Eczematoid dermatitis (HP:0000976)2.35012882
59Hypoplasia of the capital femoral epiphysis (HP:0003090)2.33644500
60Orchitis (HP:0100796)2.29818870
61Micronodular cirrhosis (HP:0001413)2.29784663
62Fat malabsorption (HP:0002630)2.28697019
63Vascular calcification (HP:0004934)2.27281574
64Broad palm (HP:0001169)2.25607977
65Hypoplastic scapulae (HP:0000882)2.22736782
66Aplasia/Hypoplasia of the scapulae (HP:0006713)2.22736782
67Broad alveolar ridges (HP:0000187)2.22139085
68Recurrent gram-negative bacterial infections (HP:0005420)2.22053794
69Vertebral hypoplasia (HP:0008417)2.21523203
70Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.21523203
71Aplasia cutis congenita (HP:0001057)2.20761312
72Hepatocellular carcinoma (HP:0001402)2.19174240
73Autoimmune thrombocytopenia (HP:0001973)2.17408388
74Fragile skin (HP:0001030)2.16776321
75Cerebral aneurysm (HP:0004944)2.16758415
76Alopecia of scalp (HP:0002293)2.14686049
77Abnormality of the lumbar spine (HP:0100712)2.14432119
78Cupped ribs (HP:0000887)2.13634247
79Limited elbow extension (HP:0001377)2.12227494
80Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.11604881
81Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.10811039
82Subacute progressive viral hepatitis (HP:0006572)2.10267308
83Epidermoid cyst (HP:0200040)2.10223375
84Asymmetry of the thorax (HP:0001555)2.09938845
85Retrobulbar optic neuritis (HP:0100654)2.08618069
86Optic neuritis (HP:0100653)2.08618069
87Dilatation of the ascending aorta (HP:0005111)2.07391951
88Pulmonary artery stenosis (HP:0004415)2.06999069
89Ulnar claw (HP:0001178)2.05180344
90Increased IgM level (HP:0003496)2.04195975
91Advanced eruption of teeth (HP:0006288)2.01754862
92Aortic aneurysm (HP:0004942)2.00265120
93Pterygium (HP:0001059)1.99120801
94Back pain (HP:0003418)1.98461837
95Abnormality of pain sensation (HP:0010832)1.97544959
96Impaired pain sensation (HP:0007328)1.97544959
97Glomerulosclerosis (HP:0000096)1.96093103
98Vascular tortuosity (HP:0004948)1.95521329
99Wide nose (HP:0000445)1.93573380
100Bifid scrotum (HP:0000048)1.92506071
101Missing ribs (HP:0000921)1.92436834
102Ankle contracture (HP:0006466)1.91950617
103Capillary hemangiomas (HP:0005306)1.91158111
104Skin nodule (HP:0200036)1.90732104
105Stomach cancer (HP:0012126)1.90019648
106Plantar hyperkeratosis (HP:0007556)1.89400638
107Germ cell neoplasia (HP:0100728)1.88740822
108Blue sclerae (HP:0000592)1.88335157
109Hypoalphalipoproteinemia (HP:0003233)1.87100154
110Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.86194093
111Absent epiphyses (HP:0010577)1.86194093
112Nephritis (HP:0000123)1.85787573
113Focal segmental glomerulosclerosis (HP:0000097)1.85785130
114Segmental peripheral demyelination/remyelination (HP:0003481)1.85710637
115Aplasia involving bones of the extremities (HP:0009825)1.85209210
116Aplasia involving bones of the upper limbs (HP:0009823)1.85209210
117Aplasia of the phalanges of the hand (HP:0009802)1.85209210
118Abnormal delivery (HP:0001787)1.84925363
119Gingival bleeding (HP:0000225)1.84638848
120Increased connective tissue (HP:0009025)1.84361178
121Hypoplasia of dental enamel (HP:0006297)1.84320123
122Chronic sinusitis (HP:0011109)1.83931380
123Systemic lupus erythematosus (HP:0002725)1.82279617
124Coxa vara (HP:0002812)1.82082172
125Thick nail (HP:0001805)1.81922228
126Abnormality of the right ventricle (HP:0001707)1.81337538
127Aneurysm (HP:0002617)1.81273975
128Coarse hair (HP:0002208)1.81206186
129Diastasis recti (HP:0001540)1.80828980
130Short nail (HP:0001799)1.80698129
131Natal tooth (HP:0000695)1.79192590
132Arterial tortuosity (HP:0005116)1.78955105
133Hypophosphatemic rickets (HP:0004912)1.74570397
134Broad metatarsal (HP:0001783)1.73988801
135Mixed hearing impairment (HP:0000410)1.72519786
136Arterial thrombosis (HP:0004420)1.71123488
137Mitral valve prolapse (HP:0001634)1.71092429
