ADGRL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cytosolic calcium ion concentration (GO:0051481)4.26858688
2positive regulation of synapse maturation (GO:0090129)4.17280890
3protein localization to synapse (GO:0035418)4.08839780
4layer formation in cerebral cortex (GO:0021819)3.93694850
5axon extension involved in axon guidance (GO:0048846)3.85308016
6neuron projection extension involved in neuron projection guidance (GO:1902284)3.85308016
7notochord development (GO:0030903)3.83063327
8pre-miRNA processing (GO:0031054)3.74064319
9convergent extension (GO:0060026)3.58819014
10axonal fasciculation (GO:0007413)3.52922074
11presynaptic membrane assembly (GO:0097105)3.52634162
12hippo signaling (GO:0035329)3.47110524
13G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.33988973
14synaptic vesicle exocytosis (GO:0016079)3.30900578
15lung-associated mesenchyme development (GO:0060484)3.29733844
16regulation of posttranscriptional gene silencing (GO:0060147)3.26721829
17regulation of gene silencing by miRNA (GO:0060964)3.26721829
18regulation of gene silencing by RNA (GO:0060966)3.26721829
19mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.26238652
20negative regulation of axon extension involved in axon guidance (GO:0048843)3.24249267
21cellular potassium ion homeostasis (GO:0030007)3.22614246
22positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.21742222
23neuron recognition (GO:0008038)3.21500862
24presynaptic membrane organization (GO:0097090)3.19984856
25regulation of synapse maturation (GO:0090128)3.19873832
26cell communication by electrical coupling (GO:0010644)3.18459432
27dorsal/ventral axis specification (GO:0009950)3.16906462
28cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.16524491
29planar cell polarity pathway involved in neural tube closure (GO:0090179)3.16424151
30heterochromatin organization (GO:0070828)3.14952299
31response to pheromone (GO:0019236)3.14924815
32cell migration in hindbrain (GO:0021535)3.13606726
33vocalization behavior (GO:0071625)3.13124642
34exploration behavior (GO:0035640)3.12196141
35cell migration involved in sprouting angiogenesis (GO:0002042)3.11289424
36positive regulation of gastrulation (GO:2000543)3.09607110
37innervation (GO:0060384)3.08858307
38regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.07190777
39negative regulation of catenin import into nucleus (GO:0035414)3.05831494
40cell surface receptor signaling pathway involved in heart development (GO:0061311)3.03142765
41regulation of axon extension involved in axon guidance (GO:0048841)3.01420391
42dendritic spine morphogenesis (GO:0060997)3.00137284
43negative regulation of axon guidance (GO:1902668)2.99616041
44detection of light stimulus involved in visual perception (GO:0050908)2.98313258
45detection of light stimulus involved in sensory perception (GO:0050962)2.98313258
46dendrite morphogenesis (GO:0048813)2.96764830
47positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.96101439
48retinal rod cell development (GO:0046548)2.95867904
49outer ear morphogenesis (GO:0042473)2.94536635
50regulation of cell fate specification (GO:0042659)2.94430974
51sodium ion export (GO:0071436)2.93108252
52Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.90241970
53regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.88299155
54regulation of axon guidance (GO:1902667)2.88166995
55gamma-aminobutyric acid signaling pathway (GO:0007214)2.87292833
56positive regulation of dendritic spine morphogenesis (GO:0061003)2.85964911
57negative regulation of chondrocyte differentiation (GO:0032331)2.85839676
58potassium ion homeostasis (GO:0055075)2.85781654
59positive regulation of SMAD protein import into nucleus (GO:0060391)2.85444769
60neurotransmitter-gated ion channel clustering (GO:0072578)2.84479689
61embryonic foregut morphogenesis (GO:0048617)2.84045451
62regulation of establishment of planar polarity (GO:0090175)2.81041812
63artery development (GO:0060840)2.78075524
64central nervous system projection neuron axonogenesis (GO:0021952)2.77055916
65synaptic vesicle endocytosis (GO:0048488)2.76541650
66limb bud formation (GO:0060174)2.76197750
67chondrocyte proliferation (GO:0035988)2.76174284
68regulation of synapse structural plasticity (GO:0051823)2.75277254
69ephrin receptor signaling pathway (GO:0048013)2.75209857
70non-canonical Wnt signaling pathway (GO:0035567)2.74826526
71lymphangiogenesis (GO:0001946)2.74625427
72nuclear pore complex assembly (GO:0051292)2.74180221
73regulation of non-canonical Wnt signaling pathway (GO:2000050)2.73277152
74midgut development (GO:0007494)2.73035461
75regulation of short-term neuronal synaptic plasticity (GO:0048172)2.72252300
76head development (GO:0060322)2.71911566
77regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.69881493
78paraxial mesoderm development (GO:0048339)2.68146112
79pyrimidine nucleobase catabolic process (GO:0006208)2.67592049
80establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.66440113
81urinary tract smooth muscle contraction (GO:0014848)2.62663317
82homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.62014751
83axon extension (GO:0048675)2.61791919
84establishment of tissue polarity (GO:0007164)2.59984170
85establishment of planar polarity (GO:0001736)2.59984170
86negative chemotaxis (GO:0050919)2.57292705
87regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.54385704
88prepulse inhibition (GO:0060134)2.54094713
89cardiac myofibril assembly (GO:0055003)2.53961518
90synaptic vesicle docking involved in exocytosis (GO:0016081)2.53729640