138Pancreatic islet-cell hyperplasia (HP:0004510)1.70299514
139Glossoptosis (HP:0000162)1.69975578
140Hypoplastic labia majora (HP:0000059)1.69610302
141Abnormality of the gastric mucosa (HP:0004295)1.69452069
142Rickets (HP:0002748)1.68317149
143Abnormality of the nasal septum (HP:0000419)1.68283808
144Abnormality of the distal phalanges of the toes (HP:0010182)1.67764393
145Heterotopia (HP:0002282)1.67649198
146Absent frontal sinuses (HP:0002688)1.67531718
147Abnormality of the Achilles tendon (HP:0005109)1.66766497
148Abnormality of the pericardium (HP:0001697)1.66038577
149Aplasia/Hypoplasia of the sternum (HP:0006714)1.66025215
150Ovoid vertebral bodies (HP:0003300)1.65716762
151Camptodactyly of toe (HP:0001836)1.65621801
152Porencephaly (HP:0002132)1.65259338
153Curly hair (HP:0002212)1.64836220
154Broad face (HP:0000283)1.64764640
155Ankyloglossia (HP:0010296)1.64270856
156Myositis (HP:0100614)1.64175888
157Genu recurvatum (HP:0002816)1.63917714
158Recurrent bacterial skin infections (HP:0005406)1.63680225
159Papillary thyroid carcinoma (HP:0002895)1.63201397
160Wormian bones (HP:0002645)1.62769877
161Hypergammaglobulinemia (HP:0010702)1.61642426
162Abnormality of the wing of the ilium (HP:0011867)1.59320843
163Enlarged kidneys (HP:0000105)1.59157282
164Mitral stenosis (HP:0001718)1.58333545
165Overlapping toe (HP:0001845)1.58036910
166Abnormality of the labia majora (HP:0012881)1.57981368
167Flared iliac wings (HP:0002869)1.57613373
168Sprengel anomaly (HP:0000912)1.57159837
169True hermaphroditism (HP:0010459)1.57050362
170Morphological abnormality of the middle ear (HP:0008609)1.56673452
171Abnormality of glycolysis (HP:0004366)1.56244300
172Periodontitis (HP:0000704)1.55858811
173Termporal pattern (HP:0011008)1.55011105
174Insidious onset (HP:0003587)1.55011105
175Osteomalacia (HP:0002749)1.54554543
176Onycholysis (HP:0001806)1.53025601
177Spinal cord lesions (HP:0100561)1.52826614
178Syringomyelia (HP:0003396)1.52826614

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB34.69108157
2TRPM73.70032488
3TRIB33.34481863
4DDR23.32791270
5MAP3K143.20266996
6ICK2.77598738
7SCYL22.55118013
8MST42.37918928
9DMPK2.35866550
10AKT32.28689937
11BMPR22.27613867
12EEF2K2.19719529
13CHUK2.16979126
14MAPKAPK52.14302266
15IKBKB2.13155797
16FRK2.09885558
17TYK22.04021318
18SMG11.95423636
19PIK3CA1.94848373
20WNK41.94261029
21EIF2AK11.91670836
22EPHB21.79682296
23TBK11.78521480
24KSR21.77738912
25EPHA31.75633591
26BMPR1B1.75161714
27EPHB11.73138385
28PKN21.72369152
29BCR1.69371388
30FLT31.61509751
31LATS21.58892271
32LATS11.58753891
33TTN1.58607535
34IRAK31.55376677
35MKNK11.54271964
36RAF11.54214149
37STK31.51692927
38IKBKE1.51611613
39FER1.45290986
40PIM21.45172535
41FGFR11.41984249
42PAK31.41251339
43STK391.39864830
44ERBB41.37685442
45MST1R1.35560577
46FGFR31.35268687
47PAK41.34341656
48PRKD31.29704404
49BRSK21.28356902
50JAK31.28068576
51IRAK11.27698082
52STK241.26813854
53SIK11.26299036
54PTK61.22132033
55MET1.21769658
56JAK11.20867329
57NTRK11.20390090
58MAP3K21.19733760
59EPHA21.18491813
60IRAK21.14177282
61CDK81.13528452
62RPS6KA51.11267490
63NUAK11.08531463
64MAP3K121.07512663
65BMX1.05769252
66LMTK21.05400957
67KSR11.04698492
68MAP3K130.99779636
69CDK70.99151058
70FGFR40.97980150
71LRRK20.94467589
72CDK90.93127296
73PBK0.93001210
74TGFBR20.90451414
75RPS6KA20.88811984
76MTOR0.88527549
77FGFR20.88040676
78RPS6KB20.87842049
79RET0.86631289
80EIF2AK30.85715367
81RIPK40.85237038
82TIE10.84923087
83NME20.82321662
84WNK10.82298921
85MAP2K10.82016128
86PDGFRA0.81959962
87PRKG20.81952822
88MAPKAPK20.81928945
89PTK20.80210783
90HCK0.79900145
91ARAF0.78464460
92MAP3K30.78140939
93MELK0.77924320
94BRSK10.77746783
95JAK20.70716166
96PDPK10.69910690
97PIK3CG0.69663351
98CSF1R0.67323545
99ROCK10.66136677
100RPS6KA60.65960759
101NEK20.65747055
102RPS6KL10.65402378
103RPS6KC10.65402378
104NEK10.65285280
105PRKAA20.64245009
106PAK20.63306329
107TAF10.62198843
108PRKCQ0.61661393
109RIPK10.61094361
110EGFR0.60793944
111RPS6KB10.60143880
112CDK60.60131654
113ERN10.59298444
114NEK90.57749460
115RPS6KA10.57448780
116MATK0.55803736
117BRD40.55270554
118RPS6KA40.55176553
119PRKCE0.54635008
120MAPK110.54521377
121ABL10.52492722
122TSSK60.51008109
123MAP3K10.50096009
124NEK60.48847430
125CDK120.48805282
126TYRO30.48103458
127BTK0.47262383
128STK38L0.45195098
129ERBB20.44577554
130PTK2B0.43542685
131SIK30.43189929
132STK100.42957178
133CSK0.40519100
134SGK30.39296437
135IRAK40.39283130
136TEC0.39209870
137PDGFRB0.39149451
138GSK3A0.38680431
139KDR0.38419050
140CSNK1E0.38154032
141MAP2K30.37594064
142NME10.37347332
143PIM10.36820029
144IGF1R0.36150206
145PRKCD0.35340028
146MAPKAPK30.35287218
147CAMK1D0.35160223
148EIF2AK20.34885916
149STK380.34821250
150SRC0.34529332
151WEE10.33894923
152AKT20.33461442
153ILK0.30235129
154TTK0.25580064
155YES10.23254319
156PDK10.22761070
157CAMK1G0.22716584
158AURKB0.21162671
159DAPK10.18930080

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046104.34616739
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.43927479
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.60341108
4Graft-versus-host disease_Homo sapiens_hsa053322.26336545
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.26258134
6Leishmaniasis_Homo sapiens_hsa051402.21521857
7Arginine biosynthesis_Homo sapiens_hsa002202.20625189
8Allograft rejection_Homo sapiens_hsa053302.15365120
9ECM-receptor interaction_Homo sapiens_hsa045122.08779314
10Toxoplasmosis_Homo sapiens_hsa051452.07235447
11Phenylalanine metabolism_Homo sapiens_hsa003601.99401437
12Fatty acid degradation_Homo sapiens_hsa000711.95773251
13Fatty acid biosynthesis_Homo sapiens_hsa000611.93192773
14TNF signaling pathway_Homo sapiens_hsa046681.85245435
15Vitamin digestion and absorption_Homo sapiens_hsa049771.84939368
16Adherens junction_Homo sapiens_hsa045201.81025871
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.72105392
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.70896375
19Fat digestion and absorption_Homo sapiens_hsa049751.68970675
20Amoebiasis_Homo sapiens_hsa051461.65497990
21Malaria_Homo sapiens_hsa051441.65043304
22Histidine metabolism_Homo sapiens_hsa003401.64401783
23Viral myocarditis_Homo sapiens_hsa054161.64216688
24Steroid biosynthesis_Homo sapiens_hsa001001.63019846
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.61988884
26Starch and sucrose metabolism_Homo sapiens_hsa005001.61750508
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.61750261
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.60955119
29Tyrosine metabolism_Homo sapiens_hsa003501.58570584
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58033928
31Other glycan degradation_Homo sapiens_hsa005111.57664444
32Fatty acid metabolism_Homo sapiens_hsa012121.57474070
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.56697937
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.54825690
35Proteoglycans in cancer_Homo sapiens_hsa052051.54738935
36Small cell lung cancer_Homo sapiens_hsa052221.54506475
37Vitamin B6 metabolism_Homo sapiens_hsa007501.48517291
38PPAR signaling pathway_Homo sapiens_hsa033201.48352313
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.48057413
40Retinol metabolism_Homo sapiens_hsa008301.47664168
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.47140777
42Focal adhesion_Homo sapiens_hsa045101.46828702
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.46054693
44Bile secretion_Homo sapiens_hsa049761.44364501
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43748412
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.43340007
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.42897433
48N-Glycan biosynthesis_Homo sapiens_hsa005101.42790255
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.42727490