91gap junction assembly (GO:0016264)2.53407906
92cell communication involved in cardiac conduction (GO:0086065)2.53015841
93negative regulation of keratinocyte proliferation (GO:0010839)2.52115116
94nuclear pore organization (GO:0006999)2.52067915
95metanephric mesenchyme development (GO:0072075)2.51717578
96synaptic vesicle maturation (GO:0016188)2.51283184
97gastrulation with mouth forming second (GO:0001702)2.51001613
98regulation of dendritic spine morphogenesis (GO:0061001)2.50717558
99regulation of glutamate receptor signaling pathway (GO:1900449)2.50193137
100apical protein localization (GO:0045176)2.49770110
101morphogenesis of an epithelial sheet (GO:0002011)2.49581582
102sequestering of extracellular ligand from receptor (GO:0035581)2.49525462
103glomerular filtration (GO:0003094)2.49236180
104neuron cell-cell adhesion (GO:0007158)2.48511710
105renal filtration (GO:0097205)2.48430150
106negative regulation of DNA repair (GO:0045738)2.48049414
107mesenchymal to epithelial transition (GO:0060231)2.47851955
108establishment of nucleus localization (GO:0040023)2.46369883
109retina vasculature morphogenesis in camera-type eye (GO:0061299)2.44891401
110atrial cardiac muscle cell action potential (GO:0086014)2.44869903
111mesenchymal cell differentiation (GO:0048762)2.44436866
112positive regulation of catenin import into nucleus (GO:0035413)2.43942252
113post-anal tail morphogenesis (GO:0036342)2.43344392
114glutamate receptor signaling pathway (GO:0007215)2.42686675
115regulation of cardioblast differentiation (GO:0051890)2.42405125
116positive regulation of dendrite morphogenesis (GO:0050775)2.41189504
117embryonic retina morphogenesis in camera-type eye (GO:0060059)2.41170339
118neuronal stem cell maintenance (GO:0097150)2.41147606
119ganglion development (GO:0061548)2.40979296
120calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.40461234
121locomotory exploration behavior (GO:0035641)2.40443486
122cochlea development (GO:0090102)2.40049872
123plasma membrane repair (GO:0001778)2.39976629
124heart morphogenesis (GO:0003007)2.39335703
125DNA unwinding involved in DNA replication (GO:0006268)2.37766394
126camera-type eye morphogenesis (GO:0048593)2.37689019
127body morphogenesis (GO:0010171)2.37648912
128branching involved in salivary gland morphogenesis (GO:0060445)2.37449590
129bone trabecula formation (GO:0060346)2.36785276
130glial cell proliferation (GO:0014009)2.36238549
131negative regulation of cell fate specification (GO:0009996)2.35980336
132insulin-like growth factor receptor signaling pathway (GO:0048009)2.35938010
133regulation of synaptic vesicle exocytosis (GO:2000300)2.35813766
134ectodermal placode formation (GO:0060788)2.35216995
135negative regulation of vascular permeability (GO:0043116)2.35138824
136regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.34339694
137cerebellar Purkinje cell differentiation (GO:0021702)2.33614617
138regulation of growth hormone secretion (GO:0060123)2.33599176
139mating behavior (GO:0007617)2.33468137
140heparan sulfate proteoglycan metabolic process (GO:0030201)2.33221167
141lymph vessel development (GO:0001945)2.33197135
142asymmetric protein localization (GO:0008105)2.32916171
143lateral sprouting from an epithelium (GO:0060601)2.31560171
144regulation of catenin import into nucleus (GO:0035412)2.30649017
145relaxation of smooth muscle (GO:0044557)2.30170406
146glomerulus development (GO:0032835)2.30136891
147motor neuron axon guidance (GO:0008045)2.29238693
148establishment or maintenance of monopolar cell polarity (GO:0061339)2.29235122
149establishment of monopolar cell polarity (GO:0061162)2.29235122
150kidney mesenchyme development (GO:0072074)2.28901368
151neural tube closure (GO:0001843)2.28756353
152tube closure (GO:0060606)2.28694735
153regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.28106553
154G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.28013475
155anterior/posterior axis specification, embryo (GO:0008595)2.27211457
156olfactory bulb development (GO:0021772)2.26900980
157protein localization to kinetochore (GO:0034501)2.26322306
158regulation of stem cell maintenance (GO:2000036)2.26136152
159myelination in peripheral nervous system (GO:0022011)2.25409239
160peripheral nervous system axon ensheathment (GO:0032292)2.25409239
161establishment or maintenance of apical/basal cell polarity (GO:0035088)2.25321575
162establishment or maintenance of bipolar cell polarity (GO:0061245)2.25321575
163genitalia morphogenesis (GO:0035112)2.25146093
164dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.24924936
165craniofacial suture morphogenesis (GO:0097094)2.22371326
166Notch signaling involved in heart development (GO:0061314)2.21263240
167establishment of apical/basal cell polarity (GO:0035089)2.20839634
168establishment of integrated proviral latency (GO:0075713)2.20288009
169regulation of SMAD protein import into nucleus (GO:0060390)2.19782902
170nucleobase catabolic process (GO:0046113)2.19433725
171mitotic sister chromatid cohesion (GO:0007064)2.18832964
172prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.18716385
173inner ear receptor cell development (GO:0060119)2.16141828

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.42448172
2EZH2_22144423_ChIP-Seq_EOC_Human3.18667369
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.70236324
4GBX2_23144817_ChIP-Seq_PC3_Human2.69060328
5E2F7_22180533_ChIP-Seq_HELA_Human2.64338128
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64138772