50Biosynthesis of amino acids_Homo sapiens_hsa012301.42519506
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.41360815
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.39878063
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38390191
54Primary bile acid biosynthesis_Homo sapiens_hsa001201.37065180
55Leukocyte transendothelial migration_Homo sapiens_hsa046701.34742538
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33791627
57Pertussis_Homo sapiens_hsa051331.32574020
58African trypanosomiasis_Homo sapiens_hsa051431.29656327
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.28845712
60Osteoclast differentiation_Homo sapiens_hsa043801.28370596
61Chemical carcinogenesis_Homo sapiens_hsa052041.27842617
62Dorso-ventral axis formation_Homo sapiens_hsa043201.26816432
63Influenza A_Homo sapiens_hsa051641.26129973
64Measles_Homo sapiens_hsa051621.25979415
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.25003071
66Cyanoamino acid metabolism_Homo sapiens_hsa004601.24277992
67Intestinal immune network for IgA production_Homo sapiens_hsa046721.23745772
68Chronic myeloid leukemia_Homo sapiens_hsa052201.23708952
69Hippo signaling pathway_Homo sapiens_hsa043901.22420806
70ABC transporters_Homo sapiens_hsa020101.21382379
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.18310350
72TGF-beta signaling pathway_Homo sapiens_hsa043501.17507225
73Arginine and proline metabolism_Homo sapiens_hsa003301.17144138
74Platelet activation_Homo sapiens_hsa046111.16902992
75Apoptosis_Homo sapiens_hsa042101.16562924
76Shigellosis_Homo sapiens_hsa051311.16084857
77Prion diseases_Homo sapiens_hsa050201.15559101
78Pancreatic cancer_Homo sapiens_hsa052121.13318508
79Choline metabolism in cancer_Homo sapiens_hsa052311.12784790
80Rheumatoid arthritis_Homo sapiens_hsa053231.12252935
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11613187
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11032597
83Type I diabetes mellitus_Homo sapiens_hsa049401.10294040
84Jak-STAT signaling pathway_Homo sapiens_hsa046301.10012672
85Regulation of actin cytoskeleton_Homo sapiens_hsa048101.07023511
86Carbon metabolism_Homo sapiens_hsa012001.04797935
87MicroRNAs in cancer_Homo sapiens_hsa052061.04602527
88Caffeine metabolism_Homo sapiens_hsa002321.04343332
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04240858
90Prolactin signaling pathway_Homo sapiens_hsa049171.03818277
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03281037
92Lysine degradation_Homo sapiens_hsa003101.01914648
93Fructose and mannose metabolism_Homo sapiens_hsa000511.01636473
94Hepatitis B_Homo sapiens_hsa051611.01533711
95Salmonella infection_Homo sapiens_hsa051321.01435390
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01042227
97Legionellosis_Homo sapiens_hsa051341.00338353
98Chemokine signaling pathway_Homo sapiens_hsa040621.00164525
99Bladder cancer_Homo sapiens_hsa052190.99191573
100Tuberculosis_Homo sapiens_hsa051520.99113968
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98843551
102Hepatitis C_Homo sapiens_hsa051600.97320147
103Endometrial cancer_Homo sapiens_hsa052130.97246292
104Arachidonic acid metabolism_Homo sapiens_hsa005900.97178218
105Dilated cardiomyopathy_Homo sapiens_hsa054140.96267594
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95384416
107Pyruvate metabolism_Homo sapiens_hsa006200.93445824
108Autoimmune thyroid disease_Homo sapiens_hsa053200.92992412
109Prostate cancer_Homo sapiens_hsa052150.92960691
110Acute myeloid leukemia_Homo sapiens_hsa052210.92595949
111Notch signaling pathway_Homo sapiens_hsa043300.91736372
112Pentose phosphate pathway_Homo sapiens_hsa000300.90278527
113Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89885389
114Herpes simplex infection_Homo sapiens_hsa051680.89730105
115Ovarian steroidogenesis_Homo sapiens_hsa049130.87378989
116Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87228205