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61972864
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61972864
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.61438053
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.60055939
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.58408978
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.55431123
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49428166
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.49264009
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.49255040
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49136306
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.22449082
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.17452802
19POU5F1_16153702_ChIP-ChIP_HESCs_Human2.17449986
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11810600
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.06368836
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.04244665
23MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02468076
24DROSHA_22980978_ChIP-Seq_HELA_Human1.94144645
25PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.94048232
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92540201
27AR_21572438_ChIP-Seq_LNCaP_Human1.88920770
28RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.88734702
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87926816
30SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.87190786
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77990640
32AR_21909140_ChIP-Seq_LNCAP_Human1.77912809
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.75635070
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72409415
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.71909903
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71669556
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70317893
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64150227
39SOX2_16153702_ChIP-ChIP_HESCs_Human1.62105012
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.61655623
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.58921268
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58670376
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57746088
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.56860804
45EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.55054509
46RING1B_27294783_Chip-Seq_NPCs_Mouse1.53304020
47ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52199714
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.52111613
49EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51326298
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50494099
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46790478
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.46704896
53STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.46162262
54TBX3_20139965_ChIP-Seq_MESCs_Mouse1.46060129
55TBX3_20139965_ChIP-Seq_ESCs_Mouse1.45740719
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45420691
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.44504385
58KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44407953
59KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44407953
60KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44407953
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43482286
62ISL1_27105846_Chip-Seq_CPCs_Mouse1.43223089
63TP53_20018659_ChIP-ChIP_R1E_Mouse1.42154367
64REST_21632747_ChIP-Seq_MESCs_Mouse1.40979214
65NANOG_16153702_ChIP-ChIP_HESCs_Human1.39904531
66EWS_26573619_Chip-Seq_HEK293_Human1.39734130
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38797444
68SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.38683294
69SMAD4_21799915_ChIP-Seq_A2780_Human1.38279915
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.36887939
71POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.36435838
72TCF3_18692474_ChIP-Seq_MESCs_Mouse1.36213560
73SOX9_26525672_Chip-Seq_HEART_Mouse1.35907473
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.35614557
75AHR_22903824_ChIP-Seq_MCF-7_Human1.35409223
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31641109
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.31265570
78TAF15_26573619_Chip-Seq_HEK293_Human1.31168670
79WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30317052
80ZNF274_21170338_ChIP-Seq_K562_Hela1.28849122
81TCF3_18692474_ChIP-Seq_MEFs_Mouse1.28429923
82RARB_27405468_Chip-Seq_BRAIN_Mouse1.26914595
83SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.25753627
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25269824
85DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.24912275
86FUS_26573619_Chip-Seq_HEK293_Human1.24376599
87E2F4_17652178_ChIP-ChIP_JURKAT_Human1.24226012
88POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23898891
89AR_19668381_ChIP-Seq_PC3_Human1.23739348
90TP63_19390658_ChIP-ChIP_HaCaT_Human1.23455807
91SMAD_19615063_ChIP-ChIP_OVARY_Human1.23034656
92P300_19829295_ChIP-Seq_ESCs_Human1.22552739
93KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22001653
94SOX2_21211035_ChIP-Seq_LN229_Gbm1.21450342
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21449463
96ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21339644
97CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21151474
98NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.20831535
99TP53_18474530_ChIP-ChIP_U2OS_Human1.20428685
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19885332