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.86747821
118VEGF signaling pathway_Homo sapiens_hsa043700.85667585
119Melanoma_Homo sapiens_hsa052180.84007559
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83370323
121Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83330431
122Renin-angiotensin system_Homo sapiens_hsa046140.82795800
123B cell receptor signaling pathway_Homo sapiens_hsa046620.81931556
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81851866
125Pathways in cancer_Homo sapiens_hsa052000.81800382
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.80728392
127Galactose metabolism_Homo sapiens_hsa000520.80003788
128Basal cell carcinoma_Homo sapiens_hsa052170.79119174
129Thyroid cancer_Homo sapiens_hsa052160.79109005
130Propanoate metabolism_Homo sapiens_hsa006400.78563832
131Tight junction_Homo sapiens_hsa045300.78297443
132Tryptophan metabolism_Homo sapiens_hsa003800.78001543
133Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73429018
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.72928874
135ErbB signaling pathway_Homo sapiens_hsa040120.72720135
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72303937
137Cysteine and methionine metabolism_Homo sapiens_hsa002700.70772702
138p53 signaling pathway_Homo sapiens_hsa041150.70648790
139Peroxisome_Homo sapiens_hsa041460.70451147
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70205571
141Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69080494
142Sphingolipid metabolism_Homo sapiens_hsa006000.68233400
143One carbon pool by folate_Homo sapiens_hsa006700.67792228
144Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67567532
145HTLV-I infection_Homo sapiens_hsa051660.67424440
146Thyroid hormone synthesis_Homo sapiens_hsa049180.67312612
147Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66641599
148Insulin resistance_Homo sapiens_hsa049310.65949245
149Axon guidance_Homo sapiens_hsa043600.65326843
150Phagosome_Homo sapiens_hsa041450.65258090
151PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64108142
152Selenocompound metabolism_Homo sapiens_hsa004500.62733387
153Glucagon signaling pathway_Homo sapiens_hsa049220.62384161
154Colorectal cancer_Homo sapiens_hsa052100.61824186
155Rap1 signaling pathway_Homo sapiens_hsa040150.61546311
156alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61084604
157Protein digestion and absorption_Homo sapiens_hsa049740.60918675
158Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60582972
159MAPK signaling pathway_Homo sapiens_hsa040100.59302506
160Non-small cell lung cancer_Homo sapiens_hsa052230.59016982
161Maturity onset diabetes of the young_Homo sapiens_hsa049500.58985890
162Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58478434
163FoxO signaling pathway_Homo sapiens_hsa040680.58459341
164Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57786278
165Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57270317
166Taste transduction_Homo sapiens_hsa047420.56795015
167Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56399399
168Ras signaling pathway_Homo sapiens_hsa040140.55474262
169Neurotrophin signaling pathway_Homo sapiens_hsa047220.54913296
170Sulfur metabolism_Homo sapiens_hsa009200.49713627
171Insulin signaling pathway_Homo sapiens_hsa049100.49366076
172Butanoate metabolism_Homo sapiens_hsa006500.48287816
173AMPK signaling pathway_Homo sapiens_hsa041520.46581519
174beta-Alanine metabolism_Homo sapiens_hsa004100.44113730
175Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42950103
176Glutathione metabolism_Homo sapiens_hsa004800.41702994
177Fatty acid elongation_Homo sapiens_hsa000620.38249205
178mTOR signaling pathway_Homo sapiens_hsa041500.37876155
179Staphylococcus aureus infection_Homo sapiens_hsa051500.32765390
180Mineral absorption_Homo sapiens_hsa049780.27273126

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