101TP53_16413492_ChIP-PET_HCT116_Human1.19269923
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19096508
103YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18610848
104TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18580539
105NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.18246145
106ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17713066
107RNF2_27304074_Chip-Seq_NSC_Mouse1.17192923
108STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17090917
109ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.15232030
110ERG_21242973_ChIP-ChIP_JURKAT_Human1.15165237
111AR_25329375_ChIP-Seq_VCAP_Human1.14355542
112GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13846543
113SMAD4_21741376_ChIP-Seq_HESCs_Human1.13784050
114WT1_19549856_ChIP-ChIP_CCG9911_Human1.13634089
115P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13222398
116TCF4_18268006_ChIP-ChIP_LS174T_Human1.12214357
117SMAD3_21741376_ChIP-Seq_HESCs_Human1.11634779
118TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11265022
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10626830
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10417986
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10417986
122ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09887126
123SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09707748
124TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09251561
125TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.08638703
126NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07036416
127GATA1_26923725_Chip-Seq_HPCs_Mouse1.06214625
128PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06018562
129ESR1_20079471_ChIP-ChIP_T-47D_Human1.05996504
130BCAT_22108803_ChIP-Seq_LS180_Human1.05915358
131IGF1R_20145208_ChIP-Seq_DFB_Human1.04928658
132TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04877792
133ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03049734
134TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02501737
135KDM2B_26808549_Chip-Seq_K562_Human1.02335382
136FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99489567
137OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98463908
138NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97635024

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.10116145
2MP0005248_abnormal_Harderian_gland2.91340268
3MP0010368_abnormal_lymphatic_system2.37506918
4MP0003385_abnormal_body_wall2.33269328
5MP0003705_abnormal_hypodermis_morpholog2.23653047
6MP0003122_maternal_imprinting2.12475025
7MP0004859_abnormal_synaptic_plasticity2.07459947
8MP0004272_abnormal_basement_membrane2.06590558
9MP0004233_abnormal_muscle_weight2.06562429
10MP0003880_abnormal_central_pattern2.02952590
11MP0001984_abnormal_olfaction1.95982158
12MP0000537_abnormal_urethra_morphology1.91324185
13MP0009053_abnormal_anal_canal1.90444108
14MP0005623_abnormal_meninges_morphology1.86517615
15MP0000566_synostosis1.82238736
16MP0005503_abnormal_tendon_morphology1.81682454
17MP0000534_abnormal_ureter_morphology1.81632879
18MP0005551_abnormal_eye_electrophysiolog1.77891419
19MP0002090_abnormal_vision1.75297231
20MP0001346_abnormal_lacrimal_gland1.62124715
21MP0003942_abnormal_urinary_system1.61650173
22MP0008789_abnormal_olfactory_epithelium1.61280778
23MP0000569_abnormal_digit_pigmentation1.61264499
24MP0010234_abnormal_vibrissa_follicle1.59702425
25MP0003941_abnormal_skin_development1.58706805
26MP0003635_abnormal_synaptic_transmissio1.58544570
27MP0000778_abnormal_nervous_system1.55621011
28MP0002234_abnormal_pharynx_morphology1.55168005
29MP0004215_abnormal_myocardial_fiber1.54967541
30MP0000751_myopathy1.52598131
31MP0001286_abnormal_eye_development1.50925108
32MP0003567_abnormal_fetal_cardiomyocyte1.50590530
33MP0005394_taste/olfaction_phenotype1.49226929
34MP0005499_abnormal_olfactory_system1.49226929
35MP0005187_abnormal_penis_morphology1.49191056
36MP0002092_abnormal_eye_morphology1.46193940
37MP0002249_abnormal_larynx_morphology1.44356488
38MP0002184_abnormal_innervation1.44161387
39MP0002084_abnormal_developmental_patter1.42340734
40MP0005275_abnormal_skin_tensile1.41333567
41MP0009250_abnormal_appendicular_skeleto1.40039565
42MP0005257_abnormal_intraocular_pressure1.38705446
43MP0003935_abnormal_craniofacial_develop1.38592314
44MP0000049_abnormal_middle_ear1.36970834
45MP0003890_abnormal_embryonic-extraembry1.36844932
46MP0002063_abnormal_learning/memory/cond1.36782517
47MP0003755_abnormal_palate_morphology1.34648318
48MP0006292_abnormal_olfactory_placode1.33713816
49MP0001486_abnormal_startle_reflex1.33476213
50MP0002233_abnormal_nose_morphology1.33031629
51MP0003937_abnormal_limbs/digits/tail_de1.30046336
52MP0003115_abnormal_respiratory_system1.29693229
53MP0001879_abnormal_lymphatic_vessel1.29611943
54MP0002932_abnormal_joint_morphology1.28505492
55MP0002085_abnormal_embryonic_tissue1.27474996
56MP0009697_abnormal_copulation1.26797535
57MP0000516_abnormal_urinary_system1.25211926
58MP0005367_renal/urinary_system_phenotyp1.25211926
59MP0004084_abnormal_cardiac_muscle1.22961550
60MP0000428_abnormal_craniofacial_morphol1.22328398
61MP0002111_abnormal_tail_morphology1.21560776
62MP0000432_abnormal_head_morphology1.21046964
63MP0008932_abnormal_embryonic_tissue1.19577856
64MP0003121_genomic_imprinting1.18487305
65MP0000631_abnormal_neuroendocrine_gland1.17387328
66MP0010352_gastrointestinal_tract_polyps1.15906178
67MP0003938_abnormal_ear_development1.15772292
68MP0003283_abnormal_digestive_organ1.15558285
69MP0004145_abnormal_muscle_electrophysio1.15476285
70MP0009703_decreased_birth_body1.15392907
71MP0003137_abnormal_impulse_conducting1.14938875
72MP0003119_abnormal_digestive_system1.14071869
73MP0009780_abnormal_chondrocyte_physiolo1.13353331
74MP0008438_abnormal_cutaneous_collagen1.08783806
75MP0006072_abnormal_retinal_apoptosis1.08782631
76MP0002938_white_spotting1.07580483
77MP0001849_ear_inflammation1.07311429
78MP0003315_abnormal_perineum_morphology1.05267764
79MP0002108_abnormal_muscle_morphology1.05236765
80MP0002697_abnormal_eye_size1.04630826
81MP0003878_abnormal_ear_physiology1.04378604
82MP0005377_hearing/vestibular/ear_phenot1.04378604
83MP0004133_heterotaxia1.02267138
84MP0003123_paternal_imprinting1.01963166
85MP0005195_abnormal_posterior_eye1.01680844
86MP0001502_abnormal_circadian_rhythm1.01521742
87MP0003136_yellow_coat_color1.01486106
88MP0005380_embryogenesis_phenotype1.00144922
89MP0001672_abnormal_embryogenesis/_devel1.00144922
90MP0002751_abnormal_autonomic_nervous1.00035729
91MP0003279_aneurysm0.99527993
92MP0008057_abnormal_DNA_replication0.98882482
93MP0000462_abnormal_digestive_system0.98306006
94MP0003861_abnormal_nervous_system0.98063806
95MP0002282_abnormal_trachea_morphology0.97823854
96MP0000762_abnormal_tongue_morphology0.97545241
97MP0003984_embryonic_growth_retardation0.97303301
98MP0005197_abnormal_uvea_morphology0.96546208
99MP0004197_abnormal_fetal_growth/weight/0.96329080
100MP0002088_abnormal_embryonic_growth/wei0.95712570
101MP0004085_abnormal_heartbeat0.94344388
102MP0001340_abnormal_eyelid_morphology0.93960292
103MP0005391_vision/eye_phenotype0.92999799
104MP0004957_abnormal_blastocyst_morpholog0.92963642
105MP0009046_muscle_twitch0.92877372
106MP0009384_cardiac_valve_regurgitation0.92638964
107MP0004858_abnormal_nervous_system0.90876754
108MP0002127_abnormal_cardiovascular_syste0.90483922
109MP0002116_abnormal_craniofacial_bone0.90471707
110MP0001915_intracranial_hemorrhage0.89935033
111MP0009745_abnormal_behavioral_response0.89802250
112MP0002572_abnormal_emotion/affect_behav0.88502564
113MP0002152_abnormal_brain_morphology0.87518368
114MP0002081_perinatal_lethality0.87425958
115MP0000579_abnormal_nail_morphology0.86461163
116MP0001293_anophthalmia0.85532252
117MP0001730_embryonic_growth_arrest0.85165897
118MP0002009_preneoplasia0.84174429
119MP0001299_abnormal_eye_distance/0.83421756
120MP0005595_abnormal_vascular_smooth0.82138959
121MP0002064_seizures0.81952849
122MP0002557_abnormal_social/conspecific_i0.81780676
123MP0002882_abnormal_neuron_morphology0.81734873
124MP0006054_spinal_hemorrhage0.81721084
125MP0006138_congestive_heart_failure0.79961184
126MP0005508_abnormal_skeleton_morphology0.79957256
127MP0002109_abnormal_limb_morphology0.79832564
128MP0001177_atelectasis0.79486493
129MP0002089_abnormal_postnatal_growth/wei0.79350513
130MP0005423_abnormal_somatic_nervous0.79234144
131MP0008775_abnormal_heart_ventricle0.79078452
132MP0002925_abnormal_cardiovascular_devel0.78832800
133MP0003950_abnormal_plasma_membrane0.78471663
134MP0000955_abnormal_spinal_cord0.77656858
135MP0004270_analgesia0.77219802
136MP0003566_abnormal_cell_adhesion0.77074574
137MP0001188_hyperpigmentation0.76667265
138MP0009672_abnormal_birth_weight0.75839863
139MP0004811_abnormal_neuron_physiology0.74501260

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.89167515
2Short 4th metacarpal (HP:0010044)4.89167515
3Congenital stationary night blindness (HP:0007642)4.35137411
4Abnormality of the 4th metacarpal (HP:0010012)3.83393363
5Shallow orbits (HP:0000586)3.77048515
6Vitreoretinal degeneration (HP:0000655)3.21222379
7Hepatoblastoma (HP:0002884)3.07018282
8Central scotoma (HP:0000603)2.74749800
9Protrusio acetabuli (HP:0003179)2.68081639
10Broad metatarsal (HP:0001783)2.60915123
11Lymphangioma (HP:0100764)2.56064292
12Septo-optic dysplasia (HP:0100842)2.50357406
13Cutaneous finger syndactyly (HP:0010554)2.49369687
14Cortical dysplasia (HP:0002539)2.48242347
15High anterior hairline (HP:0009890)2.47681268
16Midline defect of the nose (HP:0004122)2.47233190
17Neonatal short-limb short stature (HP:0008921)2.47062739
18Renal duplication (HP:0000075)2.44976700
19Preaxial foot polydactyly (HP:0001841)2.43191669
20Aplasia involving bones of the upper limbs (HP:0009823)2.35146714
21Aplasia of the phalanges of the hand (HP:0009802)2.35146714
22Aplasia involving bones of the extremities (HP:0009825)2.35146714
23Abnormality of the ischium (HP:0003174)2.35124094
24Epileptic encephalopathy (HP:0200134)2.33925869
25Microglossia (HP:0000171)2.29003788
26Abnormality of the aortic arch (HP:0012303)2.25747321
27Buphthalmos (HP:0000557)2.25656247
28Bifid tongue (HP:0010297)2.22054084
29Myelomeningocele (HP:0002475)2.20087519
30Partial duplication of thumb phalanx (HP:0009944)2.16793829
31Anophthalmia (HP:0000528)2.14605387
32Omphalocele (HP:0001539)2.13118421
33Choanal stenosis (HP:0000452)2.12574424
34Vertebral arch anomaly (HP:0008438)2.12531751
35Partial duplication of the phalanx of hand (HP:0009999)2.11513135
36Broad long bones (HP:0005622)2.10524622
37Flat cornea (HP:0007720)2.09982049
38Premature rupture of membranes (HP:0001788)2.08014012
39Cutaneous syndactyly (HP:0012725)2.07960588
40Morphological abnormality of the middle ear (HP:0008609)2.07498451
41Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.06511352
42Abnormality of abdominal situs (HP:0011620)2.03411793
43Abdominal situs inversus (HP:0003363)2.03411793
44Febrile seizures (HP:0002373)2.03190938
45Absence seizures (HP:0002121)2.01504532
46Broad phalanges of the hand (HP:0009768)1.99889454
47Renovascular hypertension (HP:0100817)1.99696765
48Broad phalanx (HP:0006009)1.99612470
49Colon cancer (HP:0003003)1.99262676
50Progressive cerebellar ataxia (HP:0002073)1.98996411
51Wrist flexion contracture (HP:0001239)1.98635570
52Esophageal atresia (HP:0002032)1.97756415
53Vertebral clefting (HP:0008428)1.97165615
54Skull defect (HP:0001362)1.97096566
55Elfin facies (HP:0004428)1.97037669
56Arnold-Chiari malformation (HP:0002308)1.95809935
57Genetic anticipation (HP:0003743)1.95146224
58Abnormality of macular pigmentation (HP:0008002)1.92807919
59Hydroureter (HP:0000072)1.92004284
60Drooling (HP:0002307)1.91847994
61Excessive salivation (HP:0003781)1.91847994
62Abnormality of the phalanges of the 2nd finger (HP:0009541)1.91810895
63Trigonocephaly (HP:0000243)1.91084627
64Neoplasm of the heart (HP:0100544)1.91063466
65Bicornuate uterus (HP:0000813)1.89399544
66Focal seizures (HP:0007359)1.88147150
67Absent eyebrow (HP:0002223)1.86375708
68Abnormal lung lobation (HP:0002101)1.86250144
69Bilateral microphthalmos (HP:0007633)1.86150394
70Hypoplastic labia majora (HP:0000059)1.84159190
71Abnormality of dentin (HP:0010299)1.81433697
72Duplication of thumb phalanx (HP:0009942)1.79351401
73Scotoma (HP:0000575)1.78885010
74Narrow nasal bridge (HP:0000446)1.78822070
75Abnormality of the parietal bone (HP:0002696)1.78752884
76Obsessive-compulsive behavior (HP:0000722)1.78731004
77Asymmetry of the thorax (HP:0001555)1.78222142
78Increased nuchal translucency (HP:0010880)1.77362878
79Broad toe (HP:0001837)1.77109329
80Absent eyelashes (HP:0000561)1.76547961
81Narrow palate (HP:0000189)1.75922120
82Aortic aneurysm (HP:0004942)1.75561116
83Broad palm (HP:0001169)1.75302338
84Coronal craniosynostosis (HP:0004440)1.74855384
85Hypoplastic ischia (HP:0003175)1.74421808
86Prolonged QT interval (HP:0001657)1.73274650
87Aqueductal stenosis (HP:0002410)1.72659518
88Renal hypoplasia (HP:0000089)1.72527582
89Bladder diverticulum (HP:0000015)1.71470252
90Long toe (HP:0010511)1.71313367
91Turricephaly (HP:0000262)1.71178372
92Mitral valve prolapse (HP:0001634)1.71101869
93Pointed chin (HP:0000307)1.70770859
94Spastic diplegia (HP:0001264)1.70557735
95Thin ribs (HP:0000883)1.70351797
96Chorioretinal atrophy (HP:0000533)1.70010946
97Aplasia/Hypoplasia of the sternum (HP:0006714)1.69737897
98Limited hip movement (HP:0008800)1.69368819
99Abnormality of the antihelix (HP:0009738)1.67513156
100Abnormality of the phalanges of the hallux (HP:0010057)1.67186534
101Abnormality of the diencephalon (HP:0010662)1.66226016
102Labial hypoplasia (HP:0000066)1.66082496
103Intestinal atresia (HP:0011100)1.64963011
104Hypoplasia of the maxilla (HP:0000327)1.64730165
105Abnormality of the nasal septum (HP:0000419)1.63885178
106Bronchomalacia (HP:0002780)1.63678651
107Abnormality of the labia minora (HP:0012880)1.63674328
108Overgrowth (HP:0001548)1.63558700
109Abnormality of the middle phalanges of the toes (HP:0010183)1.62676356
110Soft skin (HP:0000977)1.61979666
111Alacrima (HP:0000522)1.61835246
112Ankyloglossia (HP:0010296)1.61378438
113Hyperacusis (HP:0010780)1.60888087
114Abnormality of the calcaneus (HP:0008364)1.60842221
115Arterial tortuosity (HP:0005116)1.60407270
116Wide cranial sutures (HP:0010537)1.59945161
117Missing ribs (HP:0000921)1.59555159
118Hemivertebrae (HP:0002937)1.59317389
119Papillary thyroid carcinoma (HP:0002895)1.58620508
120Abnormality of the labia majora (HP:0012881)1.58352687
121Facial cleft (HP:0002006)1.58326145
122Wide anterior fontanel (HP:0000260)1.58232129
123Abnormality of the distal phalanx of the thumb (HP:0009617)1.58074565
124Short middle phalanx of finger (HP:0005819)1.58043404
125Mutism (HP:0002300)1.57417782
126Broad thumb (HP:0011304)1.56912853
127Tracheomalacia (HP:0002779)1.56217707
128Hypoventilation (HP:0002791)1.55672635
129Broad finger (HP:0001500)1.54420433
130Cerebral aneurysm (HP:0004944)1.53925240
131Abnormality of the sella turcica (HP:0002679)1.53395092
132EEG with generalized epileptiform discharges (HP:0011198)1.53344408
133Ulnar bowing (HP:0003031)1.53059350
134Decreased lacrimation (HP:0000633)1.52169907
135Vascular tortuosity (HP:0004948)1.51946659
136Severe Myopia (HP:0011003)1.51669431
137Generalized hypotonia (HP:0001290)1.51374470
138Abnormality of the pubic bones (HP:0003172)1.50956844
139Gastrointestinal carcinoma (HP:0002672)1.50933210
140Malignant gastrointestinal tract tumors (HP:0006749)1.50933210
141Broad hallux (HP:0010055)1.50708776
142Atrophic scars (HP:0001075)1.50505014
143Epileptiform EEG discharges (HP:0011182)1.50334145
144Keratoconus (HP:0000563)1.50309894
145Increased corneal curvature (HP:0100692)1.50309894
146Gastrointestinal atresia (HP:0002589)1.50277888
147Oligodontia (HP:0000677)1.50197980
148Abnormality of the lacrimal duct (HP:0011481)1.50126987
149Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.49849266
150Enlarged penis (HP:0000040)1.49840222
151Deviation of the hallux (HP:0010051)1.49682129
152Dysdiadochokinesis (HP:0002075)1.49549543
153Broad ribs (HP:0000885)1.49369725
154Abnormality of the calf musculature (HP:0001430)1.49056336
1552-3 toe syndactyly (HP:0004691)1.48941565
156Partial agenesis of the corpus callosum (HP:0001338)1.48867205
157Tracheal stenosis (HP:0002777)1.48304661
158Facial hemangioma (HP:0000329)1.47905596
159Abnormal number of incisors (HP:0011064)1.47811203
160Ectopic kidney (HP:0000086)1.47504254
161Maternal diabetes (HP:0009800)1.47354342
162Short hallux (HP:0010109)1.47321949
163Aplasia/Hypoplasia of the breasts (HP:0010311)1.46306335
164Short phalanx of the thumb (HP:0009660)1.46245049
165Bowel diverticulosis (HP:0005222)1.45476881
166Myokymia (HP:0002411)1.45088105
167Volvulus (HP:0002580)1.44779025

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.29114926
2LATS13.12721409
3MARK13.11952671
4EPHB22.55101525
5RIPK12.46363501
6MKNK12.45135546
7EPHA32.35974477
8MKNK22.34446896
9TNIK2.23642958
10LATS22.16169292
11MAP3K41.96292140
12BCR1.94198659
13PAK61.90917611
14CAMK1G1.90334992
15CDC71.88071940
16MINK11.85031250
17DAPK21.78654688
18FER1.76514043
19NEK11.64304805
20TTK1.64041237
21SRPK11.63955816
22SIK21.62451345
23NTRK31.59594711
24MAP3K91.58686407
25KSR11.57055616
26TAF11.54759828
27SIK11.53938251
28ERBB31.53741710
29PDGFRA1.48705532
30PKN21.47939620
31FGFR21.47173398
32PHKG21.43197811
33PHKG11.43197811
34DDR21.40066817
35FGFR11.37702732
36CAMK1D1.37026510
37TTN1.34840705
38NTRK21.31671423
39PLK41.30454136
40TAOK21.27526270
41BMX1.25060012
42DMPK1.24287088
43PNCK1.23620265
44PAK31.20135074
45PLK21.18246881
46STK381.17891482
47TIE11.17223429
48PRPF4B1.14070439
49WNK31.12470400
50MAP2K41.11660686
51DYRK1A1.08107982
52PLK31.07918661
53STK38L1.00840010
54CSNK1G10.99264237
55PTK20.98344220
56MET0.98100361
57ERBB20.97577912
58BRD40.96554488
59WEE10.94381269
60TSSK60.93897714
61CAMKK10.93076105
62KDR0.92876947
63CDK120.92765073
64PTK60.92266171
65MAPK130.91787144
66PTK2B0.89327939
67INSRR0.88346732
68TGFBR10.85337783
69YES10.84009175
70ICK0.81585526
71MTOR0.81023535
72DYRK30.80741446
73MAP2K70.80641226
74CSNK1G20.80634898
75PRKD30.79895253
76CASK0.79791204
77TRIB30.79504601
78PDGFRB0.78603943
79MAP3K70.78198375
80ROCK10.75449500
81ERBB40.74814588
82CDK50.73034216
83NLK0.71288101
84AKT30.70641775
85CDK190.69982458
86LMTK20.69603436
87CAMK40.68203231
88PAK20.67497093
89PRKCG0.67362495
90BUB10.67083268
91NEK20.66796197
92BRSK20.66672057
93FLT30.65878802
94PRKCE0.65583447
95PLK10.64763366
96CHEK20.63067766
97EEF2K0.62809388
98KSR20.62457387
99ATM0.62419904
100UHMK10.60759231
101ZAK0.60048752
102TYRO30.59816508
103MAPK100.58535205
104PRKCZ0.57809464
105FGFR40.56177972
106STK240.56100112
107PASK0.55912527
108TRIM280.55881467
109CAMK2A0.55878050
110CDC42BPA0.55419801
111CDK60.54750735
112MARK20.54411689
113NTRK10.54034142
114CDK11A0.53943561
115STK110.53879503
116FRK0.53396380
117CSNK1G30.53094325
118CDK140.53055363
119ATR0.51852630
120MAPK90.51772885
121TGFBR20.51153889
122CSNK1E0.50561178
123TNK20.50471222
124PAK40.50269928
125CAMK10.50238057
126PRKDC0.50057671
127SGK20.49518119
128CSNK1A1L0.48330980
129CHEK10.48099820
130RET0.48093815
131CDK180.47450454
132MAP3K100.47270620
133MAPK80.46953767
134CDK150.46873923
135ROCK20.46248347
136RPS6KA30.45201981
137STK30.43980143
138CDK10.43463896
139MST1R0.43438954
140AKT20.42846905
141SRC0.42017300
142GSK3B0.41694609
143DYRK20.40877112
144SGK2230.40649518
145SGK4940.40649518
146AURKB0.40546129

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.28292819
2GABAergic synapse_Homo sapiens_hsa047272.43494570
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.20935933
4Morphine addiction_Homo sapiens_hsa050322.18834012
5Circadian entrainment_Homo sapiens_hsa047132.08390454
6Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.05905283
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.97662773
8Axon guidance_Homo sapiens_hsa043601.90995474
9Synaptic vesicle cycle_Homo sapiens_hsa047211.90146738
10Dilated cardiomyopathy_Homo sapiens_hsa054141.87257090
11Basal cell carcinoma_Homo sapiens_hsa052171.86611274
12Renin secretion_Homo sapiens_hsa049241.75760625
13Non-homologous end-joining_Homo sapiens_hsa034501.69456241
14Hedgehog signaling pathway_Homo sapiens_hsa043401.64007803
15Olfactory transduction_Homo sapiens_hsa047401.60729473
16Glutamatergic synapse_Homo sapiens_hsa047241.57382254
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.56800710
18Cell cycle_Homo sapiens_hsa041101.55793752
19Steroid biosynthesis_Homo sapiens_hsa001001.54518700
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.53763119
21Oxytocin signaling pathway_Homo sapiens_hsa049211.52858604
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52755998
23Cholinergic synapse_Homo sapiens_hsa047251.46855068
24Salivary secretion_Homo sapiens_hsa049701.45163660
25Gap junction_Homo sapiens_hsa045401.45089128
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44768383
27Hippo signaling pathway_Homo sapiens_hsa043901.42925828
28Dopaminergic synapse_Homo sapiens_hsa047281.41646848
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.35238658
30Adherens junction_Homo sapiens_hsa045201.34104252
31Melanogenesis_Homo sapiens_hsa049161.33608529
32Insulin secretion_Homo sapiens_hsa049111.30634982
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.29193103
34mRNA surveillance pathway_Homo sapiens_hsa030151.28190198
35ECM-receptor interaction_Homo sapiens_hsa045121.26279965
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24349337
37Long-term potentiation_Homo sapiens_hsa047201.24053906
38Wnt signaling pathway_Homo sapiens_hsa043101.23614617
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.22357433
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22069360
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.21750806
42Mismatch repair_Homo sapiens_hsa034301.16674092
43Endometrial cancer_Homo sapiens_hsa052131.14413771
44Taste transduction_Homo sapiens_hsa047421.13835096
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12992837
46Thyroid cancer_Homo sapiens_hsa052161.12162508
47RNA transport_Homo sapiens_hsa030131.10269078
48Calcium signaling pathway_Homo sapiens_hsa040201.10012849
49Amphetamine addiction_Homo sapiens_hsa050311.08946565
50Serotonergic synapse_Homo sapiens_hsa047261.07223332
51GnRH signaling pathway_Homo sapiens_hsa049121.04193022
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03793606
53Focal adhesion_Homo sapiens_hsa045101.03082558
54Spliceosome_Homo sapiens_hsa030401.02606924
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02367170
56cAMP signaling pathway_Homo sapiens_hsa040241.02166481
57DNA replication_Homo sapiens_hsa030301.01588405
58Small cell lung cancer_Homo sapiens_hsa052221.00971961
59Gastric acid secretion_Homo sapiens_hsa049711.00833925
60Proteoglycans in cancer_Homo sapiens_hsa052051.00755219
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.99159224
62Type II diabetes mellitus_Homo sapiens_hsa049300.98786354
63Glioma_Homo sapiens_hsa052140.98557687
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96430522
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96309664
66Estrogen signaling pathway_Homo sapiens_hsa049150.94936819
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94731126
68Cardiac muscle contraction_Homo sapiens_hsa042600.92897373
69Rap1 signaling pathway_Homo sapiens_hsa040150.91818543
70Long-term depression_Homo sapiens_hsa047300.89841584
71Renal cell carcinoma_Homo sapiens_hsa052110.89414902
72Bile secretion_Homo sapiens_hsa049760.88502876
73Cocaine addiction_Homo sapiens_hsa050300.88420389
74Colorectal cancer_Homo sapiens_hsa052100.88110606
75Circadian rhythm_Homo sapiens_hsa047100.86823121
76ErbB signaling pathway_Homo sapiens_hsa040120.86777923
77mTOR signaling pathway_Homo sapiens_hsa041500.84819270
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.83647051
79Lysine degradation_Homo sapiens_hsa003100.83034695
80Prostate cancer_Homo sapiens_hsa052150.81008997
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80822714
82Melanoma_Homo sapiens_hsa052180.80469796
83Dorso-ventral axis formation_Homo sapiens_hsa043200.80087746
84Alcoholism_Homo sapiens_hsa050340.78953896
85Tight junction_Homo sapiens_hsa045300.78752261
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75337131
87TGF-beta signaling pathway_Homo sapiens_hsa043500.73104796
88Selenocompound metabolism_Homo sapiens_hsa004500.71232306
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70696325
90Amoebiasis_Homo sapiens_hsa051460.69663765
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69072266
92MicroRNAs in cancer_Homo sapiens_hsa052060.68874478
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.68254591
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67390261
95Fanconi anemia pathway_Homo sapiens_hsa034600.66667231
96Glucagon signaling pathway_Homo sapiens_hsa049220.66522215
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66446833
98MAPK signaling pathway_Homo sapiens_hsa040100.64779832
99Propanoate metabolism_Homo sapiens_hsa006400.64591989
100Arginine biosynthesis_Homo sapiens_hsa002200.64065557
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63822305
102Ras signaling pathway_Homo sapiens_hsa040140.63778736
103Biosynthesis of amino acids_Homo sapiens_hsa012300.63226217
104Pathways in cancer_Homo sapiens_hsa052000.63014709
105Notch signaling pathway_Homo sapiens_hsa043300.62581450
106Thyroid hormone synthesis_Homo sapiens_hsa049180.61328992
107Pyruvate metabolism_Homo sapiens_hsa006200.61274741
108Prion diseases_Homo sapiens_hsa050200.58453648
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58405808
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58335827
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58203525
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.58113385
113Primary bile acid biosynthesis_Homo sapiens_hsa001200.57836780
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57721612
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57213838
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55613369
117Nitrogen metabolism_Homo sapiens_hsa009100.54619985
118Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54033434
119Ovarian steroidogenesis_Homo sapiens_hsa049130.53640255
120Oocyte meiosis_Homo sapiens_hsa041140.53074013
121VEGF signaling pathway_Homo sapiens_hsa043700.53034744
122Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52866151
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52848334
124Basal transcription factors_Homo sapiens_hsa030220.52746827
125AMPK signaling pathway_Homo sapiens_hsa041520.52680892
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51867760
127Choline metabolism in cancer_Homo sapiens_hsa052310.50790962
128Insulin resistance_Homo sapiens_hsa049310.50716829
129p53 signaling pathway_Homo sapiens_hsa041150.50566692
130Insulin signaling pathway_Homo sapiens_hsa049100.48871594
131Protein digestion and absorption_Homo sapiens_hsa049740.47571906
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47316502
133Fatty acid metabolism_Homo sapiens_hsa012120.47011782
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45933434
135HIF-1 signaling pathway_Homo sapiens_hsa040660.44454154
136Chronic myeloid leukemia_Homo sapiens_hsa052200.44453299
1372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44120092
138Nucleotide excision repair_Homo sapiens_hsa034200.38671514
139Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37007137
140One carbon pool by folate_Homo sapiens_hsa006700.36338216
141Retinol metabolism_Homo sapiens_hsa008300.36219658

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